International Journal of Biological Macromolecules最新文献_第8页

Superhydrophobic cotton fabrics for efficient separation of solutions/oils of various corrosiveness and temperatures and removable "wrap-around" suction unit for oil spill adsorption. 超疏水棉织物可有效分离各种腐蚀性和温度的溶液/油，可拆卸的 "环绕式 "吸油装置可吸附溢油。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-02 DOI: 10.1016/j.ijbiomac.2025.142565

Yike Han, Shuangshuang Xia, Zongxue Yu, Zhiquan Chen, Yan Chen, Shijie Guo, Pengao Yu

{"title":"Superhydrophobic cotton fabrics for efficient separation of solutions/oils of various corrosiveness and temperatures and removable \"wrap-around\" suction unit for oil spill adsorption.","authors":"Yike Han, Shuangshuang Xia, Zongxue Yu, Zhiquan Chen, Yan Chen, Shijie Guo, Pengao Yu","doi":"10.1016/j.ijbiomac.2025.142565","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.142565","url":null,"abstract":"<p><p>In fact, in the face of efficient recovery of oil spills at sea and the increasingly serious problem of oilfield wastewater, there is no environmentally friendly, economical, simple and mature technical solution, and efficient oil-water separation technology has not yet been fully realised. In this paper, a simple strategy of loading ferric tetroxide (Fe<sub>3</sub>O<sub>4</sub>)/zirconium dioxide (ZrO<sub>2</sub>) nanoparticles on the surface of fabrics or sponges is proposed to successfully prepare superhydrophobic materials (FZ-3-PDMS-CF/PU). It showed excellent performance in the selective separation of water and heavy/light oil. Superhydrophobic fabrics exhibited ultra-high separation efficiency (99.9 %) and good permeate flux (3440 ± 68 L·m<sup>-2</sup>·h<sup>-1</sup>) for water/trichloromethane mixtures during oil removal. Meanwhile, the FZ-3-PDMS-CF showed excellent separation effect (>98 %) for all kinds of corrosive solutions/oils as well as different temperature solution/oil mixtures. The energy-saving gravity-driven separation method is used throughout the process, providing a strong competitive path for the separation of light/heavy oil-water mixtures. Notably, \"wraparound\" fabric-sponge-fabric micro-absorbent devices with double-layer protection and mobility offer options for recovering oil spills at sea.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"142565"},"PeriodicalIF":7.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Corrigendum to "Immp2l gene knockout induces granulosa cell senescence by activation of cGAS-STING pathway via TFAM-mediated mtDNA leakage"[Int. J. Biol. Macromol. 307 (2025) 142368].

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-02 DOI: 10.1016/j.ijbiomac.2025.142619

Pengge Pan, Sinan Cao, Hui Gao, Xiaoya Qu, Yan Ma, Jinyi Yang, Xiuying Pei, Yanzhou Yang

引用次数: 0

Micropolymorphism outside the peptide-binding groove of human leukocyte antigen (HLA)-C*14 modulates structural stability and shapes immune responses

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-02 DOI: 10.1016/j.ijbiomac.2025.142772

Qingyang Liu , Min Yang , Peiluan Zhong, Qinglin Wei, Huifang Jiao, Jiaqi Meng, Liurui Ding, Xiaopeng Zhu, Pengcheng Wei

{"title":"Micropolymorphism outside the peptide-binding groove of human leukocyte antigen (HLA)-C*14 modulates structural stability and shapes immune responses","authors":"Qingyang Liu , Min Yang , Peiluan Zhong, Qinglin Wei, Huifang Jiao, Jiaqi Meng, Liurui Ding, Xiaopeng Zhu, Pengcheng Wei","doi":"10.1016/j.ijbiomac.2025.142772","DOIUrl":"10.1016/j.ijbiomac.2025.142772","url":null,"abstract":"<div><div>Micropolymorphisms in human leukocyte antigen class I (HLA–I) molecules critically influence antigen presentation and immune recognition. Most studies have focused on variations within the peptide-binding groove (PBG), neglecting the potential impact of residues located outside this region. HLA-C*14:02 and HLA-C*14:03 differ only at position 21 (R21 and H21, respectively), which is situated outside the PBG, yet these two allotypes exhibit distinct clinical associations with HIV control in the context of KIR2DL2, an inhibitory killer cell immunoglobulin-like receptor that modulates natural killer (NK) cell activity. Here, we investigated the molecular mechanisms by which the R21H micropolymorphism shapes immune responses. Structural and biochemical analyses revealed that position 21 indirectly regulates the conformation of the B pocket within the PBG, significantly affecting HLA-C*14 stability and altering the composition of its peptide repertoire, while preserving core peptide motifs and recognition by KIR2DL2. Notably, the R21H variation is evolutionarily conserved across various HLA-I molecules and exhibits similar interactions with neighboring residues, suggesting a broadly conserved role in structural stability and immune regulation. These findings suggest that the stability differences between HLA-C*14 allotypes may influence their differential clinical associations, highlighting the previously underappreciated role of micropolymorphisms outside the PBG in modulating immune responses.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"309 ","pages":"Article 142772"},"PeriodicalIF":7.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A 3D bioprinted gelatin/quaternized chitosan/decellularized extracellular matrix based hybrid bionic scaffold with multifunctionality for infected full-thickness skin wound healing

