International Journal of Biological Macromolecules最新文献

{"title":"Dendrobium nobile Lindl. Polysaccharides ameliorate the inflammatory microenvironment in the retina of diabetic rats: a multi-omics study of the gut-blood-retina axis","authors":"Rui Wang ,&nbsp;Yege Bi ,&nbsp;Yaqi Xie ,&nbsp;Xingwang Chen ,&nbsp;Hong Li ,&nbsp;Xiaomei Nie ,&nbsp;Jia Meng ,&nbsp;Dan Liu ,&nbsp;Bing Xie ,&nbsp;Gang Su ,&nbsp;Hongsong Yu ,&nbsp;Shanjun Cai","doi":"10.1016/j.ijbiomac.2025.144732","DOIUrl":"10.1016/j.ijbiomac.2025.144732","url":null,"abstract":"<div><div>The global epidemic of type 2 diabetes (T2D) and its complications threaten human health and lives. <em>Dendrobium nobile Lindl.</em>, a traditional Chinese medicinal herb, demonstrates anti-hyperglycemic and anti-hyperlipidemic effects. However, its protective role and mechanisms against diabetes-induced retinopathy remain unclear. This study aimed to investigate the impact of <em>Dendrobium nobile Lindl.</em> Polysaccharides (DNP) on the gut microbiota-metabolite-retinal inflammatory microenvironment in T2D rats. The results demonstrated that DNP could significantly ameliorate hyperglycemia, restore gut microbiota, and improve related microbial metabolites. Interestingly, DNP restored the damaged gut barrier and improved the metabolic profiles of circulating amino and organic acids. Specifically, DNP decreased the <em>Firmicutes</em>/<em>Bacteroidota</em> (F/B) ratio, restored gut morphology and the expression of ZO-1 and claudin-1, reduced serum lipopolysaccharides (LPS) levels, decreased gut and circulating branched-chain amino acids (BCAA) metabolism, increased gut and circulating hippurate metabolism, inhibited the TLR4/NF-κB signaling pathway, and ultimately ameliorated the inflammatory microenvironment of the retina. This comprehensive multi-omics study provides the first systematic evaluation of the therapeutic effects of DNP on T2D and its associated retinal inflammatory microenvironment, proposing the “gut-blood-retina” axis as a key mechanistic pathway. Consequently, DNP treatment emerges as a promising preventive or therapeutic strategy for mitigating these pathophysiological processes.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"316 ","pages":"Article 144732"},"PeriodicalIF":7.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Starch and polyacrylic acid doped tin ferrite nanocubes for catalytic, water oxidation, and antimicrobial activities inhibiting DNA gyrase with molecular docking.","authors":"Aiman Azam, Muhammad Ikram, Ali Haider, Anum Shahzadi, Sawaira Moeen, Anwar Ul-Hamid, Hameed Ullah, Ghazanfar Nazir, Muhammad Nisar, Hamdy Khamees Thabet, Ghafar Ali","doi":"10.1016/j.ijbiomac.2025.144657","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.144657","url":null,"abstract":"<p><p>The textile sector poses global pollution through the discharge of organic dyes and antibiotic-resistant pathogens present in the environment have a significant impact on the quality of water resources. The present work demonstrates different concentrations (2 and 4 wt%) of starch (St) and a fixed amount of polyacrylic acid (PAA) doped tin ferrite (SnFe₂O₄) nanocubes (NCs) prepared by co-precipitation route. The proposed approach has the potential to degrade rhodamine B (RhB) dye, oxygen evolution reaction (OER) activity, and resist the growth of Gram-negative multiple drug resistant (MDR) Escherichia coli (E. coli), contributing to environmental remediation. XRD showed the multiple phases of SnFe₂O₄ and crystallite size significantly increased from 35.79 to 42.09 nm, with the addition of dopants. TEM images revealed the cube-like structural morphology of SnFe₂O₄ and doped samples exhibited the agglomerated NCs. The catalytic performance of 4 % St/PAA-SnFe₂O₄ NCs towards Rhodamine B (RhB) was 73.33 % in a neutral medium. The better OER performance of 4 % St/PAA-SnFe₂O₄ is attributed to lower overpotential, Tafel slope, and charge transfer resistance. Moreover, the highly doped sample highlighted strong bactericidal effectiveness for resistant Escherichia coli (E. coli) by showing a 6.45 ± 0.02 mm inhibition zone.