Medicine in Novel Technology and Devices最新文献_第2页

Xenogeneic decellularized materials for integrated osteochondral repair 异种脱细胞材料用于骨软骨整体修复

Medicine in Novel Technology and Devices Pub Date : 2025-08-28 DOI: 10.1016/j.medntd.2025.100398

Man Wang , Yanming Ma , Rongwei Tan , Zhending She , Xiaoming Li

{"title":"Xenogeneic decellularized materials for integrated osteochondral repair","authors":"Man Wang , Yanming Ma , Rongwei Tan , Zhending She , Xiaoming Li","doi":"10.1016/j.medntd.2025.100398","DOIUrl":"10.1016/j.medntd.2025.100398","url":null,"abstract":"<div><div>Repairing osteochondral defects remains a clinical hurdle, primarily attributed to the unique hierarchical anatomical structure of osteochondral tissue and the complex structural-functional heterogeneities of the bone-cartilage interface. Conventional strategies for osteochondral defect repair, however, suffer from inherent limitations. By retaining the native extracellular matrix (ECM), decellularized constructs can recapitulate the 3D porous architecture and compositional-mechanical gradient of osteochondral tissue. Integrated xenogeneic osteochondral decellularized scaffolds have thus emerged as a research hotspot in defect repair, owing to their superior structural biomimicry and retention of native tissue bioactivity. This review first systematically outlines current osteochondral decellularization technologies and key <em>in vitro</em> evaluation indices. Furthermore, it summarizes the <em>in vivo</em> repair efficacy of such scaffolds in preclinical animal models. Ultimately, it highlights key challenges in current research, including residual immunogenicity and mismatched degradation rates of materials, and discusses the potential applications of gene editing and dynamic mechanical stimulation. This review aims to provide insights into the technological optimization and clinical translation of integrated xenogeneic osteochondral decellularized scaffolds, thereby facilitating the clinical implementation of osteochondral defect repair strategies.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"28 ","pages":"Article 100398"},"PeriodicalIF":0.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of silk fibroin incorporation on the mechanical properties and osteogenic activity of bone repair materials 丝素蛋白掺入对骨修复材料力学性能和成骨活性的影响

Medicine in Novel Technology and Devices Pub Date : 2025-08-28 DOI: 10.1016/j.medntd.2025.100399

Yingran Liu , Yanming Ma , Chao Xue , Xiaoming Li

{"title":"Effects of silk fibroin incorporation on the mechanical properties and osteogenic activity of bone repair materials","authors":"Yingran Liu , Yanming Ma , Chao Xue , Xiaoming Li","doi":"10.1016/j.medntd.2025.100399","DOIUrl":"10.1016/j.medntd.2025.100399","url":null,"abstract":"<div><div>As a natural biopolymer, silk fibroin (SF) exhibits irreplaceable value in the field of bone repair materials applications due to its excellent biocompatibility, controllable degradability, and unique structure regulation ability. The incorporation of SF can regulate various properties of bone repair materials. This paper mainly systematically reviews the effects of SF incorporation on the mechanical properties and osteogenic activity of various bone repair materials. In terms of mechanical properties, SF highly enhances the compressive strength, toughness, and structural stability of materials through the formation of β-sheet crystal structures and intermolecular interactions, effectively addressing the application limitations of traditional bone repair materials in bone tissue engineering. Meanwhile, in terms of osteogenic activity, SF can promote the adhesion, proliferation, and differentiation of mesenchymal stem cells, upregulate the expression of key markers such as alkaline phosphatase and osteocalcin by participating in signaling pathways. Especially when combined with ceramics or metal implants, it demonstrates excellent osteogenic ability. This paper will provide a theoretical framework for the creation of composite bone repair materials with precise mechanical matching and efficient osteogenic induction functions, and it has important guiding significance for promoting the clinical translation of bone tissue engineering materials.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"28 ","pages":"Article 100399"},"PeriodicalIF":0.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mouse stem cell derived-synthetic embryo models: a tool to study early embryo development 小鼠干细胞衍生的合成胚胎模型：研究早期胚胎发育的工具

Medicine in Novel Technology and Devices Pub Date : 2025-08-21 DOI: 10.1016/j.medntd.2025.100393

Jianwen Li, Zhaotong Lin, Yixuan Yao, Jing Du

引用次数: 0

Exploring the potential of In situ radiopaque bioactive glass in modern biomedical application-scope unforeseen 探索原位不透射线生物活性玻璃在现代生物医学中的应用潜力

Medicine in Novel Technology and Devices Pub Date : 2025-08-21 DOI: 10.1016/j.medntd.2025.100394

