Fundamental Research最新文献

{"title":"TOC","authors":"","doi":"10.1016/S2667-3258(26)00771-5","DOIUrl":"10.1016/S2667-3258(26)00771-5","url":null,"abstract":"","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 5","pages":"Pages I-IV"},"PeriodicalIF":6.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perovskite fluid dynamics","authors":"Changshun Chen,&nbsp;Yingdong Xia,&nbsp;Yonghua Chen","doi":"10.1016/j.fmre.2025.08.007","DOIUrl":"10.1016/j.fmre.2025.08.007","url":null,"abstract":"<div><div>The phase transition of perovskite thin films is inherently rapid and highly sensitive to multiple factors. Fluid dynamics has emerged as a powerful framework for elucidating the crystallization and phase transformation processes in perovskites. It governs solute transport, energy dissipation pathways, and mass transfer efficiency, thereby exerting a significant influence on nucleation behavior and crystal growth dynamics. These factors are critical for optimizing film morphology and enhancing device performance in large-area perovskite modules. In this perspective, we first explore the regulatory role of fluid dynamics across distinct phase transition stages and the underlying mechanisms. Then, its practical value in improving film uniformity and optoelectronic performance is examined, with particular emphasis on controlling crystal growth orientation and enhancing structural consistency. Such regulation is considered beneficial for improving device performance and ensuring long-term operational stability under ISOS protocols. Finally, we outline emerging opportunities in solution flow control, crystallization induction, defect passivation, and structural design. These insights offer promising directions for addressing key challenges in stability and scalable fabrication, thereby advancing the development of low-cost, manufacturable perovskite technologies.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 5","pages":"Pages 3267-3270"},"PeriodicalIF":6.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly selective electrochemical synthesis of ClO2 from chlorite with Ti4O7 for rapid pollutants degradation and safe disinfection","authors":"Shengxi Zhao,&nbsp;Xiang Zhang,&nbsp;Minzi Liao,&nbsp;Jie Dai,&nbsp;Shuxiang Wang,&nbsp;Hao Li,&nbsp;Lizhi Zhang","doi":"10.1016/j.fmre.2025.01.002","DOIUrl":"10.1016/j.fmre.2025.01.002","url":null,"abstract":"<div><div>Industrial synthesis of chlorine dioxide (ClO₂) is infrastructure-demanding and presents significant safety and transportation challenges. The electrochemical method, while offering an on-site ClO₂ production alternative, suffers from risky chlorate (ClO₃⁻) generation, even when using a widely-utilized noble metal-based dimensionally stable anode (DSA). In this study, we report that a Ti₄O₇ anode can efficiently convert chlorite (ClO₂⁻, 25 mmol L⁻¹) to ClO₂ with an impressive selectivity of 99% at 10 mA cm⁻². Unlike DSA, which generates abundant free hydroxyl radicals (•OH) that over-oxidize ClO₂⁻ into ClO₃⁻ via a 2:1 stoichiometry, the Ti₄O₇ anode confines •OH onto its surface, facilitating selective ClO₂⁻ oxidation through single-electron transfer reaction. With this novel Ti₄O₇ anode, a portable ClO₂ gas generator was designed to continuously deliver high-purity and cost-effective ClO₂ at a rate of 3.30 g h⁻¹ with high stability over 5-day operational period, and thus is very promising for rapid water pollutants (sulfamethazine, ciprofloxacin, cephalexin, tetracycline, and carbamazepine) degradation and safe disinfection against pathogens (<em>E. coli, S. aureus</em>, and <em>AR E. coli</em>) in minutes with minimal chlorinated byproducts.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 5","pages":"Pages 2942-2949"},"PeriodicalIF":6.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-performance seismic response analysis for mega-scale integrated underground-aboveground structure system in saturated sand","authors":"Jia-Ke Yu,&nbsp;Rong-Xin Wang,&nbsp;Jian-Min Zhang,&nbsp;Rui Wang","doi":"10.1016/j.fmre.2025.06.013","DOIUrl":"10.1016/j.fmre.2025.06.013","url":null,"abstract":"<div><div>With rapid urbanization, major cities are witnessing mass development of large integrated underground-aboveground structure systems. A notable example is the Beijing Municipal Administrative Center Transport Complex (BMACTC), which boasts an underground area spanning 1.28 million square meters. The soil-structure interaction and mutual interaction among structure components, particularly in liquefiable sites, pose significant challenges for seismic design. To address these challenges, this study proposes a high-performance solid-fluid coupled elastoplastic simulation method for earthquake geotechnical engineering, and applies it to achieve integrated simulation of BMACTC with a finite element method (FEM) model of over 16 million degrees of freedom. The analysis unveils the seismic response of underground structures under the influence of large openings, aboveground structures, and cross-section changes. Saturated sand layers experience significant weakening under seismic loading, with a maximum excess pore pressure ratio of nearly 0.5. The large openings significantly increase the nearby horizontal deformation and uplift of the underground structure. Moderate height and tall aboveground structures have different effects on the deformation of the underground structure, which is related to the system natural frequency and input motion frequency. The change in cross section geometry affects the deformation and internal force in the transition zone between the different sections.