Fundamental Research最新文献_第3页

A simulation optimization method for coordination of production, transportation and sales 生产、运输和销售协调的仿真优化方法

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-03-01 DOI: 10.1016/j.fmre.2023.06.013

Yi Zheng, Ming Lei, Yijie Peng

{"title":"A simulation optimization method for coordination of production, transportation and sales","authors":"Yi Zheng, Ming Lei, Yijie Peng","doi":"10.1016/j.fmre.2023.06.013","DOIUrl":"10.1016/j.fmre.2023.06.013","url":null,"abstract":"<div><div>This study considers a problem of coordinating production, transportation and sales in a multi-echelon supply chain network. A simulation model is built to generate the random customer demands at different locations, which are affected by a marketing strategy. Customer demands need to be satisfied by the supply chain through production, transportation and distribution. The optimization problem for coordination of production, transportation and distribution is first formulated as a linear programming with demands as input parameters in the constraint. Our objective is to maximize the expectation of the optimal profit of the supply chain given random demands by selecting an optimal marketing strategy. A simulation optimization technique is proposed to control the generation of random demands and solve the linear programming for efficiently learning the optimal marketing strategy. Numerical results show that our method can significantly improve the expected profit of the supply chain and reduce the computational burden of solving linear programming for achieving a given level of probability of correct selection of the optimal marketing strategy. Furthermore, we extend the optimization problem to a mixed integer programming and also demonstrate the computational efficiency of our proposed method.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 2","pages":"Pages 473-485"},"PeriodicalIF":6.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135200209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A catalogue of virulence strategies mediated by phytopathogenic effectors 植物病原菌效应器介导的毒力策略目录

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-03-01 DOI: 10.1016/j.fmre.2023.10.026

Gan Ai , Hao Peng , Weiye Pan , Yuke Li , Zhirui Wan , Zhiyuan Yin , Danyu Shen , Suomeng Dong , Yuanchao Wang , Daolong Dou

{"title":"A catalogue of virulence strategies mediated by phytopathogenic effectors","authors":"Gan Ai , Hao Peng , Weiye Pan , Yuke Li , Zhirui Wan , Zhiyuan Yin , Danyu Shen , Suomeng Dong , Yuanchao Wang , Daolong Dou","doi":"10.1016/j.fmre.2023.10.026","DOIUrl":"10.1016/j.fmre.2023.10.026","url":null,"abstract":"<div><div>Plant diseases cause dramatic economic loss, posing a major challenge to modern agriculture. Plant pathogenic organisms secret effectors that utilize fascinating and intricate stratagems to facilitate infection. The consequences of plant-pathogen interactions are largely determined by effectors. The effector research has made great strides since its inception in the 1990s and the importance of effectors is increasingly noticed. Molecular investigation of effectors has provided critical insights into how plant pathogens manipulate their hosts to cause diseases. Thus far, numerous excellent reviews concerning effectors have focused on their targeting host pathways, recognition by host receptors, and evasion mechanisms, but few have ever summarized all known effector action modes. Here, we distinguish ten different stratagems of effector function from all types of pathogens, including damage, inhibition, hijacking, promotion, subversion, mimicry, reprogramming, evasion, decoying, and adaption. Furthermore, we discuss examples of these ten stratagems, refine the effector definition, and propose future directions of phytopathogenic effector research.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 2","pages":"Pages 663-673"},"PeriodicalIF":6.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140462818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of GPI-anchored membrane-bound alkaline phosphatase in the mode of action of Bt Cry1A toxins in the diamondback moth

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-03-01 DOI: 10.1016/j.fmre.2024.05.007

Dan Sun , Qiuchen Xu , Le Guo , Yang Bai , Xuping Shentu , Xiaoping Yu , Neil Crickmore , Xuguo Zhou , Alejandra Bravo , Mario Soberón , Youjun Zhang , Zhaojiang Guo

