Medicine in Novel Technology and Devices最新文献

{"title":"Cover","authors":"","doi":"10.1016/S2590-0935(26)00029-9","DOIUrl":"10.1016/S2590-0935(26)00029-9","url":null,"abstract":"","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"31 ","pages":"Article 100454"},"PeriodicalIF":4.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148737152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micro-needle-assisted hyaluronic acid based transdermal/local drug delivery systems for rheumatoid arthritis: Recent insights and future directions","authors":"Vrutiksinh Rathod,&nbsp;Krishna Sanka,&nbsp;Suman Rohilla,&nbsp;Mahaveer Singh","doi":"10.1016/j.medntd.2026.100451","DOIUrl":"10.1016/j.medntd.2026.100451","url":null,"abstract":"<div><div>Rheumatoid arthritis (RA) is autoimmune, inflammatory, chronic illness attacking joints and synovial membrane. RA causes progressive loss of bone erosion and cartilage destruction, resulting in reduced life expectancy, and increased mortality. Available anti-inflammatory drugs and biological molecules commonly used for treatment of rheumatoid arthritis suffer from drawbacks related to patient compliance, bioavailability and serious gastrointestinal side effects. To reduce the adverse effects associated with oral and parenteral drug delivery techniques, transdermal drug delivery systems (TDDS) are increasingly being recognized as a viable option for the management of rheumatoid arthritis (RA). Although the transdermal administration of rheumatoid arthritis drugs is hindered by suboptimal drug delivery efficacy attributable to the dense cutaneous barrier. For painless drug administration using TDDS, microneedles (MNs) are a better choice for controlled or targeted delivery of high hydrophobic and high molecular weight drugs. They can reach the deeper dermal layer, accessing the skin's dermal microcirculation for systemic and deeper local delivery. The MNs retains good mechanical strength, optimal biocompatibility and have little influence on the bioactivity of various molecules. This review imparts a comprehensive coverage about, the progress of the microneedle application in the management of RA drugs and the clinical challenges to overcome.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"31 ","pages":"Article 100451"},"PeriodicalIF":4.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148737153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiscale biomechanical and neuromuscular mechanisms underlying Achilles tendon injury","authors":"Jiakai Li,&nbsp;Yongxia Bao,&nbsp;Wentai Zhao,&nbsp;Chenxi Yan","doi":"10.1016/j.medntd.2026.100450","DOIUrl":"10.1016/j.medntd.2026.100450","url":null,"abstract":"<div><div>Achilles tendon injury is a common musculoskeletal disorder that arises from complex interactions among tissue structure, mechanical loading, neuromuscular control, and functional behavior across multiple biological scales. Therefore, a comprehensive understanding of Achilles tendon pathology requires more than a single research approach. It requires an integrative multiscale perspective that links structural, mechanical, biological, and neuromuscular mechanisms. To elucidate the mechanisms underlying Achilles tendon injury, this review systematically examined evidence from diverse research domains, including finite element modeling, animal experiments, and human movement analysis. From a computational modeling standpoint, this review synthesizes how tendon geometry, material properties, and subtendon organization shape stress-strain distributions and contribute to injury susceptibility. Experimental evidence, primarily derived from animal models, is then examined to elucidate mechanisms of load-induced degeneration and tissue repair. Finally, human-based studies are considered to evaluate how kinematic features and neuromuscular adaptations modulate the biomechanical behavior of the Achilles tendon. This review emphasizes that the integration of multiscale and multi-method approaches is essential for advancing the understanding of injury mechanisms, optimizing rehabilitation strategies, and promoting more effective interventions, thereby providing a theoretical foundation for future basic and clinical research.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"31 ","pages":"Article 100450"},"PeriodicalIF":4.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148634910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover","authors":"","doi":"10.1016/S2590-0935(26)00019-6","DOIUrl":"10.1016/S2590-0935(26)00019-6","url":null,"abstract":"","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"30 ","pages":"Article 100444"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147995739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vitro study of arterial vessel stiffness on wall shear stress reversal under physiological pulsatile flow conditions","authors":"Jianqiang Jiao,&nbsp;Yanxing Wang,&nbsp;Fangjun Shu","doi":"10.1016/j.medntd.2025.100424","DOIUrl":"10.1016/j.medntd.2025.100424","url":null,"abstract":"<div><div>This study investigates the impact of arterial stiffness on wall shear stress (WSS) reversal, a critical factor in vascular health and disease. The cardiovascular system's endothelial cells respond to mechanical stimuli, such as WSS, which influences vascular remodeling and the pathogenesis of cardiovascular diseases. Our hypothesis posits that increased arterial stiffness exacerbates WSS reversal, potentially affecting endothelial