Medicine in Novel Technology and Devices最新文献

{"title":"Recent advances in CRISPR/Cas systems-associated surface enhanced Raman spectroscopy biosensor towards nucleic acid detection","authors":"Dongjie Zhang ,&nbsp;Siyuan He ,&nbsp;Zixu Wang ,&nbsp;Peirao Yan ,&nbsp;Huandi Li ,&nbsp;Xinyi Xu ,&nbsp;Qi Zeng ,&nbsp;Nan Wang ,&nbsp;Xueli Chen","doi":"10.1016/j.medntd.2024.100336","DOIUrl":"10.1016/j.medntd.2024.100336","url":null,"abstract":"<div><div>Nucleic acids play a decisive role in vital life processes, such as growth, heredity, and evolution, and exploring different types of nucleic acid detection techniques has always been a research hotspot worldwide. Compared to traditional nucleic acid analysis methods, surface-enhanced Raman spectroscopy (SERS) detection has advantages, such as high sensitivity, good specificity, narrow spectral bands, minimal sample requirement, simple operation, and resistance to interference from autofluorescence and water in biological samples. The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system has gained widespread attention in the fields of gene editing and biosensors. Combining the sequence-specific recognition capability of the CRISPR/Cas system with the high sensitivity fingerprinting properties of SERS technology offers a simple, rapid, and sensitive method towards nucleic acid detection. Here, common SERS Nanotags methods for nucleic acid detection are introduced, including “sandwich assay”, “signal switch assay” and HCR signal amplification. Then, the building mechanism of CRISPR-associated SERS detection is summarized. CRISPR/Cas12a activated by crRNA can recognize and lock the complementary target double-stranded DNA (dsDNA), followed by cis-cleavage of the dsDNA and trans-cleavage of the adjacent linker ssDNA. The loss of SERS signal based on aggregation is finally used for highly sensitive detection of the target DNA. Lastly, some typical applications through the integration of CRISPR/Cas and SERS technology are introduced, such as HIV-1 dsDNA, HBV DNA and AFB1 etc.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100336"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-printed shoulder and elbow exercise device for stroke patients- A pilot study","authors":"Porkodi Jayavel ,&nbsp;Varshini Karthik ,&nbsp;Jaison Jacob Mathunny ,&nbsp;Suresh Jothi ,&nbsp;Ashokkumar Devaraj","doi":"10.1016/j.medntd.2024.100333","DOIUrl":"10.1016/j.medntd.2024.100333","url":null,"abstract":"<div><div>Upper limb movements are essential in everyday life; hand paralysis caused by post-stroke affects the regular lives of patients. To regain hand mobility and motor function, we must perform repetitive exercises. Nowadays, rehabilitation devices are essential to help post-stroke victims exercise and recover from paralysis more quickly. The proposed research developed a 3D-printed portable rehabilitative device for elbow and shoulder movements. This device assists patients with hand impairments in performing repetitive elbow flexion and internal/external rotation of the shoulder. Twenty post-stroke patients (each group of 10) were randomly assigned to the traditional training group or rehabilitation device training group. This study compared the outcomes of the two groups before and after eight weeks of training. Following the therapy, the patient's performance was evaluated using standard clinical tests such as the Fugl-Meyer Assessment (FMA) and Active Range of Motion (AROM) of the elbow and shoulder. The results of the RDT (Rehabilitation Device Training) group were greater than those of the TT (Traditional Training) group, and the p values (p ​&lt; ​0.05) show a significant improvement. The proposed device is a simple, low-cost, portable structure that improves muscular strength and mobility in the shoulder and elbow.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100333"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying gender differences in orbital morphology with large MRI datasets","authors":"Yingxiang Han ,&nbsp;Qi Li ,&nbsp;Tingting Liu ,&nbsp;Zengsheng Chen ,&nbsp;Xi Chen ,&nbsp;Xiaofei Wang","doi":"10.1016/j.medntd.2024.100332","DOIUrl":"10.1016/j.medntd.2024.100332","url":null,"abstract":"<div><h3>Purpose</h3><p>To investigate gender differences in orbital morphology using large MRI datasets.