Aging Medicine最新文献

{"title":"The Role of Extracellular Vesicles MicroRNAs in Sarcopenia: From Aging to Multi-Morbidity.","authors":"Bingyu Huang, Zhao Peng, Lin Kang","doi":"10.1002/agm2.70078","DOIUrl":"10.1002/agm2.70078","url":null,"abstract":"<p><p>Sarcopenia, defined as progressive loss of skeletal muscle mass and function, occurs during aging and has also been recognized for its detrimental effects in various disease states. Its prevention and management represent a critical aspect of geriatric care and multi-morbidity management. As a systemic disorder, extracellular vesicle-transported miRNAs mediate both intrinsic muscle pathology and multifaceted organ crosstalk. This review comprehensively summarizes and discusses the roles of EVs-miRNAs in sarcopenia under physiological aging and pathological conditions, and their emerging potential as diagnostic biomarkers and engineered therapeutic targets.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"185-195"},"PeriodicalIF":3.1,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13163945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147933987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"129-136"},"PeriodicalIF":2.5,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148089381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Model Development and Validation for Low Appendicular Skeletal Muscle Mass in Chinese Older Adults.","authors":"Minmin Chen, Xiaoqing Wu, Yanping Du, Wenjing Tang, Weijia Yu, Huilin Li, Qun Cheng","doi":"10.1002/agm2.70079","DOIUrl":"10.1002/agm2.70079","url":null,"abstract":"<p><strong>Objectives: </strong>Low skeletal muscle mass is associated with adverse clinical outcomes. Due to constraints related to cost and equipment availability, direct measurement of skeletal muscle mass is often not feasible in routine practice. This study aimed to develop and validate a practical predictive model for identifying low appendicular skeletal muscle mass (ASMM) in older adults.</p><p><strong>Methods: </strong>Body composition was assessed using DXA in the development group and BIA in the validation group. Standard questionnaires and anthropometric measurements were completed by trained testers. A predictive model was developed through multivariable binary logistic regression analysis and subsequently underwent external validation using an independent cohort to evaluate its generalizability.</p><p><strong>Results: </strong>A total of 393 elderly adults, aged 60-86 years (204 males, 189 females) participated in the study. The prevalence of Low ASMI was 74.0% in males and 58.2% in females. A predictive model for low ASMI was developed as Y = 75-BMI-CC (+10 if male). ROC analysis showed an AUC of 0.808 in the model development group, with sensitivity and specificity of 88.7% and 43.4% in males, and 83.6% and 44.3% in females, respectively. The model also demonstrated high accuracy in predicting low ASMI in the validation group. Using the prediction model, participants were categorized into three risk groups: high risk, low risk, and intermediate risk. The low-risk category, for whom skeletal muscle mass measurement is probably unnecessary, represented 28.9% of males and 9.2% of females.</p><p><strong>Conclusions: </strong>This simple predictive model provides an easily calculable tool for estimating low ASMM in daily clinical practice and can facilitate the screening for reduced skeletal muscle mass in older adults.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"129-136"},"PeriodicalIF":3.1,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13163924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Elderly Health Through Physical Activities: Insights From a Global Bibliometric Review, 1900-2023.","authors":"Hongman Wang, Bo Xie, Can Liu, Yifan Song","doi":"10.1002/agm2.70069","DOIUrl":"10.1002/agm2.70069","url":null,"abstract":"<p><strong>Objective: </strong>This article conducted a bibliometric analysis on research of older adults' health and physical activity (PA) to enrich the academic community's comprehension and research of this field.</p><p><strong>Methods: </strong>A total of 10,778 documents published from 1900 to 2023 were included. We used Citespace to analyze global research trends, identifying core journals, highlighting collaboration networks, and citation bursts within the field of physical activity and older adults' health.</p><p><strong>Results: </strong>The publications rise consistently, with close collaboration found among researchers, institutions, and countries. Developed countries made a dominant contribution. The recent research hotspots include healthy aging, the impact of physical activities on the mental health of older adults, and the utilization of virtual reality to enhance physical activity in old people.</p><p><strong>Conclusion: </strong>The study suggests that promoting physical activity among older adults is crucial for healthy aging. It emphasizes the role of technology in facilitating exercise participation and the importance of research from developing countries to advance global healthy aging strategies.