Rupam Saha , Jui Chakraborty

引用次数: 0

A hierarchical framework for cervical cell classification using attention-based multi-scale local binary convolutional neural networks 基于注意力的多尺度局部二值卷积神经网络的宫颈细胞分类层次框架

Medicine in Novel Technology and Devices Pub Date : 2025-08-14 DOI: 10.1016/j.medntd.2025.100392

Tao Wan , Lei Cao , Yulan Jin , Dong Chen , Zengchang Qin

{"title":"A hierarchical framework for cervical cell classification using attention-based multi-scale local binary convolutional neural networks","authors":"Tao Wan , Lei Cao , Yulan Jin , Dong Chen , Zengchang Qin","doi":"10.1016/j.medntd.2025.100392","DOIUrl":"10.1016/j.medntd.2025.100392","url":null,"abstract":"<div><div>Traditional classification methods for cervical cells heavily rely on manual feature extraction, constraining their versatility due to the intricacies of cytology images. Although deep learning approaches offer remarkable potential, they often sacrifice domain-specific knowledge, particularly the morphological patterns characterizing various cell subtypes during automated feature extraction. To bridge this gap, we introduce a novel hierarchical framework that integrates robust features from color, texture, and morphology with latent representations discovered by an improved attention-based multi-scale local binary convolutional neural networks (MS-LBCNN), designed to facilitate powerful feature extraction mechanism. We enhance the standard 6-class Bethesda system (TBS) classification by incorporating a coarse-to-refine fusion strategy, which optimizes the classification process. The proposed method is uniquely equipped to manage the complexities present in both individual and clustered cell images. Upon rigorous evaluation across three independent data cohorts, our method consistently surpassed existing state-of-the-art techniques. The experimental results indicated the potential of our method in enhancing the development of automation-aided diagnostic systems, and bolstering both the accuracy and efficiency of cytology screening procedures.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"27 ","pages":"Article 100392"},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic laser and haptic therapy for pain relief and muscle relaxation of forearm flexors 激光与触觉协同治疗缓解前臂屈肌疼痛及肌肉松弛

Medicine in Novel Technology and Devices Pub Date : 2025-08-07 DOI: 10.1016/j.medntd.2025.100390

Allwyn Gnanadas , Immanuvel Jashper , Muthuraj B , Sivashanmugam M

{"title":"Synergistic laser and haptic therapy for pain relief and muscle relaxation of forearm flexors","authors":"Allwyn Gnanadas , Immanuvel Jashper , Muthuraj B , Sivashanmugam M","doi":"10.1016/j.medntd.2025.100390","DOIUrl":"10.1016/j.medntd.2025.100390","url":null,"abstract":"<div><div>—In the realm of pain relief and therapy treatment, traditional single modality treatment approaches do not suffice in offering meaningful and long-lasting therapeutic effects. A modified treatment method with the laser and haptic activations within a single, hand-held device to enhance the synergistic effect during treatment is designed. It has been established that a laser, either red or infrared, is effective for promoting collagen synthesis and healing wounds by utilizing light to alter chemical and structural components at the cellular level. Alternatively, muscles are made to relax and blood flow is enhanced by apt haptic stimulation of blood circulation through proper placement of the inducing electrode. The combination therapy device merges these modalities into a ‘therapy gun’ that proves to be very effective. Though the comprehensive study and effect of the entire musculature is very cumbersome, we have focused on the most commonly used muscle groups, the flexor muscles of the forearm. The results are tested and validated using multiple biosignal study including electromyography (EMG) and endodermal activity (EDA) and the muscle load activities manipulated from the EMG. The intensity and time of treatment shall be changed depending on the patient's requirements. Post-treatment, following therapy, the EMG results showed a marked reduction in muscle activation, with an MVC of 1.350 mV and a decrease in RMS values, reflecting muscle relaxation. The PSD of the EMG signal shifted towards lower frequencies, confirming reduced muscle activity. Similarly, post-treatment EDA results demonstrated a decrease in skin conductance, with values stabilizing around 4.976 S, reflecting a return to baseline levels of physiological arousal. The histogram and PSD of the EDA signal showed a shift towards lower frequencies, consistent with the calming effects of the vibration therapy.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"27 ","pages":"Article 100390"},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144829329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the role of post-translational modifications in bone metabolism: implications for osteoporosis 揭示翻译后修饰在骨代谢中的作用：对骨质疏松症的影响

Medicine in Novel Technology and Devices Pub Date : 2025-08-06 DOI: 10.1016/j.medntd.2025.100391

Suleiman Kolawole Yusuf , Abubakar Danmaigoro , Onwuama Kenechukwu Tobechukwu , Samuel Odo Uko , Sadudeen Adetayo Amid , Okediran Babatunde Samuel , Alhaji Zubair Jaji

