Aging Medicine最新文献

{"title":"Prevalence and Correlates of Geriatric Depression: A Community-Based Cross-Sectional Study in Bangladesh","authors":"Md. Biplob Hossain,&nbsp;Md. Imdadul Haque,&nbsp;Md. Monir Hossain Shimul,&nbsp;Rebeka Jesmin Sarker,&nbsp;Syed Nazmus Sakib,&nbsp;Ajahar Islam Hridoy,&nbsp;Kausar Ahammed Nishat,&nbsp;Foysal Ahmed,&nbsp;Mohammed Nadir Bin Ali,&nbsp;Hafiz T. A. Khan,&nbsp;Salim Khan,&nbsp;ABM Alauddin Chowdhury","doi":"10.1002/agm2.70065","DOIUrl":"https://doi.org/10.1002/agm2.70065","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to estimate the prevalence of geriatric depression and identify its associated socio-demographic, lifestyle, health, and psychosocial determinants among community-dwelling older adults in Bangladesh.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A community-based cross-sectional study was conducted between April and December 2024 among 719 adults aged ≥ 60 years, selected by multistage random sampling across four administrative divisions. Data were collected using interviewer-administered questionnaires. Depression was assessed using the GDS-15 (cut-off ≥ 5). Logistic regression models were applied to identify determinants, and adjusted odds ratios (AORs) with 95% confidence intervals (CIs) were reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The prevalence of geriatric depression was 35.2%. Poor family bonding (AOR = 6.580, 95% CI = 3.540–12.210, <i>p</i> &lt; 0.001), financial instability (AOR = 3.660, 95% CI = 2.550–5.260, <i>p</i> &lt; 0.001), dissatisfaction with lifestyle (AOR = 3.590, 95% CI = 2.240–5.770, <i>p</i> &lt; 0.001), and daily life stress (AOR = 3.640, 95% CI = 2.560–5.190, <i>p</i> &lt; 0.001) were significant predictors. Comorbidities, lack of regular exercise, mobility, and hearing problems also increased depression risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Geriatric depression is common in Bangladesh and influenced by multidimensional determinants. Integrating geriatric mental health services into primary care and strengthening family and social support systems are essential for prevention and early management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 1","pages":"30-39"},"PeriodicalIF":2.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147567046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evolution of Symptoms in Prodromal Dementia With Lewy Bodies: A Naturalistic History Study in a Chinese Memory Clinic","authors":"Ming Zhang,&nbsp;Tao Li,&nbsp;Dag Aarsland,&nbsp;Xiaozhen Lv,&nbsp;Jing Wang,&nbsp;Teng Xie,&nbsp;Xin Yu,&nbsp;Huali Wang","doi":"10.1002/agm2.70068","DOIUrl":"https://doi.org/10.1002/agm2.70068","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Given that DLB is the second most common neurodegenerative dementia and early detection is crucial, this study sought to delineate the pre-diagnostic symptom evolution in patients from a Chinese memory clinic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Prospective patients diagnosed with probable DLB (<i>n</i> = 47, mean age at first symptom 71 years) registered at Dementia Care and Research Center, Peking University Institute of Mental Health were included. A dementia specialist performed data collection, medical history, and examination. We used the unified data form to prospectively collect the data at examinations every 3–6 months. In addition, retrospective data were extracted from medical records to identify the evolution of symptoms before diagnosis, including the first-onset symptom(s) and the time elapsed before diagnosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Most informants (<i>n</i> = 36, 76.6%) reported only one initial symptom. The most frequently reported initial symptom was memory decline (57.4%). Throughout the journey to a diagnosis, the most common symptom was visual hallucination (<i>n</i> = 29, 61.7%), followed by sleep problems and systematized delusions (both <i>n</i> = 20, 42.6%). Anxiety was the earliest recognizable individual psychiatric symptom of DLB, occurring an average of 73 months before diagnosis, followed by depression, memory decline (34 months before diagnosis), RBD, hallucinations and delusions, and motor symptoms of about 15 months before diagnosis. Fluctuating cognition, delirium, and impulsive aggressive behavior were documented relatively shortly before the diagnosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Cognitive and emotional symptoms were the most common early symptoms before a diagnosis of DLB. The findings are informative for the early detection of DLB.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 1","pages":"20-29"},"PeriodicalIF":2.