International Journal of Biological Macromolecules最新文献_第8页

The novel cathelicidin-DM antimicrobial peptide conjugated carbomer and thermosensitive chitosan hydrogel speeds up wound-healing in both non-infected and S. aureus-infected wounds. 新型抗菌肽- dm结合卡波姆和热敏壳聚糖水凝胶加速伤口愈合在非感染和金黄色葡萄球菌感染的伤口。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-02-01 Epub Date: 2024-12-10 DOI: 10.1016/j.ijbiomac.2024.138659

Guixi Wang, Yafei Huang, Yaoqiang Shi, Qinqin Han, Jinyang Zhang, Yuzhu Song, Chao Li

{"title":"The novel cathelicidin-DM antimicrobial peptide conjugated carbomer and thermosensitive chitosan hydrogel speeds up wound-healing in both non-infected and S. aureus-infected wounds.","authors":"Guixi Wang, Yafei Huang, Yaoqiang Shi, Qinqin Han, Jinyang Zhang, Yuzhu Song, Chao Li","doi":"10.1016/j.ijbiomac.2024.138659","DOIUrl":"10.1016/j.ijbiomac.2024.138659","url":null,"abstract":"The emergence of chronic wound infections and bacterial resistance presents substantial clinical challenges that impact millions worldwide. Antimicrobial peptides (AMPs), recognized for their potent antimicrobial properties, are considered promising alternatives to conventional antibiotics in light of escalating drug resistance. In previous research, we isolated an AMP named cathelicidin-DM from Duttaphrynus melanostictus, which exhibited broad-spectrum efficacy against multidrug-resistant bacteria and demonstrated wound-healing capabilities. This peptide represents a novel therapeutic option for treating infected chronic wounds. However, AMPs are susceptible to degradation when applied in the treatment of wound infections, which may compromise their effectiveness. To further advance the application of cathelicidin-DM in wound healing, we developed cathelicidin-DM-carbomer and thermosensitive cathelicidin-DM-chitosan hydrogels. Our results indicated that cathelicidin-DM interacted with both carbomer and chitosan at the molecular level, adhering to the surface of the hydrogels, which exhibit a three-dimensional network structure and favorable rheological properties. Animal experiments demonstrated that these cathelicidin-DM hydrogels exhibited hemostatic capabilities and significantly enhance the healing of both infected and non-infected full-thickness skin wounds in mice when applied as wound dressings. In summary, cathelicidin-DM carbomer and cathelicidin-DM chitosan hydrogels represent a dual-functional materials with both antimicrobial and wound-healing properties, thereby demonstrating considerable potential for clinical application.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138659"},"PeriodicalIF":7.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel strategy of dysphagia-oriented matrices bovine tendon collagen-cassava starch composite gels. 吞咽困难导向基质牛腱胶原-木薯淀粉复合凝胶的新策略。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-02-01 Epub Date: 2024-12-11 DOI: 10.1016/j.ijbiomac.2024.138691

Yuhong Lin, Zhuo Wang, Chaoxue Shi, Ling Han, Qunli Yu

{"title":"A novel strategy of dysphagia-oriented matrices bovine tendon collagen-cassava starch composite gels.","authors":"Yuhong Lin, Zhuo Wang, Chaoxue Shi, Ling Han, Qunli Yu","doi":"10.1016/j.ijbiomac.2024.138691","DOIUrl":"10.1016/j.ijbiomac.2024.138691","url":null,"abstract":"Dysphagia foods are designed for individuals with swallowing difficulties to consume safely. Texture-modified diets have become essential in dysphagia management. This study aimed to assess the safety and effectiveness of bovine tendon collagen (BTC) as a texture modifier to alter the starch gel network through a synergistic effect with cassava starch (CS), enhancing its application in dysphagia foods. The results indicated that BTC addition initially reduced gel water retention then increased, with a minimum observed at 2 % BTC. However, all gels demonstrated excellent WHC. The viscoelasticity, hardness, adhesion, gumminess, and thermal stability of composite gels improved with rising BTC concentrations. Secondary structure analysis revealed BTC altered the ordered structures of CS, with hydrogen bonds playing a key role. The microstructure showed that BTC disrupted and attached to the gel network, forming a more compact structure. Additionally, BTC inhibited CS digestion, increasing resistant starch content and decreasing rapidly digestible starch content. Furthermore, International Dysphagia Diet Standardization Initiative tests indicated that 2 % BTC gels could be categorized as level 4 (pureed or extremely thick), while gels with 4-6 % BTC could be classified as level 5 (minced and moist). These findings highlight the potential of BTC-CS composite gels for innovative dysphagia food development.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138691"},"PeriodicalIF":7.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper peroxide-loaded lignin-based non-isocyanate polyurethane foam for wound repair applications. 过氧化铜负载木质素基非异氰酸酯聚氨酯泡沫伤口修复应用。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-02-01 Epub Date: 2024-12-16 DOI: 10.1016/j.ijbiomac.2024.138733

