International Journal of Biological Macromolecules最新文献

{"title":"Biogenic fabrication of bovine serum albumin nanoparticles using Sargassum aquifolium extract: Optimization, physicochemical characterization, and preliminary in vitro scratch-closure evaluation.","authors":"Noura El-Ahmady El-Naggar, Aly Samy Alashry, Amira Mohamed Kamal, Esraa Mustafa Selim, Esraa Taha ElSaeedy, Ehap Ashraf Awad, Omnia Ebrahim Elhoseiny, Nada Salah Ellithy","doi":"10.1016/j.ijbiomac.2026.154868","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.154868","url":null,"abstract":"<p><p>Albumin nanostructures are attractive biomedical platforms because of their biocompatibility, low toxicity, biodegradability, and functional versatility. In this study, bovine serum albumin nanoparticles (BSA-NPs) were fabricated through a green route using a hot-water extract of Sargassum aquifolium as a source of biomolecules potentially involved in nanoparticles assembly. GC-FID analysis of the dried algal extract identified nine fatty acid methyl esters, predominantly methyl palmitate (42.33%), methyl oleate (17.94%), and methyl stearate (15.17%). FTIR spectra indicated spectral shifts associated with interactions between BSA and algal-derived biomolecules during nanoparticles formation. TEM showed predominantly spherical to quasi-spherical BSA-NPs ranging from 9 to 53 nm, with a mean diameter of 26.85 ± 9.89 nm. DLS yielded a Z-average of 228.5 nm, while the zeta potential was -34 mV, indicating a negatively charged surface and appreciable electrostatic stabilization under the measurement conditions. Numerical optimization identified pH 7, BSA concentration of 7500 μg/mL, and an incubation time of 48 h as the optimal conditions, with a predicted BSA-NPs yield of 3942.41 μg/mL. Experimental validation yielded 3952 μg/mL, demonstrating close agreement with the predicted value. Preliminary scratch-closure responses were evaluated in HFB4 cells after 24 h. At 75 μg/mL, closure was 84.95% with BSA-NPs, 78.02% with native BSA, and 69.14% for the corresponding untreated control. At 300 μg/mL, both BSA-NPs and native BSA produced 100% closure, compared with 64.45% in the corresponding control. These findings demonstrate the feasibility of Sargassum aquifolium-assisted green fabrication of BSA-NPs and provide preliminary evidence of their in vitro scratch-closure activity, that merits further biological investigation.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"154868"},"PeriodicalIF":8.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Starch-enabled electrospinning and aqueous activation for ultrahigh surface area, heteroatom-doped carbon nanofibers for high-performance supercapacitors.","authors":"Zongyao Zhu, Hongjie Wang, Fangtao Ruan, Hongmei Zuo, Quan Feng, Lingjian Zhang, Weiwei Li, He Wang","doi":"10.1016/j.ijbiomac.2026.154884","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.154884","url":null,"abstract":"<p><p>Starch-based carbon nanofibers hold great promise for sustainable supercapacitor electrodes due to the natural abundance and renewability of starch. However, transforming starch into carbon nanofibers remains challenging because of its poor thermal stability, which often leads to structural collapse during thermal treatment. Herein, we propose a ternary polymer strategy (starch/PAN/PMMA) to overcome this limitation, enabling successful electrospinning while preserving structural integrity. Notably, starch serves a dual function as a renewable carbon source and, more importantly, an enabler for a green aqueous activation process. The fibrous network takes up the aqueous KOH/thiourea solution mainly through capillary action, while the hydroxyl groups of starch provide additional water affinity at the molecular level. This allows uniform impregnation of the precursor fibers and achieves simultaneous chemical activation and in-situ N/S doping in a single step, without organic solvents or complex pre-drying. The resulting hierarchically porous carbon nanofibers exhibit an ultrahigh specific surface area of 1952.30 m²/g and deliver a specific capacitance of 517.5 F/g at 0.5 A/g, an energy density of 23.25 Wh/kg, and 97.58% capacitance retention after 10,000 cycles at 5-10 A/g. This work unlocks the potential of starch for high-performance energy storage through a safer, more sustainable aqueous activation route.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"154884"},"PeriodicalIF":8.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zein-based hybrid nanocarriers for non-viral gene delivery: A review.","authors":"Dua Alsinglawi, Enass Serry Moursy, Bilgesu Kasurka, Zainab Al-Quraishi, Vanessa Gi San Ho, Christine Dufès","doi":"10.1016/j.ijbiomac.2026.154850","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.154850","url":null,"abstract":"<p><p>Gene therapy and RNA-based therapeutics are increasingly limited by the challenge of delivering fragile, anionic nucleic acids to the correct intracellular compartment. Zein, the principal maize prolamin, has attracted interest as a biodegradable, self-assembling carrier that can protect cargo and be combined with polymeric, lipidic, targeted and biomimetic components. This review critically evaluates zein-based systems for plasmid DNA, siRNA, antisense oligonucleotides and related nucleic-acid cargos. Native zein