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-02 DOI: 10.1016/j.ijbiomac.2025.142816

Jie Xu , Ya Su , Jiayi Yang , Hailin Ma , Huan Fang , Jingjing Zhu , Jiang Du , Yuen Yee Cheng , Yue Kang , Yiming Zhong , Bo Pan , Kedong Song

{"title":"A 3D bioprinted gelatin/quaternized chitosan/decellularized extracellular matrix based hybrid bionic scaffold with multifunctionality for infected full-thickness skin wound healing","authors":"Jie Xu , Ya Su , Jiayi Yang , Hailin Ma , Huan Fang , Jingjing Zhu , Jiang Du , Yuen Yee Cheng , Yue Kang , Yiming Zhong , Bo Pan , Kedong Song","doi":"10.1016/j.ijbiomac.2025.142816","DOIUrl":"10.1016/j.ijbiomac.2025.142816","url":null,"abstract":"<div><div>Skin wound repair, a highly integrated and overlapping process, is susceptible to infection, hyperoxia and excessive inflammation, which can delay wound healing or even lead to chronic wounds. In this study, a GQL/dGQue bilayered multifunctional scaffold, epidermis composed of gelatin (G), quaternized chitosan (Q) and lignin (L), and dermis composed of skin-derived decellularized extracellular matrix (d), gelatin and quercetin (Que), with bionic skin structure, was constructed by 3D bioprinting technology. The results showed that lignin effectively improved the mechanical properties (Young's modulus above 90 MPa) and regulated the appropriate degradation (about 84 % for 15 d) of the scaffold, as well as endowed it with good UV shielding properties. In addition, GQL/dGQue showed prominent antibacterial activity of 90.76 ± 4.94 % and 90.34 ± 4.14 % against <em>E. coli</em> and <em>S. aureus</em>, respectively, good free radical scavenging (87.22 ± 1.71 %) and significant anti-inflammatory properties. <em>In vivo</em> studies demonstrated that GQL/dGQue scaffold could effectively prevent wound infection and mitigate inflammation, thereby accelerating vascularization and regeneration of hair follicle and sebaceous gland with a remarkable wound closure of 98.29 ± 1.77 % at 21 d. Therefore, the GQL/dGQue bilayered multifunctional scaffold has a considerable potential to apply in skin tissue engineering for clinical wound repair.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"309 ","pages":"Article 142816"},"PeriodicalIF":7.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Extraction methods, structural diversity and potential biological activities of Artemisia L. polysaccharides (APs): A review 蒿多糖（APs）的提取方法、结构多样性和潜在生物活性：综述。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-02 DOI: 10.1016/j.ijbiomac.2025.142802