{"title":"Unveiling the role of post-translational modifications in bone metabolism: implications for osteoporosis","authors":"Suleiman Kolawole Yusuf , Abubakar Danmaigoro , Onwuama Kenechukwu Tobechukwu , Samuel Odo Uko , Sadudeen Adetayo Amid , Okediran Babatunde Samuel , Alhaji Zubair Jaji","doi":"10.1016/j.medntd.2025.100391","DOIUrl":"10.1016/j.medntd.2025.100391","url":null,"abstract":"<div><div>Bone metabolism is a highly dynamic process regulated by osteoblasts, osteoclasts, and osteocytes, ensuring skeletal integrity through continuous remodeling. Disruptions in this balance contribute to osteoporosis, a debilitating condition characterized by reduced bone mass and increased fracture risk. Emerging research highlights the pivotal role of post-translational modifications (PTMs) in regulating bone cell activity, influencing protein stability, function, and signaling pathways. Key PTMs, including phosphorylation, glycosylation, acetylation, ubiquitination, and SUMOylation, govern osteoblast differentiation, osteoclast activity, and extracellular matrix organization. Dysregulation of these modifications has been linked to osteoporosis pathogenesis, making them promising therapeutic targets. RUNX2, a master osteogenic transcription factor, is extensively regulated by PTMs, affecting its activity in skeletal development. Similarly, extracellular matrix proteins and osteocyte-derived factors, such as sclerostin and fibroblast growth factor 23, undergo PTMs that influence bone homeostasis. Advances in proteomics and molecular biology have facilitated the identification of PTM-mediated mechanisms, paving the way for targeted therapies, including kinase inhibitors, histone deacetylase modulators, and ubiquitination regulators. This review explores the mechanistic contributions of PTMs in bone metabolism, their dysregulation in osteoporosis, and potential therapeutic interventions, offering insights into novel strategies for bone health preservation and osteoporosis treatment.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"27 ","pages":"Article 100391"},"PeriodicalIF":0.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144878883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral hemodynamic effects of synchronizing intermittent compression with cardiac pulsation 间歇压缩与心脏搏动同步的外周血流动力学影响

Medicine in Novel Technology and Devices Pub Date : 2025-07-26 DOI: 10.1016/j.medntd.2025.100388

Chenxiao Huang , Pengyu Guo , Ruya Li , Yubo Fan

{"title":"Peripheral hemodynamic effects of synchronizing intermittent compression with cardiac pulsation","authors":"Chenxiao Huang , Pengyu Guo , Ruya Li , Yubo Fan","doi":"10.1016/j.medntd.2025.100388","DOIUrl":"10.1016/j.medntd.2025.100388","url":null,"abstract":"<div><div>Intermittent pneumatic compression (IPC) is a noninvasive therapy choice for patients with peripheral arterial diseases, which typically inflates cuffs with a fixed compression period to facilitate peripheral perfusion. The fixed compression period ignores the synergistic effect between human cardiac pulsation and external intermittent compression, limiting the potential of IPC therapy. Meanwhile, existing IPC devices cannot directly assess peripheral perfusion in the target lower limb to provide feedback for adjusting treatment parameters and improving therapeutic efficacy. This work develops a cardiac cycle-synchronous IPC prototype, featuring an innovative flexible perfusion sensor module that enables real-time synchronization of compression with local blood perfusion distribution. By continuously monitoring peripheral perfusion distribution, the system adjusts compression timing based on real-time data, offering enhanced therapeutic efficacy compared to traditional fixed-period IPC treatments. We compare the therapeutic efficacy between an asynchronous mode and three cardiac cycle-synchronous modes. The results of on-body experiments show that the systole synchronous mode outperforms other modes, significantly improving the peripheral perfusion index (PPI) and augmentation index compared to the resting state. On the control side, the PPI had no significant difference between rest and treatment phase, which suggests that IPC treatment would not damage the peripheral blood perfusion on other body parts. The developed cardiac cycle-synchronous IPC prototype demonstrates that a good synchronization between the compression and the cardiac cycle might bring better therapeutic efficacy. The proposed prototype and the exploration of cardiac cycle-synchronous IPC therapy strategies are conducive to the development of non-invasive and intelligent therapies.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"27 ","pages":"Article 100388"},"PeriodicalIF":0.0,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medicine in novel technology and devices quantitative study and evaluation of ankle joint motor-cognitive dual-task post-stroke using eye-tracking technology 应用眼动追踪技术对脑卒中后踝关节运动-认知双任务的定量研究与评价

Medicine in Novel Technology and Devices Pub Date : 2025-07-11 DOI: 10.1016/j.medntd.2025.100387

