Fundamental Research最新文献_第6页

Splenic extramedullary hematopoiesis in myocardial infarction 脾髓外造血在心肌梗死中的作用

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2025-09-01 DOI: 10.1016/j.fmre.2025.07.006

Nan Wang, Alan R. Tall

引用次数: 0

Primary cilia in growth plates orchestrate long bone development 生长板中的初级纤毛协调长骨发育

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2025-09-01 DOI: 10.1016/j.fmre.2025.04.014

Lei Zhang , Xiaoqiao Xu , Dike Tao , Xinyu Li , Pingping Niu , Xuyan Gong , Gongchen Li , Mengfei Yu , Yao Sun

{"title":"Primary cilia in growth plates orchestrate long bone development","authors":"Lei Zhang , Xiaoqiao Xu , Dike Tao , Xinyu Li , Pingping Niu , Xuyan Gong , Gongchen Li , Mengfei Yu , Yao Sun","doi":"10.1016/j.fmre.2025.04.014","DOIUrl":"10.1016/j.fmre.2025.04.014","url":null,"abstract":"<div><div>The growth plate plays a crucial role in long bone development and elongation, housing stem cells that contribute to bone formation. This study investigates the role of primary cilia, specialized organelles that regulate stem cell fate, in the development and repair of long bones. Here, we report the presence of primary cilia in all zones of the growth plate, particularly during embryonic development. Spatial transcriptomics and analysis of conditional knockout (CKO) mice identified that primary cilia mediate critical developmental signaling pathways within the growth plate. Disruption of primary cilia in growth plate chondroblasts or osteoblasts impaired long bone development by activating the Wnt signaling pathway and disrupting the cellular stemness. This resulted in elevated Mmp13 secretion, abnormal mineralization, and structural defects, ultimately hindering bone elongation. Time-lapse imaging showed an increased frequency of abnormal mitosis and a reduced rate of asymmetric division in skeletal stem cells (SSCs) from CKO mice. In conclusion, our findings indicated that primary cilia are critical for long bone development, regulating stem cell fate through key signaling pathways. Loss of primary cilia leads to excessive Wnt signaling and disruption of SSC stemness, impairing bone elongation. This study highlights the essential role of primary cilia in bone development and suggests potential therapeutic targets for skeletal disorders.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 5","pages":"Pages 2368-2381"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nano-oncology revisited: Insights on precise therapeutic advances and challenges in tumor 重新审视纳米肿瘤学：肿瘤精确治疗进展和挑战的见解

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2025-09-01 DOI: 10.1016/j.fmre.2025.03.024

Lesheng Teng , Ye Bi , Xiaofang Xing , Gang Yao

引用次数: 0

Metal chalcogenides as ion-exchange materials for the efficient removal of key radionuclides: A review 作为离子交换材料有效去除关键放射性核素的金属卤化物：综述

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2025-09-01 DOI: 10.1016/j.fmre.2023.10.022

Junhao Tang , Meiling Feng , Xiaoying Huang

{"title":"Metal chalcogenides as ion-exchange materials for the efficient removal of key radionuclides: A review","authors":"Junhao Tang , Meiling Feng , Xiaoying Huang","doi":"10.1016/j.fmre.2023.10.022","DOIUrl":"10.1016/j.fmre.2023.10.022","url":null,"abstract":"<div><div>The large amount of radioactive waste generated by the rapid development of nuclear energy is in urgent need of disposal. Metal chalcogenide ion-exchangers (MCIEs) are newly developed in recent years that show great potential in the field of removing radionuclides. This is a comprehensive review of the latest research progress on the removal of key radioactive ions (<em>e.g.</em>, radioactive Cs<sup>+</sup>, Sr<sup>2+</sup>, UO<sub>2</sub><sup>2+</sup>, lanthanide ions, and actinide ions) by MCIEs. The structure and ion-exchange properties of MCIEs are summarized emphatically. The ion-exchange mechanism of MCIEs is discussed and the structure-function relationship is preliminarily revealed. Easily exchangeable cations in the interlayer/channel, appropriately sized interlayer/channel/window spaces, flexible open framework, and the strong affinity of the Lewis soft base S<sup>2−</sup>/Se<sup>2−</sup> sites in the framework for soft or relatively soft metal ions, are the keys to the excellent selectivity and fast adsorption kinetics of MCIEs for radioactive ions. Finally, future research directions of metal chalcogenides for radioactive ions removal are foreseen. It is hoped that the review will provide a reference for the design of new metal chalcogenide ion-exchangers with practical application prospects for radioactive waste treatment and point to new directions for environmental radioactive contamination control.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 5","pages":"Pages 1969-1987"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139391771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Manipulation of encapsulated plasmons in solids for photonic applications 固体中封装等离子体的光子应用

