Current Research in Microbial Sciences最新文献

{"title":"Multiple influences on cyanobacterial abundance and diversity in the Beijing-Tianjin-Hebei Economic Circle and nearby areas of China","authors":"Wei Wang,&nbsp;Hanjie Huang,&nbsp;Kangxu Zhao,&nbsp;Junping Lv,&nbsp;Xudong Liu,&nbsp;Shulian Xie,&nbsp;Jia Feng","doi":"10.1016/j.crmicr.2025.100400","DOIUrl":"10.1016/j.crmicr.2025.100400","url":null,"abstract":"<div><div>In recent years, there has been a marked increase in the frequency and duration of cyanobacterial blooms, which has attracted widespread attention from all sectors of society. However, the processes and pathways leading to the formation of cyanobacterial blooms are largely stochastic, and a targeted quantitative model incorporating multiple drivers is required. A series of fieldwork and analytical procedures were conducted on 11 lakes in Beijing-Tianjin-Hebei and neighboring regions. The objective of this research was to investigate the effects of location, climate, habitat, metabolism and biology on the abundance of cyanobacteria. The findings indicated that location factors exerted an indirect influence on cyanobacterial density, with a calculated effect size of −0.001. This observation is consistent with the documented prevalence of cyanobacterial bloom outbreaks, suggesting that cyanobacterial abundance is not directly associated with location. Furthermore, the water environment (0.35 indirect and −0.37 direct effects) and climatic conditions (−0.2 indirect and 0.16 direct effects) had significant direct and indirect effects on cyanobacterial cell densities. It was also determined that high nutrients and high temperatures remained the basis for promoting cyanobacterial blooms. It is noteworthy that the microbial community exerted a substantial inhibitory effect on the proliferation of the cyanobacterial community (1.13 direct inhibitory effect). It is hypothesized that the negative effect is derived from two primary sources: the competition for ecological niches by organisms exhibiting similarity, and the direct inhibitory effect of certain bacteria on the growth of cyanobacteria, a negative correlation between acidobacteriota, bacteroide and a variety of cyanobacteria was observed in our study. The effect of specific bacteria is found to be significantly negatively correlated with the prevalence of a wide range of cyanobacteria, which is consistent with the results of many extant studies. These extant studies indicate that the formation of cyanobacterial communities is primarily influenced by microorganisms in the environment. The results of this study will provide new and complementary evidence on the mechanisms of cyanobacterial bloom occurrence and development and the design of management strategies.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"8 ","pages":"Article 100400"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening and discovery of an antiviral candidate inhibiting the SARS-CoV-2 envelope (2-E) channel","authors":"Han Zhang ,&nbsp;Shuxin Shi ,&nbsp;Lujia Sun ,&nbsp;Shuangqu Li ,&nbsp;Yan Zhang ,&nbsp;Ziyue Li ,&nbsp;Jingjing Hou ,&nbsp;Pingan Li ,&nbsp;Jingshan Shen ,&nbsp;Xi Cheng ,&nbsp;Shibo Jiang ,&nbsp;Zhaobing Gao ,&nbsp;Xinling Wang ,&nbsp;Xiangrui Jiang ,&nbsp;Bingqing Xia","doi":"10.1016/j.crmicr.2025.100409","DOIUrl":"10.1016/j.crmicr.2025.100409","url":null,"abstract":"<div><div>The SARS-CoV-2-encoded 2-E channel is critical in the viral life cycle and pathogenesis. By facilitating viral replication, it promotes the dysregulation of inflammatory pathways, leading to cytokine storm, and triggers DNA damage response (DDR), thus exacerbating disease progression. The 2-E channel, a viroporin, is a promising antiviral target. However, the lack of specific inhibitors and effective screening methods has hindered therapeutic exploitation of the 2-E channel. To address this gap, we report on a fluorescence-based screening assay that targets the 2-E channel activity, resulting in the identification of potential inhibitory molecules. After performing both electrophysiological studies and surface plasmon resonance (SPR) analyses, we identified the top-ranked candidate, TPN10518, as a pore-blocking inhibitor of the 2-E channel. TPN10518 binds to a hydrophobic pocket in the C-terminal vestibule of the 2-E channel, thereby inhibiting its activity. Functional evaluation showed that TPN10518 exhibits significant antiviral efficacy <em>in vitro</em>, while, at the same time, effectively protecting against 2-E channel-mediated host damage and suppressing cytokine storm caused by dysregulated homeostasis of inflammatory pathways <em>in vivo</em>. Therefore, our work introduces a screening method for targeting 2-E channels, establishes the 2-E channel as a viable therapeutic target against SARS-CoV-2, and identifies TPN10518 as a promising antiviral candidate.