Japanese Journal of Cancer and Chemotherapy最新文献_第6页

Enhanced Germinal Center Reactions Within Tertiary Lymphoid Structures Following Neoadjuvant Chemotherapy and Intestinal Care-A Path to Robust Antitumor Immune Response in Borderline Resectable Pancreatic Ductal Adenocarcinoma. 新辅助化疗和肠道护理后三级淋巴结构内的生发中心反应增强--边界可切除胰腺导管腺癌的强大抗肿瘤免疫反应之路

Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-10-01

Tetsuo Ohta, Isamu Makino, Mitsuyoshi Okazaki, Shintaro Yagi

{"title":"Enhanced Germinal Center Reactions Within Tertiary Lymphoid Structures Following Neoadjuvant Chemotherapy and Intestinal Care-A Path to Robust Antitumor Immune Response in Borderline Resectable Pancreatic Ductal Adenocarcinoma.","authors":"Tetsuo Ohta, Isamu Makino, Mitsuyoshi Okazaki, Shintaro Yagi","doi":"","DOIUrl":"","url":null,"abstract":"Background: In 2019, 4 patients with borderline resectable-pancreatic ductal adenocarcinoma(BR-PDAC)received neoadjuvant chemotherapy(NAC)with 3 cycles of gemcitabine plus nab-paclitaxel(GnP)over 12 weeks in combination with intestinal care, and subsequently underwent pancreatectomy. Surprisingly, histological response to NAC was Grade 3(viable tumor cells <10%)in 3 out of 4 patients. Aim/subjects: This study aimed to clarify the histopathological findings common to 3 patients with Grade 3 histological response to NAC.Results: Common histopathological findings were as follows: 1)each tumor bed was extensively replaced by fibrous connective tissues with a high degree of inflammatory cell infiltration, and almost no viable cancer cells were observed; 2)all cancer cells within the perineural space where perineural invasion is usually seen, had undergone cytolysis; 3)tertiary lymphoid structures(TLSs)with germinal centers were found at the periphery of each tumor bed, and many plasma cells were seen adjacent to TLSs; and 4)a lot of tingible body macrophages that phagocytosed apoptotic B cells were present around germinal center.Conclusions: NAC with 3 cycles of GnP over 12 weeks in combination with intestinal care elicited a potent antitumor immune response through enhanced germinal center reactions within TLSs.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"51 10","pages":"1038-1043"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Upper Gastrointestinal Perforation during Treatment with Regorafenib for Recurrent Rectal Cancer]. [瑞戈非尼治疗复发性直肠癌期间上消化道穿孔病例]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-10-01

Suzue Yoshizawa, Keisuke Kazama, Kazuki Otani, Itaru Hashimoto, Aya Kato, Yukio Maezawa, Sho Sawazaki, Toru Aoyama, Norio Yukawa, Aya Saito, Yasushi Rino

{"title":"[A Case of Upper Gastrointestinal Perforation during Treatment with Regorafenib for Recurrent Rectal Cancer].","authors":"Suzue Yoshizawa, Keisuke Kazama, Kazuki Otani, Itaru Hashimoto, Aya Kato, Yukio Maezawa, Sho Sawazaki, Toru Aoyama, Norio Yukawa, Aya Saito, Yasushi Rino","doi":"","DOIUrl":"","url":null,"abstract":"A 58-year-old man was treated with radical excision for rectal cancer. Pathological findings were pT3N1M0, Stage ⅢB, RAS: mutant, BRAF: mutant, MSS. The patient was followed up without adjuvant chemotherapy. Eight months after surgery, a CT scan showed recurrence of liver metastases, and chemotherapy was started. The patient was started on regorafenib as the fourth-line therapy for multiple liver metastases, distant lymph node metastases, and peritoneal dissemination. Twenty-three days after the first course, he developed severe abdominal pain and visited the emergency department on day 25. Suspecting generalized peritonitis due to perforation of the upper gastrointestinal tract, he was treated with emergency laparotomy and drainage. A perforation was found in the anterior wall of the lower gastrointestinal body and was sutured closed. There were no adverse events, and the patient was discharged on the 21st postoperative day. regorafenib is a multi-kinase inhibitor, and gastrointestinal perforation has been reported as a serious adverse event, although it is rare. We report a case of upper gastrointestinal perforation during regorafenib administration, with some discussion of the literature.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"51 10","pages":"1080-1082"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Laparoscopic Surgery for Malignant Lymphoma of the Small Intestine with Bowel Obstruction]. [腹腔镜手术治疗伴有肠梗阻的小肠恶性淋巴瘤一例]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-10-01

Naohiko Otsuka, Ouki Yasui, Wataru Iwasaki, Yujiro Kato, Teiji Takahashi

引用次数: 0

[A Case of Hepatocellular Carcinoma Relapse in the Lungs 17 Years after Liver Resection]. [肝切除术后 17 年肺部肝细胞癌复发病例]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-10-01

Ouki Yasui, Ikuo Matsuzaki, Masayo Murakami, Hiroshi Nanjo

引用次数: 0

[Ⅳ. Recent Topics of Precision Medicine for Patients with Pancreatic Cancer]. [胰腺癌患者精准医疗的最新课题]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-10-01

Shigetsugu Takano, Takanori Konishi, Tsukasa Takayashiki, Daisuke Suzuki, Nozomu Sakai, Isamu Hosokawa, Takashi Mishima, Hitoe Nishino, Kensuke Suzuki, Shinichiro Nakada, Masayuki Ohtsuka

