Medicine in Novel Technology and Devices最新文献

{"title":"Cover","authors":"","doi":"10.1016/S2590-0935(25)00024-4","DOIUrl":"10.1016/S2590-0935(25)00024-4","url":null,"abstract":"","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"26 ","pages":"Article 100373"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mass transport and fluid flow-induced wall shear stress in auxetic bone scaffolds during deformation process: a numerical study","authors":"Xuezheng Geng ,&nbsp;Nan Li ,&nbsp;Huiwen Huang ,&nbsp;Ruiqi Zhang ,&nbsp;Yan Yao ,&nbsp;Lizhen Wang ,&nbsp;Yubo Fan","doi":"10.1016/j.medntd.2025.100368","DOIUrl":"10.1016/j.medntd.2025.100368","url":null,"abstract":"<div><div>Auxetic structures exhibit an extraordinary response to mechanical forces by expanding or contracting in the transverse direction during stretching or compression, making them highly suitable for porous biomedical implants. However, their biological functions, including nutrient transport, metabolic waste removal, and cell proliferation and differentiation, remain unexplored. This study employs computational fluid dynamics (CFD) to analyze how the auxetic deformation of a scaffold influences its biological performance. An auxetic scaffold (A-scaffold) was designed alongside a non-auxetic scaffold (N-scaffold) with identical porosity (80 ​%) for comparison. Deformations at compressive strains of 0 ​%, 5 ​%, and 10 ​% were analyzed and utilized in CFD simulations to evaluate the fluid dynamics within the scaffolds. The interaction of water flow with the scaffolds was simulated, leading to predictions of mass transport and fluid flow-induced wall shear stress (WSS). Results indicated that both the fluid flow direction and scaffold architecture significantly influenced mass transport characteristics. The deformation response also impacted scaffold biological performance; specifically, the A-scaffold's concave struts hindered fluid flow in the X direction, reducing permeability but potentially promoting uniform internal fluid distribution. Although the auxetic deformation of the A-scaffold decreased its permeability, it resulted in a more irregular WSS distribution, suggesting enhanced dynamic cellular stimulation under mechanical loading. The WSS_AVG of the A-scaffold and its variation during deformation were larger in the X direction than that of the Z direction. As a result, the A-scaffold exhibited better ability to transmit mechanical stimulation in the X direction. These preliminary studies numerically characterized the mass transport properties of scaffolds under auxetic deformation for the first time, provided guidance for the design and application of an auxetic scaffold.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"26 ","pages":"Article 100368"},"PeriodicalIF":0.0,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomaterials and tissue engineering strategies for management of neurodegeneration: A critical perspective","authors":"Suraj Kumar ,&nbsp;Rishabha Malviya ,&nbsp;Sathvik Belagodu Sridhar ,&nbsp;Javedh Shareef ,&nbsp;Tarun Wadhwa","doi":"10.1016/j.medntd.2025.100369","DOIUrl":"10.1016/j.medntd.2025.100369","url":null,"abstract":"<div><div>Despite its importance, the nervous system is susceptible to impairment from strokes, severe injuries, and neurological disorders. Studies have shown that people with neurological disorders are more likely to suffer death. Substantial unfulfilled clinical demands exist because existing pharmaceutical and therapeutic approaches only alleviate symptoms and do not produce novel tissue regeneration in the central nervous system (CNS). Although there is hope for stem cell-based regeneration treatments, there are challenges to overcome, including graft rejection, expense, and ethical concerns. This review explores the potential of contemporary polymeric biomaterials for the treatment of neurological conditions. It highlights their promising application to brain tissue engineering for efficient rejuvenation and repair. To address the challenge of present therapies, neuronal tissue implementation is targeted at developing sophisticated biomaterials. <em>In-vitro</em> and <em>In-vivo</em> environments, scaffold composed of synthetic and natural polymers resembles the extracellular structure, stimulating cell proliferation and improving biological function. Several materials, including hydrogels that are made of collagen, possess the potential for regenerating damaged nerve tissue, simulating the brain's environs, and circumventing the traditional challenges of administering medications. One therapeutic approach that might be used for the management of neurodegeneration disorder is the use of polymeric scaffolds. Their potential to transform brain tissue repair and regeneration hinges on their incorporation into therapeutic procedures.