Aging Medicine最新文献

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"158-167"},"PeriodicalIF":2.5,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148065172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretation of A Focus Shift From Sarcopenia to Muscle Health in the Asian Working Group for Sarcopenia 2025 Consensus Update.","authors":"Bi Jianghan, Li Jiaojiao, Kang Lin","doi":"10.1002/agm2.70082","DOIUrl":"10.1002/agm2.70082","url":null,"abstract":"<p><p>The Asian Sarcopenia Working Group has released its latest 2025 consensus update. This narrative review interprets key changes in the AWGS 2025 consensus including: for the first time the working group establishes a conceptual framework centered on muscle health promotion, proposes diagnostic thresholds for sarcopenia in middle-aged people, simplifies the diagnostic criteria for sarcopenia to only require the concurrence of low muscle mass and low muscle strength, and regards physical performance as an outcome indicator. The consensus aims to identify and intervene in muscle decline at an early stage, providing directional guidance for muscle health management across the life course.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"89-98"},"PeriodicalIF":3.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13163934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147933997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Outcomes After Total Arch Replacement With Frozen Elephant Trunk in Elderly Patients With Acute Type A Aortic Dissection.","authors":"Jiajun Liang, Yuan Xue, Yeting Lou, Hao Han, Xiaohan Zhong, Zhou Liu, Tianxu Han, Meili Wang, Wenjian Jiang, Hongjia Zhang, Haiyang Li, Yuanfei Zhao","doi":"10.1002/agm2.70076","DOIUrl":"10.1002/agm2.70076","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The clinical efficacy and early outcomes of total arch replacement with frozen elephant trunk (TAR+FET) in elderly patients presenting with acute type A aortic dissection (ATAAD) remain incompletely characterized. This study aimed to comprehensively evaluate early clinical outcomes and perioperative risk profiles in elderly patients undergoing TAR+FET for ATAAD, thereby addressing gaps in the literature and providing evidence to guide surgical decision-making in this high-risk population.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A multicenter retrospective analysis was conducted involving 1634 patients who underwent TAR+FET for ATAAD between 2015 and 2023 across seven cardiovascular centers. Patients were categorized into elderly (≥ 60 years, &lt;i&gt;n&lt;/i&gt; = 258) and non-elderly (&lt; 60 years, &lt;i&gt;n&lt;/i&gt; = 1376) groups. Baseline characteristics, operative details, and early outcomes were compared between groups before propensity score matching (PSM). A 1:2 PSM established a balanced cohort of 699 patients (elderly, &lt;i&gt;n&lt;/i&gt; = 245; non-elderly, &lt;i&gt;n&lt;/i&gt; = 454), in which postoperative complications and survival were compared. To evaluate the independent prognostic impact of age, multivariable Cox proportional hazards models with incremental covariate adjustments were applied.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Before PSM, elderly patients had higher prevalences of coronary artery disease, diabetes, and hyperlipidemia, with significantly longer intensive care unit (ICU) stay, prolonged ventilation time, and lower 30-day survival compared with non-elderly patients. After PSM, baseline covariates were well balanced; however, elderly patients continued to demonstrate worse perioperative outcomes, including longer ICU stay (68 [35-162] vs. 47 [28-113] h, &lt;i&gt;p&lt;/i&gt; = 0.001), prolonged ventilation time (49 [21-111] vs. 38 [18-86] h, &lt;i&gt;p&lt;/i&gt; &lt; 0.001), and higher incidences of reintubation, tracheostomy, respiratory failure, acute kidney injury (AKI), and dialysis (all &lt;i&gt;p&lt;/i&gt; &lt; 0.010). Kaplan-Meier analysis revealed significantly lower 30-day survival in the elderly group (86.5% vs. 93.6%, &lt;i&gt;p&lt;/i&gt; = 0.002). Multivariable Cox regression identified age ≥ 60 years as an independent predictor of mortality (hazard ratio = 2.286, 95% confidence interval: 1.361-3.840, &lt;i&gt;p&lt;/i&gt; = 0.002). Within the elderly subgroup, non-survivors were older, had longer operative and cardiopulmonary bypass times, and experienced substantially higher rates of severe postoperative complications-particularly neurological injury, dialysis-requiring AKI, arrhythmia, and respiratory failure-than survivors.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Even after adjustment for baseline characteristics, elderly patients undergoing TAR+FET have higher risks of perioperative complications and early mortality than non-elderly patients. This unfavorable prognosis likely reflects reduced physiological reserve rather than surgical factors alone. Future strategies should emphasize individualize","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 ","pages":"111-128"},"PeriodicalIF":3.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13163943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"89-98"},"PeriodicalIF":2.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148098615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics of Geriatric Asthma in Guangxi of China: A Retrospective Comparative Descriptive Study.","authors":"Mengxia Gu, Qixiang Sun, Yujia Huang, Yuetian Deng, Xiaohong Jiang","doi":"10.1002/agm2.70083","DOIUrl":"10.1002/agm2.70083","url":null,"abstract":"<p><strong>Objective: </strong>The research analyzed the clinical characteristics of geriatric and nongeriatric asthma cases, aiming to provide new insights into the diagnosis and management of geriatric asthma for clinicians.</p><p><strong>Methods: </strong>This retrospective study analyzed data from the First Affiliated Hospital of Guangxi Medical University database (2012-2022), including 130 geriatric (≥ 65 years) and 130 nongeriatric (18-64 years) asthma patients. Both cohorts were stratified into fixed (FAO) and reversible (RAO) airflow obstruction subgroups based on spirometry-confirmed airflow limitation patterns. Demographic and clinical symptom data were extracted from electronic health records.