International Journal of Biological Macromolecules最新文献_第4页

Peptide-modified nanoparticles for doxorubicin delivery: Strategies to overcome chemoresistance and perspectives on carbohydrate polymers.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-01-22 DOI: 10.1016/j.ijbiomac.2025.140143

Xu Han, Xue Zhang, Longdan Kang, Shuai Feng, Yinyan Li, Ge Zhao

{"title":"Peptide-modified nanoparticles for doxorubicin delivery: Strategies to overcome chemoresistance and perspectives on carbohydrate polymers.","authors":"Xu Han, Xue Zhang, Longdan Kang, Shuai Feng, Yinyan Li, Ge Zhao","doi":"10.1016/j.ijbiomac.2025.140143","DOIUrl":"10.1016/j.ijbiomac.2025.140143","url":null,"abstract":"Chemotherapy serves as the primary treatment for cancers, facing challenges due to the emergence of drug resistance. Combination therapy has been developed to combat cancer drug resistance, yet it still suffers from lack of specific targeting of cancer cells and poor accumulation at the tumor site. Consequently, targeted administration of chemotherapy medications has been employed in cancer treatment. Doxorubicin (DOX) is one of the most frequently used chemotherapeutics, functioning by inhibiting topoisomerase activity. Enhancing the anti-cancer effects of DOX and overcoming drug resistance can be accomplished via delivery by nanoparticles. This review will focus on the development of peptide-DOX conjugates, the functionalization of nanoparticles with peptides, the co-delivery of DOX and peptides, as well as the theranostic use of peptide-modified nanoparticles in cancer treatment. The peptide-DOX conjugates have been designed to enhance the targeted delivery to cancer cells by interacting with receptors that are overexpressed on tumor surfaces. Moreover, nanoparticles can be modified with peptides to improve their uptake in tumor cells via endocytosis. Nanoparticles have the ability to co-deliver DOX along with therapeutic peptides for enhanced cancer treatment. Finally, nanoparticles modified with peptides can offer theranostic capabilities by facilitating both imaging and the delivery of DOX (chemotherapy).","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"140143"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143035577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enthalpy driven temperature-sensitive conformational changes in a metamorphic protein involved in the cyanobacterial circadian clock.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-01-26 DOI: 10.1016/j.ijbiomac.2025.140360

Buyuan Ma, Zengxin Ma, Ning Zhang

引用次数: 0

Sodium alginate/low methoxyl pectin composite hydrogel beads prepared via gas-shearing technology for enhancing the colon-targeted delivery of probiotics and modulating gut microbiota.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-01-26 DOI: 10.1016/j.ijbiomac.2025.140375

Fan Zhang, Xujiao Zheng, Ying Ma, Wuqiang Nan, Wenjing Wu, Ziru Chu, Xin Sun, Jihong Huang, Marat Muratkhan, Fangfang Yue, Xin Wang, Xin Lü

{"title":"Sodium alginate/low methoxyl pectin composite hydrogel beads prepared via gas-shearing technology for enhancing the colon-targeted delivery of probiotics and modulating gut microbiota.","authors":"Fan Zhang, Xujiao Zheng, Ying Ma, Wuqiang Nan, Wenjing Wu, Ziru Chu, Xin Sun, Jihong Huang, Marat Muratkhan, Fangfang Yue, Xin Wang, Xin Lü","doi":"10.1016/j.ijbiomac.2025.140375","DOIUrl":"10.1016/j.ijbiomac.2025.140375","url":null,"abstract":"The probiotic encapsulation system has the potential to enhance the prebiotic effects of probiotics. However, challenges arise from the release behavior of this system in vivo and the large size of hydrogel beads. This study aims to address the issues related to the size of previous hydrogel beads and assess the colon-targeted delivery of probiotic polysaccharides composite hydrogel beads (PPHB). PPHB prepared by gas-shearing technique significantly reduced the average particle size and demonstrated a high protective capacity for probiotics (after simulating intestinal conditions for 4 h, the viability of encapsulated probiotics remained at 107 CFU/g). The use of indocyanine green along with near-infrared-II in vivo imaging technology demonstrated the colon-targeted delivery of PPHB in vivo, which also extended the retention time of probiotics in the cecum and colon. Additionally, the colon-targeted delivery of PPHB was also demonstrated by dietary supplementation in vivo. PPHB significantly enhanced the diversity and richness of intestinal microflora species, increased the levels of short-chain fatty acids, raised the relative abundance of beneficial bacteria, and significantly decreased the relative abundance of harmful bacteria. Alginate-based PPHB is more suitable for encapsulating functional ingredients for colon-targeted delivery and modulating gut microbiota.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"140375"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Licorice endophytes activate glycyrrhizin synthesis metabolic flux through feedback of β-glucuronidase conversion activity.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-01-29 DOI: 10.1016/j.ijbiomac.2025.140484

