International Journal of Biological Macromolecules最新文献_第10页

A natural carboxylated sisal fiber/chitosan/kaolin porous sponge for rapid and effective hemostasis. 天然羧化剑麻纤维/壳聚糖/高岭土多孔海绵，可快速有效止血。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2024-11-15 DOI: 10.1016/j.ijbiomac.2024.137618

Tang Shuo, Niu Haoting, Wang Yuqing, Jiang Liuyun, Hu Xiang

{"title":"A natural carboxylated sisal fiber/chitosan/kaolin porous sponge for rapid and effective hemostasis.","authors":"Tang Shuo, Niu Haoting, Wang Yuqing, Jiang Liuyun, Hu Xiang","doi":"10.1016/j.ijbiomac.2024.137618","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2024.137618","url":null,"abstract":"To improve chitosan hemostasis, carboxylated sisal fiber and kaolin were introduced to obtain carboxylated sisal fiber/chitosan/kaolin (SF/CS/K) composite sponges (the weight ratio of 3: 3:4, 4:4:2, 5:5:0) by freeze-drying method. The results showed that the ionic cross-linking of the carboxylated sisal fiber with chitosan and kaolin-loading endowed the composite sponges with not only oriented groove porous structure, high mechanical strength, porosity, water absorption and compress recovery, but also suitable biodegradation, good cytocompatibility, hemocompatibility, protein adsorption, antibacterial activity. Especially, compared with commercial gelatin hemostatic sponges, the composite sponge of SF/CS/K displayed the better coagulation ability and hemostatic effect, and animal experiments further demonstrated that the bleeding amount and hemostatic time of SF/CS/K were greatly reduced in rat hemostatic models of tail amputation, femoral vein trauma and liver injury, owing to the synergistic hemostatic effect of chitosan, kaolin and sisal fiber, as well as the groove porous structure, which endowed them with strong adhesion for red blood cells. Conclusively, SF/CS/K2 composite sponge had the best hemostatic effect because of the most appropriate component ratio, which is a novel promising natural hemostatic sponge for effective and rapid hemostasis in deep massive bleeding sites.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"137618"},"PeriodicalIF":7.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential scanning calorimetric domain dissection for HSA upon interaction with Bortezomib: Unveiling the binding dynamics. HSA 与硼替佐米相互作用时的差示扫描量热结构域剖析：揭示结合动力学

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2024-11-15 DOI: 10.1016/j.ijbiomac.2024.137728

Bagher Davaeil, Anita Saremipour, Faezeh Moosavi-Movahedi, S Mohsen Asghari, Ali Akbar Moosavi-Movahedi

{"title":"Differential scanning calorimetric domain dissection for HSA upon interaction with Bortezomib: Unveiling the binding dynamics.","authors":"Bagher Davaeil, Anita Saremipour, Faezeh Moosavi-Movahedi, S Mohsen Asghari, Ali Akbar Moosavi-Movahedi","doi":"10.1016/j.ijbiomac.2024.137728","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2024.137728","url":null,"abstract":"Human serum albumin (HSA), a crucial plasma protein, plays a significant role in drug interactions within the bloodstream, bearing considerable clinical relevance. Bortezomib (BTZ) is a potent anti-cancer drug for multiple myeloma (MM) and mantle cell lymphoma (MC). The mechanism of BTZ transfer in the blood remains undetermined. This study aims to investigate the binding of BTZ to HSA using the techniques of differential scanning calorimetry (DSC), circular dichroism (CD), fluorescence spectroscopy, and computational methods such as molecular docking and molecular dynamics simulations. This study presents the thermal dissection of domain I (DI) of HSA by subjecting it to a temperature elevation of 79.2 °C (2 °C above Tm of DI) using DSC, which provides new information on the thermal behavior of HSA domains. Furthermore, the deconvolution analysis of the HSA thermogram in the absence and presence of BTZ revealed that the drug binding site is located in DI and impacts DII. The interaction between BTZ and HSA with a binding affinity (Kb) of 7.744±0.2 ×105 M-1 influences protein dynamics and reduces HSA's thermal stability by almost 1 °C. This study is crucial for predicting the pharmacokinetics and pharmacodynamics of BTZ, aiding in developing safer and more effective treatments for MM and MC.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"137728"},"PeriodicalIF":7.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MIL-101 magnetic nanocarrier for solid-phase delivery of doxorubicin to breast and lung cancer cells. 用于乳腺癌和肺癌细胞多柔比星固相给药的 MIL-101 磁性纳米载体。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2024-11-15 DOI: 10.1016/j.ijbiomac.2024.137615

