International Journal of Biological Macromolecules最新文献_第2页

Mitochondrial oxidative stress related LncRNA predict cervical cancer prognosis and immunotherapy response: Molecular structure and protein interaction of ribosomal protein L34.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-01-20 DOI: 10.1016/j.ijbiomac.2025.140145

Nanchang Wu, Fengjuan Lin, Jianying Ji, Hongxia Pan, Lingyuan Xiang, Guanxiu Xian, Shengcai Chen

{"title":"Mitochondrial oxidative stress related LncRNA predict cervical cancer prognosis and immunotherapy response: Molecular structure and protein interaction of ribosomal protein L34.","authors":"Nanchang Wu, Fengjuan Lin, Jianying Ji, Hongxia Pan, Lingyuan Xiang, Guanxiu Xian, Shengcai Chen","doi":"10.1016/j.ijbiomac.2025.140145","DOIUrl":"10.1016/j.ijbiomac.2025.140145","url":null,"abstract":"The purpose of this study was to investigate the predictive value of mitochondrial oxidative stress-related LncRNA in cancer prognosis and immunotherapy response, and to further analyze the molecular structure of ribosomal protein L34 and its interaction mechanism with the protein. We screened lncrnas associated with mitochondrial oxidative stress, evaluated their expression patterns in different cancer types, and analyzed the three-dimensional structure of ribosomal protein L34 and its interaction network with other proteins. In this study, public databases were used to screen out lncrnas associated with mitochondrial oxidative stress. Bioinformatic analysis, including gene expression profile analysis, survival analysis and functional enrichment analysis, was used to evaluate the expression patterns of these lncrnas in different cancer types and their relationship with prognosis. The interacting proteins of ribosomal protein L34 were identified by proteomic techniques. The three-dimensional structure of ribosomal protein L34 and its binding mode with interacting proteins were studied by molecular docking and dynamic simulation methods. The results showed that the screened lncrnas showed significant expression differences in multiple cancer types and were closely related to the survival rate of patients. The three-dimensional structure of ribosomal protein L34 reveals key amino acid residues and binding sites for its interactions with specific proteins. Functional enrichment analysis showed that these lncrnas may affect the development of cancer through regulating oxidative stress response, cell cycle and apoptosis. The interaction network of ribosomal protein L34 reveals its central role in protein synthesis and cellular stress response.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"140145"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive peptides with antioxidant and ACE inhibitory properties in goat milk protein hydrolysates: Peptidomics and molecular docking study.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-01-23 DOI: 10.1016/j.ijbiomac.2025.140286

Wenhua Zhang, Mohamed Aamer Abubaker, Zekun Li, Yu He, Qin Shu, Linqiang Li, Yongfeng Liu

引用次数: 0

Structural characteristics of linear dextrin and in vitro digestion of lauric acid complexes generated via gradient alcohol precipitation.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-01-22 DOI: 10.1016/j.ijbiomac.2025.140231

Yuqing Hu, Chengyi Sun, Caihong Wang, Liping Mei, Zhaoxian He, Yajie Chen, Yanyan Liu, Guangli Luo, Li Guo, Xu Chen, Xianfeng Du

{"title":"Structural characteristics of linear dextrin and in vitro digestion of lauric acid complexes generated via gradient alcohol precipitation.","authors":"Yuqing Hu, Chengyi Sun, Caihong Wang, Liping Mei, Zhaoxian He, Yajie Chen, Yanyan Liu, Guangli Luo, Li Guo, Xu Chen, Xianfeng Du","doi":"10.1016/j.ijbiomac.2025.140231","DOIUrl":"10.1016/j.ijbiomac.2025.140231","url":null,"abstract":"Linear dextrin (LD), a low-molecular-weight carbohydrate, regarded as a type of short amylose, can form resistant starch when combined with fatty acids. This study investigated the structural properties and in vitro digestion of linear dextrins and their complexes with lauric acid (LA). Four groups of linear dextrins were prepared by pretreating gelatinized high-amylose maize starch (HAMS) with pullulanase followed by gradient ethanol precipitation at concentrations of 0 %, 50 %, 60 %, and 70 % (v/v). The GPC results showed that the weight average molecular weight (Mw) of these linear dextrins were 425.88 kDa, 189.68 kDa, 3.77 kDa and 2.01 kDa, respectively. After linear dextrins were complexed with lauric acid through co-precipitation treatment, the X-ray diffraction data revealed that, except for LD-70-LA, all other complexes formed a V-type structure. The complexing index of the complexes initially increased and then declined with increasing ethanol concentration, reaching a peak value of 41.54 % for LD-50-LA. The LD-0-LA, LD-60-LA and LD-70-LA complexes exhibited weaker anti-digestion properties compared to LD-50-LA, which demonstrated the highest resistant starch content at 52.43 %. This study offers a new approach and application potential for the efficient production of resistant starch.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"140231"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143035437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile and atom-economical synthesis of highly efficient chitosan-based flame retardants towards fire-retarding and antibacterial multifunctional coatings on cotton fabrics.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-01-22 DOI: 10.1016/j.ijbiomac.2025.140205