Xin Zuo, Yao Xu, Guangxi Ren, Dan Jiang, Chunsheng Liu

{"title":"Licorice endophytes activate glycyrrhizin synthesis metabolic flux through feedback of β-glucuronidase conversion activity.","authors":"Xin Zuo, Yao Xu, Guangxi Ren, Dan Jiang, Chunsheng Liu","doi":"10.1016/j.ijbiomac.2025.140484","DOIUrl":"10.1016/j.ijbiomac.2025.140484","url":null,"abstract":"Terpenoids are widely distributed in plants and are often used as defense molecules in plant-microbe interactions. However, endophytic microorganisms usually establish a better symbiotic relationship with their hosts by secreting enzymes to avoid defense plant metabolites. This study evaluated the in vitro biotransformation activity of licorice endophytic fungi on glycyrrhizin and further explored the molecular regulation of their in vivo colonization on the licorice growth and metabolism. The results indicated that licorice endophytic fungi generally possessed the ability to bio-transform glycyrrhizin, with Z6 and Z15 exhibiting glycyrrhizin-induced β-glucuronidase activity. The Z6GH2 and Z15GH2 proteins were identified to hydrolyze glycyrrhizin in different ways by prokaryotic and eukaryotic experiments. In vivo re-infestation of licorice by Z6 and Z15 revealed significant promotion of glycyrrhizin biosynthesis and accumulation by regulating the expression levels of genes involved in glycolysis and glycyrrhizin biosynthesis pathway in licorice. These findings were further validated in J3, which has glycyrrhizin biotransformation properties. In summary, this study reveals the molecular mechanism by which endophytic fungi with glycyrrhizin β-glucuronidase activity promote glycyrrhizin biosynthesis and accumulation in licorice through feedback regulation of its metabolic flux. These finding highlight the importance of endophytic fungi in regulating the accumulation of active ingredients in medicinal plants.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"140484"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Freeze-thaw pretreatment improved the anti-digestibility and viscosity of corn starch/type-A gelatin complexes.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-02-03 DOI: 10.1016/j.ijbiomac.2025.140648

Yi Liu, Jihong Qu, Die Dong, Zhengzong Wu, Huiyan Ma, Lu Lu, Zheng Zhang, Chao Yuan, Meng Zhao, Bo Cui

{"title":"Freeze-thaw pretreatment improved the anti-digestibility and viscosity of corn starch/type-A gelatin complexes.","authors":"Yi Liu, Jihong Qu, Die Dong, Zhengzong Wu, Huiyan Ma, Lu Lu, Zheng Zhang, Chao Yuan, Meng Zhao, Bo Cui","doi":"10.1016/j.ijbiomac.2025.140648","DOIUrl":"10.1016/j.ijbiomac.2025.140648","url":null,"abstract":"Slowly digestible starches, known to confer health benefits, are often prepared via compounding with other substances. However, starch complexes often encounter problems such as low viscosity. This work aimed to develop a corn starch/type-A gelatin (CS/GA) complex that simultaneously exhibited rapidly digestible starch (RDS) reduction, and superior viscosity. The pH and drying temperature of the complexes were systematically optimized, and a novel freeze-thaw pretreatment (FTP) technique was innovatively introduced. This work investigated the effects of varying FTP cycles (ranging from 0 to 8) on the physicochemical properties of CS/GA complexes. Results showed that FTP significantly enhanced the viscosity of the complexes while effective RDS reduction. Notably, after six FTP cycles, the complexes attained optimal properties, characterized by the highest the complex index (CI), relative crystallinity (RC) and short-range molecular order, accompanied by the lowest RDS reduction of 46.24 %. The multivariate analysis revealed CI as the crucial parameter for altering the resistant starch (RS) content. Furthermore, FTP induced cracking on the surface of starch particles was observed. In conclusion, these results were of significance for developing CS-based food materials with RDS reduction, and high viscosity characteristics, such as noodles, corn porridge and sausage.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"140648"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced chitosan hybrid dye labels for dynamic monitoring of shrimp and milk freshness.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-02-03 DOI: 10.1016/j.ijbiomac.2025.140652