Adil Hussain

{"title":"Extraction methods, structural diversity and potential biological activities of Artemisia L. polysaccharides (APs): A review","authors":"Adil Hussain","doi":"10.1016/j.ijbiomac.2025.142802","DOIUrl":"10.1016/j.ijbiomac.2025.142802","url":null,"abstract":"<div><div>The extraction and structural characterization of polysaccharides are challenging in plants with overlapping distributions such as <em>Artemisia,</em> the plant genus producing antimalarial drug artemisinin discovered by the Nobel Prize 2015 winning Professor Tu You-you. The diversity in <em>Artemisia</em> polysaccharides (APs) is due to difference in extraction methods leading to different bioactivities. In spite of that, APs utilization is decelerated due to lack of a review portraying current advancements. This review delivers data on extraction, structural characterization and bioactivities of APs with emphasis on mechanisms of action and structure-function relationships. Outcomes indicated that various polysaccharides in 16 <em>Artemisia</em> species were reported and comprehensively described. The common methods for preparing APs were hot water and microwave assisted extractions with maximum yield. Maximum plant parts used to extract APs include leaves, aerial part, whole plant and seeds. The APs presented varying molecular weight, monosaccharide composition, carbohydrates, proteins, uronic acids and phenolic content with around 20 bioactivities. Data on structure-function relationships indicated that the bioactivities of APs are highly correlated with the differences in Mw and monosaccharide's type. While <em>Artemisia</em> species discussed here are the most studied species for their polysaccharides, other <em>Artemisia</em> species may offer unique polysaccharides with distinct biological properties; hence, the future research could focus on expanding the scope of species studied. Broader investigations are also needed specifically on the structure-function relationships of APs with the elucidation of impact of unknown factors on their efficacy.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"309 ","pages":"Article 142802"},"PeriodicalIF":7.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Anti-bacterial films developed by incorporating shikonin extracted from radix lithospermi and nano-ZnO into chitosan/polyvinyl alcohol for visual monitoring of shrimp freshness"[Int. J. Biol. Macromol. Volume 260, Part 2, March 2024, 129542].

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-02 DOI: 10.1016/j.ijbiomac.2025.142606

Jehangir Khan, Shah Alam, Teshale Ayano Begeno, Zhenxia Du

引用次数: 0

High–strength, solvent–resistant carboxymethyl chitosan composite rubber based on dual covalent crosslinking network and hydrogen bond network for multi–functional sensing

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-02 DOI: 10.1016/j.ijbiomac.2025.142437

Wenyu Pan , Zequan Li , Fangyan Ou , Zhichao Zhang , Changsheng Wang , Ting Xie , Chuang Ning , Riyao Cong , Xuehan Gao , Zhiyong Qin , Zengxi Wei , Qian Sun , Wei Gao , Yan Qing , Shuangliang Zhao

{"title":"High–strength, solvent–resistant carboxymethyl chitosan composite rubber based on dual covalent crosslinking network and hydrogen bond network for multi–functional sensing","authors":"Wenyu Pan , Zequan Li , Fangyan Ou , Zhichao Zhang , Changsheng Wang , Ting Xie , Chuang Ning , Riyao Cong , Xuehan Gao , Zhiyong Qin , Zengxi Wei , Qian Sun , Wei Gao , Yan Qing , Shuangliang Zhao","doi":"10.1016/j.ijbiomac.2025.142437","DOIUrl":"10.1016/j.ijbiomac.2025.142437","url":null,"abstract":"<div><div>In order to prepare natural polymer composite rubber with excellent mechanical properties, solvent resistance and electrical conductivity, and to apply it to multifunctional sensing. In this study, an environmentally friendly and effective strategy was employed to solve these problems. Carboxymethyl chitosan composite rubber was prepared by introducing the dual covalent crosslinking network into carboxy nitrile butadiene rubber via amide and radical reactions, followed by blending with carboxymethyl chitosan to introduce a hydrogen bonding network. The tensile strength of the prepared composite rubber was increased by 45 times, the crosslink density was increased by 405 times, the mechanical properties and solvent resistance were significantly improved, and the electrical conductivity was also obtained. Based on these excellent properties, carboxymethyl chitosan composite rubber can be used in strain sensors to detect human movement, and realize information encryption; it can also be used in humidity sensors to detect human respiration, environmental humidity and industrial pipeline safety. The nature polymer composite rubber prepared in this work will have great potential for application in flexible electronic devices.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"309 ","pages":"Article 142437"},"PeriodicalIF":7.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Development and characterization of starch/PVA antimicrobial active films with controlled release property by utilizing electrostatic interactions between nanocellulose and lauroyl arginate ethyl ester"[Int. J. Biol. Macromol. 261 (2024) 129415].

