Fundamental Research最新文献_第9页

Nonlinearity in optomechanical microresonators –phenomena, applications, and future 光机械微谐振器中的非线性现象、应用与未来

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-05-01 DOI: 10.1016/j.fmre.2022.12.017

Zhenning Yang , Xiaohe Tang , Jing Zhang

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SOGO-SOFI, light-modulated super-resolution optical fluctuation imaging using only 20 raw frames for high-fidelity reconstruction SOGO-SOFI，光调制超分辨率光学波动成像，仅使用20个原始帧进行高保真重建

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-05-01 DOI: 10.1016/j.fmre.2023.03.007

Fudong Xue , Wenting He , Dingming Peng , Hui You , Mingshu Zhang , Pingyong Xu

{"title":"SOGO-SOFI, light-modulated super-resolution optical fluctuation imaging using only 20 raw frames for high-fidelity reconstruction","authors":"Fudong Xue , Wenting He , Dingming Peng , Hui You , Mingshu Zhang , Pingyong Xu","doi":"10.1016/j.fmre.2023.03.007","DOIUrl":"10.1016/j.fmre.2023.03.007","url":null,"abstract":"<div><div>Taking advantage of the stochastic photoswitching of genetically encodable reversibly photoswitchable fluorescent proteins (RSFPs), super-resolution optical fluctuation imaging (SOFI) and its variant photochromic stochastic optical fluctuation imaging (pcSOFI) are valuable tools for wide field super-resolution (SR) imaging. Live-cell (pc)SOFI, which requires a small number of original frames to reconstruct an SR image, is prone to structural discontinuity artifacts and low spatial resolution. Herein, we developed a repeated synchronized on- and gradually off-switching SOFI (SOGO-SOFI) that maximized the photoswitching frequency of RSFPs by light modulation and required only 20 frames for high-quality reconstruction. Live-cell SOGO-SOFI imaging of the endoplasmic reticulum (ER) exhibited 10 times higher temporal resolution (100 fps) and fewer artifacts than pcSOFI. Moreover, a combination of SOGO-SOFI with Airyscan further increased the image contrast and the resolution of Airyscan by a factor of 1.5 from 140 nm to 91 nm. The capabilities of SOGO-SOFI were further demonstrated by dual-color imaging of nucleolar proteins in mammalian cells and deep imaging of ER structures in thick brain slices (20.6 µm).</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 3","pages":"Pages 1025-1033"},"PeriodicalIF":6.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134946023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Bioinspired multi-scale core-spun yarn-based solar evaporator for ultra-efficient and durable high-salinity brine desalination 基于生物启发的多尺度包芯纺纱太阳能蒸发器，用于超高效、耐用的高盐度盐水淡化

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-05-01 DOI: 10.1016/j.fmre.2023.09.006

Ailin Li , Mantang He , Maorong Zheng , Han Liu , Ye Liu , Huijie Liu , Jianyong Yu , Liming Wang , Xiaohong Qin

{"title":"Bioinspired multi-scale core-spun yarn-based solar evaporator for ultra-efficient and durable high-salinity brine desalination","authors":"Ailin Li , Mantang He , Maorong Zheng , Han Liu , Ye Liu , Huijie Liu , Jianyong Yu , Liming Wang , Xiaohong Qin","doi":"10.1016/j.fmre.2023.09.006","DOIUrl":"10.1016/j.fmre.2023.09.006","url":null,"abstract":"<div><div>Solar-driven interfacial desalination has been considered a promising and green technology for relieving worldwide water shortage because of its zero carbon emission. However, salt accumulation during evaporation results in a significant reduction in solar evaporation performance and sustained service life. High-performance and long-term salt-rejecting solar evaporators are urgently desirable. Inspired by the rapid water transfer driven by leaf transpiration and the capillary pressure in woody plants, we developed electrospun polyacrylonitrile @carbon nanotubes nanofiber/cotton core-spun yarn (PCCS yarn) based solar evaporator enabled by the multi-branch microchannels and sub-microchannels for ultra-efficient and durable high-salinity brine desalination. The optimal PCCS yarn-based solar evaporator exhibits a record-high evaporation rate of 3.46 kg m<sup>−2</sup>h<sup>−1</sup> under one sun illumination among 2D evaporators. Meanwhile, an excellent and stable brine desalination rate of ∼2.75 kg m<sup>−2</sup> h<sup>−1</sup> for 100 h continuous solar irradiation is achieved even in 20wt% NaCl solution. The above results are attributed to the massive micro evaporation surfaces formed between nanofibers, rapid water replenishment in the radius direction, and orientational fast water transport by Laplace pressure along and across the PCCS yarn. In addition, the continuous preparation of the core-spun yarn by the conjugated electrospinning technology and the complete fabric production process in the textile industry make it possible for the practical application of the PCCS yarn-based solar evaporator. This work promotes the development of high-performance, long-term and scalable solar desalination devices.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 3","pages":"Pages 1144-1152"},"PeriodicalIF":6.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139294506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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When Omicron knocks at door: An inverted U-shape relationship between virus proximity and prosocial behavior 当奥密克戎敲门时：病毒接近度和亲社会行为之间的倒U型关系