Arnat Ronte, Jongjit Chalitangkoon, Tanaporn Sintoppun, Nantawan Niemhom, Nuttaporn Manapradit, Pimpaporn Munpiriyakul, E Johan Foster, Pathavuth Monvisade

{"title":"Advanced chitosan hybrid dye labels for dynamic monitoring of shrimp and milk freshness.","authors":"Arnat Ronte, Jongjit Chalitangkoon, Tanaporn Sintoppun, Nantawan Niemhom, Nuttaporn Manapradit, Pimpaporn Munpiriyakul, E Johan Foster, Pathavuth Monvisade","doi":"10.1016/j.ijbiomac.2025.140652","DOIUrl":"10.1016/j.ijbiomac.2025.140652","url":null,"abstract":"This study presents the development of intelligent screen-printed labels for real-time food freshness monitoring. Using chitosan grafted with rosolic acid (RA) and immobilized on montmorillonite (MMT) through cationic exchange, a hybrid dye was synthesized and applied in screen-printing inks. The hybrid structure was characterized by XRD, TGA, and UV-vis, confirming improved thermal stability and maintained halochromic properties. SEM analysis showed consistent ink deposition on filter paper, while water contact angle (WCA) measurements demonstrated enhanced surface hydrophobicity due to the MMT. The labels exhibited clear pH-sensitive color transitions from yellow to purplish red (pH 2.0-12.0) and rapid ammonia sensitivity, with ΔE values exceeding 45.0 within 10 min. The labels also demonstrated excellent reversibility, storage stability, leaching resistance, and cytocompatibility. Practical tests on shrimp and milk confirmed the labels' ability to accurately monitor freshness through visible color changes. These findings highlight the potential of hybrid labels as effective, scalable freshness indicators for intelligent food packaging.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"140652"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A ternary deep eutectic solvent for efficient biomass fractionation and lignin stabilization. 一种用于高效生物质分馏和木质素稳定的三元深共熔溶剂。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-01-19 DOI: 10.1016/j.ijbiomac.2025.140070

Yao Zheng, Pengcheng Xue, Rong Guo, Jianyu Gong, Guangfu Qian, Changzhou Chen, Douyong Min, Yan Tong, Minsheng Lu

{"title":"A ternary deep eutectic solvent for efficient biomass fractionation and lignin stabilization.","authors":"Yao Zheng, Pengcheng Xue, Rong Guo, Jianyu Gong, Guangfu Qian, Changzhou Chen, Douyong Min, Yan Tong, Minsheng Lu","doi":"10.1016/j.ijbiomac.2025.140070","DOIUrl":"10.1016/j.ijbiomac.2025.140070","url":null,"abstract":"The efficient isolation and lignin stabilization are critical to the fractionation process of lignocellulosic biomass, enabling the subsequent valorization of both carbohydrates and lignin. In this study, a ternary deep eutectic solvent pretreatment system with outstanding reusability has been developed. Under optimal conditions (ChCl: MT: p-TsOH = 1:1:0.5, 120 °C, 60 min), the system efficiently removed 94.66 % of hemicellulose and 95.74 % of lignin while retaining 84.50 % of cellulose. Glucose was obtained from the cellulose-rich solid residue via enzymatic hydrolysis, achieving an 87.12 % yield. This DES system inhibits lignin condensation through a dual mechanism of α-etherification and intermolecular forces (π-π stacking and hydrophobic interaction). The recovered lignin exhibits a low molecular weight (922-1049 g/mol), high phenolic hydroxyl content (2.57-3.37 mmol/g), low polydispersity (1.54-1.61), and high purity (93.02 %). Combined with its superior antioxidant activity and UV shielding properties, this lignin represents a promising new resource with potential applications.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"140070"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural characterization of complex tannins from Euryale ferox fruit peels and their inhibitory mechanisms against tyrosinase activity and melanogenesis. 芡实果皮复合单宁的结构特征及其对酪氨酸酶活性和黑素生成的抑制机制。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-01-14 DOI: 10.1016/j.ijbiomac.2025.139909

