International Journal of Biological Macromolecules最新文献

{"title":"Corrigendum to \"TIMP1 and PKM drive immunosuppression and metabolic remodeling to promote colorectal cancer progression through integrated multi-omics analysis\" [International Journal of Biological Macromolecules; Volume: 360 Issue: May 2026; Article number: 151944; DOI: https://doi.org/10.1016/j.ijbiomac.2026.151944].","authors":"Yukai Wang, Wei Zhang, Yongshuo Liu, Xiaolong Tang","doi":"10.1016/j.ijbiomac.2026.152194","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.152194","url":null,"abstract":"","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"152194"},"PeriodicalIF":8.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and characterization of lanthanide-alginate-Ag nanocomposites with enhanced catalytic dye degradation, hydrogen evolution, and antimicrobial activity.","authors":"Samira M Alsawqaee, Zainab M Hritani, Esraa M Bakhsh, Kalsoom Akhtar, Sher Bahadar Khan","doi":"10.1016/j.ijbiomac.2026.152395","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.152395","url":null,"abstract":"<p><p>In this study, hydrogel beads were fabricated by ionic gelation of sodium alginate (Na-Alg) blended with Catharanthus roseus extract, which were subsequently incorporated with various lanthanide nitrate salts (lanthanum(III) nitrate, yttrium(III) nitrate, praseodymium(III) nitrate, thulium(III) nitrate, dysprosium(III) nitrate, erbium(III) nitrate, and ytterbium(III) nitrate) followed by in situ generation of silver nanoparticles (AgNPs) to yield Ln-Ag nanocomposite (Ln-Ag NC) beads. This approach leverages the robust coordination between lanthanide ions and alginate together with the surface reactivity of AgNPs to enable synergistic performance. The nanocomposites were characterized using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM-EDX), X-ray diffraction (XRD), zeta potential analysis, and X-ray photoelectron spectroscopy (XPS), confirming effective coordination and the formation of stable, well-dispersed nanostructures. The Ln-Ag NC beads were evaluated for NaBH₄-assisted reduction of organic pollutants including methyl orange (MO), methylene blue (MB), acridine orange (ArO), and 4-nitrophenol (4-NP), with yttrium‑silver NCs and praseodymium‑silver NCs exhibiting superior performance characterized by rapid decolorization, high apparent rate constants, and excellent recyclability over multiple cycles. Hydrogen generation via NaBH₄ hydrolysis showed dysprosium‑silver NCs beads as highly efficient catalysts, with hydrogen generation rates strongly dependent on catalyst loading, NaBH₄ concentration, temperature, and solvent. Furthermore, the Ln-Ag NC beads demonstrated pronounced antimicrobial activity against Gram-positive, Gram-negative bacterial, and fungal strains through colony-forming unit (CFU) reduction assays, attributed to synergistic interactions among AgNPs, lanthanide ions, Catharanthus roseus extract components, and the porous Na-Alg network, enabling high efficacy at reduced silver content.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"152395"},"PeriodicalIF":8.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable oxidized sodium alginate/gelatin (OSA/Gel) hydrogel loaded with MgO/SZS for ion-mediated osteogenesis and macrophage polarization.","authors":"Haiyu Li, Xianghua Wang, Jiangjie Tang, Ruoyu Ning, Liangjian Chen","doi":"10.1016/j.ijbiomac.2026.152155","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.152155","url":null,"abstract":"<p><p>Bone defect healing remains challenging due to trauma-associated microenvironmental disruption, persistent inflammation, and impaired coupling between bone formation and resorption. Here, we developed an injectable, biodegradable oxidized sodium alginate/gelatin (OSA/Gel) hydrogel with tunable gelation kinetics, favorable mechanical performance, and high shape fidelity for defect filling. By incorporating magnesium oxide (MgO) and Sr₂ZnSi₂O₇ (SZS) at different ratios, the formulation was optimized and its cytocompatibility and osteoimmunomodulatory activity were evaluated in vitro and in vivo. The hydrogel can be delivered minimally invasively to irregular defects and rapidly gels in situ into a porous three-dimensional scaffold, enabling sustained release of bioactive ions (Mg²⁺, Zn²⁺, Si⁴⁺, and Sr²⁺). These ionic cues promoted osteogenic responses in MC3T3-E1 cells, as indicated by enhanced osteogenesis-related gene expression, increased alkaline phosphatase activity, and mineral deposition, and were concurrently associated with a shift of RAW264.7 macrophages toward a pro-regenerative M2 phenotype. In a rabbit calvarial defect model, the OSA/Gel-MgO/SZS hydrogel induced early osteoid-like tissue deposition and promoted the formation of low-mineral-density newly formed bone spanning the defect margins and extending toward the central region compared with controls. Overall, the OSA/Gel hydrogel containing 1.0% MgO and 0.5% SZS promoted bone regeneration, accompanied by enhanced osteogenic activity and a pro-regenerative immune response, demonstrating strong potential as a functional biomaterial for bone defect repair.