Aging Medicine最新文献

{"title":"Impact of Deprescribing Among Older Adults in Primary Care Settings: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Christina Malini Christopher, Bhuvan Kc, Mark Wing Loong Cheong, Rajeev Shrestha, Sunil Shrestha, Juman Dujaili, Ali Blebil","doi":"10.1002/agm2.70075","DOIUrl":"10.1002/agm2.70075","url":null,"abstract":"<p><strong>Background: </strong>Deprescribing is a systematic approach aimed at reducing the number of medications that are no longer beneficial or appropriate. This study aims to assess the various types of deprescribing and the outcomes among older adults in primary health care. The electronic search for original articles was conducted using the following electronic databases: MEDLINE, EMBASE, Scopus, PsycINFO, and Global Health. The types of deprescribing interventions and their outcomes in older adults were assessed and compared with those of non-intervention. The risk of bias was assessed using the Robins tool. Eighteen randomized controlled trials were included after full-text screening. These studies evaluated a range of deprescribing interventions implemented in primary healthcare settings. The interventions included medication reviews, academic detailing, pharmacist-led deprescribing, computerized decision-support tools, structured education, patient-centered communication, and coordinated medication risk management. Quantitative analysis revealed that two studies reported a statistically significant reduction in patient falls due to deprescribing (OR: 0.67; 95% CI: [0.46, 0.98]; I² = 0%; <i>p</i> = 0.04). Sensitivity analysis further demonstrated that deprescribing significantly reduced the average number of medications used by older adults (MD: 0.17; 95% CI: [0.03, 0.32]; <i>p</i> = 0.02) and was associated with a significant decrease in hospitalisations in this population (RR: 1.40; 95% CI: [1.08, 1.80]; <i>p</i> = 0.01). Deprescribing interventions in primary care have been proven to result in a modest reduction in the number of medications prescribed to older adults and could help reduce falls, with potential benefits for reducing hospitalization.</p><p><strong>Trial registration: </strong>Prospero CRD42023464445.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"214-223"},"PeriodicalIF":3.1,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13163933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147933994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"214-223"},"PeriodicalIF":2.5,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148091702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Artificial Intelligence in Medication Management for Older Adults: A Systematic Review.","authors":"Dipak Chandra Das, Moustaq Karim Khan Rony, Shovit Dutta, Md Sami Al Zubair Zujbe, Tapan Bhattacharjee, Niloy Debnath, Shabbir Abdullah Maruf, Chowdhury Galib Mortuza, Farhana Rahman, Akash Das","doi":"10.1002/agm2.70074","DOIUrl":"10.1002/agm2.70074","url":null,"abstract":"<p><p>Older adults face increased risks of medication non-adherence, adverse drug events, and polypharmacy due to chronic health conditions and complex drug regimens. Traditional medication management approaches often fall short in addressing these challenges. Artificial intelligence (AI) has emerged as a promising tool for enhancing medication safety and personalization in geriatric care. This systematic review aimed to explore the role of AI in medication management for older adults, highlighting its effectiveness, usability, ethical implications, and integration within healthcare systems. Following PRISMA guidelines, a comprehensive search was conducted across six databases (PubMed, Scopus, Web of Science, CINAHL, IEEE Xplore, and Cochrane Library) for studies published between January 2015 and March 2025. Eligible studies included qualitative, quantitative, and mixed-methods research on AI-based medication interventions for individuals aged 60 and above. Data were synthesized thematically. Twenty-nine studies were included. Five major themes emerged: (1) AI's ability to enhance adherence through smart reminders and automation; (2) personalized and predictive capabilities in managing complex regimens; (3) design and usability challenges among older adults; (4) ethical concerns related to trust, privacy, and autonomy; and (5) the importance of seamless integration within clinical workflows. Cross-cutting observations emphasized the need for hybrid care models, inclusive design, and digital literacy training. AI has the potential to transform geriatric medication management. However, its success depends on ethical implementation, user-centered design, healthcare integration, and attention to equity. Long-term evaluations are essential to ensure sustainable and inclusive outcomes.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"196-213"},"PeriodicalIF":3.1,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13163944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"196-213"},"PeriodicalIF":2.5,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148091701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"168-184"},"PeriodicalIF":2.5,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148088489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced CB1 Cannabinoid Receptor Expression in Alzheimer's Disease and Transgenic Mouse Models.","authors":"Nike von Borcke, Amrei Vivian Purwien, Annik Steiert, Henrike Hasecke, Yvonne Bouter","doi":"10.1002/agm2.70080","DOIUrl":"10.1002/agm2.70080","url":null,"abstract":"<p><strong>Objectives: </strong>Therefore, in the present study, the CB1 receptor (CB1R) expression in the hippocampal and cortical tissue of a clinically and neuropathologically characterized cohort of AD patients was analyzed.