International Journal of Biological Macromolecules最新文献_第6页

Novel pH-responsive folate conjugated chitosan and thiolated carboxymethyl cellulose based nanoparticles: potential approach for site-specific targeting in colon cancer treatment 新的ph响应叶酸共轭壳聚糖和巯基羧甲基纤维素纳米颗粒：结肠癌治疗中特异性靶向的潜在方法

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-05-05 DOI: 10.1016/j.ijbiomac.2025.143952

Hanasul Hanan , Fahad Pervaiz , Muhammad Ijaz , Tahreem Arshad , Komal Saeed , Syeda Munazza Javaid , Pakeeza Hussain , Asma Majeed

{"title":"Novel pH-responsive folate conjugated chitosan and thiolated carboxymethyl cellulose based nanoparticles: potential approach for site-specific targeting in colon cancer treatment","authors":"Hanasul Hanan , Fahad Pervaiz , Muhammad Ijaz , Tahreem Arshad , Komal Saeed , Syeda Munazza Javaid , Pakeeza Hussain , Asma Majeed","doi":"10.1016/j.ijbiomac.2025.143952","DOIUrl":"10.1016/j.ijbiomac.2025.143952","url":null,"abstract":"<div><div>The study objective was to develop folate decorated chitosan (CHT-FA) by the carbodiimide-mediated process to utilize the overexpressed folate receptors in the treatment of colon cancer. The substitution degree of FA to CHT was 1.4 %. FTIR and H<sup>1</sup>NMR ensured the successful conjugation of FA with CHT. Thermal analysis and XRD demonstrated the thermal stability and amorphous nature of CHT-FA after conjugation. Thiolation of carboxymethyl cellulose, having a 1612.35 μmol/g thiol group, was achieved via oxidation followed by reductive amination. CHT-FA and thiolated carboxymethyl cellulose (CMC-SH) were utilized in the development of nanoparticles with eudragit S100 coating (EU-FU-CHT-FA/CMC-SH NPs) for targeted delivery to the colon. The fabricated NPs demonstrated a higher release pattern at 7.4 pH after <5 % release at 1.2 pH. CHT-FA/CMC-SH NPs showed enhanced mucoadhesion time by up to 237 min. Furthermore, compared to the FU solution, the MTT analysis showed that FU-CHT-FA/CMC-SH NPs had a more cytotoxic effect and increased cellular uptake in the Caco-2 cell line via the folate receptor-facilitated endocytosis process along with the consequence of thiolation which prevents closer of tight junction, resulting in enhanced cellular absorption. These findings support the potential of the developed NPs as a tumor-targeted therapeutic delivery.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"311 ","pages":"Article 143952"},"PeriodicalIF":7.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ATAD2 bromodomain in cancer therapy: current status and future perspectives ATAD2溴结构域在癌症治疗中的现状及未来展望

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-05-05 DOI: 10.1016/j.ijbiomac.2025.143948

Tincy Biju , Chidananda Venkatesh , Darshana Ballagere Honnasiddappa , Mallikarjun Sajjan , Nayan Kumar Mahadeva , Basavana Gowda Hosur Dinesh , Bandral Sunil Kumar , Srinivas Ganjipete , Mohankumar Ramar , Selvaraj Kunjiappan , Panneerselvam Theivendren , Sundar Madasamy , Kumarappan Chidambaram , Damodar Nayak Ammunje , Parasuraman Pavadai