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"152155"},"PeriodicalIF":8.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An advanced strategy for wound healing: Developing multifunctional β-chitosan dressings from squid pen waste.","authors":"Yingying He, Chang Gao, Hancheng Zhao, Qingsong Huang, Changfeng Qu, Hongmei Li, Peng Wang, Jinlai Miao","doi":"10.1016/j.ijbiomac.2026.152386","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.152386","url":null,"abstract":"<p><p>Wounds, particularly chronic ones, pose significant clinical challenges due to their persistent nature and high risk of complications, which severely compromise patient quality of life and impose substantial socioeconomic burdens. This study presents a novel and sustainable strategy for advanced wound management by developing multifunctional dressing platforms based on β-chitosan (β-CS) derived from squid pen waste. An optimized biochemical extraction process was developed to obtain high-purity β-CS with suitable crystallinity and an elevated deacetylation degree. To harness these properties, β-CS was formulated with thermoresponsive Poloxamer 407 (P407), yielding two innovative wound healing systems: an in-situ forming film (CSPF) and a fast-powder (CSPP). To fully exploit the inherent bioactivity of β-CS, two novel wound healing platforms, namely an in-situ formed composite film (CSPF) and fast-deployable composite powder (CSPP), were fabricated by integrating β-CS with thermosensitive Poloxamer 407 (P407). In vitro characterization revealed that both formulations exhibited potent hemostatic capacity, broad-spectrum antibacterial activity, and outstanding hemocompatibility. In a murine full-thickness wound model, CSPF and CSPP significantly accelerated wound closure, enhanced collagen deposition, and promoted neovascularization. These dressings attenuated early inflammation through downregulation of key pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), while activating the TGF-β/β-catenin pathway to facilitate fibroblast-to-myofibroblast transition and extracellular matrix remodeling. Furthermore, CSPF/CSPP enhanced VEGF-mediated angiogenesis, as evidenced by increased CD31⁺ microvessel density. By converting marine waste into bioactive therapeutics, this work advances sustainable biomaterial development and shifts wound care from passive coverage to active biological intervention.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"152386"},"PeriodicalIF":8.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted liposomal epigallocatechin delivery for Alzheimer's disease: Effect on amyloid β fibrillation and neutralization of free radicals.","authors":"Stéphanie Andrade, Ângela Ferreira, Maria João Ramalho, Maria do Carmo Pereira, Joana Angélica Loureiro","doi":"10.1016/j.ijbiomac.2026.152399","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.152399","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a neurodegenerative condition marked by amyloid β (Aβ) plaque accumulation, contributing to cognitive decline. Epigallocatechin (EGC) has shown potential in preventing Aβ aggregation and disrupting fibrils, but its low bioavailability and poor blood-brain barrier (BBB) penetration limit its therapeutic use. To address these challenges, this study introduces the first functionalized nanosystem developed for the EGC delivery. Liposomal EGC was optimized and conjugated with transferrin (Tf), given literature evidence supporting its potential role in BBB-targeting strategies. The optimal formulation exhibited a mean diameter of 127 ± 14 nm, a polydispersity index of 0.20 ± 0.02, a zeta potential of -0.9 ± 0.3 mV, and an encapsulation efficiency of 20 ± 3%, properties that were maintained after 1 month of storage at 4 °C. Moreover, the nanosystem exhibited a controlled and sustained release, achieving 77 ± 11% release over 9 days. In terms of therapeutic activity, the nanoformulation showed an antioxidant capacity of 53 ± 6%, demonstrating its potential to neutralize free radicals, a key factor in AD progression. Furthermore, targeted liposomal EGC completely inhibited Aβ fibrillation, as demonstrated by thioflavin T assays. Data revealed a reduction in parallel β-sheet content from 44 ± 4% to 33 ± 5% and an increase in α-helices from 31 ± 5 to 45 ± 4%, suggesting inhibition of fibril formation. Additionally, Tf conjugation enhanced liposome uptake by endothelial cells without inducing cytotoxicity. These findings support the potential of this nanosystem as a promising platform for further investigation in AD.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"152399"},"PeriodicalIF":8.