Fundamental Research最新文献_第5页

Base-assisted elemental sulfur-based multicomponent polymerizations to synthesize asymmetric polythioureas 碱辅助单质硫基多组分聚合合成不对称聚硫脲

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-03-01 Epub Date: 2025-12-12 DOI: 10.1016/j.fmre.2025.12.006

Wenxia Cao , Rui Luo , Rongrong Hu , Ben Zhong Tang

{"title":"Base-assisted elemental sulfur-based multicomponent polymerizations to synthesize asymmetric polythioureas","authors":"Wenxia Cao , Rui Luo , Rongrong Hu , Ben Zhong Tang","doi":"10.1016/j.fmre.2025.12.006","DOIUrl":"10.1016/j.fmre.2025.12.006","url":null,"abstract":"<div><div>Polythioureas with great potential in precious metal recovery materials, dielectric materials, light refractive materials, self-healing materials, and adhesives have become a group of popular polymer materials. While various synthetic approaches have been reported for different polythiourea structures, which generally involve expensive and toxic monomers, several polythiourea structures, such as asymmetric aromatic polythioureas, still have limited access. Herein, a base-catalyzed multicomponent polymerization (MCP) of elemental sulfur, diisocyanides, and diamines was developed, which was generally applicable for both aromatic amines with low reactivity and aliphatic amines with high nucleophilicity, affording polythioureas with great structural diversity, high <em>M</em><sub>w</sub>s of up to 107,700 g/mol and high yields of up to 99%. Moreover, aromatic polythioureas with different aromatic spacers installed on each side of the thiourea moiety could be facilely synthesized. Amine exchange reactions were studied for thiourea compounds or polythioureas, indicating that the C<img>N bonds of the thiourea moiety on the aromatic substitute side were more labile compared with those on the aliphatic substitute side, rendering the potential controllable degradation of different polythiourea structures. The polythioureas generally possess high thermal stability, with the glass transition temperatures ranging from 121 to 169 °C. These polythioureas could efficiently absorb Hg<sup>2+</sup> from polluted water, and aromatic polythioureas generally showed better performance compared with semi-aromatic and aliphatic polythioureas. This work has hence provided a general synthetic approach for various aliphatic, aromatic, and semi-aromatic polythioureas with symmetric or asymmetric thiourea structures. The dynamic covalent bond nature of thioureas endowed these polymer materials with controllable degradation, making them sustainable functional polymer materials.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 816-826"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147620757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tensor decomposition of transportation temporal and spatial big data: A brief review 交通运输时空大数据张量分解研究综述

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-03-01 Epub Date: 2024-09-25 DOI: 10.1016/j.fmre.2024.03.032

Linchao Li , Xiang Lin , Bin Ran , Bowen Du

引用次数: 0

Virtual energy shortage risk to trade network in China 中国贸易网络的虚拟能源短缺风险

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-03-01 Epub Date: 2025-11-13 DOI: 10.1016/j.fmre.2025.11.005

Hanlei Wang , Hui Li , Yulei Xie , Frederick Kwame Yeboah , Zhiyao Ding , Gengyuan Liu , Yixuan Wang

{"title":"Virtual energy shortage risk to trade network in China","authors":"Hanlei Wang , Hui Li , Yulei Xie , Frederick Kwame Yeboah , Zhiyao Ding , Gengyuan Liu , Yixuan Wang","doi":"10.1016/j.fmre.2025.11.005","DOIUrl":"10.1016/j.fmre.2025.11.005","url":null,"abstract":"<div><div>Local energy shortages can directly lead to economic output losses in energy-intensive sectors, known as local energy shortage risk (LESR). Additionally, the impacts of local energy shortages can propagate through supply chains, creating cascading effects that induce potential indirect economic losses in external regions and sectors, termed virtual energy shortage risk (VESR). This study quantifies the propagation of VESR across China’s regional trade network from 2012 to 2017, uncovering the systemic risk posed by local energy shortages. The results show that VESR accounted for a substantial proportion (41.0–43.9%) of China’s energy shortage risk (ESR, the sum of LESR and VESR) during the study period, highlighting the significance of indirect impacts. LESR and VESR exhibit notable geographic separation. For instance, Tibet experienced no LESR but is exposed to VESR. VESR exporters are concentrated in energy-intensive sectors within energy-scarce regions, such as “Metal Smelting and Pressing” in Hebei and Henan. In contrast, VESR importers are more widely distributed; sectors such as “Agriculture Services” and “Coal Mining and Dressing” in Beijing, experience VESR imports exceeding 50% of their ESR, indicating high external risk exposure. These findings highlight the need for inter-regional coordination in energy resource management and provide risk mitigation pathways for VESR importers (e.g., diversifying supply sources and strengthening energy supply technology cooperation with upstream regions).</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 647-658"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147620889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Earthworm gut’s potential positive impact on carbon cycle by influencing carbohydrate metabolism and microbial genome size 蚯蚓肠道通过影响碳水化合物代谢和微生物基因组大小对碳循环的潜在积极影响

