Fundamental Research最新文献_第7页

Loosening metal nodes in metal-organic frameworks to facilitate the regulation of valence 松开金属有机框架中的金属节点以促进价态的调节

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-01-01 DOI: 10.1016/j.fmre.2022.08.012

Yu-Xia Li, Jia-Xin Shen, Ze-Jiu Diao, Shi-Chao Qi, Xiao-Qin Liu, Lin-Bing Sun

引用次数: 0

Adsorbate-driven dynamic active sites in stannosilicate zeolites 锡硅酸盐沸石中吸附剂驱动的动态活性位点

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-01-01 DOI: 10.1016/j.fmre.2022.12.015

Xianfeng Yi , Yao Xiao , Changjiu Xia , Fengqing Liu , Yujia Liu , Yu Hui , Xin Yu , Yucai Qin , Wei Chen , Zhiqiang Liu , Lijuan Song , Anmin Zheng

{"title":"Adsorbate-driven dynamic active sites in stannosilicate zeolites","authors":"Xianfeng Yi , Yao Xiao , Changjiu Xia , Fengqing Liu , Yujia Liu , Yu Hui , Xin Yu , Yucai Qin , Wei Chen , Zhiqiang Liu , Lijuan Song , Anmin Zheng","doi":"10.1016/j.fmre.2022.12.015","DOIUrl":"10.1016/j.fmre.2022.12.015","url":null,"abstract":"<div><div>Elucidating the nature of the active sites in heterogeneous catalysts is fundamental for understanding their reactivity and catalytic performances. Although stannosilicate zeolites have tremendous application potential for catalyzing biomass-related compounds in aqueous media, the detailed local structures and features of the real active sites and their possible structural variations under reaction conditions are poorly understood to date. In this study, a dynamic transformation of framework Sn−O−Si sites to Sn−OH/Si−OH pairs and subsequently a pseudo-Brønsted acid in stannosilicate zeolites upon molecular adsorption, which is analogous to various adsorbates/reactants under working conditions, was identified by solid-state nuclear magnetic resonance (NMR) spectroscopy for the first time, which challenges the widespread assumption that the active center structures remain rigid/stable during the catalytic process. These results provide new comprehensive insights for the fundamental understanding of the dynamic and flexible active centers and involved reaction mechanisms of novel zeolite catalysts with heterometal atoms, such as Sn, Ti, and Zr.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 1","pages":"Pages 174-182"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45353108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

End-to-end dataflow engineering framework of honey manufacturing from intermediates to process by TAS1R2@AuNPs/SPCE biosensor coupled with quality transfer principle 蜂蜜生产从中间体到加工的端到端数据流工程框架TAS1R2@AuNPs/结合质量传递原理的SPCE生物传感器

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-01-01 DOI: 10.1016/j.fmre.2022.09.029

Xiaoyan Hu , Jingqi Zeng , Lijuan Ma , Xiaomeng Wang , Jing Du , Lu Yao , Zhisheng Wu

{"title":"End-to-end dataflow engineering framework of honey manufacturing from intermediates to process by TAS1R2@AuNPs/SPCE biosensor coupled with quality transfer principle","authors":"Xiaoyan Hu , Jingqi Zeng , Lijuan Ma , Xiaomeng Wang , Jing Du , Lu Yao , Zhisheng Wu","doi":"10.1016/j.fmre.2022.09.029","DOIUrl":"10.1016/j.fmre.2022.09.029","url":null,"abstract":"<div><div>This study reported an original end-to-end dataflow engineering framework for the quality transfer principle to overcome the quality challenges in real-world honey manufacturing. Firstly, 650 pivotal data points of physical and chemical quality attributes from 65 batches of honey intermediates were characterized through multiple sensors, which included rheological properties, acidity, moisture, and sugars. Furthermore, a hypersensitized TAS1R2@AuNPs/SPCE biosensor was developed to identify biological quality attributes of honey, the powerful affinities between honey intermediates and the TAS1R2 receptor were discovered (K<sub>D</sub> < 1 × 10<sup>−8</sup> M), and the abnormal batches of B2, B23 and C23 were diagnosed by TAS1R2@AuNPs/SPCE biosensor and multivariable algorithm. Finally, the end-to-end dataflow containing physical, chemical and biological critical quality attributes was successfully established to interpret the quality transfer principle of honey manufacturing, which revealed that the front-end refining process was relatively unstable and the back-end refining process was a negligible influence on the quality of honey manufacturing. This framework embraces quality management, quality transfer, and biosensor information, which will contribute to discovering the quality transfer principle in industrial innovation for intelligent manufacturing.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 1","pages":"Pages 407-418"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48873167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of GaN RF devices and power amplifiers for 5G communication applications 面向 5G 通信应用的氮化镓射频器件和功率放大器综述

