Fundamental Research最新文献_第7页

Create more and more triboelectric charges on polymer surface 在聚合物表面产生越来越多的三电荷

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-07-01 DOI: 10.1016/j.fmre.2024.01.009

Xinglin Tao , Xiangyu Chen

引用次数: 0

Nighttime traffic object detection via adaptively integrating event and frame domains 基于自适应整合事件域和框架域的夜间交通目标检测

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-07-01 DOI: 10.1016/j.fmre.2023.08.004

Yu Jiang , Yuehang Wang , Minghao Zhao , Yongji Zhang , Hong Qi

{"title":"Nighttime traffic object detection via adaptively integrating event and frame domains","authors":"Yu Jiang , Yuehang Wang , Minghao Zhao , Yongji Zhang , Hong Qi","doi":"10.1016/j.fmre.2023.08.004","DOIUrl":"10.1016/j.fmre.2023.08.004","url":null,"abstract":"<div><div>Intelligent perception is crucial in Intelligent Transportation Systems (ITS), with vision cameras as critical components. However, traditional RGB cameras exhibit a significant decline in performance when capturing nighttime traffic scenes, limiting their effectiveness in supporting ITS. In contrast, event cameras possess a high dynamic range (140 dB vs. 60 dB for traditional cameras), enabling them to overcome frame degradation in low-light conditions. Recently, multimodal learning paradigms have made substantial progress in various vision tasks, such as image-text retrieval. Motivated by this progress, we propose an adaptive selection and fusion detection method that leverages both event and RGB frame domains to optimize nighttime traffic object detection jointly. To address the challenge of unbalanced multimodal data fusion, we design a learnable adaptive selection and fusion module. This module performs feature ranking and fusion in the channel dimension, allowing efficient multimodal fusion. Additionally, we construct a novel multi-level feature pyramid network based on multimodal attention fusion. This network extracts potential features to enhance robustness in detecting nighttime traffic objects. Furthermore, we curate a dataset for nighttime traffic scenarios comprising RGB frames and corresponding event streams. Through experiments, we demonstrate that our proposed method outperforms current state-of-the-art techniques in event-based, frame-based, and event and frame fusion methods. This highlights the effectiveness of integrating the event and frame domains in enhancing nighttime traffic object detection.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 4","pages":"Pages 1633-1644"},"PeriodicalIF":6.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135654954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The PODNL1/AKT/β-catenin signaling axis mediates glioma progression and sensitivity to temozolomide PODNL1/AKT/β-catenin信号轴介导胶质瘤进展和对替莫唑胺的敏感性

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-07-01 DOI: 10.1016/j.fmre.2023.03.005

Shanqiang Qu , Chengying Huang , Zhicheng Hu

{"title":"The PODNL1/AKT/β-catenin signaling axis mediates glioma progression and sensitivity to temozolomide","authors":"Shanqiang Qu , Chengying Huang , Zhicheng Hu","doi":"10.1016/j.fmre.2023.03.005","DOIUrl":"10.1016/j.fmre.2023.03.005","url":null,"abstract":"<div><div>Abnormal expression of small leucine-rich repeat proteins (SLRP) in tumor tissues has been reported as a critical trigger for tumorigenesis and progression. However, the molecular mechanism of PODNL1, a novel member of SLRP family, in glioma remains largely unknown. Therefore, this study aimed to investigate its correlation with clinical factors by glioma cohort and to identify the molecular mechanisms of aberrant PODNL1 gene expression in glioma. Our findings revealed that both PODNL1 mRNA and protein levels were markedly upregulated in glioma tissues, and high PODNL1 mRNA level was significantly associated with poor prognosis of glioma patients. In functional assays, PODNL1 knockdown significantly suppressed the proliferation and invasion abilities of glioma cells, while overexpression of PODNL1 had the opposite effect both <em>in vitro</em> and <em>in vivo</em>. Mechanistically, PODNL1 knockdown suppressed the activation of AKT/mTOR signaling and inhibited nuclear translocation of β-catenin protein in the glioma cells. Our results suggest that PODNL1 acts as an oncogenic factor in glioma by promoting glioma progression through the activation of the kinase AKT, which indeces β-catenin nuclear translocation. Additionally, PODNL1 knockdown enhanced the sensitivity of glioma cells to temozolomide, a chemotherapeutic agent commonly used in the treatment of glioma. The PODNL1/AKT/β-catenin signaling axis represents a new potential therapeutic target against glioma. Furthermore, our data showed the combination of temozolomide and MK-2206, an AKT inhibitor, had a synergistic antitumor effect against glioma cells.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 4","pages":"Pages 1822-1830"},"PeriodicalIF":6.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45298347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling and analysis of vehicle path dispersion at signalized intersections using explainable backpropagation neural networks 基于可解释反向传播神经网络的信号交叉口车辆路径离散建模与分析