Reza Taheri-Ledari, Mostafa Ghafori-Gorab, Sorour Ramezanpour, Mohammad Mahdavi, Maliheh Safavi, Ali Reza Akbarzadeh, Ali Maleki

{"title":"MIL-101 magnetic nanocarrier for solid-phase delivery of doxorubicin to breast and lung cancer cells.","authors":"Reza Taheri-Ledari, Mostafa Ghafori-Gorab, Sorour Ramezanpour, Mohammad Mahdavi, Maliheh Safavi, Ali Reza Akbarzadeh, Ali Maleki","doi":"10.1016/j.ijbiomac.2024.137615","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2024.137615","url":null,"abstract":"An efficient strategy for passive delivery of doxorubicin (DOX) to the breast (MDA-MB-231) and lung (A-549) cancer cells is presented and compared with MCF-10A normal breast cells. Two versions of a peptide structure (linear and cyclic) have been designed and assessed. The molecular dynamic simulations in Material Studio2017 exhibited a higher adsorption capacity for L2 (cyclic version) compared with the adsorption capacity of L1 (linear version) on the PG surface by electrostatic interactions between guanidine of arginine and -OH of PG. The prepared final product based on iron oxide nanoparticles and MIL-101(Fe) (formulated as DOX@Fe3O4/MIL-101-(C,L)C[RW]3) is characterized and the drug content has been estimated. The release profiles revealed an ultra-fast stimulus-sensitive model in acidic media, which corroborates a pH-triggered release. The in vitro assessments disclosed that aggregation of nanocargo around the cancer cells and resulted toxicity are more than the neat DOX in the same dosage as DOX@Fe3O4/MIL-101-CC[RW]3. The obtained distinguished features lie in ability to utilize a biocompatible nanocargo structure to release an appropriate dose of DOX in a controlled manner in the cancer cell environment. Moreover, the functionalization of MIL-101 using cyclic and linear peptides and their comparison is one of the important features of this project.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"137615"},"PeriodicalIF":7.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunomodulation of exopolysaccharide produced by Lacticaseibacillus rhamnosus ZFM216 in cyclophosphamide-induced immunosuppressed mice by modulating gut microbiota. 通过调节肠道微生物群，鼠李糖乳杆菌 ZFM216 产生的外多糖对环磷酰胺诱导的免疫抑制小鼠的免疫调节作用

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2024-11-15 DOI: 10.1016/j.ijbiomac.2024.137619

Liang Chen, Dong Wang, Wei Liu, Shaobo Zhou, Qing Gu, Tao Zhou

{"title":"Immunomodulation of exopolysaccharide produced by Lacticaseibacillus rhamnosus ZFM216 in cyclophosphamide-induced immunosuppressed mice by modulating gut microbiota.","authors":"Liang Chen, Dong Wang, Wei Liu, Shaobo Zhou, Qing Gu, Tao Zhou","doi":"10.1016/j.ijbiomac.2024.137619","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2024.137619","url":null,"abstract":"This study investigated the immunoregulatory activity of exopolysaccharides (EPS) produced by Lacticaseibacillus rhamnosus ZFM216 in immunosuppressed mice induced by cyclophosphamide (CTX). The results showed that EPS treatment effectively improved the body weight, immune organ index and splenic lymphocyte proliferation. EPS also mitigated the damage of immune organs, restored intestinal morphology, and regulated the levels of serum hemolysin and cytokines (e.g. TNF-α, INF-γ and IL-10). EPS promoted the release of NO, TNF-α, IL-1β, and IL-6 in RAW 264.7 cells, however, such effect was inhibited in the presence of inhibitors of TLR4 and MAPKs signaling pathways-related proteins, confirming that EPS achieved the immunomodulation by activating these two signaling pathways. Additionally, EPS, as a prebiotic, effectively improved the diversity of microbial communities, regulated the relative abundance of dominant microbial communities, restored CTX-induced gut microbiota dysbiosis, and promoted the production of short chain fatty acids (SCFAs) in the gut of mice. Thus, immunoregulatory effect of EPS could be attributed to its good ability to modulate the gut microbiota. EPS produced by L. rhamnosus ZFM216 has promising application as an ingredient of functional foods due to its potent probiotic effect.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"137619"},"PeriodicalIF":7.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Collaborative disposal of beryllium−containing wastewater with modified graphite@chitosan from waste lithium−ion batteries 利用废弃锂离子电池中的改性石墨@壳聚糖协同处理含铍废水。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2024-11-15 DOI: 10.1016/j.ijbiomac.2024.137698