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-02 DOI: 10.1016/j.ijbiomac.2025.142624

Junxiao Qiao, Yiyan Dong, Chenwei Chen, Jing Xie

引用次数: 0

Near-infrared light-triggered silk fibroin hydrogels integrated with polydopamine-modified nanoparticles for enhanced wound healing and infection control

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-02 DOI: 10.1016/j.ijbiomac.2025.142814

Shaorong Yan , Zhenxin Yu , Haomin Yang , Yongqiang Yang , Jien Qin , Xiaochen Wu , Gaoyang Lin

{"title":"Near-infrared light-triggered silk fibroin hydrogels integrated with polydopamine-modified nanoparticles for enhanced wound healing and infection control","authors":"Shaorong Yan , Zhenxin Yu , Haomin Yang , Yongqiang Yang , Jien Qin , Xiaochen Wu , Gaoyang Lin","doi":"10.1016/j.ijbiomac.2025.142814","DOIUrl":"10.1016/j.ijbiomac.2025.142814","url":null,"abstract":"<div><div>This study presents the development and evaluation of a novel silk fibroin (SF)-based hydrogel composite, SiPDA/Ag-C, enhanced with polydopamine (PDA)-modified silver nanoparticles (Ag@PDA) and PDA-modified curcumin (Cur-PDA), for skin wounds treatment and infection control. Dopamine readily oxidizes and reacts with SF to form hydrogels. By <em>in-situ</em> synthesizing silver nanoparticles (Ag NPs) on the surface of PDA nanospheres, Ag@PDA achieves a dual antibacterial effect. It combines the photothermal antibacterial property of PDA with the ability of Ag NPs to disrupt bacterial membranes and DNA. Coating PDA on the surface of curcumin creates Cur-PDA nanoparticles, which not only enhance curcumin's bioavailability but also integrate curcumin's anti-inflammatory and antioxidant properties with PDA's antioxidant and photothermal antibacterial capabilities. Combining Ag@PDA and Cur-PDA into the SF hydrogel matrix results in the SiPDA/Ag-C hydrogel. The hydrogel leverages the photothermal properties of PDA to achieve non-invasive wound healing under near-infrared (NIR) light irradiation. The SiPDA/Ag-C hydrogel could significantly inhibit the growth of <em>Staphylococcus aureus</em> and <em>Escherichia coli in vitro</em> and <em>in vivo</em>, and promote wound healing by reducing inflammation, enhancing antioxidant capacity, and stimulating tissue regeneration. <em>In vivo</em> study shows that compare with the treatment of SiPDA/Ag-C hydrogel alone, the combined treatment with NIR irradiation could significantly inhibit bacterial growth and improve tissue repair. The hydrogel also exhibited excellent biocompatibility, biodegradability, and minimal cytotoxic effects, making it a promising candidate for advanced wound care and tissue engineering applications.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"309 ","pages":"Article 142814"},"PeriodicalIF":7.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STEAP proteins: Roles in disease biology and potential for therapeutic intervention

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-02 DOI: 10.1016/j.ijbiomac.2025.142797

Qiaomei Cai , Chao Jing , Xudong Wang , Xiangling Xing , Wancheng Liu

{"title":"STEAP proteins: Roles in disease biology and potential for therapeutic intervention","authors":"Qiaomei Cai , Chao Jing , Xudong Wang , Xiangling Xing , Wancheng Liu","doi":"10.1016/j.ijbiomac.2025.142797","DOIUrl":"10.1016/j.ijbiomac.2025.142797","url":null,"abstract":"<div><div>Iron and copper are essential metal ions, and maintaining their metabolic balance is critical for organismal health. The Six-Transmembrane Epithelial Antigen of the Prostate (STEAP) protein family, comprising STEAP1, STEAP2, STEAP3, and STEAP4, plays a vital role in cellular metal homeostasis. These proteins are located on the cell membrane and are characterized by six transmembrane domains. With the exception of STEAP1, the STEAP proteins function as metal oxidoreductases due to their F<sub>420</sub>H<sub>2</sub>:NADP<sup>+</sup> oxidoreductase (FNO)-like domain. However, STEAP1 contributes to metal metabolism through its heme group and interaction with other STEAP proteins. Beyond metal metabolism, STEAP proteins are involved in critical cellular processes, including the regulation of the cell cycle, proliferation, differentiation, and apoptosis. Notably, STEAP proteins are recognized as potential biomarkers and therapeutic targets in human cancers, particularly prostate cancer. This review outlines the structural features and functional roles of STEAP proteins in various diseases, including cancers, insulin resistance, non-alcoholic fatty liver disease (NAFLD), and benign prostatic hyperplasia, with a focus on their potential for therapeutic intervention.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"309 ","pages":"Article 142797"},"PeriodicalIF":7.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0