Medicine in Novel Technology and Devices最新文献

{"title":"Designing of tragacanth gum-poly(2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide) and poly(acrylamide) based hydrogels for drug delivery and wound dressing applications","authors":"Kavita Devi ,&nbsp;Ashima Sharma ,&nbsp;Rajesh Kumar ,&nbsp;Baljit Singh","doi":"10.1016/j.medntd.2024.100303","DOIUrl":"10.1016/j.medntd.2024.100303","url":null,"abstract":"<div><p>Bioactive tragacanth gum <strong>(</strong>TG) was functionalized by covalent crosslinking of poly[2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide (PMEDSAH) to design network structure in form of hydrogel wound dressings (HWD). These copolymers were encapsulated with antibiotic drug vancomycin to enhance wound healing potential of the dressings. The copolymers were characterized by SEM, AFM, FTIR, ¹³C NMR, XRD, and TGA-DSC analysis. SEM demonstrated uneven heterogeneous morphology and AFM revealed rough surface of copolymer. Inclusion of synthetic component into HD was confirmed by FTIR and ¹³C NMR. Hydrogel dressings absorbed 8.49 ​± ​1.03 ​g/g simulated wound fluid and exhibited non-hemolytic (3.7 ​± ​0.02 % hemolytic potential) and antioxidant (37.42 ​± ​1.54 ​% free radical scavenging in DPPH assay) properties. Polymers required 35.0 ​± ​5.0 ​mN detachment force to get it detach from the mucosal surface during mucoadhesive test. Tensile strength was found to be 1.88 ​± ​0.13 ​N/mm² during mechanical stability test. Hydrogel dressings were permeable to O₂/H₂O and impermeable to microbes. Release of drug vancomycin occurred through non-Fickian diffusion mechanism and release profile was best described by Korsmeyer-Peppas kinetic model. Overall, these results revealed that these hydrogels could be explored as materials for hydrogel wound dressings.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"22 ","pages":"Article 100303"},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000195/pdfft?md5=7647ffef42380d939aa3e7c4f4905155&pid=1-s2.0-S2590093524000195-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140777107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shifts in intrinsic neural timescale of hippocampus support the maturation of inhibitory control and working memory in youth","authors":"Debin Zeng ,&nbsp;Qiongling Li ,&nbsp;Deyu Li ,&nbsp;Shuyu Li","doi":"10.1016/j.medntd.2024.100302","DOIUrl":"10.1016/j.medntd.2024.100302","url":null,"abstract":"<div><p>The intrinsic neural timescale (INT) provides temporal windows in brain activity that process information of different durations, crucial for the integration and segregation of external inputs and ultimately shaping cognition and behavior. Recent research has uncovered a pronounced INT hierarchy along the adult hippocampus's long-axis. Yet, the development of INT organization within the hippocampus—particularly the pattern of its hierarchical structure and its impact on cognitive development—has not been thoroughly investigated in youth. Here, we discovered that the INT distribution in youth presents a distinct hierarchical structure along both posterior-anterior and proximal-distal axes of the hippocampus. Strikingly, this hierarchical structure correlates significantly with the first principal gradient of the hippocampal-cortical functional connectome and the thickness of hippocampal grey matter. Furthermore, we observed notable changes in the hippocampal INT landscape during youth, characterized by a general narrowing of timescales, alongside dedifferentiation along the hippocampal organizational axes. These maturational changes significantly link to improvements in inhibitory control and working memory performance. Collectively, our findings reveal the developmental patterns of temporal integration and segregation hierarchies within hippocampus, and highlights the profound significance of INT as a neural underpinning that orchestrates cognitive growth.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"22 ","pages":"Article 100302"},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000183/pdfft?md5=7510b67c6617d21cce6107939326e3db&pid=1-s2.0-S2590093524000183-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140795627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurolithography: Lithography as an enabling technology in neurology and neuroscience","authors":"Kevin Zhai","doi":"10.1016/j.medntd.2024.100305","DOIUrl":"10.1016/j.medntd.2024.100305","url":null,"abstract":"<div><p>Modern lithography, which enables the fabrication of complex structures in biomedical devices with exceptional precision, is a potentially transformative force in the neural sciences. Techniques such as photolithography, electron beam lithography, and soft lithography have been utilized to produce devices that guide neuronal growth and differentiation and measure electrophysiological signals at the single-cell level. In the clinical sphere, lithography plays a role in the manufacturing of devices for deep brain stimulation, brain-computer interface, and neuroprosthetics. Here, we briefly review the applications of lithography in basic and translational neuroscience and clinical neurology, with an eye toward future advancement.