Current Research in Microbial Sciences最新文献

{"title":"Process optimization and evaluation of quality properties of natto with co-culture of Bacillus subtilis natto and Limosilactobacillus fermentum","authors":"Yi-Ni Ma ,&nbsp;Xun Xu ,&nbsp;Lai-Feng Chen ,&nbsp;Jin-Ping Zhou ,&nbsp;Zhen-Hui Cao ,&nbsp;Qiu-Ye Lin","doi":"10.1016/j.crmicr.2025.100347","DOIUrl":"10.1016/j.crmicr.2025.100347","url":null,"abstract":"<div><div>The present study aimed to optimize the processing technology of natto fermented with <em>Bacillus subtilis</em> natto and <em>Limosilactobacillus fermentum</em> 2–2 and its effect on quality characteristics as well as volatile compounds. The results of single-factor tests and response surface methodology (RSM) showed that the optimal fermentation conditions of natto were L. <em>fermentum</em> inoculation amount of 0.3 %, fermentation temperature at 39 °C, fermentation time of 48 h, and after-ripening time of 24 h. Compared with natto control with <em>B. subtilis</em> natto only, natto co-cultured with <em>B. subtilis</em> natto and L. <em>fermentum</em> 2–2 showed higher scavenging ability of 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and greater nattokinase activity. Volatomics analysis revealed that 71 differential volatile compounds were identified with 23 up-regulated and 48 down-regulated. Especially, co-fermentation of <em>B. subtilis</em> natto and L. <em>fermentum</em> 2–2 increased generation of alcohols, ketones and esters while reduced pyrazines formation. The above results indicate that co-culture of <em>B. subtilis</em> natto and L. <em>fermentum</em> can enhance the antioxidant and nattokinase activity and modify the volatile profile in natto and have the potential for application as the mixed starter in natto production.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"8 ","pages":"Article 100347"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First whole genome report of Mangrovibacter phragmitis PSU-3885–11 isolated from a patient in Thailand","authors":"Nattarika Chaichana ,&nbsp;Thunchanok Yaikhan ,&nbsp;Mingkwan Yingkajorn ,&nbsp;Nonthawat Thepsimanon ,&nbsp;Sirikan Suwannasin ,&nbsp;Kamonnut Singkhamanan ,&nbsp;Sarunyou Chusri ,&nbsp;Rattanaruji Pomwised ,&nbsp;Monwadee Wonglapsuwan ,&nbsp;Komwit Surachat","doi":"10.1016/j.crmicr.2025.100350","DOIUrl":"10.1016/j.crmicr.2025.100350","url":null,"abstract":"<div><div><em>Mangrovibacter phragmitis</em> is a Gram-negative bacterium typically found in plant roots that supports nitrogen fixation in nutrient-poor environments such as mangrove ecosystems. Although primarily found in environmental niches, an unusual case in Thailand of <em>M. phragmitis</em> strain PSU-3885–11 isolated from the sputum of a 29-year-old female patient with spinal tuberculosis. This isolate was initially misidentified as part of the <em>Enterobacter cloacae</em> complex (ECC) by MALDI-TOF. However, WGS subsequently confirmed its correct identity as <em>M. phragmitis</em>. The genome contains 4,651 coding sequences, along with 72 tRNA genes and 1 tmRNA. Moreover, comparative genomic analysis showed 99.32 % average nucleotide identity (ANI) similar to <em>M. phragmitis</em> MP23, and several antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) were identified in the PSU-3885–11 genome which may contribute to its ability to survive in diverse environments, including human hosts. The PSU-3885–11 displayed resistance to beta-lactam antibiotics such as ampicillin and cefotaxime, while remaining sensitive to a wide range of other antibiotics. Key virulence genes including <em>ompA, hcp/tssD,</em> and <em>rpoS</em>, were identified which may play a role in its persistence in human hosts as an opportunistic pathogen. The presence of ribosomally synthesized and post-translationally modified peptides (RiPPs) and bacteriocins indicates the antimicrobial properties that may provide a competitive advantage in both environmental and clinical settings of this strain. Therefore, this study provides valuable insights into the genomic features, antibiotic resistance, and potential pathogenicity of <em>M. phragmitis</em> PSU-3885–11. The findings also emphasize the importance of continued surveillance and genomic analysis of environmental bacteria that may emerge as opportunistic pathogens in human infections.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"8 ","pages":"Article 100350"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards a comprehensive view of wetland benthic communities","authors":"Clélia Duran ,&nbsp;Christine Dupuy ,&nbsp;Hélène Agogué ,&nbsp;Robert Duran ,&nbsp;Cristiana Cravo-Laureau","doi":"10.1016/j.crmicr.2025.100391","DOIUrl":"10.1016/j.crmicr.2025.100391","url":null,"abstract":"<div><div>Benthic prokaryotic communities, utmost important for wetlands and marine environments functioning, are influenced by physical-chemical parameters and interactions with other communities, especially micro-eukaryotes and meiofauna. Thus, a holistic view of the benthic community is necessary to fully understand their organization and functioning. This study assesses the implementation of a comprehensive view, using mock communities and environmental samples. A DNA extraction strategy combining