Fundamental Research最新文献

{"title":"Accelerating amine-based CO2 capture with machine learning: From molecular screening to process optimization","authors":"Ping Yang ,&nbsp;Xiaoman Yu ,&nbsp;Kyriakos C. Stylianou ,&nbsp;Liang Huang ,&nbsp;Qiang Wang","doi":"10.1016/j.fmre.2025.12.022","DOIUrl":"10.1016/j.fmre.2025.12.022","url":null,"abstract":"<div><div>Amine-based CO₂ capture represents the most mature approach for large-scale carbon reduction, with systems implemented across multiple industrial demonstration projects globally. However, vast chemical spaces encompassing millions of potential formulations and complex multiscale coupling effects pose unprecedented challenges for traditional experimental methods. Machine learning applications have achieved revolutionary advances through differentiated strategies. In liquid amine systems, ensemble learning algorithms delivered breakthrough precision improvements from traditional 4–5% to below 0.93%, while interpretable models revealed that nitrogen atom charge distribution contributes 56% to reaction barriers, enabling rational biphasic solvent design (DETA/DEEA system) that achieved 34% regeneration energy reduction compared to benchmark MEA. For solid amine systems, differential descriptor methods overcame severe overfitting challenges, improving test set performance from <em>R</em>² = 0.5102 to 0.79. Virtual screening of 1.6 million binding sites from the GDB-17 database identified 11% of candidates with stronger CO₂ binding than the industrial benchmark BPEI (−0.04 eV). Among these high-performance candidates, 2642 molecules simultaneously satisfied synthesizability criteria (SAscore &lt; 3.4, GDBscore &gt; 0.64), demonstrating both favorable binding energetics and high experimental feasibility. Critically, mechanistic analysis revealed that support physical properties dominate adsorption performance over amine chemical characteristics, fundamentally transforming material design concepts. Industrial applications demonstrated 35.76% cost reductions through intelligent solvent selection and 15–25% profit improvements through dynamic capture-level optimization combined with market-responsive bidding strategies. Despite these breakthroughs, systematic limitations, including model generalization difficulties, cross-scale integration challenges, and data standardization, persist, requiring physics-constrained algorithms and unified modeling frameworks for laboratory-to-industrial translation. These developments establish machine learning as the core driving force transitioning amine-based CO₂ capture from empirical development toward intelligent design paradigms.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 604-619"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147620747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A governance framework for blockchain-based manufacturing collaborative platform","authors":"Gengzhong Feng ,&nbsp;Zhecheng Wang ,&nbsp;Xi Zhao ,&nbsp;Ningning Liu ,&nbsp;Xiaomin Shi","doi":"10.1016/j.fmre.2024.12.012","DOIUrl":"10.1016/j.fmre.2024.12.012","url":null,"abstract":"<div><div>The traditional manufacturing collaborative platforms (MCPs) face challenges of weak trust and innovation inhibition in the transformation and upgrading of the global industrial chain. This paper investigates the blockchain-based manufacturing collaborative platforms (BMCPs) as a potential solution. This paper first analyzes the ecological characteristics of MCPs and BMCPs, and puts forward six governance challenges caused by the unique openness, uncertainty and complexity of BMCPs. Then, in order to offer comprehensive and adaptable guidelines for BMCP governance practices, we propose a governance framework with three layers (off-chain community, on-chain DAO, and on-chain contracts) and five dimensions (roles, incentives, communication, decision-making, and value evolution). Finally, based on the value evolution characteristics of BMCPs, we investigate how to apply the proposed governance framework during the start-up and optimization stages of BMCPs. Using member expansion and fault management as two-stage examples, the paper uses a UML sequence diagram to demonstrate how the governance framework works. This study provides a theoretical framework and practical guidance for creating a more transparent, intelligent and sustainable manufacturing ecosystem.