</p></div><div><h3>Methods</h3><p>Using a deep learning-based approach, the orbit and eyeball were automatically segmented from high resolution 3D MRI images of the IXI and OASIS3 datasets. Orbital and eyeball morphological parameters, including orbital volume, eyeball volume, effective orbital volume (EOV, defined as the orbital cavity volume excluding the eyeball), and coronal orbital dimensions and shape, were quantitatively assessed. The volume index was defined as the ratio of orbital volume to eyeball volume.</p></div><div><h3>Results</h3><p>This study included 1926 subjects with a mean age of 63.9 ​± ​15.3 years. The mean volumes of the eyeball and orbit were 7.1 ​± ​1.0 ​ml and 25.9 ​± ​3.5 ​ml, respectively. Significant gender differences (all P ​&lt; ​0.001) were observed in the following parameters (males versus females): orbital volume (28.3 ​± ​3.0 ​ml versus 24.0 ​± ​2.7 ​ml), EOV (25.1 ​± ​3.0 ​ml versus 21.1 ​± ​2.6 ​ml), eyeball volume (7.3 ​± ​1.0 ​ml versus 6.9 ​± ​1.0 ​ml), volume index (3.9 ​± ​0.6 versus 3.5 ​± ​0.5), orbital depth (40.0 ​± ​3.1 ​mm versus 37.4 ​± ​2.9 ​mm), coronal orbital height (40.8 ​± ​3.0 ​mm versus 38.4 ​± ​2.4 ​mm), coronal orbital width (38.0 ​± ​1.9 ​mm versus 36.6 ​± ​1.7 ​mm) and coronal orbital area (1292.5 ​± ​97.1 ​mm² versus 1177.9 ​± ​89.7 ​mm²).</p></div><div><h3>Conclusions</h3><p>This study employed deep learning to analyze a large dataset of 3D head MRI scans, achieving accurate and objective measurements of orbital morphology. We identified significant gender differences in orbital parameters, with males generally having larger structures. Additionally, we established a normative database for orbital dimensions, providing a valuable resource for future research on orbital disorders and potentially improving clinical diagnosis and treatment.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100332"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000481/pdfft?md5=d7d4ebfcca38920363bf2ba466b1a9af&pid=1-s2.0-S2590093524000481-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover","authors":"","doi":"10.1016/S2590-0935(24)00060-2","DOIUrl":"10.1016/S2590-0935(24)00060-2","url":null,"abstract":"","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100344"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143138444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of type I and II collagen in osteochondral tissue engineering: Respective features and future perspectives","authors":"Ruoyu Huang,&nbsp;Xiaolian Niu,&nbsp;Xueying Li,&nbsp;Xiaoming Li","doi":"10.1016/j.medntd.2024.100328","DOIUrl":"10.1016/j.medntd.2024.100328","url":null,"abstract":"<div><p>At present, osteoarthritis stands as one of the most prevalent degenerative musculoskeletal diseases globally. The inherent lack of self-healing capacity in articular cartilage presents a considerable obstacle in treating osteoarthritis. Tissue engineering emerged as a promising strategy for the regeneration of osteochondral defects. Collagen, a primary component of bone and cartilage, stands out as a widely utilized natural material in osteochondral tissue engineering. Among various collagen types, Type I and type II collagen are notably prominent in this field. This review initially summarizes the advantageous and disadvantageous properties of type I/II collagen in osteochondral tissue engineering, proceeds to introduce their applications in this context, and concludes with a prospective outlook on the future development of type I/II collagen's applications.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100328"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000444/pdfft?md5=f1a3f6bb134e000bc445dff049786a89&pid=1-s2.0-S2590093524000444-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142149028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modelling nematic liquid crystal in fractal dimensions","authors":"Rami Ahmad El-Nabulsi","doi":"10.1016/j.medntd.2024.100334","DOIUrl":"10.1016/j.medntd.2024.100334","url":null,"abstract":"<div><div>In this paper we present a fractal Berreman's model which account for azimuthal surface anchoring of nematic liquid crystals which play a leading role nowadays in biomedical field and pharmaceutical controlled release dosage forms. The model is based on the concept of “product-like fractal measure” in anisotropic media which permits to describe liquid crystals formation in terms of fractal dimensions. It was observed that fractal dimensions affect both