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-07-01 DOI: 10.1016/j.fmre.2023.08.008

Jing Zhao , Ruoming Ma , Jian Sun , Rongji Zhang , Cheng Zhang

{"title":"Modeling and analysis of vehicle path dispersion at signalized intersections using explainable backpropagation neural networks","authors":"Jing Zhao , Ruoming Ma , Jian Sun , Rongji Zhang , Cheng Zhang","doi":"10.1016/j.fmre.2023.08.008","DOIUrl":"10.1016/j.fmre.2023.08.008","url":null,"abstract":"<div><div>The dispersion of vehicular paths is a common phenomenon in the inner area of signalized intersections due to heterogeneous driver behavior and interactions. This study aims to develop an explainable neural network-based model to describe the vehicle path dispersion by exploring the relationship between the path dispersion and external factors. A backpropagation neural network model was established to analyze the effects of external factors on the dispersion of through and left-turn paths based on real trajectory data collected from 20 intersections in Shanghai, China. Twelve influencing factors in varying geometric, traffic, signalization, and traffic management conditions were considered. The predictive power and transferability of the model were verified by applying the trained model on the four new intersections. The contributions of the influencing factors on the path dispersion were explored based on the neural interpretation diagram, relative importance of influencing factors, and sensitivity analysis to offer explanatory insights for the proposed model. The results show that the mean absolute percentage errors of the path dispersion models for the through and left-turn movements are only 14.67% and 17.65%, respectively. The through path dispersion is primarily influenced by the number of exit lanes, the offset degree between the approach and exit lanes, and the traffic saturation degree on the through lane. In contrast, the path dispersion of the left turn is mainly affected by the number of exit lanes, the left-turn angle, and the setting of guide lines.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 4","pages":"Pages 1645-1658"},"PeriodicalIF":6.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135455856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A special machine for solving NP-complete problems 求解np完全问题的专用机器

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-07-01 DOI: 10.1016/j.fmre.2025.05.010

Jin Xu , Le Yu , Huihui Yang , Siyuan Ji , Pu Wu , Yu Zhang , Anqi Yang , Quanyou Li , Haisheng Li , Enqiang Zhu , Xiaolong Shi , Zehui Shao , Huang Leng , Xiaoqing Liu

