Medicine in Novel Technology and Devices最新文献

{"title":"Designing carrageenan-based functional biomaterials by supra-molecular and covalent interactions for biomedical applications","authors":"Nistha Thakur,&nbsp;Baljit Singh","doi":"10.1016/j.medntd.2024.100338","DOIUrl":"10.1016/j.medntd.2024.100338","url":null,"abstract":"<div><div>The present investigation is an exploration of red sea weed carrageenan (CG) to expand its horizon for biomedical applications through functionalization for sustainable development. The primary goal of the present research work was to prepare a copolymeric material by the inclusion of sulfate moieties into hydrogels through covalent and supra-molecular interactions for drug delivery (DD) applications. Copolymers were characterized by field emission-scanning electron micrographs (FESEM), electron dispersion X-ray analysis (EDAX), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), ¹³C nuclear magnetic resonance (NMR) and X-ray diffraction (XRD) instrumentation. The FESEM, AFM and XRD analysis unveiled rough heterogeneous morphology and amorphous nature of hydrogels. FTIR and ¹³C NMR confirmed inclusion of poly (AAm) and poly (VSA) onto CG by grafting and crosslinking reactions. Hydrogels demonstrated blood compatible, mucoadhesive, antioxidant and antibacterial properties. Hydrogels also revealed 179 % (Rhabdomyosarcoma) RD cell viability which indicated non-cytotoxicity to mammalian cells and promoted proliferation of cells. The release profile of the vancomycin drug followed non-Fickian diffusion and was best described by First order kinetic model. The results of physico-chemical properties demonstrated that these hydrogels have the potential for diverse biomedical applications, including DD.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100338"},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142572955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in CRISPR/Cas systems-associated surface enhanced Raman spectroscopy biosensor towards nucleic acid detection","authors":"Dongjie Zhang ,&nbsp;Siyuan He ,&nbsp;Zixu Wang ,&nbsp;Peirao Yan ,&nbsp;Huandi Li ,&nbsp;Xinyi Xu ,&nbsp;Qi Zeng ,&nbsp;Nan Wang ,&nbsp;Xueli Chen","doi":"10.1016/j.medntd.2024.100336","DOIUrl":"10.1016/j.medntd.2024.100336","url":null,"abstract":"<div><div>Nucleic acids play a decisive role in vital life processes, such as growth, heredity, and evolution, and exploring different types of nucleic acid detection techniques has always been a research hotspot worldwide. Compared to traditional nucleic acid analysis methods, surface-enhanced Raman spectroscopy (SERS) detection has advantages, such as high sensitivity, good specificity, narrow spectral bands, minimal sample requirement, simple operation, and resistance to interference from autofluorescence and water in biological samples. The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system has gained widespread attention in the fields of gene editing and biosensors. Combining the sequence-specific recognition capability of the CRISPR/Cas system with the high sensitivity fingerprinting properties of SERS technology offers a simple, rapid, and sensitive method towards nucleic acid detection. Here, common SERS Nanotags methods for nucleic acid detection are introduced, including “sandwich assay”, “signal switch assay” and HCR signal amplification. Then, the building mechanism of CRISPR-associated SERS detection is summarized. CRISPR/Cas12a activated by crRNA can recognize and lock the complementary target double-stranded DNA (dsDNA), followed by cis-cleavage of the dsDNA and trans-cleavage of the adjacent linker ssDNA. The loss of SERS signal based on aggregation is finally used for highly sensitive detection of the target DNA. Lastly, some typical applications through the integration of CRISPR/Cas and SERS technology are introduced, such as HIV-1 dsDNA, HBV DNA and AFB1 etc.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100336"},"PeriodicalIF":0.