{"title":"ATAD2 bromodomain in cancer therapy: current status and future perspectives","authors":"Tincy Biju , Chidananda Venkatesh , Darshana Ballagere Honnasiddappa , Mallikarjun Sajjan , Nayan Kumar Mahadeva , Basavana Gowda Hosur Dinesh , Bandral Sunil Kumar , Srinivas Ganjipete , Mohankumar Ramar , Selvaraj Kunjiappan , Panneerselvam Theivendren , Sundar Madasamy , Kumarappan Chidambaram , Damodar Nayak Ammunje , Parasuraman Pavadai","doi":"10.1016/j.ijbiomac.2025.143948","DOIUrl":"10.1016/j.ijbiomac.2025.143948","url":null,"abstract":"<div><div>ATPase family AAA domain-containing protein 2, or ATAD2, is a novel carcinogen, essential for cancer development, chromatin remodeling, and transcriptional control. It contains a bromodomain, which binds to acetylated histones to control gene expression. It also impacts pathways that regulate the cell cycle, DNA replication, and hormone signalling. ATAD2 is overexpressed in several malignancies, including colorectal, lung, ovarian, and breast cancers, and cancer metastasis. Investigations into the function of ATAD2 in oncogenesis and its interactions may offer fresh approaches to creating cancer treatment plans. Although preclinical research is very encouraging, many unresolved aspects regarding therapeutic development remain, including toxicity being explored concurrently. Investigations into the function of ATAD2 in oncogenesis may offer fresh approaches to developing chemotherapy strategies. Most of ATAD2's molecular mechanisms behind carcinogenesis and functions are discussed here. Additionally, we included progress, including potential monoclonal antibodies, RNA-based therapies, and small chemical inhibitors, in the review. Therefore, we guarantee this study will provide researchers with new opportunities and directions for cancer therapeutics.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"311 ","pages":"Article 143948"},"PeriodicalIF":7.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Jerivá (Syagrus romanzoffiana) fruit fibers valorization as cellulose and lignocellulose nanofibers source for nanopaper production 樱桃果纤维作为纤维素和木质纤维素纳米纤维的来源，用于纳米纸的生产

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-05-05 DOI: 10.1016/j.ijbiomac.2025.143905

Juliana Farinassi Mendes , Maycon Jhony Silva , Natália Cristina Evangelista , Lóren de Paula Lopes , Maria Alice Martins , Rafael Farinassi Mendes , Luiz Henrique Capparelli Mattoso

{"title":"Jerivá (Syagrus romanzoffiana) fruit fibers valorization as cellulose and lignocellulose nanofibers source for nanopaper production","authors":"Juliana Farinassi Mendes , Maycon Jhony Silva , Natália Cristina Evangelista , Lóren de Paula Lopes , Maria Alice Martins , Rafael Farinassi Mendes , Luiz Henrique Capparelli Mattoso","doi":"10.1016/j.ijbiomac.2025.143905","DOIUrl":"10.1016/j.ijbiomac.2025.143905","url":null,"abstract":"<div><div>This study highlights the innovative use of Jerivá (<em>Syagrus romanzoffiana</em>) fruit pulp fibers— a poorly explored lignocellulosic source —as a sustainable and promising alternative to conventional raw materials for nanocellulose production. Nanofibrillated lignocellulose (LCNF) and nanofibrillated cellulose (CNF) were successfully extracted through alkaline treatment followed by mechanical defibrillation and subsequently applied to fabricate nanopapers (LCNP and CNP) via the casting method. The resulting suspensions were evaluated for stability and microstructure. In addition, the optical, physico-mechanical, and barrier properties of LCNP and CNP were investigated. The LCNF and CNF suspensions showed good stability of suspended particles. Notably, CNPs showed significant improvements in transparency (98 % at 600 nm), tensile strength (TS, 55.3 MPa), and elastic modulus (EM, 64.1 MPa) compared to LCNPs. Although the LCNP exhibited TS of nearly 30 MPa, improvements were observed in the contact angle and a reduction in water vapor permeability (WVP) of around 86 % and 5 %, respectively, compared to the CNP. Therefore, Jerivá fruit stands out as a promising, accessible, and innovative source for obtaining LCNF and CNF, with both raw materials showing great potential for applications in packaging companies and as composite reinforcement.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"311 ","pages":"Article 143905"},"PeriodicalIF":7.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro assessment of the effect of Porphyra haitanensis polysaccharides on the intestinal flora of allergic mice 海棠紫菜多糖对过敏性小鼠肠道菌群影响的体外研究

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-05-05 DOI: 10.1016/j.ijbiomac.2025.143950

