International Journal of Biological Macromolecules最新文献

{"title":"Robust gelatin/dialdehyde starch biofoams via yeast-induced in situ foaming: fabrication and properties","authors":"Yu Duan ,&nbsp;Zhen Zhang ,&nbsp;Long Zhang","doi":"10.1016/j.ijbiomac.2026.152102","DOIUrl":"10.1016/j.ijbiomac.2026.152102","url":null,"abstract":"<div><div>Bio-based porous carriers are widely used for controlled release, but pores formed under mild conditions in natural polymer matrices often come at the cost of structural integrity. In addition, conventional chemical foaming and crosslinking can introduce safety concerns. Here we couple yeast fermentation–driven foaming with Schiff-base crosslinking between gelatin and dialdehyde starch (DAS), so that the evolving bubble-derived pore structure can be progressively retained while pore walls consolidate into a three-dimensionally porous composite (GDS). FT-IR indicated imine formation between DAS aldehydes and gelatin ε-amino groups, with strong hydrogen-bonding interactions also evidenced. SEM showed an open, honey_comb-like network with a maximum porosity of 72.6%, whereas the yeast-free control reached only ∼19%. Even at high porosity, the crosslinked walls preserved shape after swelling, and the GDS samples showed improved thermal stability, reflected by a shift of the main degradation region toward higher temperatures. Aspirin (ASP) loading in the optimized matrix (ASP@GDS-4/70/6) produced biphasic release in PBS (pH 7.4): an early fraction (M_1h = 35.4%), close to a commercial 75 mg sustained-release aspirin tablet (30.6%), followed by a longer sustained-release phase (t₉₅ = 8 h vs 6 h). Overall release followed a first-order model (R² = 0.993). For M_t/M_∞ ≤ 0.60, Korsmeyer–Peppas fitting gave <em>n</em> = 0.66 (R² = 0.967), consistent with non-Fickian transport arising from coupled diffusion and polymer relaxation. This coupled foaming-and-crosslinking approach offers a mild route to interconnected porosity in natural polymer matrices.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"364 ","pages":"Article 152102"},"PeriodicalIF":8.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147727878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable hyaluronic acid hydrogels for the treatment of ocular diseases: A review","authors":"Zhengwei Ge ,&nbsp;Zekai Jia ,&nbsp;Yang Liu ,&nbsp;Han Zhang","doi":"10.1016/j.ijbiomac.2026.152112","DOIUrl":"10.1016/j.ijbiomac.2026.152112","url":null,"abstract":"<div><div>Globally, an increasing number of individuals suffer from ocular diseases, including dry eye syndrome, corneal injuries, and age-related macular degeneration (AMD), ultimately leading to visual impairment or complete blindness. The complex anatomy and physiological barriers of the eye limit the efficacy of conventional therapies such as eye drops and intraocular injections, while also posing challenges including frequent dosing requirements and inflammatory risks. Injectable hyaluronic acid (HA) hydrogels present a promising strategy to address the limitations of current ocular therapies, owing to their excellent biocompatibility, tunable physicochemical properties (including optical transparency and mechanical modulus), and sustained drug release capabilities. Recent research continues to explore the potential of functionalized injectable HA hydrogels to advance ophthalmic treatment paradigms. This review summarizes recent advances in the chemical modification and crosslinking strategies of HA, as well as innovative design concepts for functionalized injectable HA hydrogels in treating ocular disorders such as corneal injuries and AMD. Injectable HA hydrogels show considerable promise for improving therapeutic outcomes, reducing treatment frequency and side effects, lowering healthcare costs, and enhancing patient compliance. This review aims to provide theoretical support for the future development of emerging HA hydrogel-based platforms for ocular care.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"364 ","pages":"Article 152112"},"PeriodicalIF":8.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147727881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative modification of skin collagen","authors":"Vendula Paculová ,&nbsp;René Lenobel ,&nbsp;Ankush Prasad ,&nbsp;Pavel Pospíšil","doi":"10.1016/j.ijbiomac.2026.152174","DOIUrl":"10.1016/j.ijbiomac.2026.152174","url":null,"abstract":"<div><div>Oxidative modification of collagen contributes to the loss of skin structure and function during aging and disease. Although reactive oxygen species are known to damage collagen, the radical intermediates and fragmentation mechanism responsible for collagen degradation remain poorly understood. In this study, we investigated whether azocompound-derived peroxyl radicals induce collagen fragmentation through the formation of protein radicals (carbon-centered) and alkoxyl radicals (oxygen-centered) in skin tissue. Using EPR spectroscopy, fluorescence analysis, immunoblotting, and LC–MS/MS profiling, we demonstrated that hydrogen abstraction from collagen generates protein radicals, which are subsequently converted to alkoxyl radicals. We further show that these alkoxyl radicals may undergo β-scission, leading to cleavage between the α‑carbon of the collagen backbone and the C-3 carbon of the amino acid side chain. This process promotes side-chain detachment and contributes to fragmentation of collagen type I. Because collagen accounts for approximately 75% of the dry weight of skin and type I collagen represents 80–90% of total dermal collagen, oxidative fragmentation of collagen may substantially impair skin integrity and contribute to skin aging as well as to pathological tissue remodeling associated with fibrotic, autoimmune, and skin neoplastic diseases.