Medicine in Novel Technology and Devices最新文献

{"title":"Cover","authors":"","doi":"10.1016/S2590-0935(24)00045-6","DOIUrl":"10.1016/S2590-0935(24)00045-6","url":null,"abstract":"","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"23 ","pages":"Article 100329"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000456/pdfft?md5=5ee2e9eea66ecac35b597c906e18f29f&pid=1-s2.0-S2590093524000456-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of type I and II collagen in osteochondral tissue engineering: Respective features and future perspectives","authors":"Ruoyu Huang,&nbsp;Xiaolian Niu,&nbsp;Xueying Li,&nbsp;Xiaoming Li","doi":"10.1016/j.medntd.2024.100328","DOIUrl":"10.1016/j.medntd.2024.100328","url":null,"abstract":"<div><p>At present, osteoarthritis stands as one of the most prevalent degenerative musculoskeletal diseases globally. The inherent lack of self-healing capacity in articular cartilage presents a considerable obstacle in treating osteoarthritis. Tissue engineering emerged as a promising strategy for the regeneration of osteochondral defects. Collagen, a primary component of bone and cartilage, stands out as a widely utilized natural material in osteochondral tissue engineering. Among various collagen types, Type I and type II collagen are notably prominent in this field. This review initially summarizes the advantageous and disadvantageous properties of type I/II collagen in osteochondral tissue engineering, proceeds to introduce their applications in this context, and concludes with a prospective outlook on the future development of type I/II collagen's applications.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100328"},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000444/pdfft?md5=f1a3f6bb134e000bc445dff049786a89&pid=1-s2.0-S2590093524000444-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142149028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatocellular carcinoma imaging: Exploring traditional techniques and emerging innovations for early intervention","authors":"Hariharan Thirumalai Vengateswaran ,&nbsp;Mohammad Habeeb ,&nbsp;Huay Woon You ,&nbsp;Kiran Balasaheb Aher ,&nbsp;Girija Balasaheb Bhavar ,&nbsp;Govind Sarangdhar Asane","doi":"10.1016/j.medntd.2024.100327","DOIUrl":"10.1016/j.medntd.2024.100327","url":null,"abstract":"<div><p>Hepatocellular carcinoma (HCC) continues to be a diagnostic and therapeutic challenge for healthcare systems around the world in addition to being a significant contributor to oncologic mortality. To improve the standard of life and the survival of patients, early diagnosis of the condition and subsequent appropriate treatment are essential. Hepatocellular carcinoma (HCC) observation, early detection, diagnosis, and follow-up all depend heavily on imaging modalities. They provide valuable information about the characteristics of HCC nodules, aiding in non-invasive diagnosis and staging. Imaging has evolved beyond simply confirming a suspected diagnosis in the management of hepatocellular carcinoma (HCC). Several traditional imaging modalities, including PET/CT, MRI, MR elastography, ultrasound (US), and endoscopy, along with next-generation imaging modalities such as photoacoustic imaging, and Cerenkov luminescence with the utilization of contrasting agents further enhance their diagnostic capabilities in HCC. The selection of the most appropriate imaging modality and contrasting agent depends on various factors, including the clinical scenario, patient characteristics, and availability of resources. In addition to these advancements, artificial intelligence (AI) has developed as a valuable tool in radiology for the management of HCC. In this review, we highlighted the most important imaging techniques for managing patients with a high risk of HCC.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100327"},"PeriodicalIF":0.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000432/pdfft?md5=96a2ed1026601e6e818f337c6c0f729b&pid=1-s2.0-S2590093524000432-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of microneedle arrays in cosmetics: Promises, advances, and challenges","authors":"Amarjitsing Rajput ,&nbsp;Anuradha Patil ,&nbsp;Priyanka Kandhare ,&nbsp;Atmaram Pawar","doi":"10.1016/j.medntd.2024.100325","DOIUrl":"10.1016/j.medntd.2024.100325","url":null,"abstract":"<div><p>Microneedle technology involves skin puncturing and has emerged as an innovative approach for drug delivery and cosmetic applications. MNs offer advantages over traditional injections, such as reduced pain, infection risks, and improved control of drug delivery. Cosmetic products aim to alter or enhance the appearance of the human body, while transdermal drug delivery involves administering drugs via the skin for local or systemic treatment. The use of MNs in combination with cosmetics has shown promise in improving nutrient delivery, skin healing, and penetration of cosmeceuticals. The development of microfabrication technologies has allowed the production of MNs in various sizes, shapes, and materials mainly used for loading cosmetic compounds. Clinical trial studies have explored MNs' clinical potential in drug delivery, diagnosis and administration of cosmeceuticals. The review highlights the superior efficacy of dissolving MNs in enhancing transdermal drug delivery compared to traditional methods, which are currently used by several researchers and evidenced by multiple clinical studies. The current review article compilation encompasses the microneedle in cosmetic delivery and its applications in managing various skin diseases. It differs from earlier available reviews on MNs in several aspects, novelty lies as it describes microneedle applications in cosmetics. It also focuses on recent technologies for transdermal delivery like iontophoresis, sonophoresis, magnetophoresis, electroporation, laser ablation, and jet injectors. It mainly covers the role of MNs in managing various diseases by covering case studies. It also covers challenges, commercial successes, safety measures, regulatory facts, and future perspectives of microneedles in cosmetic delivery. This article highlights the potential of MNs to revolutionize transdermal drug delivery, which will benefit various industries and patients worldwide. Furthermore, this article emphasizes the potential impact of ongoing research and commercialization of MNs.