International Journal of Biological Macromolecules最新文献_第3页

PTPN2: Advances and perspectives in cancer treatment potential and inhibitor research PTPN2：肿瘤治疗潜力及抑制剂研究进展与展望

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-05-27 DOI: 10.1016/j.ijbiomac.2025.144740

Yaru Zhang , Xiaocui Shuai , Yang Lei , Tingnan Ma , Tao Yuan , Shaomin Zhu , Lei Zhong

{"title":"PTPN2: Advances and perspectives in cancer treatment potential and inhibitor research","authors":"Yaru Zhang , Xiaocui Shuai , Yang Lei , Tingnan Ma , Tao Yuan , Shaomin Zhu , Lei Zhong","doi":"10.1016/j.ijbiomac.2025.144740","DOIUrl":"10.1016/j.ijbiomac.2025.144740","url":null,"abstract":"<div><div>Protein tyrosine phosphatase non-receptor 2 (PTPN2) is a well-established protein tyrosine phosphatase (PTP) that counterbalances protein tyrosine kinases (PTKs) activity by dephosphorylating tyrosine residues. Accumulating evidence demonstrates that dysregulated PTPN2 expression or activity regulates cancer biology, drives immune evasion, and confers resistance to immune checkpoint blockade therapy, establishing it as a compelling therapeutic target for cancer immunotherapy. Mechanistically, PTPN2 exerts immunosuppressive effects by dephosphorylating and negatively regulating immune response signaling, thereby dampening antitumor immunity and fostering an immunosuppressive tumor microenvironment. Recent breakthroughs in PTPN2 inhibitor development, such as small molecules, natural compounds, and PROTAC degraders, have shown promising efficacy in restoring immune-mediated tumor control. However, the anti-tumor therapy targeting PTPN2 still faces challenges, including its controversial role in some tumors, potential side effects, and the lack of highly effective and selective antagonists. In this comprehensive review, we synthesize the crucial functions of PTPN2 in tumor progression and immune regulation, systematically present the latest research progress of PTPN2 inhibitors, critically analyze unresolved hurdles in drug development, and provide strategic perspectives on addressing these challenges, with the hope of accelerating the clinical translation of PTPN2-targeted therapy from bench to bedside.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"316 ","pages":"Article 144740"},"PeriodicalIF":7.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative unsaturated polyurethane for cardiac regeneration: Enhancing cytocompatibility and gene expression through gelatin modification 用于心脏再生的创新不饱和聚氨酯：通过明胶修饰增强细胞相容性和基因表达

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-05-27 DOI: 10.1016/j.ijbiomac.2025.144659

Reza Behnam , Mohammad Dinari , Tayebeh Behzad

{"title":"Innovative unsaturated polyurethane for cardiac regeneration: Enhancing cytocompatibility and gene expression through gelatin modification","authors":"Reza Behnam , Mohammad Dinari , Tayebeh Behzad","doi":"10.1016/j.ijbiomac.2025.144659","DOIUrl":"10.1016/j.ijbiomac.2025.144659","url":null,"abstract":"<div><div>Developing a biomimetic platform that can effectively support myocardial repair and regeneration after a heart attack remains a major challenge for researchers. Polyurethanes (PU), known for their versatile properties, are increasingly being recognized as promising materials for creating cardiac patches. This research study developed the synthesis of a novel unsaturated chain extender via the Baylis-Hillman reaction for incorporation into the backbone of PU to create the unsaturated bridge for post-modification response. Thiol-ene chemistry performed post-modification of unsaturated hard domains of PU with thiolated gelatin as another reactant. Modification of the hard segment domains of PU with gelatin can have a synergistic effect on fabricating a new platform for repairing cardiac tissue. The films were characterized by Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR), Nuclear Magnetic Resonance (NMR), mechanical tests, in vitro degradation rate, water contact angle measurement, and swelling measurement. Metabolic activity and cytocompatibility of the cells onto the films were assessed by MTT assay. An investigation of cardiac-specific marker expression was conducted using immunofluorescence staining and quantitative real-time PCR. The findings showed that none of the substances were cytotoxic to cardiomyocytes, and that the expression of cadiac-specific genes, such as Troponin T, GATA4, Connexin43, and Alpha-SMA, was higher than that of the control group.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"316 ","pages":"Article 144659"},"PeriodicalIF":7.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellulose nanocrystal-based intelligent hydrogels: Innovations, challenges, and prospective application in advanced wound healing 基于纤维素纳米晶体的智能水凝胶：创新、挑战和在高级伤口愈合中的应用前景

