Exploring the potential of In situ radiopaque bioactive glass in modern biomedical application-scope unforeseen

Abstract

In-situ radiopaque bioactive glasses (RBG’s) have emerged as a significant advancement in biomedical applications, combining the regenerative properties of bioactive glasses with enhanced visuality under imaging modalities (X-ray, micro-CT, fluoroscopy etc.). This systematic review examines recent developments in in-situ RBG, innovations that improve further radiopacity while preserving bioactivity. The work explores the incorporation of radiopaque elements such as barium (Ba), bismuth (Bi), tantalum (Ta), zirconium (Zr) into the bioactive glass network that would be suitable for a broad spectrum biomedical application, including bone regeneration, dental restorations, and tissue embolization etc. Despite their promising potential, challenges remain in balancing radiopacity retaining bioactivity and ensuring long-term biocompatibility. The ongoing research aims to refine these materials and expand their clinical applications and potential to improve the advanced image guided treatment strategies.