Medicine in Novel Technology and Devices最新文献_第3页

Emerging strategies and multifunctional applications of nanomaterials in modern nanomedicine 纳米材料在现代纳米医学中的新兴策略和多功能应用

Medicine in Novel Technology and Devices Pub Date : 2025-12-01 Epub Date: 2025-09-08 DOI: 10.1016/j.medntd.2025.100400

Indhumathi Kamaraj PhD , Santhosh Kamaraj PhD , Ganesan Shanmugam PhD

{"title":"Emerging strategies and multifunctional applications of nanomaterials in modern nanomedicine","authors":"Indhumathi Kamaraj PhD , Santhosh Kamaraj PhD , Ganesan Shanmugam PhD","doi":"10.1016/j.medntd.2025.100400","DOIUrl":"10.1016/j.medntd.2025.100400","url":null,"abstract":"<div><div>The growing complexity of diseases, alongside the limitations of conventional therapies and the rise of multidrug resistance, underscores the pressing need for innovative treatment paradigms. Herein, we highlight the transformative potential of nanomaterials in modern nanomedicine, focusing on their ability to enable precise, targeted, and multifunctional therapeutic interventions. However, despite their promise, clinical translation remains constrained by several challenges, including immune clearance, systemic toxicity, scalability and a lack of long-term safety data. This review systematically presents emerging strategies that are redefining nanomaterial applications in medicine. These include surface functionalization strategies to enhance targeting specificity, hybrid nanomaterial systems for combined therapeutic and diagnostic (theranostic) functions, and stimuli-responsive strategies for controlled, site-specific drug release. We further examine biomimetic strategies that enable immune evasion by mimicking natural cellular membranes, and scaffold-based approaches that support tissue engineering and regenerative medicine. In the context of oncology, we explore strategies to overcome multidrug resistance through the co-delivery of chemotherapeutics and gene modulators. Finally, we emphasize the role of artificial intelligence (AI)-driven strategies in optimizing nanomaterial design, facilitating high-throughput screening, and predicting biological interactions. Collectively, these advancements offer a robust framework for developing next-generation nanotherapeutics that align with the goals of personalized medicine by improving precision, safety, and clinical efficacy.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"28 ","pages":"Article 100400"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145046545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of acupuncture on pyroptosis pathways after spinal cord injury 针刺对脊髓损伤后焦亡通路的影响

Medicine in Novel Technology and Devices Pub Date : 2025-12-01 Epub Date: 2025-11-13 DOI: 10.1016/j.medntd.2025.100414

Hui Li , Jiayi Zhuang , Xiaobin Sun , Zhe Wei

{"title":"Effect of acupuncture on pyroptosis pathways after spinal cord injury","authors":"Hui Li , Jiayi Zhuang , Xiaobin Sun , Zhe Wei","doi":"10.1016/j.medntd.2025.100414","DOIUrl":"10.1016/j.medntd.2025.100414","url":null,"abstract":"<div><div>Spinal cord injury (SCI) triggers caspase-dependent pyroptosis, amplifying neuroinflammation and secondary damage. Electroacupuncture (EA), a clinically validated rehabilitative intervention, mitigates SCI by targeting pyroptosis-specific mechanisms. Mechanistically, EA inhibits NLRP3 inflammasome assembly and reduces ASC speck formation, thereby suppressing caspase-1 activation. This attenuates gasdermin D (GSDMD) cleavage, pore formation, and IL-1β/IL-18 maturation in microglia and macrophages. Furthermore, EA downregulates cytidine monophosphate kinase 2 (CMPK2) and upregulates calcitonin gene-related peptide (CGRP), disrupting pyroptotic signaling. Evidence from rodent models confirms that EA at spinal Jiaji (EX-B2) or Du meridian acupoints modulates microglial activation and NLRP3/GSDMD-N expression, reducing neuronal pyroptosis and improving motor recovery. While EA demonstrates therapeutic promise via pyroptosis regulation, further mechanistic studies are warranted to define its interactions with non-canonical pathways (e.g., caspase-4/5/11). This review synthesizes current evidence and identifies molecular targets for optimizing EA-based neuroprotection post-SCI.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"28 ","pages":"Article 100414"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence-based healthcare cybersecurity system with blockchain: modified parallel convolutional neural network for attack detection 基于人工智能的医疗网络安全系统：改进的并行卷积神经网络攻击检测

Medicine in Novel Technology and Devices Pub Date : 2025-12-01 Epub Date: 2025-10-30 DOI: 10.1016/j.medntd.2025.100412

