Fundamental Research最新文献_第3页

Capture and identification of the electrogenerated picosecond intermediates by mass spectrometry 用质谱法捕获和鉴定电生皮秒中间体

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-03-01 Epub Date: 2023-12-16 DOI: 10.1016/j.fmre.2023.08.016

Ting Wang , Qiuyue Cheng , Jun Hu , Hongyuan Chen , Jingjuan Xu

{"title":"Capture and identification of the electrogenerated picosecond intermediates by mass spectrometry","authors":"Ting Wang , Qiuyue Cheng , Jun Hu , Hongyuan Chen , Jingjuan Xu","doi":"10.1016/j.fmre.2023.08.016","DOIUrl":"10.1016/j.fmre.2023.08.016","url":null,"abstract":"<div><div>Probing and identification of the reactive intermediates in electrochemical transformations is essential for gaining in-depth insights into their reaction mechanisms. However, due to their extremely short lifetimes, characterizing the electrogenerated transient species remains a significant challenge for currently available techniques. In this work, we report the first mass spectrometric identification of the electrogenerated transient nitrenium ions (R<sub>2</sub>N<sup>+</sup>) and oxenium ions (R–O<sup>+</sup>), whose lifetimes in solutions are as short as picoseconds. This achievement is made possible by the fabrication of a dual-function hybrid ultramicroelectrode/ion emitter, which permits the <em>in-situ</em> generation and rapid transferring of the fleeting intermediates into the gas phase for mass spectrometric analysis. For the first time, a series of previously hypothetical nitrenium/oxenium ions, including the long-sought glycosyl cations, were directly probed using mass spectrometry. Additionally, we also propose a viable mechanism involving the stabilizing effects of the positively charged microdroplets to explain the capture of the transient intermediates.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 810-815"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138986431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Designing precision measurement of the gravitational Aharonov-Bohm effect in microgravity 设计微重力条件下引力Aharonov-Bohm效应的精密测量方法

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-03-01 Epub Date: 2024-05-25 DOI: 10.1016/j.fmre.2024.05.006

Yuan Sun , Liang Liu

{"title":"Designing precision measurement of the gravitational Aharonov-Bohm effect in microgravity","authors":"Yuan Sun , Liang Liu","doi":"10.1016/j.fmre.2024.05.006","DOIUrl":"10.1016/j.fmre.2024.05.006","url":null,"abstract":"<div><div>The gravitational Aharonov-Bohm (GAB) effect serves as the gravitational counterpart to the electromagnetic Aharonov-Bohm effect. Despite the concept’s inception in 1967, a rigorous experimental test of the GAB effect remains elusive. While recent endeavors with ground-based apparatus show promise in uncovering hints of the GAB effect, we propose a precise yet practical experiment to deterministically measure the GAB phase shift using cold atom interferometry in a microgravity environment, such as an orbital space station or drop tower. We conduct a thorough analysis of the experiment’s principles and derive key parameters. Our calculations suggest that it is feasible to precisely measure a significant GAB phase shift within known engineering constraints. Additionally, our design of the cold atom interferometer possesses a unique sensitivity to potential but insensitivity to force, which can be further refined to effectively mitigate adverse effects associated with nonzero inertial forces acting on the cold atoms. These endeavors will ultimately pave the way for experimental exploration into the quantum nature of gravity.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 713-717"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147620742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple Brillouin zone folding based broadband topological slow light in valley photonic crystals 谷光子晶体中基于多布里渊带折叠的宽带拓扑慢光

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-03-01 Epub Date: 2025-10-01 DOI: 10.1016/j.fmre.2025.09.019