Mengqiu Quan, Jingrui Li, Minghui Cui, Genzheng Sha, Yuqing Wang, Bozhen Wu, Jin Zhu, Jing Chen

{"title":"Copper peroxide-loaded lignin-based non-isocyanate polyurethane foam for wound repair applications.","authors":"Mengqiu Quan, Jingrui Li, Minghui Cui, Genzheng Sha, Yuqing Wang, Bozhen Wu, Jin Zhu, Jing Chen","doi":"10.1016/j.ijbiomac.2024.138733","DOIUrl":"10.1016/j.ijbiomac.2024.138733","url":null,"abstract":"Wound healing is a complex process and the mechanism of the tissue repair process involves many complex steps: inflammation, proliferation, and maturation. Wounds can be divided into two main categories: acute and chronic wounds. Non-healing wounds usually follow a bacterial infection. Many types of materials on the market have been developed for use as wound dressings. Polyurethane foam for wound dressings has many advantages over other materials, especially for moderate wounds and drainage. In this study, lignin-based non-isocyanate polyurethane foams were prepared using a green route by oxygen alkylation modification of enzymatically dissolved lignin, cyclic carbonation and polymerization with diamines to add a blowing agent. By loading CuO2 on the surface of the prepared lignin-based non-isocyanate polyurethane foam, a pH-responsive wound dressing, named lignin-based non-isocyanate polyurethane/copper peroxide composite foam (named NIPU foam-CuO2), was prepared, which can specifically release the strong oxidizing OH under acidic conditions. The composite foam can effectively kill the bacteria in the wound. The test results proved that the composite foam has excellent mechanical properties, thermal stability, and biocompatibility. NIPU-foam-CuO2 100 mM inhibited two types of bacteria, Escherichia coli, and Staphylococcus aureus, by up to 98 % and 95 % within 8 h, respectively. It also shows excellent performance in promoting wound healing in organism experiments as well as in the subsequent histological staining. The lignin-based NIPU foams of this work exhibit remarkable innovation and unique properties in terms of environmental friendliness, performance and antimicrobial resistance. At the same time, we also mention potential problems such as drug resistance in the long-term use of NIPU-CuO2 foams.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138733"},"PeriodicalIF":7.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effective extraction of larch holocellulose with alkaline deep eutectic solvent and production of furan chemicals with the coordination of temperature-controlled polyoxometalates and metal salt in biphasic system. 碱性深共熔溶剂对落叶松纤维素的有效萃取及双相体系中温控多金属氧酸盐与金属盐配合生产呋喃类化学品。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-02-01 Epub Date: 2024-12-11 DOI: 10.1016/j.ijbiomac.2024.138721

Xuesong Zhang, Qingguo Wang, He Wan, Yongwei Han, Wenbiao Xu, Xiangyu Li, Xixin Duan, Junyou Shi