is best regarded as a protective and sustained-release matrix rather than a stand-alone high-efficiency transfection vector. In contrast, hybrid systems can add nucleic-acid condensation, colloidal stabilization, targeting and intracellular-trafficking functions through components such as chitosan, polyethylenimine, dendritic poly(l-lysine), lipids and targeting ligands. Direct evidence of endosomal escape remains limited, with only one reviewed study providing imaging evidence consistent with improved lysosomal escape. Cargo-specific evidence is strongest for plasmid DNA, with functional proof-of-concept also reported for selected siRNA and antisense oligonucleotide systems, whereas robust mRNA translation and CRISPR genome editing have not yet been demonstrated with zein-based carriers. The translational rationale for zein lies not in superior intrinsic transfection efficiency, but in route-specific protection, sustained release, hydrophobic drug co-loading and use as a biodegradable scaffold within multifunctional hybrids. Zein-based gene delivery remains preclinical and requires stronger mechanistic, cargo-specific and route-specific validation.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"154850"},"PeriodicalIF":8.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alginate-based dual-drug bridging hydrogels harnessing dynamic PtO coordination for programmed drug delivery and efficient cancer combination therapy.","authors":"Shu Wei, Yanglin Lv, An Yan, Jun Yang, Muhan Chen, Zixuan Wang, Xinyi Chen, Mengping Qu, Xiaodan Xie, Hongcheng Sun, Jiayun Xu, Junqiu Liu, Shuangjiang Yu","doi":"10.1016/j.ijbiomac.2026.154870","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.154870","url":null,"abstract":"<p><p>Although hydrogel-based drug delivery shows promise for localized cancer therapy, effective combination strategies remain needed. Herein, a dual-drug bridging hydrogel was engineered using cisplatin (CDDP) and hematoporphyrin (HP) as crosslinking agents to improve combination therapy for tumors. This hydrogel platform facilitates the codelivery of aCTLA-4 antibodies and exhibits potent antitumor efficacy in a melanoma model. PtO coordination bonds among CDDP, HP, and sodium alginate stabilize the scaffold and reduce the burst release of HP, thereby enhancing photodynamic therapy. Under 630 nm laser irradiation, HP produces cytotoxic reactive oxygen species, and the hydrogel matrix breaks down in response to environmental triggers, enabling sustained drug release and resulting in prolonged therapeutic effects. This process induces cell apoptosis and releases tumor antigens and damage-associated molecular patterns. In a subcutaneous B16-F10 melanoma model, aCTLA-4@HP-SC-Gel with laser irradiation achieved exceeding 97% tumor growth inhibition and prolonged 50-day survival, with no obvious systemic toxicity. It increased intratumoral CD8⁺ T cells by 11-fold and promoted M1 macrophage polarization. By integrating chemotherapy, photodynamic therapy, and immunotherapy, this dual-drug bridging hydrogel offers a hopeful strategy for localized treatment of superficial tumors.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"154870"},"PeriodicalIF":8.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct Ca²⁺-binding thermodynamics reveal a paralogue-specific structural response in the calmodulin-like domain of α-actinin-4.","authors":"Jošt Hočevar, Matic Kovačič, Janez Plavec, Kristina Djinović-Carugo, Miha Pavšič","doi":"10.1016/j.ijbiomac.2026.154866","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.154866","url":null,"abstract":"<p><p>The actin cytoskeleton, a complex and dynamic network, is precisely organized into structurally and functionally diverse assemblies by actin-binding proteins. A major group of actin crosslinking proteins are α-actinins. The non-muscle forms, α-actinin-1 and -4, are ubiquitous proteins whose actin crosslinking activity is regulated by Ca²⁺ ions. The molecular mechanism of regulation is unknown, but it has been suggested to be driven by structural changes triggered by the binding of Ca²⁺ ions to their calmodulin-like domain (CaMD). While the structure and Ca²⁺-binding properties of human α-actinin-1 CaMD have already been investigated, no such data were available for the α-actinin-4 CaMD. To address this, we used structurally informed mutagenesis and isothermal titration calorimetry (ITC) to confirm a homologous single Ca²⁺-binding site in the N-terminal lobe of the α-actinin-4 CaMD. In stark contrast to the α-actinin-1 CaMD, where binding is endothermic, binding to the α-actinin-4 CaMD is exothermic and displays a 6-fold lower affinity towards Ca²⁺. These distinct thermodynamic signatures suggest a paralogue-specific conformational change. Indeed, protein NMR spectroscopy revealed a unique Ca²⁺-induced conformational change of the C-terminal lobe, providing new insights into the molecular mechanisms that modulate α-actinin-mediated actin crosslinking.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"154866"},"PeriodicalIF":8.