Fundamental Research最新文献_第10页

Biointerface interaction regulation based on organic semiconducting polymers 基于有机半导体聚合物的生物界面相互作用调节

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-01-01 Epub Date: 2025-10-22 DOI: 10.1016/j.fmre.2025.09.015

Xiaoning Liu , Boying Li , Liang Qiu , Dong Gao , Ran Zhang , Junjie Qi , Honggui Lv , Chengfen Xing

{"title":"Biointerface interaction regulation based on organic semiconducting polymers","authors":"Xiaoning Liu , Boying Li , Liang Qiu , Dong Gao , Ran Zhang , Junjie Qi , Honggui Lv , Chengfen Xing","doi":"10.1016/j.fmre.2025.09.015","DOIUrl":"10.1016/j.fmre.2025.09.015","url":null,"abstract":"<div><div>In complex biological systems, physical factors such as light and thermal energy affect normal physiological processes. When exposed to light stimulation, organic semiconducting polymers (OSPs) alter their physical/chemical properties through unique energy conversion capabilities, thereby regulating interfacial interactions with cells or microorganisms. In cellular interfacial interactions, ion channels act as key response elements to exogenous physical stimuli, precisely regulating physiological processes by mediating ion transmembrane transport; in microbial interfacial interactions, exogenous physical factors also significantly impact bacterial functional expression, drug resistance formation, and other aspects. In recent years, leveraging exogenous physical factors to achieve non-invasive or precise regulation of cellular/bacterial signaling pathways, molecular interactions, and metabolic processes has emerged as a frontier in physical biomedicine. Here, the latest research achievements of OSPs are summarized: under the action of external physical factors, they can regulate disease-related signaling pathways by modulating interfacial interactions with cells. Meanwhile, their regulation of microbial interfacial interactions can further affect the interactions between pathogens.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 1","pages":"Pages 560-574"},"PeriodicalIF":6.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological sequence analysis: Advances, medical applications, and challenges 生物序列分析：进展、医学应用和挑战

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-01-01 Epub Date: 2024-12-27 DOI: 10.1016/j.fmre.2024.12.007

Hang Wei , Jiangyi Shao , Bin Liu

引用次数: 0

The evolving landscape of spatial proteomics technologies in the AI age 人工智能时代空间蛋白质组学技术的发展前景

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-01-01 Epub Date: 2024-12-04 DOI: 10.1016/j.fmre.2024.11.023

Beiyu Hu , Junjie Zhu , Fangqing Zhao

{"title":"The evolving landscape of spatial proteomics technologies in the AI age","authors":"Beiyu Hu , Junjie Zhu , Fangqing Zhao","doi":"10.1016/j.fmre.2024.11.023","DOIUrl":"10.1016/j.fmre.2024.11.023","url":null,"abstract":"<div><div>Although single-cell technologies have provided deep insights into cellular heterogeneity and complexity, they fall short in explaining how cells form tissue structures, a crucial aspect for understanding the principles of complex tissues. Recently, spatial transcriptomics has begun to fill this gap, allowing in situ studies of tissues at cellular and subcellular resolution. However, these genomic-level methods primarily provide indirect measurements of cellular states, as most biological processes are controlled by proteins. Therefore, spatial proteomics has the potential to revolutionize our understanding of biological processes, with significant implications for both basic cell biology and clinical applications. In this review, we provide an overview of the recent technical achievements and remaining challenges in spatial proteomics. Specifically, we categorize the techniques into three main types: antibody-based, LC-MS/MS-based, and imaging mass spectrometry-based. We describe each method in detail and discuss its strengths and weaknesses. We also discuss the emerging opportunities of artificial intelligence for spatial proteomics. Finally, we review key issues and suggest future directions for the advancement of spatial proteomics.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 1","pages":"Pages 28-39"},"PeriodicalIF":6.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mef2d regulates mutually exclusive expression of IgZ and IgM isotypes through epigenetic modulation in a zebrafish model 在斑马鱼模型中，Mef2d 通过表观遗传调控 IgZ 和 IgM 两种异型的互斥表达

