International Journal of Biological Macromolecules最新文献_第3页

Injectable oxidized hyaluronic acid/quaternized chitosan hydrogel encapsulated with diacerein microsphere for improved osteoarthritis treatment. 注射氧化透明质酸/季铵化壳聚糖水凝胶包被二皂素微球改善骨关节炎的治疗。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-06-18 DOI: 10.1016/j.ijbiomac.2025.145395

Bingwen Zhang, Tong Cao, Jinkuo Cao, Yixuan Li, Liandong Hu

{"title":"Injectable oxidized hyaluronic acid/quaternized chitosan hydrogel encapsulated with diacerein microsphere for improved osteoarthritis treatment.","authors":"Bingwen Zhang, Tong Cao, Jinkuo Cao, Yixuan Li, Liandong Hu","doi":"10.1016/j.ijbiomac.2025.145395","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.145395","url":null,"abstract":"<p><p>This study introduces a novel injectable, dynamically crosslinked hydrogel composite delivery system, diacerein microspheres (DIA-MS) encapsulated within a hydrogel matrix (DIA-MS@gel), for the potential treatment of osteoarthritis (OA). DIA-MS was fabricated using a T-junction microfluidic device. The injectable hydrogel was synthesized through the reaction of oxidized hyaluronic acid (OHA), quaternized chitosan (QCS), and adipic acid dihydrazide (ADH). Subsequently, DIA-MS was encapsulated into the hydrogel to form the DIA-MS@gel composite. The DIA-MS@gel was characterized by morphology, swelling behavior, pH response, degradability, and drug release kinetics. In vitro experiments showed that DIA-MS@gel could effectively prolong the drug release time to 47 days and showed pH-responsive degradation behavior. In vivo studies in rabbits indicated that intra-articular (IA) injection of DIA-MS@gel facilitated articular cartilage repair. The DIA-MS@gel provided continuous drug release for over 31 days within the rabbit joint cavity, potentially reducing administration frequency, attenuating inflammation, and promoting bone tissue regeneration. Furthermore, the DIA-MS@gel exhibited excellent biocompatibility, suggesting its potential as a practical clinical approach for managing OA.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"145395"},"PeriodicalIF":7.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Jute nanocrystalline cellulose enhances stress resilience in Lactobacillus rhamnosus by modulating transcriptional homeostasis. 黄麻纳米晶纤维素通过调节转录稳态增强鼠李糖乳杆菌的应激恢复能力。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-06-18 DOI: 10.1016/j.ijbiomac.2025.145364

Liangbin Li, Yuanyuan Zhang, Haiyang Chi, Chenxiao Chen, Sa Yang, Xiushi Yang, Chunsheng Hou, Yanchun Deng

{"title":"Jute nanocrystalline cellulose enhances stress resilience in Lactobacillus rhamnosus by modulating transcriptional homeostasis.","authors":"Liangbin Li, Yuanyuan Zhang, Haiyang Chi, Chenxiao Chen, Sa Yang, Xiushi Yang, Chunsheng Hou, Yanchun Deng","doi":"10.1016/j.ijbiomac.2025.145364","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.145364","url":null,"abstract":"<p><p>Probiotics, particularly Lactobacillus rhamnosus, are critical for gut health and immune function but encounter significant challenges from environmental stressors during production and gastrointestinal transit. This study demonstrated that jute-derived nanocrystalline cellulose (JNCC), a novel dietary fiber, at low doses (0.1-10 μg/mL), effectively protects L. rhamnosus against various stresses, including heat, oxidative, and antibiotic (such as kanamycin and ampicillin) treatment. Optimal protection was observed at 1 μg/mL JNCC, which preserved cellular morphology and viability under various stress conditions. Monosaccharide composition analysis revealed JNCC primarily comprising rhamnose (30.95 %), glucuronic acid (29.58 %), and galacturonic acid (20.61 %). Transcriptomic and phenotypic analyses further indicated that JNCC maintains probiotic resilience by significantly modulating the expression level of genes related to membrane protein transport and DNA integration pathways, thereby stabilizing transcriptional homeostasis. The work revealed JNCC as a promising low-dose prebiotic additive to enhance probiotic survival in implications for functional food and biomedical applications.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"145364"},"PeriodicalIF":7.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal-carbon dual network reinforced bismuth-based chitosan hydrogels for improved photoresponsiveness, antibacterial activity, and wound healing. 金属-碳双网增强铋基壳聚糖水凝胶，用于改善光反应性，抗菌活性和伤口愈合。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-06-18 DOI: 10.1016/j.ijbiomac.2025.145376

