[The Significance of TLS in Patients with Gastric Cancer].

Immune checkpoint inhibitors(ICI)have significantly improved treatment outcomes for advanced gastric cancer by enhancing anti‒tumor responses through increased activity of tumor‒infiltrating CD8+ T cells. This highlights the critical role of the immune microenvironment, drawing recent attention to tumor‒associated lymphoid structures(TLS). TLS, characterized by clusters of B cells, has been associated with favorable prognoses in various cancer types. Our research has demonstrated that TLS is present in gastric cancer tissue and correlates with improved survival outcomes and better responses to ICI treatment. Furthermore, we found that TLS promotes the infiltration of CD8+ T cells and the generation of tissue‒resident memory T cells. Advancing research on TLS holds promising potential for further improving treatment outcomes in the future.