International Journal of Biological Macromolecules最新文献_第2页

Phosphate carboxymethyl cellulose nanocomposites with ketoconazole from eggshell waste as a drug delivery platform for odontology application 蛋壳废弃物中磷酸羧甲基纤维素-酮康唑纳米复合材料在口腔医学中的应用

IF 8.5 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-10-10 DOI: 10.1016/j.ijbiomac.2025.148157

Jhonatan do Amparo Madureira , Micheli de Souza Bernardes , Shakeel Abbas , Silas Silva Santana , Fernanda G.L. Medeiros Borsagli

{"title":"Phosphate carboxymethyl cellulose nanocomposites with ketoconazole from eggshell waste as a drug delivery platform for odontology application","authors":"Jhonatan do Amparo Madureira , Micheli de Souza Bernardes , Shakeel Abbas , Silas Silva Santana , Fernanda G.L. Medeiros Borsagli","doi":"10.1016/j.ijbiomac.2025.148157","DOIUrl":"10.1016/j.ijbiomac.2025.148157","url":null,"abstract":"<div><div>Nowadays, producing an innovative platform for a controlled drug delivery system using agroindustry waste is a great opportunity for the sustainable, economic, and developed world. Thus, this research produced innovative nanocomposites based on the production of phosphate nanoparticles by the co-precipitation method on carboxymethyl cellulose (CMC) using eggshell and incorporating ketoconazole to combat Candida albicans in odontology treatments. Then, Raman, XRD, and SEM analyses were used to characterize these nanocomposites. Additionally, the kinetics of drug release were studied, including antimicrobial activity and cell viability. The results showed that effective nanocomposites with hydroxyapatite (HA) nanoparticles incorporated with a size close to 20 nm, modified by ketoconazole, were produced. Moreover, the ketoconazole does not affect the morphological and crystalline structure of the nanocomposite, and the CMC enhances its antimicrobial activity. Furthermore, all samples presented biocompatibility, as no cytotoxicity was visualized (≥85 %). Thus, these results showed that these nanocomposites possess a high potential for application in endodontic and periodontic treatment in odontology applications.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"330 ","pages":"Article 148157"},"PeriodicalIF":8.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145264133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication, characterization, and physicochemical properties of curcumin incorporated new P. vulgaris polysaccharides bio-composite film; potent drug carrier, antibacterial, and antioxidant properties. 姜黄素含新姜黄多糖生物复合膜的制备、表征及理化性能研究有效的药物载体，抗菌和抗氧化性能。

IF 8.5 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-10-10 DOI: 10.1016/j.ijbiomac.2025.148165

Divya Bharathi Jothinathan, S R Suseem

{"title":"Fabrication, characterization, and physicochemical properties of curcumin incorporated new P. vulgaris polysaccharides bio-composite film; potent drug carrier, antibacterial, and antioxidant properties.","authors":"Divya Bharathi Jothinathan, S R Suseem","doi":"10.1016/j.ijbiomac.2025.148165","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.148165","url":null,"abstract":"This study reports the fabrication and comprehensive evaluation of bio-composite films derived from Phaseolus vulgaris starch and cellulose, incorporating curcumin via solvent casting method. Structural characterization using UV-Vis, FT-IR, and XRD confirmed curcumin encapsulation and revealed modifications in crystallinity, with 13C MAS NMR confirming the preservation of cellulose I and A-type starch polymorphs. SEM and AFM analyses displayed homogenous film morphology and enhanced polymer drug compatibility. Mechanical strength improved with curcumin content, increasing from 17.99 MPa (neat St) to 32.12 MPa for St/Ce/Cur - 13 % curcumin film. All the films exhibited uniform thicknesses. Porosity rose from 25.13 ± 0.12 % (neat St) to 39.2 ± 0.21 % (13 %), while WVTR increased from 679.5 ± 3.1 g/m-2d-1 to 1049.4 ± 3.1 g/m-2d-1. Water absorption increased from 52.6 ± 1.24 % to 90.4 ± 0.64 %, and contact angle values rose from 5.8° to 29.4°, indicating higher hydrophobicity. The St/Ce/Cur - 13 % film exhibited the highest drug loading (2.11 ± 0.02 %) and encapsulation efficiency (94.3 ± 0.081 %). Drug release studies (0-72 h in PBS) showed 96 % sustained and slow release for St/Ce/Cur - 13 %, best described by a first-order model (R2 = 0.8914). DPPH assay results revealed strong antioxidant capacity with an IC₅₀ of 181.04 μg/mL for the St/Ce/Cur - 13 % film. Antibacterial tests indicated inhibition zones of 11 mm (S. aureus), 9 mm (B. subtilis), and 7 mm (E. coli) for the St/Ce/Cur - 13 % formulation. The results suggest P. vulgaris based polysaccharides as a sustainable matrix for drug delivery systems with wound healing potential.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"148165"},"PeriodicalIF":8.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145278523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermo-hydration driven shape-memory hydrogel with functional cellulose for smart vascular stent. 含功能纤维素的热水合驱动形状记忆水凝胶用于智能血管支架。