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"363 ","pages":"Article 152174"},"PeriodicalIF":8.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium lignosulfonate and tannic acid assisted exfoliation and functionalization of molybdenum disulfide for multifunctional polyurethane adhesive","authors":"Hongyu Chen ,&nbsp;Shicun Jin ,&nbsp;Kuang Li ,&nbsp;Rui Sun ,&nbsp;Licheng Li ,&nbsp;Huining Xiao","doi":"10.1016/j.ijbiomac.2026.152167","DOIUrl":"10.1016/j.ijbiomac.2026.152167","url":null,"abstract":"<div><div>Biobased polyurethane adhesives play a critical role in advanced manufacturing. However, their limited bonding strength and insufficient functionality significantly constrain their application scope and further development. In this study, a novel castor oil-based polyurethane adhesive with excellent bonding strength, flame retardancy, and photothermal conversion capability was developed by introducing functionalized MoS₂ nanocomposites. We employed a tannic acid (TA)- and lignin-assisted ball milling and aqueous exfoliation approach to simultaneously exfoliate and non-covalently functionalize MoS₂ nanosheets. The phenolic hydroxyl groups of TA and sulfonic acid groups of lignin not only facilitated the exfoliation process but also enhanced the interfacial compatibility between MoS₂ and the polymer matrix. Notably, digital image correlation analysis clearly demonstrates the robust stress-transfer capability of the prepared adhesive. This is directly reflected in its dry and wet shear strength, which reached 8.1 and 4.1 MPa, respectively, corresponding to remarkable increases of 88.4% and 95.2% compared to the unmodified polyurethane adhesive. Moreover, the prepared adhesive exhibits remarkable flame retardancy, high photothermal conversion capability, and strong environmental reliability in alkaline, aqueous, acidic, and saline solutions. This work provides a feasible and sustainable approach for developing next-generation multifunctional biobased polyurethane adhesives.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"363 ","pages":"Article 152167"},"PeriodicalIF":8.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of bio-based lignin-TiO2/PVA composite films for active food packaging","authors":"Sirirat Thammasang ,&nbsp;Supranee Phanthanawiboon ,&nbsp;Hiroshi Uyama ,&nbsp;Somnuk Theerakulpisut ,&nbsp;Khanita Kamwilaisak","doi":"10.1016/j.ijbiomac.2026.152189","DOIUrl":"10.1016/j.ijbiomac.2026.152189","url":null,"abstract":"<div><div>The development of bio-based active functional additive materials for food packaging has emerged as a key area of research. Lipid oxidation in food products significantly compromises quality by inducing off-odors, rancidity, and eventual spoilage. To access this point, this study explores the practical application of a lignin-TiO₂ composite as an additive in packaging films. The Taguchi method, combined with grey relational analysis, was used to optimize lignin-TiO₂ composite for improving antibacterial, antioxidant, and UV-blocking properties. The 3% lignin-TiO₂/PVA film blocked 98.49% of UV light while maintaining 61.41% transparency, enhancing thermal management by reducing heat accumulation and keeping the temperature 1.33 °C lower than the bare film. Incorporation of 3% lignin-TiO₂ composite into the film was found to enhance barrier properties by creating complex pathways that restricted the permeation of water and oxygen molecules. Additionally, mechanical properties of the film improved, with tensile strength and elongation at rupture increasing by 14.09% and 8.95%, respectively. Moreover, the composite film effectively reduced lipid oxidation in lipid-rich foods, significantly delaying malondialdehyde (MDA) formation over a 30-day storage period and demonstrated biocompatibility with Vero cells, highlighting its potential for non-toxic application in food packaging. Overall, this study presents a promising strategy for extending the shelf life of food products while promoting the utilization of lignin, an otherwise wasted material, and contributing to environmental sustainability.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"363 ","pages":"Article 152189"},"PeriodicalIF":8.