{"title":"A special machine for solving NP-complete problems","authors":"Jin Xu , Le Yu , Huihui Yang , Siyuan Ji , Pu Wu , Yu Zhang , Anqi Yang , Quanyou Li , Haisheng Li , Enqiang Zhu , Xiaolong Shi , Zehui Shao , Huang Leng , Xiaoqing Liu","doi":"10.1016/j.fmre.2025.05.010","DOIUrl":"10.1016/j.fmre.2025.05.010","url":null,"abstract":"<div><div>A specialized computer named as the Electronic Probe Computer (EPC) has been developed to address large-scale NP-complete problems. The EPC employs a hybrid serial/parallel computational model, structured around four main subsystems: a converting system, an input/output system, and an operating system. The converting system is a software component that transforms the target problem into the graph coloring problem, while the operating system is designed to solve these graph coloring challenges. Comprised of 60 probe computing cards, this system is referred to as EPC60. In tackling large-scale graph coloring problems with EPC60, 100 3-colorable graphs were randomly selected, each consisting of 2,000 vertices. The state-of-the-art mathematical optimization solver achieved a success rate of only 6%, while EPC60 excelled with a remarkable 100% success rate. Additionally, EPC60 successfully solved two 3-colorable graphs with 1,500 and 2,000 vertices, which had eluded Gurobi’s attempts for 15 days on a standard workstation. Given the mutual reducibility of NP-complete problems in polynomial time theoretically, the EPC stands out as a universal solver for NP-complete problem. The EPC can be applied to various problems that can be abstracted as combinatorial optimization issues, making it relevant across multiple domains, including supply chain management, financial services, telecommunications, energy systems, manufacturing, and beyond.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 4","pages":"Pages 1743-1749"},"PeriodicalIF":6.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promoting oxygen reduction reaction by tuning externally doped nitrogen around atomically dispersed iron 通过调节原子分散铁周围的外掺杂氮来促进氧还原反应

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-07-01 DOI: 10.1016/j.fmre.2022.07.014

Ning Sun , Sen Ru , Chao Zhang , Wei Liu , Qiquan Luo , Jiqing Jiao , Tongbu Lu

{"title":"Promoting oxygen reduction reaction by tuning externally doped nitrogen around atomically dispersed iron","authors":"Ning Sun , Sen Ru , Chao Zhang , Wei Liu , Qiquan Luo , Jiqing Jiao , Tongbu Lu","doi":"10.1016/j.fmre.2022.07.014","DOIUrl":"10.1016/j.fmre.2022.07.014","url":null,"abstract":"<div><div>As potential alternatives to Pt-based catalysts for oxygen reduction reaction (ORR), iron (Fe)-based single-atomic site catalysts (SACs) have shown superior performances compared with others. For Fe SACs, the effect of directly coordinating N atoms has received intensive discussion, yet by contrast, the effect of secondary coordinating atoms has been left largely unexplored. Here, we developed a route to tuning externally doped N around Fe SACs to boost ORR activity. Density functional theory (DFT) calculations established the four different models for FeN<sub>4</sub> for ORR, indicating that the FeN<sub>4</sub>-PR-GN (pyrrolic-N for the first coordination shell and graphitic-N for the second coordination shell) can effectively improve the ORR performance. On the basis of theoretical calculations, we developed a two-step strategy including interior encapsulation and surface adsorption, which helped to regulate the different external coordination N of Fe SACs. The best-performing catalyst, FeN<sub>4</sub>-PR-GN, displays excellent ORR performances in alkaline electrolytes; in particular, the catalyst gives a half-wave potential of 0.92 V (<em>vs.</em> RHE) and high stability, which is much better than those of commercial Pt/C. Our work here not only demonstrates an efficient catalyst to boost ORR performances, but also develops a facile strategy for the preparation of SACs for advanced fuel cells.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 4","pages":"Pages 1488-1494"},"PeriodicalIF":6.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44999940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel energy utilization mechanisms of microorganisms in the hydrosphere 水圈微生物的新型能量利用机制

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-07-01 DOI: 10.1016/j.fmre.2023.12.014

Anhuai Lu , Jia Liu , Meiying Xu , Shungui Zhou , Juan Liu , Fanghua Liu , Yong Nie , Hongrui Ding , Yan Li