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-03-01 Epub Date: 2025-03-29 DOI: 10.1016/j.fmre.2025.03.018

Shuai Du , Da Lin , Tian-Lun Zhang , Hai-Yan Chu , Dong Zhu

{"title":"Earthworm gut’s potential positive impact on carbon cycle by influencing carbohydrate metabolism and microbial genome size","authors":"Shuai Du , Da Lin , Tian-Lun Zhang , Hai-Yan Chu , Dong Zhu","doi":"10.1016/j.fmre.2025.03.018","DOIUrl":"10.1016/j.fmre.2025.03.018","url":null,"abstract":"<div><div>The earthworm microbiome significantly impacts global soil ecosystems. This study explores how earthworm gut eukaryome (fungi and protists) and functional genes respond to land use and climatic factors. Over 150 earthworm–soil sample pairs were collected from arable and forest ecosystems across China. High-throughput and shotgun metagenomic sequencing revealed lower fungal, protistan, and CAZyme gene diversities in the earthworm gut than in the soil (0.77-fold, 0.19-fold, and 0.74-fold compared to the soil, respectively), but higher proportions of parasitic protists (3.78-fold compared to the soil) and carbohydrate metabolism genes involved in glycosyl transfer (1.41-fold compared to the soil). Arable systems showed higher abundances of functional genes associated with carbon fixation, nitrification, phosphorus dissolution, and sulfite reduction compared to forest systems. This study highlights the associations between earthworm gut microeukaryotes and functional genes especially glycosyl transferases involved in carbohydrate biosynthesis. Furthermore, larger microbial genomes were found in the earthworm gut compared to the soil, which may harbor more functional genes involved in cellular processes, carbohydrate binding, and glycosyl transfer. These findings suggest that earthworm gut microeukaryotes may have a positive impact on their average genome sizes and carbohydrate metabolism within the carbon cycle. This study contributes to advancing our understanding of the functionality of microeukaryotes in the earthworm gut, especially for the carbon cycle.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 837-846"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147620847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promoting Cl2O generation from the HOCl + HOCl reaction on aqueous/frozen air–water interfaces 促进水/冷冻空气-水界面上HOCl + HOCl反应生成Cl2O

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-03-01 Epub Date: 2025-03-31 DOI: 10.1016/j.fmre.2025.03.016

Weina Zhang , Dayuan Zheng , Haolin Han , Zhengyi Wan , Jie Zhong , Yuemeng Ji , Guiying Li , Joseph S. Francisco , Taicheng An

引用次数: 0

Pore segmentation and shielding: A dual strategy to prepare sub-nanometer covalent-organic-framework based membranes for selective metal ion sieving 孔隙分割和屏蔽：制备亚纳米共价有机框架膜以选择性筛分金属离子的双重策略

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-03-01 Epub Date: 2023-12-09 DOI: 10.1016/j.fmre.2023.09.008

Yingdan Zhang , Ningning He , Jie Zhang , Zhimin Jia , Xiaofeng Li , Ning Liu , Yang Li , Lijian Ma