Xiyan Ding, Ma Bai, Jialun Yang, Jiaqi Li, Mengyao Wang, Xueqing Wang, Pengyue Li, Jing Wang, Miao Liu, Guangjun Huang, Lili Ma, Jinyou Duan

{"title":"Metal-carbon dual network reinforced bismuth-based chitosan hydrogels for improved photoresponsiveness, antibacterial activity, and wound healing.","authors":"Xiyan Ding, Ma Bai, Jialun Yang, Jiaqi Li, Mengyao Wang, Xueqing Wang, Pengyue Li, Jing Wang, Miao Liu, Guangjun Huang, Lili Ma, Jinyou Duan","doi":"10.1016/j.ijbiomac.2025.145376","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.145376","url":null,"abstract":"<p><p>Photodynamic therapy (PDT) is widely recognized as an effective antimicrobial strategy that minimizes the risk of bacterial resistance. Exploiting the intrinsic properties of hydrogels to create a favorable microenvironment for wound healing, researchers integrated bismuth-based metal particles into a chitosan-polyvinyl alcohol gel matrix. Representative gel complexes after metal-gel networks (Bi-gel) and composites introduced by biomass-derived carbon (BC) immobilized by cross-linking are referred to as CP/BC@Bi. The incorporation of carbon created a dual-network that enhanced electron transfer at the Bi‑carbon heterojunction, reduced electron-hole recombination, and optimized photogenerated carrier separation and migration. In vitro experiments showed that the excessive reactive oxygen species (ROS) generated by CP/BC@Bi under visible light enhanced PDT-mediated antimicrobial efficacy, causing complete bacterial membrane disruption and biofilm inhibition. Additionally, the surface roughness and defects of CP/BC@Bi enhanced bacterial adhesion, promoting ROS-bacterial interactions and amplifying its antimicrobial effects. Notably, the inhibition rates for Escherichia coli and Staphylococcus aureus were found to be 96 % and 94 %, respectively. Biocompatibility was rigorously assessed through hemocompatibility, cytotoxicity, and post-healing tissue staining experiments, all of which confirmed the safety profile of the hydrogel. In vivo studies demonstrated that wounds treated with PDT-CP/BC@Bi exhibited significantly accelerated healing rates, substantial dermal tissue regeneration, and normalized levels of inflammatory markers. This work demonstrates the potential of the environmentally friendly, resistance-free photodynamic antimicrobial hydrogel dressing in wound healing while offering insights into optimizing Bi-based hydrogels.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"145376"},"PeriodicalIF":7.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel insights showing SecA protein localization and distribution of phytoplasma in insect vector Empoasca paraparvipenis. SecA蛋白定位及植物原体在昆虫载体paraparvipenis中的分布。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-06-18 DOI: 10.1016/j.ijbiomac.2025.145261

Kai Qiao, Fan Su, Weiyi Huang, Xuemei Li, Yinfen Cai, Shahzad Munir, Hong Cai

{"title":"Novel insights showing SecA protein localization and distribution of phytoplasma in insect vector Empoasca paraparvipenis.","authors":"Kai Qiao, Fan Su, Weiyi Huang, Xuemei Li, Yinfen Cai, Shahzad Munir, Hong Cai","doi":"10.1016/j.ijbiomac.2025.145261","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.145261","url":null,"abstract":"<p><p>The Camptotheca acuminata witches-broom (CaWB-YNws) is one of the most severe diseases of C. acuminata and the insect vector is Empoasca paraparvipenis Zhang and Liu-CA (E. paraparvipenis-CA). Here, we reported the population of insect vector throughout the year in the Dashidong area, Wenshan, Yunnan Province, China. The occurrence of E. paraparvipenis was observed during the early epidemic stage in April, the summer peak epidemic stage in July, and the overwintering stage in November. Next, we established a set of immunofluorescence systems based on a polyclonal antibody against the SecA protein of the CaWB-YNws. We found that third instar E. paraparvipenis, after feeding the CaWB-YNws at different feeding times, demonstrated the movement from the anterior midgut to the midgut, where the pathogen assembled. Furthermore, after feeding on the infected host for 2 h, the third, fourth, and fifth instar insect vectors exhibit a green fluorescence signal in the anterior midgut, midgut, and salivary, as well as the anterior midgut and midgut of the fifth instar insect vectors. We found that the infection rate declined with increasing age. Our findings establish the interaction mechanism between the CaWB-YNws and the E. paraparvipenis and provide a new research insight for the prevention.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"145261"},"PeriodicalIF":7.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polysaccharides from Chrysanthemum morifolium: Optimization of ultrafiltration isolation and anti-oxidant and anti-inflammatory effects. 菊花多糖：超滤分离及抗氧化抗炎作用的优化。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-06-18 DOI: 10.1016/j.ijbiomac.2025.145383