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 1123-1135"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147620850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “A green recycling process for spent lithium-ion batteries with extremely low chemical consumption” [Fundamental Research 5 (2025) 2815–2823]","authors":"Weiguang Lv ,&nbsp;Xiaohong Zheng ,&nbsp;Hongbin Cao ,&nbsp;Yue Wang ,&nbsp;Pengge Ning ,&nbsp;Yi Zhang ,&nbsp;Zhi Sun","doi":"10.1016/j.fmre.2025.12.024","DOIUrl":"10.1016/j.fmre.2025.12.024","url":null,"abstract":"","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 1247-1248"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147620884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of Zidovudine as a cardiomyocyte protectant for doxorubicin-induced toxicity through high-throughput phenotypic drug screening","authors":"He Xu ,&nbsp;Hao You ,&nbsp;Jixing Gong ,&nbsp;Ying Zhang ,&nbsp;Jianyong Du ,&nbsp;Xinyu Wang ,&nbsp;Shanshan Gu ,&nbsp;Nan Cao ,&nbsp;Jia Wang","doi":"10.1016/j.fmre.2023.10.010","DOIUrl":"10.1016/j.fmre.2023.10.010","url":null,"abstract":"<div><div>Doxorubicin (DOX) constitutes a cornerstone in cancer chemotherapy, yet its administration is associated with dose-dependent toxicity to the heart, known as doxorubicin-induced cardiotoxicity (DOX-IC). Presently, dexrazoxane stands as the sole approved drug for mitigating DOX-IC; however, its clinical application is restricted due to concerns over severe adversary effects. It is therefore urgent to discover alternative drug candidates to ameliorate DOX-IC. Here, we report the discovery of Zidovudine (ZIDO), a clinically available anti-retroviral medication, as a potent candidate to protect against DOX-IC both <em>in vitro</em> and <em>in vivo</em> by high-throughput phenotypic screening of a library of 1804 Food and Drug Administration (FDA)-approved drugs. Transcriptomic analysis reveals that ZIDO treatment significantly alleviates DOX-induced dysregulation of genes associated with cardiac function and proteotoxic stress. This study sets a paradigm towards discovering novel cardiac protective drugs through repurposing and establishes ZIDO as an agent holding promise for the treatment of DOX-IC patients.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 885-894"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139296761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer-associated fibroblast-derived stanniocalcin 1 promotes cholangiocarcinoma progression and lymph node metastasis","authors":"Jian Yan ,&nbsp;Qinqin Liu ,&nbsp;Gang Xiao ,&nbsp;Jiajia Du ,&nbsp;Caini Yang ,&nbsp;Chaoqun Liu ,&nbsp;Shusheng Lin ,&nbsp;Zhenhua Bai ,&nbsp;Chao Liu ,&nbsp;Jingang Huang ,&nbsp;Rui Zhang","doi":"10.1016/j.fmre.2023.11.022","DOIUrl":"10.1016/j.fmre.2023.11.022","url":null,"abstract":"<div><div>Cholangiocarcinoma (CCA) is a fibroblast-rich tumor. Lymph node metastasis (LNM) is the main prognostic risk factor for CCA. We determined that stanniocalcin 1 (STC1) is highly expressed in cancer-associated fibroblasts (CAFs) with LNM in CCA. However, the roles of CAFs and STC1 in CCA progression and LNM remain unelucidated. Here, we demonstrated that primary CCA tissues with LNM (LN⁺CCA) were enriched with more CAFs and lymphatic vessels than those with LN⁻CCA. LN⁺ CAFs strongly promoted CCA cell migration, invasion, TrEM, and LNM both <em>in vitro</em> and <em>in vivo</em>. LN⁺CAFs exhibited significantly higher STC1 expression than LN⁻CAFs. The <em>in vitro</em> and <em>in vivo</em> results demonstrated that STC1 is mainly responsible for the role of LN⁺CAFs in promoting CCA malignant behavior. Mechanistic studies demonstrated that STC1 activates integrin αVβ3 and its downstream FAK–YAP pathway. Additionally, we found that targeting STC1 and integrin αVβ3 rescued the pro-tumor effects of CAF on CCA <em>in vitro</em> and <em>in vivo</em>. Therefore, CAF-derived STC1 predicts LNM and is a potential therapeutic target in CCA.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 1187-1202"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139831018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organic carbon sink dynamics and carbon sink-source balance in global lakes during the Anthropocene","authors":"Fanfan Meng ,&nbsp;Ang Hu ,&nbsp;Hao Wu ,&nbsp;Kyoung-Soon Jang ,&nbsp;Bo Liu ,&nbsp;Tianheng Gao ,&nbsp;Qinglong Wu ,&nbsp;Jianjun Wang","doi":"10.1016/j.fmre.2024.04.018","DOIUrl":"10.1016/j.fmre.2024.04.018","url":null,"abstract":"<div><div>The carbon burial and greenhouse gas emissions of lakes are pivotal in the global carbon cycle to offset or accelerate global warming. However, their balance or the magnitude of anthropogenic increase of carbon burial remains uncertain in global lakes. Here, we