International Journal of Biological Macromolecules最新文献

筛选
英文 中文
High thermal conductive and photothermal phase change material microcapsules via cellulose nanocrystal stabilized Pickering emulsion for solar harvesting and thermal energy storage.
IF 7.7 1区 化学
International Journal of Biological Macromolecules Pub Date : 2025-01-01 Epub Date: 2024-11-28 DOI: 10.1016/j.ijbiomac.2024.138162
Qiang Wei, Wang Sun, Zhe Zhang, Guofu Zhou, Zhen Zhang
{"title":"High thermal conductive and photothermal phase change material microcapsules via cellulose nanocrystal stabilized Pickering emulsion for solar harvesting and thermal energy storage.","authors":"Qiang Wei, Wang Sun, Zhe Zhang, Guofu Zhou, Zhen Zhang","doi":"10.1016/j.ijbiomac.2024.138162","DOIUrl":"10.1016/j.ijbiomac.2024.138162","url":null,"abstract":"<p><p>Phase change materials (PCMs) are promising for thermal energy storage due to their high latent enthalpy and constant phase change temperature. However, organic PCMs suffer from leaking, low thermal conductivity, and flammability. Herein, high thermal conductivity, photothermal and flame-proof docosane microcapsules with melamine-formaldehyde (MF) and polypyrrole (PPy) (C<sub>22</sub>-CMFP) were reported with cellulose nanocrystal (CNC) stabilized Pickering emulsion droplets as templates through in-situ polymerization. CNCs showed outstanding C<sub>22</sub> Pickering emulsifying ability with the presence of NaCl and provided ideal templates for C<sub>22</sub> microcapsules. The obtained C<sub>22</sub>-CMFP microcapsules displayed high enthalpy (205.7 J/g), C<sub>22</sub> core ratio (86.1 %), and stability. The C<sub>22</sub>-CMFP microcapsules retained an outstanding enthalpy remaining ratio (98.9 %) after 100 times cooling/heating cycles and could tolerate 100 °C for 12 h without leaking due to the robust hybrid CMFP shell. PPy significantly improved the thermal conductivity and photothermal conversion efficiency of C<sub>22</sub>-CMFP microcapsules. The C<sub>22</sub>-CMFP microcapsules exhibited a high thermal conductivity of 0.683 W/(m·K). The maximum temperature of C<sub>22</sub>-CMFP microcapsules under light irradiation for 18 min was 60.4 °C. Moreover, C<sub>22</sub>-CMFP microcapsules showed superb flame-proof properties. This study provides a facile approach to fabricate high enthalpy, stable, thermal conductive, photothermal, and flame-proof PCM microcapsules for solar harvesting and thermal energy storage.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"284 Pt 1","pages":"138162"},"PeriodicalIF":7.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protocatechuic acid/sodium alginate multilayer coating induced by metal ion enhanced the ulcerative colitis alleviations of Lactiplantibacillus plantarum.
IF 7.7 1区 化学
International Journal of Biological Macromolecules Pub Date : 2025-01-01 Epub Date: 2024-11-26 DOI: 10.1016/j.ijbiomac.2024.138122
Yanming Ren, Shuifang Mao, Pin Chen, Wen Tan, Xingqian Ye, Jinhu Tian
{"title":"Protocatechuic acid/sodium alginate multilayer coating induced by metal ion enhanced the ulcerative colitis alleviations of Lactiplantibacillus plantarum.","authors":"Yanming Ren, Shuifang Mao, Pin Chen, Wen Tan, Xingqian Ye, Jinhu Tian","doi":"10.1016/j.ijbiomac.2024.138122","DOIUrl":"10.1016/j.ijbiomac.2024.138122","url":null,"abstract":"<p><p>Oral intake of probiotics is a promising approach to alleviate colitis. However, environmental sensitivity of the gastrointestinal tract and poor adhesion of probiotics to the intestine hamper the remedial effects. In this study, a simple yet effective novel probiotic multilayer coating consisting of Fe<sup>3+</sup>-protocatechuic acid (PCA) crosslinked network and Ca<sup>2+</sup>-induced sodium alginate (SA) for arming Lactiplantibacillus plantarum (LP) was developed. In the dextran sulfate sodium-induced colitis mouse model, SA-PCA-LP effectively alleviated colitis by regulating the expression of inflammatory cytokines, and repairing gut barriers. In addition, SA-PCA-LP regulated the gut microbiota and promoted the production of short-chain fatty acids, which further promoted the remission of colitis. Untargeted metabolomics also revealed that the scymnol, adenosine 5'-monophosphat, guanidylic acid, and 9H-purine-9-ol were significantly up-regulated in SA-PCA-LP group. In general, the novel coating strategies developed in the present study will motivate researchers to arm probiotics with various prebiotics to effectively alleviate colitis.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138122"},"PeriodicalIF":7.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highly efficient production of lacto-N-tetraose in plasmid-free Escherichia coli through chromosomal integration of multicopy key glycosyltransferase genes. 通过染色体整合多拷贝关键糖基转移酶基因,在无质粒大肠杆菌中高效生产乳N-四糖。
