Fundamental Research最新文献_第9页

Cyanido-bridged mixed-valence system: How to control the electron transfer process 氰基桥接混合离子体系：如何控制电子转移过程

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-07-01 Epub Date: 2024-03-16 DOI: 10.1016/j.fmre.2024.01.025

Yu-Ying Yang, Xiao-Lin Liu, Xin-Tao Wu, Tian-Lu Sheng

引用次数: 0

First Mesozoic entomofauna from the Qinghai-Tibetan Plateau 青藏高原第一中生代昆虫动物群

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-07-01 Epub Date: 2026-04-17 DOI: 10.1016/j.fmre.2026.04.013

Qianqi Zhang, Jun Chen, Jiahao Li, Chunpeng Xu, Zhengyu Song, Yan Fang, Daran Zheng, Edmund A. Jarzembowski, Haichun Zhang, Bo Wang

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Seizure type classification algorithm based on multi-dimensional brain network feature selection 基于多维脑网络特征选择的癫痫类型分类算法

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-07-01 Epub Date: 2025-04-21 DOI: 10.1016/j.fmre.2025.01.015

Duanpo Wu, Yixiao Mao, Yuhan Gao, Pierre-Paul Vidal, Danping Wang, Chenggang Yan

{"title":"Seizure type classification algorithm based on multi-dimensional brain network feature selection","authors":"Duanpo Wu, Yixiao Mao, Yuhan Gao, Pierre-Paul Vidal, Danping Wang, Chenggang Yan","doi":"10.1016/j.fmre.2025.01.015","DOIUrl":"10.1016/j.fmre.2025.01.015","url":null,"abstract":"<div><div>Different seizure types exhibit varying levels of redundant brain network features. In order to select features that contribute significantly to model performance, an algorithm for seizure type classification based on multi-dimensional brain network feature selection (MBNFS) is proposed. Firstly, wavelet packet transform (WPT) is applied to all channels of the electroencephalogram (EEG) signals and all the sub-band signals obtained are used as network nodes. Secondly, mutual information (MI) between different nodes is calculated to get MI matrix as edge weights. Next, we design a new brain network set construction method based on the leave-one-out method and MI matrix to formulate a set of brain networks. After that, network features are extracted through nodes and edges and further evaluated for their contributions using random forest (RF). Then, based on the leave-one-out method and a matrix where the main diagonal is 0 and the remaining elements are 1, the contributions of channels, sub-bands and network features are deduced. Leveraging these three-dimensional contributions, a multi-dimensional iterative selection is conducted, focusing on selecting the dimensional individuals whose contributions exceed the manually set threshold. Finally, the RF model is trained with the refined feature set to classify seizure types, yielding test set detection accuracy, specificity, sensitivity, F1 score and kappa values of 99.86 %, 99.86 %, 99.86 %, 0.9986 and 0.9984, respectively.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 4","pages":"Pages 2559-2570"},"PeriodicalIF":6.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Quanestimation.jl: An open-source Julia framework for quantum parameter estimation Quanestimation。一个开源的Julia框架，用于量子参数估计

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-07-01 Epub Date: 2025-03-13 DOI: 10.1016/j.fmre.2025.02.020

Huai-Ming Yu, Jing Liu

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High-resolution mapping of soil total phosphorus in China: Revealing spatiotemporal patterns and driving mechanisms 中国土壤全磷的高分辨率制图：揭示时空格局和驱动机制

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-07-01 Epub Date: 2026-04-16 DOI: 10.1016/j.fmre.2026.04.012

