Medicine in Novel Technology and Devices最新文献

{"title":"Geometric optimization of a blood pump impeller using the Taguchi method: CFD analysis and experimental evaluation","authors":"Abdoulaye Billo Diallo ,&nbsp;Rafet Yapıcı ,&nbsp;Ömer İncebay ,&nbsp;Hasan Çınar","doi":"10.1016/j.medntd.2025.100364","DOIUrl":"10.1016/j.medntd.2025.100364","url":null,"abstract":"<div><div>Rotodynamic Left Ventricular Assist Devices (LVADs) are critical in managing severe heart failure by providing mechanical circulatory support. Improving these blood pumps' efficiency is crucial for both lowering the device's energy consumption and enhancing patient comfort. In this study, the efficiency of a reference centrifugal blood pump was improved through geometric optimization and validated using computational fluid dynamics (CFD) simulations and experiments. The number of blades, inlet width, outlet width, inlet angle, and outlet angle are among the important impeller parameters that were optimized at three different levels. The orthogonal array of the Taguchi design method was used to reduce the 243 possible configurations from the full-factorial experimental design to 27 trial tests. Analysis of Variance (ANOVA) was used to determine the optimal geometric parameters, which led to maximum efficiency after S/N ratios were analyzed using MINITAB-18 software. The performance of the optimized pump was evaluated via CFD at 3300, 3150, and 3450 pump rotation speeds, resulting in a 21% increase in hydraulic efficiency at the design point (5 ​L/min, 3300 ​rpm, and 128.515 ​mm-Hg). Furthermore, experimental results demonstrated reduced power consumption for the optimized pump compared to the reference pump. This study highlights the potential of geometric optimization in advancing the performance of rotodynamic LVADs.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"26 ","pages":"Article 100364"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover","authors":"","doi":"10.1016/S2590-0935(25)00024-4","DOIUrl":"10.1016/S2590-0935(25)00024-4","url":null,"abstract":"","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"26 ","pages":"Article 100373"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in gait dynamic stability of healthy subjects due to age, body mass, height, BMI, and walking speed","authors":"Anam Raza ,&nbsp;Imran Mahmood ,&nbsp;Tayyaba Sultana ,&nbsp;Salma Sultana","doi":"10.1016/j.medntd.2025.100355","DOIUrl":"10.1016/j.medntd.2025.100355","url":null,"abstract":"<div><div>Gait deformities are usually assessed by comparing patients' data with healthy subjects. However, the variability among healthy subjects due to age, body mass, height, BMI, and walking speed could influence the baseline data and hence rehabilitation measurements. Recent studies reported gait variability among healthy subjects considering age as a variant. The independent effect of other variants such as body mass, height, BMI, and walking speed on variability in the baseline data has remained unknown, hence investigated in this study. The centre of pressure signals collected from 205 male subjects was categorised for each of the mentioned five variants. Gait variability was evaluated in terms of walking stability. The centre of pressure signals was analysed by applying Nyquist and Bode methods to compute walking stability during the gait loading and unloading phases. A statistical comparison (one-way ANOVA, p ​&lt; ​0.05) revealed significant variability in the baseline data for variables (age, height, walking speed) during the loading phase and in the anterior-posterior direction. In the medial-lateral direction, these differences were observed as significant during both loading (age, body mass, speed) and unloading phases (age, body mass, height). Overall, the subgroups in respective variants i.e. age: 27 ​± ​0.8yr, body mass: 73 ​± ​0.4 ​kg, height: 177 ​± ​0.5 ​cm, and walking speed: 1.42 ​± ​0.01 ​m/s exhibited relatively higher stability. Further, the Pearson correlation illustrated a signification stability relationship between body mass and other variants. This study provides evidence that the diversity in the healthy subjects’ composition can cause uncertainty in diagnostic and rehabilitation measurements, which is important to consider in gait evaluations.