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2025-09-01 DOI: 10.1016/j.fmre.2023.10.002

Rang Li , Chi Pang , Xiaoli Sun , Kambiz Jamshidi , Shengqiang Zhou , Feng Chen

引用次数: 0

Low-carbon operation technologies and challenges for process industry 过程工业低碳运行技术与挑战

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2025-09-01 DOI: 10.1016/j.fmre.2024.04.023

Chunhua Yang , Yishun Liu , Keke Huang , Dehao Wu , Weihua Gui

{"title":"Low-carbon operation technologies and challenges for process industry","authors":"Chunhua Yang , Yishun Liu , Keke Huang , Dehao Wu , Weihua Gui","doi":"10.1016/j.fmre.2024.04.023","DOIUrl":"10.1016/j.fmre.2024.04.023","url":null,"abstract":"<div><div>The process industry plays a crucial role in national economic development and national defense construction. However, as a typical energy-intensive industry, it is at the forefront of efforts to reduce carbon emissions. Information and communications technology (ICT) is an important means of achieving low-carbon operation in the process industry by strengthening the regulation of carbon flow in the production process. This paper first introduces the relevant research on low-carbon operation of industrial processes, and analyzes and summarizes the current research status and bottleneck. Then, the challenging problems faced by ICT in achieving low-carbon operation in the process industry are analyzed from four aspects: carbon emission sensing, carbon transfer modeling, carbon migration control, as well as low-carbon operation optimization throughout the entire process. Finally, the overall framework and vision for implementing low-carbon operation in the process industry through ICT are presented, and future research directions are proposed in conjunction with industrial artificial intelligence.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 5","pages":"Pages 2283-2293"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the spreading amplification effect of compound disaster rumors involving multiple public safety events 涉及多起公共安全事件的复合灾害谣言传播放大效应研究

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2025-09-01 DOI: 10.1016/j.fmre.2024.07.005

Zilin Xie , Meng Lan , Tao Xu , Yufeng Pan , Jialin Wu , Yongqiang Sun , Wenguo Weng

{"title":"Study on the spreading amplification effect of compound disaster rumors involving multiple public safety events","authors":"Zilin Xie , Meng Lan , Tao Xu , Yufeng Pan , Jialin Wu , Yongqiang Sun , Wenguo Weng","doi":"10.1016/j.fmre.2024.07.005","DOIUrl":"10.1016/j.fmre.2024.07.005","url":null,"abstract":"<div><div>A compound disaster rumor is a special type of rumor that involves multiple public safety events. Its pattern of spread is distinct from that of a general disaster rumor, which involves one public safety event. This work examines and verifies the amplification effect of the spread of compound disaster rumors (relative to general disaster rumors). A new rumor spread model based on infectious disease dynamics is proposed for compound disaster rumors involving two simultaneously occurring public safety events. The new model considers a special group of people, termed “double-hazard sensitive ignorants.” Taking this group as the initial crowd, it adds a new spread chain to existing rumor spread models. This modeling method successfully captures the amplification effect of the spread of compound disaster rumors involving two public safety events. A real case is selected for empirical analysis: the spread of a compound disaster rumor in a double-hazard scenario, consisting of an earthquake and the pandemic, in Sichuan, China in 2022. The results confirm that the spread of a pandemic-related natural disaster compound rumor has a higher peak than that of a general disaster rumor. The new model is applied in this real scenario and captures the amplification effect of the spread of compound rumors. Our study sheds light on the spreading pattern of compound disaster rumors, thereby providing guidance and assistance for future disaster rumor management.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 5","pages":"Pages 2294-2308"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to ‘Emerging terahertz sciences and technologies’ [Fundamental Research 5(2025), 514-515] “新兴太赫兹科学和技术”的勘误表[基础研究5(2025),514-515]

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2025-09-01 DOI: 10.1016/j.fmre.2025.07.011

Chao Chang , Guangwei Hu , Yiming Zhu

引用次数: 0

Loss of intraflagellar transport 140 in osteoblasts cripples bone fracture healing 成骨细胞鞭毛内转运缺失导致骨折愈合受阻

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-07-01 DOI: 10.1016/j.fmre.2022.09.006

Qiqi Fan , Xuekui Wang , Mengqi Zhou , Yubei Chen , Dike Tao , Songxi Rong , Shuang Zhou , Hui Xue , Yao Sun