Hua Hang, Dongsheng Du, Yue Xing, Ke Li, Runze Chen, Yanru Sun, Changbao Wang

{"title":"Polysaccharides from Chrysanthemum morifolium: Optimization of ultrafiltration isolation and anti-oxidant and anti-inflammatory effects.","authors":"Hua Hang, Dongsheng Du, Yue Xing, Ke Li, Runze Chen, Yanru Sun, Changbao Wang","doi":"10.1016/j.ijbiomac.2025.145383","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.145383","url":null,"abstract":"<p><p>Chrysanthemum morifolium (Huangshan Gongju) crude polysaccharide (PCMC) has attracted considerable attention in the pharmaceutical and food industries due to its potential anti-oxidant and anti-inflammatory activities. This study aims to optimize its purification and concentration process using ultrafiltration technology, which was used to purify and concentrate the bio-macromolecular solutes. Employing PCM-C as the rough material, single-factor trials and response surface methodology (RSM) were used to estimate the effects of pressure, temperature and concentration for ultrafiltration on membrane fluxes. The built regression model was obviously typical, and the optimum conditions of ultrafiltration isolation were obtained as follows: 0.27 MPa, 51°Cand material concentration of 2.9 mg/mL. A membrane flux of PCM-C solution attained 39.26 ± 0.1 L/m<sup>2</sup>·h at the optimum condition. Two polysaccharides (PCM-I and PCM-II) obtained from ultrafiltration isolation. Fourier transform infrared (FT-IR) spectroscopy properties of PCMs (including PCMC, PCM-I and PCM-II) ascertained the significant absorption peaks of polysaccharides. The SEM images of PCMs microstructure illustrated typical properties of amorphous powders. The anti-oxidant activity of PCMs contained DPPH scavenging radicals, hydroxyl radicals, ABTS scavenging radicals and reducing power discovered that PCM-II possessed the maximal anti-oxidant capacity values for 76.8 %, 89.6 %, 78.3 % and 77.2 %, respectively. Furthermore, PCM-I inhibited expression of inflammation-related genes for NO release at lower concentration of 25 μg/mL, IL - 1β and IL-6 expression levels of 87.78 % and 52.17 %, and TNF-α expression level of 33.02 %, which showed that PCM-I had relatively stronger anti-inflammatory effects on RAW264.7 cell growth. Thus, the outcomes exhibited that PCM-I could serve as the potential bio-functional component for the pharmaceutical and food industry.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"145383"},"PeriodicalIF":7.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation, structural characterization, and potential applications of diatomaceous earth biomineralized with inorganic calcium and edible polysaccharide composite hydrogels. 无机钙生物矿化硅藻土-食用多糖复合水凝胶的制备、结构表征及应用前景

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-06-18 DOI: 10.1016/j.ijbiomac.2025.145369

Mei Zeng, Jun Liu, Qianmin Lin, Weiyang Kuang, Supaluck Kraithong, Xiaoyong Zhang, Saiyi Zhong, Riming Huang

{"title":"Preparation, structural characterization, and potential applications of diatomaceous earth biomineralized with inorganic calcium and edible polysaccharide composite hydrogels.","authors":"Mei Zeng, Jun Liu, Qianmin Lin, Weiyang Kuang, Supaluck Kraithong, Xiaoyong Zhang, Saiyi Zhong, Riming Huang","doi":"10.1016/j.ijbiomac.2025.145369","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.145369","url":null,"abstract":"<p><p>Algal polysaccharides are a key source of materials in food, cosmetics, and medical devices due to their excellent bioactivity. The Ulva pertusa polysaccharide was extracted from U. pertusa via hot-water extraction, and the diatomaceous earth was doped with inorganic calcium through a biosynthesis technique. To expand the application of algal polysaccharides, a novel Ca-DE/UPP composite hydrogel was developed by incorporating biomineralized diatomaceous earth (DE) into algal polysaccharide (UPP). The structure of the composite gel was characterized using rheology, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and X-ray Photoelectron Spectroscopy (XPS). A gelation mechanism was proposed based on these characterization data. Additionally, the hydrogel exhibited high mechanical strength (G' = 233 Pa), as well as impressive water retention (88.4 %) and water absorption (5.2 g/g). The Ca-DE/UPP composite hydrogel exhibits good cell compatibility and anti-inflammatory properties. Finally, in vitro, scratch assays demonstrated significant enhancement in cell migration, with a migration rate of up to 99.48 % after 48 h. These results suggest the hydrogel's potential as an effective wound dressing for promoting tissue regeneration.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"145369"},"PeriodicalIF":7.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing stability and antioxidant activity of lyophilized guar gum-coated neohesperidin-loaded nano-nutriosomes in functional dairy beverages 增强功能性乳制品饮料中瓜尔胶包被新橙皮苷纳米营养小体的稳定性和抗氧化活性