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"26 ","pages":"Article 100355"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomaterials and tissue engineering strategies for management of neurodegeneration: A critical perspective","authors":"Suraj Kumar ,&nbsp;Rishabha Malviya ,&nbsp;Sathvik Belagodu Sridhar ,&nbsp;Javedh Shareef ,&nbsp;Tarun Wadhwa","doi":"10.1016/j.medntd.2025.100369","DOIUrl":"10.1016/j.medntd.2025.100369","url":null,"abstract":"<div><div>Despite its importance, the nervous system is susceptible to impairment from strokes, severe injuries, and neurological disorders. Studies have shown that people with neurological disorders are more likely to suffer death. Substantial unfulfilled clinical demands exist because existing pharmaceutical and therapeutic approaches only alleviate symptoms and do not produce novel tissue regeneration in the central nervous system (CNS). Although there is hope for stem cell-based regeneration treatments, there are challenges to overcome, including graft rejection, expense, and ethical concerns. This review explores the potential of contemporary polymeric biomaterials for the treatment of neurological conditions. It highlights their promising application to brain tissue engineering for efficient rejuvenation and repair. To address the challenge of present therapies, neuronal tissue implementation is targeted at developing sophisticated biomaterials. <em>In-vitro</em> and <em>In-vivo</em> environments, scaffold composed of synthetic and natural polymers resembles the extracellular structure, stimulating cell proliferation and improving biological function. Several materials, including hydrogels that are made of collagen, possess the potential for regenerating damaged nerve tissue, simulating the brain's environs, and circumventing the traditional challenges of administering medications. One therapeutic approach that might be used for the management of neurodegeneration disorder is the use of polymeric scaffolds. Their potential to transform brain tissue repair and regeneration hinges on their incorporation into therapeutic procedures.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"26 ","pages":"Article 100369"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mass transport and fluid flow-induced wall shear stress in auxetic bone scaffolds during deformation process: a numerical study","authors":"Xuezheng Geng ,&nbsp;Nan Li ,&nbsp;Huiwen Huang ,&nbsp;Ruiqi Zhang ,&nbsp;Yan Yao ,&nbsp;Lizhen Wang ,&nbsp;Yubo Fan","doi":"10.1016/j.medntd.2025.100368","DOIUrl":"10.1016/j.medntd.2025.100368","url":null,"abstract":"<div><div>Auxetic structures exhibit an extraordinary response to mechanical forces by expanding or contracting in the transverse direction during stretching or compression, making them highly suitable for porous biomedical implants. However, their biological functions, including nutrient transport, metabolic waste removal, and cell proliferation and differentiation, remain unexplored. This study employs computational fluid dynamics (CFD) to analyze how the auxetic deformation of a scaffold influences its biological performance. An auxetic scaffold (A-scaffold) was designed alongside a non-auxetic scaffold (N-scaffold) with identical porosity (80 ​%) for comparison. Deformations at compressive strains of 0 ​%, 5 ​%, and 10 ​% were analyzed and utilized in CFD simulations to evaluate the fluid dynamics within the scaffolds. The interaction of water flow with the scaffolds was simulated, leading to predictions of mass transport and fluid flow-induced wall shear stress (WSS). Results indicated that both the fluid flow direction and scaffold architecture significantly influenced mass transport characteristics. The deformation response also impacted scaffold biological performance; specifically, the A-scaffold's concave struts hindered fluid flow in the X direction, reducing permeability but potentially promoting uniform internal fluid distribution. Although the auxetic deformation of the A-scaffold decreased its permeability, it resulted in a more irregular WSS distribution, suggesting enhanced dynamic cellular stimulation under mechanical loading. The WSS_AVG of the A-scaffold and its variation during deformation were larger in the X direction than that of the Z direction. As a result, the A-scaffold exhibited better ability to transmit mechanical stimulation in the X direction. These preliminary studies numerically characterized the mass transport properties of scaffolds under auxetic deformation for the first time, provided guidance for the design and application of an auxetic scaffold.