Fundamental Research最新文献_第8页

The development of ultrasensitive microcalorimeters for bioanalysis and energy balance monitoring 用于生物分析和能量平衡监测的超灵敏微量热计的研制

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2024-11-01 DOI: 10.1016/j.fmre.2023.01.011

Hanliang Zhu , Lan Wang , Jianguo Feng , Pavel Neuzil

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Methane mitigation potentials and related costs of China's coal mines 中国煤矿的甲烷减排潜力及相关成本

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2024-11-01 DOI: 10.1016/j.fmre.2023.09.012

Yating Kang , Peipei Tian , Jiashuo Li , Hetong Wang , Kuishuang Feng

{"title":"Methane mitigation potentials and related costs of China's coal mines","authors":"Yating Kang , Peipei Tian , Jiashuo Li , Hetong Wang , Kuishuang Feng","doi":"10.1016/j.fmre.2023.09.012","DOIUrl":"10.1016/j.fmre.2023.09.012","url":null,"abstract":"<div><div>Mitigating methane (CH4) emissions from China's coal mines as the largest contributor to anthropogenic CH4 emissions is vital for limiting global warming. However, the knowledge about CH4 mitigation potentials and economic costs of Chinese coal mines remain poorly understood, which hinders the formulation of tailored CH4 mitigation strategies. Here, we estimate and project China's provincial coal mine methane (CMM) emissions, mitigation potentials and costs under various coal production scenarios, by integrating the dynamic emission factors of CMM and key abatement technologies. We find that through continuous coal cuts and available CMM mitigation measures, China's CMM emissions can be reduced by 65%-78% (10.9 Tg-13.1 Tg) in 2060, compared with the 2021 level. CH4 emissions from abandoned coal mines will far exceed those from coal mining under the 2060 carbon-neutral scenario, especially in northeastern China. It was also found that CMM mitigation is not economically feasible at present, but may be the most cost-effective solution as CO2 prices increase. All coal-producing provinces can achieve CMM mitigation below 50 RMB/t CO2e in 2060. Inner Mongolia is identified as a hotspot for CMM mitigation with huge potential and lower cost. Our prospective assessment can provide insights into China's CMM mitigation in response to climate change.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"4 6","pages":"Pages 1688-1695"},"PeriodicalIF":6.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Redox-manipulated RhOx nanoclusters uniformly anchored on Sr2Fe1.45Rh0.05Mo0.5O6–δ perovskite for CO2 electrolysis 氧化还原操纵的RhOx纳米团簇均匀锚定在Sr2Fe1.45Rh0.05Mo0.5O6 -δ钙钛矿上进行CO2电解

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2024-11-01 DOI: 10.1016/j.fmre.2022.07.010

Houfu Lv , Le Lin , Xiaomin Zhang , Yuefeng Song , Rongtan Li , Jingwei Li , Hiroaki Matsumoto , Na Ta , Chaobin Zeng , Huimin Gong , Qiang Fu , Guoxiong Wang , Xinhe Bao

{"title":"Redox-manipulated RhOx nanoclusters uniformly anchored on Sr2Fe1.45Rh0.05Mo0.5O6–δ perovskite for CO2 electrolysis","authors":"Houfu Lv , Le Lin , Xiaomin Zhang , Yuefeng Song , Rongtan Li , Jingwei Li , Hiroaki Matsumoto , Na Ta , Chaobin Zeng , Huimin Gong , Qiang Fu , Guoxiong Wang , Xinhe Bao","doi":"10.1016/j.fmre.2022.07.010","DOIUrl":"10.1016/j.fmre.2022.07.010","url":null,"abstract":"<div><div>The sluggish reaction kinetics of CO2 electroreduction in perovskite-based cathodes severely limits the efficiency of solid oxide electrolysis cells (SOECs). The construction of the high-density active sites on the perovskite surface is crucial for promoting CO2 electrolysis in SOEC. In this study, we explore a redox-induced redispersion strategy to produce RhOx nanoclusters uniformly anchored on a Sr2Fe1.45Rh0.05Mo0.5O6–δ (SFRhM) perovskite surface with a high density of 36,000 µm−2. Compared with non-uniformly distributed RhOx nanoparticles on Sr2Fe1.5Mo0.5O6–δ (RhOx/SFM) prepared by a conventional impregnation process, the successive reduction and oxidation treatment first exsolves the highly dispersed RhFe alloy nanoparticles on SFRhM and then selectively dissolves the iron species in the RhFe alloy nanoparticles into the bulk of SFRhM, resulting in fully exposed RhOx nanoclusters uniformly anchored on the SFRhM surface (RhOx@SFRhM). Electrochemical measurements and density functional theory calculations indicate that the high-density RhOx@SFRhM interfaces promote CO2 adsorption and activation during CO2 electrolysis, thus leading to improved electrocatalytic activity and stability compared to that of its SFRhM and RhOx/SFM counterparts.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"4 6","pages":"Pages 1515-1522"},"PeriodicalIF":6.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42427847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Macrophage migration inhibitory factor (MIF) in CNS diseases: Functional regulation and potential therapeutic indication 巨噬细胞迁移抑制因子（MIF）在中枢神经系统疾病中的功能调控及潜在的治疗指征