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dendrobium officinale polysaccharide–spermidine composite hydrogels: Tunable rheological properties and improved in vitro colonic fermentation","authors":"Hui Duan ,&nbsp;Jinwei Li ,&nbsp;Leilei Yu ,&nbsp;Liuping Fan ,&nbsp;Weibiao Zhou","doi":"10.1016/j.ijbiomac.2026.152209","DOIUrl":"10.1016/j.ijbiomac.2026.152209","url":null,"abstract":"<div><div><em>Dendrobium officinale</em> polysaccharide (DOP) and spermidine (Spd) exhibit synergistic anti-aging effects in <em>Caenorhabditis elegans</em>, suggesting potential functional complementarity. Here, a DOP–Spd composite hydrogel (DS) was constructed to integrate structural tunability with fermentation-related functionality. Three weight ratios (18:2, 18:4, and 18:6, DOP:Spd) successfully formed hydrogels. Increasing Spd content enhanced gel strength and thermal stability, as reflected by higher hardness (149.62–353.75 g), chewiness (41.04–119.07), and DTG peak temperature (331.7–334.0 °C). All DS hydrogels exhibited shear-thinning and a clear linear viscoelastic region (0.1%–1.0% strain). Among them, the 18:2 formulation showed superior water holding capacity (76.41%) and was selected for subsequent digestion and fermentation studies due to its suitability for moderate dysphagia. The results showed that approximately 80% of the polysaccharide passed through the upper gastrointestinal tract and reached the colon in both DOP and the DS hydrogel. Both promoted the growth of beneficial taxa (e.g., <em>Bifidobacterium</em>). DS markedly promoted <em>B. pseudocatenulatum</em>, <em>B. longum</em>, <em>B. ruminantium</em>, <em>Prevotella_2</em> and <em>Bacteroides</em>, while inhibiting <em>Enterococcus</em> and <em>Flavonifractor</em>. Functional prediction showed enhanced pathways related to carbohydrate and energy metabolism. Metabolomic analysis (OPLS-DA) revealed clear group separation. Compared with DOP, DS increased key metabolites, including propionic acid (1.40-fold), butyric acid (1.98-fold), malic acid (3.94-fold), NAD⁺ (2.87-fold), adenosine (4.16-fold), hypoxanthine (2.26-fold), and serotonin (2.43-fold), with pathway enrichment in pyruvate, galactose, glyoxylate/dicarboxylate, purine, and starch/sucrose metabolism, as well as the citrate cycle. These results demonstrate that the DOP–Spd (18:2) hydrogel integrates desirable rheological properties with improved microbiota-associated functionality, supporting its potential as a dual-functional food matrix.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"364 ","pages":"Article 152209"},"PeriodicalIF":8.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dual role of monoacylglycerol lipase (MAGL) in cancer: From oncogenesis to tumor suppression and therapeutic targeting: A review","authors":"Wei Ning ,&nbsp;Baojun Shen ,&nbsp;Yang Hong,&nbsp;Yanqing Du,&nbsp;Lu Ga","doi":"10.1016/j.ijbiomac.2026.152316","DOIUrl":"10.1016/j.ijbiomac.2026.152316","url":null,"abstract":"<div><div>As a core metabolic enzyme of the endocannabinoid system (ECS) and a key regulatory factor in lipid metabolic reprogramming, monoacylglycerol lipase (MAGL) exhibits a unique dual role in tumorigenesis and progression. This article systematically reviews the role of MAGL in tumors and provides a comprehensive summary of the development progress of MAGL inhibitors in tumors, including the structural characteristics, mechanisms of action, and pharmacological activities of irreversible and reversible inhibitors, with a focus on analyzing the advantages and limitations of various inhibitors. In addition, this paper also explores combination therapy based on MAGL, providing new ideas for tumor treatment. At the same time, the article prospects the application potential of MAGL as a clinical therapeutic target.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"364 ","pages":"Article 152316"},"PeriodicalIF":8.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinspired zein-chitosan nanocomplexes for co-delivery of 5-fluorouracil and silibinin: Optimization, characterization and anticancer activity in colorectal cancer","authors":"Shyam Sudhakar Gomte ,&nbsp;Jyoti Bishlay ,&nbsp;Amit Kumar Pandey ,&nbsp;Aakanchha Jain","doi":"10.1016/j.ijbiomac.2026.152296","DOIUrl":"10.1016/j.ijbiomac.2026.152296","url":null,"abstract":"<div><div>Colorectal cancer (CRC) is one of the most significant global health concerns, necessitating innovative therapeutic strategies for its effective management. Despite advances in treatment therapies, chemotherapy remains the mainstay of CRC treatment, with 5-Fluorouracil (5-FU) as a standard first-line agent. However, its clinical effectiveness is hindered by drug resistance, rapid clearance and systemic toxicity, underscoring the need for innovative drug delivery strategies. In this context, the current work involves engineering of a bioinspired nanocomplex (NX) comprising zein and a biological macromolecule, such as chitosan, using a Quality by Design (QbD) approach. The resulting NX was characterized for particle size (186.13 ± 8.61 nm), polydispersity index (0.194 ± 0.03), and %entrapment of 5-FU (54.39 ± 3.1%) and silibinin (97.44 ± 1.16%), respectively. SEM and TEM analysis revealed the smooth and spherical nature of NX. Thermal analysis was performed using TGA and DSC and XRD was employed for structural characterization. Subsequently, spectroscopic investigations were carried out using FTIR, Raman and fluorescence spectroscopy to examine the potential interactions between the drugs and polymers used in the formulation of the NX system. In vitro studies confirmed controlled drug release with Weibull release kinetic model. The dual-drug-loaded-NX exhibited a significant increase in cytotoxicity compared to individual 5-FU and silibinin, and achieving nearly a 5-fold increase in cytotoxicity compared to silibinin. The NX demonstrated apoptosis induction, S/G₂ cell cycle arrest, and improved cellular uptake compared to control group. The current investigation suggests that QbD-engineered zein-chitosan-based-NX could be a promising therapeutic strategy for managing CRC.