IF 8.5 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-10-10 DOI: 10.1016/j.ijbiomac.2025.148238

Yulei Li, Guohua Miao, Cuiping Wang, Sheng Chen, Chunli Yao, Yanglei Xu, Feng Xu

{"title":"Thermo-hydration driven shape-memory hydrogel with functional cellulose for smart vascular stent.","authors":"Yulei Li, Guohua Miao, Cuiping Wang, Sheng Chen, Chunli Yao, Yanglei Xu, Feng Xu","doi":"10.1016/j.ijbiomac.2025.148238","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.148238","url":null,"abstract":"Vascular stents fabricated from shape memory polymers (SMPs) are gaining increasing attention as a potential solution for arterial diseases. The primary challenge lies in constructing SMPs that respond at physiological temperature (37 °C). Considering water's modulation effect on intermolecular forces, we expect to develop a physiological temperature responsive SMP that triggers shape shifting from temporary shape to permanent shape in thermo-hydration environments (37 °C). To achieve this objective, we synthesize a waterborne polyurethane/cellulose nanocrystal composite (WPCx, where x represents wt% of CNC relative to WPU) through solvent-assisted self-assembly of waterborne polyurethane (WPU) with uniformly dispersed cellulose nanocrystals (CNCs) as reinforcing fillers. Molecular dynamics simulations reveal that CNC-WPU interfacial interactions convert cohesive chain attraction into steric repulsion under thermo-hydration conditions, enabling programmable shape recovery at 37 °C with 95.2 % efficiency. Crucially, CNC dispersion reduces surface energy, accelerating water diffusion kinetics, and enhancing hydrophilicity. Due to the superior shape memory capabilities, mechanical properties, biocompatibility and effective drug release, WPCx can be used not only to prepare stents but also to guide the exploration of potential applications of SMPs.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"148238"},"PeriodicalIF":8.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145278560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chirality-induced dual self-healing chitosan-based coating on titanium surface for corrosion protection. 手性诱导双自愈壳聚糖基钛表面防腐涂层。

IF 8.5 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-10-10 DOI: 10.1016/j.ijbiomac.2025.148212

Yangyang Duan, You Wu, Juan Qiu, Houyi Ma

{"title":"Chirality-induced dual self-healing chitosan-based coating on titanium surface for corrosion protection.","authors":"Yangyang Duan, You Wu, Juan Qiu, Houyi Ma","doi":"10.1016/j.ijbiomac.2025.148212","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.148212","url":null,"abstract":"The development of self-healing anti-corrosion coatings has recently garnered significant attention as an efficient strategy for preventing substrate corrosion and prolonging substrate service life. Herein, we develop a chirality-induced dual self-healing coating through pH-responsive tryptophan isomers-loaded halloysite nanotubes (L/D-Trp@HNTs) imbedded into chitosan (CHI) coatings. Results showed that the L/D-Trp@HNTs/CHI coating exhibited an excellent self-healing behavior, which can originate from the release of L/D-Trp from the HNTs nanocontainers. The protection effect of the coating was effectively enhanced by two approaches. First, L-Trp could be released from the HNTs and then mainly permeates through the CHI coating, forming a protective film on the metal surface. Second, D-Trp released from the nanocontainers could be captured by the CHI coating through the formation of H-bonds, significantly increasing the crosslinking density of the CHI coating and reducing defects in the CHI coating. This natural polysaccharide CHI-based chiral system could open a new avenue toward corrosion protection applications.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"148212"},"PeriodicalIF":8.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145278575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activin B participates in ovarian development in Japanese eel (Anguilla japonica) via coordinated regulation of reproductive signaling and metabolic pathways. 激活素B通过协调调节生殖信号和代谢途径参与日本鳗鲡卵巢发育。