two procedures is proposed: one to obtain DNA from micro-organisms, using 0.25 g of sediment, and the other from meiofauna, using 0.25 g of sieving refluxes from 5 g of sediment. Three conditions were considered to create mock communities: (i) varying eukaryotes’ abundance, (ii) adding meiofauna from salted or freshwater wetlands, and (iii) including or not a sediment matrix. Most organisms composing the mock communities were detected, except a filamentous cyanobacteria. All mock communities showed similar composition indicating that sediment did not affect the DNA extraction. This result also demonstrated that sieving, necessary to enrich meiofauna from sediment, does not significantly affect any of the communities. For the environmental samples investigated, most of the taxa usually described in the literature were retrieved in the salted, brackish and freshwater marshes sediment. The proposed approach was successful in analysing organisms from the three domains of life in a unique environmental sample, providing a holistic view of the benthic community. Furthermore, the significant differences observed between samples from the three different marshes, indicated that our approach can be used for conducting successful ecological studies, especially useful for understanding benthic communities’ interactions.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"8 ","pages":"Article 100391"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Participation of gut microbiota and bacterial translocation in chronic systemic inflammation in recently diagnosed rheumatoid arthritis patients","authors":"Catherine Dunyach-Remy ,&nbsp;Cassandra Pouget ,&nbsp;Yves-Marie Pers ,&nbsp;Cécile Gaujoux-Viala ,&nbsp;Christophe Demattei ,&nbsp;Florian Salipante ,&nbsp;Lucia Grenga ,&nbsp;Jean Armengaud ,&nbsp;Jean-Philippe Lavigne ,&nbsp;Christian Jorgensen","doi":"10.1016/j.crmicr.2025.100366","DOIUrl":"10.1016/j.crmicr.2025.100366","url":null,"abstract":"<div><div>The objective of this study was to investigate the link between gut microbiota (GM) dysbiosis, gut inflammation, and bacterial translocation (BT) in recently diagnosed rheumatoid arthritis (RA). This case-control, observational study prospectively recruited recently diagnosed (&lt;12 months) RA patients and age-matched healthy controls (HC) from two French hospitals between July 2014 to March 2018. The primary objective was to investigate GM composition in each group using 16S rRNA sequencing and metaproteomics approaches. Three plasmatic BT markers (sCD14, LPS-binding protein, and number of 16S rRNA gene copies) and one intestinal permeability marker (I-FABP) were quantified in blood samples.</div><div>Twenty-five were included in each group, and 50 stools and blood samples were analyzed. 16S rRNA gene analysis showed an decrease in <em>Coprococcus</em> in RA patients after Body Mass Index and HLA status. Circulating bacterial DNA (number of copies of the 16S rRNA gene) and plasmatic I-FABP were higher in RA patients compared to HCs (<em>p</em> &lt; 0.01), indicating increased BT and intestinal permeability in these patients. Metaproteomics from stool samples highlighted an increased host humoral immune response in RA, with elevated levels of inflammatory proteins (azurocidin, cathepsin G, neutrophil defensing 1). Gut inflammation may contribute to increased intestinal permeability, leading to BT into the systemic circulation and thus chronic inflammation.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"8 ","pages":"Article 100366"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in research on gut microbiota and allergic diseases in children","authors":"Heng Ke,&nbsp;Hongbing Yao,&nbsp;Ping Wei","doi":"10.1016/j.crmicr.2025.100362","DOIUrl":"10.1016/j.crmicr.2025.100362","url":null,"abstract":"<div><div>Epidemiological studies indicate a rising prevalence of allergic diseases, now recognized as a major global public health concern. In children, the progression of these diseases often follows the \"atopic march,\" beginning with eczema, followed by food allergies, allergic rhinitis, and asthma. Recent research has linked gut microbiota dysbiosis to the development of allergic diseases in children. The gut microbiota, a crucial component of human health, plays a vital role in maintaining overall well-being, highlighting its potential in preventing and modifying the course of allergic diseases. This review examines the relationship between childhood allergic diseases and gut microbiota, drawing on the latest evidence. We first elaborated the concepts of allergic diseases and gut microbiota, followed by a discussion of the developmental trajectory of the gut microbiota in healthy children. This review further explored the richness, diversity, and composition of the gut microbiota, as well as specific microbial taxa associated with allergic disease. Lastly, we discussed the current status and future potential of probiotic interventions in managing pediatric allergic diseases.