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in EEG-EMG synchronization reflecting abnormal functional corticomuscular coupling following stroke: A pilot study","authors":"Xiaoling Chen ,&nbsp;Jinyuan Zhang ,&nbsp;Yingying Hao ,&nbsp;Ying Liu ,&nbsp;Yinan Yang ,&nbsp;Ping Xie","doi":"10.1016/j.medntd.2024.100335","DOIUrl":"10.1016/j.medntd.2024.100335","url":null,"abstract":"<div><div>Stroke is a common clinical cardiovascular and cerebrovascular disease, which can cause severe motor dysfunction. Therefore, it is an important topic to investigate the abnormality mechanism of the cerebral cortex and the corresponding muscles after stroke. In this study, we investigated the functional corticomuscular coupling (FCMC) at specific frequencies by analyzing differences between stroke patients and healthy controls in hand movements. The transfer spectral entropy (TSE) method was used to analyze simultaneous electroencephalography (EEG) and electromyography (EMG) in the right-hand steady state force task. The results illustrated that healthy subjects had the highest TSE values at the beta band in the EMG→EEG and EEG→EMG directions, and the TSE value in the EEG→EMG direction was higher than that in the EMG→EEG direction. In contrast, for stroke patients, beta band coupling was weakened, and there was a notably higher enhancement of alpha and gamma bands in the EMG→EEG direction relative to the EEG→EMG direction. Further analysis found significant correlations between TSE area values at beta2 and gamma2 bands and clinical rating scales. This study demonstrates the frequency specificity properties of FCMC estimated by TSE can assess the rehabilitation status of stroke patients and contribute to our comprehension of the potential mechanism of motor control systems.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100335"},"PeriodicalIF":0.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network meta-analysis of the effect of exercise therapy on chronic neck pain","authors":"Qiang Zhao ,&nbsp;Ning Zhang ,&nbsp;Ruisu Zhang ,&nbsp;Yiming Yuan","doi":"10.1016/j.medntd.2024.100337","DOIUrl":"10.1016/j.medntd.2024.100337","url":null,"abstract":"<div><div>The purpose of this paper is to evaluate the effect of different exercise therapy on patients with chronic neck pain. By searching PubMed, EMbase, The Cochrane Library, Web of Science, CNKI, WanFang Data and other databases, we screened the literatures that met the inclusion criteria until June 2022. RCT bias risk assessment tool recommended in Cochrane manual was used to evaluate the literature quality, and Stata16.0 software was used for mesh meta-analysis. A total of 76 studies, 12 exercise therapies and 5219 participants were included. In terms of pain, Pilates [MD ​= ​−2.71,95%CI (−3.87, −1.55), P ​= ​0.000] had the most significant effect. Second training for the stability of [MD ​= ​-2.39, 95 ​% CI (−3.14, −1.64), P ​= ​0.000) and VR [MD ​= ​−2.35, 95 ​% CI (−3.6, −1.11), P ​= ​0.000). In terms of functional indexes, respiratory training [MD ​= ​−16.31,95%CI (−28.52, −4.1), P ​= ​0.009] had the most significant effect. Secondly for muscle energy technology [MD ​= ​−7.47, 95 ​% CI (−12.37, −2.58), P ​= ​0.003) and aerobic training [MD ​= ​−7.36, 95 ​% CI (−12.56, −2.16), P ​= ​0.006]. Current evidence shows that Pilates, stability training and virtual reality training are the most effective in pain intervention, muscle energy technology and comprehensive exercise training are outstanding in helping functional recovery, suggesting that appropriate exercise therapy should be implemented according to the symptoms of patients to achieve the best treatment effect.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"25 ","pages":"Article 100337"},"PeriodicalIF":0.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modelling nematic liquid crystal in fractal dimensions","authors":"Rami Ahmad El-Nabulsi","doi":"10.1016/j.medntd.2024.100334","DOIUrl":"10.1016/j.medntd.2024.100334","url":null,"abstract":"<div><div>In this paper we present a fractal Berreman's model which account for azimuthal surface anchoring of nematic liquid crystals which play a leading role nowadays in biomedical field and pharmaceutical controlled release dosage forms. The model is based on the concept of “product-like fractal measure” in anisotropic media which permits to describe liquid crystals formation in terms of fractal dimensions. It was observed that fractal dimensions affect both the polar azimuthal angle and the Franck excess elastic energy density of the distortion. For fractal dimensions close to unity, our analysis reveals the emergence of fluctuations and large deformations in the dynamical variables of the theory which suggest the presence of non-linear elastic instabilities or emergence of defect structures in liquid crystals. These fluctuations fade away for fractal dimensions much less than unity. We have evaluated the elastic energy per unit of area which is found to depend on the square of the fractal dimension. This leads to a decrease of the saturation voltage which is necessary to reduce the elastic energy of liquid crystals films in order to minimize the elastic energy. This reduction may describe nematic liquid crystals free from deformations, singularities or weak anchoring surfaces.