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"22 ","pages":"Article 100305"},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000213/pdfft?md5=a2daa2735047ff88996a964aa7d999de&pid=1-s2.0-S2590093524000213-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140785458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication and evaluation of carboxymethyl guar gum-chitosan interpenetrating polymer network (IPN) nanoparticles for controlled drug delivery","authors":"Chandrani Roy ,&nbsp;Arijit Gandhi ,&nbsp;Sreejan Manna ,&nbsp;Sougata Jana","doi":"10.1016/j.medntd.2024.100300","DOIUrl":"https://doi.org/10.1016/j.medntd.2024.100300","url":null,"abstract":"<div><p>Guar gum (GG) has drawn more interest from researchers in the last several decades for the controlled delivery of drugs. The aim of the research is to fabricate and evaluate an interpenetrating polymer network (IPN) based nanocarriers system employing chemically modified GG to achieve controlled release of drug. In present study, we have reported the synthesis of carboxymethyl GG-chitosan IPN nanoparticles for controlled release of metformin hydrochloride. Carboxymethyl guar gum (CMGG) was synthesized and employed for developing IPN nanoparticles in combination with chitosan in varying polymeric ratios. A cross-linking agent, sodium tripolyphosphate (Na-TPP) was used for the synthesis of IPN colloidal suspension of nanoparticles which was lyophilized to obtain nanoparticles. The carboxymethylation of GG was confirmed through Fourier transform infra-red spectroscopy. The mean particle size was 440.6 ​nm indicating a polydispersity index of 0.528. The drug entrapment efficiency was found to vary between 67.46 ​± ​1.64 ​% to 88.23 ​± ​2.02 ​%. The differential scanning calorimetry study revealed the presence of amorphous metformin hydrochloride as a homogenous dispersion in nanoparticles (NPs) matrix. <em>In vitro</em> drug release study indicated controlled release ability of developed IPN matrix. A2 formulation (chitosan:CMGG -1:1) exhibited 78.11 ​± ​0.27 ​% release after 8 ​h. Antidiabetic evaluation performed in alloxan-treated diabetic rat model exhibited a prolonged hypoglycemic efficacy over 6 ​h, for A2 formulation treated group, compared to the group receiving only metformin HCl, which demonstrated a reduction in blood glucose levels for up to 4 ​h. The study findings demonstrated the efficacy of the CMGG-chitosan based IPN nanoparticulate system for sustained delivery of therapeutic agents.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"22 ","pages":"Article 100300"},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S259009352400016X/pdfft?md5=81956995cf04f5423ce2a618d45d61f0&pid=1-s2.0-S259009352400016X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140638548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biophysical cues involved in the stem cell niche for stemness maintenance","authors":"Chiyu Li,&nbsp;Lisha Zheng,&nbsp;Yubo Fan","doi":"10.1016/j.medntd.2024.100301","DOIUrl":"https://doi.org/10.1016/j.medntd.2024.100301","url":null,"abstract":"<div><p>The characteristics of stem cells are self-renewal ability and differentiation potential. These properties are defined as stemness, offering them application in tissue repair and regeneration based on stem cells with great promise. However, stem cells undergo functional deterioration and gradually lose stemness with long-term expansion. Accumulating evidence implies that the regulation of stemness is primarily orchestrated by the niche, which comprises the connection between stem cells and niche cells, extracellular matrix (ECM) proteins, and secreted factors. Increasingly, physical signals are being acknowledged as paramount regulators of cellular behavior, governing stem cell stemness, tissue development, and regeneration. This review outlines current approaches for stemness maintenance and the important biophysical cues involved in the stem niche. We first encompass the latest discoveries regarding the sources and transduction pathways of these biophysical cues. Subsequently, the specific biophysical factors for regulating stemness have been described. Moreover, we summarize existing challenges and prospect future research in this field.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"22 ","pages":"Article 100301"},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000171/pdfft?md5=2af893d2d65fe30ba764c24a2b4c39ef&pid=1-s2.0-S2590093524000171-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140638549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation into the analysis method for assessing contact stress in joint prosthesis","authors":"Weiling Cui ,&nbsp;Xushu Zhang ,&nbsp;Weiyi Chen ,&nbsp;Ji Qiu","doi":"10.1016/j.medntd.2024.100299","DOIUrl":"https://doi.org/10.1016/j.medntd.2024.100299","url":null,"abstract":"<div><p>Contact stress is the important cause of wear and failure of knee joint prostheses implanted in the human body during movement. The calculation of contact stress on joint prostheses is often inaccurate due to the deviation of joint position during activity. This paper proposes a correction method for contact stress based on finite element results. Firstly, the contact stress and contact radius between femoral and tibial prostheses of knee joint were calculated and analyzed by Hertz contact theory. Then, individualized finite element models based on the individualized geometry of the joint prosthesis and individualized loading were constructed, and the finite element contact stress was analyzed. The finite element results were calibrated utilizing the Hertz contact theory. Additionally, this study investigated the impact of three gait patterns (normal gait, medial thrust gait, and bouncing gait) on the contact stress experienced by the tibial insert. The research methods and results can provide ideas for theoretical analysis and finite element simulation of prosthetic joint contact, as well as offer theoretical support and analysis methods for evaluating the lifespan of prosthetic joints.