International Journal of Biological Macromolecules最新文献_第7页

Stabilizing zinc anodes with sodium lignosulfonate-doped polypyrrole.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-02-04 DOI: 10.1016/j.ijbiomac.2025.140691

Yaqi Ni, Qifan Liu, Tao Xue, Limin Zang, Xiuwen Yu, Jiali Zhang, Chao Yang

引用次数: 0

Single-nucleus RNA sequencing decodes abnormal cell-collagen communication in a sheep endometrial fibrosis model.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-02-05 DOI: 10.1016/j.ijbiomac.2025.140628

Tingting Chu, Jiashun Tong, Zhongshi Zhu, Guoliang Zhang, Yunan Weng, Lei Sun, Le Sun, Jiuzeng Cui, Jiaxin Liu, Yuhang Xiao, Lei Zhang, Yuxuan Song

{"title":"Single-nucleus RNA sequencing decodes abnormal cell-collagen communication in a sheep endometrial fibrosis model.","authors":"Tingting Chu, Jiashun Tong, Zhongshi Zhu, Guoliang Zhang, Yunan Weng, Lei Sun, Le Sun, Jiuzeng Cui, Jiaxin Liu, Yuhang Xiao, Lei Zhang, Yuxuan Song","doi":"10.1016/j.ijbiomac.2025.140628","DOIUrl":"10.1016/j.ijbiomac.2025.140628","url":null,"abstract":"Endometrial fibrosis in sheep reduces reproductive performance with elusive therapeutic targets. The fibrotic endometrium is a complex ecosystem with heterogeneous cells and their interactions. The molecular characterization of key cells and the mechanisms of these interactions are unclear. To uncover the key molecular features of sheep endometrial fibrosis tissue, we used single-nucleus RNA sequencing to profile the transcriptional characterization of sheep endometrial cells from both normal and fibrotic tissues, aiming to clarify the mechanisms of fibrosis development. Histomorphological analysis revealed significant collagen deposition in fibrotic endometrial tissue. The transcription atlas of sheep endometrial cells was created, identifying eight main endometrial cell types. Key findings include the abnormal expression of collagen-related genes in fibrotic cells and the identification of endothelial cells and fibroblasts as major contributors to fibrogenesis with aberrant receptor-ligand interactions involving collagen-related genes. Fibroblasts had a tendency to differentiate into myofibroblasts in fibroblast-mediated fibrosis progression. In vitro experiments demonstrated the role of fibroblasts in fibroblast activation through the PERK/eIF2α/CHOP stress pathway. Additionally, fibrosis disturbs the immune microenvironment. This study highlights that high collagen gene expression in injured endometrial cells leads to abnormal tissue repair and fibrosis, offering valuable insights for understanding endometrial fibrosis at the single-cell level.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"140628"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deletion of p75NTR rescues behavioral and cognitive dysfunction in SPS-induced PTSD mice through hippocampal PI3K/Akt/mTOR pathway

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 DOI: 10.1016/j.ijbiomac.2025.142770

Yu-Yuan Peng , Jun-Jie Tang , Sen Li , Can Tang , Yang Ding , Hui Cheng , Hai-Yan Wang , Zai-Yun Long , Xiu-Min Lu , Yong-Tang Wang

{"title":"Deletion of p75NTR rescues behavioral and cognitive dysfunction in SPS-induced PTSD mice through hippocampal PI3K/Akt/mTOR pathway","authors":"Yu-Yuan Peng , Jun-Jie Tang , Sen Li , Can Tang , Yang Ding , Hui Cheng , Hai-Yan Wang , Zai-Yun Long , Xiu-Min Lu , Yong-Tang Wang","doi":"10.1016/j.ijbiomac.2025.142770","DOIUrl":"10.1016/j.ijbiomac.2025.142770","url":null,"abstract":"<div><div>Post-traumatic stress disorder (PTSD) is a persistent mental illness caused by severe traumatic events, and its pathogenesis is still unclear. Recent studies indicate that p75 neurotrophic factor receptor (p75NTR) plays a crucial role in neurological diseases, but the role of p75NTR in PTSD is currently unknown. To investigate the effects and mechanisms of p75NTR in PTSD, in this study, a functional p75NTR-deficient mouse was used to establish a PTSD model by single prolonged stress (SPS) paradigm, then the behavioral effects and underlying mechanisms were further investigated. The results demonstrated that p75NTR deletion alleviated anxiety-like behavior and spatial learning and memory impairment in SPS-induced PTSD mice. Further study indicated that deletion of p75NTR downregulated the expression of apoptosis (Bax) and autophagy (Beclin-1) related proteins in the hippocampus of PTSD mice, protected against hippocampal neuronal damage, upregulated the expression of synaptic-related proteins (PSD95 and Synapsin I), increased dendritic complexity and dendritic spine density, and improved synaptic plasticity through the PI3K/Akt/mTOR pathway. In conclusion, deletion of p75NTR rescues behavioral and cognitive dysfunction through PI3K/Akt/mTOR pathway mediated regulation of hippocampal autophagy, apoptosis and synaptic plasticity in SPS-induced PTSD mice, which provides a potential therapeutic target for the treatment of PTSD.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"308 ","pages":"Article 142770"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in valorization of lignocellulosic waste into biochar and its functionalization for the removal of chromium ions. 木质纤维素废弃物转化为生物炭及其功能化去除铬离子的研究进展。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-01-11 DOI: 10.1016/j.ijbiomac.2025.139773