{"title":"Pore segmentation and shielding: A dual strategy to prepare sub-nanometer covalent-organic-framework based membranes for selective metal ion sieving","authors":"Yingdan Zhang , Ningning He , Jie Zhang , Zhimin Jia , Xiaofeng Li , Ning Liu , Yang Li , Lijian Ma","doi":"10.1016/j.fmre.2023.09.008","DOIUrl":"10.1016/j.fmre.2023.09.008","url":null,"abstract":"<div><div>The extensive use of nuclear energy has led to an urgent need for effective management of radioactive waste. Membrane separation of radionuclides is considered to be a promising method for nuclear waste treatment and resource recovery. However, most reported membranes have difficulties achieving a balance between permeability and selectivity. In this work, we propose a dual strategy to produce sub-nanometer COF-based membranes, which includes constructing covalent organic frameworks (COFs) from smaller building blocks (‘pore segmentation’) and introducing a graphene oxide (GO) nanosheet by weak interaction to shield pores (‘pore shielding’) during the preparation of COF membranes. The as-prepared TpDAH@GO membrane shows two times higher permeability (<em>P</em><sub>K</sub> = 4.5 mmol m<sup>−2</sup> h<sup>−1</sup>) than that of pure GO membrane due to the retention of unique ‘pore transport’ of COFs. In addition, the selectivity of TpDAH@GO membrane for metal ion sieving (<em>S</em><sub>K/Th</sub> = 3.93) nearly doubles when compared with that of the original COF membrane, due to the additional introduction of ‘interlayer transport’. The dual strategy proposed in this study successfully constructed a sub-nanometer COF-based membrane and achieved a valuable balance between permeability and selectivity on the membrane, which provides new possibilities for the pore regulation of COF membranes as well as the preparation of high-performance sub-nanometer membranes for efficient metal ion sieving.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 790-796"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138620335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

L-palmitoylcarnitine supplementation improves oocyte quality and embryo development derived from obese mice 补充左旋棕榈酰肉碱可改善肥胖小鼠卵母细胞质量和胚胎发育

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-03-01 Epub Date: 2024-06-06 DOI: 10.1016/j.fmre.2024.05.013

Juan Ge , Junjie Guo , Xiang Zhang , Weizheng Yang , Longsen Han , Hongzheng Sun , Hui Wang , Qiang Wang

{"title":"L-palmitoylcarnitine supplementation improves oocyte quality and embryo development derived from obese mice","authors":"Juan Ge , Junjie Guo , Xiang Zhang , Weizheng Yang , Longsen Han , Hongzheng Sun , Hui Wang , Qiang Wang","doi":"10.1016/j.fmre.2024.05.013","DOIUrl":"10.1016/j.fmre.2024.05.013","url":null,"abstract":"<div><div>Changes in fatty acid composition caused by diet or exposure to diets that promote obesity can impact the quality of eggs and embryos, as well as the health of the resulting offspring. Palmitoylcarnitine, as an important intermediate for fatty acid transport across the inner mitochondrial membrane, undergoes a substantial increase during oocyte maturation. However, its impact on oocyte/embryo development remains unknown. In the present study, by establishing a high-fat diet (HFD)-induced model of obesity, we systematically evaluated the effects of palmitoylcarnitine supplementation on oocyte competence and embryo quality derived from obese mice. We found that palmitoylcarnitine supplement during <em>in vitro</em> culture markedly ameliorates the meiotic defects and genomic instability in HFD oocytes. The abnormal mitochondrial distribution and the lowered mitochondrial membrane potential in HFD oocytes are also prevented simultaneously, indicative of the improved mitochondrial function. Moreover, palmitoylcarnitine administration is capable of suppressing blastocyst apoptosis and promoting early embryo development from HFD mice. Taken together, our results suggest that palmitoylcarnitine has beneficial effects on oocyte quality exposed to maternal obesity via modulating meiotic structure and energy metabolism.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 1215-1221"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141414559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis 通过低温电子显微镜分析揭示龙蛋白酶的分叉组装途径和双重功能

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-03-01 Epub Date: 2024-04-19 DOI: 10.1016/j.fmre.2024.02.020

Ming Li , Hongwei Liu , Kan-Yen Hsieh , Shengchun Zhang , Yongxiang Gao , Qingguo Gong , Kaiming Zhang , Chung-I Chang , Shanshan Li