Xing Cao, Yuan-Yuan Huang, Xin-Yu Tian, Yan-Peng Ni, Yu-Zhong Wang

{"title":"Facile and atom-economical synthesis of highly efficient chitosan-based flame retardants towards fire-retarding and antibacterial multifunctional coatings on cotton fabrics.","authors":"Xing Cao, Yuan-Yuan Huang, Xin-Yu Tian, Yan-Peng Ni, Yu-Zhong Wang","doi":"10.1016/j.ijbiomac.2025.140205","DOIUrl":"10.1016/j.ijbiomac.2025.140205","url":null,"abstract":"The development of bio-based flame retardants has garnered significant attention, however, significant challenges remain in achieving efficient flame retardancy and eco-friendly preparation methods. Herein, we propose a facile, atomic-efficient, and eco-friendly strategy for synthesizing a trinity chitosan-based flame retardant, phosphite-protonated chitosan (PCS). The chemical structure was systematically analyzed and the impact of varying degrees of protonation on the dissolution behavior and rheological properties were investigated. Benefiting from the promotion of dehydration and carbonization facilitated by phosphite groups, PCS exhibits high intrinsic flame retardancy with an LOI value of 80.7 %. Moreover, its favorable rheological and film-forming properties make it well-suited for easy application as a multifunctional coating in fabric finishing through blade coating processes. The finished cotton and polyester/cotton blended fabrics exhibit excellent flame retardancy, as evidenced by increased LOI values, successful passage of vertical burning tests, reductions of up to 65.0 % and 50.3 % in pHRR and THR values, respectively. Additionally, PCS imparts superior antibacterial properties to the fabrics, achieving a 99.99 % antibacterial rate against both E. coli and S. aureus. This study introduces a straightforward and atom-economical approach for preparing highly efficient chitosan-based flame retardants, along with the development of a transparent, green, and efficacious multifunctional coating system on textiles.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"140205"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143035525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptide-modified nanoparticles for doxorubicin delivery: Strategies to overcome chemoresistance and perspectives on carbohydrate polymers.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-01-22 DOI: 10.1016/j.ijbiomac.2025.140143

Xu Han, Xue Zhang, Longdan Kang, Shuai Feng, Yinyan Li, Ge Zhao

{"title":"Peptide-modified nanoparticles for doxorubicin delivery: Strategies to overcome chemoresistance and perspectives on carbohydrate polymers.","authors":"Xu Han, Xue Zhang, Longdan Kang, Shuai Feng, Yinyan Li, Ge Zhao","doi":"10.1016/j.ijbiomac.2025.140143","DOIUrl":"10.1016/j.ijbiomac.2025.140143","url":null,"abstract":"Chemotherapy serves as the primary treatment for cancers, facing challenges due to the emergence of drug resistance. Combination therapy has been developed to combat cancer drug resistance, yet it still suffers from lack of specific targeting of cancer cells and poor accumulation at the tumor site. Consequently, targeted administration of chemotherapy medications has been employed in cancer treatment. Doxorubicin (DOX) is one of the most frequently used chemotherapeutics, functioning by inhibiting topoisomerase activity. Enhancing the anti-cancer effects of DOX and overcoming drug resistance can be accomplished via delivery by nanoparticles. This review will focus on the development of peptide-DOX conjugates, the functionalization of nanoparticles with peptides, the co-delivery of DOX and peptides, as well as the theranostic use of peptide-modified nanoparticles in cancer treatment. The peptide-DOX conjugates have been designed to enhance the targeted delivery to cancer cells by interacting with receptors that are overexpressed on tumor surfaces. Moreover, nanoparticles can be modified with peptides to improve their uptake in tumor cells via endocytosis. Nanoparticles have the ability to co-deliver DOX along with therapeutic peptides for enhanced cancer treatment. Finally, nanoparticles modified with peptides can offer theranostic capabilities by facilitating both imaging and the delivery of DOX (chemotherapy).","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"140143"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143035577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enthalpy driven temperature-sensitive conformational changes in a metamorphic protein involved in the cyanobacterial circadian clock.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-01-26 DOI: 10.1016/j.ijbiomac.2025.140360

