Fundamental Research最新文献

Intratumoral microorganisms and artificial antitumor bacteria 肿瘤内微生物和人工抗肿瘤细菌

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2025-09-01 DOI: 10.1016/j.fmre.2023.06.002

Wenna Li , Xiaotu Ma , Xiao Zhao

引用次数: 0

Spatial and seasonal dynamics of biogenic silica in a eutrophic marginal sea, the East China Sea 东海富营养化边缘海生物成因二氧化硅的空间和季节动态

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2025-09-01 DOI: 10.1016/j.fmre.2023.07.005

Yating Li , Xinyuan Zhang , Danna Wang , Xin Liu , Kuanbo Zhou , Bangqin Huang , Minhan Dai , Zhimian Cao

{"title":"Spatial and seasonal dynamics of biogenic silica in a eutrophic marginal sea, the East China Sea","authors":"Yating Li , Xinyuan Zhang , Danna Wang , Xin Liu , Kuanbo Zhou , Bangqin Huang , Minhan Dai , Zhimian Cao","doi":"10.1016/j.fmre.2023.07.005","DOIUrl":"10.1016/j.fmre.2023.07.005","url":null,"abstract":"<div><div>Biogenic silica (BSi) is a key component of the marine silicon cycle, which is mainly driven by diatom metabolism notably contributing to primary production and export of particulate organic carbon (POC), particularly in ocean margins. Based on a large data set collected in the East China Sea (ECS), including BSi, fucoxanthin (Fuco), POC, and total suspended matter (TSM), we systematically explored the distribution and control of BSi in a typical eutrophic marginal sea. Spatially, BSi concentrations generally decreased from the shelf to the slope during all seasons, because the former is largely fed by river plumes and/or coastal currents enriched in nutrients favoring diatom growth. Abundant BSi was also observed in nearshore bottom waters probably influenced by sediment resuspension indicated by high TSM concentrations. Seasonally, BSi concentrations were on average higher in summer and autumn than in spring and winter, which reflects elevated diatom productivity during warm seasons. The BSi standing stock in the shallow water column of the ECS was significantly correlated with that of Fuco demonstrating diatoms’ dominant control on BSi dynamics. In addition, significant relationships between BSi and POC standing stocks were observed in summer and autumn, indicating the major role of diatoms in C fixation. By comparing with the northern South China Sea (NSCS), we suggested relatively small seasonal variability of BSi on the ECS shelf but significant decrease during cold seasons in the ECS slope. In the latter case, diatoms are ecologically and biogeochemically more important and more sensitive to the changing physical and/or chemical conditions than in the oligotrophic NSCS slope.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 5","pages":"Pages 2097-2110"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135387804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Symmetries and integrable systems 对称性和可积分系统

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2025-09-01 DOI: 10.1016/j.fmre.2023.11.008

Sen-Yue Lou , Bao-Feng Feng

{"title":"Symmetries and integrable systems","authors":"Sen-Yue Lou , Bao-Feng Feng","doi":"10.1016/j.fmre.2023.11.008","DOIUrl":"10.1016/j.fmre.2023.11.008","url":null,"abstract":"<div><div>Symmetry plays key roles in modern physics especially in the study of integrable systems because of the existence of infinitely many local and nonlocal generalized symmetries. In addition to the fundamental role to find exact group invariant solutions via Lie point symmetries, some important new developments on symmetries and conservation laws are reviewed. The recursion operator method is important to find infinitely many local and nonlocal symmetries of (1 + 1)-dimensional integrable systems. In this paper, it is pointed out that a recursion operator may be obtained from one key symmetry, say, a residual symmetry. For (2 + 1)-dimensional integrable systems, the master-symmetry approach and the formal series symmetry method are reviewed. For the discrete systems, the symmetry related discrete KP hierarchy and the BKP hierarchy are also discussed. One believes that all the solutions of integrable models may be obtained by means of symmetry approach because the Darboux transformations and algebro-geometric solutions can be obtained from the localization of nonlocal symmetries and the symmetry constraint approach. The conservation laws are used to find higher dimensional integrable system from lower dimensional ones via a deformation algorithm. The ren variable, an extension of the Grassmann variable, are introduced to find novel aspect on integrable theory. The super-integrable theory and super-symmetric integrable theory are extended to ren integrable and ren-symmetric integrable theories.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 5","pages":"Pages 1947-1953"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138617525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive understanding of fluorination-performance relationship: The best-performed A-D-A-type acceptors 全面理解氟化性能关系：性能最佳的A-D-A型受体

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2025-09-01 DOI: 10.1016/j.fmre.2023.03.010

Yuanyuan Jiang , Wenli Su , Wenxuan Wang , Feng Liu , Wuyue Liu , Shengjie Xu , Wenkai Zhang , Jianhui Hou , Xiaozhang Zhu