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"9 ","pages":"Article 100409"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell wall polysaccharide alters the surface electric potential of Lacticaseibacillus paracasei strain Shirota and enhances acid tolerance","authors":"Kosuke Kato,&nbsp;Madoka Nakamura,&nbsp;Masaki Serata,&nbsp;Takekazu Okumura","doi":"10.1016/j.crmicr.2025.100430","DOIUrl":"10.1016/j.crmicr.2025.100430","url":null,"abstract":"<div><div>LCPS-1 is a cell wall polysaccharide (CWPS) of <em>Lacticaseibacillus paracasei</em> (formerly <em>Lactobacillus casei</em>) strain Shirota (LcS). LCPS-1 enhances the acid tolerance of LcS; however, the mechanism of action remains unclear. This study aimed to elucidate how LCPS-1 enhances LcS growth and survivability under acidic conditions. When cultured in media acidified with hydrochloric, lactic, or acetic acid, wild-type LcS showed significantly more growth than an LCPS-1-deficient mutant strain (<em>p</em> &lt; 0.01), indicating that LCPS-1 confers enhanced protection against proton (<em>H</em>⁺) stress. Wild-type LcS also exhibited a significant 73–83 % reduction (<em>p</em> &lt; 0.01) in negative surface potential compared to that of the mutant. Additionally, wild-type LcS showed significantly more growth than the mutant (<em>p</em> &lt; 0.01) in the presence of cupric oxide, which releases bactericidal Cu²⁺ ions. In contrast, wild-type LcS was slightly more susceptible than the mutant to lethal concentrations of hydroxide ions. These findings suggest that LCPS-1 modulates the surface electric potential of LcS cells, thereby influencing the interaction strength between the cell walls and environmental ions, ultimately altering the tolerance of the cells to ionic stress factors. These findings provide crucial insights into the role of CWPSs in modulating the surface electric potential of microorganisms, which affects microbial interactions with environmental ions. This enhanced understanding of CWPS function enables the development of more resilient probiotic strains, potentially improving their efficacy in various industrial and therapeutic applications.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"9 ","pages":"Article 100430"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative multiplexed analysis of gene and protein expression patterns in Yarrowia lipolytica","authors":"Erin Bredeweg,&nbsp;Galya Orr,&nbsp;Dehong Hu","doi":"10.1016/j.crmicr.2025.100369","DOIUrl":"10.1016/j.crmicr.2025.100369","url":null,"abstract":"<div><div>In this report, we present coordinated observations of protein and mRNA transcript counts at the single-cell level in the oleaginous yeast model <em>Yarrowia lipolytica</em>. The transcription factor Xbp1p regulates entry into a quiescent state, representing a shift of resources to sequestration of nutrients rather than cell division. We observed the responses of wild-type and Δ<em>xbp1</em> cells to protein (by fluorescence) and transcript quantification and localization at both single-cell and population-averaged levels. Data were collected via single-molecule fluorescence <em>in situ</em> hybridization (smFISH) and qPCR under nitrogen depletion, a condition that drives lipid accumulation. These techniques reveal a complex and heterogeneous population of Xbp1p dynamics and downstream regulation. Our findings highlight the need for single-cell resolution analyses to describe cellular dynamics and regulatory processes.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"8 ","pages":"Article 100369"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144202455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unearthing the burden of melioidosis in North India – an emerging threat in a non-endemic region","authors":"Shweta Raina ,&nbsp;Disha Gautam ,&nbsp;Rohit Kumar ,&nbsp;Kavita Sisodia ,&nbsp;Chiranjay Mukhopadhyay ,&nbsp;Harpreet Kaur ,&nbsp;Mohammed Ashiq ,&nbsp;Rushika Saksena","doi":"10.1016/j.crmicr.2025.100344","DOIUrl":"10.1016/j.crmicr.2025.100344","url":null,"abstract":"<div><div><em>Burkholderia pseudomallei (B. pseudomallei)</em> is the causative agent of the high-mortality disease called melioidosis. It is a severe infection that can be misdiagnosed due to variable presentation and low awareness among clinicians of the disease. It is endemic in India and well-described in southern and eastern coastal states. In the last decade, sporadic cases of melioidosis have been diagnosed in North Indian states, predominantly Rajasthan and Gujarat. The reported cases highlight the many risk factors for infection in this region that was not previously recognised as being endemic for melioidosis, including high prevalence of diabetes mellitus, alcoholism, and large rural population engaged in paddy cultivation. Climate change results in frequent flooding and waterlogging in urban areas, leading to exposure of soil harbouring <em>B. pseudomallei,</em> thus a contributing factor to the rise in cases in cities. As North India has not previously been considered an endemic region for melioidosis, wider awareness amongst clinicians and laboratorians is essential for early identification of symptoms, testing for <em>B. pseudomallei</em> in microbiology laboratories, and timely management of the disease to save lives lost to misdiagnosis. The present article describes various aspects of melioidosis in North India including diverse clinical manifestations, risk factors, and possible reasons for misdiagnosis and underreporting.