Fundamental Research最新文献

{"title":"Effects of early-life tactile experience enrichment on autistic-like behaviors and synaptic alterations in Shank3 mutant mice","authors":"Mingyue Liu,&nbsp;Guaiguai Ma,&nbsp;Yangming Zhang,&nbsp;Kezi Li,&nbsp;Fei Li,&nbsp;Tao Peng,&nbsp;Congcong Qin,&nbsp;Violeta G López-Huerta,&nbsp;Mario A Arias-Garcia,&nbsp;Wenting Wang,&nbsp;Dayun Feng,&nbsp;Shengxi Wu,&nbsp;Baolin Guo","doi":"10.1016/j.fmre.2025.09.011","DOIUrl":"10.1016/j.fmre.2025.09.011","url":null,"abstract":"<div><div>Autism spectrum disorder (ASD) presents a significant therapeutic challenge due to limited treatment options. While non-pharmacological approaches based on sensory stimulation have shown promise in clinical practice, the underlying mechanisms remain poorly understood. This study explored the therapeutic potential of tactile experience enrichment (TEE) during specific developmental windows in <em>Shank3</em> KO mice, a model of ASD. We found that pre-weaning TEE robustly rescued core behavioral deficits, including social interaction and repetitive grooming, whereas juvenile TEE only improved social behavior. RNA sequencing of the anterior cingulate cortex (ACC) and dorsolateral striatum (DLS) revealed TEE-induced alterations in synaptic gene expression, including the upregulation of the Polo-like kinase 1 (PLK-1) pathway, which may modulate synaptic maturation. Furthermore, pre-weaning TEE restored dendritic spine density and morphology, along with synaptic transmission, in both the ACC and DLS. These findings indicate that early tactile enrichment, particularly during the pre-weaning period, can effectively alleviate core ASD-related behaviors in <em>Shank3</em> KO mice by modulating synaptic structure and function, highlighting its potential as a therapeutic intervention for ASD.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 5","pages":"Pages 3457-3470"},"PeriodicalIF":6.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Securing China’s chromium supply through circular economy","authors":"Ziyan Gao,&nbsp;Yong Geng,&nbsp;Wenqiu Cai","doi":"10.1016/j.fmre.2025.11.010","DOIUrl":"10.1016/j.fmre.2025.11.010","url":null,"abstract":"<div><div>Ensuring a stable and sustainable supply of chromium (Cr) has become an important global issue, as many countries rely on imports to meet their demands and Cr plays a vital role in industrial production. This study aims to address such concerns by tracing the Cr flows and stocks along its life cycle in China for the period of 2020–2023 through a dynamic material flow analysis. Scenario analysis is then conducted to project future Cr supply and demand until 2050 under various circular economy strategies. Results indicate that the total Cr flows and stocks increased slightly from 2020 to 2023 due to the stable growth of stainless-steel industry. The demand for Cr is projected to peak in 2024 as both per capita in-use stock and population approach their maximum levels. Under a combined policy scenario, China’s reliance on Cr imports could decrease to 8% by 2050 if the domestic EoL recycling rate reaches the global leading level (95%) and the primary Cr resource efficiency is improved across all stages of the Cr industrial chain. Furthermore, under a technology breakthrough scenario, demand reduction and material substitution strategies could reduce import reliance to 3% by 2050. These findings highlight the critical role of circular economy strategies, including recycling, substitution, and resource efficiency improvement, in enhancing national Cr supply security. Finally, several policy recommendations are proposed to improve Cr resource efficiency.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 5","pages":"Pages 3340-3351"},"PeriodicalIF":6.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative genomic analysis reveals spine formation and coral prostaglandin tolerance in crown-of-thorns starfish","authors":"Zixuan Liu,&nbsp;Meng Qu,&nbsp;Wanghong Xiao,&nbsp;Geng Qin,&nbsp;Haiyan Yu,&nbsp;Zelin Chen,&nbsp;Shaobo Ma,&nbsp;Xin Wang,&nbsp;Longshan Lin,&nbsp;Qiang Lin","doi":"10.1016/j.fmre.2025.08.016","DOIUrl":"10.1016/j.fmre.2025.08.016","url":null,"abstract":"<div><div>Recurring outbreaks of crown-of-thorns starfish (COTS) are one of the greatest threats to corals and have caused catastrophic damage to coral reef ecosystems in recent decades. As obligate corallivores, COTS can tolerate toxic coral mucus, and the sharp spines covering their bodies provide protection from predators. While both of these characteristics are known to contribute to the vitality of COTS and aggravate the impact of COTS outbreaks, the genetic mechanisms underlying their adaptation remain unclear. In this study, we generated a chromosome-level COTS genome and suggested the importance of chromosome fusion in coral-feeding adaptation. In addition, high expression levels of EP4 receptors in the COTS spine apex indicated their potential ability to use the coral prostaglandin PGE2, which might further activate the skeletogenic gene regulatory network responsible for the growth of the spine and body plan of COTS. A comparison of the historical population sizes of COTS from different locations revealed a unique trend in the Coral Triangle, suggesting a potentially higher risk of outbreaks in this region. Our results provide a molecular basis for the adaptive evolution of COTS and a better understanding of its interactions in coral reef ecosystems.