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering acid-sensing ion channel 1a with disrupted desensitization: A computer-guided approach.","authors":"Mahdi Hassankalhori, Mina Hanna, Ferran Sancho, Juan Torras, Stephan Kellenberger, Maria Fátima Lucas","doi":"10.1016/j.ijbiomac.2026.154826","DOIUrl":"10.1016/j.ijbiomac.2026.154826","url":null,"abstract":"<p><p>Human Acid-Sensing Ion Channel 1a (hASIC1a) is a complex, multi-state membrane macromolecule whose rapid desensitization limits its application as a natural biosensor. To manipulate these structural dynamics, we designed and applied an integrative computational approach, combining protein residue network analysis and a machine learning-based functional site model, to identify functionally important positions governing hASIC1a desensitization. Focusing on structural communication regions, we pinpointed novel regulatory positions modulating the channel's conformational dynamics involving the desensitized state. Through the experimental characterization of a targeted library of 26 variants across nine predicted positions, we discovered three critical regulatory functional sites (Y426, L453, and Y456). Mutations at these sites yielded eight variants that successfully impaired or disrupted desensitization over a wide pH range, resulting in sustained current properties. This study demonstrates how our integrative computational strategy can be successfully applied to dynamically intricate membrane proteins, efficiently identifying mutational hotspots to engineer and fine-tune complex macromolecular functional properties.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"154826"},"PeriodicalIF":8.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effect of modified konjac glucomannan and biological enzyme induced carbonate precipitation on the biocementation of soil fugitive dust.","authors":"Xiaonan Wang, Kai Chen, Peng Chen, Chongyu Zhang, Yue Hu, Guihong Liu, Yong Zhang, Yongjie Shi, Chenyu Kong, Xiang Li","doi":"10.1016/j.ijbiomac.2026.154834","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.154834","url":null,"abstract":"<p><p>Soil fugitive dust poses a serious threat to human health, the plant-derived polysaccharide konjac glucomannan was modified to obtain konjac glucomannan-acrylic acid graft copolymer (KGMP), which was combined with enzyme induced carbonate precipitation (EICP) to control it. The performance of KGMP-EICP was evaluated. Microstructure characterization was performed on the treated soil fugitive dust samples, and molecular dynamics simulations were employed to investigate how KGMP regulates the nucleation of calcium carbonate, thereby elucidating the fugitive dust control principle of KGMP-EICP. Results indicate that the concentration of KGMP at 3 mg/mL maximizes the yield of calcium carbonate in EICP. KGMP improves the EICP's resistance to wind erosion, the hardness of the solidified layer, water retention, and resistance to rain erosion, while exhibiting a moderate degradation rate. In field experiments, KGMP-EICP exhibited a lower average daily TSP concentration than EICP after 30 days. Microscopic characterization revealed that KGMP resulted in a more uniform calcium distribution, regulated the preferential orientation of calcite crystals, and increased their crystallinity and grain size. In the molecular dynamics simulation, KGMP provided sites for the precipitation of calcium carbonate, which improved the probability of the combination of carbonate ions and calcium ions, and increased the average interaction energy between them by 521.27 Kcal/mol. The dust suppression mechanism of KGMP-EICP is that the soil fugitive dust forms a dense solidified layer of calcite under the regulation of KGMP. This study provides theoretical support and new strategies for the application of biomacromolecular functional materials in dust pollution control.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"154834"},"PeriodicalIF":8.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting cellulosic fibrils in papermaking: from ancient papermaking principles to room-temperature engineering of \"plastic-like\" paper via in-situ fibril-derived additives.","authors":"Jianmin Peng, Xin Fu, Gavin Scott, Rob Barker, Graham Ormondroyd, Simon F Curling, Hui Mao, Jing Shen","doi":"10.1016/j.ijbiomac.2026.154859","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.154859","url":null,"abstract":"<p><p>Papermaking, one of ancient China's greatest innovations, shaped human civilization through the creation of true paper, widely attributed to Cai Lun during the Eastern Han Dynasty. A defining feature of this invention was the formation of fibrillated microstructures during fibre processing, which promoted fibre bonding and sheet formation. Inspired by this principle, the present work revisits the structural role of cellulosic fibrils and explores their potential as functional building blocks for materials innovation. By enhancing fibrillation through controlled pulp refining, a straightforward room-temperature strategy was developed to produce \"plastic-like\" paper, herein referring to cellulosic paper combining high wet strength, flexibility, and liquid barrier performance while retaining its fibrous structure. During treatment with a non-derivatizing zinc chloride-based solvent system, accessible fibrillated structures are proposed to undergo partial dissolution and subsequently regenerate within the fibre network, forming in-situ fibril-derived additives. The resulting fibril-derived material acts as an in-situ binding phase within the paper structure, bridging adjacent fibres and filling interfibre voids, thereby consolidating the network while preserving the overall fibrous architecture. As a result, the treated paper exhibits plastic-like high wet strength, improved liquid barrier performance, and antibacterial activity associated with residual zinc species. Because fibrillated microstructures are widely present in refined pulps, the approach also shows potential for application to different papermaking fibres. Rooted in the principles of papermaking wet-end chemistry and chemical additives, this work reinterprets cellulosic fibrils as in-situ functional additives and highlights new opportunities for designing multifunctional sustainable materials.