Medicine in Novel Technology and Devices最新文献

{"title":"Sensitivity, repeatability and reproducibility study with a leg prototype of a recently developed knee arthrometer: The DYNEELAX®","authors":"Théo Cojean, C. Batailler, H. Robert, L. Chèze","doi":"10.1016/j.medntd.2023.100254","DOIUrl":"https://doi.org/10.1016/j.medntd.2023.100254","url":null,"abstract":"","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"113 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54879310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CP-AnemiC: A ​conjunctival pallor dataset and benchmark for anemia detection in children","authors":"Peter Appiahene ,&nbsp;Kunal Chaturvedi ,&nbsp;Justice Williams Asare ,&nbsp;Emmanuel Timmy Donkoh ,&nbsp;Mukesh Prasad","doi":"10.1016/j.medntd.2023.100244","DOIUrl":"10.1016/j.medntd.2023.100244","url":null,"abstract":"<div><p>Anemia is a universal public health issue, which occurs as the result of a reduction in red blood cells. This disease is common among children in Africa and other developing countries. If not treated early, children may suffer long-term consequences such as impairment in social, emotional, and cognitive functioning. Early detection of anemia in children is highly desirable for effective treatment measures. While there has been research into the development of computer-aided diagnosis (CAD) systems for anemia diagnosis, a significant proportion of these studies encountered limitations when working with limited datasets.</p><p>To overcome the existing issues, this paper proposes a large dataset, named CP-AnemiC, comprising 710 individuals (range of age, 6–59 months), gathered from several hospitals in Ghana. The conjunctiva image-based dataset is supported with Hb levels (g/dL) annotations for accurate diagnosis of anemia. A joint deep neural network is developed that simultaneously classifies anemia and estimates hemoglobin levels (g/dL) based on the conjunctival pallor images. This paper conducts a comprehensive experiment on the CP-AnemiC dataset. The experimental results demonstrate the efficacy of the joint deep neural network in both the tasks of anemia classification and Hb levels (g/dL) estimation.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"18 ","pages":"Article 100244"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49369041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Composite double-layer microneedle loaded with traditional Chinese medicine for the treatment of androgenic alopecia","authors":"Ruoxi Wang,&nbsp;Jiangge Wang,&nbsp;Haiqiang Gao,&nbsp;Xiangyi Liao,&nbsp;Chunyang Ma,&nbsp;Xufeng Niu","doi":"10.1016/j.medntd.2023.100216","DOIUrl":"10.1016/j.medntd.2023.100216","url":null,"abstract":"<div><p>Androgenetic alopecia (AGA) is an androgen-mediated alopecia affected by both genes and hormones. Medication is a relatively common treatment. As a new drug delivery method, microneedles (MNs) can effectively break through the stratum corneum barrier, deliver drugs more efficiently, and achieve better therapeutic effects. In this study, we develop a composite double-layer MN through multi-step casting fabrication using a polydimethylsiloxane mold. The needle tip was fabricated by mixed solution of chitosan and polyvinylpyrrolidone which was loaded with <em>Polygonum multiflorum</em> extract, and the base layer was prepared by mixed solution of polyvinyl alcohol and polyvinylpyrrolidone. In vitro mechanical tests showed that the maximum load of a single tip of the drug-loaded MN was about 3.5 ​N, which met the mechanical requirements of skin puncture (&gt;1 ​N). The drug release experiment showed that the MN could achieve gradual drug release. In the animal experiment, pigmentation and hair regrowth occurred earlier in the <em>Polygonum multiflorum</em>-MN (<em>Pm</em>-MN) group than in the other groups, and hair growth finally appeared in almost the entire area. Compared with the AGA model mice, mice in the <em>Pm</em>-MN group achieved an increase in the number and diameter of hair follicles. In conclusion, the <em>Pm</em>-MN is scientific and feasible for treating AGA.