{"title":"Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis","authors":"Ming Li , Hongwei Liu , Kan-Yen Hsieh , Shengchun Zhang , Yongxiang Gao , Qingguo Gong , Kaiming Zhang , Chung-I Chang , Shanshan Li","doi":"10.1016/j.fmre.2024.02.020","DOIUrl":"10.1016/j.fmre.2024.02.020","url":null,"abstract":"<div><div>The Lon proteases are evolutionarily conserved oligomeric hydrolases characterized by a built-in ATPase module. Here, we report the structures of LonC from <em>Meiothermus taiwanensis</em> (MtaLonC), a unique member in the Lon protein family with a dual chaperone-protease function but lacking ATPase activity, determined by cryo-electron microscopy (cryo-EM). In its apo state, LonC forms phosphate-bound open-ring pentamers, open-ring hexamers, and close-ring heptamers. However, upon interaction with ATPγS, inhibitor, or substrate, MtaLonC assembles into close-ring hexamers, wherein the protease domain's substrate-binding loop adopts an extended active conformation. We show that proteolytic and chaperone activities may be carried out by the close-ring hexameric and heptameric forms, respectively. We further show that MtaLonC forms exclusively close-ring heptamers at elevated temperatures. This study sheds light on the bifurcated assembly pathway of MtaLonC, leading to two distinct oligomeric close-ring complexes that carry out a dual function.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 879-884"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140794915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical communication and function regulation of immune cells 免疫细胞的机械通信和功能调节

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-03-01 Epub Date: 2024-04-12 DOI: 10.1016/j.fmre.2024.04.008

Chen Yang , Ruipei Xie , Ting Cao , Yiyu Zhang , Xiaochen Wang , Ye Xu , Qihui Fan , Fangfu Ye

引用次数: 0

Transboundary algal migration-induced systemic environmental risk in the Yangtze River Basin, China 长江流域藻类跨界迁移引发的系统性环境风险

IF 6.3 3区综合性期刊

Fundamental Research Pub Date : 2026-03-01 Epub Date: 2025-12-08 DOI: 10.1016/j.fmre.2025.12.003

Qingsong Jiang , Haiping Huang , Zhen Wu , Kaikui Cai , Lian Hu , Yue Qin , Zhen Guo , Yong Liu

{"title":"Transboundary algal migration-induced systemic environmental risk in the Yangtze River Basin, China","authors":"Qingsong Jiang , Haiping Huang , Zhen Wu , Kaikui Cai , Lian Hu , Yue Qin , Zhen Guo , Yong Liu","doi":"10.1016/j.fmre.2025.12.003","DOIUrl":"10.1016/j.fmre.2025.12.003","url":null,"abstract":"<div><div>The horizontal transport of algal biomass or populations across administrative or ecosystem boundaries via hydrological connectivity poses systemic environmental risks in the Yangtze River Basin, despite recent improvements in river or lake water quality. Here, we investigated the dynamics of algal biomass along the Yangtze River mainstream through high-resolution monitoring spanning from February 2023 to December 2024. Results demonstrated a consistent increase in average chlorophyll-a concentrations from 4 µg/L to 8 µg/L between the Three Gorges Dam and Lake Dongting outlet. Random Forest and SHAP analysis identified water temperature as the strongest driver of algal biomass variation (36.6%), followed by total nitrogen (25.9%) and total phosphorus (23.6%). Interestingly, ship traffic generated previously overlooked thermal pollution, with navigational channels exhibiting ∼1 °C higher temperatures than adjacent shorelines. As a result, bidirectional hydrological connections between the Yangtze River and connected lakes facilitate transboundary algal migration, undermining lake-specific restoration efforts and exacerbating basin-wide ecological instability. These findings necessitate a paradigm shift from localized to integrated, basin-scale management. Furthermore, a framework that synergistically addresses algal migration, thermal pollution, and nutrient dynamics is urgently needed to mitigate systemic environmental risks in the Yangtze River Basin.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 2","pages":"Pages 583-586"},"PeriodicalIF":6.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147620616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0