Medicine in Novel Technology and Devices最新文献

{"title":"Targeting lipid metabolism overcomes BTK inhibitor resistance in diffuse large B-cell lymphoma","authors":"Zhuojun Liu ,&nbsp;Chenyue Wu ,&nbsp;Zhaohua Yao ,&nbsp;Yuxuan Wang ,&nbsp;Zhe Yu ,&nbsp;Jian Yu","doi":"10.1016/j.medntd.2024.100295","DOIUrl":"https://doi.org/10.1016/j.medntd.2024.100295","url":null,"abstract":"<div><p>Exploring novel therapeutic targets of Diffuse large B cell lymphoma (DLBCL) to overcome its resistance to Bruton's Tyrosine Kinase (BTK) inhibitors is a key topic. Lipid metabolism, crucial in the resistance landscape of various cancers, may unlock new aspects of BTK inhibitor resistance in DLBCL. Despite the known importance of lipid metabolism in oncological resistance patterns, its intricate role in DLBCL and its resistance to BTK inhibitor therapies remains largely uncharted. This review will explore the complex relationship between lipid metabolism and BTK inhibitor resistance, giving new insights for improving the effectiveness of BTK inhibitors and developing innovative combination treatment methods for DLBCL. This review holds the potential for guiding future research directions, optimizing existing therapeutic processes, and inspiring the development of innovative combinatorial therapeutic strategies that improve outcomes in patients with DLBCL.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"22 ","pages":"Article 100295"},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000110/pdfft?md5=37c20d3c19c6969878c0be824b5c88b7&pid=1-s2.0-S2590093524000110-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140163421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-objective structural optimization and degradation model of magnesium alloy ureteral stent","authors":"Lin Zhu ,&nbsp;Qiao Li ,&nbsp;Yuanming Gao ,&nbsp;Lizhen Wang ,&nbsp;Yubo Fan","doi":"10.1016/j.medntd.2024.100291","DOIUrl":"https://doi.org/10.1016/j.medntd.2024.100291","url":null,"abstract":"<div><h3>Background</h3><p>Mg alloys have attractive properties, including biocompatibility, biodegradability, and ideal mechanical properties. Moreover, Mg alloys are regarded as one of the promising candidates for manufacturing ureteral stents. This study proposed a multi-objective optimization method based on the Kriging surrogate model, NSGA-Ⅲ, and finite element analysis to improve the degradation performance of Mg alloy ureteral stents.</p></div><div><h3>Methods</h3><p>The finite element model for the degradation of Mg alloy ureteral stents has been established to compare the degradation performance of the stents under different parameters. Latin hypercube sampling was adopted to generate train sample points in the design space. Meanwhile, the Kriging surrogate model was constructed between strut parameters and stent degradation behavior. The NSGA-Ⅲ was utilized to determine the optimal solution in the global design space.</p></div><div><h3>Results</h3><p>The optimized stent achieved 5.52 ​× ​degradation uniformity (M), 10 ​× ​degradation time (DT), and 4 ​× ​work time (FT). The errors between the Kriging surrogate model and the finite element calculation results were less than 6%.</p></div><div><h3>Conclusion</h3><p>The optimized stent achieved better degradation performance. The degradation behavior of stents was dependent on the design parameters. The multi-objective optimization method based on the Kriging surrogate model and finite element analysis was effective in stent design optimization problems.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"22 ","pages":"Article 100291"},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000079/pdfft?md5=6c971efe78cbd24bd7d6bb065c957f36&pid=1-s2.0-S2590093524000079-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140180872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover","authors":"","doi":"10.1016/S2590-0935(24)00009-2","DOIUrl":"https://doi.org/10.1016/S2590-0935(24)00009-2","url":null,"abstract":"","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"21 ","pages":"Article 100293"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000092/pdfft?md5=9ad2d8836f5cf0dfd18c5f1b3cc7f9db&pid=1-s2.0-S2590093524000092-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current research progress on cell membrane decorated macroscopic biomaterials","authors":"Lingbing Yang,&nbsp;Linhao Li,&nbsp;Yubo Fan","doi":"10.1016/j.medntd.2024.100290","DOIUrl":"https://doi.org/10.1016/j.medntd.2024.100290","url":null,"abstract":"<div><p>The cell membranes, derived from natural sources, possesses unique physicochemical properties of phospholipid bilayers and biological functionalities