Lang Wu, Wei Song, Yu Jiang, Ying Dai, Zeya Qin, Lulu Liu, Shudong Wei, Hui Chen

{"title":"Structural characterization of complex tannins from Euryale ferox fruit peels and their inhibitory mechanisms against tyrosinase activity and melanogenesis.","authors":"Lang Wu, Wei Song, Yu Jiang, Ying Dai, Zeya Qin, Lulu Liu, Shudong Wei, Hui Chen","doi":"10.1016/j.ijbiomac.2025.139909","DOIUrl":"10.1016/j.ijbiomac.2025.139909","url":null,"abstract":"Tyrosinase is a rate-limiting enzyme for melanogenesis and abnormal melanin production can be controlled by utilizing tyrosinase inhibitory substances. To develop potent and safe inhibitors of tyrosinase, complex tannins a narrowly distributed plant polyphenols were prepared from the fruit peel of Euryale ferox (EPTs) and then structurally characterized, as well as investigated for their inhibitory effects and the involved mechanisms against tyrosinase activity and melanogenesis. The structures of EPTs were established to consist of 63.49% hydrolyzable tannins and 36.51% flavan-3-ol units. EPTs inhibited both the monophenolase and diphenolase activities of tyrosinase efficiently. This outstanding inhibition was presumably ascribed to the strong copper-ion chelating ability of EPTs and the microenvironment modification and secondary structure rearrangement of tyrosinase caused by the formation of EPTs-tyrosinase complexes. Treatment of EPTs to B16F10 cells also decreased the intracellular tyrosinase activity, induced apoptosis and G2/M cell cycle arrest, suppressed melanoma cell proliferation and downregulated the mRNA expression of tyrosinase, TRP-1 and MITF, consequently leading to a distinct reduction in melanin content. Furthermore, EPTs exhibited powerful antioxidant properties, which maybe contributed to impeding the initial steps of melanin formation. This study offered theoretical guidance for the potential applications of EPTs in cosmetic, functional food and medical industries.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"298 ","pages":"139909"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimized enzymatic PLA hydrolysis by a recombinant fungal cutinase: A step towards a closed PLA cycle.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-01-29 DOI: 10.1016/j.ijbiomac.2025.140482

Carlos Murguiondo, Jorge Barriuso, Alicia Prieto

引用次数: 0

Influence of different pulping processes, cold caustic extraction, and bleaching as common post-treatments on properties of produced lignocellulose nanocrystals (LCNCs) from bagasse.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-04-01 Epub Date: 2025-02-24 DOI: 10.1016/j.ijbiomac.2025.141448

Saleh Ghahramani, Sahab Hedjazi, Soheila Izadyar, Steffen Fischer, Ali Abdulkhani

{"title":"Influence of different pulping processes, cold caustic extraction, and bleaching as common post-treatments on properties of produced lignocellulose nanocrystals (LCNCs) from bagasse.","authors":"Saleh Ghahramani, Sahab Hedjazi, Soheila Izadyar, Steffen Fischer, Ali Abdulkhani","doi":"10.1016/j.ijbiomac.2025.141448","DOIUrl":"10.1016/j.ijbiomac.2025.141448","url":null,"abstract":"The influence of different pulping processes-soda, monoethanolamine, and Formacell-along with cold caustic extraction (CCE) and a bleaching sequence (DEpD) as post-treatments on the properties of lignocellulosic nanocrystals (LCNCs) was evaluated. LCNCs were produced through acid hydrolysis from the pulps. SEM and AFM analyses confirmed the successful production of LCNCs with dimensions under 100 nm. FT-IR analysis indicated the presence of lignin in the nanocrystals. X-ray diffraction demonstrated that acid hydrolysis and CCE significantly impacted the crystallinity of the LCNCs; however, the bleaching effect was minimal. Thermal analysis revealed that LCNCs derived from post-treated pulps exhibited greater thermal stability than those from untreated pulps. LCNCs were utilized to create films using the solution-casting method. The produced films from various pulps and post-treatments displayed excellent and diverse mechanical and aesthetic properties. The results indicated that the pulping processes, post-treatments, and chemical composition of the pulps influenced the characteristics of both LCNCs and LCNC films. The findings suggest that CCE can be a cost-effective and eco-friendly alternative to bleaching in the production of LCNCs. Furthermore, an increase in lignin content within the pulps was found to reduce the efficiency of acid hydrolysis and crystallinity while increasing the dimensions of the LCNCs.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"141448"},"PeriodicalIF":7.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0