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-01-01 DOI: 10.1016/j.fmre.2023.11.005

Hao Lu , Meng Zhang , Ling Yang , Bin Hou , Rafael Perez Martinez , Minhan Mi , Jiale Du , Longge Deng , Mei Wu , Srabanti Chowdhury , Xiaohua Ma , Yue Hao

引用次数: 0

Modeling the modulation of beta oscillations in the basal ganglia by dual-target optogenetic stimulation 模拟双目标光遗传刺激对基底神经节β振荡的调控

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-01-01 DOI: 10.1016/j.fmre.2024.01.014

Xiaomin Wang , Ying Yu , Qingyun Wang

{"title":"Modeling the modulation of beta oscillations in the basal ganglia by dual-target optogenetic stimulation","authors":"Xiaomin Wang , Ying Yu , Qingyun Wang","doi":"10.1016/j.fmre.2024.01.014","DOIUrl":"10.1016/j.fmre.2024.01.014","url":null,"abstract":"<div><div>Optogenetic techniques provide precise control over the activity of specific neurons within the nucleus, offering more accurate regulatory effects compared to deep brain stimulation. The heterogeneity of the globus pallidus externa (GPe) has garnered wide attention, wherein significant differences in pathological changes emphasize its potential as a stimulation target with distinct mechanisms. A basal ganglia-thalamus (BG-Th) network model incorporating heterogeneous GPe is developed to explore potential optogenetic stimulation targets for treating Parkinson's disease (PD). Initially, the modulation mechanisms of single-target optogenetic stimulation on the abnormal rhythmic oscillations of BG nuclei are examined. Excitation of D1 medium spine neuron (MSN), calcium-binding protein parvalbumin (PV) GPe, and inhibition of globus pallidus interna (GPi) can effectively suppress synchronous bursting activity in GPi, while excitation of GPi promotes high-frequency discharge to disrupt beta oscillations. Furthermore, dual-target optogenetic stimulation strategies are devised to reduce energy consumption. Results show that targets with similar mechanisms exhibit additive effects, whereas targets with opposing mechanisms lead to cancellation. The underlying effective mechanisms of dual-target strategies are: enhancing the inhibitory input to GPi thus inhibiting the activity of GPi, or disrupting beta oscillations by restoring high-frequency discharges in GPi. The strategy composed of exciting D1 MSN and inhibiting GPi requires the minimum total light intensity among single-target and dual-target strategies in our simulation. Furthermore, simultaneously enhancing PV GPe and inhibiting D2 MSN achieves the greatest reduction in total energy consumption (40.8% reduction), compared to only enhancing PV GPe. The findings unveil effective circuit mechanisms of optogenetic stimulation and provide novel insights for designing precise regulatory strategies for PD.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 1","pages":"Pages 82-92"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139876348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of nucleus accumbens deep brain stimulation in treating mental disorders 深部脑核刺激治疗精神障碍的机制

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-01-01 DOI: 10.1016/j.fmre.2024.06.009

Hanyang Ruan , Geya Tong , Minghui Jin , Kathrin Koch , Zhen Wang

{"title":"Mechanisms of nucleus accumbens deep brain stimulation in treating mental disorders","authors":"Hanyang Ruan , Geya Tong , Minghui Jin , Kathrin Koch , Zhen Wang","doi":"10.1016/j.fmre.2024.06.009","DOIUrl":"10.1016/j.fmre.2024.06.009","url":null,"abstract":"<div><div>Growing evidence supports the effectiveness of deep brain stimulation (DBS) in treating various psychiatric disorders. DBS has the potential to selectively stimulate specific subcortical brain areas thus providing high-frequency electric stimulation of these regions. The nucleus accumbens (NAc), a frequent DBS target, has shown promise in treating psychiatric conditions like depression, obsessive-compulsive disorder, and addiction. In this review, we provide an overview across studies investigating the effects of NAc DBS in humans and animals and discuss potential mechanisms underlying its clinical efficacy. We address the anatomical properties of NAc and discuss, in particular, the frequently reported differential effects of NAc shell and NAc core DBS. Moreover, by outlining the various NAc cell types, transmitter systems (i.e., predominantly GABAergic and dopaminergic systems) and anatomical pathways that have been shown to be relevant for NAc DBS stimulation effects, we aim to further elucidate the neurobiological determinants of NAc DBS efficacy. Finally, since treatment effects of NAc DBS are most probably also related to alterations in NAc connected circuits or networks, we review studies focusing on the investigation of NAc DBS network effects. By examining these various components that are assumed to be of relevance in the context of NAc DBS, this review will hopefully contribute to increasing our knowledge about the mechanisms underlying NAc DBS and optimizing future selection of optimal DBS targets.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 1","pages":"Pages 48-54"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141712941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical biomarkers for responsive deep brain stimulation and responsive focal cortex stimulation in epilepsy field