Xu Zhao , Fang Hu , Xipeng Yang , Yige Sun , Guanqing Lin , Haoshuai Li , Zhiwu Lei , Yucheng Su , Khan Muhammad Yaruq Ali , Eming Hu , Hongqiang Wang , Qingliang Wang

{"title":"Collaborative disposal of beryllium−containing wastewater with modified graphite@chitosan from waste lithium−ion batteries","authors":"Xu Zhao , Fang Hu , Xipeng Yang , Yige Sun , Guanqing Lin , Haoshuai Li , Zhiwu Lei , Yucheng Su , Khan Muhammad Yaruq Ali , Eming Hu , Hongqiang Wang , Qingliang Wang","doi":"10.1016/j.ijbiomac.2024.137698","DOIUrl":"10.1016/j.ijbiomac.2024.137698","url":null,"abstract":"<div><div>In order to recover and effectively remove beryllium from beryllium-containing wastewater and relieve the environmental pressure caused by waste batteries. In this study, the gel material was synthesized based on the modified graphite material separated from the waste battery, and the graphite−@chitosan composite gel (CWBG@CH) was designed and synthesized. Interestingly, CWBG@CH has a maximum fitted adsorption capacity (Qemax) of 83.54 mg/g at pH = 6 and 35 °C. The adsorption process of CWBG@CH is controlled by surface complexation and electrostatic attraction. Strong coordination and synergistic adsorption between Be and the carbonic acid/hydroxyl group and phosphoric acid/amino group on CWBG@CH enhances the adsorption capacity and selectivity of CWBG@CH for Be. At the same time, the adsorption-desorption efficiency of the CWBG@CH in 5 times is >85 %. This discovery provides a direction for the recycling of graphite materials from waste batteries and indicates the great potential of CWBG@CH to remove Be(II) from aqueous solutions.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"283 ","pages":"Article 137698"},"PeriodicalIF":7.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of natural hydrogels consisting of oxidized dextran, quaternized chitosan and cuttlefish ink nanoparticles for treating diabetic oral ulcers. 构建由氧化右旋糖酐、季铵化壳聚糖和墨鱼墨汁纳米颗粒组成的天然水凝胶，用于治疗糖尿病口腔溃疡。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2024-11-15 DOI: 10.1016/j.ijbiomac.2024.137737

Jianan Song, Zhenni Geng, Xinrui Luan, Diya Zhang, Qiong Wang, Lai Pan, Xiaoyang Yu, Wei Dong, Dalei Wu, Shengye You

{"title":"Construction of natural hydrogels consisting of oxidized dextran, quaternized chitosan and cuttlefish ink nanoparticles for treating diabetic oral ulcers.","authors":"Jianan Song, Zhenni Geng, Xinrui Luan, Diya Zhang, Qiong Wang, Lai Pan, Xiaoyang Yu, Wei Dong, Dalei Wu, Shengye You","doi":"10.1016/j.ijbiomac.2024.137737","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2024.137737","url":null,"abstract":"Current approaches to managing diabetic oral ulcers are often inadequate in medical settings due to risks of bacterial contamination, oxidative harm, and hindered blood vessel growth during recovery. Here, we have developed a hydrogel (OQC2) consisting of oxidized dextran, quaternized chitosan, and melanin nanoparticles sourced from cuttlefish ink to effectively treat wounds from diabetic oral ulcers. Initially, by administering a straightforward local injection, a protection barrier forms over the mucosal injury, promptly stopping bleeding and neutralizing inflammatory agents. The OQC2 excels in innate antibacterial activity and can effectively remove reactive oxygen species, aiding in bacterial eradication and managing oxidative states, thereby hastening the wound's transition from inflammation to tissue growth. Moreover, the OQC2 features a three-dimensional structure made up of elements sourced from natural materials, potentially making it an excellent resource for providing structural and nutritional support to cells. This support encourages cell attachment, movement, and growth, as well as further blood vessel formation in the process of mucosal remodeling. Both in vitro and in vivo trials indicate that the OQC2 significantly speeds up the repair of mucosal wounds, presenting a viable option for treating diabetic oral ulcers.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"137737"},"PeriodicalIF":7.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of different extraction temperatures on the structural characteristics and antioxidant activity of polysaccharides from dandelion leaves. 不同提取温度对蒲公英叶多糖结构特征和抗氧化活性的影响

