肠道微生物群和肝脏疾病

IF 6.2 3区综合性期刊 Q1 Multidisciplinary

Fundamental Research Pub Date : 2025-03-01 DOI:10.1016/j.fmre.2024.09.007

Jun Xu , Ning Chen , Zhou Li , Yulan Liu

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引用次数: 0

摘要

共生菌群在宿主免疫系统的教育、发育和维持中起着至关重要的作用，对整体健康有重要贡献。通过肠-肝轴，肠道菌群和肝脏具有双向关系，随着越来越多的研究强调肠道菌群及其代谢物的易位，这种关系越来越明显。这篇叙述性综述的重点是检查和讨论肠肝轴和肠肝屏障在维持整体健康中的重要性。此外，我们强调肠道微生物群在肝脏疾病中的关键作用，并通过操纵微生物群探索肝脏疾病的潜在治疗策略。

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Gut microbiome and liver diseases

Symbiotic microbiota plays a crucial role in the education, development, and maintenance of the host immune system, significantly contributing to overall health. Through the gut-liver axis, the gut microbiota and liver have a bidirectional relationship that is becoming increasingly evident as more research highlights the translocation of the gut microbiota and its metabolites. The focus of this narrative review is to examine and discuss the importance of the gut-liver axis and the enterohepatic barrier in maintaining overall health. Additionally, we emphasize the crucial role of the gut microbiome in liver diseases and explore potential therapeutic strategies for liver diseases by manipulating the microbiota.

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