{"title":"Novel energy utilization mechanisms of microorganisms in the hydrosphere","authors":"Anhuai Lu , Jia Liu , Meiying Xu , Shungui Zhou , Juan Liu , Fanghua Liu , Yong Nie , Hongrui Ding , Yan Li","doi":"10.1016/j.fmre.2023.12.014","DOIUrl":"10.1016/j.fmre.2023.12.014","url":null,"abstract":"<div><div>This review focuses on new approaches adopted by microorganisms to acquire energy in oligotrophic and low-energy hydrosphere habitats, which involves increasing income, reducing expenditure and cooperation among different microorganisms. The various energy sources, electron transfer pathways and carbon, nitrogen, and sulfur cycles are involved in these processes. Specifically, this review delves into the potential molecular mechanisms on microbes utilizing photoelectrons from semiconducting minerals in natural photocatalytic systems. Also, it aims to reveal the regulation mechanisms of photoelectrons on interspecific electron transfer pathways and the energy synthesis processes in <em>Geobacter, Pseudomonas, Halomonas</em> and sulfate reducing bacteria, as well as the molecular mechanisms of perception and adaptation to different potentials of extracellular receptors and changes of oxygen gradients. Moreover, it demonstrates the network structure, formation and mechanisms of long-distance electron transfer driven by cable bacteria, particularly in the context of reducing CH<sub>4</sub> and N<sub>2</sub>O coupled with the increase of dimethyl sulfide. This paper attempts to put forward new ideas for the energy utilization by microorganisms and their impact on element cycle in the hydrosphere, which contributes to a better understanding of the energy metabolism in interspecific, interspecies, and ecosystem contexts during the cycle-coupled processes of elements.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 4","pages":"Pages 1584-1596"},"PeriodicalIF":6.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139890021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carrier-free delivery of nucleic acid and photosensitizer nanoparticles for enhanced photodynamic and gene antitumour therapy 无载体输送核酸和光敏剂纳米粒子，用于增强光动力和基因抗肿瘤疗法

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-07-01 DOI: 10.1016/j.fmre.2024.03.014

Ningyu Li , Fan Dong , Lisha Sun , Yuping Qian , Ludan Zhang , Guiyan Wang , Lintian Yuan , Hong Liu , Yong Jiang , Yuguang Wang

{"title":"Carrier-free delivery of nucleic acid and photosensitizer nanoparticles for enhanced photodynamic and gene antitumour therapy","authors":"Ningyu Li , Fan Dong , Lisha Sun , Yuping Qian , Ludan Zhang , Guiyan Wang , Lintian Yuan , Hong Liu , Yong Jiang , Yuguang Wang","doi":"10.1016/j.fmre.2024.03.014","DOIUrl":"10.1016/j.fmre.2024.03.014","url":null,"abstract":"<div><div>Activated anti-oxidation reactions in cells partially diminish the anticancer effect of photodynamic therapy (PDT), significantly hindering efforts to increase the efficacy of PDT. The expression of transcription factor E2 related factor 2 (Nrf2), an important redox-regulated transcription factor, can be downregulated by Nrf2 siRNA, leading to greatly enhanced PDT effects. However, the efficient co-delivery of photosensitizers and siRNAs remains a key problem because these agents are complex to synthesize, exhibit poor biocompatibility and load drugs with a low efficiency. Herein, we designed a carrier–free and extremely simple strategy to co-deliver a photosensitizer and Nrf2 siRNA to cancer cells. In this nanoplatform, an indocyanine green photosensitizer, siRNA and FeⅡ were self-assembled to form a spherical hybrid structure with a uniform size, high loading ratio and adjustable component ratio. The platform can effectively transfer photosensitizers and siRNAs into cells and effectively inhibit tumour growth <em>in vivo</em>. Overall, the self-assembly approach shows great potential for clinical application and provides a simple method to achieve photodynamic therapy and enhanced photothermal therapy.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 4","pages":"Pages 1698-1709"},"PeriodicalIF":6.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140403804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seahorse‐exoskeleton‐inspired structure with linear‐to‐torsion transition property for low-frequency vibration isolation 海马外骨骼启发结构，具有线性到扭转过渡特性，用于低频隔振

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-07-01 DOI: 10.1016/j.fmre.2025.02.002