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-01-01 Epub Date: 2024-05-08 DOI: 10.1016/j.fmre.2024.04.019

Jianfei Ji , Nan Zhang , Chongbin Hu , Dongdong Fan , Xiao Huang , Aifu Lin , Ye Chen , Lixin Xiang , Jianzhong Shao

{"title":"Mef2d regulates mutually exclusive expression of IgZ and IgM isotypes through epigenetic modulation in a zebrafish model","authors":"Jianfei Ji , Nan Zhang , Chongbin Hu , Dongdong Fan , Xiao Huang , Aifu Lin , Ye Chen , Lixin Xiang , Jianzhong Shao","doi":"10.1016/j.fmre.2024.04.019","DOIUrl":"10.1016/j.fmre.2024.04.019","url":null,"abstract":"<div><div>The discovery of IgZ, or its counterpart IgT, represents a novel immunoglobulin isotype (named ζ or τ) found in teleosts, introducing a new member to the existing Ig classes (µ, δ, γ, α, and ε) among vertebrates. The distinctive intrachromosomal organization of <em>ighz</em> and <em>ighm</em> loci implies the necessity of a distinct, mutually exclusive recombination process for the independent generation of IgZ and IgM isotypes. However, the molecular mechanisms governing this process remain elusive. In this study, we unveil the regulatory function of myocyte enhancer factor 2D (Mef2d) in the assembly of <em>ighz</em> genes through epigenetic modulation in a zebrafish model. Mechanistically, Mef2d selectively hinders the recombination of <em>ighm</em> locus in IgZ<sup>+</sup> B cells by binding to the 3′Eµ site of the <em>ighm</em> locus and helping establish a repressive modification pattern of H3K4me0/H3K9me2/H3K27me2 in Dµ/Jµ regions through recruiting the co-repressive Sin3/Hdac1 complex with the assistance of cohesin complex and Setdb1/Ezh2 methyltransferases. Consequently, this renders the Dµ/Jµ regions inaccessible to Rag1/2, thus preventing <em>ighm</em> rearrangement. As a pivotal regulator for IgZ isotype production, Mef2d exhibits differential expression in committed IgZ<sup>+</sup> B cells, a process regulated by the Il-7/Il-7r-mediated p38 Mapk signaling pathway. These results indicate the existence of a unique isotypic exclusion mechanism underlying recombination between <em>ighz</em> and <em>ighm</em> locus in teleosts. This mechanism highlights an unrecognized strategy for generating diverse isotypes in vertebrates, distinct from the well-established class switch recombination process. This study significantly contributes to our understanding of paradigms, diversifications, and the evolutionary history of vertebrate adaptive immunity.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 1","pages":"Pages 246-259"},"PeriodicalIF":6.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141040434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preformer MOT: A transformer-based approach for multi-object tracking with global trajectory prediction Preformer MOT：一种基于变压器的全局轨迹预测多目标跟踪方法

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-01-01 Epub Date: 2025-01-30 DOI: 10.1016/j.fmre.2024.06.015

