[A Case of Locally Advanced Appendiceal Cancer Successfully Resected after Treatment with mFOLFOX6 plus Bevacizumab].

Abstract

An 80-year-old woman presented with lower abdominal distension for the past 3 days. Abdominal contrast-enhanced CT revealed an irregularly shaped mass measuring 80×50 mm in the right lower abdomen, with a contrast effect. The final diagnosis was locally advanced appendiceal cancer with multiple invasions into the adjacent ileum and retroperitoneum. After 7 courses of preoperative chemotherapy with mFOLFOX6 plus bevacizumab, the tumor reduced in size, and laparoscopic ileocecal resection with D3 lymph node dissection was performed 4 months after diagnosis. Histopathological examination revealed appendiceal cancer, tub1-tub2, ypT4aN0M0, pStage ⅡB, with a histological Grade of 2 and a curative degree of A. The patient had no signs of recurrence 2 years and 6 months after surgery without receiving adjuvant chemotherapy. We reported a case of locally advanced appendiceal cancer that was successfully treated with mFOLFOX6 plus bevacizumab as preoperative chemotherapy and was curatively resected without combined resection of surrounding organs, with a discussion of the relevant literature.