Medicine in Novel Technology and Devices最新文献

{"title":"Asymmetry in circulation system and cardiovascular diseases","authors":"Chang Liu ,&nbsp;Sheng Xie ,&nbsp;Yangchen Li ,&nbsp;Da Zhang ,&nbsp;Deyu Li ,&nbsp;Chi Zhang","doi":"10.1016/j.medntd.2023.100283","DOIUrl":"10.1016/j.medntd.2023.100283","url":null,"abstract":"<div><p>Asymmetries in the human vascular system and cardiovascular disease are widespread. Vascular physiological asymmetry can manifest in the morphological structure and blood flow state, whereas pathological asymmetry can reflect differences in the occurrence and cure of bilateral vascular diseases. The causes associated with these asymmetrical differences may be demand-driven or due to vascular grading or asymmetries in other physiological systems. This article aims to review the asymmetry of several typical arteries, including cerebral, cervical, and limb arteries, and lists possible causes to emphasize the necessity of considering asymmetric factors in the prevention, treatment, and rehabilitation of vascular diseases. Future research on asymmetries in the vascular system may improve the risk assessment and personalized treatment of vascular diseases.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"21 ","pages":"Article 100283"},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093523000784/pdfft?md5=d97bbb9f3daea0288279e67b401a2b52&pid=1-s2.0-S2590093523000784-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139014729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wireless measurement of orthodontic forces in invisible aligners","authors":"Siyu Wang ,&nbsp;Bingxin Xu ,&nbsp;Xiaokang Wang ,&nbsp;Xinfang Li ,&nbsp;Bangzheng Pu ,&nbsp;Gui Chen ,&nbsp;Jianmin Han ,&nbsp;Shengzhao Xiao ,&nbsp;Yubo Fan ,&nbsp;Jiebo Li","doi":"10.1016/j.medntd.2023.100282","DOIUrl":"10.1016/j.medntd.2023.100282","url":null,"abstract":"<div><p>Invisible orthodontic treatment is an effective form of malocclusion treatment favored in recent years. The magnitude of its orthodontic force has a crucial impact on the outcome of the treatment and has gained a high level of clinical interest. However, there are very few explorations of <em>in vivo</em> measurements of orthodontic force, and existing studies are limited to a large number of couplings, which are inconvenient for clinical use. In this work, we developed a wireless flexible measurement system that allows quantitative measurement of the orthodontic force of an invisible aligner on a dental model. The system is wireless, tiny, flexible, fast responding, and has a range suitable for the range of orthodontic forces. We show the difference in the orthodontic force applied to different tooth positions and the difference in the orthodontic force applied to different positions of the same tooth. In addition, the system can evaluate the mechanical differences between aligners of different brands and materials as well as the deviation of fabrication results. This system provides a test tool and evaluation method for future real-time assessment of clinical orthodontic forces.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"21 ","pages":"Article 100282"},"PeriodicalIF":0.0,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093523000772/pdfft?md5=9b59318f68a2100e77de6391a3252417&pid=1-s2.0-S2590093523000772-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139016464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “A gyroscope-based system for intraoperative measurement of tibia coronal plane alignment in total knee arthroplasty” [Med Nov Technol Dev, 13, 2022, 100112]","authors":"Michael A. Kokko ,&nbsp;Ryan M. Chapman ,&nbsp;Martin W. Roche ,&nbsp;Douglas W. Van Citters","doi":"10.1016/j.medntd.2023.100281","DOIUrl":"https://doi.org/10.1016/j.medntd.2023.100281","url":null,"abstract":"","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"21 ","pages":"Article 100281"},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093523000760/pdfft?md5=a9765a8346aa25d0ca88715de1bb2532&pid=1-s2.0-S2590093523000760-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138582364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover","authors":"","doi":"10.1016/S2590-0935(23)00072-3","DOIUrl":"https://doi.org/10.1016/S2590-0935(23)00072-3","url":null,"abstract":"","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"20 ","pages":"Article 100277"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093523000723/pdfft?md5=7d174054aba253c40275c4622ea827b6&pid=1-s2.0-S2590093523000723-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138472119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancerous