Medicine in Novel Technology and Devices最新文献_第2页

Estimating pulmonary arterial pressure from 4D flow images 从四维血流图像估计肺动脉压

Medicine in Novel Technology and Devices Pub Date : 2025-02-22 DOI: 10.1016/j.medntd.2025.100354

Chi Zhang , Yaowen Dong , Tongxi Liu , Jin She , Jian Yang , Deyu Li , Sheng Xie

{"title":"Estimating pulmonary arterial pressure from 4D flow images","authors":"Chi Zhang , Yaowen Dong , Tongxi Liu , Jin She , Jian Yang , Deyu Li , Sheng Xie","doi":"10.1016/j.medntd.2025.100354","DOIUrl":"10.1016/j.medntd.2025.100354","url":null,"abstract":"<div><div>The non-invasive method for estimating the pulmonary arterial pressure (PAP) plays an important role in the screening and diagnosis of pulmonary arterial hypertension (PAH). We aimed to establish a phase-contrast magnetic resonance imaging (PC-MRI) based method to estimate PAP. Through analyzing a patient's morphologic and hemodynamic features, this method could be used to identify PAH, and provide diagnostic and grading information for PAH. We selected 39 study participants, comprising 18 healthy volunteers and 21 patients with PAH. Morphologic and hemodynamic parameters of each participant's pulmonary arteries were obtained from 4D Flow images. Hemodynamic features were performed selected by principal component analysis (PCA). PAH identification model was built with binary logistic regression. Furthermore, A multiple linear regression (MLR) model was developed to estimate PAP, the accuracy of which was evaluated by comparing it with the value measured by right heart catheterization (RHC). PAH identification was achieved with high accuracy, using the features of pulmonary arterial morphology or blood flow velocity (BFV). Compared with RHC, MLR results showed that using pulmonary arterial morphology and BFV features in combination can greatly improve the accuracy of PAP estimation. Our results showed that the mean relative error of PAP estimation in PAH patients could reach <10 %. A highly accurate PC-MRI based method for PAH identification and PAP estimation was successfully established. Using hemodynamic features of the pulmonary artery could improve PAP estimation accuracy, which highlights the importance of hemodynamic evaluation of pulmonary arteries in the screening and diagnosis of PAH.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"26 ","pages":"Article 100354"},"PeriodicalIF":0.0,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in gait dynamic stability of healthy subjects due to age, body mass, height, BMI, and walking speed 年龄、体重、身高、BMI和步行速度对健康受试者步态动态稳定性的影响

Medicine in Novel Technology and Devices Pub Date : 2025-02-21 DOI: 10.1016/j.medntd.2025.100355

Anam Raza , Imran Mahmood , Tayyaba Sultana , Salma Sultana

{"title":"Differences in gait dynamic stability of healthy subjects due to age, body mass, height, BMI, and walking speed","authors":"Anam Raza , Imran Mahmood , Tayyaba Sultana , Salma Sultana","doi":"10.1016/j.medntd.2025.100355","DOIUrl":"10.1016/j.medntd.2025.100355","url":null,"abstract":"<div><div>Gait deformities are usually assessed by comparing patients' data with healthy subjects. However, the variability among healthy subjects due to age, body mass, height, BMI, and walking speed could influence the baseline data and hence rehabilitation measurements. Recent studies reported gait variability among healthy subjects considering age as a variant. The independent effect of other variants such as body mass, height, BMI, and walking speed on variability in the baseline data has remained unknown, hence investigated in this study. The centre of pressure signals collected from 205 male subjects was categorised for each of the mentioned five variants. Gait variability was evaluated in terms of walking stability. The centre of pressure signals was analysed by applying Nyquist and Bode methods to compute walking stability during the gait loading and unloading phases. A statistical comparison (one-way ANOVA, p < 0.05) revealed significant variability in the baseline data for variables (age, height, walking speed) during the loading phase and in the anterior-posterior direction. In the medial-lateral direction, these differences were observed as significant during both loading (age, body mass, speed) and unloading phases (age, body mass, height). Overall, the subgroups in respective variants i.e. age: 27 ± 0.8yr, body mass: 73 ± 0.4 kg, height: 177 ± 0.5 cm, and walking speed: 1.42 ± 0.01 m/s exhibited relatively higher stability. Further, the Pearson correlation illustrated a signification stability relationship between body mass and other variants. This study provides evidence that the diversity in the healthy subjects’ composition can cause uncertainty in diagnostic and rehabilitation measurements, which is important to consider in gait evaluations.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"26 ","pages":"Article 100355"},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corchorus olitorius (Jute) fiber enforced sustainable polymeric dressing material for antimicrobial activity 黄麻纤维增强抗菌活性的可持续高分子敷料