Zhanpeng Liu, Qiu Tan, Xiaoyong Bai

{"title":"High-resolution mapping of soil total phosphorus in China: Revealing spatiotemporal patterns and driving mechanisms","authors":"Zhanpeng Liu, Qiu Tan, Xiaoyong Bai","doi":"10.1016/j.fmre.2026.04.012","DOIUrl":"10.1016/j.fmre.2026.04.012","url":null,"abstract":"<div><div>Soil total phosphorus (STP) is a key component of the terrestrial phosphorus cycle, and its spatial distribution pattern profoundly influences ecological security and the stability of food production. This study integrates 20,372 nationwide plot monitoring records and, based on the Random Forest algorithm, constructs a 1 km resolution layered spatiotemporal map of STP across China for the period 2000–2020. The results show that China’s STP exhibits an overall “central high, northern-southern low” spatial pattern, with South China identified as a contiguous low‑phosphorus region (<0.4 g/kg). Vertically, STP decreases by approximately 25.8% with increasing soil depth. The study further reveals regional differentiation characteristics of STP variation: the mid‑temperate zone serves as the core area of phosphorus accumulation, while the middle‑lower Yangtze River region and the Sichuan Basin are identified as hotspots of phosphorus loss. Solar radiation (SR) is the main positive driver of phosphorus enrichment in plateau regions (affecting 29.1% of the national area, ca. 2.65 × 10<sup>6</sup> km²), whereas wind speed is the primary negative driver of phosphorus loss in arid regions (affecting 32.7% of the national area, ca. 2.98 × 10<sup>6</sup> km²). Temperature (Tmp) exhibits a bimodal regulatory pattern. This study systematically elucidates the integrated impacts of natural and anthropogenic factors on the spatiotemporal pattern of STP, proposes a multi‑scale analytical framework for soil phosphorus cycling, and provides both data support and scientific basis for the zonal management of phosphorus resources and sustainable agricultural development.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 4","pages":"Pages 2427-2437"},"PeriodicalIF":6.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct factors drive the progression of tau pathology in Alzheimer’s disease 不同的因素驱动阿尔茨海默病中tau病理的进展

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-07-01 Epub Date: 2025-04-09 DOI: 10.1016/j.fmre.2025.04.001

Yifan Luo, Honglu Yu, Keqiang Ye

{"title":"Distinct factors drive the progression of tau pathology in Alzheimer’s disease","authors":"Yifan Luo, Honglu Yu, Keqiang Ye","doi":"10.1016/j.fmre.2025.04.001","DOIUrl":"10.1016/j.fmre.2025.04.001","url":null,"abstract":"<div><div>Alzheimer’s disease (AD) is the most common cause of dementia worldwide. The primary histopathological markers for AD diagnosis are extracellular amyloid plaques and intracellular neurofibrillary tangles (NFTs), featured by aggregation of hyperphosphorylated and truncated tau proteins. Emerging evidence shows that tau pathology, rather than amyloid-β deposition, exhibits a stronger correlation with brain atrophy and cognitive decline in AD, emphasizing its pivotal role in disease progression. However, the molecular mechanisms of tau propagation in the brain are incompletely understood, and there is no effective therapy to halt tau pathology propagation in AD. In this review, we summarize current knowledge on the multifactorial triggers of tau pathology in AD in the aspects of (1) physiological or pathological driving factors, (2) different types of brain cells and (3) key regulatory proteins that steer tau aggregation and spread. Based on these findings, we also critically evaluate the current and potential therapeutic strategies against tau pathology in AD. Together, this review provides a comprehensive understanding of tau pathology regulation and highlights promising strategies for therapeutic intervention.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 4","pages":"Pages 2289-2298"},"PeriodicalIF":6.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonreciprocal quantum optics: New effects and applications in quantum sensing 非互易量子光学：在量子传感中的新效应和应用

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-07-01 Epub Date: 2025-01-06 DOI: 10.1016/j.fmre.2024.12.018

Ya-Feng Jiao, Jie Wang, Qian Zhang, Hui-zu Lin, Hui Jing

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p53 mutation-associated prognosis across cancer types underlines hematological malignancy as an applicable cancer type to p53-rescue therapy 不同癌症类型的P53突变相关预后强调了血液恶性肿瘤是一种适用于P53拯救治疗的癌症类型

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-07-01 Epub Date: 2025-06-30 DOI: 10.1016/j.fmre.2025.06.011

Shujun Xiao, Jiaqi Wu, Kai Tan, Sujiang Zhang, Yuting Dai, Jiarui Wu, Jiale Wu, Xinle Han, Derun Zheng, Xin Wang, Huaxin Song, Min Lu