{"title":"Comprehensive understanding of fluorination-performance relationship: The best-performed A-D-A-type acceptors","authors":"Yuanyuan Jiang , Wenli Su , Wenxuan Wang , Feng Liu , Wuyue Liu , Shengjie Xu , Wenkai Zhang , Jianhui Hou , Xiaozhang Zhu","doi":"10.1016/j.fmre.2023.03.010","DOIUrl":"10.1016/j.fmre.2023.03.010","url":null,"abstract":"<div><div>Acceptor-donor-acceptor (A-D-A)-type nonfullerene acceptors (NFAs) have contributed to an efficiency breakthrough in organic solar cells (OSCs). However, the absence of an in-depth understanding of how to achieve high charge generation probability while guaranteeing low energy loss by molecular design has caused the stagnation of power conversion efficiency (PCE) in A-D-A-type acceptors. The fluorination strategy, as an effective approach to regulating molecular photoelectric and aggregation properties, can significantly affect device performance in OSCs. However, a comprehensive understanding of the relationship between fluorination and photovoltaic performance has been scarcely investigated thus far. Herein, a series of A-D-A-type acceptors, named ZITI-N-nF (<em>n</em> = 2, 4, 6, 8, representing the number of fluorine atoms), were designed and synthesized to reveal the underlying work mechanism of OSCs with low energy loss and efficient charge generation via fine-tuning of the charge-transfer state. The results indicate that ZITI-N-6F-based devices exhibit impressive charge generation probability with low energy loss (<em>E</em><sub>loss</sub>) because of the reduced nonradiative recombination, thus leading to a high PCE of 16.11% in binary OSCs and a PCE of 17.09% in ternary OSCs. Notably, a PCE of 16.6% was verified by the National Institute of Metrology, China, which is the highest certified PCE among OSCs based on A-D-A-type NFAs.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 5","pages":"Pages 2008-2017"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43490225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nano-synthetic biology for disease diagnosis and treatment 用于疾病诊断和治疗的纳米合成生物学

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2025-09-01 DOI: 10.1016/j.fmre.2025.07.002

Feng Li , Lizeng Gao , Fang Yang , Ning Gu , Xiyun Yan , Xian-En Zhang

引用次数: 0

Psychedelics for anxiety disorders: Challenges and opportunities 致幻剂治疗焦虑症：挑战与机遇

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2025-09-01 DOI: 10.1016/j.fmre.2025.07.008

Chenshu Gao, Heming Cheng

引用次数: 0

Supramolecular macrocyclic artificial ion channels for biomedical applications 生物医学应用的超分子大环人工离子通道

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2025-09-01 DOI: 10.1016/j.fmre.2024.06.012

Yamin Liu , Dao Shi , Bowen Li , Yimin Jin , Daishun Ling , Fangyuan Li

{"title":"Supramolecular macrocyclic artificial ion channels for biomedical applications","authors":"Yamin Liu , Dao Shi , Bowen Li , Yimin Jin , Daishun Ling , Fangyuan Li","doi":"10.1016/j.fmre.2024.06.012","DOIUrl":"10.1016/j.fmre.2024.06.012","url":null,"abstract":"<div><div>Biological ion channels are essential for ion and molecule transport, playing a critical role in maintaining cellular equilibrium and regulating vital physiological functions such as cell growth, hormone secretion, and nerve-muscle interactions. Drawing inspiration from nature, researchers have crafted an array of supramolecular artificial ion channels (AICs) using both unimolecular and self-assembly approaches. Notably, AICs based on macrocyclic molecules, such as cyclodextrins, crown ethers, and pillararenes, offer distinct advantages, including biocompatibility, precise structural design, ease of customization, and simple preparation. This review spotlights recent progress in bioinspired AICs rooted in macrocycles and their applications in the realm of biomedicine. We commence with an overview of the significance of biological channels and the strategies employed for fashioning supramolecular artificial channels. Subsequently, we navigate through the intricate landscape of molecular design, structural modulation, and the ion transport prowess exhibited by macrocycle-based AICs. Furthermore, we explore the promising biomedical applications of these AICs, encompassing roles in antibacterial measures, anticancer interventions, biosensing technologies, and treatments for channelopathies. Finally, we address the persisting challenges and illuminate prospects within this field, with the ultimate aim of steering future innovations in the development of supramolecular AICs.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 5","pages":"Pages 1860-1875"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interface engineering of Z-scheme heterojunction for photocatalytic water splitting 用于光催化水分离的 Z 型异质结的界面工程设计

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2025-09-01 DOI: 10.1016/j.fmre.2024.05.017