IF 8.5 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-10-10 DOI: 10.1016/j.ijbiomac.2025.148149

Chenpeng Zuo, Xuanhan Zhang, Xiao Jing, Yuting Ci, Ziyi Zhao, Ming Liu, Yun Li, Haishen Wen, Xin Qi

{"title":"Activin B participates in ovarian development in Japanese eel (Anguilla japonica) via coordinated regulation of reproductive signaling and metabolic pathways.","authors":"Chenpeng Zuo, Xuanhan Zhang, Xiao Jing, Yuting Ci, Ziyi Zhao, Ming Liu, Yun Li, Haishen Wen, Xin Qi","doi":"10.1016/j.ijbiomac.2025.148149","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.148149","url":null,"abstract":"The Japanese eel (Anguilla japonica) is a commercially valuable catadromous species widely cultured in East Asia. However, large-scale artificial propagation remains challenging. Activin B, a dimeric protein belonging to the transforming growth factor-β (TGF-β) superfamily, plays key roles in vertebrate gonadal development, yet its function in eel ovarian development has not been characterized. In this study, we cloned the inhbb gene from Japanese eel, expressed its recombinant Activin B protein, and evaluated its effects on ovarian development under artificial induction conditions. Adult females induced into vitellogenesis with human chorionic gonadotropin (hCG) were administered recombinant Activin B or saline for eight weeks. Integrated analyses combining serum hormone measurements, transcriptomics, and untargeted metabolomics revealed that Activin B significantly elevated estradiol levels and regulated multiple reproductive signaling pathways-including Smad, MAPK, GnRH, insulin, VEGF, and FoxO-as well as key metabolic processes related to steroid, lipid, and amino acid metabolism. These findings highlight the endocrine-metabolic coordination of Activin B in ovarian development, which could offer a theoretical basis for artificial reproduction in Japanese eel.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"148149"},"PeriodicalIF":8.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145278583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pan-genome analysis of the LATERAL ORGAN BOUNDARIES domain family in camelina and function investigation of LATERAL ORGAN BOUNDARIES domain 40 in fatty acid synthesis. 亚麻荠侧器官边界结构域家族的泛基因组分析及侧器官边界结构域40在脂肪酸合成中的功能研究。

IF 8.5 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-10-10 DOI: 10.1016/j.ijbiomac.2025.148232

Pengfang Qiao, Noor Saleem, Jialiang Zhao, Cuizhu Zhao, Meng Zhang

{"title":"Pan-genome analysis of the LATERAL ORGAN BOUNDARIES domain family in camelina and function investigation of LATERAL ORGAN BOUNDARIES domain 40 in fatty acid synthesis.","authors":"Pengfang Qiao, Noor Saleem, Jialiang Zhao, Cuizhu Zhao, Meng Zhang","doi":"10.1016/j.ijbiomac.2025.148232","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.148232","url":null,"abstract":"Camelina (Camelina sativa (L.) Crantz) is an allohexaploid oilseed crop with a cultivation history of about six thousand years, yet its pan-genome was poorly studied. Moreover, Lateral Organ Boundary Domain (LBD) transcription factor family remains uninvestigated. Here, we performed a pan-genome analysis of LBD genes across 13 camelina accessions, identifying 1487 members classified into 44 Core, 2 SoftCore, 15 Dispensable, and 21 Private orthologous groups. Camelina LBDs were classified into Class I (six subclasses) and Class II (two subclasses). Selection pressure analysis showed that compared with Core LBD genes and SoftCore genes, Dispensable genes have undergone obvious relaxed selection. Promoter analysis identified subclass-specific regulatory elements, with Class IIB significantly enriched in endosperm-specific expression motifs and Class IA1 associated with stress responses. Transcriptome profiling revealed some tissue-specific expression patterns, including potential roles of LBD40/41 in seed development. Functional validation demonstrated that AtLBD40 overexpression in Arabidopsis and camelina remodeled fatty acid composition by suppressing FAD3 and KCS18, thereby reducing the relative contents of 18:3 and 22:1. Arabidopsis lbd40-1 and lbd40-2 mutant analyses suggested a possible functional redundancy between LBD40 and LBD41. This study elucidates the dynamic evolution of the camelina LBD family and its pivotal role in regulating the fatty acid profile in seeds, establishing a foundation for targeted oil quality improvement in this versatile crop.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"148232"},"PeriodicalIF":8.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145278529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amino acid-based flame retardants for textiles: Recent advances in properties and synthesis methods: A review. 纺织品用氨基酸基阻燃剂：性能和合成方法的最新进展