Jia Huang, Junfen Zhao, Jia Xu

{"title":"Recent advances in valorization of lignocellulosic waste into biochar and its functionalization for the removal of chromium ions.","authors":"Jia Huang, Junfen Zhao, Jia Xu","doi":"10.1016/j.ijbiomac.2025.139773","DOIUrl":"10.1016/j.ijbiomac.2025.139773","url":null,"abstract":"Lignocellulosic waste is a prevalent byproduct of agricultural and forestry activities which is an excellent feedstock for the preparation of biochar. This research area is of interest to the scientific community due to its potential in environmental remediation. In this regard, this review examines the latest advancements in transforming lignocellulosic waste into biochar and explores recent innovations in enhancing its functionality for chromium ion removal. It gives analysis on current methods for biochar production from lignocellulosic materials such as pyrolysis. Additionally focusing on improvements in production efficiency, structural properties, and surface modifications. The review also highlights various functionalization techniques, such as chemical activation and impregnation with metal oxides, that were innovated to improve adsorptive nature of biochar for chromium ions. While progress has been made, achieving scalability in lignocellulosic biochar production presents challenges, such as the high energy demands of pyrolysis, inconsistencies in feedstock quality, and the need for cost-effective functionalization methods. By summarizing recent research and technological progress, this paper aims to offer a clear perspective on the effectiveness of biochar derived from lignocellulosic waste in addressing contamination. Additionally, it discusses the ongoing challenges and future research directions needed to optimize biochar applications in environmental cleanup.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"139773"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanocarriers for cancer-targeted delivery based on Pickering emulsions stabilized by casein nanoparticles.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-02-08 DOI: 10.1016/j.ijbiomac.2025.140822

Avital Ella Ben-Haim, Nurit Shalev, Antolin Jesila Jesu Amalraj, Einat Zelinger, Karthik Ananth Mani, Eduard Belausov, Irit Shoval, Einat Nativ-Roth, Raquel Maria, Ayelet Atkins, Rajitha Sadashiva, Hinanit Koltai, Guy Mechrez

{"title":"Nanocarriers for cancer-targeted delivery based on Pickering emulsions stabilized by casein nanoparticles.","authors":"Avital Ella Ben-Haim, Nurit Shalev, Antolin Jesila Jesu Amalraj, Einat Zelinger, Karthik Ananth Mani, Eduard Belausov, Irit Shoval, Einat Nativ-Roth, Raquel Maria, Ayelet Atkins, Rajitha Sadashiva, Hinanit Koltai, Guy Mechrez","doi":"10.1016/j.ijbiomac.2025.140822","DOIUrl":"10.1016/j.ijbiomac.2025.140822","url":null,"abstract":"This study demonstrates the development of stimuli-responsive Pickering emulsions stabilized by casein nanoparticles (CNPs) for targeted drug delivery to colorectal cancer cells (CRC). Encapsulation of a fluorescent dye simulates therapeutic delivery, demonstrating biomedical potential. The oil-in-water nanoemulsions stabilized by CNPs function as nanocarriers sensitive to matrix metalloproteinase-7 (MMP-7), an enzyme overexpressed in CRC cells, enabling precise drug release. Emulsions exhibited strong stability due CNPs forming a robust layer at the oil-water interface, enhancing bioavailability and controlled release. Covalent modifications of CNPs with polyethyleneimine (PEI) or polyacrylic acid (PAA), and pH adjustments optimize the zeta potential, improving surface charge and delivery efficiency. Maximal CNP uptake occurred with PAA-modified CNPs (-20 mV), showing superior interaction with CRC cells compared to pristine (-6.7 mV) and PEI-modified (+30.5, +42.1 mV) CNPs. Confocal microscopy and imaging flow cytometry confirmed that CNP-stabilized emulsions enhance CRC inter-localization compared to dispersed CNPs. Nanoemulsions with the highest CNP uptake showed selective interaction with tumor cells, while minimizing oil droplet uptake, driven by nanoscale dimensions and targeted surface interactions. Enzymatic degradation of CNPs by MMP-7 induces phase separation and targeted release. This dual-functional system, leveraging charge modification and enzymatic responsiveness, highlights CNP-stabilized nanoemulsions as a promising CRC-targeted drug delivery platform.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"140822"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fucoidan from Apostichopus japonicus enhances intestinal barrier function and promotes intestinal immunity via regulating the gut microbiota and tryptophan metabolism. 褐藻糖聚糖通过调节肠道菌群和色氨酸代谢，增强肠道屏障功能，促进肠道免疫。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-01-16 DOI: 10.1016/j.ijbiomac.2025.139929