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"144657"},"PeriodicalIF":7.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro and in vivo efficacy evaluation of new self-assembling curcumin loaded nanohyaluronan-glycerosomes on wound restoring in health and diabetic rats","authors":"Francisco José Gómez García ,&nbsp;Antonio Ramírez Andreo ,&nbsp;Maria Manconi ,&nbsp;María Letizia Manca ,&nbsp;Pietro Matricardi ,&nbsp;Chiara di Meo ,&nbsp;Xavier Fernàndez-Busquets ,&nbsp;Francisco Martínez Díaz ,&nbsp;Diego Salmerón ,&nbsp;Pía López Jornet","doi":"10.1016/j.ijbiomac.2025.144699","DOIUrl":"10.1016/j.ijbiomac.2025.144699","url":null,"abstract":"<div><div>In this study the wound healing efficacy of new self-assembling curcumin loaded nanohyaluronan-glycerosomes has been tested in healthy and diabetic rats. Curcumin was loaded in nanohyaluronan-liposomes and -glycerosomes, special vesicles obtained mixing curcumin, hyaluronan nanohydrogel and soy lecithin. Curcumin loaded liposomes and glycerosomes were also prepared, characterized and tested as references. The physico-chemical (size and size distribution, surface charge and morphology), and technological (entrapment efficiency, stability over time and skin delivery) characteristics and biological performances (safety, ability to protect in vitro cells from oxidative damage) of prepared formulations were measured. Finally, they were daily applied to skin wounds of healthy or diabetic rats. The animal skin was excided and analysed at days 3, 7 and 14. The macroscopic observation underlined the higher ability of curcumin loaded nanohyaluronan-glycerosomes to improve wound healing in diabetic rats, already on day 3 up to day 14 (<em>p</em> &lt; 0.05). Histopathological analysis confirmed an accelerated re-epithelization in healthy rats, while increased angiogenesis in diabetic ones. The superior therapeutic efficacy of curcumin loaded nanohyaluronan-glycerosomes compared to other formulations can be related to their enhanced ability to deliver higher curcumin concentrations at the wound site due to a synergistic effect of glycerol, hyaluronan nanohydrogel and lecithin.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"315 ","pages":"Article 144699"},"PeriodicalIF":7.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on extraction and purification, structural characteristics, pharmacological activities, structure-activity relationships, and applications of Chrysanthemum indicum L. polysaccharides: A review","authors":"Xing-yu Wang,&nbsp;Ai-qi Yu,&nbsp;Zhao-jiong Zhang,&nbsp;Jing-yuan Wang,&nbsp;Hai-zheng Bi,&nbsp;Meng Wang","doi":"10.1016/j.ijbiomac.2025.144689","DOIUrl":"10.1016/j.ijbiomac.2025.144689","url":null,"abstract":"<div><div><em>Chrysanthemum indicum</em> L<em>.</em> (<em>C. indicum</em>) is a broadly dispersed natural medicinal plant belonging to the genus <em>Chrysanthemum</em> within the family Asteraceae. As an herb medicine and a novel food resource, it possesses multifaceted values such as ornamental, edible and even medicinal. The polysaccharides in <em>C. indicum</em> constitute a significant active component, exhibiting gratifying and remarkable pharmacological activities, including antiviral, alleviating liver damage, anti-glycation, antioxidant, and promoting wound healing effects. The article summarizes the research progress of the extraction and purification, structural characteristics, pharmacological activities, structural modifications, structure-activity relationships, and applications of <em>C. indicum</em> polysaccharides for the first time. Moreover, the current situation of related patent research is expounded, and the potential mechanism behind the pharmacological activities of <em>C. indicum</em> polysaccharides is elucidated. Meanwhile, the current limitations in the research on <em>C. indicum</em> polysaccharides have been analyzed, and future research directions have been proposed. Aiming to provide insights and perspectives for the in-depth exploration and study of <em>C. indicum</em> polysaccharides.