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"8 ","pages":"Article 100362"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidrug resistant Acinetobacter baumannii: A study on its pathogenesis and therapeutics","authors":"Hridesh Mukhopadhyay ,&nbsp;Arnab Bairagi ,&nbsp;Anushka Mukherjee ,&nbsp;Aman Kumar Prasad ,&nbsp;Arjama Dhar Roy ,&nbsp;Aditi Nayak","doi":"10.1016/j.crmicr.2024.100331","DOIUrl":"10.1016/j.crmicr.2024.100331","url":null,"abstract":"<div><div>The overuse of antibiotics has led to the global dissemination of <em>Acinetobacter baumannii</em>, an increasingly challenging nosocomial pathogen. This review explores the medical significance along with the diverse resistance ability of <em>A. baumannii</em>. Intensive care units (ICUs) serve as a breeding ground for <em>A. baumannii</em>, as these settings harbour vulnerable patients and facilitate the spread of opportunistic microorganisms. <em>A. baumannii</em> belongs to the ESKAPE group of bacterial pathogens that are major contributors to antibiotic-resistant infections. The pathogenic nature of <em>A. baumannii</em> is particularly evident in seriously ill patients, causing pneumonia, wound infections, and other healthcare-associated infections. Historically considered benign, <em>A. baumannii</em> is a global threat due to its propensity for rapid acquisition of multidrug resistance phenotypes. The genus <em>Acinetobacter</em> was formally recognized in 1968 following a comprehensive survey by Baumann <em>et al</em>., highlighting the relationship between previously identified species and consolidating them under the name <em>Acinetobacter. A. baumannii</em> is characterized by its Gram-negative nature, dependence on oxygen, positive catalase activity, lack of oxidase activity, inability to ferment sugars, and non-motility. The DNA G+C content of <em>Acinetobacter</em> species falls within a specific range. For diagnostic purposes, <em>A. baumannii</em> can be cultured on specific agar media, producing distinct colonies. The genus <em>Acinetobacter</em> comprises numerous species those are associated with bloodstream infections with high mortality rates. Therefore, <em>A. baumannii</em> poses a significant challenge to global healthcare due to its multidrug resistance and ability to cause various infections. A comprehensive understanding of the mechanisms underlying its resistance acquisition and pathogenicity is essential for combating this healthcare-associated pathogen effectively.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"8 ","pages":"Article 100331"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reflections on microbial genetic resources in agricultural systems","authors":"Iván Pável Moreno-Espíndola,&nbsp;Alonso Gutiérrez-Navarro,&nbsp;Diana Carolina Franco-Vásquez,&nbsp;Daniel Vega-Martínez","doi":"10.1016/j.crmicr.2024.100337","DOIUrl":"10.1016/j.crmicr.2024.100337","url":null,"abstract":"<div><div>This paper reflects on the use of microbial genetic resources in the context of agricultural systems. The benefits of harnessing the diversity of these resources in any agricultural system are highlighted, as well as the importance of knowing and preserving native agrobiodiversity, which is deemed an essential resource for Latin America. In this region, harmful effects of irrational use of agrochemicals and monocultures on the environment, economy, and health have been brought to light. In view of the growing awareness and global interest in the development of bioinputs, rational biodiversity use, environmental crisis, cost of conventional synthetic inputs, and the right to safe and quality food, agriculture requires new tools and effective strategies in its practice. Microbial genetic resources are a potential source of relevant and suitable inputs for this purpose. Using the bibliometric technique of co-occurrence of terms with the VOSviewer tool, an analysis of 60 articles published between 2020 and 2024, collected from databases such as Scopus and Web of Science, was performed. An interest in microbial resources and their potential application in plant nutrition, production of growth regulators, defenses against pests and diseases, and tolerance to limiting environmental conditions can be appreciated. However, elucidating their complex ecological dynamics is necessary to understand them in real production contexts, thus allowing the allocation of relevant technological packages and the fair management of their use and potential benefits.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"8 ","pages":"Article 100337"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental characteristics and weather impact yeast populations and their dynamics in spontaneous fermentations","authors":"Beatrice Valentini,&nbsp;Noemi Gatti,&nbsp;Simone Bossi,&nbsp;Gianpiero Vigani,&nbsp;Irene Stefanini","doi":"10.1016/j.crmicr.2025.100410","DOIUrl":"10.1016/j.crmicr.2025.100410","url":null,"abstract":"<div><div>Winemaking is influenced by many factors, from the vineyard to the fermentation process. While traditional approaches have focused on vineyard treatments and controlled fermentations to ensure a stable product, global warming has made it necessary to reassess the effects of these factors on winemaking. This study aimed to evaluate the impact of vintage, management, and environmental settings on the composition of yeast populations driving grape spontaneous fermentations and defining the characteristics of the final product. Our