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-05-01 DOI: 10.1016/j.fmre.2023.07.003

Cheng Zhang , Lixian Qian , Wen Yu , Jian-Qiang Hu , Xiongwen Lu

{"title":"When Omicron knocks at door: An inverted U-shape relationship between virus proximity and prosocial behavior","authors":"Cheng Zhang , Lixian Qian , Wen Yu , Jian-Qiang Hu , Xiongwen Lu","doi":"10.1016/j.fmre.2023.07.003","DOIUrl":"10.1016/j.fmre.2023.07.003","url":null,"abstract":"<div><div>The literature suggests inconsistent evidence regarding the influence of danger on prosocial behavior. We explore this issue through a nationwide survey of 8567 households in China during the COVID-19 Omicron variant outbreak in 2022. In a zero-COVID policy, China chose to quarantine all neighborhoods with viral infections. The almost random presence of infected cases provides an opportunity to examine the relationship between the proximity of danger (i.e. potential Omicron infection) and the prosocial behavior of residents in quarantine zones. For the first time, we find an inverted U-shape relationship: residents exhibit a stronger prosocial behavior when living closer to infected cases in the neighborhood, but this positive effect diminishes when they are too close to each other. Furthermore, such non-linear relationship is salient in residents’ interpersonal helping but not in their cooperative behavior. Policymakers should be mindful of the different prosocial responses and target their efforts to help communities navigate quarantine periods more effectively.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 3","pages":"Pages 1233-1245"},"PeriodicalIF":6.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45013451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A recent survey on controllable text generation: A causal perspective 关于可控文本生成的最新调查：因果视角

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-05-01 DOI: 10.1016/j.fmre.2024.01.001

Junli Wang , Chenyang Zhang , Dongyu Zhang , Haibo Tong , Chungang Yan , Changjun Jiang

{"title":"A recent survey on controllable text generation: A causal perspective","authors":"Junli Wang , Chenyang Zhang , Dongyu Zhang , Haibo Tong , Chungang Yan , Changjun Jiang","doi":"10.1016/j.fmre.2024.01.001","DOIUrl":"10.1016/j.fmre.2024.01.001","url":null,"abstract":"<div><div>As an important subject of natural language generation, Controllable Text Generation (CTG) focuses on integrating additional constraints and controls while generating texts and has attracted a lot of attention. Existing controllable text generation approaches mainly capture the statistical association implied within training texts, but generated texts lack causality consideration. This paper intends to review recent CTG approaches from a causal perspective. Firstly, according to previous research on basic types of CTG models, it is discovered that their essence is to obtain the association, and then four kinds of challenges caused by absence of causality are introduced. Next, this paper reviews the improvements to address these challenges from four aspects, namely representation disentanglement, causal inference, knowledge enhancement and multi-aspect CTG respectively. Additionally, this paper inspects existing evaluations of CTG, especially evaluations for causality of CTG. Finally, this review discusses some future research directions for the causality improvement of CTG and makes a conclusion.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 3","pages":"Pages 1194-1203"},"PeriodicalIF":6.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139455008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Recent progress in upcycling of plastic wastes into value-added chemicals via photo-, electro- and photoelectro-catalytic strategies 通过光催化、电催化和光电催化策略将塑料废弃物转化为高附加值化学品的最新进展

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-05-01 DOI: 10.1016/j.fmre.2023.11.015

Yuanbo Liu , Haohong Duan

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Engineered bacteria: Strategies and applications in cancer immunotherapy 工程细菌：在癌症免疫治疗中的策略和应用

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-05-01 DOI: 10.1016/j.fmre.2024.11.001