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"315 ","pages":"Article 144689"},"PeriodicalIF":7.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial activity of environmental Bacillus spp. and Peribacillus spp. isolates linked to surfactin, fengycin, bacillibactin and lantibiotics","authors":"Julia Manetsberger ,&nbsp;Natacha Caballero Gómez ,&nbsp;Nabil Benomar ,&nbsp;Graham Christie ,&nbsp;Hikmate Abriouel","doi":"10.1016/j.ijbiomac.2025.144644","DOIUrl":"10.1016/j.ijbiomac.2025.144644","url":null,"abstract":"<div><div><em>Bacillus</em> and closely related species are amongst the most exploited organisms for the development of novel bioactive formulations in sustainable agriculture. These bacteria produce a wide arsenal of bioactive compounds, such as antimicrobial peptides which are gaining increasing attention. Using an <em>in-silico</em> approach we characterised the whole genomes of five environmental isolates belonging to the <em>Bacillus subtilis</em>, <em>Peribacillus simplex</em> and <em>Bacillus cereus</em> clade with antimicrobial potential. We showed that the isolates contain genomic sequences for a wide range of secondary metabolites, including lipopeptides surfactin, fengycin, the siderophore bacillibactin or several promising lantipeptides. <em>Ex situ</em> production of antimicrobial substances was confirmed <em>in vitro</em>, detecting synergistic effects between isolates from the same origin. The strains furthermore exhibited a strong capacity of biofilm formation <em>in silico</em> and <em>in vitro</em>, although no synergy occurred. Regarding safety properties, all strains were found to harbour virulence and virulence-associated factors including antibiotic resistance genes. In summary, this study provides valuable insights into the genetic make-up and variations of spore-formers derived from olive orchards, which can be useful for the development of antimicrobial agents in sustainable agriculture.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"316 ","pages":"Article 144644"},"PeriodicalIF":7.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A durable biocatalyst constructed by immobilization of recombinant laccase-like multicopper oxidase from Bacillus mojavensis onto hazelnut shell hydrochar: Its characterization and potential for use in the degradation of sulfamethoxazole and diclofenac","authors":"Serpil Könen Adıgüzel ,&nbsp;Sevde Üstün Odabaşı ,&nbsp;Erdal Yabalak ,&nbsp;Nisa Gül Kaya ,&nbsp;Birgül Mazmancı ,&nbsp;Ali Osman Adıgüzel","doi":"10.1016/j.ijbiomac.2025.144640","DOIUrl":"10.1016/j.ijbiomac.2025.144640","url":null,"abstract":"<div><div>The present study investigates the immobilization of recombinant LMCO from <em>Bacillus mojavensis</em> TH308 (BmLMCO) on hazelnut shell hydrochar (HSH) and the use of the thus constructed biocatalyst (HSH-BmLMCO) to degrade sulfamethoxazole and diclofenac. Immobilization of BmLMCO with 120 U/mg protein-specific activity was achieved with 77.3 ± 2.7 % yield and 39.4 ± 1.3 % activity loss under the optimal conditions (pH 6, 24 h, and 10 °C). FTIR analyses indicated that the hydroxyl, carbonyl, and carboxyl groups played a role in adsorption, while FESEM analyses showed that the enzyme clustered in the pores of FSH. Similar to the free enzyme, HSH-BmLMCO exhibited maximum activity at 80 °C and pH 8. However, immobilization enhanced the thermal stability. The half-life of HSH-BmLMCO at 30, 40, 50, 60, and 70 °C was calculated to be about 648, 612, 496, 418, and 359 min, respectively. The addition of Cu²⁺ to the reaction mixture caused a 39.52 % enhancement in the activity of HSH-BmLMCO. Tween 20, Triton X-100, and SDS increased the laccase activity by 25.8 %, 26.4 %, and 7.0 %, respectively, while PMSF and β-mercaptoethanol decreased the oxidative activity of the biocatalyst by about 35 %. The Michaelis constant (<em>K</em>_<em>m</em>) values of the HSH-BmLMCO against 2,6-DMP, SGZ, and ABTS were 1.18, 0.52, and 0.21 mM, respectively. HSH-BmLMCO retained 53.4 ± 3.5 % and 91.6 ± 1.5 % of its activity when stored at 