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2024-11-15 DOI: 10.1016/j.ijbiomac.2024.137726

Pei Chen, Ee Sang, Huanhuan Chen, Qi Meng, Huiping Liu

{"title":"Effects of different extraction temperatures on the structural characteristics and antioxidant activity of polysaccharides from dandelion leaves.","authors":"Pei Chen, Ee Sang, Huanhuan Chen, Qi Meng, Huiping Liu","doi":"10.1016/j.ijbiomac.2024.137726","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2024.137726","url":null,"abstract":"Dandelion polysaccharides contribute to a variety of biological activities. This study evaluated the effect of different extraction temperatures (4 °C and 80 °C) on the structural characteristics and antioxidant activity of dandelion leaf polysaccharides (DLP). The findings demonstrated that the extraction efficiency improved at the higher temperature, while molecular weight exist a trend of degradation with increasing extraction temperature. Ion chromatography (IC) analysis indicated that the polysaccharides DLP4 and DLP80 were structurally complex heteropolysaccharides mainly composed of galactose, arabinose, glucose and mannose, with galactose and arabinose dominating. FT-IR and methylation analysis revealed that DLP4 and DLP80 had similar chemical structures and branches. DLP4 contained a higher amount of 6-Galactose. Microstructure analysis showed that heat treatment caused conformational changes in DLP4 and DLP80. Both had excellent free radical scavenging ability including DPPH·, ABTS·+, OH· and reducing power. The Reactive Oxygen Species assay indicated that the protective effect of DLP4 against H2O2-induced oxidative damage in vitro was stronger than that of DLP80. Superoxide dismutase (SOD) and malondialdehyde (MDA) measurements also confirmed that the antioxidant effect of DLP4 was more prominent. Overall, low temperature extracted DLP can be used as an antioxidant in the areas of food, medicine and biomaterials.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"137726"},"PeriodicalIF":7.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of dynamic high-pressure microfluidization on the structural, emulsifying properties, in vitro digestion and antioxidant activity of whey protein isolate. 动态高压微流对分离乳清蛋白的结构、乳化性能、体外消化和抗氧化活性的影响。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2024-11-15 DOI: 10.1016/j.ijbiomac.2024.137720

Chen Wang, Han-Xing Wen, Su Yang, Chang-Yue Ma, Xu-Mei Wang, Zong-Cai Tu, Yan-Hong Shao, Jun Liu

{"title":"Effect of dynamic high-pressure microfluidization on the structural, emulsifying properties, in vitro digestion and antioxidant activity of whey protein isolate.","authors":"Chen Wang, Han-Xing Wen, Su Yang, Chang-Yue Ma, Xu-Mei Wang, Zong-Cai Tu, Yan-Hong Shao, Jun Liu","doi":"10.1016/j.ijbiomac.2024.137720","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2024.137720","url":null,"abstract":"The effects of dynamic high-pressure microfluidization (DHPM) on the structural, emulsifying properties, in vitro digestion and antioxidant activity of whey protein isolate (WPI) were investigated. The results demonstrated that WPI treated with 100 MPa DHPM exhibited superior emulsification performance. This can be attributed to the conformational changes induced by 100 MPa DHPM in WPI, leading to a transformation from disordered structures to ordered structures and an increased exposure of fluorophore such as tryptophan residues and hydrophobic groups, reduced aggregation state and particle size of WPI. These factors facilitated the migration of WPI towards the oil-water interface, resulting in the formation of a robust and compact adsorption layer which reduces interfacial tension and enhances emulsification stability. Furthermore, it was observed that while DHPM did not significantly affect the digestibility of WPI, it did enhance exposure to antioxidant amino acids in the digestive products thereby enhanced their antioxidant properties. In summary, structural modification induced by DHPM treatment enhanced both emulsification and antioxidant properties of WPI. These findings highlight the significant potential of DHPM treatment for enhancing the quality of meat products with an emulsion-type structure.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"137720"},"PeriodicalIF":7.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural characterization of an arabinogalactan rich fraction from Bauhinia forficata link leaves and evaluation of its effect on THP-1 macrophages. 洋紫荆叶片中富含阿拉伯半乳聚糖成分的结构特征及其对 THP-1 巨噬细胞作用的评估。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2024-11-15 DOI: 10.1016/j.ijbiomac.2024.137731