{"title":"p53 mutation-associated prognosis across cancer types underlines hematological malignancy as an applicable cancer type to p53-rescue therapy","authors":"Shujun Xiao, Jiaqi Wu, Kai Tan, Sujiang Zhang, Yuting Dai, Jiarui Wu, Jiale Wu, Xinle Han, Derun Zheng, Xin Wang, Huaxin Song, Min Lu","doi":"10.1016/j.fmre.2025.06.011","DOIUrl":"10.1016/j.fmre.2025.06.011","url":null,"abstract":"<div><div>Tumor suppressor p53 is mutated and thereafter loses tumor-suppressive function in about 50% of cancer cases, across nearly all cancer types. Efforts to rescue mutant p53 pharmacologically have been ongoing for decades, leading to reports of approximately 71 mutant p53-rescue small-molecule compounds and > 20 clinical trials. However, no statistically significant patient benefit has been achieved, possibly due to the lack of rationalization of cancer type selection in the trials. Here, we analyzed p53 mutation-associated prognosis of overall survival, together with tumor mutation burden and concurrent cancer driver mutation with p53 mutation, across 33 cancer types in The Cancer Genome Atlas (TCGA), through which hematology malignancy was predicted as a cancer type potentially responding to p53-rescue therapy. In validation experiments, p53-null hematological malignant cell lines exhibited high sensitivity to the introduction of exogenous wild-type p53 as compared to solid-tumor cell lines. Furthermore, hematological malignant cell lines harboring structural mutant p53 are also more sensitive to the established mutant p53 rescue compound arsenic trioxide (ATO). In p53-mutant hematological malignant cells, the majority of the beneficial p53-regulating genes are upregulated while the majority of the deleterious p53-regulating genes are downregulated by ATO treatment, predicting a beneficial outcome of ATO in treating hematological malignancies in the clinic. Together, we propose a guideline for the rational selection of cancer types in the rapidly expanding p53-rescue clinical trials.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 4","pages":"Pages 2711-2724"},"PeriodicalIF":6.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Synchronized in-gap edge states and robust copropagation in topological insulators without magnetic flux 无磁通拓扑绝缘体的同步隙内边缘态和鲁棒共传播

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-07-01 Epub Date: 2025-01-21 DOI: 10.1016/j.fmre.2025.01.005

Liangcai Xie, Tianyi He, Liang Jin

{"title":"Synchronized in-gap edge states and robust copropagation in topological insulators without magnetic flux","authors":"Liangcai Xie, Tianyi He, Liang Jin","doi":"10.1016/j.fmre.2025.01.005","DOIUrl":"10.1016/j.fmre.2025.01.005","url":null,"abstract":"<div><div>Copropagation of antichiral edge states in the metallic phase requires the bulk states as counterpropagating modes. Without the band gap protection, the copropagation along the boundaries is easily scattered into the bulk and the counterpropagation in the bulk is not robust against disorder and defects. Here, we propose a novel time-reversal symmetric topological insulator holding the synchronized in-gap edge states. To prevent the participation of bulk states, we introduce the time-reversal symmetry to detach the edge states from the bulk band, then the robust copropagation is realized through widening the band gap across a metal-insulator transition with anisotropic next-nearest-neighbor couplings. The time-reversal symmetry ensures the in-gap edge states with opposite momenta as the counterpropagating modes. The inversion symmetry protects the quantized polarization as a topological invariant. The synchronized in-gap edge states not only enrich the family of topological edge states, but also provide additional flexibility in the design of reconfigurable topological optical devices. Our findings open a new avenue for the tailored robust wave transport using the in-gap edge states for future acousto-optic topological metamaterials.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 4","pages":"Pages 2153-2159"},"PeriodicalIF":6.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New horizon of in-situ Raman spectroelectrochemistry on single crystal surfaces 单晶表面原位拉曼光谱电化学新视野

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-07-01 Epub Date: 2024-04-10 DOI: 10.1016/j.fmre.2024.03.024

Qiong-Qiong Li, Shu-Min Li, Yao-Hui Wang, Jian-Feng Li

引用次数: 0