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-01-01 DOI: 10.1016/j.fmre.2024.05.018

Zhikai Yu , Binghao Yang , Penghu Wei , Hang Xu , Yongzhi Shan , Xiaotong Fan , Huaqiang Zhang , Changming Wang , Jingjing Wang , Shan Yu , Guoguang Zhao

{"title":"Critical biomarkers for responsive deep brain stimulation and responsive focal cortex stimulation in epilepsy field","authors":"Zhikai Yu , Binghao Yang , Penghu Wei , Hang Xu , Yongzhi Shan , Xiaotong Fan , Huaqiang Zhang , Changming Wang , Jingjing Wang , Shan Yu , Guoguang Zhao","doi":"10.1016/j.fmre.2024.05.018","DOIUrl":"10.1016/j.fmre.2024.05.018","url":null,"abstract":"<div><div>To derive critical signal features from intracranial electroencephalograms of epileptic patients in order to design instructions for feedback-type electrical stimulation systems. The Detrended Fluctuation Analysis (DFA) exponent is chosen as the classification exponent, and the disparities between indicators representing distinct seizure states and the classification efficacy of rudimentary machine learning models are computed. The DFA exponent exhibited a statistically significant variation among the pre-ictal, ictal period, and post-ictal stages. The Linear Discriminant Analysis model demonstrates the highest accuracy among the three basic machine learning models, whereas the Naive Bayesian model necessitates the least amount of computational and storage space. The set of DFA exponents is employed as an intermediary variable in the machine learning process. The resultant model possesses the capability to function as a feedback trigger program for electrical stimulation systems of the feedback variety, specifically within the domain of neural modulation in epilepsy.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 1","pages":"Pages 103-114"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Last digit tendency: Lucky numbers and psychological rounding in mobile transactions 最后一位数倾向：移动交易中的幸运数字和心理四舍五入

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-01-01 DOI: 10.1016/j.fmre.2023.11.011

Hai Wang , Tian Lu , Yingjie Zhang , Yue Wu , Yiheng Sun , Jingran Dong , Wen Huang

{"title":"Last digit tendency: Lucky numbers and psychological rounding in mobile transactions","authors":"Hai Wang , Tian Lu , Yingjie Zhang , Yue Wu , Yiheng Sun , Jingran Dong , Wen Huang","doi":"10.1016/j.fmre.2023.11.011","DOIUrl":"10.1016/j.fmre.2023.11.011","url":null,"abstract":"<div><div>The distribution of digits in numbers obtained from different sources reveals interesting patterns. The well-known Benford’s law states that the first digits in many real-life numerical data sets have an asymmetric, logarithmic distribution in which small digits are more common; this asymmetry diminishes for subsequent digits, and the last digit tends to be uniformly distributed. In this paper, we investigate the digit distribution of numbers in a large mobile transaction data set with 835 million mobile transactions and payments made by approximately 460,000 users in more than 300 cities. Although the first digits of the numbers in these mobile transactions follow Benford’s law, the last digit has a strong tendency to be a lucky number or be influenced by psychological rounding. This lucky number tendency is more significant in transactions that are more strongly connected to social interactions, such as money sent as gifts or as “red envelopes” (a traditional method of gift-giving during Chinese holidays), and in transactions by individuals with potentially greater emotional needs, such as during COVID-19 outbreaks and natural disasters. This psychological rounding tendency is more common in online e-commerce payments, in-store purchases, and money transfers between individuals. These findings are key for understanding the last digit tendency and its psychological and emotional mechanisms, which could be used as an indicator of public sentiment or in methods of detecting fraudulent business activity.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 1","pages":"Pages 370-378"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139013349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous recording of neuronal discharge and calcium activity reveals claustrum-cortex neurosynchrony under anesthesia 同时记录神经元放电和钙离子活动揭示麻醉状态下大脑皮层与耳廓的神经同步性