of membrane proteins. This makes it an ideal biomimetic coating to enhance the <em>in vivo</em> circulation and retention time of micro/nanodrug carriers, provide targeted drug delivery effects, and neutralize bacterial toxins. Notably, recent studies have successfully coated various types of cell membranes onto the surfaces of macroscopic materials, such as electrospun fiber scaffolds and decellularized matrices, to promote tissue repair, modulate host responses to foreign materials, and alleviate inflammation. This review comprehensively summarizes the latest research progress in the modification of macroscopic biomaterials with cell membranes. The insights provided aim to serve as a valuable reference for the preparation of cell membrane biomimetic coatings and their applications in the field of tissue repair.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"21 ","pages":"Article 100290"},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000067/pdfft?md5=573e83dcaee82ffa706eab4cfcf20ba3&pid=1-s2.0-S2590093524000067-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tacrolimus combined with arsenic trioxide provides a three-in-one drug-eluting coronary stent integrating anti-restenosis, pro-endothelialization and anti-inflammation","authors":"Yaojia Zhang ,&nbsp;Hongchi Yu ,&nbsp;Li Deng ,&nbsp;Zhe Hou ,&nbsp;Jie Yang ,&nbsp;Fei Fang ,&nbsp;Michael Z. Miao ,&nbsp;Wenjun Li ,&nbsp;Xin Shen ,&nbsp;Dongyun Hao ,&nbsp;Xiaoyi Ma ,&nbsp;Lifeng Zhou ,&nbsp;Fugui He ,&nbsp;Xiaoheng Liu","doi":"10.1016/j.medntd.2024.100289","DOIUrl":"10.1016/j.medntd.2024.100289","url":null,"abstract":"<div><p>The limitations of current drug-eluting stent technologies in selectively inhibiting vascular smooth muscle cell proliferation, which often leads to inflammation, call for innovative approaches in coronary artery disease treatment. In the present work, we propose a revolutionary solution: a three-in-one platform for vascular stents, combining arsenic trioxide (ATO) and tacrolimus (TAC) to address anti-proliferation, pro-endothelialization, and anti-inflammation aspects. Our findings demonstrate that the synergistic action of ATO and TAC effectively suppresses aberrant vascular smooth muscle cell proliferation and mitigates endothelial cell inflammation. Remarkably, the combination treatment of TAC/ATO enhances endothelial cell migration and adhesion abilities. Moreover, our TAC/ATO-eluting stent exhibits superior re-endothelialization and anti-restenosis effects in a rabbit and porcine stent implantation model. Both <em>in vitro</em> and <em>in vivo</em> results solidify the notion that the TAC/ATO-eluting stent ensures rapid re-endothelialization and significantly reduces the incidence of in-stent restenosis. Overall, this study represents a promising and novel multifunctional platform with immense potential in the therapy of coronary artery disease.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"21 ","pages":"Article 100289"},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000055/pdfft?md5=74718adad9ff2263eb377d9ca1aa49b0&pid=1-s2.0-S2590093524000055-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139823128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prosthetic venous valves for chronic venous insufficiency: Advancements and future design directions","authors":"Qiushuo Zong ,&nbsp;Jing Liu ,&nbsp;Yunfei Chen ,&nbsp;Yuanyuan Kong ,&nbsp;Yiping Dang ,&nbsp;Zhihong Wang","doi":"10.1016/j.medntd.2024.100288","DOIUrl":"https://doi.org/10.1016/j.medntd.2024.100288","url":null,"abstract":"<div><p>With the serious aging population and lifestyle changes, chronic venous insufficiency accounts for approximately 25.95% of the population, which may lead to lower limb edema and leg heaviness, as well as severe infections of skin ulcers that can result in sepsis and necessitate amputation. Conservative treatment and other supportive measures can only slow the disease's progression but are unable to drastically reverse it; surgical interventions are rarely used due to the high risk of catastrophic postoperative consequences. As one of the most promising minimally invasive therapies, percutaneous prosthetic valve replacement has emerged in light of this situation, providing novel alternatives for patients with deep venous valve insufficiency. We reviewed the historical prosthetic venous valve designs, including their structure and materials, animal evaluation models, and assessment criteria. On the basis of the findings from <em>in vitro</em> tests, animal studies, and clinical trials, we summarized the major challenges and potential solutions for the development of advanced prosthetic venous valves.