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polydopamine-assisted polyethyleneimine functionalization of bacterial cellulose aerogel for efficient adsorptive removal of Cu(II) and organic dyes.","authors":"Yihong Yang, Ruiying Liao, Tengxin Huo, Yongling Xu, Huaiwen He","doi":"10.1016/j.ijbiomac.2026.152416","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.152416","url":null,"abstract":"<p><p>Direct functionalization of biopolymer aerogels often encounters steric agglomeration and pore blockage, which can significantly limit the accessibility of active sites for water purification. To address this challenge, a robust composite aerogel (BC-PDA-PEI) was engineered via a stepwise assembly strategy, utilizing polydopamine (PDA) as an interfacial adhesion layer to uniformly anchor polyethyleneimine (PEI) onto a bacterial cellulose skeleton. Structural characterization demonstrated that the PDA intermediate effectively suppresses the phase separation of PEI, thereby preventing bulk agglomeration and facilitating a thin, nanoscale coating. The resulting composite exhibited broad-spectrum removal performance, achieving maximum adsorption capacities (q_m) of 93.52 mg/g for Cu(II) (as a model heavy metal), 615.02 mg/g for the anionic dye Congo Red, and 92.22 mg/g for the cationic dye Methylene Blue. Adsorption kinetics and isotherms were best described by the pseudo-second-order and Langmuir models, respectively, suggesting a monolayer-type adsorption mechanism. Post-adsorption FTIR/XPS analyses, together with the surface-charge trend, suggested pollutant-dependent interaction pathways: abundant amine groups contribute to the capture of Cu(II) via strong coordination, while the net positive surface character of BC-PDA-PEI favors the electrostatic removal of anionic dyes. This work presents a practical interfacial modification route to address agglomeration and pore occlusion issues in biopolymer aerogel functionalization, leading to the development of a sustainable adsorbent for the efficient removal of heavy metal ions and organic dyes from wastewater.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"152416"},"PeriodicalIF":8.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The multifaceted oncogenic role of long intergenic non-coding RNA 01614 in mediating tumor progression and therapeutic resistance: A review.","authors":"Liangtao Chen, Fubin Wei, Jiahe Zhang, Tengyue Zhang, Haoran Liu, Yanhua Wang","doi":"10.1016/j.ijbiomac.2026.152421","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.152421","url":null,"abstract":"<p><p>The escalating global burden of human malignancies and frequent therapeutic resistance necessitate the urgent identification of novel molecular targets. Recently, long intergenic non-coding RNA 01614 (LINC01614) has emerged as a pan-cancer oncogenic driver whose functional roles have been experimentally validated across at least ten malignancies. This review comprehensively summarizes the functions, regulatory mechanisms, and clinical significance of LINC01614 in cancer. Functionally, LINC01614 drives multidimensional malignant phenotypes, encompassing epithelial-mesenchymal transition (EMT), metabolic reprogramming, and the immunosuppressive remodeling of the tumor microenvironment (TME). Mechanistically, its highly orchestrated regulatory network initiates with upstream transcriptional activation by factors like STAT1 and SP1, followed by its core function as a competing endogenous RNA (ceRNA) to sequester multiple tumor-suppressive microRNAs. This functionally hyperactivates canonical downstream signaling cascades, including the PI3K/Akt, Wnt/β-catenin, and TGF-β pathways. Clinically, LINC01614 upregulation consistently correlates with aggressive clinicopathological features, potential metastasis, and recalcitrant chemoresistance. By synthesizing these diverse dimensions alongside current translational bottlenecks, this review paper highlights LINC01614 as a highly promising diagnostic biomarker and an actionable therapeutic vulnerability for overcoming drug resistance in precision oncology.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"152421"},"PeriodicalIF":8.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular basis of BACE1 modulation revealed by machine learning, molecular simulations, and experimental validation.","authors":"Muhammad Shahab, Jiazhuo Xiao, Jiaojiao Wang, Zunnan Huang","doi":"10.1016/j.ijbiomac.2026.152409","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.152409","url":null,"abstract":"<p><p>Alzheimer's disease (AD) remains one of the most prevalent and debilitating neurodegenerative disorders worldwide, with no currently available disease-modifying treatments. β-site amyloid precursor protein cleaving enzyme 1 (BACE1) catalyzes the rate-limiting step in amyloid-β (Aβ) production and represents a validated therapeutic target for AD intervention. In this study, we developed an integrated computational framework combining machine learning-based virtual screening, molecular docking, and molecular dynamics simulations with experimental validation using CCK-8 assays