International Journal of Biological Macromolecules最新文献_第5页

Alginate-based dual-drug bridging hydrogels harnessing dynamic PtO coordination for programmed drug delivery and efficient cancer combination therapy. 基于海藻酸盐的双药桥接水凝胶利用动态PtO协调程序药物输送和有效的癌症联合治疗。

IF 8.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2026-10-14 DOI: 10.1016/j.ijbiomac.2026.154870

Shu Wei, Yanglin Lv, An Yan, Jun Yang, Muhan Chen, Zixuan Wang, Xinyi Chen, Mengping Qu, Xiaodan Xie, Hongcheng Sun, Jiayun Xu, Junqiu Liu, Shuangjiang Yu

{"title":"Alginate-based dual-drug bridging hydrogels harnessing dynamic PtO coordination for programmed drug delivery and efficient cancer combination therapy.","authors":"Shu Wei, Yanglin Lv, An Yan, Jun Yang, Muhan Chen, Zixuan Wang, Xinyi Chen, Mengping Qu, Xiaodan Xie, Hongcheng Sun, Jiayun Xu, Junqiu Liu, Shuangjiang Yu","doi":"10.1016/j.ijbiomac.2026.154870","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.154870","url":null,"abstract":"Although hydrogel-based drug delivery shows promise for localized cancer therapy, effective combination strategies remain needed. Herein, a dual-drug bridging hydrogel was engineered using cisplatin (CDDP) and hematoporphyrin (HP) as crosslinking agents to improve combination therapy for tumors. This hydrogel platform facilitates the codelivery of aCTLA-4 antibodies and exhibits potent antitumor efficacy in a melanoma model. PtO coordination bonds among CDDP, HP, and sodium alginate stabilize the scaffold and reduce the burst release of HP, thereby enhancing photodynamic therapy. Under 630 nm laser irradiation, HP produces cytotoxic reactive oxygen species, and the hydrogel matrix breaks down in response to environmental triggers, enabling sustained drug release and resulting in prolonged therapeutic effects. This process induces cell apoptosis and releases tumor antigens and damage-associated molecular patterns. In a subcutaneous B16-F10 melanoma model, aCTLA-4@HP-SC-Gel with laser irradiation achieved exceeding 97% tumor growth inhibition and prolonged 50-day survival, with no obvious systemic toxicity. It increased intratumoral CD8+ T cells by 11-fold and promoted M1 macrophage polarization. By integrating chemotherapy, photodynamic therapy, and immunotherapy, this dual-drug bridging hydrogel offers a hopeful strategy for localized treatment of superficial tumors.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"154870"},"PeriodicalIF":8.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct Ca²⁺-binding thermodynamics reveal a paralogue-specific structural response in the calmodulin-like domain of α-actinin-4. 不同的Ca2+结合热力学揭示了α-肌动蛋白4的钙调素样结构域的平行特异性结构响应。

IF 8.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2026-10-14 DOI: 10.1016/j.ijbiomac.2026.154866

Jošt Hočevar, Matic Kovačič, Janez Plavec, Kristina Djinović-Carugo, Miha Pavšič

{"title":"Distinct Ca2+-binding thermodynamics reveal a paralogue-specific structural response in the calmodulin-like domain of α-actinin-4.","authors":"Jošt Hočevar, Matic Kovačič, Janez Plavec, Kristina Djinović-Carugo, Miha Pavšič","doi":"10.1016/j.ijbiomac.2026.154866","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.154866","url":null,"abstract":"The actin cytoskeleton, a complex and dynamic network, is precisely organized into structurally and functionally diverse assemblies by actin-binding proteins. A major group of actin crosslinking proteins are α-actinins. The non-muscle forms, α-actinin-1 and -4, are ubiquitous proteins whose actin crosslinking activity is regulated by Ca2+ ions. The molecular mechanism of regulation is unknown, but it has been suggested to be driven by structural changes triggered by the binding of Ca2+ ions to their calmodulin-like domain (CaMD). While the structure and Ca2+-binding properties of human α-actinin-1 CaMD have already been investigated, no such data were available for the α-actinin-4 CaMD. To address this, we used structurally informed mutagenesis and isothermal titration calorimetry (ITC) to confirm a homologous single Ca2+-binding site in the N-terminal lobe of the α-actinin-4 CaMD. In stark contrast to the α-actinin-1 CaMD, where binding is endothermic, binding to the α-actinin-4 CaMD is exothermic and displays a 6-fold lower affinity towards Ca2+. These distinct thermodynamic signatures suggest a paralogue-specific conformational change. Indeed, protein NMR spectroscopy revealed a unique Ca2+-induced conformational change of the C-terminal lobe, providing new insights into the molecular mechanisms that modulate α-actinin-mediated actin crosslinking.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"154866"},"PeriodicalIF":8.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering acid-sensing ion channel 1a with disrupted desensitization: A computer-guided approach. 工程酸敏感离子通道1a与中断脱敏：计算机引导的方法。