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2024-11-01 DOI: 10.1016/j.fmre.2023.05.008

Yu Zhang , Zhexiang Yu , Na Ye , Xuechu Zhen

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Towards sustainable use of acidic soils: Deciphering aluminum-resistant mechanisms in plants 迈向酸性土壤的可持续利用:解读植物的抗铝机制

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2024-11-01 DOI: 10.1016/j.fmre.2023.03.004

Xiao Fang Zhu , Ren Fang Shen

{"title":"Towards sustainable use of acidic soils: Deciphering aluminum-resistant mechanisms in plants","authors":"Xiao Fang Zhu , Ren Fang Shen","doi":"10.1016/j.fmre.2023.03.004","DOIUrl":"10.1016/j.fmre.2023.03.004","url":null,"abstract":"<div><div>The widespread occurrence of acidic soils presents a major challenge for agriculture, as it hampers productivity via a combination of mineral toxicity, nutrient deficiency, and poor water uptake. Conventional remediation methods, such as amending the soil with lime, magnesium, or calcium, are expensive and not environmentally friendly. The most effective method to mitigate soil acidity is the cultivation of acid-tolerant cultivars. The ability of plants to tolerate acidic soils varies significantly, and a key factor influencing this tolerance is aluminum (Al) toxicity. Therefore, understanding the physiological, molecular, and genetic underpinnings of Al tolerance is essential for the successful breeding of acid-tolerant crops. Different tolerance mechanisms are regulated by various genes and quantitative trait loci in various plant species, and molecular markers have been developed to facilitate gene cloning and to support marker-assisted selection for breeding Al-tolerant cultivars. This study provides a comprehensive review of the current developments in understanding the physiological and molecular mechanisms underlying Al resistance. Through the application of genome-wide association methods, it is expected that new Al-resistant genes can be identified and utilized to cultivate Al-resistant varieties through intercrossing, backcrossing, and molecular marker-assisted selection, promoting the sustainable use of acidic soils.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"4 6","pages":"Pages 1533-1541"},"PeriodicalIF":6.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45508598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The role of pentacoordinate Al3+ sites of Pt/Al2O3 catalysts in propane dehydrogenation Pt/Al2O3催化剂五配位Al3+在丙烷脱氢中的作用

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2024-11-01 DOI: 10.1016/j.fmre.2022.08.020

Yan Wang , Chunlei Pei , Xianhui Wang , Guodong Sun , Zhi-Jian Zhao , Jinlong Gong

{"title":"The role of pentacoordinate Al3+ sites of Pt/Al2O3 catalysts in propane dehydrogenation","authors":"Yan Wang , Chunlei Pei , Xianhui Wang , Guodong Sun , Zhi-Jian Zhao , Jinlong Gong","doi":"10.1016/j.fmre.2022.08.020","DOIUrl":"10.1016/j.fmre.2022.08.020","url":null,"abstract":"<div><div>Pentacoordinate Al3+ (Al3+penta) sites on alumina (Al2O3) could anchor and stabilize the active site over the catalyst surface. The paper describes the specific effect of Al3+penta sites on the structure and the catalytic performance of Al2O3 supported Pt catalysts by modulating the quantity of Al3+penta sites. The Al3+penta site content of Al2O3 exhibits a volcano-type profile as a function of calcination temperature due to the structural rearrangement. The loading of Pt and subsequent calcination can consume a significant portion of Al3+penta sites over the Al2O3 support. We further find that, when the calcination temperature of the impregnated Al2O3 is higher than the calcination temperature of Al2O3 precursor, the structural rearrangement of Al3+penta sites could make Pt partially buried in Al2O3. Consequently, this partially buried structure leads to relatively low conversion but high stability for propane dehydrogenation. This work further elucidates the stabilization mechanism of the Al3+penta site over Al2O3 support.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"4 6","pages":"Pages 1480-1487"},"PeriodicalIF":6.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47988012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges and prospects for advanced packaging 先进包装的挑战和前景