Wanting Qin, Biqian Wei, Pengfei Ren, Yaoguang Chang, Changhu Xue, Qingjuan Tang

{"title":"Fucoidan from Apostichopus japonicus enhances intestinal barrier function and promotes intestinal immunity via regulating the gut microbiota and tryptophan metabolism.","authors":"Wanting Qin, Biqian Wei, Pengfei Ren, Yaoguang Chang, Changhu Xue, Qingjuan Tang","doi":"10.1016/j.ijbiomac.2025.139929","DOIUrl":"10.1016/j.ijbiomac.2025.139929","url":null,"abstract":"Apostichopus japonicus is one of the most popular types of sea cucumber among consumers in Southeast Asia. Fucoidan from Apostichopus japonicus (Aj-FUC) has attracted considerable attention because of its immunomodulatory activities. Aj-FUC is indigestible in the human upper gastrointestinal tract but can be utilized by the gut microbiota. Thus, we suspect that Aj-FUC interacts with the gut to enhance immunefunction. This study showed that after a three-week intervention with Aj-FUC (100 mg/kg/d), the gut microbiota in mice developed a new homeostasis. Subsequently, in the condition of intestinal flora homeostasis, the effects of Aj-FUC on intestinal health in normal mice and the prevention of intestinal mucosal damage in cyclophosphamide-induced mice were investigated. Aj-FUC preserved intestinal structural integrity, increased the number of goblet cells, upregulated the expression of ZO-1 and Occludin, stimulated the secretion of sIgA and IgA, and maintained the Th1/Th2 balance. Importantly, beneficial bacteria were enriched, and tryptophan metabolism-related metabolites such as 5-hydroxyindole-3-acetic acid, and indole-3-lactic acid were upregulated following Aj-FUC administration. In summary, a three-week Aj-FUC intervention could result in the formation of a new homeostasis in intestinal flora, while the effect of Aj-FUC on intestinal immunity was related to the regulation of tryptophan metabolism by gut microbiota.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"139929"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biocatalytic enzymes in food packaging, biomedical, and biotechnological applications: A comprehensive review. 生物催化酶在食品包装、生物医学和生物技术中的应用：综述。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-01-18 DOI: 10.1016/j.ijbiomac.2025.140069

Palanisamy Vasudhevan, Zhang Ruoyu, Hui Ma, Subhav Singh, Deekshant Varshney, Shengyan Pu

引用次数: 0

Heterologous expression of a recombinant ACE inhibitory peptide LYPVK and its potential antihypertensive action mechanism.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-01-23 DOI: 10.1016/j.ijbiomac.2025.140274

Qingping Liang, Zhemin Liu, Menghao Xu, Jihai Zhu, Ziyu Liang, Changliang Zhu, Haijin Mou

{"title":"Heterologous expression of a recombinant ACE inhibitory peptide LYPVK and its potential antihypertensive action mechanism.","authors":"Qingping Liang, Zhemin Liu, Menghao Xu, Jihai Zhu, Ziyu Liang, Changliang Zhu, Haijin Mou","doi":"10.1016/j.ijbiomac.2025.140274","DOIUrl":"10.1016/j.ijbiomac.2025.140274","url":null,"abstract":"Enzymatic hydrolysis approach is commonly employed for preparation of active peptides, while the limited purity and yield of produced peptides hinder further development of action mechanisms. This study presents the biotechnological approach for the efficient production of recombinant angiotensin converting enzyme (ACE) inhibitory peptide LYPVK and investigates its potential antihypertensive action mechanism. DNA encoding sequence of recombinant peptide was designed to form in tandem, which was expressed in Escherichia coli BL21 (DE3). The expressed tandem repeat protein with molecular weight of 13.4 kDa was verified by high performance liquid chromatography (HPLC) and amino acid composition. Subsequently, LYPVK was generated following His-tag removal and trypsin-mediated cleavage of the purified protein, which was performed HPLC and liquid chromatography-mass spectrometry (LC-MS) analysis. LYPVK exhibited an IC50 value of 10.6 ± 0.86 μg/mL, demonstrating a non-competitive mode of action and resistance to gastrointestinal enzyme hydrolysis and heat conditions. Molecular docking results showed that LYPVK interacted with ACE through conventional hydrogen bonds and hydrophobic interactions. Except for ACE, ALB, SRC, PPARG, and MMP9 are identified as potential key targets for its antihypertensive activity by network pharmacological analysis. This study provides a promising biotechnological approach for the preparation of active peptides with high purity and yield.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"140274"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143035558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forsythoside B activates Siglec-14 to inhibit HIV-1 replication via the JAK1/STAT1 pathway.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-02-03 DOI: 10.1016/j.ijbiomac.2025.140632

