Osteoinductive gelatin-based porous nanocomposite hydrogel for enhanced hemorrhagic bone defect repair

IF 7.7 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

International Journal of Biological Macromolecules Pub Date : 2025-05-26 DOI:10.1016/j.ijbiomac.2025.144658

Dong Chen , Qinqin Yang , Fuzhou Tang , Xinping Wang , Honghong Zhang , Xiaomin Sun , Xiang Wang , Lijing Teng

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引用次数: 0

Abstract

Bone defects with uncontrolled hemorrhage significantly threaten patient survival, and traditional hemostatic agents are insufficient to synergistically treat noncompressible bone bleeding and enhance healing. Thus, developing a multifunctional material with excellent hemostatic and osteogenic performance is highly desirable. Herein, porous methacrylate-modified gelatin (GelMA)/Laponite (LAP) nanocomposite hydrogel (GLNH) via freeze-induced physicochemical cross-linking are readily constructed to treat bone defects with intractable bleeding. Porous GLNH exhibits a remarkable absorption capacity of up to 20 times, along with excellent physiological stability, adjustable pore size, and outstanding shape recovery capacity. In addition, porous GLNH demonstrates excellent biocompatibility and enhances osteogenesis by up-regulating the expression of osteo-specific genes. In a rat skull defect, porous GLNH exhibits favorable hemostatic effect, low inflammation, and improved bone repair. Overall, the multifunctional porous GLNH holds great potential for treating bone defects with intractable bleeding.

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基于骨诱导明胶的多孔纳米复合水凝胶增强出血性骨缺损修复

骨缺损伴出血失控严重威胁患者生存，传统止血药物不足以协同治疗不可压缩性骨出血并促进愈合。因此，开发一种具有优异止血和成骨性能的多功能材料是非常可取的。本文通过冷冻诱导的物理化学交联制备多孔甲基丙烯酸酯修饰明胶(GelMA)/拉脱石（LAP）纳米复合水凝胶（GLNH），用于治疗顽固性骨缺损出血。多孔GLNH具有优异的生理稳定性、可调节的孔径和出色的形状恢复能力，吸收能力可达20倍。此外，多孔GLNH表现出良好的生物相容性，并通过上调骨特异性基因的表达来促进成骨。在大鼠颅骨缺损中，多孔GLNH表现出良好的止血作用、低炎症和改善骨修复。总之，多功能多孔GLNH在治疗顽固性骨缺损出血方面具有很大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Biological Macromolecules 生物-生化与分子生物学

CiteScore

13.70

自引率

9.80%

发文量

2728

审稿时长

64 days

期刊介绍： The International Journal of Biological Macromolecules is a well-established international journal dedicated to research on the chemical and biological aspects of natural macromolecules. Focusing on proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids, the journal presents the latest findings in molecular structure, properties, biological activities, interactions, modifications, and functional properties. Papers must offer new and novel insights, encompassing related model systems, structural conformational studies, theoretical developments, and analytical techniques. Each paper is required to primarily focus on at least one named biological macromolecule, reflected in the title, abstract, and text.