International Journal of Biological Macromolecules最新文献_第9页

Conformational change induced by binding of Mn²⁺ ions activates SloR transcription factor in Streptococcus mutans.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2024-12-17 DOI: 10.1016/j.ijbiomac.2024.138828

Katarina Radman, Ivo Crnolatac, Nikola Bregović, Zoe Jelić Matošević, Pedro A Fernandes, Dalibor Merunka, Dijana Žilić, Ivo Piantanida, Ivana Leščić Ašler, Branimir Bertoša

{"title":"Conformational change induced by binding of Mn2+ ions activates SloR transcription factor in Streptococcus mutans.","authors":"Katarina Radman, Ivo Crnolatac, Nikola Bregović, Zoe Jelić Matošević, Pedro A Fernandes, Dalibor Merunka, Dijana Žilić, Ivo Piantanida, Ivana Leščić Ašler, Branimir Bertoša","doi":"10.1016/j.ijbiomac.2024.138828","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2024.138828","url":null,"abstract":"Streptococcus mutans, a bacterium commonly found in the human oral cavity, is considered the primary causative agent of dental caries. A key player in the pathophysiology of S. mutans is SloR, a 25-kDa metalloregulatory protein. SloR plays a crucial role in coordinating the uptake of essential metal ions, particularly manganese, with the transcription of the bacterium's virulence genes. To elucidate the molecular mechanism underlying the enhanced binding affinity of SloR to DNA upon Mn2+ ion binding, a combination of computational (QM and MD) and experimental (ITC, DSC, CD, EPR) methods have been employed. Computational simulations revealed that Mn2+ binding induces a conformational change of SloR, primarily affecting the positioning of its DNA-binding domains, bringing them to an appropriate position for DNA binding. Consequently, the protein's DNA binding affinity is modulated. Additionally, experimental findings indicate that the SloR monomer binds up to three Mn2+ ions and that the thermodynamic stability of SloR increases upon Mn2+ complexation. The presented computational results also suggest that Mn2+ binding at the primary binding sites is sufficient to trigger the observed conformational change in SloR.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138828"},"PeriodicalIF":7.7,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-performance delivery capsules co-assembled from lignin and chitosan with Avermectin for sustainable pest management.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2024-12-17 DOI: 10.1016/j.ijbiomac.2024.138894

Xuan Li, Yixin Yun, Yitong Wang, Wanbin Zhu, Quan Bu, Yaxun Fan, Hongliang Wang

{"title":"High-performance delivery capsules co-assembled from lignin and chitosan with Avermectin for sustainable pest management.","authors":"Xuan Li, Yixin Yun, Yitong Wang, Wanbin Zhu, Quan Bu, Yaxun Fan, Hongliang Wang","doi":"10.1016/j.ijbiomac.2024.138894","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2024.138894","url":null,"abstract":"Inexpensive biomass materials hold great potential for the development of green delivery systems aimed at improving the extremely low utilization efficiency of pesticides. However, current systems face challenges in achieving both high encapsulation rates and drug loading capacities. This study introduces a novel method using chitosan (CS) and sodium lignosulfonate (SL) to co-assemble with avermectin (AVM), a widely used hydrophobic pesticide, forming AVM-CS-SL micro-nano capsules. Engineered under optimized conditions of pH 5 and 40 °C, the capsules exhibit an AVM encapsulation efficiency of 84.27 % and a loading capacity of 90 %. The AVM-CS-SL capsules demonstrate multifunctional attributes that enhance pesticide application. The capsules, with an average diameter of 356 nm, facilitate stable embedding in leaf grooves and enable effective adhesion to leaf surfaces, thereby improving their resistance to wash-off by rain compared to conventional formulations. Their core-shell structure protects AVM from photodegradation, ensuring long-term stability and efficacy. The capsules also exhibit enhanced bioactivity, with higher mortality rates in Plutella xylostella larvae and low genotoxicity to Vicia faba plants. These findings highlight the strategy of developing multifunctional delivery systems by the co-assembled carrier materials with active ingredients, offering an effective solution for the sustainable development of society and environment.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138894"},"PeriodicalIF":7.7,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stretchable and self-healing carboxymethyl cellulose/polyacrylic acid conductive hydrogels for monitoring human motions and electrophysiological signals.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2024-12-17 DOI: 10.1016/j.ijbiomac.2024.138900