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100334"},"PeriodicalIF":0.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-printed shoulder and elbow exercise device for stroke patients- A pilot study","authors":"Porkodi Jayavel ,&nbsp;Varshini Karthik ,&nbsp;Jaison Jacob Mathunny ,&nbsp;Suresh Jothi ,&nbsp;Ashokkumar Devaraj","doi":"10.1016/j.medntd.2024.100333","DOIUrl":"10.1016/j.medntd.2024.100333","url":null,"abstract":"<div><div>Upper limb movements are essential in everyday life; hand paralysis caused by post-stroke affects the regular lives of patients. To regain hand mobility and motor function, we must perform repetitive exercises. Nowadays, rehabilitation devices are essential to help post-stroke victims exercise and recover from paralysis more quickly. The proposed research developed a 3D-printed portable rehabilitative device for elbow and shoulder movements. This device assists patients with hand impairments in performing repetitive elbow flexion and internal/external rotation of the shoulder. Twenty post-stroke patients (each group of 10) were randomly assigned to the traditional training group or rehabilitation device training group. This study compared the outcomes of the two groups before and after eight weeks of training. Following the therapy, the patient's performance was evaluated using standard clinical tests such as the Fugl-Meyer Assessment (FMA) and Active Range of Motion (AROM) of the elbow and shoulder. The results of the RDT (Rehabilitation Device Training) group were greater than those of the TT (Traditional Training) group, and the p values (p ​&lt; ​0.05) show a significant improvement. The proposed device is a simple, low-cost, portable structure that improves muscular strength and mobility in the shoulder and elbow.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100333"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying gender differences in orbital morphology with large MRI datasets","authors":"Yingxiang Han ,&nbsp;Qi Li ,&nbsp;Tingting Liu ,&nbsp;Zengsheng Chen ,&nbsp;Xi Chen ,&nbsp;Xiaofei Wang","doi":"10.1016/j.medntd.2024.100332","DOIUrl":"10.1016/j.medntd.2024.100332","url":null,"abstract":"<div><h3>Purpose</h3><p>To investigate gender differences in orbital morphology using large MRI datasets.</p></div><div><h3>Methods</h3><p>Using a deep learning-based approach, the orbit and eyeball were automatically segmented from high resolution 3D MRI images of the IXI and OASIS3 datasets. Orbital and eyeball morphological parameters, including orbital volume, eyeball volume, effective orbital volume (EOV, defined as the orbital cavity volume excluding the eyeball), and coronal orbital dimensions and shape, were quantitatively assessed. The volume index was defined as the ratio of orbital volume to eyeball volume.</p></div><div><h3>Results</h3><p>This study included 1926 subjects with a mean age of 63.9 ​± ​15.3 years. The mean volumes of the eyeball and orbit were 7.1 ​± ​1.0 ​ml and 25.9 ​± ​3.5 ​ml, respectively. Significant gender differences (all P ​&lt; ​0.001) were observed in the following parameters (males versus females): orbital volume (28.3 ​± ​3.0 ​ml versus 24.0 ​± ​2.7 ​ml), EOV (25.1 ​± ​3.0 ​ml versus 21.1 ​± ​2.6 ​ml), eyeball volume (7.3 ​± ​1.0 ​ml versus 6.9 ​± ​1.0 ​ml), volume index (3.9 ​± ​0.6 versus 3.5 ​± ​0.5), orbital depth (40.0 ​± ​3.1 ​mm versus 37.4 ​± ​2.9 ​mm), coronal orbital height (40.8 ​± ​3.0 ​mm versus 38.4 ​± ​2.4 ​mm), coronal orbital width (38.0 ​± ​1.9 ​mm versus 36.6 ​± ​1.7 ​mm) and coronal orbital area (1292.5 ​± ​97.1 ​mm² versus 1177.9 ​± ​89.7 ​mm²).</p></div><div><h3>Conclusions</h3><p>This study employed deep learning to analyze a large dataset of 3D head MRI scans, achieving accurate and objective measurements of orbital morphology. We identified significant gender differences in orbital parameters, with males generally having larger structures. Additionally, we established a normative database for orbital dimensions, providing a valuable resource for future research on orbital disorders and potentially improving clinical diagnosis and treatment.