Yueying Wang , Yuhao Qing , Kaer Huang , Chuangyin Dang , Zhengtian Wu

{"title":"Preformer MOT: A transformer-based approach for multi-object tracking with global trajectory prediction","authors":"Yueying Wang , Yuhao Qing , Kaer Huang , Chuangyin Dang , Zhengtian Wu","doi":"10.1016/j.fmre.2024.06.015","DOIUrl":"10.1016/j.fmre.2024.06.015","url":null,"abstract":"<div><div>Multi-Object Tracking (MOT) is designed to accurately ascertain the positions and trajectories of moving objects within a video sequence. While prevalent methodologies primarily link detected objects across successive frames by leveraging appearance and motion attributes, some approaches incorporate implicit global correlations from multiple antecedent frames to delineate target trajectories. Nonetheless, the capability to predict trajectories over multiple future frames remains insufficiently explored, leading to a significant underutilization of pertinent information in MOT. To address this gap, we introduce a transformer-based methodology, termed Preformer MOT, which enhances the precision of nonlinear trajectory predictions in dynamic settings. This enhancement is achieved through an innovative combination of a novel motion estimation technique-trajectory prediction-and Kalman filtering. Our method not only utilizes historical trajectory data but also anticipates the future positions of the target objects up to n subsequent steps, thereby furnishing a comprehensive prediction of trajectories with extensive temporal correlations. Specifically, we develop a straightforward self-supervised trajectory prediction model that estimates the future positions of a target object based on previously observed positional data. During the correlation phase, if a trajectory disruption occurs due to overlapping, occlusion, or nonlinear movements of the detected objects, Preformer MOT is capable of making early predictions using data from multiple forthcoming frames to reestablish trajectory continuity. Empirical evaluations on pedestrian datasets such as DanceTrack and MOT17 demonstrate that our approach surpasses other contemporary state-of-the-art methods. Furthermore, Preformer MOT exhibits exceptional performance in complex marine environments, underscoring its adaptability and efficacy.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 1","pages":"Pages 423-431"},"PeriodicalIF":6.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rendering compact formation and trajectory tracking for cyber unmanned ground vehicles 网络无人地面车辆的紧凑编队与轨迹跟踪绘制

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-01-01 Epub Date: 2025-03-03 DOI: 10.1016/j.fmre.2023.08.018

Xiaomin Zhao , Zhengrong Cui , Chee-Meng Chew , Fangfang Dong

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Bioavailability factor for improved drinking water contaminant exposure risk assessment accuracy 提高饮用水污染物暴露风险评估准确性的生物利用度因子

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-01-01 Epub Date: 2024-11-01 DOI: 10.1016/j.fmre.2024.10.010

Yayun Zhang , Shengkun Dong , Di Zhang , Michael J. Plewa , Wenhai Chu

{"title":"Bioavailability factor for improved drinking water contaminant exposure risk assessment accuracy","authors":"Yayun Zhang , Shengkun Dong , Di Zhang , Michael J. Plewa , Wenhai Chu","doi":"10.1016/j.fmre.2024.10.010","DOIUrl":"10.1016/j.fmre.2024.10.010","url":null,"abstract":"<div><div>Despite being low in concentration, the presence of broad-spectrum chemical constituents in drinking water is a fact of modern life. The current drinking water chemical risk assessment practice predominantly relies on drinking exposure and chemical toxicity data, providing a valuable tool for regulation. However, only a fraction of chemicals is retained for a considerable duration within the human body, as the remainder are excreted or metabolized. This limits the efficacy of risk assessment when exclusively relying on water contaminants ingestion dose and toxicity potencies. We propose large scale incorporation of a bioavailability factor, <em>F</em>, into the calculation of chemical-mediated human health risk assessment for drinking water. Specifically, <em>F</em> values account for the ratio of one compound in human circulation and excretion and are multivariable specific, such as exposure route specific, and gender specific. Utilizing disinfection by-products (DBPs), an important group of chemicals commonly found in drinking water as an example, we provided detailed explanations of <em>F</em> values. Through incorporation of the <em>F</em> values, the accuracy of drinking water human health risk assessment may be improved as the biological retention ratio is accommodated, providing leniency on chemicals that less interact with the human body during internal retention. This approach has clear implications for the subsequent control measures and national drinking water standards updates for emerging pollutants.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 1","pages":"Pages 380-382"},"PeriodicalIF":6.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Enhancing non-Newtonian gravity constraint using a levitated pendulum in vacuum 利用真空中的悬浮摆加强非牛顿重力约束

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-01-01 Epub Date: 2024-01-12 DOI: 10.1016/j.fmre.2023.12.008

Fang Xiong , Leilei Guo , Pu Huang , Xiaowen Gao , Zhiming Chen , Xunmin Zhu , Tong Wu , Huizhu Hu