{"title":"Effective extraction of larch holocellulose with alkaline deep eutectic solvent and production of furan chemicals with the coordination of temperature-controlled polyoxometalates and metal salt in biphasic system.","authors":"Xuesong Zhang, Qingguo Wang, He Wan, Yongwei Han, Wenbiao Xu, Xiangyu Li, Xixin Duan, Junyou Shi","doi":"10.1016/j.ijbiomac.2024.138721","DOIUrl":"10.1016/j.ijbiomac.2024.138721","url":null,"abstract":"This study focused on extracting holocellulose from Changbai larch waste, which is rich in hexose and beneficial for furan chemicals production. Various alkaline deep eutectic solvents (DESs) was applied in the extraction of holocellulose. DES composed of lysine (Lys) and 2-aminoethanol (MEA) with strong alkalinity had a superior ability to remove lignin, and the purity of holocellulose could reach 82.7 %. Consequently, a double-acid system formed by a temperature-controlled polyoxometalates catalyst (ChnH3-nPW12, n = 1, 2, 3,) prepared by choline chloride (ChCl) and phosphotungstic acid (H3PW12O40) and different metal salts were used in the hydrolysis of holocellulose to 5-hydroxymethylfurfural (HMF) and 2-furaldehyde (FF) in a two-phase system of water and organic solvent. The yields of HMF and FF reached 43.5 % and 78.2 %, respectively, when ChH2PW12 and AlCl3 were employed under the conditions of 10 mL water/methyl isobutyl ketone (MIBK) (1:9, V:V), 9 h, and 150 °C. ChH2PW12is easy to recycle and can be used up to 5 times. This study offers a novel strategy to retain as much hemicellulose as possible to achieve holocellulose by alkaline DESs, and the one-pot process by the coordination of polyoxometalates and metal salt provides a simultaneous production of high-value furan chemicals from larch waste.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138721"},"PeriodicalIF":7.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional characterization of β-adrenergic-like octopamine receptors in planthopper reproduction and feeding. β-肾上腺素样章鱼胺受体在飞虱繁殖和摄食中的功能特征。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-02-01 Epub Date: 2024-12-11 DOI: 10.1016/j.ijbiomac.2024.138722

Yuanyuan Zhang, Mingshi Qian, Chenjia Shao, Liran Fu, Liang Wu, Ruhao Qian, Meiqi Xu, Jing Lu, Gang Xu, Guoqing Yang

{"title":"Functional characterization of β-adrenergic-like octopamine receptors in planthopper reproduction and feeding.","authors":"Yuanyuan Zhang, Mingshi Qian, Chenjia Shao, Liran Fu, Liang Wu, Ruhao Qian, Meiqi Xu, Jing Lu, Gang Xu, Guoqing Yang","doi":"10.1016/j.ijbiomac.2024.138722","DOIUrl":"10.1016/j.ijbiomac.2024.138722","url":null,"abstract":"As an essential biogenic amine in invertebrates, octopamine (OA) regulates multiple physiological and behavioral processes via binding to octopamine receptors (OARs). The small brown planthopper Laodelphax striatellus is an important agricultural pest. However, little is known about OARs in L. striatellus. Herein, three β-adrenergic-like OARs (LsOA2s) were cloned, including LsOA2B1, LsOA2B2, and LsOA2B3. LsOA2s were expressed at the highest levels in egg stage and brain. Knockdown of LsOA2s significantly decreased the transcript levels of vitellogenin (LsVg) and Vg receptor (LsVgR), and reduced LsVg protein levels. LsOA2B2 knockdown shortened the oviposition period and inhibited the fecundity, while silencing LsOA2B1 and LsOA2B3 did not affect the reproduction performance including the preoviposition period, oviposition period, and fecundity. Ovary dissection indicated that LsOA2B2 knockdown decreased the ovary area and detained eggs. In addition, LsOA2s silencing prolonged the hatching period and reduced the hatching rate, and shortened the egg length on the fifth day of development. LsOA2B2 silencing also reduced egg width. Furthermore, LsOA2s knockdown decreased honeydew excretions of adults. Overall, these results provide evidence that LsOA2s play important roles in the reproduction and feeding behaviors of L. striatellus, and offer a reference for the exploration of potential molecular targets to control planthoppers.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138722"},"PeriodicalIF":7.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of mono-nuclear cobalt(II) complexes with a tri-dentate quinoxalyl-hydrazone ligand for their potential in biological research and interaction with ct-DNA. 研究具有三齿喹喔啉-腙配体的单核钴（II）配合物在生物研究中的潜力以及与 ct-DNA 的相互作用。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-02-01 Epub Date: 2024-12-16 DOI: 10.1016/j.ijbiomac.2024.138617

