International Journal of Biological Macromolecules最新文献_第2页

Corrigendum to "Effects of acid hydrolysis intensity on the properties of starch/xanthan mixtures" [Int. J. Biol. Macromol. (Volume 106, 2018) Pages 320-329].

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-02 DOI: 10.1016/j.ijbiomac.2025.142608

Min Jiang, Yan Hong, Zhengbiao Gu, Li Cheng, Zhaofeng Li, Caiming Li

引用次数: 0

KLF12 transcriptional activation by a novel LncRNA A930015D03Rik enhances melanoma metastasis

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-02 DOI: 10.1016/j.ijbiomac.2025.142686

Meng Xiang , Ziyi Li , Jie Su , Xue Dai , Yuhan Zhang , Jiyu Tan , Xue Han , Jiacheng Xie , Yao Tang , Sicheng Zhang , Shimeng Guo , H. Rosie Xing , Jingyu Li , Jianyu Wang

{"title":"KLF12 transcriptional activation by a novel LncRNA A930015D03Rik enhances melanoma metastasis","authors":"Meng Xiang , Ziyi Li , Jie Su , Xue Dai , Yuhan Zhang , Jiyu Tan , Xue Han , Jiacheng Xie , Yao Tang , Sicheng Zhang , Shimeng Guo , H. Rosie Xing , Jingyu Li , Jianyu Wang","doi":"10.1016/j.ijbiomac.2025.142686","DOIUrl":"10.1016/j.ijbiomac.2025.142686","url":null,"abstract":"<div><div>Melanoma metastasis remains a poorly understood yet fatal hallmark of cancer progression, with limited therapeutic strategies targeting its underlying mechanisms. While the transcription factor KLF12 shows paradoxical roles across malignancies, its context-dependent functions in melanoma—particularly its regulatory interplay with extracellular vesicle (EV)-driven intercellular communication—have not been systematically explored. To address this gap, we investigated how metastatic melanoma cells exploit KLF12-mediated pathways through EV cargo transfer to propagate aggressive phenotypes. Our research results indicate that highly metastatic cells transfer lncRNA A930015D03Rik through exosomes, acting as a sponge for miR-204-5p, which promotes the expression of KLF12. The transcriptional activation of KLF12 facilitates the activation of critical pro-cancer pathways such as inflammation and NF-κB, while inhibiting the tumor-suppressive mechanisms of P53 and oxidative phosphorylation. This ultimately enhances the migration and invasion capabilities of low-metastatic tumor cells, driving the malignant progression of melanoma. In this study, we identified a novel tumor-derived EVs lncRNA, A930015D03Rik, which can enhance the expression of KLF12 through a ceRNA mechanism and influence the post-translational regulation of KLF12, thereby modulating the plasticity of tumor metastasis. This exosome-genome feedforward circuit explains KLF12's microenvironment-contingent pro-metastatic function, offering significant insights for the development of future therapeutic strategies targeting tumor metastasis.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"309 ","pages":"Article 142686"},"PeriodicalIF":7.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tailoring of agarose hydrogel to modulate its 3D bioprintability and mechanical properties for stem cell mediated bone tissue engineering

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-02 DOI: 10.1016/j.ijbiomac.2025.142795

Lakshmi M. Mukundan , Ragavi Rajasekaran , Samir Das , V.S. Seesala , Debabrata Ganguly , Nikhil Kumar , Santanu Dhara , Santanu Chattopadhyay

