International Journal of Biological Macromolecules最新文献_第4页

Lectin from microalgae: Non-toxic to human cells and effective against Leishmania. 微藻凝集素：对人体细胞无毒，对利什曼原虫有效。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-02-01 Epub Date: 2024-12-13 DOI: 10.1016/j.ijbiomac.2024.138630

Alexsandra Frazão de Andrade, Sabrina Swan Souza da Silva, Dayane Rodrigues da Silva, Millena Patricio do Nascimento Ferreira, Maria Gabriella Nunes de Melo, Marllyn Marques da Silva, Mariane Cajubá de Britto Lira-Nogueira, Daniela de Araújo Viana-Marques, Teresinha Gonçalves da Silva, Ana Lúcia Figueiredo Porto, Milena de Paiva-Cavalcanti, Raquel Pedrosa Bezerra

{"title":"Lectin from microalgae: Non-toxic to human cells and effective against Leishmania.","authors":"Alexsandra Frazão de Andrade, Sabrina Swan Souza da Silva, Dayane Rodrigues da Silva, Millena Patricio do Nascimento Ferreira, Maria Gabriella Nunes de Melo, Marllyn Marques da Silva, Mariane Cajubá de Britto Lira-Nogueira, Daniela de Araújo Viana-Marques, Teresinha Gonçalves da Silva, Ana Lúcia Figueiredo Porto, Milena de Paiva-Cavalcanti, Raquel Pedrosa Bezerra","doi":"10.1016/j.ijbiomac.2024.138630","DOIUrl":"10.1016/j.ijbiomac.2024.138630","url":null,"abstract":"New leishmanicidal products are needed for the treatment to be effective, since current drugs are toxic to healthy human/animal cells and have low efficacy against the parasite. Bioactive compounds from microalgae, such as lectins, can be explored as new anti-Leishmania candidates. This study aimed to evaluate the cytotoxic and anti-Leishmania action of the cell extract (CE) and lectin (CVU) from Chlorella vulgaris biomass. CVU purified from CE was stable within alkaline pH and temperature below 50 °C. CVU showed specificity to the carbohydrate D-Galactose, which is found in the membrane of Leishmania. CE (IC50 = 161.4 μg/mL) and CVU (IC50 = 66.32 μg/mL) exhibited effects against the promastigotes of L. braziliensis, and scanning electron microscopy confirmed alterations the shape and size in treated parasites. CE showed a higher selectivity index than CVU on L. braziliensis promastigotes. These results demonstrate the potential of C. vulgaris as a source of active molecules that can be investigated as therapeutic candidates.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138630"},"PeriodicalIF":7.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteomics of the shell matrix proteins and functional analysis of Am13 and AmKaSPI from the shell of Archivesica marissinica. 海参壳基质蛋白的蛋白质组学及Am13和AmKaSPI的功能分析。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-02-01 Epub Date: 2024-12-13 DOI: 10.1016/j.ijbiomac.2024.138767

Dongting Liu, Yongyi Lin, Maoxian He, Yu Shi

{"title":"Proteomics of the shell matrix proteins and functional analysis of Am13 and AmKaSPI from the shell of Archivesica marissinica.","authors":"Dongting Liu, Yongyi Lin, Maoxian He, Yu Shi","doi":"10.1016/j.ijbiomac.2024.138767","DOIUrl":"10.1016/j.ijbiomac.2024.138767","url":null,"abstract":"Archivesica marissinica is a dominant species inhabiting the Haima cold seep in the South China Sea. However, the composition, characterization and specific functions of conserved and unique shell matrix proteins (SMPs) in A. marissinica remain unknown. This study identified 266 shell matrix proteins in A. marissinica. Among them, two conserved SMPs, AmSMP1 protein and Pif-like protein were identified. We have discovered a novel SMP, named Am13, and a highly expressed SMP with a Kazal domain, named AmKaSPI. qPCR analysis revealed Am13 and AmKaSPI are highly expressed in the mantle. Am13 negatively regulated calcite formation and positively regulated aragonite formation. High concentrations of Am13 inhibit aragonite size growth and increase aragonite abundance, possibly due to the limited availability of calcium ions in the deep sea. AmKaSPI positively regulates the formation of both calcite and aragonite by enhancing the nucleation and aggregation and inducing morphology changes in CaCO3 crystals. AmKaSPI promotes the morphological changes in calcite, forming a cross-shaped star structure, which may the key SMP shaped the \"chrysanthemum\"-like formation of prism layer. AmKaSPI may facilitate shell formation in A. marissinica in special environments. These findings contribute to a deeper understanding of the composition and characteristics of SMPs in deep-sea clam.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138767"},"PeriodicalIF":7.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Anionic surfactant effect on the structural and thermal insulation properties of crosslinked-cellulose nanofiber foam and its superhydrophobic treatment" [International Journal of Biological Macromolecules, 283 (2024) 137934]. “阴离子表面活性剂对交联纤维素纳米纤维泡沫结构和绝热性能的影响及其超疏水处理”[j].国际高分子学报，28(2024):137934。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-02-01 Epub Date: 2024-12-14 DOI: 10.1016/j.ijbiomac.2024.138677