cell viability affected by synergism between electric pulses and a low dose of silver nanoparticle: An adaptive neuro-fuzzy inference system","authors":"Salim Mirshahi ,&nbsp;Behzad Vahedi ,&nbsp;Kiarash Aryana ,&nbsp;Ameneh Sazgarnia","doi":"10.1016/j.medntd.2023.100280","DOIUrl":"https://doi.org/10.1016/j.medntd.2023.100280","url":null,"abstract":"<div><p>In the current study, applying simultaneously electroporation and silver nanoparticles (SNPs) are considered. Moreover, one restriction normally assigned to such nanoparticles is their side effects on the vital organs of the body. To mitigate such deleterious effects, it is better to use lower dosages of them. However, this can result in a decline in the technique's effectiveness. To compensate for the lower dose of SNPs, one can use secondary method like electroporation to deliver SNPs directly into the cells and reinforces the effect of electric pulses due to the high electrical conductivity of SNPs while having a minimal cytotoxicity effect on normal cells that are not treated with electroporation. In the present study, synergism effects of both procedures (SNPs and electroporation) experimentally and theoretically are considered to investigate the property of each technique in increasing the performance with respect to both procedures' limitations. To investigate more, adaptive neuro-fuzzy inference system (ANFIS) is used to predict the percent cell viability of cancerous cells affected by both procedures by considering amplitude and duration as inputs affecting on change of cell viability as an output. The results obtained from both experimental and simulation procedures showed that the maximum synergism between nanoparticles and electric pulses was recorded at 700 ​V/cm strength and 100 μs duration. Also, Results indicated high correlation between observed and predicted data (r2 ​= ​0.88). Moreover, the calculated root mean square error for the results of the ANFIS model was equal to 1.1. This implies that the model has practical value and can estimate the percent cell viability of cancerous cells influenced by both procedures with varying electric field amplitude and duration. This method can be proposed for other biophysical or drug delivery applications to save time and resources by utilizing the previous experimental data rather than performing more experiments.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"21 ","pages":"Article 100280"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093523000759/pdfft?md5=026972ddab84a092ac3f41c0b55dc9a8&pid=1-s2.0-S2590093523000759-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138548862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organoid intelligence: Integration of organoid technology and artificial intelligence in the new era of in vitro models","authors":"Huaiyu Shi ,&nbsp;Andrew Kowalczewski ,&nbsp;Danny Vu ,&nbsp;Xiyuan Liu ,&nbsp;Asif Salekin ,&nbsp;Huaxiao Yang ,&nbsp;Zhen Ma","doi":"10.1016/j.medntd.2023.100276","DOIUrl":"https://doi.org/10.1016/j.medntd.2023.100276","url":null,"abstract":"<div><p>Organoid Intelligence ushers in a new era by seamlessly integrating cutting-edge organoid technology with the power of artificial intelligence. Organoids, three-dimensional miniature organ-like structures cultivated from stem cells, offer an unparalleled opportunity to simulate complex human organ systems in vitro. Through the convergence of organoid technology and AI, researchers gain the means to accelerate discoveries and insights across various disciplines. Artificial intelligence algorithms enable the comprehensive analysis of intricate organoid behaviors, intricate cellular interactions, and dynamic responses to stimuli. This synergy empowers the development of predictive models, precise disease simulations, and personalized medicine approaches, revolutionizing our understanding of human development, disease mechanisms, and therapeutic interventions. Organoid Intelligence holds the promise of reshaping how we perceive in vitro modeling, propelling us toward a future where these advanced systems play a pivotal role in biomedical research and drug development.