Xiong Liu, Lizhi Chen, Ayixianguli Sufu, Fangfei Liu

{"title":"Stretchable and self-healing carboxymethyl cellulose/polyacrylic acid conductive hydrogels for monitoring human motions and electrophysiological signals.","authors":"Xiong Liu, Lizhi Chen, Ayixianguli Sufu, Fangfei Liu","doi":"10.1016/j.ijbiomac.2024.138900","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2024.138900","url":null,"abstract":"Stretchable conductive hydrogels have attracted great attention in flexible electronics. Nevertheless, conductive hydrogels would suffer from an inevitable damage during use, significantly reducing the reliability and limiting the practicability. Herein, stretchable and self-healing conductive hydrogels are designed form carboxymethyl cellulose (CMC), polyacrylic acid (PAA), and Fe3+, which are applied for monitoring human motions and electrophysiological signals. The plentiful H-bonding and metal coordination endow the conductive hydrogels with good mechanical (fracture strain: 917 %; fracture stress: 202 kPa; toughness: 1.1 MJ m-3) and self-healing properties. After self-healing, the fracture stress is almost fully recovered, the fracture strain is restored to 72 %, and the conductivity is reestablished to 98 %. The conductive hydrogels show good fatigue resistance during cyclic tensile and compressive loading-unloading tests. Furthermore, the mechanical deformation would lead to the resistance change of the hydrogel to realize the electrical signal record. So, the hydrogel was assembled into a flexible wearable sensor that has good electrical conductivity (0.779 S m-1), fast responsiveness (response time: 300 ms; recovery time: 200 ms) and high sensitivity (gauge factor (GF) = 7.99, 400-650 %). This work demonstrates a simple and efficient strategy for developing stretchable and self-healing conductive hydrogels in healthcare monitoring and flexible electronics.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138900"},"PeriodicalIF":7.7,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Amidoxime-functionalized chitosan dual-network hydrogel: Enhanced uranium-water separation capacity.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2024-12-17 DOI: 10.1016/j.ijbiomac.2024.138867

Nijuan Liu, Duoqiang Wang, Nana Wang, Fupeng Jin, Yuanzhuo Li, Ruijuan Wang, Hongping Zhang, Hao Liang, Ruibin Guo, Zunli Mo

{"title":"An Amidoxime-functionalized chitosan dual-network hydrogel: Enhanced uranium-water separation capacity.","authors":"Nijuan Liu, Duoqiang Wang, Nana Wang, Fupeng Jin, Yuanzhuo Li, Ruijuan Wang, Hongping Zhang, Hao Liang, Ruibin Guo, Zunli Mo","doi":"10.1016/j.ijbiomac.2024.138867","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2024.138867","url":null,"abstract":"The source and after treatment of uranium, a key aspect of its use as a nuclear fuel, had been a topic of intense debate among developers. Therefore, a novel antimicrobial amidoxime-functionalized chitosan/polyacrylamide dual network hydrogel (CP-AO) had been developed utilizing a straightforward methodology. The results demonstrated excellent adsorption capacity and selectivity for uranium extraction under varying conditions, the U(VI) removal was above 94 % when pH was 4. Batch adsorption experiments revealed that CP-AO attained a maximum uranium adsorption capacity of 886.73 mg/g at 298 K, which was higher than most reported adsorbents. The kinetic and thermodynamic studies presented that adsorption process for CP-AO conformed to spontaneous monolayer chem-adsorption, and it can reach equilibrium quickly within 120 min. In addition, the adsorption mechanism revealed that the chemical-interaction between CP-AO hydrogel and U(VI) was attributed to -OH, -NH2 and amidoxime group. Notably, the hydrogel showed optimistic anti-biosludge performance against three common bacteria (E. coli, S. aureus and B. subtilis) owing to effects of chitosan. CP-AO also especially was susceptible to be recycled, its adsorption capacity was 2.8 mg/g and 38.67 mg/g in simulated and actual seawater, respectively. Hence, this work provides a promising material for the extraction of uranium resources and new insights.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138867"},"PeriodicalIF":7.7,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the effect of sodium alginate, hydroxyethyl cellulose, aspartame, and poly(ethylene oxide)-b-poly(propylene oxide) copolymer on the in-vitro corrosion of AZ31 Mg alloy in simulated body fluid. 评估海藻酸钠、羟乙基纤维素、阿斯巴甜和聚（环氧乙烷）-b-聚（环氧丙烷）共聚物对模拟体液中 AZ31 Mg 合金体外腐蚀的影响。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2024-12-16 DOI: 10.1016/j.ijbiomac.2024.138749

