International Journal of Biological Macromolecules最新文献_第3页

Corrigendum to "Comparative evaluation of liposome and ergosterol-niosome systems for encapsulation of goat milk protein hydrolysates: Structural properties, in vitro digestive stability, and storage stability" [Int. J. Biol. Macromol. 349 (2026) 150869]. 羊奶蛋白水解物包封用脂质体和麦角甾醇-niosome系统的比较评价：结构特性、体外消化稳定性和储存稳定性[Int.]生物。[j].生物工程学报，2014,30(5):357 - 357。

IF 8.5 1区化学

International Journal of Biological Macromolecules Pub Date : 2026-05-05 DOI: 10.1016/j.ijbiomac.2026.152321

Bohan Ma, Qin Shu, Wenhua Zhang, Linqiang Li, Yongfeng Liu

引用次数: 0

PVA/alginate/maltose microneedle patch loaded with ZIF-8 and Cu-containing ZIF-8 for full-thickness wound healing: In vitro and in vivo studies. PVA/海藻酸盐/麦芽糖微针贴片装载ZIF-8和含cu的ZIF-8用于全层伤口愈合：体外和体内研究。

IF 8.5 1区化学

International Journal of Biological Macromolecules Pub Date : 2026-05-05 DOI: 10.1016/j.ijbiomac.2026.152402

Parsa Ghaemmaghami, Rouhollah Mehdinavaz Aghdam, Rezvan Jamaledin, Alireza Koohikar, Seyed Hossein Ahmadi Tafti, Safieh Boroumand, Mohammad Amin Fathollah Maghsoudi, Azadeh Ghaee, Raffaele Vecchione, Asieh Heirani-Tabasi, Paolo Antonio Netti

{"title":"PVA/alginate/maltose microneedle patch loaded with ZIF-8 and Cu-containing ZIF-8 for full-thickness wound healing: In vitro and in vivo studies.","authors":"Parsa Ghaemmaghami, Rouhollah Mehdinavaz Aghdam, Rezvan Jamaledin, Alireza Koohikar, Seyed Hossein Ahmadi Tafti, Safieh Boroumand, Mohammad Amin Fathollah Maghsoudi, Azadeh Ghaee, Raffaele Vecchione, Asieh Heirani-Tabasi, Paolo Antonio Netti","doi":"10.1016/j.ijbiomac.2026.152402","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.152402","url":null,"abstract":"An ideal microneedle array for promoting wound healing should possess mechanical strength, antibacterial, anti-inflammatory, and angiogenic properties. In this study, we developed a microneedle array with a PVA-Alginate-Maltose (PAM) matrix, within which Cu@ZIF-8 metal-organic framework nanoparticles were encapsulated for enhanced wound healing. We fabricated microneedle arrays containing 0%, 1%, and 3% w/w Cu@ZIF-8 (CZ), as well as a control group with 3% ZIF-8. The physical and chemical characteristics of both the nanoparticles and the microneedle arrays were analyzed using FESEM, XRD, FTIR, and EDS. The addition of maltose in the polymer matrix resulted in an increase in compressive force from 0.03 N/needle to 0.143 N/needle; by adding 3% Cu@ZIF-8, this value further increased to 0.156 N/needle, achieving a tip sharpness of 5.1 μm. In vitro studies demonstrated that the microneedles exhibited significant antibacterial activity, good biocompatibility, and an effective release rate of zinc and copper ions proved beneficial for wound closure. In vivo tests using immunohistochemical and histopathological analyses demonstrated that PAMCZ3% microneedles facilitated the highest levels of wound healing, epithelial layer regeneration, angiogenesis, and reduced scar formation. These findings suggest that the proposed PAMCZ3% microneedles could be applicable in clinical wound healing treatments.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"152402"},"PeriodicalIF":8.5,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural rewiring of the mannose-binding pocket reveals adaptive FimH mutations that enhance uroplakin-associated glycan recognition and uropathogenic adhesion. 甘露糖结合囊的结构重新连接揭示了适应性的FimH突变，增强了尿激酶相关的聚糖识别和尿路致病性粘附。