Peilin Chen , YuShan Huang , Hongliang Zeng , Mingjing Zheng , Juanjuan Guo

{"title":"In vitro assessment of the effect of Porphyra haitanensis polysaccharides on the intestinal flora of allergic mice","authors":"Peilin Chen , YuShan Huang , Hongliang Zeng , Mingjing Zheng , Juanjuan Guo","doi":"10.1016/j.ijbiomac.2025.143950","DOIUrl":"10.1016/j.ijbiomac.2025.143950","url":null,"abstract":"<div><div>This study systematically investigated the modulatory effects of <em>Porphyra haitanensis</em> polysaccharides (PHP) and its two <em>P. haitanensis</em> polysaccharide components (PHP40 and PHP80) on gut microbiota in ovalbumin (OVA)-sensitized mice <em>via in vitro</em> fermentation. PHP40 and PHP80 exhibited sulfate contents of 5.94 ± 0.05 % and 11.72 ± 0.03 %, respectively, with galactose and glucose as dominant monosaccharides. The different polysaccharide components had different effects on the aforementioned changes in the species composition and structure of the gut microbiota in allergic mice, with distinct dominant microbial profiles across groups. PHP could promote <em>Bacillus</em> and <em>Enterococcus</em> proliferation while inhibiting <em>Staphylococcus</em>. PHP40 and PHP80 could promote <em>Enterococcus</em> and <em>Enterobacter</em> growth but suppressed <em>Staphylococcus</em> and <em>Bacillus</em>. Functional prediction indicated PHP significantly improved galactose metabolism and primary/secondary bile acid biosynthesis, potentially alleviating allergic responses.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"311 ","pages":"Article 143950"},"PeriodicalIF":7.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Water-based green media for the synthesis of cellulose acid half-esters: physicochemical characterization and conformation-modulating interactions 合成纤维素酸半酯的水基绿色介质：物理化学表征和构象调节相互作用

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-05-05 DOI: 10.1016/j.ijbiomac.2025.143968

Nafea Achalhi , Youssef El Ouardi , Ridouan El Yousfi , Ayoub Abarkan , Soufian El Barkany , Abderrahman El Idrissi

{"title":"Water-based green media for the synthesis of cellulose acid half-esters: physicochemical characterization and conformation-modulating interactions","authors":"Nafea Achalhi , Youssef El Ouardi , Ridouan El Yousfi , Ayoub Abarkan , Soufian El Barkany , Abderrahman El Idrissi","doi":"10.1016/j.ijbiomac.2025.143968","DOIUrl":"10.1016/j.ijbiomac.2025.143968","url":null,"abstract":"<div><div>This study presents a simple and ecofriendly pathway for synthesizing of cellulose acid half-esters, utilizing a toxic organic solvent-free synthesis strategy and ensuring a green approach. The esterification of hydroxyethyl cellulose (HEC), derived from <em>Stipa tenacissima</em>, with maleic, succinic, and phthalic anhydrides was investigated, revealing significant structural and physicochemical modifications. Increasing the anhydride/HEC molar ratio enhanced the degree of substitution (DS), reaching values of 1.4, 1.28, and 0.51 for HEC-AS, HEC-AM, and HEC-AP, respectively. High reaction temperatures (>100 °C) promoted cross-linking, affecting the solubility of the modified polymers. Structural analysis showed that the organization of acid half-esters strongly influenced wetting properties and thermal behavior. HEC-AM and HEC-AP exhibited lower <em>T</em><sub><em>g</em></sub> values (40 °C and 91.82 °C) due to hydrogen bonding reorganization and the resulted configuration of the acid half-ester groups, while HEC-AS remained stable at 117.76 °C. These structural differences resulted in distinct contact angles of 55°, 90°, and 102°, respectively. Solubility and surface charge studies further confirmed the impact of modification on polymer charge behavior, resulting in an anionic character. These findings demonstrate the effectiveness of this green synthesis strategy in tailoring biopolymer properties for functional applications.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"311 ","pages":"Article 143968"},"PeriodicalIF":7.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PtrCWINV3 encoding a cell wall invertase regulates carbon flow to wood in Populus trichocarpa 编码细胞壁转化酶的PtrCWINV3调控毛杨向木材的碳流