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"364 ","pages":"Article 152296"},"PeriodicalIF":8.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan/cassava starch films incorporated with purple sweet potato anthocyanin for pH-responsive pork freshness monitoring","authors":"Jingming Zhang,&nbsp;Jiayi Cai,&nbsp;Tengchao Li,&nbsp;Dongfang Chen,&nbsp;Shirong Huang","doi":"10.1016/j.ijbiomac.2026.152326","DOIUrl":"10.1016/j.ijbiomac.2026.152326","url":null,"abstract":"<div><div>This study developed a pH-responsive film using purple sweet potato anthocyanin (PSPA) as an indicator and a chitosan (CH)/cassava starch (CS) blend as the film-forming matrix for real-time monitoring of pork freshness at 25 °C and 4 °C. Incorporation of 0.03% PSPA enabled the film to maintain high color responsiveness while improving mechanical performance, with tensile strength (41.50 MPa) and elongation at break (23.85%) increasing by 47.6% and 92.3%, respectively, compared to the control film. Instrumental analysis confirmed that PSPA was dispersed amorphously within the CH/CS matrix, and hydrogen bonds were formed among the three components, enhancing the structural compactness and reducing the crystallinity of the film. Molecular docking and density functional theory calculations were innovatively employed to visualize the molecular interactions between PSPA and the CH/CS matrix. Results revealed that hydrogen bonding and van der Waals interactions formed among the three components under pH 4.4, which was further corroborated by molecular dynamics simulations. These findings provide a theoretical basis for the improved mechanical properties and structural compactness of the film. In pork freshness monitoring over both 30 h at 25 °C and 9 d at 4 °C, the film exhibited distinct colorimetric changes from blue to gray-green and finally to yellowish-brown (ΔE &gt; 5), accurately corresponding to the fresh, sub-fresh, and spoiled states of the pork. This work established a multi-scale relationship from molecular interactions to microstructure and ultimately to macroscopic film properties, providing new insights for designing anthocyanin-loaded polysaccharide-based smart packaging from the perspective of molecular interaction mechanisms.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"364 ","pages":"Article 152326"},"PeriodicalIF":8.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of antifungal albumin-based films for use as catheter dressing","authors":"Sílvia Moreira Ferreira ,&nbsp;Leonardo Medeiros ,&nbsp;Camila Angela Gonzatti ,&nbsp;Paula Reginatto ,&nbsp;Tales S. Daitx ,&nbsp;Vinícius C. De Franco ,&nbsp;Diego Santiago Tupuna-Yerovi ,&nbsp;Mário Lettieri Teixeira ,&nbsp;Alexandre Meneghello Fuentefria ,&nbsp;Roberta Bussamara","doi":"10.1016/j.ijbiomac.2026.152212","DOIUrl":"10.1016/j.ijbiomac.2026.152212","url":null,"abstract":"<div><div>The fungal infection caused by <em>Candida albicans</em> in central venous catheters is severe, and patient survival is strongly linked to early source control of the medical devices. To mitigate this problem, egg albumin-based films containing clioquinol were produced through a casting method to develop an antifungal barrier for catheters. To enhance the films' mechanical properties, glycerol was added as a plasticizer. The development of albumin-based films was optimized. Thermogravimetric, FTIR-ATR, AFM, adhesiveness and mechanical analyses were performed. In addition, antimicrobial activity was investigated. Irritability assay and histopathological evaluation were also conduct. The results demonstrated that incorporating 3.0% glycerol into the albumin films significantly enhanced their mechanical properties, providing ideal characteristics for use as catheter dressings. All albumin-based films with 3.0% glycerol and with or without clioquinol exhibited excellent antimicrobial activity against <em>C. albicans.</em> Moreover, these films exhibited moderate adhesion to skin and showed no irritating or damage potential, making them biocompatible and safe for application on skin. These findings suggest that albumin-based films are promising candidates for effective and environmentally friendly catheter dressings that prevent <em>C. albicans</em> infections.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"363 ","pages":"Article 152212"},"PeriodicalIF":8.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}