IF 7.7 1区 化学
International Journal of Biological Macromolecules Pub Date : 2025-01-01 Epub Date: 2024-11-23 DOI: 10.1016/j.ijbiomac.2024.137987
Qianyi Qian, Longhao Yang, Chunhua Zhao, Mengting Tao, Wenli Zhang, Yingying Zhu, Wanmeng Mu
{"title":"Highly efficient production of lacto-N-tetraose in plasmid-free Escherichia coli through chromosomal integration of multicopy key glycosyltransferase genes.","authors":"Qianyi Qian, Longhao Yang, Chunhua Zhao, Mengting Tao, Wenli Zhang, Yingying Zhu, Wanmeng Mu","doi":"10.1016/j.ijbiomac.2024.137987","DOIUrl":"10.1016/j.ijbiomac.2024.137987","url":null,"abstract":"<p><p>Lacto-N-tetraose (LNT) is a functional human milk oligosaccharide (HMO) commercially added to infant formula. Metabolically engineered strains for efficient production of LNT have been widely constructed. However, most of them rely on the use of plasmids, which might bring metabolic burden and the antibiotic issue. In this study, we attempted to construct a plasmid-free Escherichia coli MG1655 for LNT biosynthesis. Firstly, lacZ gene was disrupted and lacY expression was enhanced to improve the bioavailability of lactose as the initial substrate. Three copies of lgtA (encoding for β1,3-N-acetylglucosaminyltransferase) were integrated into the chromosome, enabling the highly efficient production of lacto-N-triose II (LNTri II) as the direct precursor of LNT. Efficient production of LNT was then optimized by multicopy integration of wbgO (encoding for β1,3-galactosyltransferase), disruption of the competitive pathways, and strengthening of UDP-galactose supply and oligosaccharide efflux. The final titer reached 6.99 and 42.38 g/L in shake-flask and fed-batch cultivation, respectively.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"137987"},"PeriodicalIF":7.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fabrication of biodegradable polyvinyl alcohol-based plastics toward technical lignin valorization.
IF 7.7 1区 化学
International Journal of Biological Macromolecules Pub Date : 2025-01-01 Epub Date: 2024-11-26 DOI: 10.1016/j.ijbiomac.2024.138123
Shuang-Lin Zou, Ling-Ping Xiao, Wen-Zheng Yin, Tao Gui, Run-Cang Sun
{"title":"Fabrication of biodegradable polyvinyl alcohol-based plastics toward technical lignin valorization.","authors":"Shuang-Lin Zou, Ling-Ping Xiao, Wen-Zheng Yin, Tao Gui, Run-Cang Sun","doi":"10.1016/j.ijbiomac.2024.138123","DOIUrl":"10.1016/j.ijbiomac.2024.138123","url":null,"abstract":"<p><p>The fabrication of composite materials from lignin has attracted increasing attention to reducing the dependence of petrochemical-based resources on carbon neutrality. However, the low content of lignin in the biocomposites remains a challenge. Herein, industrial lignin is fractionated by an organic solvent to reduce its structural heterogeneity. Subsequently, the fractionated lignin samples are integrated with polyvinyl alcohol (PVA) to fabricate plastics characterized by uniform thickness and smooth surfaces. The resultant composite films exhibit tensile strength and strain up to 75 MPa and 1050%, respectively, which surpass state-of-the-art lignin-based bioplastics. The mechanism investigations reveal that the enhanced mechanical properties are due to the internal non-covalent interactions derived from the hydroxyl groups of lignin and PVA. Notably, the PVA/lignin films are biodegradable after 92 days' burial in soil. This study paves the way for the rational design of lignin-based biodegradable polymers as sustainable alternatives to conventional plastics.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138123"},"PeriodicalIF":7.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural characterization and antioxidant activity evaluation of a polysaccharide from pink Auricularia cornea.