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-05-05 DOI: 10.1016/j.ijbiomac.2025.143891

Shuang Zhang , Yuanzhi Yang , Ruhui Chang , Shiqi Yao , Fengbo Xue , Zhaoyin Hou , Guanjun Liu , Zhiru Xu

{"title":"PtrCWINV3 encoding a cell wall invertase regulates carbon flow to wood in Populus trichocarpa","authors":"Shuang Zhang , Yuanzhi Yang , Ruhui Chang , Shiqi Yao , Fengbo Xue , Zhaoyin Hou , Guanjun Liu , Zhiru Xu","doi":"10.1016/j.ijbiomac.2025.143891","DOIUrl":"10.1016/j.ijbiomac.2025.143891","url":null,"abstract":"<div><div>Cell wall invertase (CWINV) catalyzes the hydrolysis of sucrose into glucose and fructose in the apoplastic unloading pathway, with carbon sources provided for sink tissues. However, its role in wood formation remains undetermined. Therefore, transgenic lines overexpressing <em>PtrCWINV3</em> or with knocked-out <em>PtrCWINV3</em> expression were generated in <em>Populus trichocarpa</em>. Compared with wild type, the <em>PtrCWINV3</em>-knockout lines showed decreased CWINV activity (by 7.4 %–10.8 %), which resulted in a 1.5 %–1.8 % decrease in cellulose content, a 0.82 %–0.98 % decrease in hemicellulose content, and an increase in lignin content (by 2.9 %–4.7 %). These changes in structural carbohydrate contents were accompanied with anomalies in the late stages of secondary xylem development, characterized by reduced width of the secondary xylem, fewer cell layers in secondary xylem, and thinner fiber cell walls. The lines overexpressing <em>PtrCWINV3</em> under the control of the DX15 promoter in the developing xylem showed the opposite phenotype. Transcriptome data from the developing xylem indicated that <em>PtrCWINV3</em> regulated the expression of genes involved in the biosynthesis of cellulose (<em>CesA</em>, <em>EG</em>, and <em>CB</em>), hemicellulose/pectin (<em>UGD</em>, <em>AXS</em>, <em>GATL</em>, <em>UAM</em>, <em>PAE</em>, and <em>GAUT</em>), and starch (<em>GBSS</em>), which suggested its involvement in multiple polysaccharide metabolic pathways. Ultimately, this facilitated the synthesis of structural carbohydrate components such as cellulose and hemicellulose, which promoted the later stages of secondary xylem development. These findings not only demonstrate the significant role of CWINV activity in wood formation, but also highlight an excellent candidate gene for breeding new poplar varieties with high cellulose and low lignin contents.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"311 ","pages":"Article 143891"},"PeriodicalIF":7.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanogel-dressed Candida rugosa lipase: Enhanced biocatalysis through hierarchically porous metal organic frameworks' integration 纳米凝胶修饰的念珠菌脂肪酶：通过分层多孔金属有机框架的整合增强生物催化

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-05-05 DOI: 10.1016/j.ijbiomac.2025.143964

Prasanna J. Patil , Xin Liang , Nagesh Manurkar , Ali Akhtiar , Haroon Shah , Chengnan Zhang , Weiwei Li , Xiuting Li