IF 8.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2026-10-14 DOI: 10.1016/j.ijbiomac.2026.154826

Mahdi Hassankalhori, Mina Hanna, Ferran Sancho, Juan Torras, Stephan Kellenberger, Maria Fátima Lucas

{"title":"Engineering acid-sensing ion channel 1a with disrupted desensitization: A computer-guided approach.","authors":"Mahdi Hassankalhori, Mina Hanna, Ferran Sancho, Juan Torras, Stephan Kellenberger, Maria Fátima Lucas","doi":"10.1016/j.ijbiomac.2026.154826","DOIUrl":"10.1016/j.ijbiomac.2026.154826","url":null,"abstract":"Human Acid-Sensing Ion Channel 1a (hASIC1a) is a complex, multi-state membrane macromolecule whose rapid desensitization limits its application as a natural biosensor. To manipulate these structural dynamics, we designed and applied an integrative computational approach, combining protein residue network analysis and a machine learning-based functional site model, to identify functionally important positions governing hASIC1a desensitization. Focusing on structural communication regions, we pinpointed novel regulatory positions modulating the channel's conformational dynamics involving the desensitized state. Through the experimental characterization of a targeted library of 26 variants across nine predicted positions, we discovered three critical regulatory functional sites (Y426, L453, and Y456). Mutations at these sites yielded eight variants that successfully impaired or disrupted desensitization over a wide pH range, resulting in sustained current properties. This study demonstrates how our integrative computational strategy can be successfully applied to dynamically intricate membrane proteins, efficiently identifying mutational hotspots to engineer and fine-tune complex macromolecular functional properties.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"154826"},"PeriodicalIF":8.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic effect of modified konjac glucomannan and biological enzyme induced carbonate precipitation on the biocementation of soil fugitive dust. 改性魔芋葡甘露聚糖与生物酶诱导碳酸盐沉淀对土壤逸散性粉尘生物胶结的协同效应。

IF 8.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2026-10-13 DOI: 10.1016/j.ijbiomac.2026.154834

Xiaonan Wang, Kai Chen, Peng Chen, Chongyu Zhang, Yue Hu, Guihong Liu, Yong Zhang, Yongjie Shi, Chenyu Kong, Xiang Li

{"title":"Synergistic effect of modified konjac glucomannan and biological enzyme induced carbonate precipitation on the biocementation of soil fugitive dust.","authors":"Xiaonan Wang, Kai Chen, Peng Chen, Chongyu Zhang, Yue Hu, Guihong Liu, Yong Zhang, Yongjie Shi, Chenyu Kong, Xiang Li","doi":"10.1016/j.ijbiomac.2026.154834","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.154834","url":null,"abstract":"Soil fugitive dust poses a serious threat to human health, the plant-derived polysaccharide konjac glucomannan was modified to obtain konjac glucomannan-acrylic acid graft copolymer (KGMP), which was combined with enzyme induced carbonate precipitation (EICP) to control it. The performance of KGMP-EICP was evaluated. Microstructure characterization was performed on the treated soil fugitive dust samples, and molecular dynamics simulations were employed to investigate how KGMP regulates the nucleation of calcium carbonate, thereby elucidating the fugitive dust control principle of KGMP-EICP. Results indicate that the concentration of KGMP at 3 mg/mL maximizes the yield of calcium carbonate in EICP. KGMP improves the EICP's resistance to wind erosion, the hardness of the solidified layer, water retention, and resistance to rain erosion, while exhibiting a moderate degradation rate. In field experiments, KGMP-EICP exhibited a lower average daily TSP concentration than EICP after 30 days. Microscopic characterization revealed that KGMP resulted in a more uniform calcium distribution, regulated the preferential orientation of calcite crystals, and increased their crystallinity and grain size. In the molecular dynamics simulation, KGMP provided sites for the precipitation of calcium carbonate, which improved the probability of the combination of carbonate ions and calcium ions, and increased the average interaction energy between them by 521.27 Kcal/mol. The dust suppression mechanism of KGMP-EICP is that the soil fugitive dust forms a dense solidified layer of calcite under the regulation of KGMP. This study provides theoretical support and new strategies for the application of biomacromolecular functional materials in dust pollution control.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"154834"},"PeriodicalIF":8.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting cellulosic fibrils in papermaking: from ancient papermaking principles to room-temperature engineering of "plastic-like" paper via in-situ fibril-derived additives. 重新审视造纸中的纤维原纤维：从古代造纸原理到通过原位纤维衍生添加剂制造“类塑料”纸的室温工程。

