International Journal of Biological Macromolecules最新文献

{"title":"Corrigendum to \"Quaternary ammonium carboxymethyl chitosan composite hydrogel with efficient antibacterial and antioxidant properties for promoting wound healing\" [Int. J. Biol. Macromol. 268 (2024) 131871].","authors":"Yahao Ma, Xujie Zhou, Zhendong Mo, Qing Zhou, Bingyu Hui, Zhuangzhuang Cai, Xiaoying Wang, Hang Li, Shunqing Tang","doi":"10.1016/j.ijbiomac.2025.144568","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.144568","url":null,"abstract":"","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"144568"},"PeriodicalIF":7.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the water resistance and functional properties of chitosan-based films using a hydrophobic deep eutectic solvent.","authors":"Zixing Zhang, Yuxin Xu, Yun Hu","doi":"10.1016/j.ijbiomac.2025.144776","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.144776","url":null,"abstract":"<p><p>To enhance the mechanical properties and water resistance of chitosan (CS) films while imparting additional functionalities, this study incorporated a hydrophobic deep eutectic solvent (DES) composed of menthol and pyruvic acid into the CS matrix. At an optimal DES content of 15 %, compared to pure CS films, the elongation at break increased by 77 %, while swelling degree and solubility decreased by 94.44 % and 60.71 %, respectively. The lowest water vapor permeability (11.55 × 10^-11 g·m^-1·s^-1·Pa^-1) demonstrated enhanced moisture barrier properties. These improvements were attributed to the synergistic effects of hydrogen bonding and ionic crosslinking, reinforcing the network structure and restricting water penetration while maintaining molecular mobility. The films also exhibited excellent ultraviolet-shielding (ultraviolet C transmittance of 3 %) with high transparency, making them suitable for light-sensitive packaging. Additionally, they achieved complete biodegradation in soil within 10 weeks, highlighting their potential as sustainable alternatives to petroleum-based plastics. This study presents a novel approach to enhancing bio-based packaging materials through hydrophobic DES, expanding their applications in sustainable food and pharmaceutical packaging.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"144776"},"PeriodicalIF":7.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of zirconium/chitosan functionalized magnetic carbon nanotubes for enhanced adsorption of alizarin red.","authors":"Jing Jin, Hanyu Zhang, Aaron Albert Aryee, Yuanyuan Wang, Rashda Safdar, Weimin Shi, Lingbo Qu, Runping Han","doi":"10.1016/j.ijbiomac.2025.144779","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.144779","url":null,"abstract":"<p><p>In this study, a composite adsorbent (Zr-CMCNTs) based on modification of magnetic carbon nanotubes (MCNTs) with chitosan (CS) and zirconium oxychloride octahydrate (ZrOCl₂·8H₂O) was synthesized and showed excellent adsorption ability for alizarin red (AR) in aqueous solution. The maximum adsorption capacity of Zr-CMCNTs for AR could reach 889 mg·g^-1 at 313 K (pH = 3.4). And the performance was not significantly affected by the presence of common ions, showing good salt tolerance. The adsorption equilibrium process was consistent with Langmuir, Freundlich, Koble-Corrigan, and Temkin models, suggesting that both monolayer and multilayer adsorption were involved. The adsorption kinetic process was well described by the pseudo-second-order, Elovich and Double constant kinetic models. The thermodynamic parameters calculated confirm the adsorption process to be spontaneous, endothermic and entropy-increasing. Analyses of the underlying mechanism shows that the adsorption process was mainly due to complexation, hydrogen bonding, π-π stacking and electrostatic attraction. The magnetic property enables Zr-CMCNTs to be recovered easily following adsorption. After three desorption and regeneration cycles, the removal rate of AR still reached 60 %, indicating good reusability. Overall, Zr-CMCNTs composite adsorbent shows great potential in dye wastewater treatment.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"144779"},"PeriodicalIF":7.