{"title":"Nanogel-dressed Candida rugosa lipase: Enhanced biocatalysis through hierarchically porous metal organic frameworks' integration","authors":"Prasanna J. Patil , Xin Liang , Nagesh Manurkar , Ali Akhtiar , Haroon Shah , Chengnan Zhang , Weiwei Li , Xiuting Li","doi":"10.1016/j.ijbiomac.2025.143964","DOIUrl":"10.1016/j.ijbiomac.2025.143964","url":null,"abstract":"<div><div><em>Candida rugosa</em> lipase (CRL) is a multifunctional biological macromolecule extensively employed in biocatalysis, but its stability and reusability remain significant challenges. This study investigates the immobilization of CRL nanogels onto hierarchically porous metal-organic frameworks (HP-MOFs), possessing adjustable porosity, high surface area, and stability, making them ideal for enzyme immobilization. CRL nanogels were synthesized and immobilized onto three different HP-MOFs: hZIF-8, HP-UiO-66-NH₂, and HP-CuBTC via adsorption. The HP-MOFs were synthesized using soft templating, post-synthetic ligand substitution, and rapid room-temperature templating, ensuring high porosity and structural integrity. The CRL nanogels, characterized by transmission electron microscopy (TEM), fluorescence spectroscopy, and fourier transform infrared spectroscopy (FTIR), were encapsulated in polyacrylamide nanogels, suggesting a hydrophobic environment within the matrix. Comprehensive characterization using scanning electron microscopy (SEM), TEM, thermogravimetric analysis (TGA), FTIR, X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) surface area analysis, and X-ray photoelectron spectroscopy (XPS) confirmed successful immobilization while preserving structural integrity. Enzyme kinetics analysis revealed that the nanoCRL@HP-MOF composites exhibited significantly enhanced enzymatic activity, stability, and reusability compared to free CRL. To the best of our knowledge, this study represents the first demonstration of CRL nanogel immobilization on multiple HP-MOFs, providing valuable insights into their potential as enzyme carriers with promising applications in biotechnological processes.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"311 ","pages":"Article 143964"},"PeriodicalIF":7.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and characterization of κ-carrageenan/yam starch composite films incorporated with cinnamaldehyde Pickering emulsions 肉桂醛皮克林乳剂复合κ-卡拉胶/山药淀粉膜的制备与表征

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-05-05 DOI: 10.1016/j.ijbiomac.2025.143947

Jinhang Lu, Xiumei Xi, Yifan Wang, Kaiyue Wang, Shasha Zhang, Xue Zhou, Xiangyou Wang, Xin Han, Juan Wang

{"title":"Preparation and characterization of κ-carrageenan/yam starch composite films incorporated with cinnamaldehyde Pickering emulsions","authors":"Jinhang Lu, Xiumei Xi, Yifan Wang, Kaiyue Wang, Shasha Zhang, Xue Zhou, Xiangyou Wang, Xin Han, Juan Wang","doi":"10.1016/j.ijbiomac.2025.143947","DOIUrl":"10.1016/j.ijbiomac.2025.143947","url":null,"abstract":"<div><div>Plastic packaging is highly resistant to degradation, leading to significant environmental pollution. Therefore, it is necessary to develop a new type of packaging material, especially natural polymer-based packaging materials. This study aimed to prepare a κ-carrageenan/yam starch (KC/YS) composite film incorporating cinnamaldehyde-based Pickering emulsions (CA-PE) to resolve the aforementioned issue and to investigate the impact of the CA-PE on the physicochemical characteristics and bioactivity of the composite films. The scanning electron microscopy image analysis revealed that the CA Pickering emulsion with a 15 % volume fraction (CA-PE-15 %) was homogeneously dispersed within the composite films. The thermogravimetric analysis revealed enhanced thermal stability of the composite films after CA-PE addition. The water contact angle measurements demonstrated a significant improvement (<em>P</em> < 0.05) in hydrophobicity. The composite films exhibited superior barrier properties in the ultraviolet spectrum and significantly enhanced antioxidant capacity (<em>P</em> < 0.05) following the incorporation of the CA-PE emulsion. Moreover, the composite film containing CA-PE-15 % exhibited potent inhibitory effects against <em>Escherichia coli</em> and <em>Staphylococcus aureus</em>, demonstrating excellent antibacterial activity. In summary, the KC/YS composite films incorporating cinnamaldehyde-based PE exhibited superior properties and displayed immense potential for diverse applications.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"311 ","pages":"Article 143947"},"PeriodicalIF":7.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of the hydrophobic polyhydroxyethyl methacrylate branches grafted with high amylose corn starch on the properties of its electrospun drug-loaded membranes 高直链玉米淀粉接枝疏水聚甲基丙烯酸羟乙酯枝对电纺丝载药膜性能的影响

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-05-05 DOI: 10.1016/j.ijbiomac.2025.143962

Xun Zhang , Yujie Wu , Yingfeng Wang , Maoli Yin , Zhenzhen Xu , Feng Liu , Wei Li