Dinesh, Hanbin Wang, Duc Hoa Pham, Jaehwan Kim

引用次数: 0

BATF2/SINHCAF regulates the quantity and function of macrophages infected with Mycobacterium Tuberculosis via regulation of TTC23 through Wnt/β-catenin pathway. BATF2/SINHCAF通过Wnt/β-catenin通路通过调控TTC23调控感染结核分枝杆菌的巨噬细胞的数量和功能。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-02-01 Epub Date: 2024-12-11 DOI: 10.1016/j.ijbiomac.2024.138639

Jie Zhou, Kun-Long Xiong, Hong-Xiu Wang, Wen-Wen Sun, Hui Ke, Shao-Jun Zhang, Zheng-Wei Dong, Lin Fan

{"title":"BATF2/SINHCAF regulates the quantity and function of macrophages infected with Mycobacterium Tuberculosis via regulation of TTC23 through Wnt/β-catenin pathway.","authors":"Jie Zhou, Kun-Long Xiong, Hong-Xiu Wang, Wen-Wen Sun, Hui Ke, Shao-Jun Zhang, Zheng-Wei Dong, Lin Fan","doi":"10.1016/j.ijbiomac.2024.138639","DOIUrl":"10.1016/j.ijbiomac.2024.138639","url":null,"abstract":"Elucidating the pathogenic mechanism of Tuberculosis (TB) can contribute to control TB. Basic leucine zipper transcription factor ATF-like 2 (BATF2) belonging to a large family of leucine zipper transcription factors (TFs) termed bZip proteins, had been verified to have important value in the diagnosis of TB. However, its role and mechanism in TB had not been elucidated. The study aimed to explore its function and molecular mechanism in macrophages infected with Mycobacterium tuberculosis (Mtb). The results indicated that BATF2 inhibited cell proliferation, promoted inflammatory response and impaired the antibacterial and antigen-presenting capacity in macrophages for T cells through regulating its downstream gene TTC23 by interacting with SINHCAF. Above roles and regulations were dependent on β-catenin functions in macrophages infected with Mtb. Clinical samples verified that the expressions of BATF2 and TTC23 were significantly higher in the blood of patients with pulmonary TB compared with health controls. Altogether, BATF2 interacted with SINHCAF to regulate the quantity and function of macrophages during Mtb infection by targeting TTC23 through Wnt/β-catenin pathway.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138639"},"PeriodicalIF":7.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of composite chitosan/algae/zeolite by freeze- or air-drying: A comparative adsorbent analysis for optimized removal of brilliant green dye. 通过冷冻或空气干燥设计壳聚糖/藻类/沸石复合吸附剂：优化去除艳绿染料的吸附剂对比分析

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-02-01 Epub Date: 2024-12-18 DOI: 10.1016/j.ijbiomac.2024.138650