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"18 ","pages":"Article 100216"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41578662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamics in renal arteries with partial coverage after endovascular aneurysm repair affected by renal orientations","authors":"Jun Wen ,&nbsp;Xinhui Liu ,&nbsp;Jianguo Lei ,&nbsp;Jiarong Wang ,&nbsp;Xiyang Chen ,&nbsp;Tinghui Zheng ,&nbsp;Ding Yuan","doi":"10.1016/j.medntd.2023.100224","DOIUrl":"10.1016/j.medntd.2023.100224","url":null,"abstract":"<div><p>Endovascular aortic repair (EVAR) has been increasingly used to treat abdominal aortic aneurysm (AAA) due to its lower mortality and shorter recovery time. However, the complications caused by renal artery coverage remained a major concern. In this study, three types of renal orientation and five types of partial renal coverage degree were adopted to numerically investigate the flow pattern, wall shear stress distribution, and blood perfusion during a cardiac cycle. The results show that as for the mild partial coverage (=&lt;30%), the renal artery with a downward orientation suffered fewer unfavorable wall shear stress (WSS) distribution and more blood perfusion. It should be noted that the renal artery with horizontal orientation suffered more unfavorable WSS distribution. In terms of severe coverage (≥50%), all of the renal arteries displayed highly disturbed wall shear distribution, resulting in a significant reduction in blood perfusion It was interesting to note that the artery with an upward orientation had a smaller rate of reduction in blood perfusion. It can be concluded that as for the mild renal coverage after EVAR, renal arteries with downward orientation may have the advantage of reducing the possibility of renal occlusion, while renal arteries with horizontal orientation may increase the unfavorable wall shear distribution. On the other hand, as for serious coverage (≥50%), high risk of renal ischemia remains the main concern for all types of renal arteries due to highly disturbed wall shear distribution would significantly increase regardless of renal orientation.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"18 ","pages":"Article 100224"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47611769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swirling flow and capillary diameter effect on the performance of an active dry powder inhalers","authors":"Mohammad Hasan Taheri ,&nbsp;Nematollah Askari ,&nbsp;Yaning Feng ,&nbsp;Malikeh Nabaei ,&nbsp;Mohammad S. Islam ,&nbsp;Ali Farnoud ,&nbsp;Xinguang Cui","doi":"10.1016/j.medntd.2023.100240","DOIUrl":"10.1016/j.medntd.2023.100240","url":null,"abstract":"<div><p>For patients with lung disease, dry powder inhalers (DPI) are profoundly beneficial. The current study introduces and develops a series of dry powder inhalers (DPIs). A capsule-based (size 0) active DPI was considered. The study aims to investigate whether swirling flow and outlet capillary diameter (d_{c_out}) affect the percentage of emitted doses (ED) released from the capsule. Spiral vanes were added to the capillary inlet to produce a swirling flow. Computational fluid dynamics (CFD) was applied to simulate the problem. The results were compared with previous in vitro and numerical studies to validate the results. Based on the derived results, the small swirl parameter (SP) enhances the secondary flow and recirculation zone. It increases the central jet flow, which increases the ED value by about 5–20% compared to no-swirl flow. However, as the airflow rate increases, the recirculation zone enlarges, vorticities become dominant, and asymmetrical flow patterns emerge. Consequently, ED % drops significantly (more than 50%). As d_{c_out} decreases, the vorticities around the outlet capillary become more potent, which is undesirable. Indeed, the emptying of the capsule does not happen ideally. The research provides a perspective on the device's design and DPI performance.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"18 ","pages":"Article 100240"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43620971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of β-cyclodextrin on the hemocompatibility of heparin-modified PMP hollow fibrous membrane for Extracorporeal Membrane Oxygenation (ECMO)","authors":"Xingrui Zhong ,&nbsp;Ting He ,&nbsp;Zhaohui Wang ,&nbsp;Yawei Wang ,&nbsp;Linhao Li ,&nbsp;Zhaoliang Cui","doi":"10.1016/j.medntd.2023.100229","DOIUrl":"10.1016/j.medntd.2023.100229","url":null,"abstract":"<div><p>In this paper, modified membranes containing β-cyclodextrin (β-CD) and heparin coatings were prepared on the surface of poly-4-methyl-1-pentene (PMP) hollow fibrous membrane using the high strength adhesion of polydopamine (PDA). In this paper, β-CD was added to increase the hemocompatibility of the PMP hollow fibrous membranes and the stability of the heparin coating. The uniformity of the heparin coating with β-CD addition was better than that of the groups without β-CD. After seven days of saline rinsing, the surface of the modified membranes with β-CD addition still had a large amount of heparin present, which was more stable compared to the control group. After surface modification, the modified membrane changed from hydrophobic to hydrophilic. Importantly, the protein adsorption, platelet adhesion, and hemolysis rates of the modified membranes were significantly reduced compared with the pristine membranes. The APTT values were also significantly increased. The results showed that the modified membranes with the addition of β-CD had better hydrophilicity, can maintain the stability of heparin coating for a long time, and finally showed good hemocompatibility.