IF 7.7 1区 化学
International Journal of Biological Macromolecules Pub Date : 2025-01-01 Epub Date: 2024-11-28 DOI: 10.1016/j.ijbiomac.2024.138149
Lei Ye, Yu Huang, Lingzi Zhang, Xin Li, Bo Zhang, Xuezhen Yang, Jianhua Luo, Hongping Liu, Xiaoping Zhang, Chuan Song, Zonghua Ao, Caihong Shen, Wei Tan, Xiaolin Li
{"title":"Structural characterization and antioxidant activity evaluation of a polysaccharide from pink Auricularia cornea.","authors":"Lei Ye, Yu Huang, Lingzi Zhang, Xin Li, Bo Zhang, Xuezhen Yang, Jianhua Luo, Hongping Liu, Xiaoping Zhang, Chuan Song, Zonghua Ao, Caihong Shen, Wei Tan, Xiaolin Li","doi":"10.1016/j.ijbiomac.2024.138149","DOIUrl":"10.1016/j.ijbiomac.2024.138149","url":null,"abstract":"<p><p>An acidic polysaccharose (YL-D2N2) was isolated from crude polysaccharides of pink Auricularia cornea and characterized for its structural and antioxidant properties. YL-D2N2 consists of fucose, galactose, glucose, xylose, mannose and glucuronic acid in a molar ratio of 0.85: 1.50: 4.44: 27.52: 46.56: 19.13. It has a number-average molecular weight of about 52.811 kDa and a weight-average molecular weight of about 135.457 kDa. Structural characterization showed that YL-D2N2 consists of nine residues (Xylp-(1→, GlcpA-(1→, →2)-Xylp-(1→, →3)-Galp-(1→, →3)-Manp-(1→, →4)-GlcpA-(1→, →2,3)-Manp-(1→, →3,4)-Glcp-(1→, →3,6)-Manp-(1→), with a backbone of →3)-β-D-Manp-(1→, →2,3)-α-D-Manp-(1→, →3,6)-α-D-Manp-(1 → and side chains containing β-D-Xylp-(1 → and α-D-GlcpA-(1→. Notably, YL-D2N2 exhibits significant radical scavenging activity for superoxide anions, reaching 50.82 ± 0.64 % at a concentration of 3.2 mg/mL. Overall, YL-D2N2 exhibits a unique chemical structure and specialized applications for targeting superoxide anion radicals, providing valuable insights for further exploration of its structure-activity relationship.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"284 Pt 1","pages":"138149"},"PeriodicalIF":7.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chitosan/sodium alginate/ethyl cellulose-based multilayer film incorporated with l-ascorbic acid for improved barrier and antioxidant properties.
IF 7.7 1区 化学
International Journal of Biological Macromolecules Pub Date : 2025-01-01 Epub Date: 2024-11-28 DOI: 10.1016/j.ijbiomac.2024.138169
Yasir Abbas Shah, Saurabh Bhatia, Ahmed Al-Harrasi, Talha Shireen Khan
{"title":"Chitosan/sodium alginate/ethyl cellulose-based multilayer film incorporated with l-ascorbic acid for improved barrier and antioxidant properties.","authors":"Yasir Abbas Shah, Saurabh Bhatia, Ahmed Al-Harrasi, Talha Shireen Khan","doi":"10.1016/j.ijbiomac.2024.138169","DOIUrl":"10.1016/j.ijbiomac.2024.138169","url":null,"abstract":"<p><p>A bioactive multilayer film (ML) loaded with l-Ascorbic acid (AA) was developed using chitosan (CH), sodium alginate (SA), and ethyl cellulose (EC). Various properties of the films, including morphological, hydrophobic, barrier, mechanical, optical, and antioxidant characteristics, were evaluated and compared to those of monolayer films made from each biopolymer. The cross-sectional analysis via scanning electron microscopy revealed the successful preparation of the ML film with layering of the different biopolymers. For the ML film the resulting water contact angle was observed with an average of 73.86° and the film showed water resistant properties as compared to the individual CH and SA films. The ML film showed the lowest water vapor transmission rate (WVTR) at 54.99 g·d<sup>-1</sup>·m<sup>-2</sup> as compared to the individual films. Moreover, the ML film had the highest tensile strength at 0.56 MPa as compared to the mono-layer films including CH, SA, and EC with TS values of 0.33, 0.24 and 0.17 MPa, respectively. Furthermore, the AA-loaded ML film exhibited significantly higher DPPH scavenging activity at 66.20 %. These findings suggest that the ML film, due to its superior barrier, mechanical, and antioxidant properties has the potential for the applications in active food packaging.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138169"},"PeriodicalIF":7.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elucidating the genetic basis of bulb-related traits in garlic (Allium sativum) through genome-wide association study. 通过全基因组关联研究阐明大蒜(Allium sativum)鳞茎相关性状的遗传基础。
IF 7.7 1区 化学