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13393507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Correlates of Geriatric Depression: A Community-Based Cross-Sectional Study in Bangladesh","authors":"Md. Biplob Hossain,&nbsp;Md. Imdadul Haque,&nbsp;Md. Monir Hossain Shimul,&nbsp;Rebeka Jesmin Sarker,&nbsp;Syed Nazmus Sakib,&nbsp;Ajahar Islam Hridoy,&nbsp;Kausar Ahammed Nishat,&nbsp;Foysal Ahmed,&nbsp;Mohammed Nadir Bin Ali,&nbsp;Hafiz T. A. Khan,&nbsp;Salim Khan,&nbsp;ABM Alauddin Chowdhury","doi":"10.1002/agm2.70065","DOIUrl":"https://doi.org/10.1002/agm2.70065","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to estimate the prevalence of geriatric depression and identify its associated socio-demographic, lifestyle, health, and psychosocial determinants among community-dwelling older adults in Bangladesh.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A community-based cross-sectional study was conducted between April and December 2024 among 719 adults aged ≥ 60 years, selected by multistage random sampling across four administrative divisions. Data were collected using interviewer-administered questionnaires. Depression was assessed using the GDS-15 (cut-off ≥ 5). Logistic regression models were applied to identify determinants, and adjusted odds ratios (AORs) with 95% confidence intervals (CIs) were reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The prevalence of geriatric depression was 35.2%. Poor family bonding (AOR = 6.580, 95% CI = 3.540–12.210, <i>p</i> &lt; 0.001), financial instability (AOR = 3.660, 95% CI = 2.550–5.260, <i>p</i> &lt; 0.001), dissatisfaction with lifestyle (AOR = 3.590, 95% CI = 2.240–5.770, <i>p</i> &lt; 0.001), and daily life stress (AOR = 3.640, 95% CI = 2.560–5.190, <i>p</i> &lt; 0.001) were significant predictors. Comorbidities, lack of regular exercise, mobility, and hearing problems also increased depression risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Geriatric depression is common in Bangladesh and influenced by multidimensional determinants. Integrating geriatric mental health services into primary care and strengthening family and social support systems are essential for prevention and early management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 1","pages":"30-39"},"PeriodicalIF":2.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147567046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evolution of Symptoms in Prodromal Dementia With Lewy Bodies: A Naturalistic History Study in a Chinese Memory Clinic","authors":"Ming Zhang,&nbsp;Tao Li,&nbsp;Dag Aarsland,&nbsp;Xiaozhen Lv,&nbsp;Jing Wang,&nbsp;Teng Xie,&nbsp;Xin Yu,&nbsp;Huali Wang","doi":"10.1002/agm2.70068","DOIUrl":"https://doi.org/10.1002/agm2.70068","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Given that DLB is the second most common neurodegenerative dementia and early detection is crucial, this study sought to delineate the pre-diagnostic symptom evolution in patients from a Chinese memory clinic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Prospective patients diagnosed with probable DLB (<i>n</i> = 47, mean age at first symptom 71 years) registered at Dementia Care and Research Center, Peking University Institute of Mental Health were included. A dementia specialist performed data collection, medical history, and examination. We used the unified data form to prospectively collect the data at examinations every 3–6 months. In addition, retrospective data were extracted from medical records to identify the evolution of symptoms before diagnosis, including the first-onset symptom(s) and the time elapsed before diagnosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Most informants (<i>n</i> = 36, 76.6%) reported only one initial symptom. The most frequently reported initial symptom was memory decline (57.4%). Throughout the journey to a diagnosis, the most common symptom was visual hallucination (<i>n</i> = 29, 61.7%), followed by sleep problems and systematized delusions (both <i>n</i> = 20, 42.6%). Anxiety was the earliest recognizable individual psychiatric symptom of DLB, occurring an average of 73 months before diagnosis, followed by depression, memory decline (34 months before diagnosis), RBD, hallucinations and delusions, and motor symptoms of about 15 months before diagnosis. Fluctuating cognition, delirium, and impulsive aggressive behavior were documented relatively shortly before the diagnosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Cognitive and emotional symptoms were the most common early symptoms before a diagnosis of DLB. The findings are informative for the early detection of DLB.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 1","pages":"20-29"},"PeriodicalIF":2.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147567039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Population Analysis of Naples Prognostic Score's Association With Sarcopenia: Insights From US and Chinese Cohorts","authors":"Xinlong Ke,&nbsp;Qiaoxin Wei,&nbsp;Yijing Li,&nbsp;Jie Shen,&nbsp;Zhengli Guo,&nbsp;Bingqing Xu,&nbsp;Kaiyu Zhang,&nbsp;Juan Xia,&nbsp;Zhaoyuan Sheng,&nbsp;Yihui Xu","doi":"10.1002/agm2.70070","DOIUrl":"https://doi.org/10.1002/agm2.70070","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to evaluate the feasibility of the NPS for predicting sarcopenia in adults and to explore potential interventions or mechanistic links to mitigate sarcopenia risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included two distinct cohorts as follows: 282 patients from the geriatric department of the First People's Hospital of Kunshan in China, and 1811 community members from the National Health and Nutrition Examination Survey (NHANES) database in the United States, spanning the 2015–2016 and 2017–2018 survey cycles. One-way analysis of variance (ANOVA) was employed to assess trends between NPS levels and factors such as sex, BMI, age, and sarcopenia. In order to evaluate the sarcopenia risk factors linked to the Naples Prognostic Score (NPS), logistic regression analyses were conducted.