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147567039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Population Analysis of Naples Prognostic Score's Association With Sarcopenia: Insights From US and Chinese Cohorts","authors":"Xinlong Ke,&nbsp;Qiaoxin Wei,&nbsp;Yijing Li,&nbsp;Jie Shen,&nbsp;Zhengli Guo,&nbsp;Bingqing Xu,&nbsp;Kaiyu Zhang,&nbsp;Juan Xia,&nbsp;Zhaoyuan Sheng,&nbsp;Yihui Xu","doi":"10.1002/agm2.70070","DOIUrl":"https://doi.org/10.1002/agm2.70070","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to evaluate the feasibility of the NPS for predicting sarcopenia in adults and to explore potential interventions or mechanistic links to mitigate sarcopenia risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included two distinct cohorts as follows: 282 patients from the geriatric department of the First People's Hospital of Kunshan in China, and 1811 community members from the National Health and Nutrition Examination Survey (NHANES) database in the United States, spanning the 2015–2016 and 2017–2018 survey cycles. One-way analysis of variance (ANOVA) was employed to assess trends between NPS levels and factors such as sex, BMI, age, and sarcopenia. In order to evaluate the sarcopenia risk factors linked to the Naples Prognostic Score (NPS), logistic regression analyses were conducted.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Comparing the group with low NPS levels, the group with high NPS levels exhibited a significantly increased risk of sarcopenia in the NHANES (<i>p</i> = 0.006) and Kunshan cohorts (<i>p</i> &lt; 0.001). In the NHANES cohort, after adjusting for covariates, a high NPS was substantially linked to a higher sarcopenia risk (odds ratio [OR] = 1.990, 95% confidence interval 1.086–3.646 for a high NPS). In the Kunshan cohort, the NPS (OR = 5.255, <i>p</i> = 0.005) was confirmed to be an independent predictor of sarcopenia, along with age (OR = 4.100, <i>p</i> &lt; 0.001), sex (OR = 4.428, <i>p</i> = 0.003), and body mass index (OR = 0.153, <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In the NHANES and Kunshan cohorts, there was a substantial correlation between greater NPS levels and an increased sarcopenia risk. This study reveals the crucial role of nutritional status and immune-inflammatory processes in the development of sarcopenia among hospitalized and elderly community individuals. Meanwhile, a simplified clinical screening tool is introduced to assess sarcopenia risk in elderly and middle-aged populations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 1","pages":"51-66"},"PeriodicalIF":2.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70070","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147563863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Satisfaction With Medication Pricing in Community Pharmacy Settings: A Cross-Sectional Study of Individuals With Comorbidities","authors":"Amelia Ravindran,&nbsp;Palanisamy Sivanandy,&nbsp;Sajesh Kalkandi Veettil,&nbsp;Priya Manirajan","doi":"10.1002/agm2.70063","DOIUrl":"https://doi.org/10.1002/agm2.70063","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The affordability of medication is a crucial factor influencing individual adherence to prescribed treatments. Fluctuating medication prices at community pharmacies can negatively affect long-term adherence and contribute to poor health outcomes. Therefore, this study was conducted to evaluate public satisfaction with medication pricing at community pharmacies and to explore public perceptions of Malaysia's medication pricing policies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study was conducted nationwide using a validated questionnaire and convenience sampling over 1 year. Participants with at least one comorbidity who purchased medications from community pharmacies were included in the study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 438 respondents, 385 met the inclusion criteria, comprising 198 females and 187 males, with the majority aged 21–30 years (<i>n</i> = 121; 31.4%) and a mean age of 41 years (±15.8). Dizziness (<i>n</i> = 26; 6.8%) and asthma (<i>n</i> = 19; 4.9%) were the most common single medical conditions, while 73 respondents (18.96%) reported multiple conditions. Paracetamol (<i>n</i> = 51; 13.2%) was the most frequently prescribed monotherapy, while Amlodipine with Metformin (<i>n</i> = 6; 1.6%) was the most common combination therapy. The majority (<i>n</i> = 287; 74.5%) could afford medications comfortably, but 25.5% (<i>n</i> = 98) encountered challenges due to high costs, price discrepancies, and financial obligations. Most respondents (<i>n</i> = 275; 71.4%) believed that community pharmacy pricing was fair, while 28.6% (<i>n</i> = 110) disagreed due to high costs and inconsistencies. Overall, satisfaction with community pharmacy pricing was moderate (3.06 ± 0.93, <i>p</i> = 0.207).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Strict enforcement of pricing controls is essential in the country to ensure life-saving medications remain accessible to all economic groups and to promote adherence to prescribed treatments.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 1","pages":"40-50"},"PeriodicalIF":2.