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-05-27 DOI: 10.1016/j.ijbiomac.2025.144752

Saah Siaffa Martin , Lu Gan , Lingli Zhang , Xurui Yang , Zhongbiao Tan , Hao Shi , Lingfeng Long , Hongliang Li

{"title":"Cellulose nanocrystal-based intelligent hydrogels: Innovations, challenges, and prospective application in advanced wound healing","authors":"Saah Siaffa Martin , Lu Gan , Lingli Zhang , Xurui Yang , Zhongbiao Tan , Hao Shi , Lingfeng Long , Hongliang Li","doi":"10.1016/j.ijbiomac.2025.144752","DOIUrl":"10.1016/j.ijbiomac.2025.144752","url":null,"abstract":"<div><div>Cellulose nanocrystals (CNCs) have emerged as a transformative material in biomedical engineering due to their exceptional mechanical properties, high aspect ratio, and biocompatibility. Recent advances in CNC-based smart hydrogels show great potential in wound care through responsive drug delivery, moisture retention, and infection control. This review critically evaluates CNC-reinforced hydrogels' synthesis, functionalization, and biomedical applications, emphasizing their role in addressing chronic wound healing challenges. Despite promising results, clinical use is limited by scalability, cost, and long-term biocompatibility. Future research should optimize sustainable CNC extraction, integrate smart sensing, and explore cellular mechanisms. Collaboration with industry and pilot projects will provide insights, while workshops can train professionals in smart sensing and CNC optimization. Incorporating Internet of Things (IoT) sensors in CNC machines enables real-time monitoring of key parameters like temperature, vibration, and tool wear, facilitating predictive maintenance and process optimization through data analytics. Developing closed-loop control systems to adjust machining parameters based on real-time data enhances precision and reduces waste. CNC extraction optimization should include determining ideal process parameters, exploring advanced tooling materials, and using simulation software to streamline machining processes. This comprehensive analysis underscores the potential of CNC-based hydrogels to redefine regenerative medicine and personalized wound care.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"316 ","pages":"Article 144752"},"PeriodicalIF":7.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal relationship between 91 circulating inflammatory proteins and gynecological diseases: A two-sample bidirectional Mendelian randomization study 91种循环炎症蛋白与妇科疾病的因果关系：一项双样本双向孟德尔随机研究

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-05-27 DOI: 10.1016/j.ijbiomac.2025.144729

Jie-Lin Wang , Ping-An Zhang , Jing Yuan , Xiang-Chun Huang , Jia-Chen Cheng , Hai-Juan Bao , Jing Li , Shuo Chen

{"title":"Causal relationship between 91 circulating inflammatory proteins and gynecological diseases: A two-sample bidirectional Mendelian randomization study","authors":"Jie-Lin Wang , Ping-An Zhang , Jing Yuan , Xiang-Chun Huang , Jia-Chen Cheng , Hai-Juan Bao , Jing Li , Shuo Chen","doi":"10.1016/j.ijbiomac.2025.144729","DOIUrl":"10.1016/j.ijbiomac.2025.144729","url":null,"abstract":"<div><div>Gynecological diseases pose major public health challenges due to their detrimental impact on women's quality of life and fertility. While growing evidence implicates inflammatory proteins in the pathogenesis of these conditions, their causal roles remain unclear. In this study, we conducted a bidirectional two-sample Mendelian randomization (TSMR) analysis to explore causal relationships between 91 circulating inflammatory proteins and 17 gynecological diseases in a discovery cohort. We identified nine protein–disease pairs with potential causal associations, three of which remained significant after Bonferroni correction, including IL-1α with increased risk of cervical cancer, MMP10 with reduced risk of endometrial cancer, and MCP-1 with increased susceptibility to ovarian benign neoplasms. A meta-analysis incorporating data from an independent replication cohort further suggested that IL-1α increases the risk of cervical cancer. To validate these findings, we performed transcriptomic analysis using the TCGA database and confirmed protein-level expression through Western blot analysis of clinical samples. Collectively, these results provide novel insights into the inflammatory mechanisms underlying gynecological diseases and underscore IL-1α as a promising causal biomarker and potential therapeutic target for cervical cancer.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"316 ","pages":"Article 144729"},"PeriodicalIF":7.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal-polyphenol nanoparticles-loaded carboxymethyl cellulose-based microneedle for promoting the healing of diabetic wounds 金属多酚纳米颗粒负载羧甲基纤维素微针促进糖尿病伤口愈合