Aiman Suhaimi, Ali H Jawad, Mohd Zaki Mohd Yusoff, Lee D Wilson, Zeid A ALOthman

{"title":"Design of composite chitosan/algae/zeolite by freeze- or air-drying: A comparative adsorbent analysis for optimized removal of brilliant green dye.","authors":"Aiman Suhaimi, Ali H Jawad, Mohd Zaki Mohd Yusoff, Lee D Wilson, Zeid A ALOthman","doi":"10.1016/j.ijbiomac.2024.138650","DOIUrl":"10.1016/j.ijbiomac.2024.138650","url":null,"abstract":"A bio-composite material was developed that contains chitosan, food-grade algae, and zeolite for the removal of brilliant green (BG) dye. The synthesized bio-composite was dried via two different methods (air-drying; AD, and freeze-drying; FD). The physicochemical characterization of air-dried chitosan-algae-zeolite (Cs-Alg-Zl-AD) and freeze-dried chitosan-algae-zeolite (Cs-Alg-Zl-FD) were investigated by spectroscopy (FTIR, SEM-EDX, and XPS), diffraction (XRD), surface charge via pHpzc, specific surface area (SSA) and elemental analyses. The utilization of Box-Behnken Design (BBD) was intended to optimize the three input variables, which are adsorbent dosage, pH of medium, and contact time. The adsorption optimization process yielded optimal conditions, which were verified through a desirability test and implemented in batch-mode equilibrium experiments. The Cs-Alg-Zl-FD has a higher specific surface area (SSA = 3.29 m2/g) compared to Cs-Alg-Zl-AD (SSA = 1.79 m2/g). The Cs-Alg-Zl-FD shows greater adsorptive removal of BG (98.6 %) over Cs-Alg-Zl-AD (88.6 %), in parallel agreement with differences in the SSA. Moreover, the maximum BG dye adsorption capacities of Cs-Alg-Zl-FD (119.5 mg/g) and Cs-Alg-Zl-AD (108 mg/g) at pH = 8.1 and 25 °C. The Freundlich model fits best with Cs-Alg-Zl-AD while Langmuir and Temkin models account for the Cs-Alg-Zl-FD dye adsorption. The Cs-Alg-Zl-FD shows greater dye adsorption over four adsorption cycles, as compared with the Cs-Alg-Zl-AD.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138650"},"PeriodicalIF":7.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adsorption mechanism of key off-odor compounds of oyster peptide by V-type starch in the solid-phase environment. v型淀粉在固相环境下对牡蛎肽主要恶臭化合物的吸附机理。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-02-01 Epub Date: 2024-12-04 DOI: 10.1016/j.ijbiomac.2024.138399

Linfan Shi, Yaolin Dai, Peichao Chen, Zhongyang Ren, Ping Li, Wuyin Weng

{"title":"Adsorption mechanism of key off-odor compounds of oyster peptide by V-type starch in the solid-phase environment.","authors":"Linfan Shi, Yaolin Dai, Peichao Chen, Zhongyang Ren, Ping Li, Wuyin Weng","doi":"10.1016/j.ijbiomac.2024.138399","DOIUrl":"10.1016/j.ijbiomac.2024.138399","url":null,"abstract":"V-type starch was employed to adsorb key off-odors (heptanal and 1-octen-3-ol) of oyster peptide (OP), and the adsorption mechanism was investigated. The off-odor content was quantified using gas chromatography (GC), and the successful inclusion complexes (ICs) between the key off-odors of OP and V-type starches were detected by X-ray diffraction, differential scanning calorimetry, Fourier transform infrared (FTIR) spectroscopy, and X-ray photoelectron spectroscopy. In FTIR spectra, the appearance of new peaks and the shifts of characteristic peaks in ICs indicated the successful formation of ICs between V-type starches and heptanal or 1-octen-3-ol. The results of thermodynamic analysis showed that the endothermic peaks of ICs in the range of 113-116 °C corresponded to the formation of V-type II complexes. The GC results suggested that V6a- and V7a-type starches exhibited selective adsorption of heptanal and 1-octen-3-ol, respectively, which was attributed to the size compatibility between starches and guest molecules. Furthermore, the correlation analysis exhibited that the encapsulation efficiency and loading efficiency of V-type starches for heptanal and 1-octen-3-ol were correlated with the enthalpy, short-range order degree and relative crystallinity. The research findings demonstrate the good adsorption effects of V-type starches on characteristic off-odors of OP, which could effectively improve the flavor of OP.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138399"},"PeriodicalIF":7.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pivotal switch in β-domain determines the substrate selectivity of terpene synthases involved in Gardenia jasminoides floral scent synthesis. β-结构域的关键开关决定了栀子花香味合成中TPS基因的底物选择性。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-02-01 Epub Date: 2024-12-07 DOI: 10.1016/j.ijbiomac.2024.138333

Qizhen Chen, Menglan Wang, Longlong Gao, Qian Lou, Yutong Gan, Xinyao Li, Yanfei Li, Tianyi Xin, Wenjie Xu, Jingyuan Song