Buyuan Ma, Zengxin Ma, Ning Zhang

引用次数: 0

Sodium alginate/low methoxyl pectin composite hydrogel beads prepared via gas-shearing technology for enhancing the colon-targeted delivery of probiotics and modulating gut microbiota.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-01-26 DOI: 10.1016/j.ijbiomac.2025.140375

Fan Zhang, Xujiao Zheng, Ying Ma, Wuqiang Nan, Wenjing Wu, Ziru Chu, Xin Sun, Jihong Huang, Marat Muratkhan, Fangfang Yue, Xin Wang, Xin Lü

{"title":"Sodium alginate/low methoxyl pectin composite hydrogel beads prepared via gas-shearing technology for enhancing the colon-targeted delivery of probiotics and modulating gut microbiota.","authors":"Fan Zhang, Xujiao Zheng, Ying Ma, Wuqiang Nan, Wenjing Wu, Ziru Chu, Xin Sun, Jihong Huang, Marat Muratkhan, Fangfang Yue, Xin Wang, Xin Lü","doi":"10.1016/j.ijbiomac.2025.140375","DOIUrl":"10.1016/j.ijbiomac.2025.140375","url":null,"abstract":"The probiotic encapsulation system has the potential to enhance the prebiotic effects of probiotics. However, challenges arise from the release behavior of this system in vivo and the large size of hydrogel beads. This study aims to address the issues related to the size of previous hydrogel beads and assess the colon-targeted delivery of probiotic polysaccharides composite hydrogel beads (PPHB). PPHB prepared by gas-shearing technique significantly reduced the average particle size and demonstrated a high protective capacity for probiotics (after simulating intestinal conditions for 4 h, the viability of encapsulated probiotics remained at 107 CFU/g). The use of indocyanine green along with near-infrared-II in vivo imaging technology demonstrated the colon-targeted delivery of PPHB in vivo, which also extended the retention time of probiotics in the cecum and colon. Additionally, the colon-targeted delivery of PPHB was also demonstrated by dietary supplementation in vivo. PPHB significantly enhanced the diversity and richness of intestinal microflora species, increased the levels of short-chain fatty acids, raised the relative abundance of beneficial bacteria, and significantly decreased the relative abundance of harmful bacteria. Alginate-based PPHB is more suitable for encapsulating functional ingredients for colon-targeted delivery and modulating gut microbiota.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"140375"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Licorice endophytes activate glycyrrhizin synthesis metabolic flux through feedback of β-glucuronidase conversion activity.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-01-29 DOI: 10.1016/j.ijbiomac.2025.140484

Xin Zuo, Yao Xu, Guangxi Ren, Dan Jiang, Chunsheng Liu

{"title":"Licorice endophytes activate glycyrrhizin synthesis metabolic flux through feedback of β-glucuronidase conversion activity.","authors":"Xin Zuo, Yao Xu, Guangxi Ren, Dan Jiang, Chunsheng Liu","doi":"10.1016/j.ijbiomac.2025.140484","DOIUrl":"10.1016/j.ijbiomac.2025.140484","url":null,"abstract":"Terpenoids are widely distributed in plants and are often used as defense molecules in plant-microbe interactions. However, endophytic microorganisms usually establish a better symbiotic relationship with their hosts by secreting enzymes to avoid defense plant metabolites. This study evaluated the in vitro biotransformation activity of licorice endophytic fungi on glycyrrhizin and further explored the molecular regulation of their in vivo colonization on the licorice growth and metabolism. The results indicated that licorice endophytic fungi generally possessed the ability to bio-transform glycyrrhizin, with Z6 and Z15 exhibiting glycyrrhizin-induced β-glucuronidase activity. The Z6GH2 and Z15GH2 proteins were identified to hydrolyze glycyrrhizin in different ways by prokaryotic and eukaryotic experiments. In vivo re-infestation of licorice by Z6 and Z15 revealed significant promotion of glycyrrhizin biosynthesis and accumulation by regulating the expression levels of genes involved in glycolysis and glycyrrhizin biosynthesis pathway in licorice. These findings were further validated in J3, which has glycyrrhizin biotransformation properties. In summary, this study reveals the molecular mechanism by which endophytic fungi with glycyrrhizin β-glucuronidase activity promote glycyrrhizin biosynthesis and accumulation in licorice through feedback regulation of its metabolic flux. These finding highlight the importance of endophytic fungi in regulating the accumulation of active ingredients in medicinal plants.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"140484"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Freeze-thaw pretreatment improved the anti-digestibility and viscosity of corn starch/type-A gelatin complexes.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-02-03 DOI: 10.1016/j.ijbiomac.2025.140648