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-05-27 DOI: 10.1016/j.ijbiomac.2025.144716

Miaoyan Ren , Nan Wang , Liuyan Pu , Xiao-kun Ouyang , Jingfei Mao

{"title":"Metal-polyphenol nanoparticles-loaded carboxymethyl cellulose-based microneedle for promoting the healing of diabetic wounds","authors":"Miaoyan Ren , Nan Wang , Liuyan Pu , Xiao-kun Ouyang , Jingfei Mao","doi":"10.1016/j.ijbiomac.2025.144716","DOIUrl":"10.1016/j.ijbiomac.2025.144716","url":null,"abstract":"<div><div>Inflammation and infection are significant barriers to the healing of diabetic wounds. Infectious wounds are often associated with the formation of bacterial biofilms, which impede the penetration of conventional drugs. In this study, we developed a novel metal-polyphenol composite nanoparticle (EGCG-Cu<sup>2+</sup> NPs) by combining epigallocatechin gallate (EGCG) with Cu<sup>2+</sup> and incorporated these nanoparticles into microneedles (MNs) made from polyvinylpyrrolidone (PVP) and sodium carboxymethyl cellulose (CMC<img>Na). The resulting EGCG-Cu<sup>2+</sup> MNs exhibited remarkable anti-inflammatory and antibacterial properties, achieving over 95 % inhibition against <em>S. aureus</em> and <em>P. aeruginosa</em>. Moreover, they effectively scavenged reactive oxygen species (ROS), inhibited the M1 polarization of macrophages, and promoted their M2 polarization. In diabetic wound infection models, the EGCG-Cu<sup>2+</sup> MNs enhanced collagen deposition and angiogenesis, resulting in over 92 % wound closure within 14 days. This study provides a significant theoretical basis for innovative treatment strategies for infectious diabetic wounds, highlighting its promising clinical application potential.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"316 ","pages":"Article 144716"},"PeriodicalIF":7.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Archaeal tyrosinase as a versatile biocatalyst for lignin-derived aromatic compounds valorization 古生菌酪氨酸酶作为木质素衍生芳香化合物增值的多功能生物催化剂

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-05-27 DOI: 10.1016/j.ijbiomac.2025.144669

Seul Hoo Lee , Eungsu Kang , Yoo Seong Choi , Kyung-Jin Kim

{"title":"Archaeal tyrosinase as a versatile biocatalyst for lignin-derived aromatic compounds valorization","authors":"Seul Hoo Lee , Eungsu Kang , Yoo Seong Choi , Kyung-Jin Kim","doi":"10.1016/j.ijbiomac.2025.144669","DOIUrl":"10.1016/j.ijbiomac.2025.144669","url":null,"abstract":"<div><div>Biomass-derived aromatic compounds, including those obtained from lignin (which is the most abundant aromatic biopolymer on Earth), are valuable for sustainable chemical production. Various lignin-degrading approaches have been developed to cleave recalcitrant bonds. The incorporation of biocatalysts that operate under environmentally friendly and mild conditions with high substrate specificity is considered one of the emerging strategies for lignin valorization. In this study, an archaeal tyrosinase (Tyr-CNK), derived from the marine archaeon <em>Candidatus nitrosopumilus koreensis</em>, is characterized as a versatile biocatalyst for lignin biodegradation and valorization, based on kinetic studies, protein structure determination, and analysis. Notably, the extremely shallow active site pocket and the unique noncanonical caddy domain, which facilitate efficient copper incorporation without obstructing the active site, collectively empower Tyr-CNK with remarkable catalytic efficiency toward various lignin model compounds, such as <em>p</em>-coumaric acid, 4-phenoxyphenol, 4-(benzyloxy)phenol, and guaiacyl glycerol-β-guaiacyl ether. Together with molecular docking simulations, these catalytic and structural features indicate that Tyr-CNK serves as an efficient biocatalyst for the hydroxylation and oxidative degradation of lignin-derived phenolic compounds. Given its versatility, efficiency, and structural uniqueness, Tyr-CNK demonstrates great promise for expanding the catalytic repertoire for biomass conversions and offering new opportunities in sustainable biocatalysis, enzymatic and microbial biodegradation and biomass valorization.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"316 ","pages":"Article 144669"},"PeriodicalIF":7.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellulose gels with controllable oriented porous structure by regulating regeneration process 可调控再生过程的定向多孔结构纤维素凝胶