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rational design of S-adenosylmethionine decarboxylase SpeD and spermidine synthase SpeE for green synthesis of spermidine","authors":"Ziyue Zhao ,&nbsp;Dian Zou ,&nbsp;AnYing Ji,&nbsp;Yingchao Wu,&nbsp;Ailing Guo,&nbsp;Xuetuan Wei","doi":"10.1016/j.ijbiomac.2025.144680","DOIUrl":"10.1016/j.ijbiomac.2025.144680","url":null,"abstract":"<div><div>Spermidine, a natural polyamine, possesses multiple biological activities and holds excellent application value. However, the low-activity enzymes in spermidine synthesis pathway limits spermidine production, including S-adenosylmethionine decarboxylase (SpeD) and spermidine synthase (SpeE). In <em>Bacillus amyloliquefaciens</em> PM1 with xylose as substrate, this study performed the alanine scanning mutagenesis to screen the beneficial mutants of SpeD and SpeE by rational design. Therein, the spermidine titers of mutants PM1/<em>speD</em>^I39A/D22A and PM1/<em>speE</em>^I108A/T54A were improved by 53 % and 44 % compared to the control strain, respectively, and the enzyme activities of the SpeD^I39A/D22A and SpeE^I108A/T54A increased by 58 % and 44 % accordingly. The mechanism of the enhanced enzymatic activity was further explained by molecular dynamics simulations. Moreover, the optimal engineering strain PM1::D/E was constructed by combination of <em>speD</em>^I39A/D22A and <em>speE</em>^I108A/T54A to enhance spermidine pathway. Through fed-batch fermentation, the maximum spermidine titer reached 683.14 mg/L, representing a 16.38-fold increase in spermidine production compared with the unmodified strain PM1. This study provides a novel strategy for green synthesis of spermidine from xylose, which will promote the clean and efficient production of spermidine.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"316 ","pages":"Article 144680"},"PeriodicalIF":7.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tenuazonic acid delays postharvest kiwifruit softening by inhibiting starch and cell wall degradation, and maintaining ROS homeostasis during ambient storage.","authors":"Huiling Yan, Ludong Huang, Qingxia Liao, Mengying Xia, Tian Yao, Haiou Liu, Hongxu Chen, Wanjie Li","doi":"10.1016/j.ijbiomac.2025.144780","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.144780","url":null,"abstract":"<p><p>Postharvest rapid softening compromises kiwifruit quality and marketability, necessitating effective preservative strategies. This study investigated the efficacy of tenuazonic acid (TeA) in delaying kiwifruit softening during ambient storage. TeA treatment significantly postponed kiwifruit softening by inhibiting starch and cell wall degradation. Specifically, TeA maintained the higher levels of starch, protopectin (PP), hemicellulose and cellulose, while reducing the water soluble pectin (WSP) content. These effects were attributed to the modulation of key enzyme activities, including β-amylase (BAM), pectate lyase (PL) and cellulase (Cx), as well as the regulation of gene expression (e.g., AcPME1, AcPME2, AcPL4, AcPL5, AcGal1, AcXTH14, and AcXTH17). Additionally, TeA enhanced the activity of superoxide dismutase (SOD) and peroxidase (POD), ascorbic acid (AsA) content, as well as the scavenging capacities of 2, 2-Diphenyl-1-picrylhydrazyl (DPPH) and 2, 2'-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), thereby reducing the accumulation of hydrogen peroxide (H₂O₂) and malondialdehyde (MDA). Collectively, our findings demonstrated TeA maintained kiwifruit quality and suppressed softening via inhibiting starch and cell wall degradation, and boosting the antioxidant system. This treatment shows promise for extending shelf life and delaying softening of kiwifruit.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"144780"},"PeriodicalIF":7.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards a universal size distribution in a polymer network. Implications for drug delivery and plasmonic nanoparticle transport phenomena in polysaccharide and synthetic hydrogels.","authors":"Stefano A Mezzasalma, Michela Abrami, Gabriele Grassi, Mario Grassi","doi":"10.1016/j.ijbiomac.2025.144741","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.144741","url":null,"abstract":"<p><p>Polymeric hydrogels are paramount to outstanding applications in biology, medicine, pharmacy. Their similarity to living tissues is leveraged in clinical branches (oncology, cardiology, immunology, neurology, wound healing) for delivering a large range of drugs (encompassing DNA, RNA, protein molecules) and realizing in-vivo models of stimuli-responsive or controlled drug release. Rubber elasticity theory and the swollen network hypothesis are key for properly designing the geometric and mechanical features of hydrogels and polymer networks. The assumption of a Gaussian distribution of end-to-end lengths in a polymer molecule, however, can break down in several cases. Here, strongly supported by Low field NMR and rheology experiments, we propound the generalized Weibull law of extreme value statistics (EVS) to have universal validity in hydrogel materials. Mesh size values that account for an intrinsic statistical dependence between monomeric positions (or stiffness) show much better agreement with measurements conducted on physically crosslinked samples (agar, alginate and scleroglucan), including