IF 8.5 1区化学

International Journal of Biological Macromolecules Pub Date : 2026-05-05 DOI: 10.1016/j.ijbiomac.2026.152407

Shashank Shekhar, Khushboo Bhagat, Aditya K Padhi

{"title":"Structural rewiring of the mannose-binding pocket reveals adaptive FimH mutations that enhance uroplakin-associated glycan recognition and uropathogenic adhesion.","authors":"Shashank Shekhar, Khushboo Bhagat, Aditya K Padhi","doi":"10.1016/j.ijbiomac.2026.152407","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.152407","url":null,"abstract":"Urinary tract infections (UTIs) are a major global health burden, with uropathogenic Escherichia coli (UPEC) as the leading causative agent. UPEC adhesion is mediated by the fimbrial lectin FimH, which recognizes high-mannose glycans on the urothelial uroplakin (UPK) complex. While FimH interactions with isolated glycans are structurally characterized, its recognition of UPK1A-tethered glycans within the intact human UPK architecture remains unclear. In addition, the mutational logic by which the Mannose-Binding Pocket (MBP) is rewired to enhance glycan affinity and adaptive fitness has not been systematically explored. Here, multiscale structural modeling, interface-based protein redesign, and mutational energy profiling were used to define FimH-UPK-glycan interactions and identify affinity-modulating substitutions. Using the porcine UPK structure as a scaffold, human UPK assemblies complexed with oligomannose-3 (OM3) and oligomannose-6 (OM6) were modeled and analyzed. Comparative redesign of the FimH MBP across human and porcine UPK complexes generated 545 designs, which were prioritized using a robust median-based composite Z-score framework integrating affinity and stability effects. This identified adaptive high-affinity substitutions, notably N135S and Y137F in the human complex, and D54G and D47V in the porcine complex. Several affinity-reducing designs also showed strong concordance with experimentally-characterized FimH mutants and known glycan-binding trends, supporting the predictive robustness of the approach. Energy decomposition revealed increased hydrogen bonding and favorable van der Waals contacts in high-affinity designs, accompanied by enhanced conformational rigidity from normal mode analysis. These findings define the structural-energetic basis of FimH evolutionary fine-tuning toward UPK-associated glycans and provide a framework for rational anti-adhesive therapeutic design.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"152407"},"PeriodicalIF":8.5,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tailoring of amino functionalized graphene oxide/cellulose/chitosan composite for the determination of imidacloprid in milk samples. 氨基功能化氧化石墨烯/纤维素/壳聚糖复合材料测定牛奶样品中的吡虫啉。

IF 8.5 1区化学

International Journal of Biological Macromolecules Pub Date : 2026-05-04 DOI: 10.1016/j.ijbiomac.2026.152385

Waleed Altaf, Nadeem Raza, Muhammad Hayat, Saba Khalid, Farah Khan, Faisal K Algethami, Jameel Ahmad Baig, Mohamed Rahmtalla Elamin, Suryyia Manzoor