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 5","pages":"Pages 3251-3266"},"PeriodicalIF":6.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of minerals in prebiotic evolution: Implications for identifying worlds with the potential for life’s origin","authors":"Houze Lu,&nbsp;Yan Li,&nbsp;Dehai Liang","doi":"10.1016/j.fmre.2026.07.002","DOIUrl":"10.1016/j.fmre.2026.07.002","url":null,"abstract":"<div><div>Understanding the origin of life requires explaining how abiotic molecules transitioned into the first living systems within plausible geological settings. Increasing evidence suggests minerals as active participants in prebiotic evolution. By adsorbing and concentrating reactants, catalyzing key reactions, stabilizing intermediates, and providing protective microenvironments, minerals may have helped to overcome thermodynamic and kinetic barriers, thereby enabling a cascade of prebiotic reactions to proceed toward the earliest life. In this review, we synthesize current experimental and theoretical advances to examine the contributions of minerals across the successive stages of prebiotic chemistry, from the formation of simple precursors and biomolecular monomers to polymerization, compartmentalization, and protocell assembly. We propose that these processes were unlikely to have unfolded within a single environment because different prebiotic reactions imposed distinct physicochemical demands. Instead, prebiotic evolution probably proceeded through complementary reactions distributed among multiple geological settings, including hydrothermal vents, terrestrial hot springs, and potentially extraterrestrial niches, with intermediates being preserved and then transported across spatial and temporal geological scales to link otherwise disconnected evolutionary stages. Building on this view, we identify specific minerals capable of facilitating key reactions at different stages of prebiotic evolution and propose that their combined occurrence as characteristic mineral assemblages may provide mineralogical indicators for assessing a planet’s geological potential to support life’s emergence. This mineral-centered perspective complements conventional biosignature-based approaches in astrobiology, and highlights mineralogy as a powerful tool in the ongoing search for habitable worlds and life beyond Earth.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 5","pages":"Pages 2812-2822"},"PeriodicalIF":6.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In situ 3D bioprinting: The future of regenerative medicine","authors":"Jianhao Huang,&nbsp;Guangxin Zhou,&nbsp;Qing Jiang,&nbsp;Lan Li","doi":"10.1016/j.fmre.2025.06.004","DOIUrl":"10.1016/j.fmre.2025.06.004","url":null,"abstract":"<div><div>3D bioprinting is utilized to design and construct scaffolds with scalable forms and physicochemical properties. Recently, this technology has been extensively studied in the field of biology and has achieved promising results in tissue and organ repair. However, challenges such as shape mismatch, unstable adhesion, and contamination arise during the transition from externally printed scaffolds to their internal transplantation, thereby limiting clinical applications. Compared to traditional 3D bioprinting, <em>in situ</em> 3D bioprinting offers enhanced tissue integration and surface construction capabilities, demonstrating greater clinical potential. Nevertheless, it places higher demands on printing technology and bio-ink. This article summarizes the methods and characteristics of <em>in situ</em> 3D bioprinting, and introduces research on the composition and reactivity of bio-inks. The latest progress in tissue repair using <em>in situ</em> bioprinting is highlighted. Further research in 3D bioprinting for tissue engineering, encompassing defect model scanning, printing platform construction, printing techniques, ink combinations, and large tissue printing, is ongoing. <em>In situ</em> 3D bioprinting holds promise as a novel and effective treatment method for future clinical applications.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 5","pages":"Pages 3156-3171"},"PeriodicalIF":6.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Signs of extraterrestrial life and evolution of habitable environments","authors":"Zengqian Hou,&nbsp;Yuming Wang","doi":"10.1016/j.fmre.2026.08.002","DOIUrl":"10.1016/j.fmre.2026.08.002","url":null,"abstract":"","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 5","pages":"Pages 2765-2766"},"PeriodicalIF":6.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Speeding up adiabatic holonomic quantum gates via π-pulse modulation","authors":"Jiang Zhang,&nbsp;Tonghao Xing,&nbsp;Guilu Long","doi":"10.1016/j.fmre.2025.05.005","DOIUrl":"10.1016/j.fmre.2025.05.005","url":null,"abstract":"<div><div>Holonomic quantum computation (HQC) offers an inherently robust approach to quantum gate implementation by exploiting quantum holonomies. While adiabatic HQC benefits from robustness against certain control errors, its long runtime limits practical utility due to increased exposure to environmental noise. Nonadiabatic HQC addresses this issue by enabling faster gate operations but compromises robustness. In this work, we propose a scheme for fast holonomic quantum gates based on the <span><math><mi>π</mi></math></span>-pulse method, which accelerates adiabatic evolution while preserving its robustness. By guiding the system Hamiltonian along geodesic paths in the parameter space and applying phase-modulating <span><math><mi>π</mi></math></span> pulses at discrete points, we realize a universal set of holonomic gates beyond the conventional adiabatic limit. Our scheme allows for arbitrary single-qubit and two-qubit controlled gates within a single-loop evolution and provides additional tunable parameters for flexible gate design. These results demonstrate a promising path toward high-fidelity, fast, and robust quantum computation.