{"title":"A pivotal switch in β-domain determines the substrate selectivity of terpene synthases involved in Gardenia jasminoides floral scent synthesis.","authors":"Qizhen Chen, Menglan Wang, Longlong Gao, Qian Lou, Yutong Gan, Xinyao Li, Yanfei Li, Tianyi Xin, Wenjie Xu, Jingyuan Song","doi":"10.1016/j.ijbiomac.2024.138333","DOIUrl":"10.1016/j.ijbiomac.2024.138333","url":null,"abstract":"Plants have evolved a diverse array of secondary metabolites to enhance their adaptability to environmental stresses, with volatile terpenoids being a notable example. Gardenia (Gardenia jasminoides), celebrated for its unique fragrance, is a key natural source of volatile terpenoids. Using our chromosome-level genome and transcriptome data of G. jasminoides, we previously identified six terpene synthases (TPSs) involved in the production of its floral scent. Here, we functionally characterized these six key TPS enzymes, aligning their product profiles with volatile organic compound (VOC) analysis. Notably, we identified two highly similar TPSs, GjTPS1 and GjTPS2, which share high sequence homology but differ in substrate selectivity. Through AI-based predictions and site-directed mutagenesis, we pinpointed a single amino acid in the β-domain that acts as a \"switch,\" modulating substrate selectivity-an unusual finding, as this residue is outside the active site region. Comparative genomic analyses with Coffea canephora and other eudicots revealed that G. jasminoides TPS genes primarily expanded through dispersed duplications (DSD) and tandem duplications (TD). Our study is the first to reveal a \"switch\" in a previously deemed \"non-functional\" region, regulating substrate selectivity in TPS proteins. These insights could facilitate breeding elite Gardenia varieties and support the rational engineering of terpene synthases.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138333"},"PeriodicalIF":7.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MADS-box BSISTER transcription factors regulate stilbenes biosynthesis in grapes by directly binding to the promoter of STS48. MADS-box BSISTER转录因子通过直接结合STS48启动子调控葡萄中二苯乙烯的生物合成。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-02-01 Epub Date: 2024-12-09 DOI: 10.1016/j.ijbiomac.2024.138625

Yujin Tang, Huiqing Cheng, Congbo Huang, Ting Zhao, Yan Li, Chaohong Zhang

{"title":"MADS-box BSISTER transcription factors regulate stilbenes biosynthesis in grapes by directly binding to the promoter of STS48.","authors":"Yujin Tang, Huiqing Cheng, Congbo Huang, Ting Zhao, Yan Li, Chaohong Zhang","doi":"10.1016/j.ijbiomac.2024.138625","DOIUrl":"10.1016/j.ijbiomac.2024.138625","url":null,"abstract":"Stilbenes constitute a class of naturally occurring polyphenolic compounds that have been identified in a wide range of plants. In wine, stilbenes play crucial roles in humans, exhibiting anti-cancer, anti-inflammatory, antioxidant properties, and aiding in the prevention of cardiovascular diseases. Therefore, studies on the synthesis and regulatory mechanisms of styrene compounds in grapes are of great economic importance. In this study, we discovered that BS (BSISTER) transcript factors, a member of the MADS-BOX gene family, regulate the biosynthesis of stilbenes in grapevine. Comprehensive transcriptome and phenolic metabolome analysis were conducted on wild-type grapevine callus, as well as on transgenic callus overexpressing 35S::VviBS1-GFP and 35S: VviBS2-GFP under the control of the 35S promoter. The results showed that VviBS1 and VviBS2 down-regulate the synthesis of stilbenes. We screened seven STS differential genes from the transcriptome and further examined the expression of these differential genes in grapevine callus by RT-qPCR, and found that VviSTS48 was the most highly expressed compared to other STS genes. In addition, yeast one-hybrid assay, dual luciferase assay, and Chip-qPCR assay were performed for validation. The results of these experiments indicate that VviBS1 and VviBS2 down-regulate astragalus synthesis by directly binding to the promoter of VviSTS48. In conclusion, our researches provide new insight into the regulatory mechanisms of stilbenes biosynthesis in grapevine, which could be effectively employed for metabolic engineering to regulate stilbenes content and represent a useful reference for further study of BS function.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138625"},"PeriodicalIF":7.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extraction, purification, structural characterization, biological activity, mechanism of action and application of polysaccharides from Ganoderma lucidum: A review. 综述了灵芝多糖的提取纯化、结构表征、生物活性、作用机理及应用。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-02-01 Epub Date: 2024-12-09 DOI: 10.1016/j.ijbiomac.2024.138575