Abdulrahman A Aleid, Moses M Solomon, Peace S Umoren, Saviour A Umoren

{"title":"Evaluation of the effect of sodium alginate, hydroxyethyl cellulose, aspartame, and poly(ethylene oxide)-b-poly(propylene oxide) copolymer on the in-vitro corrosion of AZ31 Mg alloy in simulated body fluid.","authors":"Abdulrahman A Aleid, Moses M Solomon, Peace S Umoren, Saviour A Umoren","doi":"10.1016/j.ijbiomac.2024.138749","DOIUrl":"10.1016/j.ijbiomac.2024.138749","url":null,"abstract":"Research on Mg-based implants has increased recently because of their compatibility and biodegradability. Despite this promise, challenges related to high corrosion rates hampered wide-scale deployment. This paper explores the inhibiting properties of biomacromolecules, sodium alginate (ALG), hydroxyethyl cellulose (HEC), aspartame (ASP), and poly(ethylene oxide)-b-poly(propylene oxide) copolymer (PEO-b-PPO) on AZ31 Mg alloy in simulated body fluid at 37 °C. Results revealed that PEO-b-PPO accelerated, ALG insignificantly inhibited, while ASP and HEC showed moderate inhibition. At 2000 ppm, ASP and HEC offered 54 % and 53 % protection after 48 h and over 65 % if blended. Mechanistic insights were gained via XPS, FTIR, and distribution of relaxation times (DRT) analysis. Three corrosion mechanisms, Cl- transport, charge transfer, and ion transport across inherent MgO lattice are revealed by DRT and occurred at f = 5 Hz, f = 21 Hz and 832 Hz, and f = 100,000 Hz. Inhibitors' presence prolonged the relaxation time or changed the frequency of occurrence. Carbonates (Mg, Ca), hydroxides (Mg), and phosphates are the main corrosion products. Adsorbed ASP and HEC molecules are mixed with these products to protect the alloy. These findings offer a better understanding of the underlying mechanisms that could facilitate the development of target-oriented corrosion inhibitors for Mg.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138749"},"PeriodicalIF":7.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new strategy for enhancing S-Adenosyl-L-Methionine (SAMe) oral bioavailability: Preparation of SAMe loaded inulin nanoparticles for colon targeting with in vivo validation.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2024-12-16 DOI: 10.1016/j.ijbiomac.2024.138818

Ahmet Doğan Ergin, Zerrin Sezgin Bayindir, Mehmet Gümüştaş, Arif Tanju Özçelikay, Nilufer Yüksel

{"title":"A new strategy for enhancing S-Adenosyl-L-Methionine (SAMe) oral bioavailability: Preparation of SAMe loaded inulin nanoparticles for colon targeting with in vivo validation.","authors":"Ahmet Doğan Ergin, Zerrin Sezgin Bayindir, Mehmet Gümüştaş, Arif Tanju Özçelikay, Nilufer Yüksel","doi":"10.1016/j.ijbiomac.2024.138818","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2024.138818","url":null,"abstract":"S-Adenosylmethionine (SAMe) is a crucial endogenous molecule in vital biochemical processes such as DNA, RNA, and protein methylation. It has been found beneficial in the treatment of liver disease, osteoarthritis, and particularly depression. However, SAMe's therapeutic potential is limited by low bioavailability due to poor permeability and extensive liver metabolism. This study sought to improve SAMe's bioavailability by encapsulating it in inulin nanoparticles, utilizing a colon-targeted delivery system. Inulin, a prebiotic that promotes gut health by encouraging beneficial gut bacteria, is an ideal carrier for colon-specific drug delivery. Inulin nanoparticles were prepared using the desolvation method, incorporating sodium lauryl sulfate (SLS) for ion pairing with SAMe. The nanoparticles were spray-coated onto microcrystalline cellulose inert microspheres in a fluidized bed with Eudragit L30D-55 for colon-targeted release (Nanoparticle-In-Microparticles, NIMs). Pharmacokinetic studies in rats showed that encapsulating SAMe in inulin nanoparticles resulted in a significant three-fold increase in bioavailability compared to its pure form. This enhancement highlights the potential of inulin nanoparticles as an effective delivery system for SAMe, particularly in colon-targeted therapies.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138818"},"PeriodicalIF":7.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermostable conformational transition unfavorable to the foaming stability of ovalbumin: Emphasizing structure and function relationship.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2024-12-16 DOI: 10.1016/j.ijbiomac.2024.138861