Medicine in Novel Technology and Devices Pub Date : 2025-02-01 DOI: 10.1016/j.medntd.2025.100352

Gupta Swati Sanjaykumar , Rishabha Malviya , Dhanalekshmi Unnikrishnan Meenakshi , Sathvik Belagodu Sridhar

{"title":"Corchorus olitorius (Jute) fiber enforced sustainable polymeric dressing material for antimicrobial activity","authors":"Gupta Swati Sanjaykumar , Rishabha Malviya , Dhanalekshmi Unnikrishnan Meenakshi , Sathvik Belagodu Sridhar","doi":"10.1016/j.medntd.2025.100352","DOIUrl":"10.1016/j.medntd.2025.100352","url":null,"abstract":"<div><div>Drug delivery to wounds has developed over time from the rudimentary administration of medication on the wound or the site of infection to more sophisticated drug delivery systems. For effectively and rapidly curing wounds, a diverse range of anti-bacterial drug delivery systems must be developed. The current study investigates the possibility of using an inexpensive and environment-friendly sustainable <em>Corchorus olitorius</em> fiber (COF) as a drug carrier for the antibacterial drug tetracycline HCl and its potential as a dressing material. The fibers were purified, grafted using acrylamide monomer, and tested for SEM, FT-IR, TGA, swelling index, swelling-de- swelling behavior, and chemical resistance. Drug loading was carried out, the highest drug loading percentage was found at 99.97 % and the formulation released medication according to the Baker-Lonsdale release kinetics pattern. The anti-microbial study showed effective inhibition of Staphylococcus aureus. The study demonstrates the successful synthesis and application of acrylamide-grafted COF loaded with tetracycline HCl, showcasing its potential as an effective wound dressing for wound care and management. Corchorus olitorius fiber is a cost-effective and eco-friendly material for preparing medicated polymeric dressings.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"25 ","pages":"Article 100352"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143297054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The history, current state and future possibilities of the non-invasive brain computer interfaces 非侵入性脑机接口的历史、现状和未来可能性

Medicine in Novel Technology and Devices Pub Date : 2025-02-01 DOI: 10.1016/j.medntd.2025.100353

Frederico Caiado, Arkadiy Ukolov

引用次数: 0

Diabetes mellitus: The pathophysiology as a canvas for management elucidation and strategies 糖尿病：病理生理学作为管理阐明和策略的画布

Medicine in Novel Technology and Devices Pub Date : 2025-01-30 DOI: 10.1016/j.medntd.2025.100351

Franklyn Nonso Iheagwam , Olawumi Toyin Iheagwam

{"title":"Diabetes mellitus: The pathophysiology as a canvas for management elucidation and strategies","authors":"Franklyn Nonso Iheagwam , Olawumi Toyin Iheagwam","doi":"10.1016/j.medntd.2025.100351","DOIUrl":"10.1016/j.medntd.2025.100351","url":null,"abstract":"<div><div>Diabetes mellitus (DM) is a progressive metabolic disease characterised by high blood glucose due to autoimmune destruction of the β-islet of Langerhans or gradual development of insulin resistance and β-cell degeneration. Numerous risk factors, from genetic to environmental, are associated with this disease. Based on the global observed cases and etiopathogenesis, DM falls into three broad categories: type 1, 2, and gestational diabetes mellitus. A comprehensive search was used to identify relevant publications using targeted keywords associated with DM, pathophysiology, medication, characterised compounds, and others across prominent databases like PubMed, Scopus, and Web of Science. This review examines how DM pathophysiology influences the type of diagnosis, screening, treatment, and management regimen that is implemented. The link between DM and some mechanistic factors and activated glucose metabolic changes is discussed. Insights on the medications targeting various DM pathophysiology mechanisms, antidiabetic mechanisms of characterised compounds from natural products and computer-aided identification of antidiabetics from natural sources are reviewed. These findings could lay the groundwork for inventive therapeutic strategies and leads from natural products based on the proper elucidation of antidiabetic mechanisms, thereby improving management and the impact of DM.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"25 ","pages":"Article 100351"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143297053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of a multiplex RT-qPCR method for the simultaneous detection of influenza type A, B and SARS-COV-2 viruses 同时检测甲型流感、乙型流感和SARS-COV-2病毒的多重RT-qPCR方法的建立和验证