International Journal of Biological Macromolecules Pub Date : 2025-01-01 Epub Date: 2024-11-22 DOI: 10.1016/j.ijbiomac.2024.137842
Yamei Wang, Wenjing Han, Taotao Wang, Chunying Jia, Jiajia Liu, Xiaorong Fan, Jingguang Chen
{"title":"Elucidating the genetic basis of bulb-related traits in garlic (Allium sativum) through genome-wide association study.","authors":"Yamei Wang, Wenjing Han, Taotao Wang, Chunying Jia, Jiajia Liu, Xiaorong Fan, Jingguang Chen","doi":"10.1016/j.ijbiomac.2024.137842","DOIUrl":"10.1016/j.ijbiomac.2024.137842","url":null,"abstract":"<p><p>The genetic architecture of garlic bulb related traits were still not well elucidated due to its big and complex genome. In this study, genotyping-by-sequencing (GBS) in 163 garlic accessions mainly from China were conducted. All the 163 garlic accessions were divided into three subpopulations, and largely consistent with geographic origins. Genome-wide association study (GWAS) was conducted for 5 garlic bulb related traits across four environments. Totally, 26 significantly loci were identified in two or more environments and located within or near 431 genes, and explain 14.0-31.7 % of the phenotypic variances. Among these, qBW5.1 was nearly with the qBH5.1. Four loci were reported previously, whereas the remaining 22 are likely to be new. Gene ontology enrichment analysis showed that the candidate genes were significantly enriched in metabolic process, biosynthetic process and catalytic activity. Nine candidate genes encode the zinc finger domain-containing protein, serine/threonine-protein kinase, peroxygenase, auxin-induced protein, ethylene-responsive transcription and E3-Ubiquitin protein ligases were identified and validated. Additionally, a meaningful achievement is one kompetitive allele-specific PCR marker, Kasp_chr7_BW for bulb weight were successfully developed and validated in a diverse panel. These results uncover the genetic mechanism of garlic bulb related traits and provide accessions and KASP markers for further garlic molecular breeding.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"137842"},"PeriodicalIF":7.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combination transcriptomic and metabolomic reveal deterioration of the blue honeysuckle (Lonicera caerulea L.) fruit and candidate genes regulating metabolism in the post-harvest stage. 转录组学和代谢组学的结合揭示了蓝色金银花(Lonicera caerulea L.)果实的变质以及采后阶段调节代谢的候选基因。
IF 7.7 1区 化学
International Journal of Biological Macromolecules Pub Date : 2025-01-01 Epub Date: 2024-11-26 DOI: 10.1016/j.ijbiomac.2024.138074
Jing Chen, Chunlin Fu, Haoyu Wang, Xueqing Sun, Ke Ma, Hao Yang, Dong Qin, Junwei Huo, Huixin Gang
{"title":"Combination transcriptomic and metabolomic reveal deterioration of the blue honeysuckle (Lonicera caerulea L.) fruit and candidate genes regulating metabolism in the post-harvest stage.","authors":"Jing Chen, Chunlin Fu, Haoyu Wang, Xueqing Sun, Ke Ma, Hao Yang, Dong Qin, Junwei Huo, Huixin Gang","doi":"10.1016/j.ijbiomac.2024.138074","DOIUrl":"10.1016/j.ijbiomac.2024.138074","url":null,"abstract":"<p><p>Blue honeysuckle, a new berry with high nutritional value, possesses typical berry postharvest properties, including extreme perishability, rapid quality loss, and high sensitivity to microbial infections. At present, the underlying mechanisms of postharvest quality deterioration, senescence, and low-temperature regulation remain largely unknown. This study aimed to elucidate the metabolic shifts and genetic regulation underlying the preservation or deterioration of blue honeysuckle during storage at room temperature (25 °C) and low temperature (4 °C). Storage at 4 °C inhibited fruit decay and preserved better visual quality, weight, firmness, and total soluble solid and acid contents. We identified 24 key differentially accumulated metabolites that specifically changed during the qualitative shift at room temperature and were effectively regulated by 4 °C. Commonly associated metabolites, sorbitol, succinic acid, malic acid, naringenin, pinobanksin, and taxifolin, characterize the deterioration of blue honeysuckle. These metabolites were integrated with transcriptomic data for weighted correlation network analysis (WGCNA). Regulatory networks were used for the identification of key genes and transcription factors (TFs) influencing sugar, organic acid, flavonoid, and phenolic acid metabolism during storage. The findings provide insight into metabolic regulation and the improvement of flavor in postharvest blue honeysuckle fruit.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138074"},"PeriodicalIF":7.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of ultrasonic-alkali integrated extraction combined with Mannesi reaction on the antimicrobial properties of rice straw lignin and enhancement strategies. 超声波-碱综合萃取结合曼内斯反应对稻草木质素抗菌性能的影响及增强策略。