{"title":"Tailoring of amino functionalized graphene oxide/cellulose/chitosan composite for the determination of imidacloprid in milk samples.","authors":"Waleed Altaf, Nadeem Raza, Muhammad Hayat, Saba Khalid, Farah Khan, Faisal K Algethami, Jameel Ahmad Baig, Mohamed Rahmtalla Elamin, Suryyia Manzoor","doi":"10.1016/j.ijbiomac.2026.152385","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.152385","url":null,"abstract":"Cellulose and chitosan, due to their high mechanical strength and active functional groups are preferred in designing novel composites for solid phase extraction of diverse analytes from food, biological or environmental samples. In this study, an amino functionalized graphene oxide, cellulose and chitosan-based composite was designed and well characterized for the analysis of imidacloprid (IMI) in cow milk samples. Characterization of synthesized composite was done by using Fourier transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, thermogravimetric analysis and differential scanning calorimetry. Limit of detection and quantification of pesticide were found to be 5.5 × 10-3 mgL-1 and 1.65 × 10-2 mgL-1. Kinetic studies revealed that the adsorption process was governed by the pseudo first order mechanism. Optimization of different parameters revealed that best conditions for IMI adsorption were pH 5, adsorbent dose of 20 mg, IMI concentration of 35 mgL-1 and the contact time of 20 min. Thermodynamic studies showed ΔH° value of +20.0 kJmol-1, ΔS°, +155.1 JK-1 mol-1 and ΔG° at 298 K, 308 K, 318 K was -26.13, -27.68 and - 29.23 kJmol-1, respectively. To evaluate the real-time application of designed composite, IMI was determined in cow milk samples using dispersive solid phase microextraction followed by high-performance liquid chromatography. The composite showed a high percentage recovery of 95.4 ± 4.1% (n = 9) of IMI. These results indicate the effectiveness of composite in detecting the IMI in complex matrixes like milk, thus highlighting its effectiveness and potential as a reliable method in food analysis.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"152385"},"PeriodicalIF":8.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structurally engineered lignin-based robust, conductive ionic hydrogels via DMSO-assisted dual-network strategy for flexible sensors. 结构工程木质素为基础的坚固，导电离子水凝胶通过dmso辅助双网络策略柔性传感器。

IF 8.5 1区化学

International Journal of Biological Macromolecules Pub Date : 2026-05-04 DOI: 10.1016/j.ijbiomac.2026.152384

Xiaoqian Zhou, Jiatong Zhou, Yuanyuan Xu, Linlin Zhao, Cunshi Zhao, Ailing Xu, Xinhui Wang, Tianpeng Zhang, Dong Wang, Qingbo Wang, Yonggui Wang

{"title":"Structurally engineered lignin-based robust, conductive ionic hydrogels via DMSO-assisted dual-network strategy for flexible sensors.","authors":"Xiaoqian Zhou, Jiatong Zhou, Yuanyuan Xu, Linlin Zhao, Cunshi Zhao, Ailing Xu, Xinhui Wang, Tianpeng Zhang, Dong Wang, Qingbo Wang, Yonggui Wang","doi":"10.1016/j.ijbiomac.2026.152384","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.152384","url":null,"abstract":"Electronic skins and wearable sensors exhibit enormous application potential in emerging fields such as human health monitoring and human-machine interaction. Ionic hydrogels are promising soft conductors for electronic skins and wearable sensors, but they suffer from weak mechanical performance, swelling, and unstable ionic conduction in practical scenarios. Here, we propose a DMSO-assisted dual-network strategy for constructing lignin-based ionic hydrogels that integrate robustness, high ionic conductivity, and antibacterial activity. Alkaline lignin is modified into a multifunctional building block (LigBM3-C16) with crosslinkable sites and antibacterial property via esterification and quaternization. Copolymerization of LigBM3-C16 with acrylic acid and acrylamide in DMSO forms a homogeneous covalent DMSO gel, followed by FeCl3 solvent exchange to capture Fe3+ on uniformly phenolic and carboxylic groups from lignin and acrylic acid, forming a continuous hydrate coordination network. The resulting LigBM3-C16-Fe hydrogels exhibits excellent tensile strength (3.38 MPa) and toughness (9.76 MJ m-3) and ionic conductivity (σ = 27.4 mS cm-1), overcoming the typical trade-off between robustness and ion transport. Fe3+ coordination and quaternized lignin together provide broad-spectrum antibacterial/antioxidant activity. The resulting ionic hydrogel functions as stable strain sensors for real-time human motion monitoring and gesture-controlled human-machine interaction, offering a simple method to robust, multifunctional ionic hydrogels for flexible conducting materials.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"152384"},"PeriodicalIF":8.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An injectable pH-responsive marine polysaccharide hydrogel (AE&LF@pOA) for sequential therapy of infected diabetic wounds. 一种可注射的ph反应性海洋多糖水凝胶（AE&LF@pOA），用于糖尿病感染伤口的顺序治疗。