Yutong Feng , Hongbei Meng , Zihe Zhao , Xiaomeng Wang , Xiaoxue Zhai , Yansong Hu , Guanyu Wang , Bo Peng , Wenyu Yang , Xuemeng Li , Wenxin Tao , Shuo Gao , Yu Pan

{"title":"Medicine in novel technology and devices quantitative study and evaluation of ankle joint motor-cognitive dual-task post-stroke using eye-tracking technology","authors":"Yutong Feng , Hongbei Meng , Zihe Zhao , Xiaomeng Wang , Xiaoxue Zhai , Yansong Hu , Guanyu Wang , Bo Peng , Wenyu Yang , Xuemeng Li , Wenxin Tao , Shuo Gao , Yu Pan","doi":"10.1016/j.medntd.2025.100387","DOIUrl":"10.1016/j.medntd.2025.100387","url":null,"abstract":"<div><div>Dual-task ability is crucial for daily life, but sensory, cognitive, and motor impairments often reduce performance in patients, significantly impacting their quality of life. To evaluate and restore this ability, this study proposes an eye-tracking-based dual-task training system for ankle movement and cognition. The system is designed to capture and analyze real-time ankle and eye movement parameters, integrating these with traditional clinical scales to offer a multidimensional, objective, and quantitative evaluation standard. Reliability and criterion validity analyses involving 20 healthy adults and 30 stroke patients demonstrated that 88.2 % of the evaluation parameters exhibited high consistency, with 55.8 % showing a moderate correlation with clinical benchmark scales (p < 0.05). Notably, the Montreal Cognitive Assessment (MOCA), dual-task cost percentage, and TUG-subtraction task duration were identified as key indicators of dual-task ability, while the Self-Rating Anxiety Scale showed lower sensitivity. Furthermore, foot and ankle motion parameters exhibited a strong correlation with balance and fall risk, effectively serving as predictors of motor function recovery and fall risk in stroke patients. The system provides an innovative, quantitative tool for assessing lower limb dual-task ability, facilitating the identification of dual-task performance differences among stroke patients. It supports the development of evidence-based rehabilitation strategies, with the potential to enhance long-term functional recovery and improve patients' quality of life.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"27 ","pages":"Article 100387"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering nanofibers for cutaneous drug delivery systems and therapeutic applications 用于皮肤药物输送系统和治疗应用的工程纳米纤维

Medicine in Novel Technology and Devices Pub Date : 2025-07-08 DOI: 10.1016/j.medntd.2025.100386

Madhulika Pradhan , N. Saleem Basha , Kantrol Kumar Sahu , Krishna Yadav , Sucheta , Akhilesh Dubey , Hare Krishna Pradhan , John Kirubakaran

{"title":"Engineering nanofibers for cutaneous drug delivery systems and therapeutic applications","authors":"Madhulika Pradhan , N. Saleem Basha , Kantrol Kumar Sahu , Krishna Yadav , Sucheta , Akhilesh Dubey , Hare Krishna Pradhan , John Kirubakaran","doi":"10.1016/j.medntd.2025.100386","DOIUrl":"10.1016/j.medntd.2025.100386","url":null,"abstract":"<div><div>In the field of dermatological treatment and therapeutic innovation, nanofiber engineered through electrospinning technology have gained significant attention. These ultrafine structures replicate the natural framework of the extracellular environment, delivering exceptional breathability, malleability, and capacity to enhance cellular adhesion and tissue restoration. Scientists can precisely engineer these microscopic threads to administer pharmaceutical compounds with controlled released characteristics, rendering them particularly advantageous for addressing various skin conditions including lesions, eczematous inflammation, scaly erythematous plaques, follicular eruptions, and cutaneous malignancies. Incorporating antimicrobial elements, such as particulate zinc compounds and graphene-derived sheets can substantially improve their effectiveness in combating pathogenic invasion and accelerating dermal recovery. Furthermore, the electrospinning process facilitates the creation of multifunction-capable filaments with sophisticated attributes, including environment-sensitive drug release mechanisms that respond to skin surface acidity fluctuations, alongside diagnostic-therapeutic dual functionalities that permit continuous wound monitoring and assessment in clinical settings. Notwithstanding their remarkable promise, several hurdles persist in refining nanofiber architecture for bedside implementation, guaranteeing industrial-scale production capability, and executing thorough living organism investigations. This review examines cutting-edge developments in engineering nanofibers for cutaneous drug delivery systems and therapeutic applications and underscores their capacity to transform topical drug delivery systems, delivering personalized, effective, and precisely-directed treatment options.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"27 ","pages":"Article 100386"},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0