{"title":"Enhancing non-Newtonian gravity constraint using a levitated pendulum in vacuum","authors":"Fang Xiong , Leilei Guo , Pu Huang , Xiaowen Gao , Zhiming Chen , Xunmin Zhu , Tong Wu , Huizhu Hu","doi":"10.1016/j.fmre.2023.12.008","DOIUrl":"10.1016/j.fmre.2023.12.008","url":null,"abstract":"<div><div>The detection of non-Newtonian gravity is crucial for fundamental physics research and our understanding of dark energy. However, conducting an experiment that provides explicit evidence of its existence remains an endeavour. We propose an experiment utilizing a diamagnetically levitated pendulum in vacuum to detect non-Newtonian gravity on a micrometer scale. The pendulum configuration effectively helps to shield electromagnetic force fluctuations in the vacuum levitation system. The structural parameters of the pendulum are intentionally optimized to enhance the constraint on the non-Newtonian gravity strength <span><math><mi>α</mi></math></span>. The designed pendulum can be stably levitated in the diamagnetic trap thanks to its passive levitation mechanism. By conducting resonance force measurements at room temperature for a duration of <span><math><msup><mn>10</mn><mn>4</mn></msup></math></span> s, we anticipate a significant improvement in the constraint on the non-Newtonian gravity strength (<span><math><mrow><mi>α</mi><mo>≥</mo><mn>28</mn></mrow></math></span>) within the force range of <span><math><mrow><mi>λ</mi><mo>=</mo><mn>7.6</mn></mrow></math></span> µm. This represents an enhancement of over three orders of magnitude compared to the current limit. This study presents a promising tool for investigating short-range forces and exploring frontier physics in tabletop laboratory.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 1","pages":"Pages 141-148"},"PeriodicalIF":6.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139637731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contrasting patterns for bacteria and archaea in response to salt stress across alpine wetlands of the Tibetan Plateau 青藏高原高寒湿地的细菌和古细菌对盐胁迫的反应模式截然不同

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-01-01 Epub Date: 2024-03-07 DOI: 10.1016/j.fmre.2024.02.010

Xu Liu , Manuel Delgado-Baquerizo , Teng Yang , Gui-Feng Gao , Yu Shi , Haiyan Chu

{"title":"Contrasting patterns for bacteria and archaea in response to salt stress across alpine wetlands of the Tibetan Plateau","authors":"Xu Liu , Manuel Delgado-Baquerizo , Teng Yang , Gui-Feng Gao , Yu Shi , Haiyan Chu","doi":"10.1016/j.fmre.2024.02.010","DOIUrl":"10.1016/j.fmre.2024.02.010","url":null,"abstract":"<div><div>Understanding microbial responses to environmental stress is crucial for comprehending their distribution and supporting conservation efforts. Yet, comprehensive evaluations of these responses across diverse microbial taxa within the framework of classical ecological theories are scarce. This gap limits our ability to predict the impact of environmental changes on the diversity and functions of soil microbes in natural settings. In this study, we conducted a field survey across twenty alpine wetlands on the Tibetan Plateau. Employing amplicon sequencing with network theories, we investigated the biodiversity and coexistence of bacteria and archaea under a wide range of natural salinity conditions. Our results demonstrated a linear decrease in bacterial diversity with increased salinity, while archaeal diversity showed a non-linear pattern, initially declining and then rising, reflecting varied adaptation strategies to salt stress. Network analysis revealed a heightened complexity in positive associations among bacteria under salt stress. In contrast, archaea exhibited a decrease in both positive and negative associations, with the community succession to halophiles. These results imply that bacteria may counteract stress through enhanced facilitation, whereas archaea predominantly rely on stress-tolerant taxa. Additionally, structural equation modeling confirmed our hypothesis regarding the ecological response strategies of bacteria and archaea to salinity stress, showing that the variation in bacterial diversity is mainly explained by the complexity of positive associations, whereas archaeal diversity directly correlates with salinity levels. Overall, this study offers novel insights into the ecological strategies of prokaryotes under salinity stress and enriches our understanding of the processes maintaining microbial diversity in stressful conditions.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 1","pages":"Pages 313-323"},"PeriodicalIF":6.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140277851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Concept, development and applications of DNA computation DNA计算的概念、发展和应用

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-01-01 Epub Date: 2023-09-16 DOI: 10.1016/j.fmre.2023.06.015

Mingzhi Zhang , Da Han

引用次数: 0