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"21 ","pages":"Article 100288"},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000043/pdfft?md5=b4aede50d8aff3fa8ac154df27a88dff&pid=1-s2.0-S2590093524000043-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139744300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibiting the oligomerization of mycobacterial DNA-directed RNA polymerase (RNAP) using natural compound via in-silico techniques","authors":"Ehssan H. Moglad","doi":"10.1016/j.medntd.2024.100286","DOIUrl":"10.1016/j.medntd.2024.100286","url":null,"abstract":"<div><p><em>Mycobacterium tuberculosis</em> (Mtb) is responsible for the spread of tuberculosis (TB). The current study employed virtual screening of 2569 natural compounds against the DNA-directed RNA polymerase (RNAP) of Mtb to identify the possible binders that can inhibit its function. The in-silico methodology included molecular docking to the compounds, further, the stability and flexibility of the best complexes were studied using molecular dynamics simulation, the MM/GBSA binding free energy technique with energy decomposition, PCA, FEL, steered MD simulation, and umbrella sampling. Individual virtual screenings were conducted for the five RNAP subunits (chains A, B, C, D, and E) to identify a compound capable of inhibiting RNAP oligomerization. A promising compound, isoestradiol 3-benzoate, exhibited a low binding score (−7.28 ​kcal/mol to −8.21 ​kcal/mol) and showed binding ability with all subunits of the protein. Thus, the five complexes with isoestradiol 3-benzoate were selected for molecular dynamics simulation analysis. Furthermore, RMSD showed that isoestradiol 3-benzoate bound with chain E showed the lowest RMSD of 0.49 ​nm, while with chains A and B it had the most stable and consistent conformations with RMSD of 1.75 ​nm and 1.2 ​nm, respectively. The H-bond between isoestradiol 3-benzoate and chains C and E showed the highest occupancy (58.27 ​%, 45.33 ​%, and 50.80 ​%, 42.25 ​%, 11.75 ​%). Moreover, the MMPBSA technique showed that isoestradiol 3-benzoate had a strong association with chains B and C (ΔGbind ​= ​−126.25 ​± ​2.03 and −129.27 ​± ​2.25). Additionally, free energy decomposition, PCA, FEL-steered MD simulation, and umbrella sampling were also performed to validate the association of the ligand with the protein. Isoestradiol 3-benzoate binds strongly to chains B and E; therefore, it should be considered as viable candidate for inhibiting the formation of RNAP protein complex, concluded in this study.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"21 ","pages":"Article 100286"},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S259009352400002X/pdfft?md5=e699f641cb5cbbf2309c3d938548e275&pid=1-s2.0-S259009352400002X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139631579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling functional brain connections in methamphetamine and opioid abusers","authors":"Nasimeh Marvi ,&nbsp;Javad Haddadnia ,&nbsp;Mohammad Reza Fayyazi Bordbar","doi":"10.1016/j.medntd.2024.100287","DOIUrl":"10.1016/j.medntd.2024.100287","url":null,"abstract":"<div><p>Substance abuse has become a significant problem worldwide. The primary purpose of this study was to model the functional brain connectivity in methamphetamines (Meth) and opioids (Op) groups in comparison with the healthy control (HC) group. EEG data were recorded in Meth (n ​= ​8), Op (n ​= ​12), and HC groups (n ​= ​12) in a closed-eye resting state. The NeuCube model based on a spiking neural network was used for EEG data's functional brain connectivity modeling. The NeuCube model was evaluated quantitatively and qualitatively with model descriptive parameters. The results showed the average value of the neuron's activation level, spikes emitted from neurons, and clustering coefficient as a communication parameter in the HC group decreased from 1154, 1103, 0.026 to 1036, 981, 0.020 in the Op group and to 511, 468, 0.009 in the Meth group, respectively. The changes in indices were significant according to the ANOVA test with p ≪0.001. The decrease in indices was more significant in the Meth group than in the Op group. The research findings showed that the abuse of Meth and Op causes damage to the brain's functional connections. The damage included shortening and limiting communication routes and decreased neurons' ability to generate membrane potential and emit inhibitory and excitatory spikes. Injuries were reported to be more severe in the Meth group than in the Op group.