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"8 ","pages":"Article 100344"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linalool exhibit antimicrobial ability against Elizabethkingia miricola by disrupting cellular and metabolic functions","authors":"Mingwang He ,&nbsp;Weiming Zhong ,&nbsp;Rongsi Dai ,&nbsp;Su Long ,&nbsp;Ying Zhou ,&nbsp;Tongping Zhang ,&nbsp;Boyang Zhou ,&nbsp;Tao Tang ,&nbsp;Linlin Yang ,&nbsp;Sifan Jiang ,&nbsp;Wenbin Xiao ,&nbsp;YanJiao Fu ,&nbsp;Jiajing Guo ,&nbsp;Zhipeng Gao","doi":"10.1016/j.crmicr.2025.100380","DOIUrl":"10.1016/j.crmicr.2025.100380","url":null,"abstract":"<div><div><em>Elizabethkingia miricola</em> is a gram-negative bacillus, a life-threatening pathogen in humans and animals. Linalool, a naturally occurring monoterpene alcohol found in plant volatile oils, exhibits highly effective antibacterial properties. This study investigated the antibacterial activity and mechanism of linalool against <em>E. miricola</em>. Initially, linalool showed potent antibacterial activity against <em>E. miricola</em>, with inhibition zone (ZOI), MIC, and MBC values of 36.41 ± 1.23 mm, 0.125 % (v/v, 1.0775 mg/mL), and 0.125 % (v/v, 1.0775 mg/mL), respectively. Secondly, it was observed by electron microscopy that linalool caused crumpling, depression, and size reduction of the cells. Linalool affected cell membrane integrity, causing membrane damage and rupture. Thirdly, transcriptome analysis suggested that linalool affected C5-branched-chain dicarboxylic acid metabolism and the biosynthesis of valine, leucine, and isoleucine, result in increased energy production to linalool stress. Linalool disrupted cell division and RNA function in <em>E. miricola</em>, and the cells responded to linalool-induced oxidative damage by up-regulating the expression of <em>msrB</em> and <em>katG</em> genes. Fourthly, metabolome analysis revealed an increase in metabolites related to the glycerophospholipid metabolic pathway and NADP content in <em>E. miricola</em>, which may be a metabolic response to linalool stress. Taken together, these findings provide a theoretical basis for the antibacterial mechanism of linalool and suggest potential applications for preventing <em>E. miricola</em> infections.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"8 ","pages":"Article 100380"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancement of production of pathogen-suppressing volatiles using amino acids","authors":"Christina Papazlatani ,&nbsp;Annabell Wagner ,&nbsp;Zhijun Chen ,&nbsp;Hans Zweers ,&nbsp;Wietse de Boer ,&nbsp;Paolina Garbeva","doi":"10.1016/j.crmicr.2025.100385","DOIUrl":"10.1016/j.crmicr.2025.100385","url":null,"abstract":"<div><div>Bacterial volatile organic compounds can play a significant role in antagonistic interactions. Enhancing the production of bacterial volatiles that suppress the growth of soil-borne phytopathogenic fungi, has perspective as a sustainable disease control strategy. In the present study, we explored the potential of stimulating <em>Burkholderia</em> AD24 and <em>Paenibacillus</em> AD87 to produce volatiles that suppress the growth of the plant pathogenic fungi <em>Fusarium culmorum</em> PV and <em>Rhizoctonia solani</em> AG2.2IIIb. We provided the bacterial strains with a mixture of amino acids that can serve as precursor molecules in metabolic routes leading to emission of suppressive bacterial volatiles. Only <em>Burkholderia</em> AD24 was stimulated to produce a volatile blend that led to higher suppression of both pathogens. Subsequent analysis of the volatile composition emitted by <em>Burkholderia</em> AD24 in the presence of amino acids, showed higher abundance of antifungal compounds, including sulfur compounds (DMDS), pyrazines (2,5-dimethyl pyrazine) and carbohydrates (3-methyl-1-butanol). Follow-up trials with single amino acids revealed a pathogen specific response effect. When <em>Burkholderia</em> AD24 was cultivated in the presence of glutamine and asparagine, the emitted volatile blend suppressed the growth of <em>F. culmorum</em>, whereas when cultivated in the presence of glycine, glutamine, arginine and lysine the volatile blend suppressed the growth of <em>R. solani</em>. Analysis of the volatile blend composition showed differences between the amino acid treatments. Our findings show that amino acid precursor molecules can stimulate the production of fungistatic volatiles but the sensitivity of the fungal pathogens to these bacterial volatiles varies. This should be considered in future application strategies.