Zuyue Li, Jiaojiao Chen, Mahmoud Abou-Elsoud, Long Sheng, Dong Uk Ahn, Dewei Shu, Meiyu Liu, Xi Huang

{"title":"Thermostable conformational transition unfavorable to the foaming stability of ovalbumin: Emphasizing structure and function relationship.","authors":"Zuyue Li, Jiaojiao Chen, Mahmoud Abou-Elsoud, Long Sheng, Dong Uk Ahn, Dewei Shu, Meiyu Liu, Xi Huang","doi":"10.1016/j.ijbiomac.2024.138861","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2024.138861","url":null,"abstract":"Storage of shell eggs converts natural ovalbumin (N-OVA) into its more thermostable forms (S-OVA). This conversion may be associated with deterioration in the foaming properties of the stored shell egg. Thus, the foaming behavior of N-OVA and S-OVA, especially their performance at different pH conditions, was conducted. Compared with N-OVA, S-OVA improved foaming ability by 29.04 % at pH 3.0 and exhibited rough foam. Regarding foaming stability, the conversion of N-OVA to S-OVA had a pronounced reduction effect, with foaming stability significantly decreasing by 28.48 %-100.00 % in pH 3.0-9.0. The spectroscopic analysis revealed that the alteration in the foaming properties of OVA was fundamentally attributed to its conformational change. Thermostable conformational transition provided S-OVA with smaller particle sizes, more flexible conformations, higher surface charge, and higher surface hydrophobicity. S-OVA at pH 3.0 showed a higher surface activity, indicating superior foaming ability. Moreover, N-OVA and S-OVA formed stiff and solid-like interfaces. Notably, N-OVA exhibited higher dilatational and elastic modulus, indicating a more compact and stable adsorption layer at air-water interface. Overall, thermostable conformational transition improved the interfacial activity of OVA and enhanced its foaming ability; however, overactive proteins were detrimental to the stabilization of its interfacial films.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138861"},"PeriodicalIF":7.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of delignification on shrinking and swelling of poplar wood assessed using digital image correlation technique.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2024-12-16 DOI: 10.1016/j.ijbiomac.2024.138851

Rui Li, Fengze Sun, Wendi Wang, Jun Tang, Hui Peng, Zhu Li, Jiali Jiang, Tianyi Zhan, Liping Cai, Jianxiong Lyu

{"title":"Effect of delignification on shrinking and swelling of poplar wood assessed using digital image correlation technique.","authors":"Rui Li, Fengze Sun, Wendi Wang, Jun Tang, Hui Peng, Zhu Li, Jiali Jiang, Tianyi Zhan, Liping Cai, Jianxiong Lyu","doi":"10.1016/j.ijbiomac.2024.138851","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2024.138851","url":null,"abstract":"This study investigates lignin's influence on the hygroscopic behavior of poplar wood. Delignification was achieved using an acidic NaClO2 solution, and digital image correlation (DIC) was employed to measure strain distribution during shrinking and swelling across relative humidity (RH) ranging of 0 % to 97 %. Results showed that lignin removal increased equilibrium moisture content (EMC) by up to 3.6 % in samples with 27 % lignin reduction. Strain analysis revealed significant radial strain differences between earlywood and latewood, with tangential strain suppressed by wood rays. Increased porosity and cellulose slippage were observed following lignin removal, and samples with the highest lignin removal rate exhibited reduction exhibited over 58 % greater εxx and over 43 % greater εyy compared to untreated wood. These effects were most pronounced in latewood and regions distant from wood rays, where stress concentrations occurred. Delignification-induced cell wall thinning amplified the wood rays' inhibitory effect on anisotropic deformation during shrinking，enhancing the contrast between isotropic deformation in latewood and anisotropic deformation in earlywood during swelling. These findings provide insights into lignin's role in wood-water interactions, supporting the optimization of wood modification techniques.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138851"},"PeriodicalIF":7.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrophilic magnetic chitosan/gelatin hydrogel with enhanced fuel dehydration characteristics: Modeling, kinetic, isotherm and thermodynamic study.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2024-12-16 DOI: 10.1016/j.ijbiomac.2024.138812