</p><p><strong>Methods: </strong>Post-mortem brain tissue from patients with sporadic AD and non-demented control subjects was analyzed immunohistochemically, focusing on the hippocampus, medial frontal gyrus, and superior temporal gyrus. CB1R expression levels were measured and correlated with neuropathological hallmarks of AD (amyloid-β and tau pathology), neuroinflammatory markers (GFAP and IBA1), cognitive status (Reisberg scale), ApoE genotype, and age. Complementary analyzes were performed in two AD mouse models (5xFAD and Tg4-42).</p><p><strong>Results: </strong>CB1R expression was significantly reduced in the hippocampus, medial frontal gyrus, and superior temporal gyrus of AD patients. CB1R levels negatively correlated with both amyloid-β and tau pathology but showed no association with cognitive performance, neuroinflammatory markers, age, or ApoE genotype. Consistent with the human findings, CB1R expression was also reduced in the cortex of 5xFAD mice and in the hippocampus of Tg4-42 mice.</p><p><strong>Conclusions: </strong>Our data demonstrate a region-specific downregulation of CB1R in both human AD brains and transgenic mouse models, which correlates with key neuropathological hallmarks of the disease. These findings suggest a potential role for CB1R in AD pathophysiology and support further investigation into its utility as a biomarker or therapeutic target.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"168-184"},"PeriodicalIF":3.1,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13163938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"185-195"},"PeriodicalIF":2.5,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148089379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"99-110"},"PeriodicalIF":2.5,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148089380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foreign Language Learning in Older Adults Modifies Resting-State Functional Connectivity Between the Subcortical Structures and the Cortex.","authors":"Giovanna Bubbico, Federica Tomaiuolo, Carlo Sestieri, Golnoush Akhlaghipour, Alberto Granzotto, Antonio Ferretti, Mauro Gianni Perrucci, Stefano L Sensi, Stefano Delli Pizzi","doi":"10.1002/agm2.70073","DOIUrl":"10.1002/agm2.70073","url":null,"abstract":"<p><strong>Objectives: </strong>Neuroimaging studies suggest that Foreign Language Learning (FLL) influences resting-state functional connectivity (rs-FC) within the neocortex, but its effects on subcortical-cortical connectivity remain unclear. We hypothesize that FLL may specifically affect the rs-FC of subcortical regions involved in integrating cortical networks, leading to adaptive changes in overall brain connectivity.</p><p><strong>Methods: </strong>Twenty-seven healthy older adults were randomly assigned to either a 16-week FLL intervention or a control condition. Resting-state fMRI data were analyzed using seed-based connectivity methods targeting seven subcortical structures. Group differences in rs-FC were examined alongside correlations with maps of the expression of receptors/genes related to plasticity and behavioral performance.</p><p><strong>Results: </strong>FLL induced specific and distributed changes in rs-FC between subcortical and cortical areas. Notably, thalamocortical circuits showed both increases and decreases in connectivity with regions of the default mode network. Increases of striato-cortical connectivity targeted frontal regions. Changes of connectivity spatially overlapped with cortical areas enriched in CB1 receptor density and NTRK2 gene expression. Importantly, FLL also modulated pallidal connectivity, a change that was significantly associated with improvements in semantic memory.</p><p><strong>Conclusions: </strong>The FLL program selectively reorganizes subcortico-cortical networks, particularly those involving the thalamus and the caudate, in a way that supports the biological plausibility of FLL-induced functional plasticity. The alignment with plasticity-related molecular markers and the observed cognitive improvements further support the potential of FLL as an ecologically valid strategy for preserving brain function in later life.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"99-110"},"PeriodicalIF":3.1,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13163939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Extracellular Vesicles MicroRNAs in Sarcopenia: From Aging to Multi-Morbidity.","authors":"Bingyu Huang, Zhao Peng, Lin Kang","doi":"10.1002/agm2.70078","DOIUrl":"10.1002/agm2.70078","url":null,"abstract":"<p><p>Sarcopenia, defined as progressive loss of skeletal muscle mass and function, occurs during aging and has also been recognized for its detrimental effects in various disease states. Its prevention and management represent a critical aspect of geriatric care and multi-morbidity management. As a systemic disorder, extracellular vesicle-transported miRNAs mediate both intrinsic muscle pathology and multifaceted organ crosstalk. This review comprehensively summarizes and discusses the roles of EVs-miRNAs in sarcopenia under physiological aging and pathological conditions, and their emerging potential as diagnostic biomarkers and engineered therapeutic targets.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"185-195"},"PeriodicalIF":3.1,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13163945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147933987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}