引用次数: 0

[Early Breast Cancer Treated with Adjuvant S-1 plus Endocrine Therapy-A Report of Two Cases]. [早期乳腺癌辅助 S-1 加内分泌治疗--两个病例的报告]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-10-01

Keita Adachi, Junko Nagae, Hitomi Kubota, Shuhei Suzuki, Tomohiro Hirano, Natsuki Saigusa, Takuo Henmi, Hisao Yagishita, Hitoshi Tsuda, Kenichi Sakurai

{"title":"[Early Breast Cancer Treated with Adjuvant S-1 plus Endocrine Therapy-A Report of Two Cases].","authors":"Keita Adachi, Junko Nagae, Hitomi Kubota, Shuhei Suzuki, Tomohiro Hirano, Natsuki Saigusa, Takuo Henmi, Hisao Yagishita, Hitoshi Tsuda, Kenichi Sakurai","doi":"","DOIUrl":"","url":null,"abstract":"We report 2 cases of early breast cancer treated with adjuvant S-1 plus endocrine therapy. In case 1, a 70-year-old woman was diagnosed with right breast cancer and underwent partial mastectomy. The histopathological diagnosis was invasive ductal carcinoma(solid type), positive for estrogen receptor(ER)and progesterone receptor(PgR), negative for HER2/neu. The Ki-67 labeling index was 14%. The diameter of invasion was 27 mm, no lymph node metastasis was observed, and we confirmed the diagnosis as pT2N0M0, Stage ⅡA. A venous invasion was observed and the histological grade was Ⅱ. In case 2, a 53-year-old woman was diagnosed with left breast cancer and underwent lumpectomy. The histopathological findings showed a solid-tubular carcinoma, characterized by ER-positive, PgR-positive, HER2-negative. The Ki-67 labeling index was 24%. The tumor had an invasion of 20 mm and was diagnosed as Stage Ⅰ early-stage cancer, but there were some venous invasions and the histological grade was Ⅲ. We judged that both patients were at intermediate risk of recurrence and administered S-1 in addition to endocrine therapy. Even in cases without axillary lymph node metastasis, this combination of S-1 with endocrine therapy was considered to be a useful treatment option if the criteria of the POTENT trial were met.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"51 10","pages":"1065-1067"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Ⅰ. The Trend of Precision Medicine in Treatment of Hepatocellular Carcinoma]. [肝细胞癌治疗中的精准医学趋势]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-10-01

Junichi Arita, Shuhei Chida, Misato Horie, Naohiko Otsuka, Kimihiko Sato, Shinichiro Atsumi, Yasuhiko Nakagawa, Go Watanabe

引用次数: 0

[Cases of Malnutrition and Vitamin B1 Deficiency after Gastrointestinal Cancer Surgery]. [胃肠道癌症手术后营养不良和维生素 B1 缺乏病例]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-10-01

Junji Kawada, Minami Maruyama, Yoshitaka Okauchi, Tomonori Nomura, Yuji Ikeda, Manatsu Mizuno, Satoshi Eguchi, Yoshiki Taniguchi, Hiromitsu Hoshino, Shinya Yamashita, Hitoshi Mizuno, Yo Sasaki

{"title":"[Cases of Malnutrition and Vitamin B1 Deficiency after Gastrointestinal Cancer Surgery].","authors":"Junji Kawada, Minami Maruyama, Yoshitaka Okauchi, Tomonori Nomura, Yuji Ikeda, Manatsu Mizuno, Satoshi Eguchi, Yoshiki Taniguchi, Hiromitsu Hoshino, Shinya Yamashita, Hitoshi Mizuno, Yo Sasaki","doi":"","DOIUrl":"","url":null,"abstract":"We experienced cases of malnutrition and vitamin B1 deficiency after gastrointestinal cancer surgery, but they had a good course after vitamin B1 administration. Case 1 is a woman in her 70s who underwent laparoscopic distal gastrectomy for gastric cancer 2 months ago. While under outpatient observation, she was found collapsed at home and urgently brought to the hospital. She lost 3 kg of body weight in 2 weeks and was able to take in oral intake by giving fluids for malnutrition, but was unable to sit up unaided. During the course of hospitalization, vitamin B1 deficiency was reported, and vitamin B1 administration was started, which enabled her to walk independently. Case 2 is a man in her 50s who underwent video-assisted thoracic esophagectomy for esophageal cancer approximately 1 year ago. He was urgently brought to the hospital due to decreased oral intake due to alcohol dependence. 17.1 kg/m2 BMI, malnutrition, 67/40 mmHg blood pressure, and decreased left ventricular septal wall motion were observed. Vitamin B1 deficiency due to alcohol dependence was suspected, so vitamin B1 administration was started, and blood pressure increased within a few hours.","PeriodicalId":35588,"journal":{"name":"Japanese Journal of Cancer and Chemotherapy","volume":"51 10","pages":"1074-1076"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Introduction of Online Genetic Counseling for Hereditary Tumors Using an Online Medical Consultation Application]. [利用在线医疗咨询应用程序引入遗传性肿瘤在线遗传咨询]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-10-01

Takeshi Nakajima

引用次数: 0

[Liver, Pancreas, Biliary Tract Cancer The Recent Progress and Clinical Implications of Tumor Biomarkers in Hepatobiliary Pancreatic Malignancies]. [肝、胰、胆道癌症肝胆胰恶性肿瘤中肿瘤生物标志物的最新进展和临床意义]。

Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-10-01

Masaru Miyazaki

引用次数: 0