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"21 ","pages":"Article 100276"},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093523000711/pdfft?md5=355af2f17b30ca29a63e516bf836f345&pid=1-s2.0-S2590093523000711-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138489733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of primary cilia in mechanical transmission of osteocyte based on a 3D finite element model","authors":"Zhuang Han ,&nbsp;Dong Ding ,&nbsp;Yu-bo Fan ,&nbsp;Xin-tong Wu ,&nbsp;Xiao Yang ,&nbsp;Lian-wen Sun","doi":"10.1016/j.medntd.2023.100275","DOIUrl":"https://doi.org/10.1016/j.medntd.2023.100275","url":null,"abstract":"<div><p>The primary cilium, as a mechanical receptor of osteocytes, participates in the regulation of osteocyte mechanosensitivity. However, how the length of osteocyte primary cilia changes with fluid shear stress (FSS) are unclear, and how the mechanical transmission within osteocytes altered by primary cilia is not well understood yet. Therefore, the ciliary length changes of osteocyte under 15 ​dyn/cm² of FSS were experimentally detected, and then 3D finite element models of osteocyte primary cilia containing the basal body and axoneme were built. The results showed that (1) The ciliary length of the CON group, FSS 1h, and FSS 6h were 3.71 ​± ​1.34 ​μm, 3.79 ​± ​1.04 ​μm, and 1.24 ​± ​0.73 ​μm respectively, indicating the different durations of FSS might lead to the adaptive changes of cilium length. The calculations showed (2) when the ciliary length became shorter with the ciliary angle stayed the same, the deformation and stress of the cell membrane and membrane skeleton was increased. However, the deformation and stress of the cilia membrane, basal body, the rotation angles of basal body were decreased, and those of cytoplasm, cytoskeleton, actin cortex and nucleus were also decreased; (3) With the decrease of the ciliary angle, the deformation and stress of the cilia membrane, basal body, as well as the rotation angles of basal body were increased. Those of the cytoplasm, cytoskeleton, actin cortex, and nucleus were also increased except the cell membrane and membrane skeleton. The calculation results suggested the length and angle of the primary cilia, the deformation and stress of intracellular structures in osteocyte were altered with ciliary basal body, indicated the connection between the basal body and cytoskeleton may be a key factor that affected the mechanical transport in osteocytes across the cell membrane. This finally promoted the adaptive change of ciliary length under FSS.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"21 ","pages":"Article 100275"},"PeriodicalIF":0.0,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S259009352300070X/pdfft?md5=6dd16c9aff29428904e2619952f1d42e&pid=1-s2.0-S259009352300070X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138467329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective techniques and emerging alternatives in orthodontic tooth movement: A systematic review","authors":"Rushikesh Sangle ,&nbsp;Manasvi Parab ,&nbsp;Aditya Gujare ,&nbsp;Pankaj Dhatrak ,&nbsp;Sonali Deshmukh","doi":"10.1016/j.medntd.2023.100274","DOIUrl":"10.1016/j.medntd.2023.100274","url":null,"abstract":"<div><p>Orthodontic procedures can be inconvenient in nature. To overcome this problem, accelerated orthodontics play a very important role to reduce existing trouble and discomfort. The most common inconvenience caused during orthodontic treatment procedures is that they are very time consuming which can result in several drawbacks, including an increased risk of tooth decay, gingival recession, and root resorption. Various methods can be employed to expedite orthodontic treatment by accelerating tooth movement, including surgical-assisted procedures, biological interventions, and the utilization of devices. These approaches effectively reduce the overall period of treatment. The purpose of this review is to study the effective techniques for orthodontic tooth movement as well as highlight various orthodontic accelerating methods in the respective approaches. Some non-surgical studies indicated that drug-induced methods can have a therapeutic effect on tooth movement. One of the approaches involves the local administration of Vitamin 1.25D, which has been found to expedite tooth movement. Vibrational orthodontic devices are a painless and cost-effective option that is considered the least invasive approach for accelerating tooth movement. Meanwhile, surgical approach is also a successful method, wherein great results and strong PDL tissue response were observed, but they cause a lot of pain and discomfort to the patient. Therefore, due to the strengths and limitations of each procedure covered in the study, more research should be done to identify the fastest way to speed up tooth mobility.