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"26 ","pages":"Article 100369"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polysaccharide-derived carbon quantum dots: advances in preclinical studies, theranostic applications, and future clinical trials","authors":"Shubhrat Maheshwari ,&nbsp;Aditya Singh ,&nbsp;Amita Verma","doi":"10.1016/j.medntd.2025.100367","DOIUrl":"10.1016/j.medntd.2025.100367","url":null,"abstract":"<div><div>Polysaccharide-derived carbon quantum dots (CQDs) have emerged as promising nanomaterials, valued for their biocompatibility, low toxicity, and outstanding fluorescence characteristics, which make them ideal for diverse biomedical applications, particularly in theranostics. These carbon-based nanoparticles uniquely merge diagnostic and therapeutic capabilities, holding significant potential for both detecting and treating various diseases. Renewable and abundant polysaccharides—such as chitosan, starch, cellulose, pectin, alginate, dextran, and heparin—are excellent carbon precursors for CQD synthesis. Their inherent functional groups, like hydroxyl and carboxyl, enhance the stability, solubility, and adaptability of the resulting CQDs, broadening their application in imaging, drug delivery, and cancer treatment. Additionally, these CQDs have demonstrated potential in targeted drug delivery, controlled release systems, and tissue regeneration, solidifying their role in both diagnostic and therapeutic realms. This review examines recent progress in the synthesis of polysaccharide-derived CQDs, emphasizing preclinical studies that showcase their use in imaging, drug delivery, and cancer therapy. It further explores their prospective role in theranostic applications and outlines the challenges that must be overcome to transition these nanomaterials into clinical trials. With continued research and innovation, polysaccharide-derived CQDs are poised to contribute significantly to future clinical applications, facilitating more effective and personalized treatment strategies across a spectrum of diseases.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"26 ","pages":"Article 100367"},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in de novo protein design","authors":"Jiawei Yao,&nbsp;Xiaogang Wang","doi":"10.1016/j.medntd.2025.100366","DOIUrl":"10.1016/j.medntd.2025.100366","url":null,"abstract":"<div><div>The primary goal of protein engineering has always been to create molecules with optimal functions and characteristics. One of the most exciting avenues of research in this field is de novo protein design. This approach facilitates the synthesis of entirely new molecules without relying on existing protein, thereby offering a novel method for generating molecular entities that were previously unimaginable. The application of artificial intelligence in this field has been a significant advancement. By leveraging machine learning algorithms trained on extensive sequence and structure datasets, scientists have been able to make de novo protein design a practical reality. In this paper, we will delve into the key artificial intelligence innovations that have driven this progress and explore how they unlock groundbreaking opportunities. These advancements, we believe, have the potential to push beyond the current state of the art, enabling us to design proteins strategically and robustly. Moreover, they offer solutions to pressing societal challenges, such as developing new therapeutics, creating sustainable biomaterials, or engineering enzymes for environmental remediation.