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-05-27 DOI: 10.1016/j.ijbiomac.2025.144753

Tongping Zhang , Cheng Cheng , Gang Wei , Xiaofang Zhang , Jianming Zhang

{"title":"Cellulose gels with controllable oriented porous structure by regulating regeneration process","authors":"Tongping Zhang , Cheng Cheng , Gang Wei , Xiaofang Zhang , Jianming Zhang","doi":"10.1016/j.ijbiomac.2025.144753","DOIUrl":"10.1016/j.ijbiomac.2025.144753","url":null,"abstract":"<div><div>The processing of raw cellulose materials to biomimetic regenerated cellulose materials with oriented porous structures is crucial for mimicking multiscale oriented porous structures of natural organisms. However, it remains challenging to understand how the cellulose/ionic liquid (IL) solution interacts with non-solvent water to regenerate and form oriented porous channels. Additionally, broadening the range of controllable pore sizes presents significant difficulties. This study explores the role of temperature in the controlled regeneration of cellulose chains using ILs solvents to create oriented porous structures. By manipulating the temperature of the regeneration bath in the range of 2–60 °C, we successfully regulate the self-assembly of cellulose molecules, achieving precise control over the sizes of the oriented pores. Our approach enables pore size tuning within a range of 0.05 to 1 mm, effectively addressing the challenge of limited pore size variability. This research highlights the critical influence of temperature on the phase separation process and its subsequent impact on the formation of oriented pores. This advancement opens new possibilities for designing sustainable, cellulose-based materials with tailored functionalities for advanced applications in environmental and biomedical engineering.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"316 ","pages":"Article 144753"},"PeriodicalIF":7.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of neem-oil-loaded PVA/chitosan biocomposite film for hydrophobic dressing, rapid hemostasis and wound healing applications 尼姆油负载PVA/壳聚糖生物复合膜在疏水敷料、快速止血和伤口愈合中的应用研究

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-05-27 DOI: 10.1016/j.ijbiomac.2025.144712

Md. Hasinur Rahman, Md. Ibrahim H. Mondal

{"title":"Investigation of neem-oil-loaded PVA/chitosan biocomposite film for hydrophobic dressing, rapid hemostasis and wound healing applications","authors":"Md. Hasinur Rahman, Md. Ibrahim H. Mondal","doi":"10.1016/j.ijbiomac.2025.144712","DOIUrl":"10.1016/j.ijbiomac.2025.144712","url":null,"abstract":"<div><div>The present work aims to develop a hydrophobic dressing with a blood-repellent surface that achieves fast clotting without blood loss, having antibacterial properties, clot self-detachment, and superior wound healing activity. For these reasons, a novel approach was applied by producing a hydrophobic film made of PVA, chitosan, and neem seed oil (NSO). The film had the necessary hydrophobicity, mechanical strength, stability and was able to transmit water vapor to be suitable for the wound skin surface and demonstrated faster blood clotting (BCI = 91.44 % in 5 min and 85.22 % in 10 min). The proportion of red blood cells (2.78 %) and platelets (17.33 %) attached to the film proved its excellent hemostatic activity. It was anti-adhesive, created spontaneous clot detachment, and exhibited antibacterial properties at the wound site, as evidenced by in vivo testing. Moreover, in vivo testing and histopathological findings showed enhanced wound healing activity, greater re-epithelialization, and decreased granulation tissue. Additionally, the film's eco-friendliness was evaluated using a soil burial degradation test, and the results show that it deteriorated into the soil but did so slowly because of its hydrophobic property. Thus, PVA/CS/NSO composite film may be a green biomedical material for hemostasis and wound healing.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"316 ","pages":"Article 144712"},"PeriodicalIF":7.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The critical role of transcription factor GATA1 in erythrocyte proliferation and morphology in blood clam Anadara granosa 转录因子GATA1在血蛤红细胞增殖和形态中的关键作用

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-05-27 DOI: 10.1016/j.ijbiomac.2025.144691