and Western blot analysis to identify novel BACE1 inhibitors from a natural product library. A curated dataset of experimentally validated BACE1 inhibitors retrieved from the ChEMBL database was used to construct 36 classification models based on three molecular fingerprint representations MACCS Keys, ECFP4, and Topological Torsion in combination with four machine learning algorithms such as Support Vector Machine (SVM), Random Forest (RF), Decision Tree (DT), and Extreme Gradient Boosting (XGBoost). Among all developed models, the SVM model using ECFP4 fingerprints achieved the best predictive performance, with an external test set accuracy of 0.91 and a Matthews Correlation Coefficient (MCC) of 0.78. The optimized models were subsequently applied to screen 4779 natural product compounds from the MedChemExpress library using a consensus prediction strategy. Promising hits were evaluated by molecular docking against the BACE1 crystal structure (PDB: 6PZ4), and top-ranked candidates were subjected to 200 ns molecular dynamics simulations followed by MM/GBSA binding free energy calculations. Among the identified candidates, HY-N7141 exhibited the most favorable docking score (-9.04 kcal/mol) and binding free energy (ΔG = -67.30 kcal/mol), driven predominantly by strong van der Waals interactions with key catalytic residues. Structural stability analysis confirmed that the majority of protein-ligand complexes maintained stable conformations throughout the simulations. Experimental validation in SH-SY5Y human neuroblastoma cells further assessed the effects of selected compounds on BACE1 protein expression. Collectively, these findings demonstrate the utility of integrating machine learning with structure-based approaches for accelerating the discovery of potent BACE1 inhibitors, and present several promising candidates warranting further preclinical investigation.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"152409"},"PeriodicalIF":8.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Template-based preparation of W/O/W-type spray-dried probiotic microcapsules using pectin-zein pickering emulsion.","authors":"Yanxiao Liang, Xinxin Cheng, Fuhui Ren, Yanwei Zhang, Peng Wu, Dongxiao Sun-Waterhouse","doi":"10.1016/j.ijbiomac.2026.152424","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.152424","url":null,"abstract":"<p><p>Probiotics are vital to human health, yet their viability is susceptible to adverse conditions during food processing, storage, and the digestive process. Currently, spray-dried emulsified microencapsulation technology is widely employed for the preservation of probiotics and the development of related products. Nevertheless, challenges persist, including low encapsulation efficiency, premature release, and low probiotic survival rates. Herein, a water-in-oil-in-water (W/O/W) Pickering emulsion (PE-ZPe) stabilized by pectin-zein complex nanoparticles (PEC-ZNP) was developed as a template for encapsulating Bifidobacterium longum, thereby achieving high survival rates and targeted release. Results from FTIR, XRD, CLSM, and LF-NMR indicated that PEC and ZNP form a more stable outer aqueous interface layer through electrostatic interactions, hydrogen bonding and hydrophobic interactions. The prepared PE-ZPe exhibited excellent storage stability and tolerance to the gastrointestinal environment. The shear-thinning properties of the emulsion enabled it to pass smoothly through the nozzle during spray drying, effectively preventing blockages. Following spray drying, the PE-ZPe microcapsules exhibited a low moisture content, significantly reduced sticking or clumping. Their stable bilayer core-shell structure effectively minimised the logarithmic reduction in Bifidobacterium longum. Results from storage and simulated gastrointestinal experiments indicate that the viable count of Bifidobacterium longum within the microcapsules remained consistently above 1 × 10⁶ CFU/g at 4 °C for 28 days, confirming their targeted release in the intestinal environment. In summary, this study has successfully addressed the key challenges associated with traditional spray-drying methods for probiotic microencapsulation, including poor stability, these findings provide valuable insights for the development and scalable production of probiotic products.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"152424"},"PeriodicalIF":8.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Phytic acid-iron synergized straw cellulose-based polyurethane biocomposite for flame-retardant applications\" [Int. J. Biol. Macromol. 361 (2026) 152005].","authors":"Beibei Wang, Sentao Wei, Licheng Zhou, Guochao Yang, Jian Wang, Le Xu, Kushairi Mohd Salleh, Qun Wu","doi":"10.1016/j.ijbiomac.2026.152183","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.152183","url":null,"abstract":"","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"152183"},"PeriodicalIF":8.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}