IF 8.5 1区化学

International Journal of Biological Macromolecules Pub Date : 2026-05-03 DOI: 10.1016/j.ijbiomac.2026.152378

Meiyue Zhao, Jialing Wu, Lihua Geng, Ning Wu, Yang Yue, Quanbin Zhang, Huaide Liu, Jing Wang

{"title":"An injectable pH-responsive marine polysaccharide hydrogel (AE&LF@pOA) for sequential therapy of infected diabetic wounds.","authors":"Meiyue Zhao, Jialing Wu, Lihua Geng, Ning Wu, Yang Yue, Quanbin Zhang, Huaide Liu, Jing Wang","doi":"10.1016/j.ijbiomac.2026.152378","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.152378","url":null,"abstract":"Chronic diabetic wound healing remains challenging owing to impaired angiogenesis, persistent inflammation, and a high risk of infection. To address these limitations, we developed an injectable, pH-responsive hydrogel based on dynamic crosslinking between phenylboronic acid-grafted oxidized agarose (pOA) and alginate oligosaccharide-conjugated ε-polylysine (AE). This hydrogel exhibits antibacterial and antioxidant properties, enabling on-demand drug release triggered by the acidic microenvironment of chronic wounds. To enhance therapeutic efficacy, low-molecular-weight fucoidan (LF), a potent pro-angiogenic marine polysaccharide, was encapsulated within the hydrogel. Physicochemical characterizations confirmed that the hydrogel possesses excellent structural stability, injectability, and pH-responsive sustained release properties for LF and AE. Subsequently, In vitro tests showed that the AE&LF@pOA hydrogel effectively controlled infection with a 77.3% antibacterial rate against Staphylococcus aureus and showed ROS scavenging activity. It also regulated the inflammatory response, reducing pro-inflammatory cytokines IL-1β and IL-6 by 53.8% and 64.4%, respectively while increasing anti-inflammatory cytokines IL-10 and TGF-β1 by 2.8-fold and 1.0-fold. Moreover, the hydrogel stimulated neovascularization, leading to a 4.7-fold increase in VEGF expression and a 50% increase in CD-31 microvessel density. Animal studies confirmed that the dressing accelerated macroscopic healing. The hydrogel accelerated wound closure to 85.8% by day 7, 2.7-fold higher than controls, with the residual wound area shrinking to just 1.4% by day 14. Histological analysis further demonstrated complete re-epithelialization to 80.3 μm thickness, and mature collagen deposition. Overall, this responsive hydrogel offers a promising strategy for treating chronic diabetic wounds.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"152378"},"PeriodicalIF":8.5,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Valorization of tea processing wastewater into multifunctional chitosan-based films for active food packaging. 茶叶加工废水转化为食品活性包装用多功能壳聚糖基薄膜的研究。

IF 8.5 1区化学

International Journal of Biological Macromolecules Pub Date : 2026-05-03 DOI: 10.1016/j.ijbiomac.2026.152368

Tianyi Hu, Wanqin Xu, Qun Liu, Nan Zhou, Wuyin Weng, Yucang Zhang

引用次数: 0

Multifunctional halogen-free phosphoryl amide derivative boosts fire safety, crystallizability, flexibility, and anti-UV of poly(L-lactic acid). 多功能无卤磷酰酰胺衍生物提高了聚l -乳酸的防火安全性、结晶性、柔韧性和抗紫外线性。

IF 8.5 1区化学

International Journal of Biological Macromolecules Pub Date : 2026-05-03 DOI: 10.1016/j.ijbiomac.2026.152274