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-06-18 DOI: 10.1016/j.ijbiomac.2025.145193

Bolai Paul , Lianghua Xie , Zineb Ould Yahia , Ahmed K. Rashwan , Wei Chen

{"title":"Enhancing stability and antioxidant activity of lyophilized guar gum-coated neohesperidin-loaded nano-nutriosomes in functional dairy beverages","authors":"Bolai Paul , Lianghua Xie , Zineb Ould Yahia , Ahmed K. Rashwan , Wei Chen","doi":"10.1016/j.ijbiomac.2025.145193","DOIUrl":"10.1016/j.ijbiomac.2025.145193","url":null,"abstract":"<div><div>Neohesperidin (NH) is among the most promising flavonoids, but its use in functional foods, particularly beverages, is limited due to its low water solubility, instability, and biological activity. A new freeze-dried guar gum-coated nano-nutriosomes (FD-GG-NS) has demonstrated significant potential in addressing these issues. The objective of this work was to create and evaluate novel freeze-dried guar gum-coated nano-nutriosomes that would increase the physicochemical stability and antioxidant activity of NH in dairy-based beverages. The findings displayed that NH was successfully encapsulated in freeze-dried NS and GG-NH-NS, with good encapsulation efficacy (>94.64 %) and particle sizes ranging from 152.47 ± 1.74 to 194.63 ± 0.44 nm within an acceptable range PDI (<0.3). In addition, the FD-NH-NS had more stability in 10 mM NaCl and hydrophilic conditions during the storage period. Firstly, 0.4 % was determined to be the ideal concentration due to better stability and dietary fiber content. The FD-GG-NH-NS in dairy beverages enhanced the color, turbidity, ζ-potential, and sensory aspects, while decreasing viscosity and acidity with better antioxidant activity during the storage period, and better-controlled release of NH in SGF and SIF conditions. Therefore, incorporating NH into functional dairy drinks via guar gum-coated nano-nutriosomes has numerous applications in the food industry.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"319 ","pages":"Article 145193"},"PeriodicalIF":7.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery, expression, and characterization of highly tolerant superoxide dismutases from extremophiles for potential industrial applications 极端微生物高耐受性超氧化物歧化酶的发现、表达和表征及其潜在的工业应用

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-06-18 DOI: 10.1016/j.ijbiomac.2025.145272

Naying Zhang, Zefeng Ren, Dongsheng Wei, Meng Yang, Meng Niu, Chunxiao Shen, Xuanyan Jin, Maolin Wei, Jaehwan Choi, Myeongsam Park, Zhengqun Li

{"title":"Discovery, expression, and characterization of highly tolerant superoxide dismutases from extremophiles for potential industrial applications","authors":"Naying Zhang, Zefeng Ren, Dongsheng Wei, Meng Yang, Meng Niu, Chunxiao Shen, Xuanyan Jin, Maolin Wei, Jaehwan Choi, Myeongsam Park, Zhengqun Li","doi":"10.1016/j.ijbiomac.2025.145272","DOIUrl":"10.1016/j.ijbiomac.2025.145272","url":null,"abstract":"<div><div>Superoxide dismutases (SODs) are essential enzymes that protect cells by converting harmful superoxide radicals into oxygen and hydrogen peroxide. However, their application in industrial and medical settings is often limited by poor stability under extreme conditions such as high temperatures, extreme pH, and oxidative stress. In this study, we identified and characterized two highly stable manganese-dependent SODs from extremophiles. These enzymes remained highly active at temperatures up to 80 °C, across a broad pH range (3.0–12), and in the presence of oxidative agents and denaturing chemicals. Structural analysis revealed that their exceptional stability is attributed to tightly folded structures, strong hydrophobic cores, and robust metal-binding sites. Both <em>Os</em>SOD and <em>Gt</em>SOD demonstrated robust catalytic performance, with <em>k</em><sub><em>ca</em>t</sub><em>k</em><sub><em>m</em></sub> values of 2.29 × 10<sup>7</sup> and 1.06 × 10<sup>7</sup> M<sup>−1</sup>·s<sup>−1</sup>, respectively. In cell-based models, they effectively reduced oxidative stress and inflammation, indicating potential for antioxidant therapy. Additionally, their long-term stability supports their use in cosmetic and pharmaceutical formulations. Overall, these extremophile-derived SODs are highly stable and efficient enzymes with broad potential for industrial, medical, and cosmetic applications.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"319 ","pages":"Article 145272"},"PeriodicalIF":7.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thioctic acid driven chemical cross-linking of cellulose chains for fabricating high-performance cellulose films as food packaging 硫辛酸驱动的纤维素链化学交联制备高性能食品包装纤维素薄膜