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Comparing the group with low NPS levels, the group with high NPS levels exhibited a significantly increased risk of sarcopenia in the NHANES (<i>p</i> = 0.006) and Kunshan cohorts (<i>p</i> &lt; 0.001). In the NHANES cohort, after adjusting for covariates, a high NPS was substantially linked to a higher sarcopenia risk (odds ratio [OR] = 1.990, 95% confidence interval 1.086–3.646 for a high NPS). In the Kunshan cohort, the NPS (OR = 5.255, <i>p</i> = 0.005) was confirmed to be an independent predictor of sarcopenia, along with age (OR = 4.100, <i>p</i> &lt; 0.001), sex (OR = 4.428, <i>p</i> = 0.003), and body mass index (OR = 0.153, <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In the NHANES and Kunshan cohorts, there was a substantial correlation between greater NPS levels and an increased sarcopenia risk. This study reveals the crucial role of nutritional status and immune-inflammatory processes in the development of sarcopenia among hospitalized and elderly community individuals. Meanwhile, a simplified clinical screening tool is introduced to assess sarcopenia risk in elderly and middle-aged populations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 1","pages":"51-66"},"PeriodicalIF":2.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70070","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147563863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Satisfaction With Medication Pricing in Community Pharmacy Settings: A Cross-Sectional Study of Individuals With Comorbidities","authors":"Amelia Ravindran,&nbsp;Palanisamy Sivanandy,&nbsp;Sajesh Kalkandi Veettil,&nbsp;Priya Manirajan","doi":"10.1002/agm2.70063","DOIUrl":"https://doi.org/10.1002/agm2.70063","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The affordability of medication is a crucial factor influencing individual adherence to prescribed treatments. Fluctuating medication prices at community pharmacies can negatively affect long-term adherence and contribute to poor health outcomes. Therefore, this study was conducted to evaluate public satisfaction with medication pricing at community pharmacies and to explore public perceptions of Malaysia's medication pricing policies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study was conducted nationwide using a validated questionnaire and convenience sampling over 1 year. Participants with at least one comorbidity who purchased medications from community pharmacies were included in the study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 438 respondents, 385 met the inclusion criteria, comprising 198 females and 187 males, with the majority aged 21–30 years (<i>n</i> = 121; 31.4%) and a mean age of 41 years (±15.8). Dizziness (<i>n</i> = 26; 6.8%) and asthma (<i>n</i> = 19; 4.9%) were the most common single medical conditions, while 73 respondents (18.96%) reported multiple conditions. Paracetamol (<i>n</i> = 51; 13.2%) was the most frequently prescribed monotherapy, while Amlodipine with Metformin (<i>n</i> = 6; 1.6%) was the most common combination therapy. The majority (<i>n</i> = 287; 74.5%) could afford medications comfortably, but 25.5% (<i>n</i> = 98) encountered challenges due to high costs, price discrepancies, and financial obligations. Most respondents (<i>n</i> = 275; 71.4%) believed that community pharmacy pricing was fair, while 28.6% (<i>n</i> = 110) disagreed due to high costs and inconsistencies. Overall, satisfaction with community pharmacy pricing was moderate (3.06 ± 0.93, <i>p</i> = 0.207).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Strict enforcement of pricing controls is essential in the country to ensure life-saving medications remain accessible to all economic groups and to promote adherence to prescribed treatments.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 1","pages":"40-50"},"PeriodicalIF":2.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147564622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hainan Longevity Model, Senile Degeneration, Cognitive Disability and Healthy Longevity","authors":"Shihui Fu,&nbsp;Jiacai Lin,&nbsp;Qianshuo Liu,&nbsp;Lianbo Gao,&nbsp;Zhirui Li,&nbsp;Feng Lin,&nbsp;Leixing Xie,&nbsp;Xiong Liu,&nbsp;Wenkai Xiao,&nbsp;Qiwei Zhu,&nbsp;Fan Wang,&nbsp;Jin Zheng,&nbsp;Yali Zhao,&nbsp;Xiaolei Chen,&nbsp;Yao Yao,&nbsp;Long Feng","doi":"10.1002/agm2.70054","DOIUrl":"https://doi.org/10.1002/agm2.70054","url":null,"abstract":"<p>The aging process is an inevitable and universal phenomenon characterized by a decline in function that all living organisms must undergo. The challenges posed by population aging, along with senile degeneration and cognitive disability, have emerged as pressing public health issues that require urgent