{"title":"The role of GPI-anchored membrane-bound alkaline phosphatase in the mode of action of Bt Cry1A toxins in the diamondback moth","authors":"Dan Sun , Qiuchen Xu , Le Guo , Yang Bai , Xuping Shentu , Xiaoping Yu , Neil Crickmore , Xuguo Zhou , Alejandra Bravo , Mario Soberón , Youjun Zhang , Zhaojiang Guo","doi":"10.1016/j.fmre.2024.05.007","DOIUrl":"10.1016/j.fmre.2024.05.007","url":null,"abstract":"<div><div>The insecticidal Cry proteins produced by the bacterium <em>Bacillus thuringiensis</em> (Bt) are extensively used for pest control in formulated sprays and in genetically modified crops, but resistance to Bt toxins threatens their sustainable use in agriculture. Understanding the molecular mechanisms involved in Bt pathogenesis is crucial for the development of effective resistance management strategies. Previously, we showed a strong correlation between Cry1Ac resistance in <em>Plutella xylostella</em> (L.) and down-regulation of the glycosylphosphatidylinositol (GPI)-anchored membrane-bound alkaline phosphatase (mALP) and aminopeptidase (APN) and members of the ATP-binding cassette (ABC) transporter subfamily C (ABCC), but we do not yet have a clear understanding of the relative contribution of each midgut receptor type. Here, a <em>P. xylostella</em> strain homozygous for the <em>PxmALP</em> gene knockout was generated using CRISPR/Cas9 and the results showed that this strain had a 294-fold resistance to Cry1Ac toxin and 394-fold cross-resistance to Cry1Ab. Moreover, a triple knockout strain lacking <em>PxmALP, PxABCC2</em>, and <em>PxABCC3</em> exhibited 9,660-fold resistance to Cry1Ac and 5,662-fold cross-resistance to Cry1Ab. These resistance levels surpassed those observed in the previously described double <em>PxABCC2</em> and <em>PxABCC3</em> knockout mutant, revealing a functional redundancy between ABC transporters and PxmALP<em>.</em> In addition, the activity of Cry1A toxins against Sf9 cells expressing PxmALP, PxABCC2 or PxABCC3 confirmed that each of these can act as a functional receptor. Our findings are crucial for unraveling the relative role of multiple receptors and the molecular mechanisms underlying Bt resistance in insects.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 2","pages":"Pages 674-682"},"PeriodicalIF":6.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The theory, technology, and application of terahertz metamaterial biosensors: A review

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-03-01 DOI: 10.1016/j.fmre.2024.11.008

Xiaoke Wei , Chuanlu Ren , Bingwei Liu , Yan Peng , Songlin Zhuang

{"title":"The theory, technology, and application of terahertz metamaterial biosensors: A review","authors":"Xiaoke Wei , Chuanlu Ren , Bingwei Liu , Yan Peng , Songlin Zhuang","doi":"10.1016/j.fmre.2024.11.008","DOIUrl":"10.1016/j.fmre.2024.11.008","url":null,"abstract":"<div><div>Terahertz metamaterial biosensors combine terahertz time-domain spectroscopy with metamaterial sensing to provide a sensitive detection platform for a variety of targets, including biological molecules, proteins, cells, and viruses. These biosensors are characterized by their rapid response, sensitivity, non-destructive, label-free operation, minimal sample requirement, and user-friendly design, which also allows for integration with various technical approaches. Advancing beyond traditional biosensors, terahertz metamaterial biosensors facilitate rapid and non-destructive trace detection in biomedical applications, contributing to timely diagnosis and early screening of diseases. In this paper, the theoretical basis and advanced progress of these biosensors are discussed in depth, focusing on three key areas: improving the sensitivity and specificity, and reducing the influence of water absorption in biological samples. This paper also analyzes the potential and future development of these biosensors for expanded applications. It highlights their potential for multi-band tuning, intelligent operations, and flexible, wearable biosensor applications. This review provides a valuable reference for the follow-up research and application of terahertz metamaterial biosensors in the field of biomedical detection.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 2","pages":"Pages 571-585"},"PeriodicalIF":6.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering exosomes and exosome-like nanovesicles for improving tissue targeting and retention

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-03-01 DOI: 10.1016/j.fmre.2024.03.025