Li Fan, Shuo Wang, Mikhail A Soldatov, Yuhong Xie, Wencong Tang, Qiran Wang, Yipaerguli Yiminniyazi, Leihua Jia, Junsheng Wang, Jinjun Yang

{"title":"Multifunctional halogen-free phosphoryl amide derivative boosts fire safety, crystallizability, flexibility, and anti-UV of poly(L-lactic acid).","authors":"Li Fan, Shuo Wang, Mikhail A Soldatov, Yuhong Xie, Wencong Tang, Qiran Wang, Yipaerguli Yiminniyazi, Leihua Jia, Junsheng Wang, Jinjun Yang","doi":"10.1016/j.ijbiomac.2026.152274","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.152274","url":null,"abstract":"While poly(L-lactic acid) (PLA) exhibits excellent biodegradability, biocompatibility, tensile strength, and processability, its inherent flammability, poor crystallization ability, and brittleness significantly limit its broader application. In this work, a halogen-free phosphoryl amide flame retardant agent (DMPC) was synthesized via a simple one-step nucleophilic substitution reaction to enhance the fire resistance of PLA. The results show that, compared with neat PLA, PLA/1% DMPC composite achieved a 39.0% increase in limiting oxygen index and attained the highest V-0 rating in the vertical burning test, along with self-extinguishing behavior. Cone calorimetry test further reveals an 85.5% longer time to ignition, along with reductions in peak heat release rate (27.9%), total heat release (26.9%), peak smoke production rate (76.4%), total smoke production (85.7%), CO2 production (34.8%), and fire growth rate index (31.6%), while the residue yield (RY) percentage increased by 26 times. This outstanding flame-retardant performance was primarily attributed to the formation of a compact, thick, and continuous char layer on the composite surface during combustion, which effectively insulated heat, limits oxygen diffusion, and suppressed smoke emission. Additionally, phosphorus‑oxygen radicals generated during pyrolysis scavenged oxygen radicals, thereby interrupting the combustion chain reaction. Beyond flame retardancy, the composite also exhibited exceptional UV-shielding performance, along with improved crystallization kinetics, enhanced hydrophobicity, and increased elongation at break. This work presents a feasible pathway for developing bio-based multifunctional flame-retardant composites and offers a practical solution for expanding the application potential of PLA-based products.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"152274"},"PeriodicalIF":8.5,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enzymatic functions of CmPAL1 and CmPAL2 in Chinese chestnut (Castanea mollissima BL.): Key catalysts in powdery mildew resistance via MeJA signaling. 板栗（Castanea mollissima BL.） CmPAL1和CmPAL2的酶功能：通过MeJA信号调控板栗抗白粉病的关键催化剂

IF 8.5 1区化学

International Journal of Biological Macromolecules Pub Date : 2026-05-02 DOI: 10.1016/j.ijbiomac.2026.152360

Wu Wang, Niels J Nieuwenhuizen, Shijie Zhang, Yu Chen, Yuqiang Zhao, Cancan Zhu, Guoming Wang