{"title":"Tailoring of agarose hydrogel to modulate its 3D bioprintability and mechanical properties for stem cell mediated bone tissue engineering","authors":"Lakshmi M. Mukundan , Ragavi Rajasekaran , Samir Das , V.S. Seesala , Debabrata Ganguly , Nikhil Kumar , Santanu Dhara , Santanu Chattopadhyay","doi":"10.1016/j.ijbiomac.2025.142795","DOIUrl":"10.1016/j.ijbiomac.2025.142795","url":null,"abstract":"<div><div>The intense gelling characteristics and viscosity constraints of agarose limit its utility as a sole ink material in 3D printing. This study presents the development of agarose bioink designed for cell-laden printing, featuring controlled printability, exceptional stiffness, and cell-responsiveness achieved via the insertion of photochemically reactive methacrylate groups. This chemical modification transforms the dense agarose network into a thinner structure, effecting a gentle thermogelling property that enhances the printability and facile cell encapsulation. Herein we examine the interplay between the degree of substitution and concentration variations to determine the optimal hydrogel composition. The best bioink composition possessed a lower shear modulus (storage modulus G' = 11.6 Pa) at 37 °C, assuring better bioprintability, while it possessed a Young's modulus of 1.4 ± 0.10 MPa in the crosslinked state, which is the highest reported in the natural single-matrix hydrogel systems. Studies with mesenchymal stem cells (MSC) confirmed that it is a good cell encapsulation matrix, achieving 111 % cell viability at 72 h. The bioprinted constructs promoted the osteogenic differentiation of MSC, as evidenced by mineralization and secretion of bone-related matrix. The gene expression analysis indicated that osteogenic marker expressions exhibited at least a two-fold increase on day 14 relative to the control group.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"309 ","pages":"Article 142795"},"PeriodicalIF":7.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation and comparison of the behavioral properties of raw, alkali-treated, and triethoxy silane–treated cellulosic fibers derived from Rottboellia cochinchinensis plant as a substantial material for polymer composites

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-02 DOI: 10.1016/j.ijbiomac.2025.142794

T. Ganapathy , D. Sundarrajan , S. Arivazhagan , P. Senthamaraikannan , Pandian Pitchipoo , S. Manoharan

{"title":"Evaluation and comparison of the behavioral properties of raw, alkali-treated, and triethoxy silane–treated cellulosic fibers derived from Rottboellia cochinchinensis plant as a substantial material for polymer composites","authors":"T. Ganapathy , D. Sundarrajan , S. Arivazhagan , P. Senthamaraikannan , Pandian Pitchipoo , S. Manoharan","doi":"10.1016/j.ijbiomac.2025.142794","DOIUrl":"10.1016/j.ijbiomac.2025.142794","url":null,"abstract":"<div><div>This investigation involved isolating a unique cellulosic fiber from the Raoul grass plant (<em>Rotboellia</em> cochinchinensis) and compared the behavioral effects of raw fiber with various chemical treatments, specifically 5 % NaOH and a 70: 30 mixture of (3-aminopropyl) triethoxy silane, on Raoul grass fiber. The treatments were conducted for 45 min, after which the fiber properties were evaluated. The cellulose percentages of the alkalized and silane-treated fibers increased to 72.29 % and 75.07 %, respectively, whereas the raw fiber contained 65.23 %. The X-ray diffraction study revealed a significant increase in the crystallinity index of the alkalized and silane-treated fibers, with an increase of 41.8 % and 43.89 %, compared to the 33.6 % found in the raw fiber. Thermogravimetric analysis established that both the alkalized and silane-treated fibers exhibited a maximum degradation peak at 366.27 °C. The kinetic activation energies for the alkalized and silane-treated fibers were 60.63 and 64.52 kJ/mol, respectively. The energy-dispersive spectroscopy spectrum of the alkalized and silane-treated Raoul grass fiber showed no impurity elements, indicating the successful elimination of impurities from the fiber's surface. These findings conclude that silane treatment is the most suitable method, and Raoul grass is a promising material for reinforcement in fiber-reinforced plastics.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"309 ","pages":"Article 142794"},"PeriodicalIF":7.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 3D bioprinted gelatin/quaternized chitosan/decellularized extracellular matrix based hybrid bionic scaffold with multifunctionality for infected full-thickness skin wound healing

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-02 DOI: 10.1016/j.ijbiomac.2025.142816

Jie Xu , Ya Su , Jiayi Yang , Hailin Ma , Huan Fang , Jingjing Zhu , Jiang Du , Yuen Yee Cheng , Yue Kang , Yiming Zhong , Bo Pan , Kedong Song