quantified the carbon sink dynamics and the sink-source balance in global lakes with effect-size metrics, that is, the log-response ratio of organic carbon burial between post-1950 and pre-1900 periods and the carbon balance ratio between carbon burial and greenhouse gas emissions, respectively. The organic carbon burial ratios revealed an average increase of 2.45 times in carbon burial rates during the Anthropocene, while the carbon balance ratios were negative in 82.68% of lakes, indicating that most lakes had lower burial rates than emission rates and acted as carbon sources rather than carbon sinks. The organic carbon burial ratios exhibited a significantly decreasing latitudinal trend and were mainly influenced by lake’s trophic state with the explained variation of 44.79%. They were also indirectly influenced by climate, lake morphometry, and catchment properties through their interactions with the lake’s trophic state. The carbon balance ratios, however, showed a nonsignificant latitudinal trend. They were primarily affected by lake catchment properties with the explained variation of 26.21% and were also indirectly affected by climate variables via the interactions with catchment properties. Overall, our study highlights that human activities such as lake eutrophication and catchment changes have altered the carbon sink and source in global lakes during the Anthropocene, and are essential drivers for future evaluations of lake carbon budgets.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 974-985"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141023177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating tipping points: A complex systems framework for anticipating lake ecosystem collapse","authors":"Hanxiao Zhang ,&nbsp;Hui Li ,&nbsp;Shouliang Huo ,&nbsp;Zhifeng Yang ,&nbsp;Fengchang Wu","doi":"10.1016/j.fmre.2025.07.004","DOIUrl":"10.1016/j.fmre.2025.07.004","url":null,"abstract":"<div><div>Lake ecosystems are susceptible to catastrophic risks, characterized by abrupt and large-scale transitions that substantially degrade ecological integrity and compromise provision of essential ecosystem services. To better understand these risks, a systems science perspective is essential, one that captures the complexity, nonlinearity, and emergent properties inherent in lake ecosystem dynamics. In this review, we synthesize the current understanding of catastrophic risks in lake ecosystems through complex adaptive systems and emphasize the feedback loops, bifurcations, and tipping points that drive regime shifts and ecosystem reorganization. Advancements in early warning signals offer promise for proactive risk management. Temporal indicators, spatial patterns, and network-based metrics can foreshadow tipping points. However, their application requires context-specific validation, because lakes exhibit heterogeneous responses to stressors. Key drivers such as eutrophication, climate change, invasive species, and anthropogenic-driven land use change interact synergistically, exacerbating systemic risks. Effective management requires resilience-building strategies, including adaptive governance, nutrient control, and restoration of buffer mechanisms. We advocate integrating dynamic modeling with multiscale monitoring to refine and optimize interventions. Future research directions should focus on unifying empirical data with theoretical frameworks, increasing the reliability of early warning signals, addressing the cascading effects of global change, and the application of artificial intelligence in monitoring and early warning. By integrating systems theory with applied limnology, this review helps guide research and policy efforts toward mitigating catastrophic risks in lake ecosystems.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 592-603"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147620741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wavelength-selective thermal nonreciprocity barely improves sky radiative cooling","authors":"Zihe Chen ,&nbsp;Shilv Yu ,&nbsp;Jinlong Ma ,&nbsp;Bin Xie ,&nbsp;Sun-Kyung Kim ,&nbsp;Run Hu","doi":"10.1016/j.fmre.2024.12.019","DOIUrl":"10.1016/j.fmre.2024.12.019","url":null,"abstract":"<div><div>Sky radiative cooling has showcased great potential for passive refrigeration without extra energy consumption, while its cooling power and efficiency are confined by Kirchhoff's law, that is, the emissivity is equal to the absorptivity. The recent development of thermal nonreciprocity that breaks the limitations of Kirchhoff's law, especially in a broadband