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 5","pages":"Pages 3056-3065"},"PeriodicalIF":6.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing the central dogma: Enzyme-driven gene diversification strategies for in cellulo continuous directed evolution","authors":"Liang Ma,&nbsp;Kai Chen,&nbsp;Yuan Lin,&nbsp;Yihan Deng,&nbsp;Siyu Ma,&nbsp;Yihan Lin","doi":"10.1016/j.fmre.2025.12.018","DOIUrl":"10.1016/j.fmre.2025.12.018","url":null,"abstract":"<div><div>In cellulo continuous directed evolution offers a powerful route to optimize biomolecules with enhanced or novel functions by enabling rapid, iterative exploration of vast fitness landscapes. At the heart of this approach lie intracellular gene diversification strategies, which have undergone notable innovations in recent years. Although a growing list of techniques has emerged—often tailored to distinct host organisms—they share overarching design principles rooted in the central dogma. By examining how genetic mutations are introduced and propagated through nucleic acid–processing and mutating enzymes, we gain a unifying framework for comparing and adapting these strategies. Here, we review the latest intracellular gene diversification methods within this conceptual lens, highlighting their commonalities, their mechanistic underpinnings, and their adaptability. We then discuss key opportunities for future development, aiming to guide the design of next-generation in cellulo continuous directed evolution systems with greater efficiency, broader host applicability, and finer control over mutagenesis.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 5","pages":"Pages 3008-3020"},"PeriodicalIF":6.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-brain fusion: Bidirectional empowerment between human brain and brain-inspired systems","authors":"Ziyu Li,&nbsp;Qing Li,&nbsp;Xiuxing Li,&nbsp;Zhuo Wang,&nbsp;Xia Wu","doi":"10.1016/j.fmre.2026.03.020","DOIUrl":"10.1016/j.fmre.2026.03.020","url":null,"abstract":"<div><div>Artificial intelligence (AI) is fundamentally reshaping societal futures, with its transformative applications driving profound, cross-sectoral change. From surgical robots that enhance medical precision and safety to autonomous vehicles that reconfigure transportation ecosystems, AI is accelerating social progress at an unprecedented pace and scale. Yet current AI technologies face persistent foundational challenges: overreliance on static, context-insensitive rules; limited capacity for dynamic, real-world simulation; and representation models that lack depth and integrative coherence. These limitations constrain adaptability in non-stationary environments, hinder the emergence of holistic intelligence, and obscure the mechanistic essence of true intelligence, constituting a critical barrier to artificial general intelligence (AGI). Dual-Brain Fusion, the deep, bidirectional synergy between the human brain and brain-inspired systems, represents the essential pathway to overcoming this barrier. As nature’s most sophisticated intelligent system, the human brain offers fundamental insights for brain-inspired research through its capacities for multimodal perception, adaptive cognition, and goal-directed decision-making. Although existing research has advanced perception optimization, cognitive enhancement, and decision-making improvement, it remains constrained by a single-layer simulation paradigm of brain functions, incomplete understanding of neural functional mechanisms, and the absence of engineered bidirectional interaction between the two systems. To address these challenges, this paper proposes leveraging the human brain’s perceptual, cognitive, and decision-making functional mechanisms as a unifying bridge, breaking down interdisciplinary barriers to construct a full-chain collaborative innovation paradigm centered on Dual-Brain Fusion, which enables mutual inspiration between the human brain and brain-inspired systems. Within this framework, brain-inspired systems are optimized using principles derived from human brain mechanisms, while empirical feedback from these systems informs refined analysis of brain functional mechanisms, establishing a closed loop of bidirectional empowerment. Looking ahead, the continued advancement of Dual-Brain Fusion will catalyze an intelligence leap grounded in brain functional mechanisms. This paradigm, anchored in brain mechanisms as a source of principled inspiration, drives AI breakthroughs at the level of intelligence itself, unlocks synergistic human–machine co-adaptation, and charts a developmental path toward human–machine symbiosis and co-evolution.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 5","pages":"Pages 3529-3543"},"PeriodicalIF":6.