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"154859"},"PeriodicalIF":8.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicochemical properties, in vitro digestive behavior, and fecal fermentation characteristics of a polysaccharide fraction from Triadica rotundifolia.","authors":"Peiyao Wang, Siming Zhu, Xinyu Wang, Yulan Gan, Haiyan Zhao","doi":"10.1016/j.ijbiomac.2026.154852","DOIUrl":"10.1016/j.ijbiomac.2026.154852","url":null,"abstract":"<p><p>In this study, a polysaccharide fraction from Triadica rotundifolia (formerly Sapium rotundifolium Hemsl.), designated RSP, was obtained by hot-water extraction, ethanol precipitation, Sevag deproteinization, and sequential chromatographic purification. Its physicochemical characteristics, simulated digestive behavior, and effects on human fecal microbiota were systematically evaluated. RSP was obtained at a yield of 1.21%, and high-performance gel permeation chromatography (HPGPC) showed a dominant chromatographic peak with a weight-average molecular weight (Mw) of 322,357 Da. RSP exhibited a distinct monosaccharide composition, with arabinose, glucuronic acid, galactose, and glucose as the major monosaccharides. Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and atomic force microscopy (AFM) further revealed typical polysaccharide functional groups and an aggregated, irregular morphological organization. During simulated gastrointestinal digestion, reducing-sugar equivalents changed only slightly during the salivary and gastric phases but increased markedly during the intestinal phase. The presence of RSP during in vitro fecal fermentation resulted in notable alterations in culture turbidity, progressive acidification, relative SCFA profiles, and microbial community structure. Furthermore, 16S ribosomal RNA gene sequencing revealed distinct fecal microbial community profiles among the RSP, Blank, and INU groups. In the LEfSe multigroup comparison, Bifidobacterium was identified as one of the taxa characterizing the RSP group. Collectively, these findings provide an integrated characterization of the physicochemical properties, in vitro digestive behavior, and fecal fermentation characteristics of RSP.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"154852"},"PeriodicalIF":8.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of the multi-scale structure of starch-based materials in determining the compaction behavior of pharmaceutical powders.","authors":"Yuan Lin, Xiao Lin, Lan Shen, Lijie Zhao","doi":"10.1016/j.ijbiomac.2026.154858","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.154858","url":null,"abstract":"<p><p>This study aimed to investigate the multiscale structural evolution of starch under mechanical stress and its impact on the mechanical behavior of tablets. The study systematically characterized the multiscale structure, compression behavior, and tablet quality of seven types of starches with different initial structures (native starch, partially hydrolyzed starch, and deeply hydrolyzed starch) before and after dry granulation. The results demonstrate that dry granulation results in a reduction in the short-range and long-range ordered structures of starch (crystallinity decreased by 25.58-61.60%). This stress-induced structural disorder is correlated with increased plastic deformation in native starch and the fragmentation of hydrolyzed starch particles. The enhanced tensile strength (145.95%-228.57%) of partially hydrolyzed starch tablets may result from the increased specific surface area generated by particle fragmentation. In contrast, amorphous maltodextrin after granulation exhibits an enhanced elastic response due to mechanical densification and work hardening, with loss of tabletability. The correlation analysis indicates that the tensile strength of tablets is positively correlated with plastic deformation parameters and roughness, while it is negatively correlated with elastic parameters, short-range order, and crystallinity. These results indicate that the effect of dry granulation on tablet quality depends on the initial structural characteristics. While granulation improves the performance of starch-based tablets with high elastic response by disrupting their ordered structure, it may impair the performance of starch-based tablets with strong plastic deformation capacity due to work hardening. This structure-dependent regulatory relationship provides a theoretical basis for the design of starch-based excipients in solid dosage forms.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"154858"},"PeriodicalIF":8.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}