cell behavior. To test this, we conducted in-vitro experiments using transparent elastic tubings with varying stiffness to simulate arteries. A gear pump generated pulsatile flow, and 2D particle image velocimetry (PIV) was employed to measure velocity fields and calculate WSS. Our findings confirm that stiffer arteries lead to greater WSS reversal, highlighting the mechanobiological pathways linking arterial stiffness to vascular disease. The study also demonstrates that softer arteries dampen flow pulsatility, reducing the magnitude and duration of negative WSS. These results have significant implications for understanding the mechanistic pathways of vascular diseases and developing therapeutic strategies to mitigate the adverse effects of arterial stiffness. Future research should delve into the molecular mechanisms underlying endothelial responses to WSS reversal and explore potential interventions to preserve vascular health in the context of arterial stiffness. This work contributes to the growing body of evidence emphasizing the importance of mechanical forces in vascular biology and offers insights into the relationship between arterial stiffness and endothelial function.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"29 ","pages":"Article 100424"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ECMO-associated hemolysis: Advances in mechanisms and clinical management","authors":"Xinyu Liu,&nbsp;Yuan Li,&nbsp;Chenlu Wang,&nbsp;Hongyu Wang,&nbsp;Yifeng Xi,&nbsp;Anqiang Sun,&nbsp;Xiaoyan Deng,&nbsp;Zengsheng Chen,&nbsp;Yubo Fan","doi":"10.1016/j.medntd.2025.100419","DOIUrl":"10.1016/j.medntd.2025.100419","url":null,"abstract":"<div><div>Extracorporeal membrane oxygenation (ECMO) is a crucial life-support technology in critical care. However, ECMO can lead to severe complications, including hemolysis, and the underlying causes and molecular mechanisms of hemolysis are not well understood. This review systematically synthesizes prior research to elucidate hemolytic mechanisms and associated complications in ECMO therapy. We systematically investigated the effects of mechanical damage, material biocompatibility, blood component interactions, and clinical treatment on erythrocyte damage during ECMO support. This paper integrates biomechanical quantification of shear stress thresholds, and material science evaluation of surface-protein adsorption dynamics, and clinical observations of hemolysis patterns, conducted from biomechanical, material science and clinical perspectives. Based on these insights, we propose optimal ECMO design strategies and clinical measures to mitigate hemolysis. We further propose integrating intelligent biosensors, hemodynamically optimized circuits, and next-generation biomaterials to enhance real-time biocompatibility monitoring and therapeutic management.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"29 ","pages":"Article 100419"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of joint moment in lower limbs based on deep learning and multimodal data","authors":"Ronghui Cao ,&nbsp;Yuan Guo ,&nbsp;Xushu Zhang ,&nbsp;Changjiang Wang ,&nbsp;Yunpeng Wen ,&nbsp;Wenteng Liu ,&nbsp;Kai Zhang ,&nbsp;Binping Ji ,&nbsp;Weiyi Chen","doi":"10.1016/j.medntd.2025.100422","DOIUrl":"10.1016/j.medntd.2025.100422","url":null,"abstract":"<div><div>This study aimed to predict the moments at the hip, knee, and ankle joints in multiple planes during various movements. A deep learning model was developed using a bidirectional long short-term memory network (BiLSTM) combined with an agent attention mechanism (AA). Multimodal data were collected from 20 young subjects, including anthropometric data, joint angles, electromyographic signals, and ground reaction forces. The corresponding joint moments were calculated using Anybody motion simulation software. These data were used as input to the BiLSTM-AA model for joint moment prediction. Different input combinations and dimensionality reduction methods were compared. The best results were obtained by integrating anthropometric data, joint angles, and ground reaction forces. In cross-subject tests, the model showed high accuracy, with a mean absolute error of 0.0395 Nm/kg, root mean square error of 0.0579 Nm/kg, and a coefficient of determination of 0.9117. The model also performed well after reducing input dimensions. In summary, the BiLSTM-AA model predicts lower limb joint moments accurately across activities. This may simplify real-world data collection and help provide solid evidence for rehabilitation planning and assessment.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"29 ","pages":"Article 100422"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145798440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of control methods for flexible steerable needle path","authors":"Lu Yu ,&nbsp;Lizhen Wang","doi":"10.1016/j.medntd.2026.100426","DOIUrl":"10.1016/j.medntd.2026.100426","url":null,"abstract":"<div><div>Flexible steerable needle puncture is a key technique in minimally invasive surgery and has brought about significant changes in clinical surgical applications. However, precise control of the needle's path remains a central challenge, hindering its broader clinical adoption. In this review, the main obstacles in clinical path control, the uncertainty during puncture, were identified. Then, key factors influencing the needle path and methods for modeling the puncture process were summarized. The control strategies were categorized into passive control methods, active control methods, hybrid control methods, and their respective strengths and limitations were analyzed. Hybrid control methods integrate the advantages such as controllability, flexibility, security of the active and passive methods. Furthermore, emerging trends are discussed in the application of bionic structures, real-time imaging techniques, and AI driven algorithms in enhancing the controllability of flexible steerable needle and improving control accuracy and prediction.