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100325"},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000419/pdfft?md5=d8f7255a0df65c916af814ce3437bb07&pid=1-s2.0-S2590093524000419-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swallowing hydrodynamics visualization and aspiration quantification in a patient-specific pharyngolaryngeal model with varying epiglottis inversions","authors":"Amr Seifelnasr ,&nbsp;Chen Sun ,&nbsp;Peng Ding ,&nbsp;Xiuhua April Si ,&nbsp;Jinxiang Xi","doi":"10.1016/j.medntd.2024.100326","DOIUrl":"10.1016/j.medntd.2024.100326","url":null,"abstract":"<div><p>Impaired swallowing, or dysphagia, significantly affects patients' well-being and health. Nearly half of the patients with head and neck cancers experience dysphagia or aspiration following radiation therapy or surgery. However, current dysphagia management approaches are primarily symptom-based rather than etiology-specific, owing to a lack of clear understanding of aspiration mechanisms. This study aimed to understand the mechanisms of aspiration in an anatomically accurate pharyngolaryngeal model at different epiglottis angles. A biomechanical swallowing model was developed using transparent casts, and liquid flow dynamics were visualized using fluorescent dye from side and back views. Two liquids and two dispensing conditions were evaluated for their roles in aspiration. The results demonstrated distinct flow dynamics between water and a 1 ​% w/v methylcellulose aqueous solution and, to a lesser extent, between fast and slow dispensing for the same liquid. Three frequent aspiration sites were identified, including the interarytenoid notch, the cuneiform tubercular recess, and the vallecula, corresponding to aspiration mechanisms of notch overflow, recess overflow, and creeping flow, respectively. The angle of the epiglottis influenced flow dynamics in at least three ways: by facilitating gravity-assisted fluid movement, redistributing flow through the gap between the epiglottis tip and pharyngeal wall, and affecting creeping flow via the angle between the epiglottis base and hypopharynx. Slow dispensing of water to the anterior oropharynx resulted in a significantly high aspiration rate with a downward tilted epiglottis due to concurrent tubercle-recess overflow and vallecular creeping flow. The biomechanical model can serve as a testing platform for better understanding aspiration mechanisms and developing etiology-based strategies before and after treatments for head and neck cancers.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100326"},"PeriodicalIF":0.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000420/pdfft?md5=ebaf8d0111da407483d587fa78ea4ea5&pid=1-s2.0-S2590093524000420-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142095545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical testing of immunotoxicity for animal-derived dermal materials","authors":"Huan Lian,&nbsp;Yu Liu,&nbsp;Han Wang,&nbsp;Jianxia Xu,&nbsp;Qianqian Han","doi":"10.1016/j.medntd.2024.100323","DOIUrl":"10.1016/j.medntd.2024.100323","url":null,"abstract":"<div><p>Animal derived materials have been widely used in biomedical products owing to their good biocompatibility and appropriate mechanical properties. It is crucial to evaluate the immunotoxicity of such materials in preclinical testing to prevent severe immune responses in patients. In this study, a pipeline of immunotoxicity tests was established to evaluate animal-derived materials before de-cellularization and final products. This pipeline contains a serial of animal tests on BALB/c mice and an <em>in vitro</em> quantification test for a-Gal antigen. It is well-recognized that the interaction between materials and patients profoundly alters immune responses, thus, a comprehensive dataset including body weight, immune organ coefficient, histopathology, peripheral hematology, serum immunoglobulin level, spleen lymphocyte proliferation rate, and their subpopulation was created and analyzed using the SPSS tool. These results clearly suggested that the de-cellularized materials possessed better biocompatibility, in addition, the a-Gal antigen content was effectively decreased by 96.0 ​% after de-cellularization. Thus, this study confirmed that this multi-step enzymatic de-cellularization treatment is a potent method to reduce the immunotoxicity of animal-derived biomaterials. Moreover, the experimental pipeline will likely be transferable to other biomedical materials and products.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"23 ","pages":"Article 100323"},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000390/pdfft?md5=58975ddce0c4dde7199011713c2ea313&pid=1-s2.0-S2590093524000390-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141993099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A time-synchronized multimodal monitoring system for general anesthesia","authors":"Zhenhu Liang ,&nbsp;Guanwei Geng ,&nbsp;Qifeng Song ,&nbsp;Mengmeng Tang","doi":"10.1016/j.medntd.2024.100324","DOIUrl":"10.1016/j.medntd.2024.100324","url":null,"abstract":"<div><p>In clinical settings, different kinds of patient monitoring systems and depth of anesthesia monitoring (DoA) systems have been widely used to assess the depth of sedation and patient's state. However, all these monitoring systems are independent of each other. To date, no monitoring system has focused on the synchronized neural activities, cerebral