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147564622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hainan Longevity Model, Senile Degeneration, Cognitive Disability and Healthy Longevity","authors":"Shihui Fu,&nbsp;Jiacai Lin,&nbsp;Qianshuo Liu,&nbsp;Lianbo Gao,&nbsp;Zhirui Li,&nbsp;Feng Lin,&nbsp;Leixing Xie,&nbsp;Xiong Liu,&nbsp;Wenkai Xiao,&nbsp;Qiwei Zhu,&nbsp;Fan Wang,&nbsp;Jin Zheng,&nbsp;Yali Zhao,&nbsp;Xiaolei Chen,&nbsp;Yao Yao,&nbsp;Long Feng","doi":"10.1002/agm2.70054","DOIUrl":"https://doi.org/10.1002/agm2.70054","url":null,"abstract":"<p>The aging process is an inevitable and universal phenomenon characterized by a decline in function that all living organisms must undergo. The challenges posed by population aging, along with senile degeneration and cognitive disability, have emerged as pressing public health issues that require urgent attention on a global scale. The ability of older adults to maintain robust physiological function may confer resistance against the risk factors associated with senile degeneration and cognitive disability. Investigating centenarians who exemplify healthy longevity and their underlying mechanisms of functional resilience can aid in formulating preventive strategies aimed at achieving health, extending the lifespan, and identifying the pathways for promoting healthy longevity in the context of population aging. Hainan is the province in China where the largest number of centenarians and the highest density of centenarians are distributed. There are unique advantages to studying the centenarian population in Hainan. Hainan centenarians not only live in the natural environment with high oxygen concentration and dense greenery coverage but also inherit favorable genetic traits and adopt healthy lifestyles, including social participation, good education, stable emotion, balanced nutrition, moderate exercise, reasonable sleep, optimized senses, coordinated metabolism, improved immunity, prevention and treatment of chronic diseases, and joint treatment of comorbidities. These factors work together to form the Hainan longevity model (HLM), which is expected to play key roles in promoting healthy longevity and provide scientific evidence for achieving healthy longevity in the older populations. It will also contribute to the construction of a healthy human society and has important social value and practical significance.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 1","pages":"67-81"},"PeriodicalIF":2.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147567040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming Brain Healthism: Providing Support for Healthy Lifestyles","authors":"Timothy Daly","doi":"10.1002/agm2.70064","DOIUrl":"https://doi.org/10.1002/agm2.70064","url":null,"abstract":"&lt;p&gt;“Brain healthism” is a moralizing bias in dementia research and policy that places the onus for responsibility for brain health on individuals to live healthy lifestyles, while overlooking environmental drivers of poor brain health such as poverty, pollution and privation [&lt;span&gt;1&lt;/span&gt;]. It is a highly present and misleading narrative [&lt;span&gt;2&lt;/span&gt;], as evidenced by skewed interpretations of a recent high-impact study, the “US POINTER” supported by the Alzheimer's Association and Worldwide FINGERS international research initiative studying lifestyle interventions for brain health in older adults [&lt;span&gt;3&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;In US POINTER, 2111 participants at risk of cognitive decline aged 60 to 79 years with a sedentary lifestyle, suboptimal diet, and at least two additional criteria (family history of memory impairment, cardiometabolic risk, race and ethnicity, older age, and sex) were randomized into two groups: two years of a structured versus self-guided multidomain lifestyle interventions for brain health [&lt;span&gt;3&lt;/span&gt;]. Global cognition increased from baseline over time in both groups, but crucially, the mean rate of increase per year was statistically significantly greater for the structured group than the self-guided group [&lt;span&gt;3&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Healthist interpretations limit the public health value of this study. The Alzheimer's Association lists the “US POINTER Brain Health Recipe” (https://www.alz.org/getmedia/5d1826c1-1ddd-49ca-badc-44deed8eee40/uspointerbrainhealthrecipe.pdf; Accessed 9th December 2025) on its website consisting of physical exercise, cognitive exercise, health monitoring, and nutrition. According to the Cambridge dictionary, a recipe is “a set of instructions telling you how to prepare and cook food.” This “recipe” framing places responsibility at an individual level (“you”) and is instruction-based, that is, brain healthism. The structured group received “38 facilitated peer team meetings over 2 years, with education, goal-setting, and accountability to support the health behaviors,” whereas the self-guided group received “6 facilitated peer team