IF 8.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2026-10-13 DOI: 10.1016/j.ijbiomac.2026.154859

Jianmin Peng, Xin Fu, Gavin Scott, Rob Barker, Graham Ormondroyd, Simon F Curling, Hui Mao, Jing Shen

{"title":"Revisiting cellulosic fibrils in papermaking: from ancient papermaking principles to room-temperature engineering of \"plastic-like\" paper via in-situ fibril-derived additives.","authors":"Jianmin Peng, Xin Fu, Gavin Scott, Rob Barker, Graham Ormondroyd, Simon F Curling, Hui Mao, Jing Shen","doi":"10.1016/j.ijbiomac.2026.154859","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.154859","url":null,"abstract":"Papermaking, one of ancient China's greatest innovations, shaped human civilization through the creation of true paper, widely attributed to Cai Lun during the Eastern Han Dynasty. A defining feature of this invention was the formation of fibrillated microstructures during fibre processing, which promoted fibre bonding and sheet formation. Inspired by this principle, the present work revisits the structural role of cellulosic fibrils and explores their potential as functional building blocks for materials innovation. By enhancing fibrillation through controlled pulp refining, a straightforward room-temperature strategy was developed to produce \"plastic-like\" paper, herein referring to cellulosic paper combining high wet strength, flexibility, and liquid barrier performance while retaining its fibrous structure. During treatment with a non-derivatizing zinc chloride-based solvent system, accessible fibrillated structures are proposed to undergo partial dissolution and subsequently regenerate within the fibre network, forming in-situ fibril-derived additives. The resulting fibril-derived material acts as an in-situ binding phase within the paper structure, bridging adjacent fibres and filling interfibre voids, thereby consolidating the network while preserving the overall fibrous architecture. As a result, the treated paper exhibits plastic-like high wet strength, improved liquid barrier performance, and antibacterial activity associated with residual zinc species. Because fibrillated microstructures are widely present in refined pulps, the approach also shows potential for application to different papermaking fibres. Rooted in the principles of papermaking wet-end chemistry and chemical additives, this work reinterprets cellulosic fibrils as in-situ functional additives and highlights new opportunities for designing multifunctional sustainable materials.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"154859"},"PeriodicalIF":8.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physicochemical properties, in vitro digestive behavior, and fecal fermentation characteristics of a polysaccharide fraction from Triadica rotundifolia. 圆叶三里草多糖组分的理化性质、体外消化行为和粪便发酵特性。

IF 8.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2026-10-13 DOI: 10.1016/j.ijbiomac.2026.154852

Peiyao Wang, Siming Zhu, Xinyu Wang, Yulan Gan, Haiyan Zhao

{"title":"Physicochemical properties, in vitro digestive behavior, and fecal fermentation characteristics of a polysaccharide fraction from Triadica rotundifolia.","authors":"Peiyao Wang, Siming Zhu, Xinyu Wang, Yulan Gan, Haiyan Zhao","doi":"10.1016/j.ijbiomac.2026.154852","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.154852","url":null,"abstract":"In this study, a polysaccharide fraction from Triadica rotundifolia (formerly Sapium rotundifolium Hemsl.), designated RSP, was obtained by hot-water extraction, ethanol precipitation, Sevag deproteinization, and sequential chromatographic purification. Its physicochemical characteristics, simulated digestive behavior, and effects on human fecal microbiota were systematically evaluated. RSP was obtained at a yield of 1.21%, and high-performance gel permeation chromatography (HPGPC) showed a dominant chromatographic peak with a weight-average molecular weight (Mw) of 322,357 Da. RSP exhibited a distinct monosaccharide composition, with arabinose, glucuronic acid, galactose, and glucose as the major monosaccharides. Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and atomic force microscopy (AFM) further revealed typical polysaccharide functional groups and an aggregated, irregular morphological organization. During simulated gastrointestinal digestion, reducing-sugar equivalents changed only slightly during the salivary and gastric phases but increased markedly during the intestinal phase. The presence of RSP during in vitro fecal fermentation resulted in notable alterations in culture turbidity, progressive acidification, relative SCFA profiles, and microbial community structure. Furthermore, 16S ribosomal RNA gene sequencing revealed distinct fecal microbial community profiles among the RSP, Blank, and INU groups. In the LEfSe multigroup comparison, Bifidobacterium was identified as one of the taxa characterizing the RSP group. Collectively, these findings provide an integrated characterization of the physicochemical properties, in vitro digestive behavior, and fecal fermentation characteristics of RSP.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"154852"},"PeriodicalIF":8.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanism of the multi-scale structure of starch-based materials in determining the compaction behavior of pharmaceutical powders. 淀粉基材料的多尺度结构对药物粉末压实性能的影响机制。