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"8 ","pages":"Article 100385"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irrigation water and soil chemistry shape fungal guilds in date palm soils, enhancing pathotroph abundance under saline groundwater irrigation","authors":"Subha Chandran ,&nbsp;Dinesh Sanka Loganathachetti ,&nbsp;Balamurugan Sadaiappan ,&nbsp;Sanjay Swarup ,&nbsp;Sunil Mundra","doi":"10.1016/j.crmicr.2025.100370","DOIUrl":"10.1016/j.crmicr.2025.100370","url":null,"abstract":"<div><div>Saline groundwater irrigation is a predominant practice, especially in date palm (<em>Phoenix dactylifera L</em>.) farms in arid agroecosystems with scarce freshwater resources. Despite its economic importance, the influence of saline groundwater irrigation on bulk soil fungi remains overlooked. This study examined how saline groundwater irrigation affects fungal diversity, community structure, and assembly processes. Bulk soils from date palm farms with distinct irrigation sources (freshwater and saline groundwater), were analysed, and fungal community analyses were done using the internal transcribed spacer 2 (ITS2) sequencing. Soils irrigated with saline groundwater had a lower percentage (27%) of unique operational taxonomic units (OTUs) compared to freshwater (33.3%). Fungal richness negatively correlated with soil pH. Differences observed in overall and guild-specific fungal communities, with irrigation water electrical conductivity (EC) emerging as a pivotal factor distinguishing between the two irrigation sources. Notably, pathotrophs abundance was significant in soils irrigated with saline groundwater. Furthermore, the dominant pathotroph <em>Fusarium</em>, exhibited drift-based assembly process and was observed to be high under saline groundwater irrigation. Our study reveals that groundwater salinity reduces the number of unique OTUs and alters fungal communities at the overall and guild levels. This insight aids agricultural improvement in regions where saline groundwater is a predominant water source.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"8 ","pages":"Article 100370"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Metabolites from Bacillus spp. probiotics as potential treatments for multidrug-resistant pathogens: A comprehensive review","authors":"George Michael Nicolas","doi":"10.1016/j.crmicr.2025.100392","DOIUrl":"10.1016/j.crmicr.2025.100392","url":null,"abstract":"<div><div>The discovery of antibiotics is a significant medical breakthrough, saving millions of lives. However, the widespread misuse and overuse of antibiotics led to the development of antimicrobial resistance. Spore-forming probiotics from <em>Bacillus</em> spp. show great interest as antimicrobial agents through the production of strain-specific bioactive secondary metabolites. This review summarizes the broad-spectrum antimicrobial activities of <em>Bacillus</em> spp. secondary metabolite groups and their reported mechanisms of action, underscoring the urgency in developing novel antimicrobial drugs.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"8 ","pages":"Article 100392"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Canine-derived Weissella confusa ZJUIDS-D034 and Enterococcus faecalis ZJUIDS-D016 combat aging by regulating gut microbiota","authors":"Nan Chen ,&nbsp;Zexu Yu ,&nbsp;Xuan Ji ,&nbsp;Siyi Zhang ,&nbsp;Chongwei Yu ,&nbsp;Teresa G. Valencak ,&nbsp;Fushan Shi ,&nbsp;Daxi Ren","doi":"10.1016/j.crmicr.2025.100381","DOIUrl":"10.1016/j.crmicr.2025.100381","url":null,"abstract":"<div><div>Old age raises the susceptibility of age-related disease in domestic dogs. Discovering effective anti-aging interventions is key for mitigating age-related disease and conserving “healthspan” in pet dogs. In this study, 2 bacterial strains were isolated from canine feces. After screening and identifying the strains, <em>Weissella confusa</em> ZJUIDS-D034 and <em>Enterococcus faecalis</em> ZJUIDS-D016 were chosen to intervene during <em><span>d</span>-</em>galactose-induced senescence in mice. We found that administering <em>Weissella confusa</em> ZJUIDS-D034 and <em>Enterococcus faecalis</em> ZJUIDS-D016 improved the aging phenotype of mice, including an increase in antioxidant activity, a decrease in pro-inflammatory cytokines, and the restoration of intestinal and liver tissue damage. In addition, <em>Weissella confusa</em> ZJUIDS-D034 and <em>Enterococcus faecalis</em> ZJUIDS-D016 lead to changes in the structure of intestinal microbiota in aging mice. Specifically, there was a decrease in the abundance of the <em>Cyanobacteria</em> and an increase in the abundance of <em>Akkermansia</em> and <em>Lactobacillus</em>. More importantly, there was a significant increase in acetic acid, a short-chain fatty acid, due to intervention with the 2 strains. This increase might be attributed to higher <em>Akkermansia</em>. We show that the modulation of gut microbiota and metabolism in aging mice may be a promising strategy through which <em>Weissella confusa</em> ZJUIDS-D034 and <em>Enterococcus faecalis</em> ZJUIDS-D016 might exert their anti-aging effects.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"8 ","pages":"Article 100381"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}