Aging Medicine最新文献

{"title":"Association Between Turn Impairments and Cognitive Function in Parkinson Disease","authors":"Shanhu Xu,&nbsp;Linlin Kong,&nbsp;Xiaoli Liu,&nbsp;Yue Lou,&nbsp;Luyan Gu,&nbsp;Qiuhan Xu,&nbsp;Xun Tan,&nbsp;Jiali Pu,&nbsp;Baorong Zhang","doi":"10.1002/agm2.70033","DOIUrl":"https://doi.org/10.1002/agm2.70033","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the association of turn parameters with cognitive status in patients with Parkinson disease (PD) and determine the value of turn performance in distinguishing PD-related cognitive impairment (CI) from normal cognition (NC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study recruited 168 patients with PD, including 102 patients with NC and 66 patients with CI. The participants performed 180° turn performance trials during the Timed Up and Go walk and 360° turn trials in place using the MATRIX wearable system. Four turn parameters, namely, turn duration, step count, mean turn angular velocity (MAV), and peak turn angular velocity (PAV), were evaluated. Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) were performed to evaluate cognitive function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In comparison with the PD-NC group, the PD-CI group showed significantly higher turn duration and step counts and lower MAV and PAV during both 180° and 360° turns. The four turn parameters were significantly correlated with MMSE and MoCA scores after correction for age and educational level. Regression models suggested that the risk of PD-CI was associated with step counts and MAV during 360° turns. The area under the curve values of the step counts and MAV during 360° turns for distinguishing PD-CI from PD-NC were 0.781 and 0.789, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings indicate that turn performance is associated with cognitive status in patients with PD. Assessment of 360° turn characteristics during routine clinic visits would provide a better understanding of CI status in individuals with PD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 4","pages":"286-293"},"PeriodicalIF":2.5,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spino-Pelvic Alignment and Surgical Outcomes in Chinese Elderly With Lumbar Stenosis Syndrome: A Prospective Study","authors":"Chong Zhao,&nbsp;Linyu Jin,&nbsp;Yan Liang,&nbsp;Haiying Liu,&nbsp;Shuai Xu","doi":"10.1002/agm2.70036","DOIUrl":"https://doi.org/10.1002/agm2.70036","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to systematically identify and quantify the acceptable spino-pelvic parameters for Chinese elderly patients with lumbar stenosis syndrome (LSS) following surgical treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>A prospective study of 165 LSS cases from July 2018 to June 2020 evaluated spino-pelvic alignment using PI, LL, PT, and SVA, categorized by SRS-Schwab classification. Quality of life was assessed via the Oswestry disability index (ODI), and parameter thresholds were determined by AICc and ROC analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No significant change in radiological parameters was observed postsurgery. However, clinical outcomes improved with lower grades of PI-LL and PT. The mean threshold for PI-LL and PT at baseline was 18.8° and 26.1°, respectively. At the endpoint, PI-LL was 17.7°, and PT was 26.1°, indicating optimal ranges for surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Spino-pelvic alignment significantly correlates with quality of life in elderly LSS patients. The study suggests that PI-LL and PT should be maintained within 17.7° and 26.1°, respectively, for optimal surgical outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 4","pages":"347-355"},"PeriodicalIF":2.5,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potentially Inappropriate Medications and Drug–Drug Interactions in Geriatrics Cardiac Patients Visiting to Tertiary Care Central Hospital of Nepal","authors":"Roshan Giri,&nbsp;Rajeev Shrestha,&nbsp;Aatma Rai,&nbsp;Gobinda Kandel,&nbsp;Punam Gauchan,&nbsp;Parbati Thapa","doi":"10.1002/agm2.70034","DOIUrl":"https://doi.org/10.1002/agm2.70034","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Potentially Inappropriate Medications (PIMs) and Drug–Drug Interactions (DDIs) among geriatrics are a prominent issue and place a considerable burden on the quality health outcome. This study aimed to assess PIMs and DDIs particularly among geriatric cardiac elderly patients attending the outpatient department of a tertiary care hospital of Nepal.