IF 8.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2026-10-13 DOI: 10.1016/j.ijbiomac.2026.154858

Yuan Lin, Xiao Lin, Lan Shen, Lijie Zhao

{"title":"Mechanism of the multi-scale structure of starch-based materials in determining the compaction behavior of pharmaceutical powders.","authors":"Yuan Lin, Xiao Lin, Lan Shen, Lijie Zhao","doi":"10.1016/j.ijbiomac.2026.154858","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2026.154858","url":null,"abstract":"This study aimed to investigate the multiscale structural evolution of starch under mechanical stress and its impact on the mechanical behavior of tablets. The study systematically characterized the multiscale structure, compression behavior, and tablet quality of seven types of starches with different initial structures (native starch, partially hydrolyzed starch, and deeply hydrolyzed starch) before and after dry granulation. The results demonstrate that dry granulation results in a reduction in the short-range and long-range ordered structures of starch (crystallinity decreased by 25.58-61.60%). This stress-induced structural disorder is correlated with increased plastic deformation in native starch and the fragmentation of hydrolyzed starch particles. The enhanced tensile strength (145.95%-228.57%) of partially hydrolyzed starch tablets may result from the increased specific surface area generated by particle fragmentation. In contrast, amorphous maltodextrin after granulation exhibits an enhanced elastic response due to mechanical densification and work hardening, with loss of tabletability. The correlation analysis indicates that the tensile strength of tablets is positively correlated with plastic deformation parameters and roughness, while it is negatively correlated with elastic parameters, short-range order, and crystallinity. These results indicate that the effect of dry granulation on tablet quality depends on the initial structural characteristics. While granulation improves the performance of starch-based tablets with high elastic response by disrupting their ordered structure, it may impair the performance of starch-based tablets with strong plastic deformation capacity due to work hardening. This structure-dependent regulatory relationship provides a theoretical basis for the design of starch-based excipients in solid dosage forms.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"154858"},"PeriodicalIF":8.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient biocatalytic synthesis of docosahexaenoic acid-enriched phosphatidylethanolamine (DHA-PE) by an engineered Streptomyces sp. Phospholipase D (PLD) with expanded active pocket. 扩展活性袋型链霉菌磷脂酶D高效生物催化合成富含二十二碳六烯酸的磷脂酰乙醇胺（DHA-PE）。

IF 8.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2026-10-13 DOI: 10.1016/j.ijbiomac.2026.154844