Min Zhang , Tianji Liu , Wei Li

{"title":"Multiple Brillouin zone folding based broadband topological slow light in valley photonic crystals","authors":"Min Zhang , Tianji Liu , Wei Li","doi":"10.1016/j.fmre.2025.09.019","DOIUrl":"10.1016/j.fmre.2025.09.019","url":null,"abstract":"<div><div>Topological photonic crystals (TPCs) have attracted considerable attention in integrated photonics community for the intriguing prospect of robust light transport. As a photonic analogue of quantum valley Hall insulators, valley photonic crystals (VPCs) support topologically protected directional edge modes without broken time-reversal symmetry. However, the observation of VPCs-based broadband slow light remains challenging due to the frequency discontinuity of valley kink modes resulting from the broken symmetry at the domain wall. In this work, we achieve continuous broadband topological slow light in two-dimensional VPCs. Based on the coupling of size-perturbed resonator periodic array, the resulting kink mode has been dramatically slow down through multiple Brillouin zone folding and separated with mini-gaps. To circumvent the mini-gaps issue, we propose a continuous broadband topological slow light waveguide consisting of two combined and frequency complementary VPCs waveguides. We also obtain a novel topological frequency-selective beam splitter based on the valley-contrasting directional slow-light propagation. Our results provide exciting opportunities in topological slow-light applications.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 733-739"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147620745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refinement of selective hydrogenation catalysts guided by the concept of ‘group recognition’ 基于“基团识别”概念的选择性加氢催化剂的改进

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-03-01 Epub Date: 2024-09-06 DOI: 10.1016/j.fmre.2024.09.002

Bing Lu , Shanjun Mao , Zhe Wang , Yong Wang

{"title":"Refinement of selective hydrogenation catalysts guided by the concept of ‘group recognition’","authors":"Bing Lu , Shanjun Mao , Zhe Wang , Yong Wang","doi":"10.1016/j.fmre.2024.09.002","DOIUrl":"10.1016/j.fmre.2024.09.002","url":null,"abstract":"<div><div>Selective hydrogenation is crucial in the production of high-value chemicals, yet its efficient implementation remains challenging due to the absence of clear catalyst regulation strategies and in-depth insights into catalytic mechanisms. This paper discusses several feasible solutions for achieving efficient selective hydrogenation by adjusting the fine structure of catalysts drawing from our successful examples in recent work. Building upon a deep understanding of the fundamental principles of heterogeneous catalysis, structure-performance relations, and insights gleaned from our previous achievements, we identify 'group recognition' as the central mechanism for achieving efficient selective hydrogenation. Our catalyst design strategies revolve around three key aspects: adjusting geometric structure, controlling electronic structure, and regulating the local domain of active sites. Furthermore, we present the latest advancements in decoupling the geometric and electronic effects, addressing the longstanding challenge of disentangling these intertwined factors. It is our conviction that this paper offers valuable experience and innovative ideas for realizing efficient selective hydrogenation.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 745-749"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147620746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting fatty acid metabolism for cancer therapy 针对脂肪酸代谢的癌症治疗

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-03-01 Epub Date: 2024-09-28 DOI: 10.1016/j.fmre.2024.09.011

Lu Zhang , Yuwen Yao , Suling Liu

引用次数: 0

Multiscale modeling and simulation for anomalous and nonergodic dynamics: From statistics to mathematics 异常和非遍历动力学的多尺度建模和模拟：从统计学到数学

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-03-01 Epub Date: 2025-01-11 DOI: 10.1016/j.fmre.2024.12.024