IF 8.5 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-10-10 DOI: 10.1016/j.ijbiomac.2025.148242

Betina Małysa, Katarzyna Zielińska, Tomasz Krawczyk

{"title":"Amino acid-based flame retardants for textiles: Recent advances in properties and synthesis methods: A review.","authors":"Betina Małysa, Katarzyna Zielińska, Tomasz Krawczyk","doi":"10.1016/j.ijbiomac.2025.148242","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.148242","url":null,"abstract":"Textiles, both natural and synthetic, are essential in clothing and industrial applications but are inherently flammable, requiring effective flame-retardant (FR) treatments. Conventional FRs, particularly halogen- and phosphorus-based systems, raise concerns regarding health and environmental impacts. Amino acids, available from natural sources or industrial byproducts, represent a sustainable alternative due to their renewability, biodegradability, and chemical versatility. This review provides a comprehensive assessment of amino acid-based FRs for textiles, integrating studies published between 2010 and 2025. It examines synthesis strategies such as phosphorylation, Mannich reactions, and polyamidoamine formation; evaluates application methods across substrates including cotton, polyester, and Lyocell; and analyzes fire performance using metrics such as Limiting Oxygen Index, Peak Heat Release Rate, and Total Heat Release. Environmental and economic considerations, mechanisms of action, and durability of treatments are also discussed. By consolidating quantitative performance data and classifying approaches, this work addresses gaps in previous reviews and highlights opportunities for further development of amino acid-based FRs as promising candidates for safer, sustainable protection in textiles used in clothing, automotive, and filtration applications.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"148242"},"PeriodicalIF":8.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145278545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-pot enzyme cascade production of therapeutic deoxyribonucleoside analogs from glycerol and acetaldehyde. 用甘油和乙醛一锅酶级联生产治疗性脱氧核糖核苷类似物。

IF 8.5 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-10-10 DOI: 10.1016/j.ijbiomac.2025.148250

Ja Hyun Lee, Yoonjoo Kim, Dong Hyun Kim, Kyoung Heon Kim

{"title":"One-pot enzyme cascade production of therapeutic deoxyribonucleoside analogs from glycerol and acetaldehyde.","authors":"Ja Hyun Lee, Yoonjoo Kim, Dong Hyun Kim, Kyoung Heon Kim","doi":"10.1016/j.ijbiomac.2025.148250","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.148250","url":null,"abstract":"In this study, we demonstrated a novel one-pot enzyme cascade for the production of deoxyribonucleoside analogs using glycerol and acetaldehyde (AcH) as starting materials. In the initial stage of the cascade, 2-deoxy-d-ribose 5-phosphate (D-dRib 5P) was generated in situ from glycerol via a non-hydrolytic aldol addition between D-glyceraldehyde 3-phosphate (D-GAP) and AcH, catalyzed by aldolase. D-dRib 5P was subsequently converted into target deoxyribonucleosides through a retrosynthetic enzyme cascade that effectively reverses the natural deoxyribonucleoside salvage pathway, with the choice of nucleobases and nucleoside phosphorylases determining the final products. A key limitation-yield reduction due to the accumulation of free hydrogen phosphate (HPO₄2-)-was strategically addressed by modulating HPO₄2- levels through a free HPO₄2--scavenging system employing sucrose phosphorylase and excess sucrose. Using this approach, we successfully synthesized four commercially relevant therapeutic deoxyribonucleosides-floxuridine, idoxuridine, decitabine, and cladribine-by varying the nucleobases and nucleoside phosphorylases. These findings highlight the potential of this biocatalytic platform for the sustainable and cost-effective production of deoxyribonucleoside analogs from simple, renewable feedstocks.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"148250"},"PeriodicalIF":8.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145278580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural characterization of an active fructan from Atractylodes lancea rhizome and evaluation of its hypoglycemic and adjunctive hypoglycemic effects. 苍术活性果聚糖的结构表征及其降糖和辅助降糖作用的评价。