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"26 ","pages":"Article 100368"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The soft liquid metal-based pressure sensor based on resistance-capacitance coupling","authors":"Kang Sun ,&nbsp;Xinxin Zhang ,&nbsp;Shuting Liang ,&nbsp;Liangtao Li ,&nbsp;Caicai Jiao ,&nbsp;Qian Wang ,&nbsp;Wuliang Chen ,&nbsp;Liang Hu ,&nbsp;Yubo Fan","doi":"10.1016/j.medntd.2025.100363","DOIUrl":"10.1016/j.medntd.2025.100363","url":null,"abstract":"<div><div>With the rapid development of the intelligent technology, flexible sensors have widely applied in wearable electronic products, human-computer interaction, soft robots, health care and other emerging fields. At present, mechanical sensors are based on resistance or capacitance changes alone to achieve a perceived response to force. Meanwhile the methods of flexible mechanical sensors to improve the sensitivity are mainly micro-structuring of the electrode or dielectric layer, which is a complicated process and less probing of the electrode shape. Therefore, this paper proposes a flexible sensor based liquid metal to measure mechanics through resistive-capacitive coupling. Through testing, we obtained the optimal preparation scheme. We also explored the mechanical properties of the sensor design with different combinations of liquid metal electrode shapes using simulation, and then tested the mechanical properties of the double helix liquid metal sensor prepared according to the model structure. With resistive-capacitive coupling, the sensor can achieve a sensitivity of 0.4653 ​kPa⁻¹ with a response range of 10∼343 ​Pa, and it has good tensile and compressive response, and cyclic stability. This study provides a new structural design direction for the subsequent application of liquid metal in flexible sensing with high sensitivity.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"26 ","pages":"Article 100363"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a multiplex RT-qPCR method for the simultaneous detection of influenza type A, B and SARS-COV-2 viruses","authors":"Samira Karimkhani ,&nbsp;Ehsan Lotfi ,&nbsp;Fatemeh Karamali ,&nbsp;Mahsa DarestaniFarahani ,&nbsp;Reza Keikha ,&nbsp;Mahmood Barati","doi":"10.1016/j.medntd.2025.100350","DOIUrl":"10.1016/j.medntd.2025.100350","url":null,"abstract":"<div><div>The study aimed to evaluate the diagnosis between SARS-COV-2 and influenza viruses using the Multiplex qPCR molecular method, highlighting the importance of these methods in disease management.</div><div>In this study, primers and probes were designed for the hemagglutinin region (HA) of influenza A, the M region of influenza B virus, and the RdRp region of SARS-COV-2. Optimization was performed using qPCR methods, and the method's analytical sensitivity and specificity were assessed. Finally, the process was compared to the commercial kit, Generi-Biotech Company (GB SARS-CoV-2 Influenza A/B).</div><div>The best annealing temperature for this method was determined to be 58 ​°C. Analytical sensitivity showed detection limits of 500 copies of the virus genome for SARS-CoV-2, 250 copies for influenza A, and 500 copies for influenza B. Clinical evaluations confirmed that the designed kit exhibited 100 ​% sensitivity and specificity, identical to the GB commercial kit, establishing its comparable diagnostic performance.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"25 ","pages":"Article 100350"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GeneXAI: Influential gene identification for breast cancer stages using XAI-based multi-modal framework","authors":"Sweta Manna,&nbsp;Sujoy Mistry,&nbsp;Debashis De","doi":"10.1016/j.medntd.2024.100349","DOIUrl":"10.1016/j.medntd.2024.100349","url":null,"abstract":"<div><div>To provide improved treatment prediction and prognosis, analysis of the categorization of cancer stages and important genes in each stage is necessary. The study introduces a GeneXAI multi-modal approach, which classifies the cancer stages and identifies the influential