Daming Zhao , Yuxiao Yang , Vasileios Binas , Shaohua Shen

{"title":"Interface engineering of Z-scheme heterojunction for photocatalytic water splitting","authors":"Daming Zhao , Yuxiao Yang , Vasileios Binas , Shaohua Shen","doi":"10.1016/j.fmre.2024.05.017","DOIUrl":"10.1016/j.fmre.2024.05.017","url":null,"abstract":"<div><div>Photocatalytic water splitting technology can directly convert solar energy into H<sub>2</sub> via a zero-carbon route, offering a sustainable solution for solar utilization and H<sub>2</sub> supply. Among various developed photocatalysts, Z-scheme heterojunction mimicking natural photosynthesis by combining two dissimilar semiconductors for redox reactions in series has unequivocally demonstrated its superiority in enhanced charge transfer, robust redox driving force, and wide optical absorption range. A comprehensive understanding on the fundamental principles of interface engineering between semiconductor components is the key to construct an efficient Z-scheme heterojunction. By focusing on different types of semiconductors, this article thoroughly expounds the coupling principles of components in binary mediator-free and ternary solid-mediator Z-scheme heterojunctions for photocatalytic water splitting, from the viewpoint of band structure alignment and interfacial electric field design. In addition to the well summarized research progresses in recent years, perspectives on the challenges and opportunities for developing advanced Z-scheme heterojunctions are provided.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 5","pages":"Pages 2204-2208"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141410348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Significant downregulation of Alzheimer's amyloid-β levels enabled by engineered DNA nanomaterials 工程 DNA 纳米材料显著降低阿尔茨海默氏症淀粉样蛋白-β的水平

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2025-09-01 DOI: 10.1016/j.fmre.2024.03.017

Yao Sun , Jing Sun , Yang Feng , Yi Zhang , Jingjing Li , Fan Wang , Mark Loznik , Yang Tian , Hongjie Zhang , Andreas Herrmann , Kai Liu , Can Zhang

{"title":"Significant downregulation of Alzheimer's amyloid-β levels enabled by engineered DNA nanomaterials","authors":"Yao Sun , Jing Sun , Yang Feng , Yi Zhang , Jingjing Li , Fan Wang , Mark Loznik , Yang Tian , Hongjie Zhang , Andreas Herrmann , Kai Liu , Can Zhang","doi":"10.1016/j.fmre.2024.03.017","DOIUrl":"10.1016/j.fmre.2024.03.017","url":null,"abstract":"<div><div>Although there are no effective therapies to block or reverse Alzheimer's disease (AD) progression at present, a promising therapeutic strategy is to reduce levels of amyloid-β (Aβ) proteins, which drive the formation of amyloid plaque, a primary hallmark in AD brains. Herein, we report that amphiphilic lipid-DNA molecules (LD) were designed by incorporating a long alkyl chain into the nucleotide base. It significantly down-regulated Alzheimer's Aβ levels in vivo and in vitro. In contrast to small-molecule chemical drugs and antibody therapies, the assembled DNA nanoparticles allowed them to effectively cross the blood-brain barrier (BBB) and accumulate in the brain, increasing the therapeutic effects. Notably, lipid-DNA downregulated the levels of Aβ peptides significantly in vitro. AD mice model experiments demonstrated that the LD-treated groups exhibited a rapid cognition behavioral improvement, which was associated with brain engagement of LD and reduced Aβ levels. Thus, the molecularly engineered DNA nanomaterials effectively regulated Aβ peptides. This work might provide a promising DNA engineering strategy for AD treatment.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 5","pages":"Pages 2241-2247"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140407646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global patterns and drivers of dissolved organic matter across Earth systems: Insights from H/C and O/C ratios 地球系统中溶解有机物的全球模式和驱动因素：从H/C和O/C比率看问题

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2025-09-01 DOI: 10.1016/j.fmre.2023.11.018

Ang Hu , Lei Han , Xiancai Lu , Ganlin Zhang , Jianjun Wang

{"title":"Global patterns and drivers of dissolved organic matter across Earth systems: Insights from H/C and O/C ratios","authors":"Ang Hu , Lei Han , Xiancai Lu , Ganlin Zhang , Jianjun Wang","doi":"10.1016/j.fmre.2023.11.018","DOIUrl":"10.1016/j.fmre.2023.11.018","url":null,"abstract":"<div><div>Dissolved organic matter (DOM) is ubiquitous and contains a complex pool of thousands of distinct molecules, and their chemical characteristics help us inform the fate of global carbon. However, a more holistic perspective of the molecular characteristics of DOM and underlying mechanisms across Earth systems and climates remains under study. Here, we present a comprehensive analysis of the molecular characteristics of DOM using two abundance-weighted average indices, i.e., H/C and O/C ratios, by compiling 2,995 samples from 317 studies covering waters, land, plant, petroleum, and atmosphere systems and climatic regions from the tropics to tundra. H/C ratios are lower on average in waters (H/C = 1.15 ± 0.005) and land (H/C = 1.20 ± 0.010) than in the other systems, while their O/C ratios rank between plant and atmosphere systems. In the waters and land systems, the H/C ratios of DOM vary from the highest to the lowest in the habitats of the land-to-ocean continuum generally as snow > glacier > marine ≥ freshwater/soil > groundwater. The H/C ratios show predictably U-shaped patterns along latitudinal gradients, indicating the lowest abundance of more hydrogen-saturated molecules at mid-latitudes of approximately 40°-50° in river water, lake water, and forest soil. The two ratios are primarily controlled by environmental factors such as pH, dissolved oxygen, and carbon and nitrogen contents. We further unveil additional and considerable links between the ratios and the extremes of climatic factors such as precipitation of warmest quarter and maximum temperature of warmest month. Our synthesis provides molecular-level perspectives to characterize the global distribution and underlying drivers of DOM, which is complementary for our understanding of global carbon cycle processes under future global change.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 5","pages":"Pages 2121-2132"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139632461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0