Lanya Li , Fei Wang , Dashuai Zhu , Shiqi Hu , Ke Cheng , Zhenhua Li

{"title":"Engineering exosomes and exosome-like nanovesicles for improving tissue targeting and retention","authors":"Lanya Li , Fei Wang , Dashuai Zhu , Shiqi Hu , Ke Cheng , Zhenhua Li","doi":"10.1016/j.fmre.2024.03.025","DOIUrl":"10.1016/j.fmre.2024.03.025","url":null,"abstract":"<div><div>Exosomes are natural nano-size particles secreted by human cells, containing numerous bioactive cargos. Serving as crucial mediators of intercellular communication, exosomes are involved in many physiological and pathological processes, such as inflammation, tissue injury, cardiovascular diseases, tumorigenesis and tumor development. Exosomes have exhibited promising results in the diagnosis and treatment of cancer, cardiovascular diseases and others. They are a rapidly growing class of drug delivery vehicles with many advantages over conventional synthetic carriers. Exosomes used in therapeutic applications encounter several challenges, such as the lack of tissue targeting capabilities and short residence time. In this review, we discuss recent advances in exosome engineering to improve tissue targeting and describe the current types of engineered exosome-like nanovesicles, and summarize their preclinical applications in the treatment of diseases. Further, we also highlight the latest engineering strategies developed to extend exosomes retention time in vivo and exosome-like nanovesicles.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 2","pages":"Pages 851-867"},"PeriodicalIF":6.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supply chain resilience: A review from the inventory management perspective

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-03-01 DOI: 10.1016/j.fmre.2024.08.002

Ying Guo , Fang Liu , Jing-Sheng Song , Shuming Wang

引用次数: 0

Accelerating the offshore CCUS to carbon-neutral China

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-03-01 DOI: 10.1016/j.fmre.2022.10.015

Jianghui Li

{"title":"Accelerating the offshore CCUS to carbon-neutral China","authors":"Jianghui Li","doi":"10.1016/j.fmre.2022.10.015","DOIUrl":"10.1016/j.fmre.2022.10.015","url":null,"abstract":"<div><div>Offshore carbon capture, utilization, and storage (CCUS) is to capture CO<span><math><msub><mrow></mrow><mn>2</mn></msub></math></span> from emission sources and then inject the captured CO<span><math><msub><mrow></mrow><mn>2</mn></msub></math></span> into sub-seabed geological reservoirs, thus it will be permanently isolated from the atmosphere. CCUS was therefore proposed as a technological decarbonization strategy to prevent millions of tonnes of anthropogenic CO<span><math><msub><mrow></mrow><mn>2</mn></msub></math></span> from entering and remaining in the atmosphere. In this review, the necessity and suitability of offshore CCUS in China are explored, involving examining the potential for sedimentary basins offshore China to act as carbon sinks for industrialized coastal regions and investigating the opportunities of developing a commercial full value chain. In China, the CO<span><math><msub><mrow></mrow><mn>2</mn></msub></math></span> emissions from the 14 coastal provincial administrative regions are estimated to be over 4.2 Gt, occupying <span><math><mo>∼</mo></math></span>41% of the country’s carbon emissions, whereas the storage capacity of the sedimentary basins offshore China is estimated to be 573–779 GtCO<span><math><msub><mrow></mrow><mn>2</mn></msub></math></span>. This could total 140–190 years of emissions from China’s coastal regions, which also avoids complex legal regulation and public opposition. However, economic costs pose substantial challenges to deploying offshore CCUS on a commercial scale, which requires significant technological innovations, national contributions, and business investments, particularly in the eastern and southeastern regions.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 2","pages":"Pages 715-726"},"PeriodicalIF":6.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isotopic evidence reveals the gradual intensification of millet agriculture in Neolithic western Loess Plateau 同位素证据揭示黄土高原西部新石器时代谷子农业的逐渐强化

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-03-01 DOI: 10.1016/j.fmre.2023.06.007

Minmin Ma , Jiajia Dong , Yishi Yang , Martin K. Jones , Jia Wang , Guoke Chen , Gang Li , Letian He , Wenyu Wei , Yongxiang Xu , Yongxiu Lu , Lele Ren , Guanghui Dong , Fahu Chen