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioelectric warfare on bone infection: The role of piezoelectric biomaterials in osteomyelitis management","authors":"Yuan Zhang,&nbsp;Chenglong Chen,&nbsp;Juan Wang,&nbsp;Yuhang Xie,&nbsp;Jiaye Huang,&nbsp;Ke Wang,&nbsp;Hongru Wang,&nbsp;Shidong Wang","doi":"10.1016/j.fmre.2026.02.004","DOIUrl":"10.1016/j.fmre.2026.02.004","url":null,"abstract":"<div><div>Piezoelectric materials represent an emerging frontier in osteomyelitis therapy, offering innovative solutions to persistent challenges in bone infection treatment. These materials utilize their inherent electromechanical coupling properties to convert external stimuli, such as ultrasound and mechanical stress, into localized electrical signals. This capability facilitates targeted antibacterial effects through enhanced reactive oxygen species (ROS) generation, promotes endogenous growth factor secretion, and stimulates osteogenic differentiation—all while supporting bone regeneration. Recent advances in nano-piezoelectric systems, including hybrid organic-inorganic composites, demonstrate significant potential for addressing the complex pathophysiology of osteomyelitis, including biofilm formation, avascular necrosis, and impaired osseointegration. This review examines material classifications, antibacterial mechanisms, and regenerative applications of piezoelectric technology in bone infection management, highlighting their role in combined antibacterial-osteogenic strategies. With compelling preclinical outcomes, these materials pave the way for next-generation therapies that simultaneously eradicate infection and promote bone repair. Future research should prioritize optimizing biodegradability, enhancing piezoelectric efficiency in biological environments, and integrating these materials with conventional debridement and antibiotic therapies for clinical translation.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 5","pages":"Pages 3361-3380"},"PeriodicalIF":6.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D reconstruction of a model phytophagous mite at nano-resolution reveals a peculiar ingestion and digestion system and structural adaptation for a tiny animal","authors":"Jian-Sheng Guo,&nbsp;Dan-Ting Li,&nbsp;Guan Wang,&nbsp;Xin-Qiu Wang,&nbsp;Bernard Moussian,&nbsp;Chuan-Xi Zhang","doi":"10.1016/j.fmre.2025.10.008","DOIUrl":"10.1016/j.fmre.2025.10.008","url":null,"abstract":"<div><div>The fine structure of the globally distributed phytophagous mite, <em>Tetranychus urticae</em>, has been elucidated using serial block-face scanning electron microscopy (SBF-SEM) combined with 3D reconstruction. The reconstructed models reveal previously unknown internal adaptations tailored to its unique lifestyle. These include a specialized food ingestion structure to facilitate effective cell-sucking, a semi-closed-loop tracheal system optimized for efficient oxygen diffusion in a minute organism, and a pair of well-developed silk glands utilized for water repellency, defense and dispersion. Notably, the midgut occupies nearly the entire body cavity, housing 189 (male) and 636 (female) suspended digestive cells, except for the reproductive system. No observable connections or channels were found linking two midgut regions (ventriculus and posterior midgut), nor were valve structures or controlling muscles detected in this region in most cases, suggesting the presence of an intermittent, dynamically regulated midgut. This adaptation may address the functional demands of unique digestive cells suspended within the ventriculus. However, a funnel-shaped midgut capable of forming temporary channels for the disabled transport of digestive cells from the ventriculus to the posterior midgut was identified. These findings profoundly advance our understanding of how minute animals adapt their internal systems to specialized lifestyles.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 5","pages":"Pages 3075-3085"},"PeriodicalIF":6.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endosomes: An underappreciated player in cell signal transduction","authors":"Haoyu Wang,&nbsp;Anbing Shi","doi":"10.1016/j.fmre.2025.07.018","DOIUrl":"10.1016/j.fmre.2025.07.018","url":null,"abstract":"<div><div>Cellular signal transduction and endocytosis represent two critical biological mechanisms that facilitate the exchange of substances and information between cells and their external environment. Conventionally, it has been proposed that endocytosis primarily modulates cellular sensitivity to extracellular signaling molecules by regulating the density of receptors on the plasma membrane. However, emerging evidence highlights the multifaceted role of endosomes within the endocytic pathway, demonstrating their capacity to serve as platforms for signal formation, reception, and decoding, thereby playing a crucial role in intracellular signal transduction. As integral components of the endomembrane system, endosomes enable precise spatiotemporal localization of signaling molecules at the subcellular scale. Furthermore, their unique compositional traits provide a supportive environment for the assembly and maturation of signal transduction regulatory machinery. This review explores the essential yet often overlooked contributions of endosomes to signal transduction across four key aspects: regulating subcellular localization of signaling molecules, maintaining the efficacy of signaling molecules, and participating in signal formation and decoding processes.