results emphasize how climate change and the vineyard’s yeast populations influence fermentation, showing that while the vintage plays a key role in grape composition, it s not the sole determinant of fermentation. The geographical location of the vineyard, alongside the management practices and vintage, shapes the composition and dynamics of yeast populations. Specific vineyard conditions sometimes lead to stable and unique yeast populations. Furthermore, the grape origin affects both the yeast population and the wine’s volatile compounds, with certain yeast species, like <em>Saccharomyces cerevisiae</em>, being linked to specific environmental features. While vintage and climate change impact a smaller portion of the yeast population, the environment remains a significant influence. As fermentation progresses, the yeast populations retain vineyard-specific characteristics, underlining the strong connection between yeast dynamics and environmental factors. Understanding these interactions is crucial for adapting to global warming and optimizing wine fermentation processes. It will help improve wine quality, innovation, and specific wine characteristics through better management of microbial communities in the grape-wine ecosystem.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"9 ","pages":"Article 100410"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradation of sodium selenite by a highly tolerant strain Rhodococcus qingshengii PM1: Biochemical characterization and comparative genome analysis","authors":"Zhiyong Wang ,&nbsp;Xue Hou ,&nbsp;Zhikang Guo ,&nbsp;Xue Lei ,&nbsp;Mu Peng","doi":"10.1016/j.crmicr.2025.100426","DOIUrl":"10.1016/j.crmicr.2025.100426","url":null,"abstract":"<div><h3>Background</h3><div><em>Rhodococcus</em> is an important genus of soil bacteria known for its metabolic diversity and environmental adaptability under harsh and contaminated conditions. However, few studies have reported on the selenium metabolism of <em>Rhodococcus</em> species.</div></div><div><h3>Results</h3><div>Here, we isolated a highly selenite-resistance strain PM1 (up to 100 mM) from a selenium-rich mine in Enshi City. This strain reduced 50 mM sodium selenite by 99 % within 72 h. SEM and XPS revealed that PM1 reduced selenite to selenium nanorods (SeNRs). Phylogenetic analysis identified PM1 as <em>R. qingshengii</em>. The whole genome of strain PM1 was sequenced, and a comparative genome analysis of strain PM1with 64 other genomes of <em>Rhodococcus</em> was performed. Whole genome sequencing identified a total of 97 heavy metal resistance genes in strain PM1. Comparative genomics revealed that <em>Rhodococcus</em> species possess an open pan-genome, indicating adaptability to diverse environments. Genomic analysis revealed a total of 96 putative selenite-reducing proteins in strain PM1. Four gene clusters, involved in the pentose phosphate pathway, iron-sulfur cluster assembly, sulfate reductase cluster, and sulfate transport complex, showed high conservation of sequence identity within these species.</div></div><div><h3>Conclusions</h3><div>To our knowledge, this research enhances our understanding of high selenite reduction in strain PM1 at genomic level and elucidates the biotechnological applications of selenite-reducing bacteria in environmental remediation.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"9 ","pages":"Article 100426"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing prostate cancer treatment: the role of fecal microbiota transplantation as an adjuvant therapy","authors":"Rasoul Ebrahimi ,&nbsp;Shahrzad Shahrokhi Nejad ,&nbsp;Mehra Fekri ,&nbsp;Seyed Aria Nejadghaderi","doi":"10.1016/j.crmicr.2025.100420","DOIUrl":"10.1016/j.crmicr.2025.100420","url":null,"abstract":"<div><div>Prostate cancer (PCa) is a major cause of cancer-related deaths worldwide. While current treatments such as surveillance, surgery, and radiation are effective, they have their limitations. These can include patient incompliance due to side effects or resistance to hormonal changes, highlighting the need for alternative approaches. Human microbiota, a complex and dynamic host, plays a significant role in the homeostasis and is associated with several diseases or cancers in cases of dysregulation and dysbiosis. Research on fecal microbiota profiling and its association with certain cancers has opened new possibilities for preventing and managing tumor progression. One such possibility is fecal microbial transplantation (FMT). Studies show that different composition of urinary microbiota is found in various urinary tract diseases. Gut microbiota can regulate immune response against tumors; therefore, FMT may help modulate gut microbiota in a way that potentially enhances responses to immune checkpoint inhibitors, as suggested by emerging evidence in other cancers, though this needs further validation in PCa. Nevertheless, long-term complications and the safety of FMT are still questioned. We reviewed the roles of gut microbiota in PCa and suggested FMT as a potential tool in the treatment of PCa, which needs further investigations.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"9 ","pages":"Article 100420"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}