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-06-18 DOI: 10.1016/j.ijbiomac.2025.145076

Youjie Gao , Guozhuo Chen , Chao Wu , Junjie Zhou , Guojun Jin , Hou-Yong Yu

{"title":"Thioctic acid driven chemical cross-linking of cellulose chains for fabricating high-performance cellulose films as food packaging","authors":"Youjie Gao , Guozhuo Chen , Chao Wu , Junjie Zhou , Guojun Jin , Hou-Yong Yu","doi":"10.1016/j.ijbiomac.2025.145076","DOIUrl":"10.1016/j.ijbiomac.2025.145076","url":null,"abstract":"<div><div>The widespread use of plastic packaging has improved convenience in daily life but has also led to serious environmental pollution. Therefore, an eco-friendly biodegradable material is needed to replace plastic packaging. In this study, the cellulose packaging materials were first time prepared by Thioctic acid (TA) driven chemical cross-linking with cellulose chains. Cellulose films with optimized concentrations of TA exhibited higher mechanical strength (126 MPa), hydrophobicity (99.7°), and barrier properties. The cross-linking of TA resulted in an orderly arrangement of cellulose molecules. Meanwhile, the cellulose film could effectively slow down evaporation of water from fruit (tomatoes) and extended food's shelf life for packaging applications, which is equivalent to commercial preservative film (polyethylene). This study presents a novel and scalable strategy for fabricating cellulose-based packaging materials with improved functional properties, offering a promising alternative to conventional plastic packaging.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"318 ","pages":"Article 145076"},"PeriodicalIF":7.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep-m7G: A contrastive learning-based deep biological language model for identifying RNA N7-methylguanosine sites deep - m7g：一个基于对比学习的深度生物语言模型，用于识别RNA n7 -甲基鸟苷位点

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-06-18 DOI: 10.1016/j.ijbiomac.2025.145341

Meng Zhang , Jing Wu , Yulan Wang , Yan Cao , Jingjing Liu , Quan Wang , Xiaofeng Song , Jian Zhao , Yixuan Wang

{"title":"Deep-m7G: A contrastive learning-based deep biological language model for identifying RNA N7-methylguanosine sites","authors":"Meng Zhang , Jing Wu , Yulan Wang , Yan Cao , Jingjing Liu , Quan Wang , Xiaofeng Song , Jian Zhao , Yixuan Wang","doi":"10.1016/j.ijbiomac.2025.145341","DOIUrl":"10.1016/j.ijbiomac.2025.145341","url":null,"abstract":"<div><div>N7-methylguanosine (m7G) is one of the most prevalent post-transcriptional modifications in RNA molecules, playing a pivotal role in regulating RNA metabolism and function. Given the complexity of canonical m7G cap-dependent protein synthesis, accurately predicting m7G modification sites facilitates further exploration of translation initiation mechanisms. Hence, we collected the most comprehensive single-nucleotide resolution m7G modification sites from the updated m7GHub v2.0 database. We subsequently developed Deep-m7G, a novel contrastive learning-enhanced deep biological language model, designed for both the full transcript and mature RNA datasets. Our methodological framework incorporates three key innovations: (1) implementation of a Most Distant undersampling strategy to mitigate class imbalance in training data; (2) integration of DNABERT-2 with a parallel convolutional neural network architecture for hierarchical feature extraction; and (3) introduction of a contrastive learning module to enhance feature discriminability and model generalizability. Systematic evaluation through 10-fold cross-validation demonstrated the critical contribution of our contrastive learning component. In rigorous benchmarking against existing tools, Deep-m7G achieved superior predictive performance (Full transcript: AUC = 0.960 vs 0.653–0.898 and Mature RNA: AUC = 0.845 vs 0.684–0.832) on independent test sets. Collectively, this computational advance provides a robust framework for the discovery of epitranscriptomics markers, thereby advancing mechanistic investigations of post-transcriptional regulation.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"318 ","pages":"Article 145341"},"PeriodicalIF":7.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0