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 5","pages":"Pages 2999-3007"},"PeriodicalIF":6.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accurate pathologic classification of aggressive myocarditis improves insights into patient precise medicine","authors":"Xiumeng Hua,&nbsp;Jiayu Zhang,&nbsp;Han Mo,&nbsp;Xiao Chen,&nbsp;Mengni Bao,&nbsp;Zhe Sun,&nbsp;Fei Dong,&nbsp;Yijing Li,&nbsp;Shun Liu,&nbsp;Yiqi Zhao,&nbsp;Weiteng Wang,&nbsp;Zeyu Cui,&nbsp;Qian Zhao,&nbsp;Ningning Zhang,&nbsp;Jing Zhang,&nbsp;Xiyue Wang,&nbsp;Jiangping Song","doi":"10.1016/j.fmre.2025.09.008","DOIUrl":"10.1016/j.fmre.2025.09.008","url":null,"abstract":"<div><div>Because the disease's heterogeneity is ignored, the current diagnosis of myocarditis with advanced heart failure is imprecise, and there are no established criteria for subtyping this type of myocarditis. We analyzed data from 83 consecutive patients with aggressive myocarditis using a deep learning method to categorize them into three prognostically relevant phenogroups (PGs) based on myocardial whole-slide images: PG1, characterized by structural damage; PG2, dominated by autoimmune response; and PG3, driven by infections. Whole-exome sequencing of all patients revealed a significant concentration of mutations in myocardial structure-related genes in PG1, with the titin gene (<em>TTN)</em> being the most frequently mutated. In contrast, mutations in immune-related genes were more prevalent in PG2 and PG3. RNA sequencing revealed unique molecular signatures: PG1 was associated with apoptosis, fibrosis, and the activation of abnormal metabolic pathways, whereas PG2 and PG3 were linked to cell damage and the activation of divergent immune pathways. Immunohistochemical staining suggested that PG1 and PG2 were characterized by T cell infiltration while PG3 was characterized by macrophage infiltration. In addition, the interleukin-6 signal transducer (IL6ST) was identified as a novel prognostic biomarker for myocarditis. A plasma IL6ST content ≥ 332.45 ng/ml was found to be associated with poor survival from recurrence symptom (hazard ratio [HR] 22.8, 95% confidence interval [CI] 2.3 to 227.2, Log-rank <em>p</em>-value &lt; 0.0001). Finally, we used a decision tree model incorporating four clinical parameters to further validate the effectiveness of these features. This study identified three distinct PGs of aggressive myocarditis with significant differences in pathological manifestations, immunophenotyping, survival outcomes, clinical presentations, and molecular profiles. This approach improves patient selection for novel interventions and thus enables precision medicine.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 5","pages":"Pages 3431-3444"},"PeriodicalIF":6.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"H4K20me3 erasure facilitates reprogramming to totipotent-like state by promoting DUX4 mediated transcription","authors":"Danya Wu,&nbsp;Yuli Qian,&nbsp;Zhengyi Li,&nbsp;Zi Wang,&nbsp;Xinyi Zhang,&nbsp;Xiyu Cheng,&nbsp;Pengfei Xu,&nbsp;Dan Zhang,&nbsp;Hongqing Liang","doi":"10.1016/j.fmre.2025.08.004","DOIUrl":"10.1016/j.fmre.2025.08.004","url":null,"abstract":"<div><div>Epigenetic remodeling following fertilization is essential for the acquisition of embryonic totipotency. The role of H4K20me3, a key epigenetic modification, remains largely unexplored in the context of early human embryogenesis. Here, we observed a dynamic erasure of H4K20me3 modification during zygotic genome activation (ZGA), followed by a re-establishment after ZGA in human embryos. Using <em>in vitro</em> reprogramming to totipotent-like states, we demonstrated that transient removal of H4K20me3 in human embryonic stem cells promotes <em>DUX4</em>-mediated expression of totipotent genes and facilitates the transition into a totipotent-like state. Mechanistically, we show that H4K20me3 preferentially accumulates around genes specific to the 8-cell-like state, which are induced by <em>DUX4</em> and repressed by H4K20me3 modification. Furthermore, H4K20me3 enrichment near pericentromeric regions may regulate satellite repeat transcripts, which have been shown to participate in heterochromatin remodeling and totipotency reprogramming. Our findings suggest that active erasure of H4K20me3 at the human ZGA stage plays a role in facilitating the expression of totipotency genes, thereby reinforcing early human embryo development.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 5","pages":"Pages 3034-3046"},"PeriodicalIF":6.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147905450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}