genes by the explainable artificial intelligence models. In the first phase of the GeneXAI, a hybrid optimal feature selection method is applied to extract the imperative features using an early fusion technique. By using the imperative features, the stages of tumor, lymph nodes, and metastasis are identified, and finally, the accurate stage of cancer is classified. In the second phase, XAI such as SHAP and LIME has been utilized to identify the best genes for distinct cancer stages. Moreover, the genomic dataset's top genes were found using SHAP, while crucial genes were found by instance using LIME. Some influential genes such as (PLA2G10, MST1R F13B, and CAMK1) identified by the GeneXAI model, have also been recognized as equally important genes in the state-of-the-art biological models. The model illustrates the process of classifying the influential genes as prognostic or non-prognostic based on their clinical importance. The proposed framework achieves an average 5–7% higher accuracy than other state-of-the-art models by using the early fusion technique of a multi-modal approach.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"25 ","pages":"Article 100349"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CAR-T cell a potential platform for cancer therapy","authors":"Azad Kumar Maurya ,&nbsp;Shivani Saraf ,&nbsp;Laxmikant Gautam ,&nbsp;Rajeev Sharma","doi":"10.1016/j.medntd.2024.100348","DOIUrl":"10.1016/j.medntd.2024.100348","url":null,"abstract":"<div><div>Chimeric antigen receptor (CAR) T-cell therapy has emerged as a viable treatment for various types of cancers, including B-cell lymphoma and leukemia. CAR-T cells use genetically engineered T lymphocytes that are retargeted to destroy cancer cells using Chimeric Antigen Receptor (CAR). CARs are modular synthetic receptor that consists of three major components: (1) ectodomain, (2) transmembrane domain, and (3) endo-domain. This review discussed the evolution of CAR-T cell, the mechanism of CAR T-cell for cancer treatment, and the application of CAR T-cell therapy for different types of cancer such as lung cancer, breast cancer, ovarian cancer, renal cancer, prostate cancer, pancreatic cancer, and brain cancer. At the last, we have also discussed the clinical approach and patents of CAR-T cells.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"25 ","pages":"Article 100348"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network meta-analysis of the effect of exercise therapy on chronic neck pain","authors":"Qiang Zhao ,&nbsp;Ning Zhang ,&nbsp;Ruisu Zhang ,&nbsp;Yiming Yuan","doi":"10.1016/j.medntd.2024.100337","DOIUrl":"10.1016/j.medntd.2024.100337","url":null,"abstract":"<div><div>The purpose of this paper is to evaluate the effect of different exercise therapy on patients with chronic neck pain. By searching PubMed, EMbase, The Cochrane Library, Web of Science, CNKI, WanFang Data and other databases, we screened the literatures that met the inclusion criteria until June 2022. RCT bias risk assessment tool recommended in Cochrane manual was used to evaluate the literature quality, and Stata16.0 software was used for mesh meta-analysis. A total of 76 studies, 12 exercise therapies and 5219 participants were included. In terms of pain, Pilates [MD ​= ​−2.71,95%CI (−3.87, −1.55), P ​= ​0.000] had the most significant effect. Second training for the stability of [MD ​= ​-2.39, 95 ​% CI (−3.14, −1.64), P ​= ​0.000) and VR [MD ​= ​−2.35, 95 ​% CI (−3.6, −1.11), P ​= ​0.000). In terms of functional indexes, respiratory training [MD ​= ​−16.31,95%CI (−28.52, −4.1), P ​= ​0.009] had the most significant effect. Secondly for muscle energy technology [MD ​= ​−7.47, 95 ​% CI (−12.37, −2.58), P ​= ​0.003) and aerobic training [MD ​= ​−7.36, 95 ​% CI (−12.56, −2.16), P ​= ​0.006]. Current evidence shows that Pilates, stability training and virtual reality training are the most effective in pain intervention, muscle energy technology and comprehensive exercise training are outstanding in helping functional recovery, suggesting that appropriate exercise therapy should be implemented according to the symptoms of patients to achieve the best treatment effect.</div></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"25 ","pages":"Article 100337"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}