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100332"},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000481/pdfft?md5=d7d4ebfcca38920363bf2ba466b1a9af&pid=1-s2.0-S2590093524000481-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover","authors":"","doi":"10.1016/S2590-0935(24)00045-6","DOIUrl":"10.1016/S2590-0935(24)00045-6","url":null,"abstract":"","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"23 ","pages":"Article 100329"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000456/pdfft?md5=5ee2e9eea66ecac35b597c906e18f29f&pid=1-s2.0-S2590093524000456-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of type I and II collagen in osteochondral tissue engineering: Respective features and future perspectives","authors":"Ruoyu Huang,&nbsp;Xiaolian Niu,&nbsp;Xueying Li,&nbsp;Xiaoming Li","doi":"10.1016/j.medntd.2024.100328","DOIUrl":"10.1016/j.medntd.2024.100328","url":null,"abstract":"<div><p>At present, osteoarthritis stands as one of the most prevalent degenerative musculoskeletal diseases globally. The inherent lack of self-healing capacity in articular cartilage presents a considerable obstacle in treating osteoarthritis. Tissue engineering emerged as a promising strategy for the regeneration of osteochondral defects. Collagen, a primary component of bone and cartilage, stands out as a widely utilized natural material in osteochondral tissue engineering. Among various collagen types, Type I and type II collagen are notably prominent in this field. This review initially summarizes the advantageous and disadvantageous properties of type I/II collagen in osteochondral tissue engineering, proceeds to introduce their applications in this context, and concludes with a prospective outlook on the future development of type I/II collagen's applications.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100328"},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000444/pdfft?md5=f1a3f6bb134e000bc445dff049786a89&pid=1-s2.0-S2590093524000444-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142149028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatocellular carcinoma imaging: Exploring traditional techniques and emerging innovations for early intervention","authors":"Hariharan Thirumalai Vengateswaran ,&nbsp;Mohammad Habeeb ,&nbsp;Huay Woon You ,&nbsp;Kiran Balasaheb Aher ,&nbsp;Girija Balasaheb Bhavar ,&nbsp;Govind Sarangdhar Asane","doi":"10.1016/j.medntd.2024.100327","DOIUrl":"10.1016/j.medntd.2024.100327","url":null,"abstract":"<div><p>Hepatocellular carcinoma (HCC) continues to be a diagnostic and therapeutic challenge for healthcare systems around the world in addition to being a significant contributor to oncologic mortality. To improve the standard of life and the survival of patients, early diagnosis of the condition and subsequent appropriate treatment are essential. Hepatocellular carcinoma (HCC) observation, early detection, diagnosis, and follow-up all depend heavily on imaging modalities. They provide valuable information about the characteristics of HCC nodules, aiding in non-invasive diagnosis and staging. Imaging has evolved beyond simply confirming a suspected diagnosis in the management of hepatocellular carcinoma (HCC). Several traditional imaging modalities, including PET/CT, MRI, MR elastography, ultrasound (US), and endoscopy, along with next-generation imaging modalities such as photoacoustic imaging, and Cerenkov luminescence with the utilization of contrasting agents further enhance their diagnostic capabilities in HCC. The selection of the most appropriate imaging modality and contrasting agent depends on various factors, including the clinical scenario, patient characteristics, and availability of resources. In addition to these advancements, artificial intelligence (AI) has developed as a valuable tool in radiology for the management of HCC. In this review, we highlighted the most important imaging techniques for managing patients with a high risk of HCC.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"24 ","pages":"Article 100327"},"PeriodicalIF":0.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000432/pdfft?md5=96a2ed1026601e6e818f337c6c0f729b&pid=1-s2.0-S2590093524000432-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}