{"title":"A 3D bioprinted gelatin/quaternized chitosan/decellularized extracellular matrix based hybrid bionic scaffold with multifunctionality for infected full-thickness skin wound healing","authors":"Jie Xu , Ya Su , Jiayi Yang , Hailin Ma , Huan Fang , Jingjing Zhu , Jiang Du , Yuen Yee Cheng , Yue Kang , Yiming Zhong , Bo Pan , Kedong Song","doi":"10.1016/j.ijbiomac.2025.142816","DOIUrl":"10.1016/j.ijbiomac.2025.142816","url":null,"abstract":"<div><div>Skin wound repair, a highly integrated and overlapping process, is susceptible to infection, hyperoxia and excessive inflammation, which can delay wound healing or even lead to chronic wounds. In this study, a GQL/dGQue bilayered multifunctional scaffold, epidermis composed of gelatin (G), quaternized chitosan (Q) and lignin (L), and dermis composed of skin-derived decellularized extracellular matrix (d), gelatin and quercetin (Que), with bionic skin structure, was constructed by 3D bioprinting technology. The results showed that lignin effectively improved the mechanical properties (Young's modulus above 90 MPa) and regulated the appropriate degradation (about 84 % for 15 d) of the scaffold, as well as endowed it with good UV shielding properties. In addition, GQL/dGQue showed prominent antibacterial activity of 90.76 ± 4.94 % and 90.34 ± 4.14 % against <em>E. coli</em> and <em>S. aureus</em>, respectively, good free radical scavenging (87.22 ± 1.71 %) and significant anti-inflammatory properties. <em>In vivo</em> studies demonstrated that GQL/dGQue scaffold could effectively prevent wound infection and mitigate inflammation, thereby accelerating vascularization and regeneration of hair follicle and sebaceous gland with a remarkable wound closure of 98.29 ± 1.77 % at 21 d. Therefore, the GQL/dGQue bilayered multifunctional scaffold has a considerable potential to apply in skin tissue engineering for clinical wound repair.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"309 ","pages":"Article 142816"},"PeriodicalIF":7.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Immp2l gene knockout induces granulosa cell senescence by activation of cGAS-STING pathway via TFAM-mediated mtDNA leakage"[Int. J. Biol. Macromol. 307 (2025) 142368].

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-02 DOI: 10.1016/j.ijbiomac.2025.142619

Pengge Pan, Sinan Cao, Hui Gao, Xiaoya Qu, Yan Ma, Jinyi Yang, Xiuying Pei, Yanzhou Yang

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Corrigendum to "Anti-bacterial films developed by incorporating shikonin extracted from radix lithospermi and nano-ZnO into chitosan/polyvinyl alcohol for visual monitoring of shrimp freshness"[Int. J. Biol. Macromol. Volume 260, Part 2, March 2024, 129542].

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-02 DOI: 10.1016/j.ijbiomac.2025.142606

Jehangir Khan, Shah Alam, Teshale Ayano Begeno, Zhenxia Du

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High–strength, solvent–resistant carboxymethyl chitosan composite rubber based on dual covalent crosslinking network and hydrogen bond network for multi–functional sensing

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-02 DOI: 10.1016/j.ijbiomac.2025.142437

Wenyu Pan , Zequan Li , Fangyan Ou , Zhichao Zhang , Changsheng Wang , Ting Xie , Chuang Ning , Riyao Cong , Xuehan Gao , Zhiyong Qin , Zengxi Wei , Qian Sun , Wei Gao , Yan Qing , Shuangliang Zhao