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methodology</h3>\u0000 \u0000 <p>A prospective cross-sectional study was conducted on geriatrics patients (≥ 65 years) attending the cardiology out-patient department of Bharatpur Central Hospital, Nepal. Beers criteria were used to assess PIM, and Medscape software was employed to assess DDIs. Regression analysis was performed to identify the predictors of PIM and DDIs experienced by patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 140 geriatric patients were enrolled in the study. A total of 683 drugs were prescribed to them, with an average of 4.59 medications per patient. 23.6% and 65% of patients were found to be prescribed PIMs and encountered DDIs, respectively. Proton Pump Inhibitors (PPI) (66.67%) were the most prescribed PIMs and involved in identified DDIs. The removal of PIMs was calculated to reduce 11.72% of the cost of patients prescribed PIMs and 19.88% of identified DDIs. The number of medications prescribed was found to be a significant predictor for PIM (Odd Ratio: 1.352) and DDIs (Odd Ratio: 2.217) encountered.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study highlights the concerning prevalence of potentially inappropriate medication and drug–drug interactions among ambulatory cardiac elderly patients. Integration of regular medication audits and evidence-based prescribing practices is essential to optimize pharmacological management and enhance patient safety.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 4","pages":"303-311"},"PeriodicalIF":2.5,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced Masseter Muscle Area Predicts the 6-Month Outcome After Mild Traumatic Brain Injury in Older Adults","authors":"Liang Wu,&nbsp;Yunfei Li,&nbsp;Meng Sun,&nbsp;Nanyu Yao,&nbsp;Zhaofeng Zhang,&nbsp;Weiming Liu","doi":"10.1002/agm2.70040","DOIUrl":"https://doi.org/10.1002/agm2.70040","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Mild traumatic brain injury (mTBI) in older patients is a common condition in neurosurgery, often linked to poor long-term outcomes, especially when accompanied by frailty. Sarcopenia contributes to this frailty and can be assessed through transverse imaging methods. This study aimed to assess the prognostic value of the masseter muscle cross-sectional area (MCSA) as determined from admission CT head scans in older patients with mTBI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study identified older patients with mTBI who were admitted to our hospital from April 2013 to December 2022. The Glasgow Outcome Scale Extended (GOSE) was utilized to assess neurological outcomes at 6 months follow-up, which were divided into complete recovery (GOSE = 8) and incomplete recovery (GOSE ≤ 7). We measured the average MCSA using admission CT scans and evaluated the consistency of these measurements. Multivariable logistic regression was conducted to evaluate the association between reduced MCSA and 6-month clinical outcomes in older mTBI patients while adjusting for age, gender, and comorbidity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study involved 227 patients, 135 (59.5%) males and 92 (40.5%) females, with a mean age of 74.1 years. 92 (40.5%) had an adverse clinical outcome by the end of follow-up. The intra- and inter-observer reliability of the MCSA measurements was good to excellent (ICCs = 0.955–0.972 and 0.856–0.892). MCSA decreased with age (Pearson's <i>r</i> = −0.290, <i>p</i> &lt; 0.001). Males had higher MCSA than females (<i>p</i> &lt; 0.001). The optimal MCSA cutoff values for predicting 6-month clinical outcomes were 358.75 mm² for male and 263.25 mm² for female patients. Reduced MCSA was associated with 6-month clinical outcomes in univariate and multivariate logistic analyses (OR = 0.131, 95% CI: 0.063–0.273; <i>p</i> &lt; 0.001). The MCSA was linearly associated with incomplete recovery (<i>p</i> &lt; 0.001, P for nonlinear = 0.127).