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"26 ","pages":"Article 100366"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The soft liquid metal-based pressure sensor based on resistance-capacitance coupling","authors":"Kang Sun ,&nbsp;Xinxin Zhang ,&nbsp;Shuting Liang ,&nbsp;Liangtao Li ,&nbsp;Caicai Jiao ,&nbsp;Qian Wang ,&nbsp;Wuliang Chen ,&nbsp;Liang Hu ,&nbsp;Yubo Fan","doi":"10.1016/j.medntd.2025.100363","DOIUrl":"10.1016/j.medntd.2025.100363","url":null,"abstract":"<div><div>With the rapid development of the intelligent technology, flexible sensors have widely applied in wearable electronic products, human-computer interaction, soft robots, health care and other emerging fields. At present, mechanical sensors are based on resistance or capacitance changes alone to achieve a perceived response to force. Meanwhile the methods of flexible mechanical sensors to improve the sensitivity are mainly micro-structuring of the electrode or dielectric layer, which is a complicated process and less probing of the electrode shape. Therefore, this paper proposes a flexible sensor based liquid metal to measure mechanics through resistive-capacitive coupling. Through testing, we obtained the optimal preparation scheme. We also explored the mechanical properties of the sensor design with different combinations of liquid metal electrode shapes using simulation, and then tested the mechanical properties of the double helix liquid metal sensor prepared according to the model structure. With resistive-capacitive coupling, the sensor can achieve a sensitivity of 0.4653 ​kPa⁻¹ with a response range of 10∼343 ​Pa, and it has good tensile and compressive response, and cyclic stability. This study provides a new structural design direction for the subsequent application of liquid metal in flexible sensing with high sensitivity.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"26 ","pages":"Article 100363"},"PeriodicalIF":0.0,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in rehabilitation equipment for autism spectrum disorder","authors":"Ruixiang Hou,&nbsp;Chaojuan Yang,&nbsp;Chunjing Tao,&nbsp;Yubo Fan","doi":"10.1016/j.medntd.2025.100365","DOIUrl":"10.1016/j.medntd.2025.100365","url":null,"abstract":"<div><div>Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social interaction deficits, verbal and non-verbal communication difficulties, and restricted interests and repetitive behaviors. ASD has a high morbidity and disability rate. Finding treatment approaches for autism is challenging due to the complex interplay of genetic and environmental factors that contribute to the disorder. Currently, therapeutic approaches include behavioral and pharmacological interventions, and some clinical research focuses on developing equipment for autism rehabilitation. Autism rehabilitation equipment can generally be categorized into social robots, virtual reality systems, physical stimulation devices, and augmentative and alternative communication (AAC) devices, each with different application scenarios and rehabilitation mechanisms. This article summarizes existing equipment and reviews the status of research and development in the field of autism rehabilitation, discussing the principles of the equipment and potential neural mechanisms to find breakthroughs in the treatment of ASD.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"26 ","pages":"Article 100365"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness, safety and adherence of home-based exercise rehabilitation in patients with coronary heart disease patients: A systematic review","authors":"Dong Xue ,&nbsp;Zhao Yu ,&nbsp;Li Jianchao ,&nbsp;Liu Linyi ,&nbsp;Wang Zengwu ,&nbsp;Ding Rongjing ,&nbsp;Tao Chunjing ,&nbsp;Fan Yubo","doi":"10.1016/j.medntd.2025.100361","DOIUrl":"10.1016/j.medntd.2025.100361","url":null,"abstract":"<div><div>Exercise rehabilitation is important in the home-based rehabilitation of coronary heart disease. However, a comprehensive model to assess the effectiveness, safety, and adherence of home exercise rehabilitation has not yet been established. This study aimed to synthesize and evaluate the evidence on the effectiveness, safety, and adherence of home-based exercise rehabilitation for patients with coronary heart disease. English and Chinese databases were retrieved from the inception of the database to March 1 in 2024 for HBCR and exercise. A total of 26 studies met the inclusion criteria. The main indicators to assess the effectiveness of exercise rehabilitation include: peak oxygen uptake, metabolic equivalents, 6-min walk test distance, and quality of life. The main indicators to assess the safety of exercise rehabilitation include: re-hospitalization rate, and mortality. Aerobic exercise can increase peak oxygen uptake with better safety. The main indicators for assessing adherence include the number and duration of adherent training sessions and the percentage of training completed. A comprehensive model to assess the effectiveness, safety, and adherence of home exercise rehabilitation has been established based on these indicators. Furthermore, enhancing the effectiveness necessitates high-intensity aerobic exercise. The key element ensuring the safety is the development of precise and personalized exercise prescriptions. An important trend in enhancing adherence is the integrated application of intelligent wearable technology. In the future, the home-based exercise rehabilitation will evolve towards individual precision, greater safety, and higher effectiveness.