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"18 ","pages":"Article 100229"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42566118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of morphology and hemodynamics on thrombosis in kawasaki disease patients","authors":"Haoyao Cao ,&nbsp;Zhuxiang Xiong ,&nbsp;Zhan Liu ,&nbsp;Yan Li ,&nbsp;Huaxia Pu ,&nbsp;Jing Liu ,&nbsp;Liqing Peng ,&nbsp;Tinghui Zheng","doi":"10.1016/j.medntd.2023.100225","DOIUrl":"10.1016/j.medntd.2023.100225","url":null,"abstract":"<div><p>Kawasaki Disease (KD) patients with co-occurrent coronary artery aneurysms (CAAs) are prone to thrombosis. This study explores the thrombotic influence of morphology and hemodynamics in KD patients with CAAs. Patient-specific computed tomography angiogram images of 9 patients were used to rebuild coronary models (including 23 aneurysms; 10 in thrombosed group, and 13 in non-thrombosed group) and perform computational simulations to obtain the hemodynamic parameters. The thrombosed and non-thrombosed groups were compared in terms of six parameters, namely, the maximum diameter (D_max), aspect ratio (R_l/d), shape, time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI), and relative residence time (RRT). The results showed that: (1) In thrombosed aneurysms, there were several vortex structures (eddy zone), of which the position changed continuously in a cardiac cycle. In non-thrombosed aneurysms, the streamlines showed a large streaming zone. (2) Abnormal hemodynamic areas of aneurysms with thrombosis tended to appear in the same region (especially the proximal and near myocardial side of aneurysms). (3) In the non-thrombosed group, there was a correlation between the morphological and hemodynamic parameters. In thrombosed aneurysms, the flow pulsatility has a significant impact on the flow pattern. The thrombosed coronary aneurysms exhibited more risk factors and the co-location of hemodynamic abnormalities was consistent with the position of thrombosis. A score of risk factors could provide the thrombotic information of coronary aneurysms, which might be helpful for long-term clinical management of KD patients.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"18 ","pages":"Article 100225"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47548274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The model of electrified cell clusters in biological tissues basing on the resting potential difference","authors":"Yufang He ,&nbsp;Peiguo Xu ,&nbsp;Huijie Wu ,&nbsp;Yong Chu ,&nbsp;Guanglei Zhang","doi":"10.1016/j.medntd.2023.100218","DOIUrl":"10.1016/j.medntd.2023.100218","url":null,"abstract":"<div><p>The resting potential is the potential difference that exists between the inner and outer sides of the cell membrane when the cell is not stimulated. The resting membrane potential is a key regulator of phenomena such as cell proliferation, morphogenesis, migration and differentiation. In this paper, we proposed a model of electrified cell clusters that considers the resting potential of cell clusters in the resting state. By measuring the potential difference between the inner and outer sides of biological tissues, it is verified that the cell cluster has a negative potential difference when taking the outer potential as the reference. In the absence of external conductors, the tissue is electrically neutral; while in the presence of external conductors, the positive net charges escape freely under repulsive forces and the biological tissues form a negative electrical equilibrium system. The model proposed in this study explored the potential situation above the cellular level in the resting state, providing a new perspective for the research on resting potential.