Jiacheng Wang , Yuhang Zhang , Yingbin Xu , Hongyu Jin , Can Yang , Hongxing Liu , Yongbo Bao

{"title":"The critical role of transcription factor GATA1 in erythrocyte proliferation and morphology in blood clam Anadara granosa","authors":"Jiacheng Wang , Yuhang Zhang , Yingbin Xu , Hongyu Jin , Can Yang , Hongxing Liu , Yongbo Bao","doi":"10.1016/j.ijbiomac.2025.144691","DOIUrl":"10.1016/j.ijbiomac.2025.144691","url":null,"abstract":"<div><div>The blood clam (<em>Anadara granosa</em>) exhibits innovative red blood compared to other molluscs, with erythrocytes constituting 79 % to 89 % of the total hemocyte count. Previously, we identified that GATA-binding protein 1 (designated as <em>Ag</em>GATA1) was significantly up-regulated in the transcriptomes of blood clam populations with high hemocyte counts. However, the function of <em>Ag</em>GATA1 in erythropoiesis remains unknown. In this study, we conducted GATA1 knockdown experiments in <em>A. granosa</em>, which resulted in a significant reduction of both erythrocytes and other cells during the S phase, as well as significantly decreased proliferative activity in the gill tissue. The cell proliferation assay demonstrated that overexpression of <em>Ag</em>GATA1 increased the DNA replication activity of K562 cells. Additionally, o-dianisidine staining revealed defects in erythropoiesis within the gill tissue following <em>Ag</em>GATA1 knockdown, while protein analyses confirmed a significant reduction in <em>Ag</em>GATA1 expression. Furthermore, decreased cytoskeletal fluorescence and morphological changes in erythrocytes suggest that <em>Ag</em>GATA1 influenced cytoskeletal protein expression, leading to changes in erythrocyte morphology. This study provides new insights into the role of <em>Ag</em>GATA1 in hemocyte formation and highlights its significance in understanding erythropoiesis within invertebrate developmental tissues.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"315 ","pages":"Article 144691"},"PeriodicalIF":7.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual cross-linked network cyclodextrin-based aerogel with enhanced green flame-retardant and noise reduction properties 基于环糊精的双交联网络气凝胶，具有增强的绿色阻燃和降噪性能

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-05-27 DOI: 10.1016/j.ijbiomac.2025.144711

Jia-Xin Wang , Haoran Xu , Ye-Tao Zhang , Dong-Lin Guo , Bang-Jing Li , Sheng Zhang

{"title":"Dual cross-linked network cyclodextrin-based aerogel with enhanced green flame-retardant and noise reduction properties","authors":"Jia-Xin Wang , Haoran Xu , Ye-Tao Zhang , Dong-Lin Guo , Bang-Jing Li , Sheng Zhang","doi":"10.1016/j.ijbiomac.2025.144711","DOIUrl":"10.1016/j.ijbiomac.2025.144711","url":null,"abstract":"<div><div>Biomass porous materials, such as polysaccharides, possess significant potential across various domains due to their unique physical properties. However, the flammability and inadequate noise reduction capabilities of these eco-friendly porous materials restrict their applications in practical conditions. Herein, polysaccharides such as cyclodextrin (CD), sodium alginate (Alg), and phytic acid (PA) were utilized as raw materials to prepare PCD/Alg/PA aerogels through a simple freeze-drying technique. The incorporation of PA not only facilitates the formation of char layers for flame retardancy, but also fortifies the development of a dual physical–chemical cross-linking network, which in turn bolsters enhanced properties. The resultant PCD/Alg/PA aerogels exhibit exceptional flame resistance, featuring a high limiting oxygen index (LOI) of 50.7 % and a low total heat release (THR) of 0.7 MJ/m<sup>2</sup>. The PCD/Alg/PA aerogels exhibit a maximum compression modulus of 2.8 MPa, demonstrating excellent mechanical properties. Meanwhile, the combination of the nano-cavities of CDs with the enriched hierarchical porous structure in PCD/Alg/PA aerogels leads to superior noise reduction capabilities, with sound absorption coefficients exceeding 0.85 in the frequency range of 1200–6400 Hz. Utilizing a simple and scalable method, the prepared biomass PCD/Alg/PA aerogels exhibit superior flame retardancy and noise reduction performance, thereby advancing the development of environmentally friendly materials.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"316 ","pages":"Article 144711"},"PeriodicalIF":7.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0