meetings over 2 years to provide the support” (p. 3, [&lt;span&gt;3&lt;/span&gt;]). So the entire variable of the structured, supported multi-domain intervention (32 extra meetings; exercise in a community center; the MIND diet; supported cognitive and social stimulation; twice-yearly medical advisor appointments) was the randomized factor causally responsible for group differences. It is incorrect to isolate the multi-domain intervention “recipe” as the active component. The POINTER study group differences provide an analogy of social advantage and empirically confirm that more advantaged people (e.g., with more social support) would gain the most from lifestyle-only approaches, worsening pre-existing brain health inequalities [&lt;span&gt;4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Therefore, policy makers and dementia researchers have to choose between brain healthism and a public health approach [&lt;span&gt;4&lt;/s","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 1","pages":"82-83"},"PeriodicalIF":2.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147565970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese Expert Consensus on Immune Checkpoint Inhibitor Therapy for Elderly Patients with Advanced Non-small Cell Lung Cancer (2025 Edition)","authors":"National Center of Gerontology, Lung Cancer Committee of Beijing Oncology Association, Editorial Board of Chinese Journal of Geriatrics,&nbsp;Li Lin,&nbsp;Nie Xin,&nbsp;Wei Qian,&nbsp;Li Xu,&nbsp;Tian Yumeng,&nbsp;Wu Lin,&nbsp;Wang Jingyi,&nbsp;Wang Zhijie,&nbsp;Wang Mingzhao,&nbsp;Cao Baoshan,&nbsp;Gu Yangchun,&nbsp;Huang Meijuan,&nbsp;Yu Min,&nbsp;Yang Bo,&nbsp;Song Qi","doi":"10.1002/agm2.70067","DOIUrl":"https://doi.org/10.1002/agm2.70067","url":null,"abstract":"<p>Immune checkpoint inhibitors (ICIs) are an important treatment option for patients with advanced non-small cell lung cancer (NSCLC). There remains significant uncertainty regarding immunotherapy regimen selection and safety management for elderly lung cancer patients, due to the insufficient inclusion of geriatric patients in current clinical studies and the absence of specific management guidelines or consensus statements for immunotherapy in the elderly population. The consensus integrates the latest evidence-based medical evidence worldwide with clinical practice experience in China. It provides recommendations on key challenges in immunotherapy for elderly patients with advanced NSCLC, including geriatric assessment, treatment regimen selection, management of adverse reactions, and future research directions, aiming to provide a reference for clinical practice.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 1","pages":"5-19"},"PeriodicalIF":2.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147564892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting Medication Adherence in the Elderly: Factors and Insights From a Cross-Sectional Study.","authors":"Shokofeh Afkhami, Farkhondeh Asadi, Hassan Emami, Azam Sabahi","doi":"10.1002/agm2.70053","DOIUrl":"10.1002/agm2.70053","url":null,"abstract":"<p><strong>Objectives: </strong>This study reviewed the factors involved in medication adherence among the elderly. By understanding these factors, we can develop targeted strategies to promote better medication adherence, ultimately improving health outcomes for this population.</p><p><strong>Methods: </strong>This cross-sectional study was performed in 2023. In the first phase, five scientific databases were searched: PubMed, Science Direct, Springer, Wiley, and Wolters Kluwer. The review included articles published between 2001 and January 2022. The keywords used in the searches included \"drug adherence,\" \"medication adherence,\" \"elderly,\" and \"older adults.\" Two researchers independently evaluated the titles, abstracts, and texts of papers. Specific inclusion and exclusion criteria determined the selection of studies. Data were extracted using a data extraction form based on the study objectives. From all 116 articles retrieved, 68 studies were included. In the second phase, factors on medication adherence in the elderly were divided into categories and subcategories.</p><p><strong>Results: </strong>Factors involved in medication adherence among the elderly were divided into two categories: personal and external factors. Personal factors were classified into three subcategories: reducing, increasing, and other, while external factors included cultural, social, and economic factors as well as the influence of others. The most important factor associated with medication non-adherence among the elderly is polypharmacy. Other factors such as economic and social status, cognitive impairment, health literacy, age, and depression also significantly influence medication adherence among the elderly.</p><p><strong>Conclusions: </strong>The health system should focus on managing medications for older adults who use multiple drugs. Providing economic and social support, psychological training, and counseling can ameliorate medication adherence.