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>MCSA measurements from initial scans were reliable, providing prognostic information that supplemented existing predictors of poor outcomes in older mTBI patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 4","pages":"294-302"},"PeriodicalIF":2.5,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Type 2 Diabetes Mellitus and Chronic Kidney Disease on Bone Mineral Density in Elderly Patients With Fragility Hip Fracture: A Cross-Sectional Study","authors":"Debajyoti Roy,&nbsp;Jiashen Cai,&nbsp;Chee Yong Ng,&nbsp;Sreekanth Koduri,&nbsp;Chang Yin Chionh,&nbsp;Rehena Sultana,&nbsp;Wenxiang Yeon","doi":"10.1002/agm2.70035","DOIUrl":"https://doi.org/10.1002/agm2.70035","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Diabetes mellitus (DM) and chronic kidney disease (CKD) are prevalent conditions in the elderly population, increasing the risk of bone fractures due to their adverse effects on bone quality. This study aimed to assess their impact on bone health and propose interventions to mitigate fracture risk in this demographic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study involving 571 elderly patients (aged ≥ 65 years) with fragility hip fractures was conducted at a tertiary care hospital between June 2014 and June 2016. Patients were categorized into four groups based on DM and CKD presence. Bone mineral density (BMD) at the femoral neck was measured using dual-energy X-ray absorptiometry (DXA) scan. Statistical analysis included ANOVA with Bonferroni correction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean age was 79.5 ± 7.3 years, with females comprising 70.6%. Group 2 (No CKD with diabetes) exhibited higher <i>T</i>-scores than Group 1 (No CKD or Diabetes). Patients with DM had higher <i>T</i>-scores, with an increase of 0.2 compared to those without DM and CKD. Surprisingly, CKD and DM coexistence (Group 4) did not worsen <i>T</i>-scores. Higher HbA1c levels were positively associated with a higher <i>T</i>-score, but this was lost in concurrent CKD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Patients with DM had higher <i>T</i>-scores; the combination of CKD and DM did not worsen <i>T</i>-scores. However, the positive association between higher HbA1c and higher <i>T</i>-score was nullified in concurrent CKD. These findings emphasize the need for tailored interventions to mitigate fracture risk in elderly populations with DM and CKD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 4","pages":"279-285"},"PeriodicalIF":2.5,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tendon Aging: A Silent Enemy Revealed Strategies for Effective Treatment","authors":"Wenhui Gu,&nbsp;Guohua Wang,&nbsp;Haifeng Zhang,&nbsp;Yinxian Yu","doi":"10.1002/agm2.70027","DOIUrl":"https://doi.org/10.1002/agm2.70027","url":null,"abstract":"<p>Tendons have a special makeup and set of physiological characteristics that make it difficult for them to mend themselves after damage. Aged tendons are more prone to injury, and wounded tendons will also age faster than usual. This creates a vicious cycle that might cause an injured tendon to reach surgery standards earlier than necessary or cause a re-injury after surgery. Nowadays, the utilization of appropriate medications and exercise is the mainstay of tendon aging treatment. Due to their high potential for differentiation, tendon stem/progenitor cells (TSPCs) have drawn the attention of an increasing number of studies. The mechanism of tendon aging is outlined in this review, along with how it is caused by oxidative stress, hyperglycemia, inflammation, cell apoptosis, fatty infiltration, and its relationship to TSPCs. The goal of this review was to investigate the mechanism of aging and identify related treatment strategies that can effectively prevent further deterioration, slow down tendon aging, and minimize the risk of tendon re-injury following surgery.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 4","pages":"356-369"},"PeriodicalIF":2.