Medicine in Novel Technology and Devices Pub Date : 2025-01-22 DOI: 10.1016/j.medntd.2025.100350

Samira Karimkhani , Ehsan Lotfi , Fatemeh Karamali , Mahsa DarestaniFarahani , Reza Keikha , Mahmood Barati

{"title":"Development and validation of a multiplex RT-qPCR method for the simultaneous detection of influenza type A, B and SARS-COV-2 viruses","authors":"Samira Karimkhani , Ehsan Lotfi , Fatemeh Karamali , Mahsa DarestaniFarahani , Reza Keikha , Mahmood Barati","doi":"10.1016/j.medntd.2025.100350","DOIUrl":"10.1016/j.medntd.2025.100350","url":null,"abstract":"<div><div>The study aimed to evaluate the diagnosis between SARS-COV-2 and influenza viruses using the Multiplex qPCR molecular method, highlighting the importance of these methods in disease management.</div><div>In this study, primers and probes were designed for the hemagglutinin region (HA) of influenza A, the M region of influenza B virus, and the RdRp region of SARS-COV-2. Optimization was performed using qPCR methods, and the method's analytical sensitivity and specificity were assessed. Finally, the process was compared to the commercial kit, Generi-Biotech Company (GB SARS-CoV-2 Influenza A/B).</div><div>The best annealing temperature for this method was determined to be 58 °C. Analytical sensitivity showed detection limits of 500 copies of the virus genome for SARS-CoV-2, 250 copies for influenza A, and 500 copies for influenza B. Clinical evaluations confirmed that the designed kit exhibited 100 % sensitivity and specificity, identical to the GB commercial kit, establishing its comparable diagnostic performance.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"25 ","pages":"Article 100350"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GeneXAI: Influential gene identification for breast cancer stages using XAI-based multi-modal framework GeneXAI：使用基于xai的多模态框架鉴定乳腺癌分期的影响基因

Medicine in Novel Technology and Devices Pub Date : 2024-12-27 DOI: 10.1016/j.medntd.2024.100349

Sweta Manna, Sujoy Mistry, Debashis De

{"title":"GeneXAI: Influential gene identification for breast cancer stages using XAI-based multi-modal framework","authors":"Sweta Manna, Sujoy Mistry, Debashis De","doi":"10.1016/j.medntd.2024.100349","DOIUrl":"10.1016/j.medntd.2024.100349","url":null,"abstract":"<div><div>To provide improved treatment prediction and prognosis, analysis of the categorization of cancer stages and important genes in each stage is necessary. The study introduces a GeneXAI multi-modal approach, which classifies the cancer stages and identifies the influential genes by the explainable artificial intelligence models. In the first phase of the GeneXAI, a hybrid optimal feature selection method is applied to extract the imperative features using an early fusion technique. By using the imperative features, the stages of tumor, lymph nodes, and metastasis are identified, and finally, the accurate stage of cancer is classified. In the second phase, XAI such as SHAP and LIME has been utilized to identify the best genes for distinct cancer stages. Moreover, the genomic dataset's top genes were found using SHAP, while crucial genes were found by instance using LIME. Some influential genes such as (PLA2G10, MST1R F13B, and CAMK1) identified by the GeneXAI model, have also been recognized as equally important genes in the state-of-the-art biological models. The model illustrates the process of classifying the influential genes as prognostic or non-prognostic based on their clinical importance. The proposed framework achieves an average 5–7% higher accuracy than other state-of-the-art models by using the early fusion technique of a multi-modal approach.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"25 ","pages":"Article 100349"},"PeriodicalIF":0.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CAR-T cell a potential platform for cancer therapy CAR-T细胞是癌症治疗的潜在平台

Medicine in Novel Technology and Devices Pub Date : 2024-12-17 DOI: 10.1016/j.medntd.2024.100348

Azad Kumar Maurya , Shivani Saraf , Laxmikant Gautam , Rajeev Sharma

引用次数: 0

Blastocyst cavity expansion promotes DNA methylation during early development of mouse embryos 在小鼠胚胎早期发育过程中，囊胚腔扩张促进DNA甲基化

Medicine in Novel Technology and Devices Pub Date : 2024-12-17 DOI: 10.1016/j.medntd.2024.100347

Zheng Guo, Jing Du

引用次数: 0

Cover 封面

Medicine in Novel Technology and Devices Pub Date : 2024-12-01 DOI: 10.1016/S2590-0935(24)00060-2

引用次数: 0