Bo Yan , Shangwen Wang , Peng Ling , Zhibo Yang , Hongye Ma , Qinchuan Li

{"title":"Seahorse‐exoskeleton‐inspired structure with linear‐to‐torsion transition property for low-frequency vibration isolation","authors":"Bo Yan , Shangwen Wang , Peng Ling , Zhibo Yang , Hongye Ma , Qinchuan Li","doi":"10.1016/j.fmre.2025.02.002","DOIUrl":"10.1016/j.fmre.2025.02.002","url":null,"abstract":"<div><div>The square exoskeleton of seahorses can transit linear motion into torsion to dissipate energy and protect the vertebrate when subjected to external disturbances. Inspired by the self-protection mechanism of the linear-to-torsion transition of the square exoskeleton of seahorses, a novel seahorse-exoskeleton-inspired structure (SES) is designed, which consists of two oblique rods and springs, and a rotational disc. The geometric relationship and dynamic model are established to reveal the corresponding nonlinear stiffness, adjustable high carrying capacity and large working range characteristics. The dynamic equation of the SES is derived according to the Lagrange equation and the frequency response relationship is obtained with the harmonic balance method. Then the effects of structural parameters on the nonlinear restoring force, nonlinear inertia, nonlinear quadratic force, nonlinear damping and the vibration isolation performance are studied comprehensively to achieve the low-frequency isolation characteristics. A SES prototype was manufactured and the corresponding experiment was carried out to verify the low-frequency vibration isolation performance of SES. The tested peak frequency of the unloaded SES can be lower to 1.48 Hz due to the linear-to-torsion property, which can generate torsional inertia and anti-resonance phenomenon. Furthermore, the nonlinear damping is positively correlated with input displacement. SES has a better vibration isolation performance under large excitation amplitude. This paper provides a guideline for the design of low-frequency bio-inspired vibration isolators with the linear-to-torsion transition mechanism.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 4","pages":"Pages 1505-1523"},"PeriodicalIF":6.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PIAS4 regulates pluripotency exit and cell fate commitment in porcine embryonic stem cells PIAS4调控猪胚胎干细胞多能性退出和细胞命运承诺

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-07-01 DOI: 10.1016/j.fmre.2024.10.016

Wei Qin , Yu Wang , Hongfei Duan , Qiao Li , Dagang Tao , Peng Su , Linhui Wu , Delong Li , Tian Xu , Shengsong Xie , Xia Zhang , Jilong Zhou , Yi-Liang Miao

{"title":"PIAS4 regulates pluripotency exit and cell fate commitment in porcine embryonic stem cells","authors":"Wei Qin , Yu Wang , Hongfei Duan , Qiao Li , Dagang Tao , Peng Su , Linhui Wu , Delong Li , Tian Xu , Shengsong Xie , Xia Zhang , Jilong Zhou , Yi-Liang Miao","doi":"10.1016/j.fmre.2024.10.016","DOIUrl":"10.1016/j.fmre.2024.10.016","url":null,"abstract":"<div><div>Post-translational modifications (PTMs) are dynamic processes that regulate cell states by enhancing proteome diversity. However, the overall impact of PTMs on pluripotency exit in porcine embryonic stem cells (pESCs) remains largely unknown. Here, we present a systematic assay to identify E3 ubiquitin ligases for pluripotency exit by using CRISPR/Cas9 pooled screening and identified PIAS4 as a major regulator of pluripotency exit, as the cell differentiation was significantly impaired upon PIAS4 depletion in pESCs. PIAS4 shows a high degree of genomic occupation in promoter regions, particularly in key pluripotency maintenance genes. Moreover, we found that PIAS4 was recruited to the gene promoter marked by H3K4me3 and interacted with lysine demethylase KDM5B via SUMOylation, thereby affecting the stability of KDM5B and further facilitating the regulation of H3K4me3-mediated lineage-specific genes. Together, our findings reveal a regulatory mechanism by which PIAS4 modulates H3K4me3 modification on development-related genes, subsequently influencing pluripotency exit and cell fate commitment by interacting with KDM5B in pESCs.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 4","pages":"Pages 1556-1569"},"PeriodicalIF":6.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0