4 °C for 48 days. Its residual activity after 10 consecutive catalytic cycles was 91.6 ± 1.5 %. The biocatalyst degraded sulfamethoxazole and diclofenac pharmaceuticals by about 85 % and 80 % within 30 min, respectively. Furthermore, no toxic effects of the degradation products on the aquatic model organism <em>Daphnia magna</em> were observed. So, to sum up, the study provides an enormous biocatalyst for practical bioremediation applications. To our knowledge, this is the first report describing the biocatalyst constructed with <em>B. mojavensis</em> LMCO and hazelnut shell hydrochars and demonstrating its potential remediation application.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"315 ","pages":"Article 144640"},"PeriodicalIF":7.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yunnan Baiyao-enhanced cellulose nanofiber composite hydrogel wearable patch for transdermal drug delivery and anti-freezing applications","authors":"Xing Gao ,&nbsp;Hongchao Zhang ,&nbsp;Chufan Yan ,&nbsp;Jie Wu ,&nbsp;Yutong Wang ,&nbsp;Minghao Jiang ,&nbsp;Yanan Wang","doi":"10.1016/j.ijbiomac.2025.144684","DOIUrl":"10.1016/j.ijbiomac.2025.144684","url":null,"abstract":"<div><div>Traditional kinesiology tape has limitations such as poor stretchability, skin irritation, and lack of drug-delivery action. Hydrogels, with their unique physicochemical performance, offer significant potential for developing drug-delivering wearable patches. Yunnan Baiyao (YNBY) and Borneol (BP) are traditional Chinese medicines known for their anti-inflammatory and detoxification effects. In this study, a novel traditional Chinese medicine-loaded composite hydrogel (PPCB-YBx) was prepared by incorporating YNBY and BP into cellulose nanofibers (CNFs) composite biopolymer network. The results showed that the PPCB-YB4 hydrogel exhibited excellent stretchability (~1876 % elongation at break), non-irritating skin adhesion, and sustained drug release behavior (88 % released over 72 h) through a non-Fickian diffusion mechanism. Moreover, it showed good biocompatibility, antibacterial activity, gas permeability, and transdermal properties. The PPCB-YB4 hydrogel also exhibited unique anti-freezing (−27.7 °C) and anti-swelling characteristics (swelling ratio of ~4.5 %) and enhanced water retention, making it suitable for use in extreme environments. These results indicate that the PPCB-YBx hydrogel is a promising drug-releasing wearable patch with potential application prospects in healthcare and sports rehabilitation.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"315 ","pages":"Article 144684"},"PeriodicalIF":7.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A floating adsorbent of poly(acrylic acid) encapsulating a waste polystyrene and lignocellulose fiber composite for the removal of cationic dyes from water","authors":"Mallika Keawbanjong,&nbsp;Piyawan Kongseng,&nbsp;Sirinya Chantarak,&nbsp;Watchanida Chinpa","doi":"10.1016/j.ijbiomac.2025.144671","DOIUrl":"10.1016/j.ijbiomac.2025.144671","url":null,"abstract":"<div><div>A floating adsorbent was fabricated of poly(acrylic acid) (PAA) hydrogel encapsulating a composite of oil palm empty fruit bunch microfiber (EFBM) and waste polystyrene (PS). The porous composite was prepared from PS and EFBM in a phase separation process. The interaction between hydrophobic PS and hydrophilic EFBM was confirmed by scanning electron microscopy. The loading of 10 wt% EFBM in PS increased elongation at break by 61.5 %, toughness by 93.3 % and water absorption by 262 % when the composite was compared with neat PS. The good water uptake of the composite due to EFBM improved the adhesion between PAA and the porous composite. An adsorbent dosage of 5 g L⁻¹ in an initial methylene blue (MB) concentration of 50 mg L⁻¹ removed 97 % of MB from an aqueous solution. The adsorption of MB followed the Langmuir isotherm model, giving a maximum adsorption capacity of 277.8 mg g⁻¹ at 28 °C. A thermodynamics study revealed spontaneous and exothermic adsorption. The floating adsorbent selectively removed cationic dyes but repulsed anionic dyes. The simple separation of the adsorbent from solution, and its stability, enabled multiple adsorption cycles. This work shows the potential of using lignocellulosic and plastic wastes as low-cost raw materials for the fabrication of an effective floating adsorbent for the removal of cationic dyes in water.