the polar azimuthal angle and the Franck excess elastic energy density of the distortion. For fractal dimensions close to unity, our analysis reveals the emergence of fluctuations and large deformations in the dynamical variables of the theory which suggest the presence of non-linear elastic instabilities or emergence of defect structures in liquid crystals. These fluctuations fade away for fractal dimensions much less than unity. We have evaluated the elastic energy per unit of area which is found to depend on the square of the fractal dimension. This leads to a decrease of the saturation voltage which is necessary to reduce the elastic energy of liquid crystals films in order to minimize the elastic energy. This reduction may describe nematic liquid crystals free from deformations, singularities or weak anchoring surfaces.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100334"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient quantum of mechanical simulation of diffusion-weighted MRI","authors":"Ahmed J. Allami ,&nbsp;Hany Akeel Al-Hussaniy ,&nbsp;Amjad Ibraim Oraibi ,&nbsp;Zuhair Abdulkareem Dawah","doi":"10.1016/j.medntd.2024.100339","DOIUrl":"10.1016/j.medntd.2024.100339","url":null,"abstract":"<div><div>Modern magnetic resonance imaging (MRI) experiments require simultaneous spin and spatial dynamics treatment. This paper aims to demonstrate the possibility of simulating a large spin system for diffusion-weighted MRI experiments. The numerical simulation of diffusion MRI depends on Bloch-Torrey equations. The latter describe the behavior of spin systems under the influence of magnetic fields and diffusion processes. They are particularly relevant in magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) studies. The equations deal with uncoupled (−1/2) spins associated with three-dimensional spatial dynamics represented by diffusion and flow. The proposed method recommends using an unopened Kronecker product for evolution generators to minimize the simulation time and reduce the occupied computer memory. Two and three-dimensional diffusion-weighted magnetic resonance imaging associated with four pairs of coupled spin systems were utilized to achieve the study's goals. Utilizing four pairs of coupled spin systems in MRI simulation enhances accuracy and realism in modeling interactions between spins, leading to improved tissue characterization and diagnostic capabilities. The obtained results were impossible using previous simulation packages. The results of the study demonstrate that the Spinach library can simulate complex spin systems with significant spatial dynamics.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100339"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining mental workload based on multiple physiological signals: Review of the multi-attribute task battery (MATB) technique","authors":"Jiapu Chai,&nbsp;Yan Li","doi":"10.1016/j.medntd.2024.100340","DOIUrl":"10.1016/j.medntd.2024.100340","url":null,"abstract":"<div><div>MATB (Multi-Attribute Task Battery), developed by NASA, simulates real-world task demands and work environments. It assesses human cognitive and executive abilities in high-load, complex task settings, as well as their adaptive capacity for task switching and attention allocation. This article reviews MATB's primary applications and usage, exploring mental workload-related research with MATB, analyzing experimental procedure design, objective physiological signals, and model construction. This analysis facilitates a comprehensive understanding of utilizing MATB for mental workload experiments and improving experimental design. Additionally, it proposes a more comprehensive and scientific experimental procedure for cognitive load research using MATB. Through this review, researchers gain insights into the versatility and potential of MATB as a tool for assessing mental workload and optimizing experimental design in various fields.