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"29 ","pages":"Article 100426"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroform Atlas single-stent coiling for wide-neck MCA bifurcation aneurysms: a retrospective single-centre case series","authors":"Zhiyong Huang ,&nbsp;Bing Huang ,&nbsp;Jianlei An ,&nbsp;Hao Sun ,&nbsp;Shuchao Chen ,&nbsp;Jiaxi Liu ,&nbsp;Dejiang Guo ,&nbsp;Lei Liu","doi":"10.1016/j.medntd.2025.100417","DOIUrl":"10.1016/j.medntd.2025.100417","url":null,"abstract":"<div><h3>Background</h3><div>Wide-neck aneurysms at the middle cerebral artery (MCA) bifurcation pose a recognized challenge for endovascular treatment. Y- or X-stent configurations can reconstruct the bifurcation but increase procedural complexity and complication risk. The Neuroform Atlas is a low-profile, open-cell stent that allows single-stent neck reconstruction through 0.0165-inch microcatheters. Evidence on its performance in Chinese patients remains limited.</div></div><div><h3>Methods</h3><div>We conducted a retrospective, single-centre case series of 15 consecutive patients with wide-neck MCA bifurcation aneurysms treated with Neuroform Atlas stent-assisted coiling at the Aviation General Hospital (Beijing, China) between October 2023 and February 2025. Inclusion criteria were aneurysm neck &gt;4 ​mm or dome-to-neck ratio &lt;1.5, age 18–75 years and ability to comply with follow-up; both ruptured (Hunt–Hess I–III) and unruptured aneurysms were included. Fourteen aneurysms were treated with a single stent and one required Y-stenting. The primary endpoint was complete occlusion (Raymond grade I) at 6-month angiographic follow-up; secondary endpoints included periprocedural thromboembolic or haemorrhagic events, functional outcome measured by the modified Rankin Scale (mRS) and the need for retreatment. Data were summarised descriptively.</div></div><div><h3>Results</h3><div>Patients had a median age of 61 years (range 30–75 years) and were predominantly female (73 ​%). Aneurysms had a median neck width of 4.2 ​mm and mean maximum diameter of 5.16 ​mm; 40 ​% presented with subarachnoid haemorrhage. Technical success was 100 ​%, with 14/15 aneurysms treated using a single stent. Immediate or follow-up angiography showed Raymond grade I occlusion in all cases. No periprocedural thromboembolic or haemorrhagic events were observed, all patients achieved mRS ≤2 ​at last follow-up, and no recurrences or retreatments were required.</div></div><div><h3>Conclusions</h3><div>In this small retrospective series, Neuroform Atlas single-stent-assisted coiling was feasible and achieved complete occlusion with no procedure-related complications in wide-neck MCA bifurcation aneurysms. These preliminary results suggest the approach may offer a safe and effective alternative to complex dual-stenting techniques, but larger prospective studies with control groups are needed to confirm its generalizability.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"29 ","pages":"Article 100417"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objective analysis of human pulse based on traditional Chinese medicine pulse matrix","authors":"Yuxin Song ,&nbsp;Xiaowei Zhao ,&nbsp;Lexin Li,&nbsp;Weijia Li,&nbsp;Bojing Shi,&nbsp;Yubo Fan","doi":"10.1016/j.medntd.2026.100429","DOIUrl":"10.1016/j.medntd.2026.100429","url":null,"abstract":"<div><div>Pulse diagnosis, an important part of Chinese traditional medicine (TCM), has developed over thousands of years and is still valued and applied worldwide. The process of pulse diagnosis necessitates extensive training and practice by physicians, necessitating the objectification of pulse diagnosis. However, the existing studies on the definition and description of pulse waveforms are incomplete, and the standards for objectification vary, which to some extent affects the further development of pulse diagnosis in TCM. In this research, a concept of pulse matrix is introduced and the definition and description of 13 pulse signals are accomplished through a literature review combined with the characterization methods in time and frequency domains, and a new method of pulse recognition based on Spearman's rank correlation coefficient is introduced. For a single pulse signal, the recognition of the pulse was completed. For continuous pulse signals, a random pulse signal generator was constructed, and the recognition of continuous pulse. Through the recognition experiments of single pulse, continuous pulse and real pulse, the effectiveness and rationality of the method are proved. It provides a promotion for the modern development of TCM pulse diagnosis. With the continuous progress of technology and the deepening of interdisciplinary cooperation, it is believed that TCM will usher in a prosperous development in the near future.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"29 ","pages":"Article 100429"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}