manner, makes nonreciprocal radiative cooling (NRC) possible. However, as there are few reports on NRC either theoretically or experimentally, it is necessary to evaluate the feasibility and worthiness of developing NRC. Here, we discussed the effects of NRC at around room temperature (298.15 K) from three perspectives: ideal selective radiators, non-selective radiators, and colored radiators, which are the current primary radiative coolers. Counterintuitively, we found that introducing thermal nonreciprocity barely improves sky radiative cooling, and only in the atmospheric window (8–13 µm) even leads to a negative gain. The current findings break the intuition of NRC and offer a negative proof for the development of NRC devices.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 718-724"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147620743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robust strong coupling of single quantum emitters with plasmonic nanocavity on one-dimensional photonic crystal substrate","authors":"Bowen Fu ,&nbsp;Longlong Yang ,&nbsp;Yu Yuan ,&nbsp;Jingnan Yang ,&nbsp;Hancong Li ,&nbsp;Zetao Fan ,&nbsp;Sai Yan ,&nbsp;Guowei Lu ,&nbsp;Douguo Zhang ,&nbsp;Qihuang Gong ,&nbsp;Xiulai Xu","doi":"10.1016/j.fmre.2025.04.012","DOIUrl":"10.1016/j.fmre.2025.04.012","url":null,"abstract":"<div><div>The plasmonic nanocavity with extremely localized field distribution can facilitate strong coupling with emitters at the level of single quanta. However, the dramatic variation of the plasmon field with distance on the surface of nanocavity makes the strength of the interaction very sensitive to the location of the individual emitter. Here, we present a new strategy that achieves room-temperature strong coupling by integrating a single CdSe/ZnS quantum dot with a bowtie-structured plasmonic nanocavity on a one-dimensional photonic crystal (1DPC) substrate. This kind of hybrid cavity enables a more uniform field distribution in the nanogap, which is more robust and stable. The Rabi splitting with single exciton reached <span><math><mo>∼</mo></math></span>170 meV and the lifetime of photon emission is reduced by <span><math><mo>∼</mo></math></span>5 times. This work provides an new way to construct solid-state cavity quantum electrodynamic system in strong coupling region at room temperature.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 725-732"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147620744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effects of green development policies on energy security and carbon emissions reduction","authors":"Ying Fan ,&nbsp;Xu Xiao ,&nbsp;Yongna Yuan","doi":"10.1016/j.fmre.2024.12.016","DOIUrl":"10.1016/j.fmre.2024.12.016","url":null,"abstract":"<div><div>Considering the complex international relationships and unstable trade relations involved, examining the effects of green development policies on energy security and carbon emissions reduction is essential for advancing China's carbon peak and neutrality goals. This study constructs a dynamic computable general equilibrium (CGE) model that includes a resource exhaustion module and an endogenous electricity technology module and evaluates the effects of green development policies in the context of a possible oil-import supply disruption shock in China. The results show that resource and oil taxes will generate temporary double dividends but have limited effects on carbon emission and energy consumption reduction. Second, carbon pricing causes high GDP loss while lowering energy consumption and carbon emissions. Third, improving non-fossil electricity investment has a positive effect on carbon emissions reduction, non-fossil energy development and long-term economic growth due to learning-by-doing effects; however, over-investment would cause GDP loss. Fourth, structural adjustment in end-use energy consumption and advancements in industrial electrification could drive the low carbon transformation of the economy from the demand side, which can have considerable economic benefits while achieving carbon reduction and improving energy security. Fifth, single policy characteristics and policy interactions should be considered when multiple green development goals exist. The harmonious design of a combination of supply- and demand-side policies can improve carbon mitigation and energy transformation efficiency.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 1136-1148"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147620851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}