Swarooparani Kolsur , Sridevi Hosmani

{"title":"Artificial intelligence-based healthcare cybersecurity system with blockchain: modified parallel convolutional neural network for attack detection","authors":"Swarooparani Kolsur , Sridevi Hosmani","doi":"10.1016/j.medntd.2025.100412","DOIUrl":"10.1016/j.medntd.2025.100412","url":null,"abstract":"<div><div>While smart wearables and remote devices have improved the speed of diagnosis and treatment, they have also created significant cybersecurity risks, especially with regard to the confidentiality and integrity of medical data. Because the primary means of operation for these Internet of Things (IoT) devices is constant data transmission, they are vulnerable to cyberthreats including Distributed Denial-of-Service (DDoS) assaults and data injection. This study suggests an AI-based Healthcare Cybersecurity System (AI-HCSS) that integrates blockchain technology to mitigate these vulnerabilities and provide strong, real-time patient data and healthcare system protection. A new architecture is shown to identify and counteract DDoS attacks on the cloud infrastructure, and blockchain is used for safe and unchangeable data storage. The system extracts statistical, raw, and enhanced entropy-based features after performing improved min-max normalization for data pre-processing. Then, for precise DDoS attack detection, a modified Parallel Convolutional Neural Network (PCNN) is used. The model's output is interpreted using the SHapley Additive exPlanations (SHAP) approach, which identifies important characteristics that affect detection performance in order to improve transparency and aid clinical decision-making. According to experimental results, the modified PCNN outperforms traditional methods with a high detection accuracy of 91.1 %. In addition to bolstering the cybersecurity of healthcare IoT ecosystems, this integrated solution guarantees the real-time defense of clinical systems and patient data against changing cyberthreats.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"28 ","pages":"Article 100412"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DeepGene: Dual ensemble explainable pipeline for gene-based enhanced biomarker selection DeepGene：基于基因的增强生物标志物选择的双集成可解释管道

Medicine in Novel Technology and Devices Pub Date : 2025-12-01 Epub Date: 2025-10-22 DOI: 10.1016/j.medntd.2025.100411

Sayantan Dass , Sujoy Mistry , Debashis De , Pradyut Sarkar

{"title":"DeepGene: Dual ensemble explainable pipeline for gene-based enhanced biomarker selection","authors":"Sayantan Dass , Sujoy Mistry , Debashis De , Pradyut Sarkar","doi":"10.1016/j.medntd.2025.100411","DOIUrl":"10.1016/j.medntd.2025.100411","url":null,"abstract":"<div><div>Accurate and interpretable biomarker identification is crucial for effective cancer diagnosis and treatment. Conventional feature selection methods often struggle with instability and lack of transparency, especially when handling complex high-dimensional data. This paper presents the Dual Ensemble Explainable Pipeline for Gene-based Enhanced (DeepGene) Model to address these twin challenges. DeepGene integrates two ensemble strategies: one amalgamating filter-based techniques to discern the most discriminative and robust genes and another for identifying interpretable biomarkers through aggregating different explainable machine learning methodologies. A novel two-stage aggregation approach within the filter-based ensemble technique enhances gene selection, improving stability, exploration, and information integration. A comprehensive evaluation of public cancer microarray datasets demonstrates DeepGene's superior performance in stability and interpretability compared to state-of-the-art methods, resulting in a 3–10 % improvement in classification accuracy. These findings highlight DeepGene's potential to significantly advance cancer research and clinical practice, ultimately benefiting patients and healthcare providers.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"28 ","pages":"Article 100411"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145416575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photothermal nanomaterials-based scaffolds for tissue regeneration and cancer therapy 用于组织再生和癌症治疗的光热纳米材料支架

Medicine in Novel Technology and Devices Pub Date : 2025-12-01 Epub Date: 2025-08-30 DOI: 10.1016/j.medntd.2025.100395

Kuldeep Rajpoot

{"title":"Photothermal nanomaterials-based scaffolds for tissue regeneration and cancer therapy","authors":"Kuldeep Rajpoot","doi":"10.1016/j.medntd.2025.100395","DOIUrl":"10.1016/j.medntd.2025.100395","url":null,"abstract":"<div><div>Recently, photothermal therapy (PTT) has been considered a promising method for cancer treatment with fewer serious side effects compared to conventional radiation, chemotherapy and surgical resection. PTT is based on the photoconversion ability of photothermal agents (PTAs) as well as utilizes various nanomaterials (NMs) owing to their excellent photothermal properties. PTAs can penetrate tumor tissue, reduce local and systemic damage, and can be easily controlled. PTA-based composite scaffolds stimulate tissue reconstruction as well as regeneration following ablation of cancer cells, combining the advantages of photothermal NMs for maximum therapeutic efficacy with minimal side effects. Recently, hybrid PTAs as well as 3-dimensional scaffolds are being developed to maximize therapeutic efficacy along with minimal adverse effects, which make these composite scaffolds promising for biomedical applications. This review focuses on a detailed discussion on topics such as PTAs (i.e., organic polymer-based PTAs and inorganic PTAs) and PTT-mediated scaffolds for tissue regeneration such as PTA-based scaffolds, carbon NMs-based scaffolds, and gold NMs scaffolds, copper NMs-based scaffolds, iron NMs-based scaffolds, black phosphorus (BP)-based scaffolds, MXenes-based scaffolds and PTT-mediated scaffolds in cancer therapy.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"28 ","pages":"Article 100395"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the potential of In situ radiopaque bioactive glass in modern biomedical application-scope unforeseen 探索原位不透射线生物活性玻璃在现代生物医学中的应用潜力