Hadis Mehdimoghadam, Hassan Alijani, Nahid Pourreza

{"title":"Hydrophilic magnetic chitosan/gelatin hydrogel with enhanced fuel dehydration characteristics: Modeling, kinetic, isotherm and thermodynamic study.","authors":"Hadis Mehdimoghadam, Hassan Alijani, Nahid Pourreza","doi":"10.1016/j.ijbiomac.2024.138812","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2024.138812","url":null,"abstract":"In this research, a nanocomposite of Fe3O4/chitosan/gelatin was prepared and used as a magnetic recyclable dewatering agent to improve the quality of fuel. Prepared materials were characterized by XRD, FT-IR, VSM, BET and FESEM techniques. Effective factors on water uptake i.e., initial water content, time, percentage of Fe3O4 and adsorbent dosage were optimized with Box-Behnken design and results showed that all parameters are significant. The performances of three magnetic composites including crosslinked chitosan, functionalized chitosan and chitosan/gelatin showed that magnetic chitosan/gelatin with 13 % of Fe3O4 content has a removal percentage of 99.2-97.3 % besides the efficiencies were 35.8-43.8 % and 79.5-89 % using crosslinked chitosan, functionalized chitosan as adsorbents. Results from the kinetic study showed that pseudo - second-order model can better describe water uptake moreover, the adsorption process followed the Langmuir isotherm model. Magnetic chitosan/gelatin composite shows a maximum water removal efficiency of 97.3 % at an initial water concentration of 2500 mgL-1 after 40 min. The thermodynamic study showed that adsorption is a spontaneous process with higher feasibility at higher temperatures. Moreover, the adsorbent shows a good efficiency of 93.7 % after 6 recycling. These results confirmed good performances of the prepared hydrogel in dehydration to improve the quality of fuel.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138812"},"PeriodicalIF":7.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of bioprintable modified agar-based hydrogels with antimicrobial properties.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2024-12-16 DOI: 10.1016/j.ijbiomac.2024.138707

Edyta Piłat, Przemysław Gnatowski, Agnieszka Kurdyn, Hubert Cieśliński, Ewa Augustin, Justyna Kucińska-Lipka

{"title":"Investigation of bioprintable modified agar-based hydrogels with antimicrobial properties.","authors":"Edyta Piłat, Przemysław Gnatowski, Agnieszka Kurdyn, Hubert Cieśliński, Ewa Augustin, Justyna Kucińska-Lipka","doi":"10.1016/j.ijbiomac.2024.138707","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2024.138707","url":null,"abstract":"Due to the numerous dangers arising from excessive use of antibiotics in treatments, researchers have been searching for natural alternatives to conventional antibiotics. Despite the popularity of plant extracts, essential oils, and their derivatives in herbal medicine, their applications in novel therapies are rather limited. This paper tries to open a new possibility for infection treatments by assessing the suitability of antimicrobial hydrogels as bioinks. Antimicrobial activity against S. epidermidis, P. aeruginosa, S. aureus, E. coli of selected extracts and geraniol were investigated. Suitable agent was incorporated into agar-based hydrogel. Physicochemical properties of the obtained compositions were analyzed, including determination of swelling kinetics and key polymer network parameters, contact angle measurements, FTIR spectra analysis, biocompatibility assessment, antimicrobial tests and bioprintability studies. Results confirmed geraniol's superior antimicrobial activity in pure form and in hydrogels. The obtained materials showed high swelling capacity, satisfying extrusion processability, shape fidelity, and great biocompatibility in their unmodified state. Nevertheless, modification with geraniol caused a significant decrease of cell viability, which limits their usage as bioinks in current form, due to the cytotoxic effect on cells. To improve cells interactions, studies on materials with geraniol and other agents with similar mechanism should be conducted in the future.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138707"},"PeriodicalIF":7.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0