sputum specimens (rich in mucins) from patients affected by chronic respiratory conditions (cystic fibrosis) and on chemically crosslinked samples (poly-vinylpyrrolidone, PVP; poly-(ethylene-glycol/propylene-glycol), PEG/PPG). Across all ten gels, the Gaussian distribution yields the smallest average mesh size, ranging roughly from 7 nm for the densest alginate 2 % (9 gl^-1) hydrogel to about 80 nm for one of the sputum. Working with the pierced Gaussian inflates the mesh size to ≈1.5 × the Gaussian value, with increases from a modest +4 % in alginate 1 % up to nearly +100 % in the open PVP network (48 → 98 nm). The generalized Weibull distribution usually falls between the two Gaussians, yet in agar 1 % and scleroglucan 2 % it overtakes the pierced Gaussian (e.g. 20.2 > 15.8 nm for agar 1 %), reflecting a strong heavy-tailed distribution. The predicted mesh order therefore is Gaussian < generalized Weibull ≈ pierced Gaussian, with the precise ranking ruled by the width and skewness of each network statistics. Overall, our findings - being straightforward to apply - will profoundly impact on the description, conception and control of polymer networks, which often demand advanced instrumental techniques for compensating the lack of adequate predictive models. Among other relevant implications, aside from drug delivery, we highlight the characterization of the photothermal (or thermoplasmonic) response of hydrogel matrices hosting metal nanoparticles (e.g. with applications in hyperthermia cancer treatment and enhanced chemical processes). On the theoretical side, we emphasize the study of transport and thermomechanical properties of polymeric networks.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"144741"},"PeriodicalIF":7.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of the soybean ABF gene family and the key regulatory function of GmABF1 in salt stress response.","authors":"Bin-Shuo Zhang, Ming-Yang Li, Zhen Song, Jing-Pei Han, Zi-Qian Cheng, Xiang-Jin Chen, De-Zhi Han, Zhen-Bang Hu, Chun-Yan Liu, Ming-Liang Yang, Li-Juan Qiu, Xiao-Xia Wu, Ying Zhao","doi":"10.1016/j.ijbiomac.2025.144763","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.144763","url":null,"abstract":"<p><p>The abscisic acid (ABA) signaling pathway depends largely on ABRE-binding factors (ABFs), a distinct subfamily of plant bZIP transcription factors. Here, we carried out a genome-wide analysis of the ABF gene family in soybean (Glycine max (L.) Merr.) and investigated the function and regulatory mechanisms of GmABF1 in the plant's response to salt stress. A total of 20 GmABF genes were identified in the soybean genome, distributed across various chromosomes. The gene expression profiles of GmABF genes across diverse tissues and developmental stages in soybean indicate in regulating abiotic stress responses and plant hormone signaling. Among these genes, GmABF1 emerged as a key regulator of salt-stress tolerance. Functional assays showed that GmABF1 overexpression limited Na⁺ accumulation, reduced membrane damage, lowered reactive oxygen species (ROS) levels, and up-regulated ROS-scavenging enzymes, collectively alleviating oxidative stress and enhancing the plant's resilience to salinity. Additionally, three polymorphic sites in the promoter region of GmABF1 were identified, and their variation was closely associated with salt tolerance in soybean. These findings highlight the regulatory role of GmABF1 in salt stress responses and its potential for improving soybean stress tolerance.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"144763"},"PeriodicalIF":7.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrodia elata polysaccharide alleviates depression via gut microbiota modulation and Keap1-Nrf2/BDNF-TrkB pathway activation.","authors":"Min Wen, Mengmeng Liu, Yaoyuan Zhang, Boyang Qiao, Tongjie Luo, Gang Liu, Dan Li, Benhong Zhou","doi":"10.1016/j.ijbiomac.2025.144630","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.144630","url":null,"abstract":"<p><p>Oxidative stress plays a key role in the onset and development of depression, involving dysregulation of intestinal flora and abnormal cell signaling pathways. Gastrodia elata polysaccharide (GEP) presents great potential in neuroprotection and antidepressant effects. However, the specific mechanism underlying its neuroprotective effect remains unclear. This study elucidates how GEP alleviates depression in mice induced by chronic unpredictable mild stress (CUMS) and lipopolysaccharide (LPS). This study investigated the effects of GEP on intestinal flora composition and cell signaling pathways. Additionally, the study investigated its effects in an vitro LPS-induced PC12 cell model. Results indicated that GEP pretreatment effectively mitigated CUMS- and LPS-induced depressive behavior in mice. 16S rRNA sequencing results showed that GEP significantly altered gut microbiota composition in the CUMS model, reduced the Firmicutes/Bacteroidota ratio and increased microbial diversity. Western blotting and qRT-PCR revealed the role of GEP in regulating the Keap1-Nrf2/BDNF-TrkB signaling pathway in vivo and in vitro. Our findings provide insights into the potential mechanisms underlying the neuroprotective effects of GEP while establishing a solid foundation for future utilization of GEP.