{"title":"Enzymatic functions of CmPAL1 and CmPAL2 in Chinese chestnut (Castanea mollissima BL.): Key catalysts in powdery mildew resistance via MeJA signaling.","authors":"Wu Wang, Niels J Nieuwenhuizen, Shijie Zhang, Yu Chen, Yuqiang Zhao, Cancan Zhu, Guoming Wang","doi":"10.1016/j.ijbiomac.2026.152360","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.152360","url":null,"abstract":"Phenylalanine ammonia-lyase (PAL) is a key enzyme catalyzing the conversion of L-phenylalanine into trans-cinnamic acid and plays a crucial role in plant secondary metabolism and stress responses. However, the enzymatic functions of PAL proteins in Chinese chestnut remain largely unexplored. In this study, we characterized four CmPAL proteins encoded in the chestnut genome through phylogenetic analysis, chromosomal localization, protein structure, and promoter cis-element identification. Enzyme activity assays and transcript profiling revealed distinct expression patterns among the CmPAL genes, with CmPAL1 showing the highest expression in roots, whereas CmPAL2, CmPAL3, and CmPAL4 showed relatively high expression in old leaves and low expression in kernels. To validate their enzymatic functions, CmPAL1 and CmPAL2 were transiently overexpressed in Nicotiana benthamiana and heterologously expressed in Escherichia coli BL21. Both approaches confirmed their ability to catalyze the conversion of L-phenylalanine into trans-cinnamic acid. Additionally, enzyme activity and transcript levels of CmPAL genes were significantly induced under abiotic stresses (drought, cold, heat, and salt), hormonal treatments methyl jasmonate (MeJA) and salicylic acid (SA), and Blumeria farreri (Bf) infection. Notably, CmPAL activity and expression were significantly higher in Bf-infected samples treated with 10 mM MeJA than with either treatment alone, suggesting an additive effect in enhancing PAL-mediated defense responses. Overall, our findings indicate that CmPAL1 and CmPAL2 are involved in phenylpropanoid metabolism and may contribute to powdery mildew resistance through MeJA signaling.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"364 ","pages":"152360"},"PeriodicalIF":8.5,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and characterization of lignin-modified defective UiO-66-NH₂ for enhanced curcumin adsorption and controlled release in drug delivery applications. 木质素修饰缺陷uio -66- nh2的合成与表征，增强姜黄素在药物传递中的吸附与控释。

IF 8.5 1区化学

International Journal of Biological Macromolecules Pub Date : 2026-05-02 DOI: 10.1016/j.ijbiomac.2026.152358

Ariadna Lopez Ortega, Habibollah Bahman, Hossein Kazemian, Hoorieh Djahaniani

{"title":"Synthesis and characterization of lignin-modified defective UiO-66-NH₂ for enhanced curcumin adsorption and controlled release in drug delivery applications.","authors":"Ariadna Lopez Ortega, Habibollah Bahman, Hossein Kazemian, Hoorieh Djahaniani","doi":"10.1016/j.ijbiomac.2026.152358","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.152358","url":null,"abstract":"This study explores the synthesis and characterization of modulated UiO-66 metal-organic frameworks (MOFs) to enhance curcumin adsorption and controlled release. UiO-66 was synthesized using solvothermal methods with varying linkers and modulating agents to produce non-modulated, defective, and lignin-incorporated variants. Specifically, frameworks were developed using different ratios of terephthalic acid (BDC) and 2-aminoterephthalic acid (ABDC), and lignin was incorporated into a selected defective UiO-66 variant to evaluate its effect on curcumin loading and release. The non-modulated UiO-66 (UiO-66-NM) served as a baseline, while defective UiO-66 samples were prepared with different BDC/ABDC ratios using trifluoroacetic acid (TFA) as a modulator. Among these, UiO-66-D (UiO-66 with 25% ABDC, 75% BDC, and TFA) and its lignin-modified version, L-UiO-66-D (UiO-66 with 25% ABDC, 75% BDC, TFA, and lignin at 10 wt% relative to the combined mass of metal salt and organic linkers), demonstrated superior properties. Curcumin (Cur) loading into L-UiO-66-D was optimized by varying the UiO-66 amount while keeping curcumin and ethanol concentrations constant, achieving a maximum adsorption efficiency of 91.38% and a loading capacity of 49.17 mg g-1. Release studies were conducted in phosphate-buffered saline (PBS) at 37 °C at different pH levels (1.2, 6.8, and 7.4), where both UiO-66-D and L-UiO-66-D exhibited controlled release behavior over 24 h. Characterization through FT-IR, XRD, SEM, TGA, and BET confirmed successful synthesis and provided insights into the structural and morphological properties of the MOFs. The results highlight the potential of modulating and functionalizing UiO-66 frameworks to improve performance in controlled drug-delivery applications.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"364 ","pages":"152358"},"PeriodicalIF":8.5,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0