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"21 ","pages":"Article 100287"},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000031/pdfft?md5=9eae8f40adb04bcb86f9e42c3295c08c&pid=1-s2.0-S2590093524000031-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139631542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of embedded modular branched stent graft in treating aortic arch aneurysm using imaging-based computational flow analysis","authors":"Xuehuan Zhang ,&nbsp;Jiang Xiong ,&nbsp;Wei Ma ,&nbsp;Lijuan Xue ,&nbsp;Zhengyang Xu ,&nbsp;Hongpeng Zhang ,&nbsp;Yongsheng Wang ,&nbsp;Duanduan Chen ,&nbsp;Wei Guo","doi":"10.1016/j.medntd.2024.100285","DOIUrl":"10.1016/j.medntd.2024.100285","url":null,"abstract":"<div><p>Embedded modular branched stent graft (EMBSG) was a new option for aortic arch aneurysm. However, the therapeutic effect of this innovative stenting technique has not been fully assessed. Computational fluid dynamics and three-dimensional structural analyses were performed on three patients (Patient I, Patient II and Patient III) with aortic arch aneurysm, both before and after EMBSG implantation. Patient-specific alterations from preoperative to postoperative were analyzed via morphological and functional metrics. Patient I and Patient II showed notable curvature changes and area reduction after intervention procedure. Three patients showed an increase in flow velocity after EMBSG implantation, while the pressure drop from ascending aorta to the aortic arch was remarkable in Patient I and Patient II with the value of 7.09 ​mmHg, and 10.95 ​mmHg, respectively. Patient I and Patient II also showed elevated time-averaged wall shear stress (TAWSS) in the stenting region, while Patient III showed a trivial change in TAWSS after intervention procedure. Three patients showed low relative residence time after EMBSG insertion. The short-term results of EMBSG in treating aortic arch aneurysm were promising. Hemodynamic parameters have the potential to assist in the outcome evaluation and might be used to guide the stent graft design and wise selection, thereby improving the long-term therapeutic effect in managing complex vascular disease.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"21 ","pages":"Article 100285"},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000018/pdfft?md5=0748b29b9428891efb33ef3c605a1d34&pid=1-s2.0-S2590093524000018-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139637188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, optimization, and characterization of an in-situ pore-forming system for controlled delivery of paliperidone","authors":"Priya Patel,&nbsp;Bhumi Ladani,&nbsp;Gayatri Patel","doi":"10.1016/j.medntd.2023.100284","DOIUrl":"https://doi.org/10.1016/j.medntd.2023.100284","url":null,"abstract":"<div><p>The purpose of the current investigation was to develop a pharmaceutical equivalent osmotic drug delivery formulation of Paliperidone (PLD) in the form of controlled porosity osmotic pump tablets (CPOT) in order to keep the drug's steady state concentration in the body. This helps to achieve the greatest therapeutic benefit with the fewest side effects. For the purpose of identifying various formulation attributes, preliminary trials were conducted. Taguchi design was used to study the influence of seven input factors namely drug to polymer ratio, polymer 1(HPMC K100 M) to polymer 2 (HPMC K15 ​M), drug to total osmogens, coating level, amount of pore former, concentration of ethyl cellulose and amount of plasticizer on dependent variable similarity factor (f2). Utilizing the Minitab 17, data analysis was done. The similarity factor (f2) was computed using the osmotic tablet reference product INVEGA®. The findings demonstrate that each of the seven independent variables significantly affects the similarity factor. For optimized batch, both core and coated tablets showed acceptable pharmaco-technical parameters. The release profile of the optimized batch tablets was found to be similar to that of reference product with good zero-order release pattern. Drug release was observed through the channels formed by <em>in-situ</em> pores on tablet surface performed using SEM. From the results it can be concluded that prepared CPOT of PLD was found pharmaceutical equivalent with commercial product which is cost effective and fully compliance with cGMP.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"21 ","pages":"Article 100284"},"PeriodicalIF":0.0,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093523000796/pdfft?md5=0df21686790f8ee188fc011dd8182ec9&pid=1-s2.0-S2590093523000796-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139100943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}