IF 8.5 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-10-10 DOI: 10.1016/j.ijbiomac.2025.148257

Xiaozhen Wang, Weiyi Zhao, Xia Li, Lanping Guo, Wenyuan Gao

{"title":"Structural characterization of an active fructan from Atractylodes lancea rhizome and evaluation of its hypoglycemic and adjunctive hypoglycemic effects.","authors":"Xiaozhen Wang, Weiyi Zhao, Xia Li, Lanping Guo, Wenyuan Gao","doi":"10.1016/j.ijbiomac.2025.148257","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.148257","url":null,"abstract":"Superior biodegradability and biocompatibility have established natural polysaccharides as increasingly prominent materials in biomedical and food applications. A growing number of plant-derived polysaccharides with the ability to regulate glycolipid metabolism or assist in hypoglycemic functions have been identified and studied. In this work, ALP-1 was extracted and purified from the dried rhizomes of Atractylodes lancea (Thunb.) DC. Structural analysis revealed that ALP-1, with a molecular weight of 5072 Da, is primarily a neutral polysaccharide consisting of fructose and glucose at a molar ratio of 94.77 %: 5.23 %. It was characterized as a fructan featuring Glcp- (1→, →1) -Fruf- (2 → and Fruf- (2 → linkages as the backbone. ALP-1 demonstrated favorable regulatory effects on glucolipid metabolism both in vitro and in vivo. In addition, the combination of ALP-1 with a low dose of metformin (LMET, 100 mg/kg) effectively promoted glucose consumption and glycogen synthesis in IR-HepG2, achieving comparable efficacy to metformin alone. In diabetic mice, the LMET-ALP-1 combination likewise yielded hypoglycemic outcomes equivalent to metformin monotherapy, as evidenced by enhanced glucose tolerance, improved serum lipid metabolism, attenuated hepatic steatosis, and recovery of pancreatic islet function. These findings indicate that ALP-1 has potential as a functional component for regulating glycolipid metabolism and may serve as an adjunctive therapy to metformin for hypoglycemic applications in the future.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"148257"},"PeriodicalIF":8.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145278553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triethylenetetramine functionalized tannic acid/sodium alginate composite aerogel and its adsorption performance of Cu²⁺ and Pb²^. 三乙烯四胺功能化单宁酸/海藻酸钠复合气凝胶及其对Cu2+和Pb2的吸附性能。

IF 8.5 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-10-10 DOI: 10.1016/j.ijbiomac.2025.148181

Hai Li, Xing Wang, Shilu Zhang, Chongju Mu, Faguo Li, Wei Wang, Fengwei Shi, Jianglei Hu

{"title":"Triethylenetetramine functionalized tannic acid/sodium alginate composite aerogel and its adsorption performance of Cu2+ and Pb2.","authors":"Hai Li, Xing Wang, Shilu Zhang, Chongju Mu, Faguo Li, Wei Wang, Fengwei Shi, Jianglei Hu","doi":"10.1016/j.ijbiomac.2025.148181","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.148181","url":null,"abstract":"Heavy metal pollution in water could lead to a major hazard to human health and environmental integrity, which necessitates the urgent development of effective remediation strategies for removing poisonous heavy metals from wastewater. A new dual-network aerogel adsorbent (STT) was fabricated using modified tannic acid (TA) and sodium alginate (SA) to remove Cu2+ and Pb2+ from water. The influence of various factors on the adsorption process of STT was investigated. Results indicated that, compared with calcium alginate (CA) aerogel, the mechanical property of STT aerogel was enhanced to 14.0 kg·cm-2. The maximum capacities of adsorption for Cu2+ and Pb2+ could reach 304.30 mg·g-1 and 422.80 mg·g-1, respectively. After 10 regeneration cycles, STT maintained the adsorption rates of 84.58 % for Cu2+ and 87.89 % for Pb2+. Analysis of kinetic, thermodynamic, and isothermal adsorption models suggested that the adsorption mechanism involved a spontaneous monolayer chemisorption process. The adsorption mechanism of STT was investigated using XPS and FT-IR, illustrating the adsorption of Cu2+ and Pb2+ by STT occurred through ion exchange and complexation processes. The STT adsorbent, in general, demonstrated promising potential as a heavy metal adsorbent.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"148181"},"PeriodicalIF":8.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145278597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0