Medicine in Novel Technology and Devices Pub Date : 2025-12-01 Epub Date: 2025-08-21 DOI: 10.1016/j.medntd.2025.100394

Rupam Saha , Jui Chakraborty

引用次数: 0

A review of blood pressure measurement methods based on Korotkoff sounds 基于科罗特科夫音的血压测量方法综述

Medicine in Novel Technology and Devices Pub Date : 2025-12-01 Epub Date: 2025-10-20 DOI: 10.1016/j.medntd.2025.100409

Ren Shuqi, Deng Xiaoyan, Fan Yubo, Sun Anqiang

{"title":"A review of blood pressure measurement methods based on Korotkoff sounds","authors":"Ren Shuqi, Deng Xiaoyan, Fan Yubo, Sun Anqiang","doi":"10.1016/j.medntd.2025.100409","DOIUrl":"10.1016/j.medntd.2025.100409","url":null,"abstract":"<div><div>Blood pressure measurement serves as a fundamental physiological parameter for clinical diagnosis and health monitoring, with its accuracy directly influencing the diagnostic and therapeutic outcomes of cardiovascular diseases. Since its discovery in 1905 by Russian surgeon Korotkoff, the blood pressure measurement method based on Korotkoff sounds has become the gold standard for non-invasive clinical blood pressure assessment. This review systematically explores the fundamental principles, technological evolution, clinical applications, and future developments of the Korotkoff sounds method. Through analysis of the five-phase characteristics of Korotkoff sounds, the intrinsic relationship between Korotkoff sound signals and hemodynamics is revealed. Furthermore, by integrating electronic auscultation technology, signal processing algorithms, and AI applications, targeted strategies to enhance measurement precision are discussed. Finally, the review expounds future trends toward intelligent and miniaturized devices, cuffless measurement techniques, and multimodal integration. This work aims to provide theoretical insights and technical guidance for clinical practice and medical device innovation.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"28 ","pages":"Article 100409"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145362643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring brain efficiency during exercise: A fNIRS graph theory analysis 在运动中探索大脑效率：fNIRS图论分析

Medicine in Novel Technology and Devices Pub Date : 2025-12-01 Epub Date: 2025-09-03 DOI: 10.1016/j.medntd.2025.100389

Guangyue Zhu , Guanghu Zhang , Yichen Jiang , Wenxi Li , Dongsheng Xu

{"title":"Exploring brain efficiency during exercise: A fNIRS graph theory analysis","authors":"Guangyue Zhu , Guanghu Zhang , Yichen Jiang , Wenxi Li , Dongsheng Xu","doi":"10.1016/j.medntd.2025.100389","DOIUrl":"10.1016/j.medntd.2025.100389","url":null,"abstract":"<div><div>This study seeks to elucidate the reduction in brain functional network connectivity during exercise compared to rest, utilizing graph theory techniques to analyze data from resting and movement phases across various exercise modalities. This study employed a graph theory approach to examine differences in brain network functions across various motor phases. The participants engaged in upper limb rehabilitation exercises, including passive, active, and resistance exercises, while functional near-infrared spectroscopy was used to monitor the motor-related cortex. Functional connectivity was reduced during exercise compared with rest, particularly during active and resistance exercises. Small-world network properties did not vary significantly between the two phases, although these properties were higher during movement under conditions of high sparsity. Both global and local efficiencies remained largely unchanged between phases. However, local efficiency increased during the active and resistance exercises in the movement phase. Node efficiency analysis indicated that the motor and supplementary motor areas played critical roles during exercise, with the movement phase exhibiting shorter path lengths. While the overall brain functional connectivity decreased during exercise, there was an improvement in the efficiency of specific brain nodes, suggesting a network mechanism that supports movement execution. During exercise, there was a decrease in whole-brain functional connectivity, yet an enhancement in brain efficiency was observed. This enhancement in functionality of specific nodes may signify the network mechanism responsible for movement execution.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"28 ","pages":"Article 100389"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational drug discovery of nitroimidazole compounds targeting Ddn protein of Mycobacterium tuberculosis: insights from QSAR modeling, ADMET, molecular docking, and molecular dynamics simulation studies 靶向结核分枝杆菌Ddn蛋白的硝基咪唑化合物的计算药物发现：来自QSAR建模、ADMET、分子对接和分子动力学模拟研究的见解