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"144630"},"PeriodicalIF":7.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan/zinc oxide (ZnO) nanocomposites: A critical review of emerging multifunctional applications in food preservation and biomedical systems","authors":"Bekinew Kitaw Dejene ,&nbsp;Mulat Alubel Abtew","doi":"10.1016/j.ijbiomac.2025.144773","DOIUrl":"10.1016/j.ijbiomac.2025.144773","url":null,"abstract":"<div><div>The increasing uses of petroleum-based materials for food packaging and medical applications raised significant environmental concerns. Researchers and industry stakeholders are actively exploring sustainable alternatives to replace those materials. Chitosan/zinc oxide (ZnO) bio-nanocomposites have emerged as promising alternatives to replace conventional plastics. Chitosan, a biodegradable biopolymer, exhibits exceptional film-forming properties, biocompatibility, and antimicrobial activity for sustainable application. On contrary, it has also certain drawbacks that limit its industrial applications including poor mechanical properties and high sensitivity to humidity. The integration of ZnO nanoparticles addresses these limitations by enhancing their mechanical strength, UV-blocking ability, stability, and functional properties with superior antimicrobial and antioxidant capabilities. This study critically examines past and current research, innovations, and development in chitosan/ZnO nanocomposites, with a focus on their sources, latest synthesis methods, properties, limitations and potentials applications in the food preservation and biomedical fields. Findings indicate that these nanocomposites can not only extend the shelf life of food products and are used for effective wound treatment, drug delivery, and tissue engineering but also reduces environmental impact. By highlighting recent advancements and future research directions, this review aims to promote the development of sustainable and eco-friendly solutions to address global challenges in food waste and healthcare.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"316 ","pages":"Article 144773"},"PeriodicalIF":7.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bi₅O₇I supported chitosan nanocomposite a robust, highly efficient, and sustainable catalyst for methyl orange pand 4-nitrophenol reduction.","authors":"Abdelmalik Brik, Mustapha El Kadiri, Taha El Assimi, Hicham Ben Youcef, Said Laassiri, Geraldine Gouhier, Abdellatif El Meziane, Abdelkrim El Kadib, Mohammed Lahcini","doi":"10.1016/j.ijbiomac.2025.144462","DOIUrl":"https://doi.org/10.1016/j.ijbiomac.2025.144462","url":null,"abstract":"<p><p>Chitosan (CS) has garnered significant attention as catalyst support due to its abundance, eco-friendliness, and renewable nature, making it a highly sustainable option in catalytic applications. We report herein a new simple and eco-friendly strategy to stabilize Bi₅O₇I nanosheets within CS-hydrogel and their immobilization in catalytic applications. The Bi₅O₇I nanosheets were firstly prepared through a solvothermal process and then stabilized within CS-hydrogel beads through a simple co-precipitation in alkaline media. The prepared Bi₅O₇I nanosheets and Bi₅O₇I@CSb composite were fully characterized by X-ray diffraction, XPS, SEM, EDS, TGA, FTIR, Raman, and Zeta-potential. Photodegradation experiments of methyl orange (MO) over Bi₅O₇I@CSb in aqueous media exhibit a high performance with a removal efficiency of up to 97 % within 120 min. Likewise, the Bi₅O₇I@CSb composite demonstrated a high reduction efficiency toward 4-nitrophenol (4-NP) reduction up total conversion within only 3 min using NaBH₄ as a reducing agent. More importantly, the Bi₅O₇I@CSb composite could easily be recovered from the reaction mixture by simple filtration with no significant loss of their activity and stability even after 7 and 10 successive uses for both MO and 4-NP, respectively. Thus, this contribution may offer a great opportunity for the use of CS bismuth-based materials in catalytic and photocatalytic wastewater treatment.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"144462"},"PeriodicalIF":7.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}