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"26 ","pages":"Article 100361"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geometric optimization of a blood pump impeller using the Taguchi method: CFD analysis and experimental evaluation","authors":"Abdoulaye Billo Diallo ,&nbsp;Rafet Yapıcı ,&nbsp;Ömer İncebay ,&nbsp;Hasan Çınar","doi":"10.1016/j.medntd.2025.100364","DOIUrl":"10.1016/j.medntd.2025.100364","url":null,"abstract":"<div><div>Rotodynamic Left Ventricular Assist Devices (LVADs) are critical in managing severe heart failure by providing mechanical circulatory support. Improving these blood pumps' efficiency is crucial for both lowering the device's energy consumption and enhancing patient comfort. In this study, the efficiency of a reference centrifugal blood pump was improved through geometric optimization and validated using computational fluid dynamics (CFD) simulations and experiments. The number of blades, inlet width, outlet width, inlet angle, and outlet angle are among the important impeller parameters that were optimized at three different levels. The orthogonal array of the Taguchi design method was used to reduce the 243 possible configurations from the full-factorial experimental design to 27 trial tests. Analysis of Variance (ANOVA) was used to determine the optimal geometric parameters, which led to maximum efficiency after S/N ratios were analyzed using MINITAB-18 software. The performance of the optimized pump was evaluated via CFD at 3300, 3150, and 3450 pump rotation speeds, resulting in a 21% increase in hydraulic efficiency at the design point (5 ​L/min, 3300 ​rpm, and 128.515 ​mm-Hg). Furthermore, experimental results demonstrated reduced power consumption for the optimized pump compared to the reference pump. This study highlights the potential of geometric optimization in advancing the performance of rotodynamic LVADs.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"26 ","pages":"Article 100364"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of physicochemical properties of polysaccharide derived mucoadhesive hydrogels to design tunable drug delivery carriers","authors":"Ankita Kumari,&nbsp;Diwanshi Sharma,&nbsp;Baljit Singh","doi":"10.1016/j.medntd.2025.100360","DOIUrl":"10.1016/j.medntd.2025.100360","url":null,"abstract":"<div><div>Recent initiatives have focused on designing copolymeric materials from bioactive polysaccharides, unveiling new horizons for their transformative use in biomedical applications. Sterculia gum (SG) is a bioactive polysaccharide which exhibits various therapeutic activities and effective in wound healing. Herein this research SG derived hydrogels were designed for wound dressing (WD) and drug delivery (DD) applications. These hydrogels were prepared by integrating PVP and HEMA onto SG by crosslinking polymerization reaction and were encapsulated with doxycycline to enhance potential of WD for healing. Copolymeric films were characterized using various techniques such as FESEM, EDS, AFM, FTIR, ¹³C NMR, XRD and various biomedical assays. Uneven porous morphology along with rough surface of hydrogels was recognized from FESEM and AFM analysis. XRD demonstrated the amorphous state of materials. FTIR and ¹³C NMR confirmed integration of PVP and PHEMA onto SG. Hydrogel exhibited bioadhesive, biocompatible and antioxidant properties. Diffusion of doxycycline followed a non-Fickian mechanism of diffusion consistent with kinetic model Korsmeyer-Peppas. The dressings were elastic and demonstrated mechanical stability during evaluation of tensile strength. Additionally, dressing displayed antimicrobial activity against <em>P. aeruginosa</em>, <em>E. coli</em>, and <em>S. aureus</em>. The biomedical properties suggested that SG derived hydrogel could be utilized in applications for WD and drug delivery.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"26 ","pages":"Article 100360"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}