Yi Liu, Jihong Qu, Die Dong, Zhengzong Wu, Huiyan Ma, Lu Lu, Zheng Zhang, Chao Yuan, Meng Zhao, Bo Cui

{"title":"Freeze-thaw pretreatment improved the anti-digestibility and viscosity of corn starch/type-A gelatin complexes.","authors":"Yi Liu, Jihong Qu, Die Dong, Zhengzong Wu, Huiyan Ma, Lu Lu, Zheng Zhang, Chao Yuan, Meng Zhao, Bo Cui","doi":"10.1016/j.ijbiomac.2025.140648","DOIUrl":"10.1016/j.ijbiomac.2025.140648","url":null,"abstract":"Slowly digestible starches, known to confer health benefits, are often prepared via compounding with other substances. However, starch complexes often encounter problems such as low viscosity. This work aimed to develop a corn starch/type-A gelatin (CS/GA) complex that simultaneously exhibited rapidly digestible starch (RDS) reduction, and superior viscosity. The pH and drying temperature of the complexes were systematically optimized, and a novel freeze-thaw pretreatment (FTP) technique was innovatively introduced. This work investigated the effects of varying FTP cycles (ranging from 0 to 8) on the physicochemical properties of CS/GA complexes. Results showed that FTP significantly enhanced the viscosity of the complexes while effective RDS reduction. Notably, after six FTP cycles, the complexes attained optimal properties, characterized by the highest the complex index (CI), relative crystallinity (RC) and short-range molecular order, accompanied by the lowest RDS reduction of 46.24 %. The multivariate analysis revealed CI as the crucial parameter for altering the resistant starch (RS) content. Furthermore, FTP induced cracking on the surface of starch particles was observed. In conclusion, these results were of significance for developing CS-based food materials with RDS reduction, and high viscosity characteristics, such as noodles, corn porridge and sausage.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"140648"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced chitosan hybrid dye labels for dynamic monitoring of shrimp and milk freshness.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-02-03 DOI: 10.1016/j.ijbiomac.2025.140652

Arnat Ronte, Jongjit Chalitangkoon, Tanaporn Sintoppun, Nantawan Niemhom, Nuttaporn Manapradit, Pimpaporn Munpiriyakul, E Johan Foster, Pathavuth Monvisade

{"title":"Advanced chitosan hybrid dye labels for dynamic monitoring of shrimp and milk freshness.","authors":"Arnat Ronte, Jongjit Chalitangkoon, Tanaporn Sintoppun, Nantawan Niemhom, Nuttaporn Manapradit, Pimpaporn Munpiriyakul, E Johan Foster, Pathavuth Monvisade","doi":"10.1016/j.ijbiomac.2025.140652","DOIUrl":"10.1016/j.ijbiomac.2025.140652","url":null,"abstract":"This study presents the development of intelligent screen-printed labels for real-time food freshness monitoring. Using chitosan grafted with rosolic acid (RA) and immobilized on montmorillonite (MMT) through cationic exchange, a hybrid dye was synthesized and applied in screen-printing inks. The hybrid structure was characterized by XRD, TGA, and UV-vis, confirming improved thermal stability and maintained halochromic properties. SEM analysis showed consistent ink deposition on filter paper, while water contact angle (WCA) measurements demonstrated enhanced surface hydrophobicity due to the MMT. The labels exhibited clear pH-sensitive color transitions from yellow to purplish red (pH 2.0-12.0) and rapid ammonia sensitivity, with ΔE values exceeding 45.0 within 10 min. The labels also demonstrated excellent reversibility, storage stability, leaching resistance, and cytocompatibility. Practical tests on shrimp and milk confirmed the labels' ability to accurately monitor freshness through visible color changes. These findings highlight the potential of hybrid labels as effective, scalable freshness indicators for intelligent food packaging.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"140652"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0