Shuhao Zhang , Rui Li , Yunxue Xu , Renfa Liu , Desheng Sun , Zhifei Dai

{"title":"Engineered bacteria: Strategies and applications in cancer immunotherapy","authors":"Shuhao Zhang , Rui Li , Yunxue Xu , Renfa Liu , Desheng Sun , Zhifei Dai","doi":"10.1016/j.fmre.2024.11.001","DOIUrl":"10.1016/j.fmre.2024.11.001","url":null,"abstract":"<div><div>Cancer therapy remains a critical medical challenge. Immunotherapy is an emerging approach to regulating the immune system to fight cancer and has shown therapeutic potential. Due to their immunogenicity, bacteria have been developed as drug-delivery vehicles in cancer immunotherapy. However, ensuring the safety and efficacy of this approach poses a considerable challenge. This paper comprehensively explains the fundamental processes and synthesis principles involved in immunotherapy utilizing engineered bacteria. Initially, we list common engineered strains and discuss that growth control through genetic mutation promises therapeutic safety. By considering the characteristics of the tumor microenvironment and the interaction of specific molecules, the precision targeting of tumors can be improved. Furthermore, we present a foundational paradigm for genetic circuit construction to achieve controlled gene activation and logical expression, directly determining drug synthesis and release. Finally, we review the immunogenicity, the expression of immunomodulatory factors, the delivery of immune checkpoint inhibitors, and the utilization of bacteria as tumor vaccines to stimulate the immune system and facilitate the efficacy of cancer immunotherapy.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 3","pages":"Pages 1327-1345"},"PeriodicalIF":6.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Corrigendum to `Shear softening of earth's inner core as indicated by its high poisson ratio and elastic anisotropy' [Fundamental Research 5 (2025) 264–268] “由高泊松比和弹性各向异性表明的地球内核剪切软化”的勘误表[基础研究5 (2025)264-268]

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-05-01 DOI: 10.1016/j.fmre.2025.03.007

Zhongqing Wu , Wenzhong Wang

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Degradable polymer bone adhesives 可降解聚合物骨粘合剂

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-03-01 DOI: 10.1016/j.fmre.2023.11.023

Zijian Bao , Ran Yang , Binggang Chen , Shifang Luan

{"title":"Degradable polymer bone adhesives","authors":"Zijian Bao , Ran Yang , Binggang Chen , Shifang Luan","doi":"10.1016/j.fmre.2023.11.023","DOIUrl":"10.1016/j.fmre.2023.11.023","url":null,"abstract":"<div><div>Highly comminuted fractures and bone defects pose a significant challenge for orthopedic surgery. Current surgical procedures commonly rely on metal implants (such as bone plates, nails and pins) for fracture internal and external fixations, but they are likely to result in problems, such as stress shielding and poor bone healing. Bone adhesive represents an attractive alternative for the treatment of fracture. The ideal bone adhesive should satisfy several performance requirements, including high adhesion strength for bone tissues, rapid in-situ curing in a physiological environment, good biocompatibility with no toxicity, degradability, and good stability <em>in vivo</em>. Among these requirements, degradability is a crucial characteristic of bone adhesives. This property enables the material to be easily removed without the need for surgery at a later stage, ensuring the regeneration of bone tissue without any hindrance. The degradation rate of bone adhesive varies depending on the application scenarios and tissues, ranging from weeks to years. Many bone adhesives are unable to guarantee degradability while achieving other necessary performances. Therefore, this article provides a detailed overview of the strategies to fabricate biodegradable polymer bone adhesives that can maintain high bulk and adhesion strength, biocompatibility and other properties. Finally, the current challenges in the clinical translation of bone adhesives and their future development directions are discussed.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 2","pages":"Pages 782-795"},"PeriodicalIF":6.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140462721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Intelligent design and synthesis of energy catalytic materials 能源催化材料的智能设计与合成

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-03-01 DOI: 10.1016/j.fmre.2023.10.012

Linkai Han, Zhonghua Xiang

{"title":"Intelligent design and synthesis of energy catalytic materials","authors":"Linkai Han, Zhonghua Xiang","doi":"10.1016/j.fmre.2023.10.012","DOIUrl":"10.1016/j.fmre.2023.10.012","url":null,"abstract":"<div><div>Efficient energy conversion and storage are crucial for the sustainable development and growth of renewable energy sources. However, the limited varieties of traditional energy catalytic materials cannot match the fast-expansion requirement of raising various clean energy for industrial applications. Thus, accelerating the design and synthesis of high-performance catalysts is necessary for the application of energy equipment. Recently, with artificial intelligence (AI) technology being advanced by leaps and bounds, it is feasible to efficiently and precisely screen materials and optimize synthesis conditions in a huge unknown space. Here, we introduce and review AI techniques used in the development of catalytic materials in detail. We describe the workflow for designing and synthesizing new materials using machine learning (ML) and robotics. We summarize the sources of data collection, the intelligent algorithms commonly used to build ML models, and the laboratory modules for the intelligent synthesis of materials. We provide the illustrations of predicting the properties of catalytic materials with ML assistance in different material types. In addition, we present the potential strategies for finding material synthesis pathways, and advances in robotics to accelerate high-performance catalytic materials synthesis in the review. Finally, the summary, challenges, and potential directions in the development of AI-assisted catalytic materials are presented and discussed.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 2","pages":"Pages 624-639"},"PeriodicalIF":6.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138988734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0