用于骨组织工程的可编程dna生物材料

IF 6.2 3区综合性期刊 Q1 Multidisciplinary

Fundamental Research Pub Date : 2025-07-01 DOI:10.1016/j.fmre.2024.12.015

Xiaoyue Xu , Erfeng Kou , Honglu Zhang , Kunyu Zhang , Huan Zhang

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引用次数: 0

摘要

骨缺损是骨组织疾病的常见病理，现有的治疗干预措施有明显的局限性，突出了对创新策略和先进生物材料的需求。DNA，传统上被认为是一种重要的遗传物质，也具有作为生物材料的特殊特性，使其成为制造各种基于DNA的生物材料（如DNA框架材料和DNA水凝胶）的理想纳米级构建块。基于dna的生物材料具有显著的优势，包括结构的通用性、生物相容性，以及至关重要的可编程性，这使它们成为骨组织工程的有希望的候选者。本文综述了近年来基于dna的生物材料在仿生矿化和给药系统中的应用进展，以及它们在该领域的应用前景。

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Programmable DNA-based biomaterials for bone tissue engineering

Bone defects are a common pathology in bone tissue diseases, and existing therapeutic interventions have significant limitations, highlighting the need for innovative strategies and advanced biomaterials. DNA, traditionally recognized as a prominent genetic material, also possesses exceptional properties as a biological material, making it an ideal nanoscale building block for creating various DNA-based biomaterials, such as DNA framework materials and DNA hydrogels. DNA-based biomaterials offer notable advantages, including structural versatility, biocompatibility, and, crucially, programmability, which position them as promising candidates for bone tissue engineering. This review explores recent advancements in the use of DNA-based biomaterials for bionic mineralization and drug delivery systems, as well as their future potential in this field.

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