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"18 ","pages":"Article 100218"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48011733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of 3D anchorage attachment on the alleviating tipping/extrusion of premolars for en-mass distalization of maxillary molars with clear aligners: A finite element study","authors":"Lurong Jia ,&nbsp;Chunjuan Wang ,&nbsp;Yao He ,&nbsp;Chao Wang ,&nbsp;Antonio Apicella ,&nbsp;Jinlin Song ,&nbsp;Yubo Fan","doi":"10.1016/j.medntd.2023.100231","DOIUrl":"10.1016/j.medntd.2023.100231","url":null,"abstract":"<div><p>This study aimed to explore the optimal invisible orthodontic force system during the en-mass distalization of two maxillary molars to minimize the side effect of anchorage loss by changing the direction of the application of the orthodontic force system. A high bio-fidelity 3D finite element model including maxilla, periodontal ligament, dentition, clear aligner, 3D anchorage attachment and mini-implant was established. Different lengths of lateral hooks of 3D-printed anchorage attachments and mini-implant positions into the palatal alveolus were considered. A 200 ​g distal force was applied to the lateral hooks of different horizontal lengths (3.26 ​mm, 6.52 ​mm and 9.78 ​mm) with the mini-implant as the application point. Using ABAQUS software, orthodontic tooth movements under 12 different clinical treatment designs were analyzed and calculated. The 3D anchorage attachment enhanced the anchorage of anterior teeth and alleviated the tipping/extrusion of premolars. In contrast to without clear aligners, length of the lateral hook had a negligible effect on both mesial tipping and buccal tipping with clear aligners, which could then be ignored. The change in mesial tipping was less and nearly remained constant despite of the different heights of the mini-implant. The 3D anchorage attachment assisted clear aligner can avoid the side effects of anterior tooth proclination caused by insufficient anchorage. The length of the lateral hook, and height of the mini-implant in this invisible orthodontic force system hardly affects the tooth movement of anchorage units. Clear aligners can effectively control the rotation and tipping of anchorage units caused by 3D anchorage attachment.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"18 ","pages":"Article 100231"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49407229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning based detection of monkeypox virus using skin lesion images","authors":"Tushar Nayak ,&nbsp;Krishnaraj Chadaga ,&nbsp;Niranjana Sampathila ,&nbsp;Hilda Mayrose ,&nbsp;Nitila Gokulkrishnan ,&nbsp;Muralidhar Bairy G ,&nbsp;Srikanth Prabhu ,&nbsp;Swathi K. S ,&nbsp;Shashikiran Umakanth","doi":"10.1016/j.medntd.2023.100243","DOIUrl":"10.1016/j.medntd.2023.100243","url":null,"abstract":"<div><p>As we set into the second half of 2022, the world is still recovering from the two-year COVID-19 pandemic. However, over the past three months, the outbreak of the Monkeypox Virus (MPV) has led to fifty-two thousand confirmed cases and over one hundred deaths. This caused the World Health Organisation to declare the outbreak a Public Health Emergency of International Concern (PHEIC). If this outbreak worsens, we could be looking at the Monkeypox virus causing the next global pandemic. As Monkeypox affects the human skin, the symptoms can be captured with regular imaging. Large samples of these images can be used as a training dataset for machine learning-based detection tools. Using a regular camera to capture the skin image of the infected person and running it against computer vision models is beneficial. In this research, we use deep learning to diagnose monkeypox from skin lesion images. Using a publicly available dataset, we tested the dataset on five pre-trained deep neural networks: GoogLeNet, Places365-GoogLeNet, SqueezeNet, AlexNet and ResNet-18. Hyperparameter was done to choose the best parameters. Performance metrics such as accuracy, precision, recall, f1-score and AUC were considered. Among the above models, ResNet18 was able to obtain the highest accuracy of 99.49%. The modified models obtained validation accuracies above 95%. The results prove that deep learning models such as the proposed model based on ResNet-18 can be deployed and can be crucial in battling the monkeypox virus. Since the used networks are optimized for efficiency, they can be used on performance limited devices such as smartphones with cameras. The addition of explainable artificial intelligence techniques LIME and GradCAM enables visual interpretation of the prediction made, helping health professionals using the model.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"18 ","pages":"Article 100243"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9699411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}