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"22 ","pages":"Article 100299"},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000158/pdfft?md5=a5d7f8bec5a2fcf56be09999ee5837c1&pid=1-s2.0-S2590093524000158-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140350108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical analysis of bone mesoscopic structure and mechanical properties of vertebral endplates of degenerated intervertebral discs in rabbits","authors":"Bingying Zhao ,&nbsp;Yuan Guo ,&nbsp;Xushu Zhang ,&nbsp;Yibo Zhao ,&nbsp;Bin Zhao ,&nbsp;Ming Zhang","doi":"10.1016/j.medntd.2024.100298","DOIUrl":"10.1016/j.medntd.2024.100298","url":null,"abstract":"<div><p>In previous studies of disc degeneration, the structural and mechanical properties of the endplate were often neglected. In this paper, the station legislation was used to construct an animal model of minor trauma disc degeneration, and the mechanism of disc degeneration was further investigated by observing the changes of mesoscopic structure and developing the mechanical properties of endplate bone.</p><p>Twenty-eight 6-month-old Japanese white rabbits were divided into two groups: control group and experimental group. An animal model of intervertebral disc degeneration was established by upright experiment in the experimental group. The bone mesoscopic structures in different areas of each endplate were observed by histological and imaging methods, and the mechanical properties of the endplates were measured by indentation method. The two groups of data were compared by one-way ANOVA.</p><p>After the experimental animals stood for 17 weeks, The experimental group showed the characteristics of early disc degeneration. The microstructure of the degenerative group showed that the end plate mineralization degree was higher, the bone mass was larger, and the number and thickness of bone trabeculae were larger. The results of indentation test showed that the mechanical properties of the degeneration group were enhanced, and the lower endplate was obviously enhanced.</p><p>We successfully established a model of human disc degeneration with non invasive trauma and more consistent with the process of human disc degeneration through the standing experiment. In the experimental group, the internal structure of the endplate was dense and pore distance was reduced. The change of bone mesoscopic structure further affects the endplate, resulting in the enhancement of the mechanical properties of the endplate after intervertebral disc degeneration. The reduction of the pore distance and the narrowing of the internal channel structure of the endplate also hinder the nutrition supply of the intervertebral disc, which may be the key reason affecting the degeneration of the intervertebral disc. A biomechanical method for investigating the mechanism of intervertebral disc degeneration can be provided in this paper.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"22 ","pages":"Article 100298"},"PeriodicalIF":0.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000146/pdfft?md5=228fb730b8993b68bb3649eb2b2437d0&pid=1-s2.0-S2590093524000146-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140405210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An efficient tool for Parkinson's disease detection and severity grading based on time-frequency and fuzzy features of cumulative gait signals through improved LSTM networks","authors":"Farhad Abedinzadeh Torghabeh ,&nbsp;Yeganeh Modaresnia ,&nbsp;Seyyed Abed Hosseini","doi":"10.1016/j.medntd.2024.100297","DOIUrl":"https://doi.org/10.1016/j.medntd.2024.100297","url":null,"abstract":"<div><p>Parkinson's disease (PD) is a widespread neurodegenerative condition that affects many individuals annually. Early identification and monitoring of disease progression are crucial to effectively managing symptoms and preventing motor complications. This research proposes an automated PD diagnosis and severity-grading model based on time-frequency and fuzzy features using improved uni-directional and bi-directional long short-term memory networks with sensitive hyperparameters optimization. We utilize vertical ground reaction force signals collected from Physionet's publicly available dataset recorded during regular and dual-task clinical trials of walking measurements. Only the cumulative signal of both feet was then utilized and segmented into 30-s windows without further pre-processing. Subsequently, we extracted only four key time-frequency and fuzzy features from each segment, effectively capturing the signal's inherent uncertainty. Bayesian optimization is employed in both detection and grading approaches to