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"316 ","pages":"Article 144671"},"PeriodicalIF":7.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital light processing-printed personalized gelatin Methacryloyl/silk fibroin Methacryloyl hydrogel microneedles loaded with platelet-rich proteins for accelerated wound healing","authors":"Bo Li ,&nbsp;Ting Wu ,&nbsp;Bo Liu ,&nbsp;Hanif Ullah ,&nbsp;Shuo Shi ,&nbsp;Ying Hao ,&nbsp;Ka Li ,&nbsp;Yuwen Chen","doi":"10.1016/j.ijbiomac.2025.144693","DOIUrl":"10.1016/j.ijbiomac.2025.144693","url":null,"abstract":"<div><div>The hydrogel microneedles (HMNs) with good biocompatibility enables the efficient and painless delivery of bioactive substances to deeper tissue, promoting effective wound healing. However, due to the inherent variability in size, shape, and depth of wounds during practical application, for HMNs, customization is essential for optimal alignment with individual wounds to expedite the healing process. Here, we developed a personalized gelatin methacrylate/methacrylated silk fibroin (GelMA/SFMA) HMNs loaded with platelet-rich proteins (GSPMNs) to accelerate wound healing. By integrating 3D scanning with digital light processing (DLP) static-based printing technology, we fabricated customized HMNs patches tailored to the size, shape, and depth of the wound. The GSPMNs exhibited appropriate mechanical properties, puncture resistance, and sustained-release capability of growth factors. The cell experiments demonstrated favorable biocompatibility of GSPMNs along with its ability to promote cellular growth, proliferation, and migration. Furthermore, in vivo studies revealed that the GSPMNs patches significantly accelerated wound healing by facilitating reepithelialization and collagen deposition. These findings would provide potential novel options for bedside printing of complex personalized wound patches.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"316 ","pages":"Article 144693"},"PeriodicalIF":7.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium alginate-enhanced MXene multifunctional hydrogel: Dual temperature-strain response and recyclability.","authors":"Junzheng Chen, Xue Lv, Xikun Zhang, Huiwen Jia, Yanmin Ma, Wang Xu, Xiaoning Yang, Di Fang, Shurui Yi","doi":"10.1016/j.ijbiomac.2025.144675","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.144675","url":null,"abstract":"<p><p>Conductive hydrogels are valued for their flexibility and sensitivity for flexible wearable sensors, but they typically focus on strain sensing and lack features such as fast temperature response. In addition, discarded sensors can cause environmental problems. Based on this, we developed a novel G₂B₃M₄ hydrogel using NIPAAm, AM, PDA@BN, MXene, and SA to achieve dual response to temperature and strain as well as reuse after disposal. The addition of the copolymerized hydrophilic monomer AM successfully changed the lowest critical solution temperature (LCST) of G₂B₃M₄ to approach the normal body temperature. In addition, the excellent dispersion of PDA@BN in the G₂B₃M₄ hydrogel not only improved its temperature sensitivity (TCR = -1.953 %/°C) but also resulted in a high stress (730.38 kPa), strain (6994.18 %), elasticity (49.14 kPa) and toughness (2644.17 KJ/m³). In addition, the abundant catechol groups, amino groups and carboxyl groups in G₂B₃M₄ hydrogel not only make it have good adhesion to various substrates but also can be used as a template to reduce Ag⁺ to Ag NPs to serve as a catalyst for the efficient degradation of dye wastewater. The hydrogel has good application prospects in the field of flexible sensors.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"144675"},"PeriodicalIF":7.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}