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-01-01 DOI: 10.1016/j.fmre.2023.12.012

Penghui Fan , Rujin Zhang , Guihua Xiao , Yilin Song , Chaowei Zhuang , Lekang Yuan , Fan Mo , Botao Lu , Zhaojie Xu , Yiding Wang , Jinping Luo , Mixia Wang , Weidong Mi , Jiangbei Cao , Qionghai Dai , Xinxia Cai

{"title":"Simultaneous recording of neuronal discharge and calcium activity reveals claustrum-cortex neurosynchrony under anesthesia","authors":"Penghui Fan , Rujin Zhang , Guihua Xiao , Yilin Song , Chaowei Zhuang , Lekang Yuan , Fan Mo , Botao Lu , Zhaojie Xu , Yiding Wang , Jinping Luo , Mixia Wang , Weidong Mi , Jiangbei Cao , Qionghai Dai , Xinxia Cai","doi":"10.1016/j.fmre.2023.12.012","DOIUrl":"10.1016/j.fmre.2023.12.012","url":null,"abstract":"<div><div>Neural information transmission between deep brain nuclei and the cortex is essential for brain function. Currently, high-resolution simultaneous detection of neural information between the deep brain nuclei and the large-scale cortex still poses challenges. We have developed the microelectrode arrays based on the Micro-Electro-Mechanical System technology, and modified the electrode surface with nanomaterials to improve the electrode performance. This study combined microelectrode arrays and extended-field-of-view microscopy to achieve simultaneous recording of claustrum (CLA) electrophysiology and wide-field cortical calcium imaging at single-cell resolution. This work investigated the synchronous changes of neural information in CLA and cortex of mice during the whole process from wakefulness to anesthesia and then to wakefulness, and summarized the characteristics of the CLA electrophysiology and cortical calcium signaling under different inhalation anesthesia concentrations. We found the synergy between microscopic spike and local field potential of CLA neurons under deep anesthesia, and the law that high inhalation anesthesia concentration enhanced the synchronization between neurons in CLA and cortex. The combination of microelectrode arrays and extended-field-of-view microscopy also gives a new method for synchronous detection of multimodal and multi-brain region neural information.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 1","pages":"Pages 93-102"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139891832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SDG space: Revealing the structure and complementarities among sustainable development goals in China 可持续发展目标空间：揭示中国可持续发展目标的结构与互补性

IF 6.2 3区综合性期刊

Fundamental Research Pub Date : 2025-01-01 DOI: 10.1016/j.fmre.2024.01.005

Mimi Gong , Ke Yu , Changchang Zhou , Zhouyi Liu , Zhenci Xu , Ming Xu , Shen Qu

{"title":"SDG space: Revealing the structure and complementarities among sustainable development goals in China","authors":"Mimi Gong , Ke Yu , Changchang Zhou , Zhouyi Liu , Zhenci Xu , Ming Xu , Shen Qu","doi":"10.1016/j.fmre.2024.01.005","DOIUrl":"10.1016/j.fmre.2024.01.005","url":null,"abstract":"<div><div>To achieve the United Nations Sustainable Development Goals (SDGs) by 2030, it is essential to understand the interlinkages between the goals. Previous research has investigated these interactions by focusing on their correlations. However, few studies have systematically prioritized them from a structural perspective through the complementarity measurements and empirically validated their policy effectiveness, such as which goals and indicators impact other SDGs most, especially in China. This study introduces a new concept known as the ‘SDG space’ by employing the “Product Space” approach in network science and economics. It measures the complementarities between SDGs and indicators through their network structures in investigating effective policy design. Using the most recent available but unpublished data for 31 Chinese provinces, the SDG space was constructed at the 17 SDG and 118 indicator levels by analyzing the probability of comparative advantage between each SDG or indicator pair co-occurring in the same place. Historical data confirm that in the ‘SDG Space’ network, a goal connected to other well-developed goals would enjoy better future growth and vice versa. The structure reveals that SDG 4 (Quality Education), 15 (Life on Land), and 1 (No Poverty) are critical goals with transformative synergies to other SDGs. Furthermore, we identified strong complementarities between land-based ecosystems and clean water and climate actions using the finer-grained indicator-level space. These findings help pave the way for China toward a sustainable future by providing science-based policy recommendations for decision-makers. They can be generally applied to other countries and regions to assist in navigating toward sustainable development.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 1","pages":"Pages 360-369"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140465815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0