fine-tune the two critical hyperparameters: the initial learning rate and the number of hidden units in the network. The detection phase yields an exceptional accuracy of 99.19%, surpassing state-of-the-art studies with the same dataset. In the grading phase, classification based on the unified PD rating scale values achieves an accuracy of 92.28%. The proposed study delves into the potential of cumulative gait signals as a powerful diagnostic tool for PD, aiming to extract precise and intricate information by implementing straightforward and minimal processing endeavors. This method demonstrates significant efficiency in terms of complexity, cost, and energy consumption by utilizing a single-dimensional signal, eliminating the need for pre-processing steps, and limiting the features used for training.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"22 ","pages":"Article 100297"},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000134/pdfft?md5=5c0b4f76dbd5a673bee5484ac69ac22d&pid=1-s2.0-S2590093524000134-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140347293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential application of formulation with pimelic acid as eye drops for corneal collagen cross-linking","authors":"Daishi Chen ,&nbsp;Di Jiang ,&nbsp;Zhaoyang Ke","doi":"10.1016/j.medntd.2024.100296","DOIUrl":"10.1016/j.medntd.2024.100296","url":null,"abstract":"<div><h3>Background and aim</h3><p>Keratoconus is a slowly progressive and non-inflammatory disease of eye of unknown etiology characterized by significant structural degeneration, thinning and protrusion of cornea. Collagen cross linking using Riboflavin/ultraviolet A, paraformaldehyde and glutaraldehyde has been widely used to treat keratoconus, but these techniques have several clinical complications. This study aimed to develop a rapid, safer, less toxic and more effective method to increase the corneal stiffness hence treating keratoconus by using EDC/NHS coupling with pimelic acid (PA) as cross-linkers.</p></div><div><h3>Methods</h3><p>The viability of corneal epithelial and endothelial cells was examined using Alamar blue. The corneal collagen and tissue integrity were evaluated with Masson and hematoxylin and eosin stains respectively. Uniaxial tensile testing was conducted to determine the tissue stiffness. We further assessed the effective penetration depth of cross-linking by fluorescence dye and confocal microscopy. TUNEL assay was performed to detect the damaged DNA fragments in the presence of PA.</p></div><div><h3>Results</h3><p>The effect of PA solution on corneal cross-linking showed a significant increase in corneal rigidity without affecting the epithelium integrity under neutralized pH condition, while DEC/NHS alone did not induce the mechanical property. The penetration depth showed consistent results with increased stiffness, which could be affected by the parameters including pH condition, coupling with or without PA. In addition, PA significantly decreased the percentage of TUNEL-positive cells compared to that of EDC/NHS only condition. The cytotoxic effect to endothelium was considered minimal and protected in the presence of PA.</p></div><div><h3>Conclusions</h3><p>We demonstrated PA as a potential alternative for cross-linking in the model of whole eye with intact epithelium and its protective role on endothelium. The administration of this chemical cross-linker stands as an extremely promising technique for the treatment of corneal keratoconus.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"22 ","pages":"Article 100296"},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000122/pdfft?md5=35b3bda20f8882c1524de77c8d96de7d&pid=1-s2.0-S2590093524000122-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140273918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent development of aspiration pump in the aspiration thrombectomy system","authors":"Chen Wei ,&nbsp;Jing Dong ,&nbsp;Hongyi Yang ,&nbsp;Jinghong Shi ,&nbsp;Huihui Fang ,&nbsp;Yangjie Zuo ,&nbsp;Yubing Shi","doi":"10.1016/j.medntd.2024.100292","DOIUrl":"https://doi.org/10.1016/j.medntd.2024.100292","url":null,"abstract":"<div><p>Vascular embolic diseases are associated with blockage of blood supply to vital organs and thus are lethal. Aspiration thrombectomy is becoming the primary choice for revascularization in the treatment of vascular occlusions condition. As the power source in the aspiration thrombectomy procedure, the aspiration pump directly influences the outcome of the operation. This research surveyed the current technical developments of the aspiration pump in China through reviewing information obtained from the patent database and technical literatures, commented on the issues in the current patent designs, and gave suggestions for future design improvement. This study can be used as a reference for researchers and developers of medical devices besides the neurosurgeons.</p></div>","PeriodicalId":33783,"journal":{"name":"Medicine in Novel Technology and Devices","volume":"22 ","pages":"Article 100292"},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590093524000080/pdfft?md5=ec22c8eee3987d7fc5b2193a9d25d608&pid=1-s2.0-S2590093524000080-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140159949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}