Arwa A Makki, Dina Hajjar, Ahmed Desoky M Mohamad, Omran A Omran, Mohamed Shaker S Adam

{"title":"Investigation of mono-nuclear cobalt(II) complexes with a tri-dentate quinoxalyl-hydrazone ligand for their potential in biological research and interaction with ct-DNA.","authors":"Arwa A Makki, Dina Hajjar, Ahmed Desoky M Mohamad, Omran A Omran, Mohamed Shaker S Adam","doi":"10.1016/j.ijbiomac.2024.138617","DOIUrl":"10.1016/j.ijbiomac.2024.138617","url":null,"abstract":"The condensing reaction of 2-hydroxy-1-naphthaldehyde with quinoxalyl-2-carbohydrazide resulted in synthesizing of a novel derivative of hydrazone quinoxalyl ligand (H2dpq). The bonding behavior between H2dpq and Co(II) ion was investigated in molar ratios of 1: 1 and 2: 1 to produce two different complexes, Codpq and Co(dpq)2, respectively. Their chemical structure was verified using several spectroscopic approaches. The characterization envolved micro-C, H, and N-elemental analyses, thermogravimetric investigations, as well as the examination of their magnetic and conductance properties. The inhibitory effects of H2dpq (the free ligand) and its Co(II)-chelates on the growing up of three specific bacterial series, three specific fungal series, and three famous human cancer cell lines were evaluated based on their structure features. The study referred to the pivotal function of Co(II) and its ratio in the two complexes. The antioxidant activity was determined for all current compounds within DPPH and SOD assays, reporting respectable antioxidant reactivity. The interaction of H2dpq, Codpq, and Co(dpq)2 with calf thymus DNA (ct-DNA) was assessed by analyzing through the alterations in the viscometric and spectrophotometric properties. Determination of binding constant (Kb, 13.12, 16.02, and 16.82 × 107 mol-1 dm3), Gibb's free energy (∆Gb≠, were -40.21, -46.13, and -46.67 kJ mol-1), and the chromism mode (hypo-character) were employed for H2dpq, Codpq, and Co(dpq)2 to assess the interactive modes, respectively. Rewardingly, the monometallic-chelates Co(II)-complexes displayed modified binding action more than that of H2dpq against ct-DNA.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138617"},"PeriodicalIF":7.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and characterization of Levan composite film incorporating vanillin for use as a potential edible coating for peony seed oil. 制备含有香兰素的莱万复合薄膜并确定其特性，以用作牡丹籽油的潜在食用涂层。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-02-01 Epub Date: 2024-12-16 DOI: 10.1016/j.ijbiomac.2024.138732

Min Xu, Lixia Zhang, Yihong Zeng, Zhijiang Zhou, Ye Han

{"title":"Preparation and characterization of Levan composite film incorporating vanillin for use as a potential edible coating for peony seed oil.","authors":"Min Xu, Lixia Zhang, Yihong Zeng, Zhijiang Zhou, Ye Han","doi":"10.1016/j.ijbiomac.2024.138732","DOIUrl":"10.1016/j.ijbiomac.2024.138732","url":null,"abstract":"The study prepared an edible packaging material for peony seed oil by adding natural antioxidant vanillin to a microbial Levan composite film. The presence of highly branched Levan, containing polyhydroxyl groups, significantly enhanced the maximum tension (26.57 N), tensile strength (36.31 MPa), and elongation at break (42.15 %) of the Aga/Lev film. The values were 9.84-fold, 5.74-fold, and 1.11-fold higher than those of Aga films, respectively. Furthermore, SEM and FTIR analysis revealed that Levan increased the intermolecular force of the vanillin composite film (Aga/Lev/Gly/Van), forming a dense gel network with a Schiff base reaction occurring between vanillin and glycine. The addition of vanillin and glycine slightly lowered the transparency of the film but enhanced the ultra violet (UV)-blocking with 100 % UV-region and 91 % visible region light screening. The Aga/Lev/Gly/Van films showed strong antioxidant efficacy with 91.85 % ABTS and 44.33 % DPPH radical scavenging potential. The electrical conductivity, P-anisidine value, thiobarbituric acid value, and fatty acid distribution of peony seed oil samples were analyzed after accelerated storage. The Aga/Lev/Gly/Van group had a significantly higher retention rate (95.65 %) for total conjugated fatty acids compared to the control group (84.17 %). The utilization of Aga/Lev/Gly/Van film packaging effectively extended the shelf life of peony seed oil and retarded the degradation of unsaturated fatty acids in the oil. Therefore, Levan composite films incorporating vanillin can be used as sustainable packaging materials to minimize the oxidation of susceptible foods.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138732"},"PeriodicalIF":7.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revolutionizing photocatalysis: Synthesis of innovative poly(N-tertiary-butylacrylamide)-graft-hydroxypropyl cellulose polymers for thermo-responsive applications via metal-free organic photoredox catalysis. 光催化革命：通过无金属有机光氧化催化合成创新型聚（N-叔丁基丙烯酰胺）接枝羟丙基纤维素聚合物，用于热响应应用。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-02-01 Epub Date: 2024-12-14 DOI: 10.1016/j.ijbiomac.2024.138775