Giuliana Cozzella Campo-Grande, Jessica Boschini D'Agostin, Arquimedes Paixão de Santana Filho, Genilza da Silva Mello, Philippe Rodrigues Benedetti, Wellington Felipe Dos Santos, Fernanda Fogagnoli Simas, Thales Ricardo Cipriani

{"title":"Structural characterization of an arabinogalactan rich fraction from Bauhinia forficata link leaves and evaluation of its effect on THP-1 macrophages.","authors":"Giuliana Cozzella Campo-Grande, Jessica Boschini D'Agostin, Arquimedes Paixão de Santana Filho, Genilza da Silva Mello, Philippe Rodrigues Benedetti, Wellington Felipe Dos Santos, Fernanda Fogagnoli Simas, Thales Ricardo Cipriani","doi":"10.1016/j.ijbiomac.2024.137731","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2024.137731","url":null,"abstract":"Bauhinia forficata is a medicinal plant known as cow's paw, used for many purposes. Although there are studies that aimed to elucidate compounds from the plant leaves, there is no information about its polysaccharides. This study intended to obtain a polysaccharide rich fraction from its leaves, structurally characterize the water-soluble polysaccharides, as well as evaluate their effect on THP-1 cells. From the aqueous extract, followed by purification processes, a polysaccharide fraction (TCAS) was obtained, constituted mainly of arabinose and galactose. Bidimensional NMR (13C/1H, HSQC) and methylation analyses identified type I and type II arabinogalactans, arabinan and starch as the major polysaccharides of the fraction. TCA-S was then submitted to starch removal process and renamed as TCASα. TCASα (2 to 500 μg/mL) was not cytotoxic to THP-1-cells and exhibited an immunostimulatory effect by increasing the secretion of nitric oxide and both pro-inflammatory cytokine IL-1β and anti-inflammatory cytokine IL-10. Immunomodulatory effect on IL-6 secretion was observed when macrophages were treated with TCA-Sα at 500 μg/mL. Additionally, the ratio between the concentrations of pro and anti-inflammatory cytokines produced by LPS-treated cells was higher than that produced by LPS plus TCA-Sα treated ones, suggesting that the polysaccharide fraction could modulate the LPS inflammation effects.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"137731"},"PeriodicalIF":7.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel polydopamine-coated bacterial cellulose/g-C₃N₄ membrane for highly efficient photocatalytic degradation of methylene blue. 用于高效光催化降解亚甲基蓝的新型多巴胺包覆细菌纤维素/g-C3N4 膜。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2024-11-15 DOI: 10.1016/j.ijbiomac.2024.137738

Piti Charurungsipong, Bhumin Than-Ardna, Hathaikarn Manuspiya

{"title":"A novel polydopamine-coated bacterial cellulose/g-C3N4 membrane for highly efficient photocatalytic degradation of methylene blue.","authors":"Piti Charurungsipong, Bhumin Than-Ardna, Hathaikarn Manuspiya","doi":"10.1016/j.ijbiomac.2024.137738","DOIUrl":"10.1016/j.ijbiomac.2024.137738","url":null,"abstract":"Photocatalytic oxidation emerges as an eco-friendly approach for chemically degrading water-borne organic pollutants. Establishing a more sustainable process for synthesizing photocatalyst membranes with higher efficiency and reusability is crucial for advancing safe water remediation solutions. In this study, we present a novel photocatalytic membrane incorporating bacterial cellulose (BC), a naturally occurring biopolymer with an intricate fibrous network, and graphitic carbon nitride (g-C3N4), a visible light-responsive non-metal photocatalyst. The composite membrane is augmented with a coating of polydopamine (PDA), an amorphous polymeric layer derived from dopamine to enhance light absorption and reduce photoexcited charge recombination. The BC/g-C3N4/PDA membrane demonstrates a substantial improvement in methylene blue removal efficiency, up to 95.39 % within 150 min of irradiation. Moreover, the PDA-modified membrane exhibits noteworthy recyclability, retaining significant photodegradation ability for up to three cycles. This method offers an accessible and scalable approach to fabricating a highly effective photocatalyst composite membrane suitable for industrial applications.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"137738"},"PeriodicalIF":7.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0