{"title":"Influence of the hydrophobic polyhydroxyethyl methacrylate branches grafted with high amylose corn starch on the properties of its electrospun drug-loaded membranes","authors":"Xun Zhang , Yujie Wu , Yingfeng Wang , Maoli Yin , Zhenzhen Xu , Feng Liu , Wei Li","doi":"10.1016/j.ijbiomac.2025.143962","DOIUrl":"10.1016/j.ijbiomac.2025.143962","url":null,"abstract":"<div><div>The nanofiber membranes based on native starch are prone to swelling or dissolution after contact with water, and the fragile starch membranes, due to the aging of molecular chains, are unsuitable for medical dressings. Herein, the hydrophobic polyhydroxyethyl methacrylate (PHEMA) branches in different ratios were grafted onto high amylose corn starch (HACS) using a redox system. Furthermore, electrospun aspirin-loaded nanofiber membranes were prepared and investigated in terms of porosity, swelling capacity, water vapor transmittance rate (WVTR), cumulative release rate, and cytotoxicity. The results confirmed that with increasing grafting ratio, the porosity and WVTR of the HACS<em>-g-</em>PHEMA drug-loaded membrane gradually increased, while swelling capacity slightly decreased from 746.2% to 619.9%, and the cumulative release rate decreased from 56.21% to 32.54% in 2 h. The Ritger-Peppas mathematical model fitting found that the diffusion coefficients of drug-loaded membranes were less than 0.45, which belonged to the Fick diffusion behavior. After the grafting of PHEMA branches, the hydrophobic interaction between starch molecular chains and aspirin was enhanced, and the nanofiber membrane defects were alleviated while still maintaining good biocompatibility. This study provides a foundation for the sustained release of hydrophobic drugs in starch-based medical dressings.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"311 ","pages":"Article 143962"},"PeriodicalIF":7.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and performance of regenerated cellulose/polylactic acid non-leaching antibacterial composite membrane 再生纤维素/聚乳酸非浸出抗菌复合膜的制备及性能研究

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-05-05 DOI: 10.1016/j.ijbiomac.2025.143960

Hongbo Wang , Jinhong Xue , Junming Liang , Xianpei Xu , Limin You , Yaxin An , Fu Li , Pengfei Fei , Shuqiang Liu , Mei Liu , Fulai Zhao

{"title":"Preparation and performance of regenerated cellulose/polylactic acid non-leaching antibacterial composite membrane","authors":"Hongbo Wang , Jinhong Xue , Junming Liang , Xianpei Xu , Limin You , Yaxin An , Fu Li , Pengfei Fei , Shuqiang Liu , Mei Liu , Fulai Zhao","doi":"10.1016/j.ijbiomac.2025.143960","DOIUrl":"10.1016/j.ijbiomac.2025.143960","url":null,"abstract":"<div><div>Composite membranes with excellent antibacterial properties, hydrophilic/hydrophobic differentiation, and selective permeability are preferred materials for wound dressings. In this work, antibacterial bromoacetyl and quaternary ammonium groups were chemically introduced into a regenerated cellulose nanofiber membrane. This hydrophilic membrane was then compounded with a polylactic acid (PLA) liquid film through a non-solvent-induced phase separation process to prepare a composite membrane. FTIR, XPS, and EDS results confirmed the successful chemical modification and presence of antibacterial groups. SEM analysis revealed a stable composite with an asymmetric structure. Modification time, particularly the bromoacetylation duration, had a certain impact on the structure and properties of the composite membrane. The optimized composite membrane exhibited excellent gas permeability (air and water vapor) and differentiated hydrophilic/hydrophobic properties. Membrane modified via bromoacetylation for over 3 h demonstrated >95 % antibacterial efficiency against <em>Escherichia coli</em> and <em>Staphylococcus aureus</em>, indicating broad-spectrum efficacy. The biomass-derived polymer matrix, scalable production process, and multifunctionality highlight its potential for healthcare applications, particularly in wound dressings.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"311 ","pages":"Article 143960"},"PeriodicalIF":7.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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