Medicine in Novel Technology and Devices Pub Date : 2025-12-01 Epub Date: 2025-09-18 DOI: 10.1016/j.medntd.2025.100406

Santhanavel Murugan , Anguraj Moulishankar , Sowmiya Palanivel , Kathiravan Muthu Kumaradoss , Sundarrajan Thirugnanasambandam

{"title":"Computational drug discovery of nitroimidazole compounds targeting Ddn protein of Mycobacterium tuberculosis: insights from QSAR modeling, ADMET, molecular docking, and molecular dynamics simulation studies","authors":"Santhanavel Murugan , Anguraj Moulishankar , Sowmiya Palanivel , Kathiravan Muthu Kumaradoss , Sundarrajan Thirugnanasambandam","doi":"10.1016/j.medntd.2025.100406","DOIUrl":"10.1016/j.medntd.2025.100406","url":null,"abstract":"<div><div>Still a major worldwide health issue, tuberculosis requires the development of new medicinal drugs. Computational techniques, including QSAR modeling, molecular docking, ADMET analysis, and molecular dynamics simulation, were used in this work, which examines the antitubercular potential of a nitroimidazole derivative targeting the Ddn protein of <em>Mycobacterium tuberculosis</em>. A multiple linear regression-based QSAR model (R<sup>2</sup> = 0.8313, Q<sup>2</sup><sub>LOO</sub> = 0.7426) created using QSARINS software shows strong prediction accuracy for anti-TB activity. Using molecular docking experiments (AutoDockTool 1.5.7), DE-5 compound was found to be the most promising molecule with a binding affinity of −7.81 kcal/mol and important hydrogen bonding interactions with active site residues PRO A:63, LYS A:79, and MET A:87. High bioavailability, good pharmacokinetics, and low toxicity risk were found by ADMET profiling (SwissADME). A 100 ns molecular dynamics simulation confirmed the stability of the DE-5-Ddn complex, as indicated by minimal Root Mean Square deviation, stable hydrogen bonds, low Root Mean Square Fluctuation, and compact structure reflected in Solvent Accessible Surface Area and radius of gyration values. Furthermore, MM/GBSA computations (−34.33 kcal/mol) confirmed a strong binding affinity and hence supporting DE-5's activity potential. These findings suggest that DE-5 is a suitable potential compound to advance the creation of new tuberculosis therapies targeting the Ddn protein. This work opens the path for logical drug design strategies in the TB battle.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"28 ","pages":"Article 100406"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The biomechanical effects of patient bone osteoporosis on tibial prosthesis fixation in total knee arthroplasty 全膝关节置换术中患者骨质疏松对胫骨假体固定的生物力学影响

Medicine in Novel Technology and Devices Pub Date : 2025-12-01 Epub Date: 2025-10-27 DOI: 10.1016/j.medntd.2025.100413

Shichuang Gong , Jing Zhang , Jianian Han , Tianqi Dong , Weijie Zhang , Zhenxian Chen , Shuxin Yao , Jianbing Ma

{"title":"The biomechanical effects of patient bone osteoporosis on tibial prosthesis fixation in total knee arthroplasty","authors":"Shichuang Gong , Jing Zhang , Jianian Han , Tianqi Dong , Weijie Zhang , Zhenxian Chen , Shuxin Yao , Jianbing Ma","doi":"10.1016/j.medntd.2025.100413","DOIUrl":"10.1016/j.medntd.2025.100413","url":null,"abstract":"<div><div>Osteoporosis is a prevalent comorbidity among patients with knee osteoarthritis. This study employed finite element analysis to investigate the biomechanical effects of tibial osteoporosis on prosthetic fixation in total knee arthroplasty (TKA) by simulating varying degrees of osteoporosis through adjustments in material properties. The results indicated that as the tibial elastic modulus decreased, the maximum von Mises stress of the tibia was reduced, whereas the prosthetic stress increased. The contact pressure on the tibial tray stem diminished, and the tibial tray baseplate displacement, cement shear stress, and micromotion at the fixation interface were elevated. Notably, when the modulus was reduced to 60 % of its initial value, the tilting of the tibial tray baseplate increased by 33.72 %. Under these conditions, the cement shear stress reached −4.22 MPa, approaching the fatigue limit of 5 MPa, and the peak interface micromotion attained 66.2 μm, exceeding the optimal threshold for bone ingrowth. These findings underscore the necessity for surgeons to assess bone quality before TKA. With progressive osteoporosis, the risk of stress shielding increased significantly, while the risk of bone fracture became inevitable. These findings indicated that patients with severe osteoporosis may face challenges in achieving fixation stability. Consequently, we advocate for the consideration of full cement fixation and/or the utilization of an extended stem to restore initial stability for patients with severe osteoporosis.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"28 ","pages":"Article 100413"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145465808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0