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100340"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142655172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatocellular carcinoma imaging: Exploring traditional techniques and emerging innovations for early intervention","authors":"Hariharan Thirumalai Vengateswaran ,&nbsp;Mohammad Habeeb ,&nbsp;Huay Woon You ,&nbsp;Kiran Balasaheb Aher ,&nbsp;Girija Balasaheb Bhavar ,&nbsp;Govind Sarangdhar Asane","doi":"10.1016/j.medntd.2024.100327","DOIUrl":"10.1016/j.medntd.2024.100327","url":null,"abstract":"<div><p>Hepatocellular carcinoma (HCC) continues to be a diagnostic and therapeutic challenge for healthcare systems around the world in addition to being a significant contributor to oncologic mortality. To improve the standard of life and the survival of patients, early diagnosis of the condition and subsequent appropriate treatment are essential. Hepatocellular carcinoma (HCC) observation, early detection, diagnosis, and follow-up all depend heavily on imaging modalities. They provide valuable information about the characteristics of HCC nodules, aiding in non-invasive diagnosis and staging. Imaging has evolved beyond simply confirming a suspected diagnosis in the management of hepatocellular carcinoma (HCC). Several traditional imaging modalities, including PET/CT, MRI, MR elastography, ultrasound (US), and endoscopy, along with next-generation imaging modalities such as photoacoustic imaging, and Cerenkov luminescence with the utilization of contrasting agents further enhance their diagnostic capabilities in HCC. The selection of the most appropriate imaging modality and contrasting agent depends on various factors, including the clinical scenario, patient characteristics, and availability of resources. In addition to these advancements, artificial intelligence (AI) has developed as a valuable tool in radiology for the management of HCC. In this review, we highlighted the most important imaging techniques for managing patients with a high risk of HCC.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100327"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000432/pdfft?md5=96a2ed1026601e6e818f337c6c0f729b&pid=1-s2.0-S2590093524000432-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of microneedle arrays in cosmetics: Promises, advances, and challenges","authors":"Amarjitsing Rajput ,&nbsp;Anuradha Patil ,&nbsp;Priyanka Kandhare ,&nbsp;Atmaram Pawar","doi":"10.1016/j.medntd.2024.100325","DOIUrl":"10.1016/j.medntd.2024.100325","url":null,"abstract":"<div><p>Microneedle technology involves skin puncturing and has emerged as an innovative approach for drug delivery and cosmetic applications. MNs offer advantages over traditional injections, such as reduced pain, infection risks, and improved control of drug delivery. Cosmetic products aim to alter or enhance the appearance of the human body, while transdermal drug delivery involves administering drugs via the skin for local or systemic treatment. The use of MNs in combination with cosmetics has shown promise in improving nutrient delivery, skin healing, and penetration of cosmeceuticals. The development of microfabrication technologies has allowed the production of MNs in various sizes, shapes, and materials mainly used for loading cosmetic compounds. Clinical trial studies have explored MNs' clinical potential in drug delivery, diagnosis and administration of cosmeceuticals. The review highlights the superior efficacy of dissolving MNs in enhancing transdermal drug delivery compared to traditional methods, which are currently used by several researchers and evidenced by multiple clinical studies. The current review article compilation encompasses the microneedle in cosmetic delivery and its applications in managing various skin diseases. It differs from earlier available reviews on MNs in several aspects, novelty lies as it describes microneedle applications in cosmetics. It also focuses on recent technologies for transdermal delivery like iontophoresis, sonophoresis, magnetophoresis, electroporation, laser ablation, and jet injectors. It mainly covers the role of MNs in managing various diseases by covering case studies. It also covers challenges, commercial successes, safety measures, regulatory facts, and future perspectives of microneedles in cosmetic delivery. This article highlights the potential of MNs to revolutionize transdermal drug delivery, which will benefit various industries and patients worldwide. Furthermore, this article emphasizes the potential impact of ongoing research and commercialization of MNs.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100325"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000419/pdfft?md5=d8f7255a0df65c916af814ce3437bb07&pid=1-s2.0-S2590093524000419-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}