</p><p><strong>Results: </strong>Geriatric asthmatics are mainly characterized by a greater prevalence in females (<i>n</i> = 78, 60%), increased cough (<i>n</i> = 123, 94.6%) and sputum (<i>n</i> = 116, 89.2%), poorer lung function (VC: 2.06 ± 0.65, FVC: 2.05 ± 0.64, FEV₁:1.22 ± 0.49, PEF: 3.53 ± 1.59, all <i>p</i> < 0.05), elevated neutrophils ratios (66.7 ± 13.4, <i>p</i> < 0.05), and higher C-reactive protein (CRP) levels (5.1 (11.1), <i>p</i> < 0.05). Geriatric asthmatics had longer average hospitalization days (9.9 ± 3.9, <i>p</i> < 0.05), higher sensitization rates to dust or irritant gases (<i>n</i> = 20, 15.4%, <i>p</i> < 0.05), and had more comorbidities compared to nongeriatric asthmatics. A history of asthma lasting > 20 years was identified as an independent risk factor for FAO in geriatric asthmatics (OR = 8.578, 95% CI = 1.610-45.741, <i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>Geriatric asthmatics exhibit more comorbidities, poorer lung function, higher neutrophil ratios, and elevated CRP levels. They also experience longer hospital stays and are likely to be sensitized to dust or irritant gases. A longer duration of asthma significantly increases the risk of developing FAO in geriatric asthmatics.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"148-157"},"PeriodicalIF":3.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13163941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147933986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"137-147"},"PeriodicalIF":2.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148097349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Treatment and Outcomes in Resectable Early-Stage Non-Small Cell Cancer: THASSOS-INTL Australia Cohort.","authors":"Pei Ding, Kevin Jasas, Victoria Bray, Abhijit Pal, Rebecca Moor","doi":"10.1002/agm2.70077","DOIUrl":"10.1002/agm2.70077","url":null,"abstract":"<p><strong>Objectives: </strong>Limited data exist on real-world treatment strategies and their impact on survival in Australian patients with NSCLC. THASSOS-INL (NCT04808050) evaluated the treatment patterns and survival outcomes in patients with early-stage NSCLC.</p><p><strong>Methods: </strong>Australia cohort of THASSOS-INTL, non-interventional, multicenter, retrospective study enrolled patients aged ≥ 18 years diagnosed with stage IA-IIIB resectable NSCLC between January 2013 and December 2017. The primary outcomes included treatment patterns and associated 3-year survival rates. Secondary endpoints included clinico-demographic characteristics and their association with overall survival (OS).</p><p><strong>Results: </strong>Of 199 patients recruited (median [range] age: 67.0 [35.0-88.0] years), 53.8% were males, 87.4% were current smokers/ex-smokers, and 52.2% had an ECOG score of ≤ 1. A total of 42.2% patients had stage I, 28.1% had stage II, and 29.6% had stage III NSCLC. Adenocarcinoma was the predominant (56.8%) histological subtype. Overall, 97.0% patients underwent surgery. Neoadjuvant therapy was reported in 9.5%; adjuvant therapy was reported in 39.2%. The overall median OS was 6.0 years (95% CI: 5.200 NE) with a median 3 year survival probability rate of 70.5% (95% CI: 64.4%-77.2%). Age, increasing stages of NSCLC, disease progression, and <i>EGFR</i> mutations were associated with significant worsening of OS.</p><p><strong>Conclusions: </strong>The study underscores the diverse treatment approaches prior to approval of immuno-targeted therapy, showing that fewer than half of the patients received AT with only a quarter of those receiving adjuvant ST. The study highlights the need for integrating molecular diagnostics, improving access to novel therapies, and a multidisciplinary team approach to improve survival in these patients.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"137-147"},"PeriodicalIF":3.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13163932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"111-128"},"PeriodicalIF":2.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148097350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"148-157"},"PeriodicalIF":2.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148097351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Deprescribing Among Older Adults in Primary Care Settings: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Christina Malini Christopher, Bhuvan Kc, Mark Wing Loong Cheong, Rajeev Shrestha, Sunil Shrestha, Juman Dujaili, Ali Blebil","doi":"10.1002/agm2.70075","DOIUrl":"10.1002/agm2.70075","url":null,"abstract":"<p><strong>Background: </strong>Deprescribing is a systematic approach aimed at reducing the number of medications that are no longer beneficial or appropriate. This study aims to assess the various types of deprescribing and the outcomes among older adults in primary health care. The electronic search for original articles was conducted using the following electronic databases: MEDLINE, EMBASE, Scopus, PsycINFO, and Global Health. The types of deprescribing interventions and their outcomes in older adults were assessed and compared with those of non-intervention. The risk of bias was assessed using the Robins tool. Eighteen randomized controlled trials were included after full-text screening. These studies evaluated a range of deprescribing interventions implemented in primary healthcare settings. The interventions included medication reviews, academic detailing, pharmacist-led deprescribing, computerized decision-support tools, structured education, patient-centered communication, and coordinated medication risk management. Quantitative analysis revealed that two studies reported a statistically significant reduction in patient falls due to deprescribing (OR: 0.67; 95% CI: [0.46, 0.98]; I² = 0%; <i>p</i> = 0.04). Sensitivity analysis further demonstrated that deprescribing significantly reduced the average number of medications used by older adults (MD: 0.17; 95% CI: [0.03, 0.32]; <i>p</i> = 0.02) and was associated with a significant decrease in hospitalisations in this population (RR: 1.40; 95% CI: [1.08, 1.80]; <i>p</i> = 0.01). Deprescribing interventions in primary care have been proven to result in a modest reduction in the number of medications prescribed to older adults and could help reduce falls, with potential benefits for reducing hospitalization.</p><p><strong>Trial registration: </strong>Prospero CRD42023464445.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"214-223"},"PeriodicalIF":3.1,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13163933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147933994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}