{"title":"Loss of intraflagellar transport 140 in osteoblasts cripples bone fracture healing","authors":"Qiqi Fan , Xuekui Wang , Mengqi Zhou , Yubei Chen , Dike Tao , Songxi Rong , Shuang Zhou , Hui Xue , Yao Sun","doi":"10.1016/j.fmre.2022.09.006","DOIUrl":"10.1016/j.fmre.2022.09.006","url":null,"abstract":"<div><div>The indispensability of primary cilia in skeletal development has been widely recognized. We have previously shown that intraflagellar transport 140 (IFT140), a protein component of a bidirectional intraflagellar transport system required for ciliary function, controls bone development and dentinogenesis. However, it remains unknown whether IFT140 functionally contributes to bone fracture rehabilitation. Here an osteotomy-induced femoral fracture model was generated in <em>Ift140</em>-transgenic (<em>Ift140</em>-TG) and osteoblast-specific <em>Ift140</em>-conditional knockout (<em>Ift140</em>-cKO) mice. Micro-computed tomography, osteogenic induction, qualitative polymerase chain reaction, and toluidine blue and safranin O/fast green staining assays were used to characterize the dynamics of bone fracture healing from various perspectives. We found that IFT140 was relatively enriched in the bone callus and decreased in fracture-susceptible aged, or diabetic bones. <em>Ift140</em>-cKO mice had impaired osteogenic differentiation from bone mesenchymal stem cells, lower bone mass, and delayed fracture closure, whereas <em>Ift140</em>-TG mice had promising healing outcomes. Overall, our findings demonstrated for the first time that IFT140 has a beneficial role in fracture repair. Future investigation of the primary cilium in the context of aging and osteoporosis would certainly benefit patients at high risk of bone fractures.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 4","pages":"Pages 1795-1803"},"PeriodicalIF":6.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44460205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obox1 deficiency impairs fertility in female mice 缺乏Obox1会损害雌性小鼠的生育能力

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-07-01 DOI: 10.1016/j.fmre.2025.04.008

Li Wu , Jiacheng Shen , Zhenzhen Hou , Yinli Zhang , Yan Bi , Ran Zhang , Heping Bai , Wen Ye , Kang Chen , Jiang Zhu , Chenxiang Xi , Yiliang Xu , Xiaochen Kou , Yanhong Zhao , Chong Li , Hengyu Fan , Rongrong Le , Yixuan Wang , Xiaocui Xu , Shaohua Xu , Lan Kang

{"title":"Obox1 deficiency impairs fertility in female mice","authors":"Li Wu , Jiacheng Shen , Zhenzhen Hou , Yinli Zhang , Yan Bi , Ran Zhang , Heping Bai , Wen Ye , Kang Chen , Jiang Zhu , Chenxiang Xi , Yiliang Xu , Xiaochen Kou , Yanhong Zhao , Chong Li , Hengyu Fan , Rongrong Le , Yixuan Wang , Xiaocui Xu , Shaohua Xu , Lan Kang","doi":"10.1016/j.fmre.2025.04.008","DOIUrl":"10.1016/j.fmre.2025.04.008","url":null,"abstract":"<div><div>OBOX1 is a maternal factor involved in oogenesis and follicle development, yet its specific role remains unclear. Here, we demonstrated that <em>Obox1</em> knockout female mice exhibit subfertility, characterized by reduced litter size and impaired ovulation. These oocytes show minimal disruption in early embryonic development post-fertilization. However, <em>Obox1</em> deficiency leads to decreased levels of gonadotropins and female sex hormones, especially the luteinizing hormone (LH). Exogenous human chorionic gonadotropin (hCG) administration during superovulation failed to rescue the ovulation defect. Post-ovulation, the ovulation-related genes and serum progesterone levels were significantly reduced in <em>Obox1</em>-deficienct ovaries, accompanied by dysregulated steroidogenesis-related gene expression. Transcriptomic profiling of <em>Obox1</em> deficient metaphase II (MII) oocytes revealed downregulation of genes involved in mitochondrial energy metabolism and biosynthesis, and upregulation of genes associated with cell transport, transcription, RNA processing, translation. Further investigation revealed that follistatin gene expression was upregulated in both MII oocytes and ovaries of <em>Obox1</em> deficient mice, along with increased expression of <em>Gdf9, Bmp15, Foxl2</em>, and NOTCH signaling components. These findings suggest that <em>Obox1</em> is essential for maintaining hormonal balance and ovulatory function through regulating oocyte-granulosa cell interactions and steroid hormone synthesis.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 4","pages":"Pages 1570-1580"},"PeriodicalIF":6.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0