{"title":"High–strength, solvent–resistant carboxymethyl chitosan composite rubber based on dual covalent crosslinking network and hydrogen bond network for multi–functional sensing","authors":"Wenyu Pan , Zequan Li , Fangyan Ou , Zhichao Zhang , Changsheng Wang , Ting Xie , Chuang Ning , Riyao Cong , Xuehan Gao , Zhiyong Qin , Zengxi Wei , Qian Sun , Wei Gao , Yan Qing , Shuangliang Zhao","doi":"10.1016/j.ijbiomac.2025.142437","DOIUrl":"10.1016/j.ijbiomac.2025.142437","url":null,"abstract":"<div><div>In order to prepare natural polymer composite rubber with excellent mechanical properties, solvent resistance and electrical conductivity, and to apply it to multifunctional sensing. In this study, an environmentally friendly and effective strategy was employed to solve these problems. Carboxymethyl chitosan composite rubber was prepared by introducing the dual covalent crosslinking network into carboxy nitrile butadiene rubber via amide and radical reactions, followed by blending with carboxymethyl chitosan to introduce a hydrogen bonding network. The tensile strength of the prepared composite rubber was increased by 45 times, the crosslink density was increased by 405 times, the mechanical properties and solvent resistance were significantly improved, and the electrical conductivity was also obtained. Based on these excellent properties, carboxymethyl chitosan composite rubber can be used in strain sensors to detect human movement, and realize information encryption; it can also be used in humidity sensors to detect human respiration, environmental humidity and industrial pipeline safety. The nature polymer composite rubber prepared in this work will have great potential for application in flexible electronic devices.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"309 ","pages":"Article 142437"},"PeriodicalIF":7.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Near-infrared light-triggered silk fibroin hydrogels integrated with polydopamine-modified nanoparticles for enhanced wound healing and infection control

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-02 DOI: 10.1016/j.ijbiomac.2025.142814

Shaorong Yan , Zhenxin Yu , Haomin Yang , Yongqiang Yang , Jien Qin , Xiaochen Wu , Gaoyang Lin

{"title":"Near-infrared light-triggered silk fibroin hydrogels integrated with polydopamine-modified nanoparticles for enhanced wound healing and infection control","authors":"Shaorong Yan , Zhenxin Yu , Haomin Yang , Yongqiang Yang , Jien Qin , Xiaochen Wu , Gaoyang Lin","doi":"10.1016/j.ijbiomac.2025.142814","DOIUrl":"10.1016/j.ijbiomac.2025.142814","url":null,"abstract":"<div><div>This study presents the development and evaluation of a novel silk fibroin (SF)-based hydrogel composite, SiPDA/Ag-C, enhanced with polydopamine (PDA)-modified silver nanoparticles (Ag@PDA) and PDA-modified curcumin (Cur-PDA), for skin wounds treatment and infection control. Dopamine readily oxidizes and reacts with SF to form hydrogels. By <em>in-situ</em> synthesizing silver nanoparticles (Ag NPs) on the surface of PDA nanospheres, Ag@PDA achieves a dual antibacterial effect. It combines the photothermal antibacterial property of PDA with the ability of Ag NPs to disrupt bacterial membranes and DNA. Coating PDA on the surface of curcumin creates Cur-PDA nanoparticles, which not only enhance curcumin's bioavailability but also integrate curcumin's anti-inflammatory and antioxidant properties with PDA's antioxidant and photothermal antibacterial capabilities. Combining Ag@PDA and Cur-PDA into the SF hydrogel matrix results in the SiPDA/Ag-C hydrogel. The hydrogel leverages the photothermal properties of PDA to achieve non-invasive wound healing under near-infrared (NIR) light irradiation. The SiPDA/Ag-C hydrogel could significantly inhibit the growth of <em>Staphylococcus aureus</em> and <em>Escherichia coli in vitro</em> and <em>in vivo</em>, and promote wound healing by reducing inflammation, enhancing antioxidant capacity, and stimulating tissue regeneration. <em>In vivo</em> study shows that compare with the treatment of SiPDA/Ag-C hydrogel alone, the combined treatment with NIR irradiation could significantly inhibit bacterial growth and improve tissue repair. The hydrogel also exhibited excellent biocompatibility, biodegradability, and minimal cytotoxic effects, making it a promising candidate for advanced wound care and tissue engineering applications.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"309 ","pages":"Article 142814"},"PeriodicalIF":7.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Development and characterization of starch/PVA antimicrobial active films with controlled release property by utilizing electrostatic interactions between nanocellulose and lauroyl arginate ethyl ester"[Int. J. Biol. Macromol. 261 (2024) 129415].

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-02 DOI: 10.1016/j.ijbiomac.2025.142624

Junxiao Qiao, Yiyan Dong, Chenwei Chen, Jing Xie

引用次数: 0