Ling Ding, Huizi Shangguan, Xin Wang, Jiping Liu, Yongheng Shi, Xinya Xu, Yundong Xie

{"title":"Extraction, purification, structural characterization, biological activity, mechanism of action and application of polysaccharides from Ganoderma lucidum: A review.","authors":"Ling Ding, Huizi Shangguan, Xin Wang, Jiping Liu, Yongheng Shi, Xinya Xu, Yundong Xie","doi":"10.1016/j.ijbiomac.2024.138575","DOIUrl":"10.1016/j.ijbiomac.2024.138575","url":null,"abstract":"Ganoderma lucidum is a traditional tonic medicine in China, known as the \"fairy grass\" and \"spiritual grass\". It contains various chemical components, such as polysaccharides, triterpenoids, alkaloids, nucleosides, sterols, and acid compounds, which have the effects of tonifying qi and calming the mind, stopping cough and asthma, and are used to treat restlessness, lung deficiency cough and asthma, fatigue and shortness of breath, and lack of appetite. Ganoderma lucidum polysaccharides (GLPs) are one of the main bioactive ingredients and are widely used in traditional Chinese medicine and traditional medicine fields. They have shown good medicinal value in enhancing immunity, inhibiting tumor cell growth, delaying aging, lowering blood sugar, lowering blood lipids, protecting the heart, anti-radiation, anti-fatigue, and other aspects. This article reviews the research progress on the extraction and purification, structural characteristics, pharmacological activity, and mechanisms of GLPs, as well as their applications in industries such as medicine, food, and daily chemical products. The aim is to provide theoretical basis for the treatment of traditional Chinese medicine compound preparations and lay the foundation for the potential value development of Ganoderma lucidum products.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138575"},"PeriodicalIF":7.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Administration time modify the anxiolytic and antidepressant effects of inulin via gut-brain axis. 给药时间通过肠脑轴改变菊粉的抗焦虑和抗抑郁作用。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-02-01 Epub Date: 2024-12-11 DOI: 10.1016/j.ijbiomac.2024.138698

Ping Chen, Fanyang Chen, Tao Hou, Xueqin Hu, Chenxing Xia, Jiaming Zhang, Shanshan Shen, Chunmei Li, Kaikai Li

{"title":"Administration time modify the anxiolytic and antidepressant effects of inulin via gut-brain axis.","authors":"Ping Chen, Fanyang Chen, Tao Hou, Xueqin Hu, Chenxing Xia, Jiaming Zhang, Shanshan Shen, Chunmei Li, Kaikai Li","doi":"10.1016/j.ijbiomac.2024.138698","DOIUrl":"10.1016/j.ijbiomac.2024.138698","url":null,"abstract":"An imbalance in the microbiota-gut-brain axis exerts an essential effect on the pathophysiology of depressive and anxiety disorders. Our previous research revealed that the timing of inulin administration altered its effects on chronic unpredictable mild stress (CUMS)-induced anxiety and depression. However, it is still unclear if the gut-brain axis is primarily responsible for these effects. In this study, fecal microbiota transplantation (FMT) confirmed that inulin administration at different times alleviated CUMS-induced anxiety- and depression-like behaviors via the gut-brain axis. The time of administration seemed to modify the anxiolytic and antidepressant effects of inulin, and inulin intervention in the evening was more pronounced in inhibiting the inflammatory responses than that of morning inulin intervention. Serum metabolomics analysis showed that the main differential metabolites, including fenofibric acid, 4'-Hydroxyfenoprofen glucuronide and 5-(4-Hydroxybenzyl)thiazolidine-2,4-dione may be vital for the anxiolytic and antidepressant effects of different inulin treatment times. Our results suggested that inulin administration in the evening was more effective in alleviating the inflammatory responses and improving amino acids metabolism. This study provides a new potential link between the microbiota-gut-brain axis and chrono-nutrition, demonstrating that a more appropriate administration time results in a better intervention effect.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138698"},"PeriodicalIF":7.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0