Muhammad Asif Iqbal, Muhammad Wasim Younis, Muhammad Maqbool, Hui Hwang Goh, Tonni Agustiono Kurniawan, Muhammad Amjad, Mohd Hafiz Dzarfan Othman

{"title":"Revolutionizing photocatalysis: Synthesis of innovative poly(N-tertiary-butylacrylamide)-graft-hydroxypropyl cellulose polymers for thermo-responsive applications via metal-free organic photoredox catalysis.","authors":"Muhammad Asif Iqbal, Muhammad Wasim Younis, Muhammad Maqbool, Hui Hwang Goh, Tonni Agustiono Kurniawan, Muhammad Amjad, Mohd Hafiz Dzarfan Othman","doi":"10.1016/j.ijbiomac.2024.138775","DOIUrl":"10.1016/j.ijbiomac.2024.138775","url":null,"abstract":"In this study, we present a groundbreaking approach utilizing metal-free, visible light-mediated organic photoredox catalyzed atom transfer radical polymerization (O-ATRP) to synthesize cellulose-based stimuli-responsive polymers. Our method resulted in the successful synthesis of innovative metal-free poly(N-tertiary-butylacrylamide)-graft-hydroxypropyl cellulose (PNTBAM-g-HPC) polymers with exceptional control over molecular weight and narrow dispersity index (Đ) and explored their applications in organo-photocatalytic reactions. This approach addresses the limitations of traditional atom transfer radical polymerization method, which suffer from metal contamination and toxicity related problems. O-ATRP and organic photoredox catalysts have been sought to address these difficult challenges. In this study, we synthesized organic compound; 2,4,5,6-tetrakis(diphenylamino)isophthalonitrile (4DPIPN), which served as an organic photoredox catalyst, enabling the synthesis and application study of PNTBAM-g-HPC polymers via organic photoredox catalysis. Furthermore, by employing 4DPIPN, three different types of PNTBAM-g-HPC polymers were synthesized. Through thorough characterization techniques including FTIR, NMR, UV/Visible spectroscopy, TGA, and GPC analysis, we confirmed the successful synthesis of photocatalyst and three different types of PNTBAM-g-HPC polymers under O-ATRP conditions. By adjusting the molar ratios of PNTBAM side chains, we fine-tuned the LCST of HTA-20 polymers to 37.3 °C, demonstrating their thermoresponsive behavior. This synthetic approach shows great potential for applications in biosensors, pharmaceuticals, biomedical engineering, and drug delivery systems.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138775"},"PeriodicalIF":7.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

American ginseng vesicles loaded hyaluronic acid hydrogel for ulcerative colitis. 西洋参小泡装透明质酸水凝胶治疗溃疡性结肠炎。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-02-01 Epub Date: 2024-12-09 DOI: 10.1016/j.ijbiomac.2024.138565

Ling Weng, Min Zhao, Yumeng Zhang, Xinyu Liu, Zheyong Wang, Ruixiang Xu, Jiayi Zhang, Yingjie Wang, Miao Wang, Chunjie Zhao