{"title":"Isotopic evidence reveals the gradual intensification of millet agriculture in Neolithic western Loess Plateau","authors":"Minmin Ma , Jiajia Dong , Yishi Yang , Martin K. Jones , Jia Wang , Guoke Chen , Gang Li , Letian He , Wenyu Wei , Yongxiang Xu , Yongxiu Lu , Lele Ren , Guanghui Dong , Fahu Chen","doi":"10.1016/j.fmre.2023.06.007","DOIUrl":"10.1016/j.fmre.2023.06.007","url":null,"abstract":"<div><div>The intensification of millet agriculture facilitated the development of ancient civilization in northern China. In Inner Mongolia and the Central Plains, the intensification of millet farming was relatively continuous. However, prior evidence from the western Loess Plateau (WLP) has suggested an indistinct sequence of millet cultivation and a time lag between the initial intensification of millet agriculture and subsequent expansion of millet farming. We report on new stable isotopic data and radiocarbon dates from the Gedachuan site which challenge that interpretation. Our results indicate a gradual intensification and expansion of millet agriculture across the whole WLP. They attest to intensive broomcorn millet-based farming underpinning the emergence and development of the agrarian society in the WLP during the early-middle Yangshao period (∼6300–5500 BP), and to an intensification of the higher-yielding foxtail millet–based farming leading to the rapid growth of population in the WLP and expansion of millet cultivation after 5300 BP.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 2","pages":"Pages 727-733"},"PeriodicalIF":6.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42971056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graph contrastive learning with node-level accurate difference

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-03-01 DOI: 10.1016/j.fmre.2024.06.013

Pengfei Jiao , Kaiyan Yu , Qing Bao , Ying Jiang , Xuan Guo , Zhidong Zhao

{"title":"Graph contrastive learning with node-level accurate difference","authors":"Pengfei Jiao , Kaiyan Yu , Qing Bao , Ying Jiang , Xuan Guo , Zhidong Zhao","doi":"10.1016/j.fmre.2024.06.013","DOIUrl":"10.1016/j.fmre.2024.06.013","url":null,"abstract":"<div><div>Graph contrastive learning (GCL) has attracted extensive research interest due to its powerful ability to capture latent structural and semantic information of graphs in a self-supervised manner. Existing GCL methods commonly adopt predefined graph augmentations to generate two contrastive views. Subsequently, they design a contrastive pretext task between these views with the goal of maximizing their agreement. These methods assume the augmented graph can fully preserve the semantics of the original. However, typical data augmentation strategies in GCL, such as random edge dropping, may alter the properties of the original graph. As a result, previous GCL methods overlooked graph differences, potentially leading to difficulty distinguishing between graphs that are structurally similar but semantically different. Therefore, we argue that it is necessary to design a method that can quantify the dissimilarity between the original and augmented graphs to more accurately capture the relationships between samples. In this work, we propose a novel graph contrastive learning framework, named Accurate Difference-based Node-Level Graph Contrastive Learning (DNGCL), which helps the model distinguish similar graphs with slight differences by learning node-level differences between graphs. Specifically, we train the model to distinguish between original and augmented nodes via a node discriminator and employ cosine dissimilarity to accurately measure the difference between each node. Furthermore, we employ multiple types of data augmentation commonly used in current GCL methods on the original graph, aiming to learn the differences between nodes under different augmentation strategies and help the model learn richer local information. We conduct extensive experiments on six benchmark datasets and the results show that our DNGCL outperforms most state-of-the-art baselines, which strongly validates the effectiveness of our model.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 2","pages":"Pages 818-829"},"PeriodicalIF":6.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A recent survey on instance-dependent positive and unlabeled learning 基于实例的积极无标签学习研究进展

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-03-01 DOI: 10.1016/j.fmre.2022.09.019

Chen Gong , Muhammad Imran Zulfiqar , Chuang Zhang , Shahid Mahmood , Jian Yang

{"title":"A recent survey on instance-dependent positive and unlabeled learning","authors":"Chen Gong , Muhammad Imran Zulfiqar , Chuang Zhang , Shahid Mahmood , Jian Yang","doi":"10.1016/j.fmre.2022.09.019","DOIUrl":"10.1016/j.fmre.2022.09.019","url":null,"abstract":"<div><div>Training with confident positive-labeled instances has received a lot of attention in Positive and Unlabeled (PU) learning tasks, and this is formally termed “Instance-Dependent PU learning”. In instance-dependent PU learning, whether a positive instance is labeled depends on its labeling confidence. In other words, it is assumed that not all positive instances have the same probability to be included by the positive set. Instead, the instances that are far from the potential decision boundary are with larger probability to be labeled than those that are close to the decision boundary. This setting has practical importance in many real-world applications such as medical diagnosis, outlier detection, object detection, etc. In this survey, we first present the preliminary knowledge of PU learning, and then review the representative instance-dependent PU learning settings and methods. After that, we thoroughly compare them with typical PU learning methods on various benchmark datasets and analyze their performances. Finally, we discuss the potential directions for future research.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 2","pages":"Pages 796-803"},"PeriodicalIF":6.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46910242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0