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"20 ","pages":"Article 100274"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093523000693/pdfft?md5=54b6f4c1e4d077020e1b930ef929875d&pid=1-s2.0-S2590093523000693-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135566574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for treating adolescent depression: Study protocol for a randomized controlled trial","authors":"Jinlan Jiang ,&nbsp;Fengling Liang ,&nbsp;Zitong Xu ,&nbsp;Wei Jin ,&nbsp;Baohua Ji ,&nbsp;Lihong Li","doi":"10.1016/j.medntd.2023.100273","DOIUrl":"https://doi.org/10.1016/j.medntd.2023.100273","url":null,"abstract":"<div><p>The prevalence of depression among adolescents has been significantly increasing in recent years. However, current antidepressants for adolescents have limited safety and efficacy. Acupuncture has been shown to be effective in treating depression in adults, but there is a lack of high-quality evidence for its effect on the treatment of adolescent depression, and the underlying mechanism is still unclear. Therefore, we designed a randomized controlled trial to explore the effectiveness and the therapeutic mechanisms of acupuncture on adolescent depression. This study will be designed as a multi-center, sham and randomized controlled clinical trial. For this purpose, a total of 96 adolescent depression patients diagnosed with moderate and severe depression will be randomly divided into the manual acupuncture group and the sham one, respectively. The two groups received acupuncture treatment 3 times a week for a total course lasting 4 weeks. All patients will be assessed according to the primary outcomes including Beck Depression Inventory-II (BDI-II), Hamilton Depression Rating Scale (HAMD-24) and Zung self-rating depression scale (SDS) at baseline, week 2, 4 and 8. Additionally, the secondary outcomes will be assessed at baseline and week 4, which includes intestinal flora structure, fecal short chain fatty acids (SCFAs) content and serum serotonin (5-HT) level. This study is the first randomized trial of acupuncture treatment of adolescent depression.</p></div><div><h3>Trial registration</h3><p>Chinese Clinical Trial Registry, ChiCTR2200064359. Registered on October 4, 2022.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"20 ","pages":"Article 100273"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093523000681/pdfft?md5=07243dd4c18ea019de27ea5d647b50e8&pid=1-s2.0-S2590093523000681-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134656234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A computer vision-approach for activity recognition and residential monitoring of elderly people","authors":"Sudhir Gaikwad ,&nbsp;Shripad Bhatlawande ,&nbsp;Swati Shilaskar ,&nbsp;Anjali Solanke","doi":"10.1016/j.medntd.2023.100272","DOIUrl":"10.1016/j.medntd.2023.100272","url":null,"abstract":"<div><p>In this study, we explore a human activity recognition (HAR) system using computer vision for assisted living systems (ALS). Most existing HAR systems are implemented using wired or wireless sensor networks. These systems have limitations such as cost, power issues, weight, and the inability of the elderly to wear and carry them comfortably. These issues could be overcome by a computer vision based HAR system. But such systems require a highly memory-consuming image dataset. Training such a dataset takes a long time. The proposed computer-vision-based system overcomes the shortcomings of existing systems. The authors have used key-joint angles, distances between the key joints, and slopes between the key joints to create a numerical dataset instead of an image dataset. All these parameters in the dataset are recorded via real-time event simulation. The data set has 780,000 calculated feature values from 20,000 images. This dataset is used to train and detect five different human postures. These are sitting, standing, walking, lying, and falling. The implementation encompasses four distinct algorithms: the decision tree (DT), random forest (RF), support vector machine (SVM), and an ensemble approach. Remarkably, the ensemble technique exhibited exceptional performance metrics with 99 ​% accuracy, 98 ​% precision, 97 ​% recall, and an F1 score of 99 ​%.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"20 ","pages":"Article 100272"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S259009352300067X/pdfft?md5=d53618fe6ac4153f8e4bb0c416a9bf0b&pid=1-s2.0-S259009352300067X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135510579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}