Shanshan Chen, Xiaopeng Hu, Feirong Chen, Jie Liu, Jinming Su, Rongfeng Chen, Wudi Wei, Zongxiang Yuan, Sanqi An, Li Ye, Hao Liang, Junjun Jiang

{"title":"Forsythoside B activates Siglec-14 to inhibit HIV-1 replication via the JAK1/STAT1 pathway.","authors":"Shanshan Chen, Xiaopeng Hu, Feirong Chen, Jie Liu, Jinming Su, Rongfeng Chen, Wudi Wei, Zongxiang Yuan, Sanqi An, Li Ye, Hao Liang, Junjun Jiang","doi":"10.1016/j.ijbiomac.2025.140632","DOIUrl":"10.1016/j.ijbiomac.2025.140632","url":null,"abstract":"The HIV/AIDS epidemic poses a severe global health challenge. While antiretroviral therapy is crucial, it has limitations, including high costs and resistance, and requires long-term use. Consequently, novel antiviral agents with unique structures and innovative mechanisms are needed for better management of HIV/AIDS. We previously discovered that Siglec-14 inhibits HIV-1 replication. In this study, we employed homology modeling and AlphaFold 2 to predict the structure of Siglec-14, followed by molecular dynamics simulations to explore its conformational landscape. The MM/GBSA method was used to calculate the binding free energy of selected small molecules. Among them, Forsythoside B (FTS·B) exhibited the highest binding free energy and enhanced Siglec-14's conformational stability. SPR analysis further confirmed a strong binding affinity between FTS·B and Siglec-14. In vitro experiments demonstrated that FTS·B upregulates Siglec-14 expression and suppresses HIV-1 replication in macrophages. Mechanistically, FTS·B suppresses pro-inflammatory cytokines, increases the expression of interferon-stimulated genes and chemokines, and activates the JAK1/STAT1 pathway in Siglec-14 knockdown macrophages. Our results confirm that FTS·B, as an agonist of Siglec-14, effectively inhibits HIV-1 replication by upregulating Siglec-14 expression and modulating the JAK1/STAT1 signaling pathway, highlighting the potential clinical application value of FTS·B in HIV treatment.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"140632"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biorefinery of sugarcane molasses for poly(3-hydroxybutyrate) fermentation and genomic elucidation of metabolic mechanism using Paracoccus sp. P2.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-02-03 DOI: 10.1016/j.ijbiomac.2025.140684

Leizhen Zhao, Gaojie Sun, Mei Zhai, Shuai Zhao, Bin Ye, Jianghang Qu

{"title":"Biorefinery of sugarcane molasses for poly(3-hydroxybutyrate) fermentation and genomic elucidation of metabolic mechanism using Paracoccus sp. P2.","authors":"Leizhen Zhao, Gaojie Sun, Mei Zhai, Shuai Zhao, Bin Ye, Jianghang Qu","doi":"10.1016/j.ijbiomac.2025.140684","DOIUrl":"10.1016/j.ijbiomac.2025.140684","url":null,"abstract":"Biorefining sugarcane molasses to produce polyhydroxyalkanoates (PHAs) is an anticipated paradigm for replacing petroleum-based plastics. Nevertheless, there exists a deficiency in excellent chassis and genome resolution for the synthesis of poly(3-hydroxybutyrate) (PHB), which is a typical representative of PHAs. In this study, successive enrichment domestication was employed to screen PHB producers. The isolated species was defined as Paracoccus sp. P2 through taxonomic analysis. Then, a variety of nutrient substrates and physicochemical parameters were tailored to enhance the fermentation capacity. The maximum production of bio-polyester was 4.4 g·L-1, corresponding to a yield of 0.37 g-PHB·g-1-glucose. The concentration of PHB produced from 30 g·L-1 sugarcane molasses was 3.9 g·L-1, indicating a comparable fermentation performance. Furthermore, three-step condensation of acetyl-CoA and de novo synthesis of fatty acids were identified as the primary PHB accumulation pathways. The fermentation performance and genome investigation were compared with Paracoccus genus. The effective production of Paracoccus sp. P2 might be attributed to its efficient substrate conversion capacity and abundant PHB metabolic network. This study broadened the germplasm resources available for the bioconversion of sugarcane molasses, providing theoretical references for the valorization of high-concentration waste carbon sources.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"140684"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0