{"title":"American ginseng vesicles loaded hyaluronic acid hydrogel for ulcerative colitis.","authors":"Ling Weng, Min Zhao, Yumeng Zhang, Xinyu Liu, Zheyong Wang, Ruixiang Xu, Jiayi Zhang, Yingjie Wang, Miao Wang, Chunjie Zhao","doi":"10.1016/j.ijbiomac.2024.138565","DOIUrl":"10.1016/j.ijbiomac.2024.138565","url":null,"abstract":"The present study introduces a novel therapeutic approach for ulcerative colitis (UC) utilizing American ginseng vesicles encapsulated within a hyaluronic acid (HA) hydrogel matrix. UC, a prevalent form of inflammatory bowel disease, is characterized by chronic inflammation of the colonic mucosa, leading to significant morbidity and compromised quality of life. Existing therapeutic modalities such as 5-Aminosalicylic acid (5-ASA) are associated with substantial side effects and a high recurrence rate. Thus, there is an unmet need for alternative treatments that offer enhanced efficacy with reduced adverse effects. Leveraging the anti-inflammatory properties of American ginseng vesicles HA -hydrogels of HA hydrogel (5-ASA + ANPs@HA), this study presents a targeted drug delivery system designed to provide localized therapy for UC. We synthesized the hydrogel matrix by HA and 1,4-butanediol diglycidyl ether (BDDE) at concentrations of 1 % NaOH and 0.8 %, v/v, respectively. The water content of the hydrogel was about 80 % to 90 %, and 82 % of Rb1 was released in 61 min. Our results demonstrate a significant reduction in disease symptoms, a substantial decrease in pro-inflammatory cytokines, and marked enhancement in mucosal healing following treatment with the 5-ASA + ANPs@HA. Collectively, these results suggest that the 5-ASA + ANPs@HA represents a promising therapeutic strategy for UC, warranting further investigation for clinical application.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138565"},"PeriodicalIF":7.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A biomimetic injectable chitosan/alginate hydrogel biocopmosites encapsulating selenium- folic acid nanoparticles for regeneration of spinal cord injury: An in vitro study. 包裹硒-叶酸纳米粒子的生物仿生注射壳聚糖/精氨酸水凝胶生物复合材料用于脊髓损伤的再生：体外研究。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-02-01 Epub Date: 2024-12-11 DOI: 10.1016/j.ijbiomac.2024.138682

Mahan Farzan, Mostafa Soleimannejad, Saeedeh Shariat, Mina Heidari Sureshjani, Abolfazl Gholipour, Korosh Ashrafi Dehkordi, Seyed Mohammad Reza Alerasoul Dehkordi, Mahour Farzan

{"title":"A biomimetic injectable chitosan/alginate hydrogel biocopmosites encapsulating selenium- folic acid nanoparticles for regeneration of spinal cord injury: An in vitro study.","authors":"Mahan Farzan, Mostafa Soleimannejad, Saeedeh Shariat, Mina Heidari Sureshjani, Abolfazl Gholipour, Korosh Ashrafi Dehkordi, Seyed Mohammad Reza Alerasoul Dehkordi, Mahour Farzan","doi":"10.1016/j.ijbiomac.2024.138682","DOIUrl":"10.1016/j.ijbiomac.2024.138682","url":null,"abstract":"Spinal cord injury (SCI) poses significant challenges to regenerative medicine due to its limited self-repair capabilities. In this study, we engineered a biomimetic injectable hydrogel using modified chitosan and alginate biopolymers encapsulating selenium-folic acid nanoparticles (Se-FA NPs) to facilitate SCI regeneration. The hydrogel exhibited a unique porous structure attributed to the incorporation of nanofiber fragments, enhancing its biocompatibility and bioactivity. Through a series of in vitro evaluations, including cell viability assays, proliferation studies, gene expression analysis, we assessed the hydrogel's cytocompatibility and its potential for supporting neural cell growth. Our results demonstrate the promising efficacy of the hydrogel in providing a conducive microenvironment for neural tissue regeneration. Moreover, the sustained release of Se-FA NPs from the hydrogel system offers neuroprotective, antioxidative, and anti-inflammatory benefits crucial for SCI therapy. Overall, our biomimetic hydrogel biocomposites hold great potential as a therapeutic strategy for promoting spinal cord regeneration, highlighting their significance in advancing the field of regenerative medicine.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138682"},"PeriodicalIF":7.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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