attention on a global scale. The ability of older adults to maintain robust physiological function may confer resistance against the risk factors associated with senile degeneration and cognitive disability. Investigating centenarians who exemplify healthy longevity and their underlying mechanisms of functional resilience can aid in formulating preventive strategies aimed at achieving health, extending the lifespan, and identifying the pathways for promoting healthy longevity in the context of population aging. Hainan is the province in China where the largest number of centenarians and the highest density of centenarians are distributed. There are unique advantages to studying the centenarian population in Hainan. Hainan centenarians not only live in the natural environment with high oxygen concentration and dense greenery coverage but also inherit favorable genetic traits and adopt healthy lifestyles, including social participation, good education, stable emotion, balanced nutrition, moderate exercise, reasonable sleep, optimized senses, coordinated metabolism, improved immunity, prevention and treatment of chronic diseases, and joint treatment of comorbidities. These factors work together to form the Hainan longevity model (HLM), which is expected to play key roles in promoting healthy longevity and provide scientific evidence for achieving healthy longevity in the older populations. It will also contribute to the construction of a healthy human society and has important social value and practical significance.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 1","pages":"67-81"},"PeriodicalIF":2.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147567040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming Brain Healthism: Providing Support for Healthy Lifestyles","authors":"Timothy Daly","doi":"10.1002/agm2.70064","DOIUrl":"https://doi.org/10.1002/agm2.70064","url":null,"abstract":"&lt;p&gt;“Brain healthism” is a moralizing bias in dementia research and policy that places the onus for responsibility for brain health on individuals to live healthy lifestyles, while overlooking environmental drivers of poor brain health such as poverty, pollution and privation [&lt;span&gt;1&lt;/span&gt;]. It is a highly present and misleading narrative [&lt;span&gt;2&lt;/span&gt;], as evidenced by skewed interpretations of a recent high-impact study, the “US POINTER” supported by the Alzheimer's Association and Worldwide FINGERS international research initiative studying lifestyle interventions for brain health in older adults [&lt;span&gt;3&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;In US POINTER, 2111 participants at risk of cognitive decline aged 60 to 79 years with a sedentary lifestyle, suboptimal diet, and at least two additional criteria (family history of memory impairment, cardiometabolic risk, race and ethnicity, older age, and sex) were randomized into two groups: two years of a structured versus self-guided multidomain lifestyle interventions for brain health [&lt;span&gt;3&lt;/span&gt;]. Global cognition increased from baseline over time in both groups, but crucially, the mean rate of increase per year was statistically significantly greater for the structured group than the self-guided group [&lt;span&gt;3&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Healthist interpretations limit the public health value of this study. The Alzheimer's Association lists the “US POINTER Brain Health Recipe” (https://www.alz.org/getmedia/5d1826c1-1ddd-49ca-badc-44deed8eee40/uspointerbrainhealthrecipe.pdf; Accessed 9th December 2025) on its website consisting of physical exercise, cognitive exercise, health monitoring, and nutrition. According to the Cambridge dictionary, a recipe is “a set of instructions telling you how to prepare and cook food.” This “recipe” framing places responsibility at an individual level (“you”) and is instruction-based, that is, brain healthism. The structured group received “38 facilitated peer team meetings over 2 years, with education, goal-setting, and accountability to support the health behaviors,” whereas the self-guided group received “6 facilitated peer team meetings over 2 years to provide the support” (p. 3, [&lt;span&gt;3&lt;/span&gt;]). So the entire variable of the structured, supported multi-domain intervention (32 extra meetings; exercise in a community center; the MIND diet; supported cognitive and social stimulation; twice-yearly medical advisor appointments) was the randomized factor causally responsible for group differences. It is incorrect to isolate the multi-domain intervention “recipe” as the active component. The POINTER study group differences provide an analogy of social advantage and empirically confirm that more advantaged people (e.g., with more social support) would gain the most from lifestyle-only approaches, worsening pre-existing brain health inequalities [&lt;span&gt;4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Therefore, policy makers and dementia researchers have to choose between brain healthism and a public health approach [&lt;span&gt;4&lt;/s","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 1","pages":"82-83"},"PeriodicalIF":2.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147565970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}