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 6","pages":"523-555"},"PeriodicalIF":2.5,"publicationDate":"2026-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12793091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Analysis of Serum Uric Acid and Uric Acid Creatinine Ratio With Sarcopenia in the Elderly.","authors":"Yi-Yang Liu, Qi-Fei Kuang, Shuang Li, Qun-Yan Xiang, Yu-Qing Ni, Chen Li, Le Liu, Jing Cai, Yi Wang, Yan-Jiao Wang, You-Shuo Liu","doi":"10.1002/agm2.70055","DOIUrl":"10.1002/agm2.70055","url":null,"abstract":"<p><strong>Objectives: </strong>Sarcopenia is a progressive and systemic skeletal muscle disease. Uric acid is a powerful endogenous antioxidant and an indicator reflecting the nutritional status in the human body. Serum uric acid creatinine ratio (UCR) is serum uric acid (SUA) corrected by renal function. The relationship between SUA, UCR, and sarcopenia remains underexplored. This study explored the correlation between SUA, UCR, and sarcopenia in elderly patients.</p><p><strong>Methods: </strong>This study included 214 elderly patients (aged > 65 years) who were hospitalized in Xiangya Second Hospital from March 2022 to July 2023. <i>T</i> test, <i>U</i> test, or chi-squared test was used to compare the differences between groups. Spearman correlation analysis was used to analyze the correlation between SUA, UCR, and skeletal muscle mass index (SMI) and handgrip strength. The relationship between SUA, UCR, and sarcopenia was estimated by a multivariate logistic regression model. ROC curve was drawn to test the diagnostic efficacy of SUA and UCR for sarcopenia.</p><p><strong>Results: </strong>The levels of SUA and UCR were significantly lower in participants with sarcopenia. Spearman correlation analysis showed that SUA and UCR were positively correlated with handgrip strength and skeletal muscle mass index. Multivariate logistic regression analysis showed that, after adjusting for relevant confounding factors, UCR remained significantly associated with sarcopenia, while SUA didn't. The AUC of SUA combined with UCR in diagnosing sarcopenia in males was 0.744. In females, the progressive significance of SUA was not statistically significant. The AUC of UCR was 0.658.</p><p><strong>Conclusion: </strong>In the elderly, SUA and UCR are related to sarcopenia, but there are certain gender differences.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 6","pages":"556-567"},"PeriodicalIF":2.5,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12793039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Analysis of Lung Cancer With Brain Metastases in Elderly Patients: A Multicenter Retrospective Study.","authors":"Anqi Li, Daqin Feng, Chang Liu, Chaojue Huang, Tang Li, Donggui Wei, Fangyi Wei, Muling Shen, Congzhi Qin, Shufang Deng, Hui Liang, Panlin Mo, Minhai Dong, Yongjia Yu, Lun Liang","doi":"10.1002/agm2.70060","DOIUrl":"10.1002/agm2.70060","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the prognostic factors affecting overall survival (OS) in patients aged ≥ 65 years with lung cancer BMs.</p><p><strong>Methods: </strong>In this multicenter retrospective study, 293 patients aged ≥ 65 years diagnosed with lung cancer BMs between 2010 and 2023 were included. We analyzed the correlation between clinical information, treatment methods, molecular data, and OS. Univariate and multivariate Cox regression models were used to identify risk factors, and Kaplan-Meier survival curves were constructed for analysis.</p><p><strong>Results: </strong>A total of 293 patients aged ≥ 65 years with lung cancer BMs were included (age mean [SD], 69.40 [4.04] years). Univariate analysis of 293 lung cancer patients aged ≥ 65 years with BMs showed that risk prognostic factors included pathological type (SCLC, hazard ratio [HR] = 2.221, 95% confidence interval [CI] = 1.531-3.224, <i>p</i> < 0.001), location of BMs (HR = 1.428, 95% CI = 1.045-1.951, <i>p</i> = 0.025), diagnosis KPS (HR = 0.693, 95% CI = 0.528-0.909, <i>p</i> = 0.008), and targeted therapy (HR = 0.610, 95% CI = 0.465-0.798, <i>p</i> < 0.001). Multivariate analysis showed that pathological type (SCLC, HR = 1.814, 95% CI = 1.230-2.676, <i>p</i> = 0.003), diagnosis KPS (HR = 0.726, 95% CI = 0.550-0.959, <i>p</i> = 0.024), and targeted therapy (HR = 0.008, 95% CI = 0.506-0.902, <i>p</i> = 0.008) were independent factors of OS in such patients.</p><p><strong>Conclusions: </strong>Pathological type, KPS, and targeted therapy significantly impact OS in elderly lung cancer BM patients. Targeted therapy may be a promising option for improving prognosis in this patient population.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier: NCT05609162.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 6","pages":"585-591"},"PeriodicalIF":2.5,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12793065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}