metabolism, autonomic nervous system, and drug effects on the brain, as well as their interactions between neural activities and cerebral metabolism (i.e., neurovascular coupling), and between brain and heart (i.e., brain-heart coupling). In this study, we developed a time-synchronized multimodal monitoring system (TSMMS) that integrates electroencephalogram (EEG), near-infrared spectroscopy (NIRS), and standard physiological monitors (electrocardiograph, blood pressure, oxygen saturation) to provide a comprehensive view of the patient's physiological state during surgery. The coherence and Granger causality (GC) methods were used to quantify the neurovascular coupling and brain-heart coupling. The response surface model was used to estimate the combined propofol-remifentanil drug effect on the brain. TSMMS integrates data from various devices for a comprehensive analysis of vital signs. It enhances anesthesia monitoring through detailed EEG features, neurovascular, and brain-heart coupling indicators. Additionally, a response surface model estimates the combined effects of propofol and remifentanil, aiding anesthesiologists in drug administration. In conclusion, TSMMS provides a new tool for studying the coupling mechanism among neural activities, cerebral metabolism, and autonomic nervous system during general anesthesia.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"23 ","pages":"Article 100324"},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000407/pdfft?md5=452bb2dd86f1c20ab46d691c255d0d13&pid=1-s2.0-S2590093524000407-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141979477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum regarding updating Declaration of Competing Interest and animal studies statements in previously published articles","authors":"","doi":"10.1016/j.medntd.2024.100306","DOIUrl":"10.1016/j.medntd.2024.100306","url":null,"abstract":"","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"23 ","pages":"Article 100306"},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000225/pdfft?md5=045052dedc882e34445c1894735b9441&pid=1-s2.0-S2590093524000225-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141729624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent applications and molecular mechanisms of hyaluronic acid in skin aging and wound healing","authors":"Lin Shang ,&nbsp;Man Li ,&nbsp;Anjian Xu ,&nbsp;Fenglin Zhuo","doi":"10.1016/j.medntd.2024.100320","DOIUrl":"10.1016/j.medntd.2024.100320","url":null,"abstract":"<div><p>Skin aging and wound healing have always been significant topics in the skin field. Hyaluronic acid (HA), a natural glycosaminoglycan (GAG) presenting in the extracellular matrix (ECM), is extensively applied in the fields of anti-aging therapeutics and wound repair due to its unique physicochemical and biological properties. HA is indispensable in the regulation of diverse biological processes such as cellular proliferation, differentiation, migration, signaling, inflammatory responses, angiogenesis, and tissue regeneration. Consequently, HA-based formulations, including creams, gels, serums, and dermal fillers, are instrumental in combating wrinkles, enhancing skin hydration, correcting tear trough deformity, and restoring facial volume. Additionally, the inherent biocompatibility and high biodegradability of HA facilitates its chemical modification, rendering it an ideal material for wound healing and tissue regeneration. This review summarizes the recent advances and applications of the molecular mechanisms of HA and its derivatives in the field of anti-aging and wound healing; and discusses the prospects and challenges of HA-based compounds in tissue repair and skin regeneration.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"23 ","pages":"Article 100320"},"PeriodicalIF":0.0,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000365/pdfft?md5=158cc6c6f2a015af5f386adc42733e12&pid=1-s2.0-S2590093524000365-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141715858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NO transport characteristics in microcirculation and its implications in the assessment of microvascular dysfunction in type 2 diabetes mellitus","authors":"Ying He ,&nbsp;Yongtao Liu ,&nbsp;Lili Long ,&nbsp;Yajie Wei ,&nbsp;Yunxia Lu","doi":"10.1016/j.medntd.2024.100321","DOIUrl":"10.1016/j.medntd.2024.100321","url":null,"abstract":"<div><p>Diabetes mellitus is a metabolic disorder syndrome caused by various pathogenic factors leading to imbalance of active substance secretion and endothelial dysfunction, causing macro and micro vascular complications. As the most important signal transduction molecule released by endothelium, NO participates in various physiological processes of microcirculation and plays an important role in vascular relaxation regulation. Extensive studies focus on the investigation of the analysis of NO transport in microvessels, RBC motion and its influence on NO transport since they are of extremely importance for understanding the mechanisms of vessel autoregulation and microcirculation lesion. NO transport characteristics are closely associated with hemorheology, hemodynamics and microvascular structure. Nevertheless, up to date, there are limited reports on NO transport characteristics in diabetic mellitus. The purpose of this review is to summarize the current advances in the investigation of NO transport characteristics from cellular to vascular level, which can provide effective ideas for the early diagnosis of vascular complications in diabetes.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"23 ","pages":"Article 100321"},"PeriodicalIF":0.0,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000377/pdfft?md5=744a274c8e30955c65ad77c5af700a74&pid=1-s2.0-S2590093524000377-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141691876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}