Chenxi He, Xi Chen, Rujing Diao, Xinyuan Zhang, Jianan Sun

{"title":"Efficient biocatalytic synthesis of docosahexaenoic acid-enriched phosphatidylethanolamine (DHA-PE) by an engineered Streptomyces sp. Phospholipase D (PLD) with expanded active pocket.","authors":"Chenxi He, Xi Chen, Rujing Diao, Xinyuan Zhang, Jianan Sun","doi":"10.1016/j.ijbiomac.2026.154844","DOIUrl":"10.1016/j.ijbiomac.2026.154844","url":null,"abstract":"Docosahexaenoic acid-enriched phosphatidylethanolamine (DHA-PE) represents a premium functional lipid with exceptional oxidative stability and bioavailability. However, the enzymatic synthesis of DHA-PE via Phospholipase D (PLD) is severely hindered by the extreme structural bulkiness of the polyunsaturated DHA acyl chain, resulting in low transphosphatidylation efficiency. To overcome this critical steric barrier, we employed a computationally guided semi-rational design strategy focused on remodeling the substrate-binding pocket of Streptomyces sp. PLD Sp-256. Among the 30 designed variants, the optimal mutant A409C was identified, delivering a remarkable 5.1-fold enhancement in apparent transphosphatidylation activity alongside a dramatically improved catalytic efficiency (kcat/Km). Molecular dynamics (MD) simulations unveiled the underlying structural basis: the A409C substitution effectively expands the active pocket volume and optimizes the substrate-binding free energy, thereby relieving the steric hindrance against the bulky DHA-phosphatidylcholine (DHA-PC). Through systematic process optimization (substrate molar ratio of 10:1, 40 μg enzyme loading, 40 °C, and a 1:1 v/v organic/aqueous biphasic system), the A409C biocatalyst achieved an unprecedented 88.6% conversion yield-the highest recorded for PLD-mediated DHA-PE synthesis to date. This study not only elucidates the structure-function relationship of the PLD pocket architecture but also establishes a robust and highly efficient biocatalytic platform for the industrial production of high-value polyunsaturated phospholipids.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"154844"},"PeriodicalIF":8.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "3D printed bioengineered scaffold containing chitosan, alginate, and Barijeh-loaded niosomes enabled efficient antibiofilm activity and wound healing" [Int. J. Biol. Macromol. (June 2025) Volume 311, Part 4, Article: 143743, 1-16]. “含有壳聚糖、海藻酸盐和barijeh负载的纳米体的3D打印生物工程支架能够实现有效的抗生物膜活性和伤口愈合”的更正[j]。生物。絮凝。（2025年6月）311卷，第4部分，条款：143743,1 -16]。

IF 8.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2026-10-13 DOI: 10.1016/j.ijbiomac.2026.154596

Ali Bidaki, Niloufar Rezaei, Sara Kazemi, Saba Naeimaei Ali, Seyedehrozhin Ziaei, Alaa Moeinzadeh, Fatemeh Hosseini, Hassan Noorbazargan, Ahmad Reza Farmani, Qun Ren

引用次数: 0

Ultrasound-induced structural reorganization enhances gelation and stability of flaxseed gum emulsion gels. 超声诱导的结构重组增强了亚麻籽胶乳液凝胶的凝胶化和稳定性。

IF 8.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2026-10-13 DOI: 10.1016/j.ijbiomac.2026.154839

Janice Adaeze Nwankwo, Xiusheng Guo, Wenxue Liu, Wang Wenjuan, Imad Khan, Victor Olusola Opatola, Xiaoqiang Zou

{"title":"Ultrasound-induced structural reorganization enhances gelation and stability of flaxseed gum emulsion gels.","authors":"Janice Adaeze Nwankwo, Xiusheng Guo, Wenxue Liu, Wang Wenjuan, Imad Khan, Victor Olusola Opatola, Xiaoqiang Zou","doi":"10.1016/j.ijbiomac.2026.154839","DOIUrl":"10.1016/j.ijbiomac.2026.154839","url":null,"abstract":"Flaxseed gum (FG) possesses the potential to stabilize emulsions without ions or additional gelling agents, but its limited intrinsic interfacial activity typically requires high concentrations to achieve adequate stability, resulting in coarse droplets, weak gel networks, and reliance on co-stabilizers. Whether the properties of FG can be sufficiently improved to serve as a stabilizer in emulsion gels remains unclear. To address this, the effects of ultrasound modification on FG emulsion gels were investigated under specific power-time treatment sequences to study the mechanisms of FG as a sole stabilizer. Ultrasound markedly improved functional properties: EAI increased from 15.07 to 26.23 m2/g at FG 0.8% (250 W/7 min) and from 14.88 to 30.23 m2/g at FG 1.2% (350 W/15 min). ESI rose from 144.97 to 463.44 min (FG 0.8%, 250 W/15 min) and 167.97 to 693.37 min (FG 1.2%, 350 W/15 min). WHC remained high (~95-99.7%), with maximal retention at FG 1.2%, 250 W/25 min. Particle size distributions indicated preserved macroaggregate structure, while FTIR suggests changes in molecular reorganization and possible enhancement in FG-oil interactions. LF-NMR showed reduced water mobility and stronger water-matrix interactions while XRD exhibited an amorphous gel nature indicating partial recovery of short-range order at higher power/time. Thermo-rheology revealed thermal reinforcement reaching the highest G' at the maximum temperature tested (85 °C) under 250 W/15 min. CLSM revealed refined droplet networks at moderate conditions, with partial recoalescence under prolonged high-power treatment. These results support the potential for ultrasound modified FG to function as a sole stabilizer in food-based gels.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"154839"},"PeriodicalIF":8.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0