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 5","pages":"Pages 2869-2877"},"PeriodicalIF":6.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between chronic respiratory diseases and the attributable risk of long-term exposure to atmospheric particulate matters among middle-aged and elderly Chinese population","authors":"Wei-jie Guan,&nbsp;Shu-jun Guo,&nbsp;Li-lian Zeng,&nbsp;Jing Wei,&nbsp;De-jian Zhao,&nbsp;Rui-lin Meng,&nbsp;Yan-jun Xu,&nbsp;Yun-hong Lv,&nbsp;Chuan Li,&nbsp;Hong-ye Zhou,&nbsp;Jia-hui He,&nbsp;Li-feng Lin,&nbsp;Xue-yan Zheng","doi":"10.1016/j.fmre.2025.04.013","DOIUrl":"10.1016/j.fmre.2025.04.013","url":null,"abstract":"<div><div>Chronic respiratory diseases (CRDs) mainly consist of chronic obstructive pulmonary disease (COPD), asthma and chronic bronchitis. The attributable risks of CRDs associated with long-term exposure to ambient particulate matters (PMs, aerodynamic diameter ≤1, 2.5 and 10 µm: PM₁, PM_2.5 and PM₁₀) are unclear, particularly in developing countries. We determined the association between long-term exposure to PMs and CRDs in the middle-aged and elderly Chinese population and their corresponding population-attributable fractions (PAF). We conducted a <em>COPD Surveillance</em> study in Guangdong, China. We derived the averaged 722-day exposure estimates of PM₁, PM_2.5 and PM₁₀ at 1 km × 1 km resolution at individual residential addresses between 2013 and 2019. The associations between PMs and CRDs were estimated by logistic regression models. We calculated the PAF of CRDs attributable to long-term PM exposures. We included 7371 participants aged 40 years or greater, among whom 1430 (19.40%), 736 (9.99%), 731 (9.92%) and 313 (4.25%) had CRDs, COPD, chronic bronchitis and asthma, respectively. Each 10 µg/m³ increment of PMs was positively associated with the proportion of patients with CRDs, COPD, chronic bronchitis and asthma. The associations were more prominent in participants residing in rural areas and exposed to biomass fuel. The PAF of CRDs associated with PM₁, PM_2.5 and PM₁₀ was 19.09% (95%CI: 12.41%∼25.02%), 18.98% (95%CI: 12.90%∼24.90%) and 21.40% (95%CI: 13.84%∼27.67%), respectively. The PAF of COPD associated with PMs was highest, followed by asthma and chronic bronchitis. In summary, ambient PM exposure is linked to a heightened risk of CRDs and accounts substantially for CRDs among the middle-aged and elderly population.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 5","pages":"Pages 3408-3416"},"PeriodicalIF":6.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic delivery of stealth adenoviral vector to reinvigorate antitumor immunity by PD-L1 genome editing and TIGIT/CD155 blocking","authors":"Ming Wu,&nbsp;Cao Zhang,&nbsp;Aoxue Zhong,&nbsp;Hao Li,&nbsp;Yang Zhou,&nbsp;Xiaoyuan Zheng,&nbsp;Youshi Zheng,&nbsp;Yuting Zhang,&nbsp;Yanbing Cao,&nbsp;Zhenli Li,&nbsp;Cuilin Zhang,&nbsp;Xiaomo Wu,&nbsp;Dong Cen,&nbsp;Xiaolong Liu","doi":"10.1016/j.fmre.2025.04.015","DOIUrl":"10.1016/j.fmre.2025.04.015","url":null,"abstract":"<div><div>Treatment with combined immune checkpoint blockade (CICB) has been considered as an effective approach to increase the objective response rate for cancer immunotherapy, but at the cost of significantly increased immune-related adverse events (irAEs) and also sufferings from drug resistance due to the transitory working manner of antibody-based ICB inhibitors. We introduce an antibody-independent CICB strategy using an adenoviral vector (sgCas9-Adv@TCM) that delivers a PD-L1 targeted CRISPR/Cas9 system, with a cell membrane cloak presenting TIGIT proteins. The vector could effectively accumulate in tumors, allowing permanent PD-L1 genome editing and TIGIT/CD155 blocking through systemic administration while evading detection and degradation by the immune system. The sgCas9-Adv@TCM vector achieved complete tumor regression in 80% of mice in a subcutaneous hepatocellular carcinoma (HCC) model by globally reshaping the tumor immune microenvironment to elicit robust anti-tumor immunity. Furthermore, sgCas9-Adv@TCM was proven to be still competent and even superior to the standard FDA-approved CICB regimen of the combined anti-PD-L1 and anti-TIGIT in suppressing tumor progression, prolonging survival, and inducing immunological memory of mice in the orthotopic HCC model, but with a much lower risk of irAEs. In addition, the clinical translation potential of sgCas9-Adv@TCM was further validated in the patient-derived organoid (PDO) and patient-derived xenograft (PDX) models from patients diagnosed with HCC. Thus, this study presents a safe and highly efficient “stealth” adenoviral vector with improved CICB features for cancer treatment.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 5","pages":"Pages 3417-3430"},"PeriodicalIF":6.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}