Heng Wang , Xuhao Li , Lijing Zhao , Weihua Deng

{"title":"Multiscale modeling and simulation for anomalous and nonergodic dynamics: From statistics to mathematics","authors":"Heng Wang , Xuhao Li , Lijing Zhao , Weihua Deng","doi":"10.1016/j.fmre.2024.12.024","DOIUrl":"10.1016/j.fmre.2024.12.024","url":null,"abstract":"<div><div>In recent decades, anomalous and nonergodic diffusions are topical issues in almost all disciplines. In 2004, the phrase “anomalous is normal” was used in a title of a Physical Review Letters (PRL) paper, which reveals that the diffusion of classical particles on a solid surface has rich anomalous behavior controlled by the friction coefficient, meaning that anomalous diffusion phenomena are ubiquitous in the natural world. This review article first builds the microscopic models (stochastic processes) to describe the experimentally observed phenomena of the motion of the physical/abstract particles under the frameworks of continuous time random walks, Langevin picture, subordinated strong Markov process, etc. Beyond directly conducting statistical analyses on these stochastic processes, we target on delving into these microscopic models to uncover their physical mechanisms and digging out their potential applications. According to the application scenarios and the research requirements, we design the appropriate statistical observables, e.g., the position of the particles, functional of the trajectories of the particles, probability of the first passage time, escape probability, etc. Then, we derive the governing equations of the probability density functions of the statistical observables. We do the mathematical studies on the equations, including well-posedness and regularity analyses, designing numerical schemes, performing numerical analyses, etc. Finally, we present the applications of the models in chemistry and biology, and propose future prospects in this research field.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 659-671"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147620890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphology of glandular trichome and lignin-based structure for its function 腺体毛状体的形态及其功能的木质素基结构

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-03-01 Epub Date: 2025-02-28 DOI: 10.1016/j.fmre.2025.02.014

Ning Hao , Takehiro Kamiya , Tao Wu

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Cooperative driving of mixed autonomy vehicles: A delay-compensating MPC approach 混合自动驾驶车辆协同驾驶：一种延迟补偿MPC方法

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-03-01 Epub Date: 2025-01-31 DOI: 10.1016/j.fmre.2023.12.025

Xuan Wang , Yougang Bian , Mangjiang Hu , Hongmao Qin , Rongjun Ding

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The separation and compactness on fuzzy partial metric spaces 模糊偏度量空间上的分离性与紧性

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-03-01 Epub Date: 2025-03-05 DOI: 10.1016/j.fmre.2025.02.003

Han Wang , Chong Shen , Zhenyu Jin

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Rational engineering of cholesterol-modified prodrug nanoassemblies for improving the tumor selectivity and safety of mitoxantrone 合理设计胆固醇修饰的前药纳米组件以提高米托蒽醌的肿瘤选择性和安全性

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-03-01 Epub Date: 2024-06-28 DOI: 10.1016/j.fmre.2024.06.006

Bowen Zhang , Wenyuan Liu , Jinrui Liu , Minglong Huang , Yaqiao Li , Erwei Zhao , Lurong Zhang , Xianbao Shi , Jin Sun , Zhonggui He , Lingxiao Li , Bingjun Sun

{"title":"Rational engineering of cholesterol-modified prodrug nanoassemblies for improving the tumor selectivity and safety of mitoxantrone","authors":"Bowen Zhang , Wenyuan Liu , Jinrui Liu , Minglong Huang , Yaqiao Li , Erwei Zhao , Lurong Zhang , Xianbao Shi , Jin Sun , Zhonggui He , Lingxiao Li , Bingjun Sun","doi":"10.1016/j.fmre.2024.06.006","DOIUrl":"10.1016/j.fmre.2024.06.006","url":null,"abstract":"<div><div>Mitoxantrone (MTO) is an anthraquinone antitumor drug with potent therapeutic benefits. However, its clinical application is restricted by the severe side effects stemming from poor tumor selectivity. In this study, MTO and cholesterol (CLS) were conjugated via a tumor-selective disulfide bond to obtain the MTO-SS-CLS prodrug. Interestingly, the MTO-SS-CLS could self-assemble into uniform nanoassemblies, and the addition of DSPE-PEG<sub>2K</sub> significantly improved its self-assembly behavior and stability. Moreover, compared with MTO solutions, the disulfide bond-bridged MTO-SS-CLS nanoassemblies exhibited heightened tumor selectivity and pharmacokinetic properties. In addition, the prodrug nanoassemblies improved the tolerated dose and safety of MTO without compromising its therapeutic effect. This research enriches the pharmaceutical research of MTO and paves the way for its extensive clinical application.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 1041-1049"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147620880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0