IF 7.7 1区 化学
International Journal of Biological Macromolecules Pub Date : 2025-01-01 Epub Date: 2024-11-26 DOI: 10.1016/j.ijbiomac.2024.138047
Xiaoying Zhang, Fang Duan, Yue Su, Mengyu Wang, Jun Wang
{"title":"Effects of ultrasonic-alkali integrated extraction combined with Mannesi reaction on the antimicrobial properties of rice straw lignin and enhancement strategies.","authors":"Xiaoying Zhang, Fang Duan, Yue Su, Mengyu Wang, Jun Wang","doi":"10.1016/j.ijbiomac.2024.138047","DOIUrl":"10.1016/j.ijbiomac.2024.138047","url":null,"abstract":"<p><p>Lignin is one of the most abundant and underused biopolymers in nature with limited antimicrobial activities. Herein, this work aimed to enhance the antimicrobial activity of lignin extracted from waste rice straw by ultrasonic-alkali integrated extraction (USP-AT) and modify the alkali lignin through Mannich reaction to improve its antimicrobial properties. The effects of ultrasonic pretreatment (USP) time on the chemical structure, morphology, antioxidant, and antibacterial activities of lignin were studied. The results demonstrated that the total phenolic content of USP-AT lignin was higher than that of lignin extracted by alkali treatment. Moreover, the antioxidant activity of USP-AT lignin was increased by 49.69 %-69.42 %. The antibacterial activity of USP-AT lignin against Escherichia coli and Staphylococcus aureus increased by more than 40 %. However, the antibacterial capacity of USP-AT lignin is far from meeting the requirements of antibacterial food packaging. The alkali lignin was modified by Mannich reaction in order to improve its antimicrobial properties against common spoilage microorganisms or pathogenic bacteria in food and packaging. The modified USP-AT lignin exhibit remarkable antimicrobial capacities to representative bacteria, molds, and yeasts. The antifungal capacity of modified USP-AT lignin against A. niger and P. citrinum were improved by more than 40 %.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138047"},"PeriodicalIF":7.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studying the role of thrombomodulin-plasminogen interaction in spatial and interfacial invasion of melanoma metastatic progression. 研究血栓调节蛋白-血浆蛋白酶相互作用在黑色素瘤转移进展的空间和界面侵袭中的作用。
IF 7.7 1区 化学
International Journal of Biological Macromolecules Pub Date : 2025-01-01 Epub Date: 2024-11-24 DOI: 10.1016/j.ijbiomac.2024.138053
Thi Kim Ngan Ngo, Hua-Lin Wu, Cheng-Hsiang Kuo, Ting-Yuan Tu
{"title":"Studying the role of thrombomodulin-plasminogen interaction in spatial and interfacial invasion of melanoma metastatic progression.","authors":"Thi Kim Ngan Ngo, Hua-Lin Wu, Cheng-Hsiang Kuo, Ting-Yuan Tu","doi":"10.1016/j.ijbiomac.2024.138053","DOIUrl":"10.1016/j.ijbiomac.2024.138053","url":null,"abstract":"<p><p>Thrombomodulin (TM), a transmembrane glycoprotein, has emerged as a key factor in the metastatic spread of various cancers, including malignant melanoma. Despite its recognized significance, the underlying mechanisms of TM's involvement in enhancing metastasis remain incompletely understood. This study addresses this knowledge gap by utilizing spatial and interfacial invasion models in vitro to investigate the effect of the interaction between TM and plasminogen (Plg) on melanoma invasion. While it is well established that Plg induces a chain reaction in the plasmin system, leading to the activation of metalloproteases that promote tumor cell invasion and metastasis, this study is the first to demonstrate that TM binding to Plg can enhance these activations in spatial and interfacial invasion models in vitro. These results highlight the potential of TM as a crucial target for the development of drugs aimed at significantly inhibiting melanoma metastasis and improving patient survival.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138053"},"PeriodicalIF":7.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信