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2024-11-01 DOI: 10.1016/j.fmre.2023.04.014

Zhiwen Chen , Jiaju Zhang , Shizhao Wang , Ching-Ping Wong

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Integrated chips: An interdisciplinary evolution in the Post-Moore Era 集成芯片：后摩尔时代的跨学科进化

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2024-11-01 DOI: 10.1016/j.fmre.2024.09.009

Ninghui Sun , Ming Liu

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Spatiotemporal information conversion machine for time-series forecasting 时序预测的时空信息转换机

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2024-11-01 DOI: 10.1016/j.fmre.2022.12.009

Hao Peng , Pei Chen , Rui Liu , Luonan Chen

{"title":"Spatiotemporal information conversion machine for time-series forecasting","authors":"Hao Peng , Pei Chen , Rui Liu , Luonan Chen","doi":"10.1016/j.fmre.2022.12.009","DOIUrl":"10.1016/j.fmre.2022.12.009","url":null,"abstract":"<div><div>Making time-series forecasting in a robust way is a difficult task only based on the observed data of a nonlinear system. In this work, a neural network computing framework, the spatiotemporal information conversion machine (STICM), was developed to efficiently and accurately render a forecasting of a time series by employing a spatial-temporal information (STI) transformation. STICM combines the advantages of both the STI equation and the temporal convolutional network, which maps the high-dimensional/spatial data to the future temporal values of a target variable, thus naturally providing the forecasting of the target variable. From the observed variables, the STICM also infers the causal factors of the target variable in the sense of Granger causality, which are in turn selected as effective spatial information to improve the robustness of time-series forecasting. The STICM was successfully applied to both benchmark systems and real-world datasets, all of which show superior and robust performance in time-series forecasting, even when the data were perturbed by noise. From both theoretical and computational viewpoints, the STICM has great potential in practical applications in artificial intelligence or as a model-free method based only on the observed data, and also opens a new way to explore the observed high-dimensional data in a dynamical manner for machine learning.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"4 6","pages":"Pages 1674-1687"},"PeriodicalIF":6.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43960657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Biodegradable nanoparticles-mediated targeted drug delivery achieves trans-spatial immunotherapy 可生物降解纳米颗粒介导的靶向药物递送实现跨空间免疫治疗

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2024-11-01 DOI: 10.1016/j.fmre.2022.11.003

Yi Wang , Min Qian , Yibo Xie , Xiaoyi Zhang , Yanhui Qin , Rongqin Huang

{"title":"Biodegradable nanoparticles-mediated targeted drug delivery achieves trans-spatial immunotherapy","authors":"Yi Wang , Min Qian , Yibo Xie , Xiaoyi Zhang , Yanhui Qin , Rongqin Huang","doi":"10.1016/j.fmre.2022.11.003","DOIUrl":"10.1016/j.fmre.2022.11.003","url":null,"abstract":"<div><div>Immunotherapy has been seriously retarded due to inadequate antigen presentation and a tumor cell-dominated immunosuppressive microenvironment (TME). Herein, biodegradable multifunctional mesoporous silica nanoparticles, with dispersed carbon nanodots incorporated into the frameworks, active TKD peptide modification on the surfaces and hydrophobic drug loading in the pores, were prepared for targeted chemotherapy synergized with trans-spatial immunotherapy. The nanoparticles were biodegradable due to nanodot-induced framework swelling, which would (1) kill the in situ tumor cells and promote antigen release by targeted chemotherapy and (2) trigger biodegraded debris involving TKD and CDs to largely adsorb the tumor antigens via π-π conjugation synergized hydrophobic interactions and then massively transport these antigens from the tumor cell-dominated TME to the immune cell-dominated spleen via TKD-mediated small size effects. Thereafter, these antigens can be processed into antigen peptides via TKD-mediated lysosome endocytosis and then activate T cells in the spleen via MHC complex construction and dendritic cell cytomembrane presentation. Therefore, improved immunotherapy with trans-spatial antigen presentation avoided TME immunosuppression, which when synergized with targeted chemotherapy, markedly enhanced the therapeutic outcomes of triple-negative breast cancer.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"4 6","pages":"Pages 1639-1649"},"PeriodicalIF":6.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47468673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0