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitude, and Practice on Atrial Fibrillation and Atrial Fibrillation Screening in High-Risk Population: A Cross-Sectional Study","authors":"Zhong Yi,&nbsp;Xinxin Yan,&nbsp;Shaozhi Xi,&nbsp;Lijuan Zhu,&nbsp;Rui Liu,&nbsp;Jing Li,&nbsp;Songwei Ru,&nbsp;Xiu Zheng,&nbsp;Jingxuan Qiu,&nbsp;Chunqi Wang,&nbsp;Na Guo,&nbsp;Yimin Wang,&nbsp;Dayong Gao","doi":"10.1002/agm2.70030","DOIUrl":"https://doi.org/10.1002/agm2.70030","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Atrial fibrillation (AF) is a common clinical arrhythmia. Failure to identify AF leaves patients at a considerably higher risk of disability and death, making its early screening and prevention extremely important. This study aimed to investigate knowledge, attitude, and practice (KAP) towards AF prevention and screening among the high-risk population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Individuals at a high risk of AF were required to fill out questionnaires between August 2022 and October 2022.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 863 participants aged 66.54 ± 11.00 years were enrolled. The median scores of knowledge, attitude, and practice were 9 (81.8% of maximum), 37 (64.9% of maximum), and 21.56 (86.2% of maximum), respectively. Only knowledge (OR = 1.159, 95% confidence interval (CI): 1.045–1.286, <i>p</i> = 0.005) was independently associated with better practice, while attitude (OR = 0.861, 95% CI: 0.817–0.908, <i>p</i> &lt; 0.001), reported poor sleep quality (OR = 0.529, 95% CI: 0.259–1.0788, <i>p</i> = 0.010), fair (OR = 0.234, 95% CI: 0.111–0.491, <i>p</i> &lt; 0.001) or fluctuating (OR = 0.321, 95% CI: 0.103–0.996, <i>p</i> = 0.049) emotional state, and acquiring the questionnaire through social media (OR = 0.419, 95% CI: 0.268–0.653, <i>p</i> &lt; 0.001) were independently associated with worse practice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Participats from high-risk AF population in this study demonstrated acceptable practice towards AF screening, mostly moderated by knowledge and attitude. Some gaps in knowledge could be improved by targeted health education, especially important in vulnerable subpopulations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 4","pages":"312-323"},"PeriodicalIF":2.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Theoretical Hypothesis on Comorbidity in the Elderly—The Disease of Sympathetic Overdrive (DSO)","authors":"Li Jie,&nbsp;Kong Jian,&nbsp;Yu Boxin,&nbsp;Li Hongyang","doi":"10.1002/agm2.70026","DOIUrl":"https://doi.org/10.1002/agm2.70026","url":null,"abstract":"<p>The coexistence of multimorbidity and geriatric syndromes is a big character and role target to manage for the clinic works in older age, but related theories still require innovation and exploration. The disease of sympathetic overdrive (DSO) is a new hypothesis, a disease full of characteristics of organics and emotion, multiple systems, and lifestyle illness. The hypothesis of DSO might be able to explain and improve the theory about the coexistence of multimorbidity and geriatric syndromes and even more!.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 4","pages":"370-374"},"PeriodicalIF":2.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Immersion Technology on the Quality of Life in Older Adults: A Systematic Review","authors":"Solmaz Sohrabei,&nbsp;Vahideh Zolfaghari,&nbsp;Seyed Jafar Ehsanzadeh","doi":"10.1002/agm2.70024","DOIUrl":"https://doi.org/10.1002/agm2.70024","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>In physical reality, mobility limitations often hinder the ability of older individuals to fully interact with the world. Aging increases the likelihood of a decline in social activities. New technologies, including immersion technologies, are increasingly gaining attention as society grapples with the challenges of an aging population. The metaverse offers a compelling opportunity to reimagine the perspective of empowering older individuals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic review was conducted on the PubMed, IEEE, Scopus, and Web of Science databases in December 2024 using a search strategy composed of the keywords “elderly,” “metaverse,” “augmented reality” and “virtual reality,” along with their synonyms in the titles of the articles. Descriptive, qualitative, review, and non-English studies were excluded. The quality assessment of the articles and their bias evaluation were performed based on the JBI index and PRISMA guidelines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The search yielded 1153 articles, 37 of which met the study entry conditions. Thirty studies utilized virtual reality technology for the rehabilitation of elderly people. Most studies aimed to improve symptoms of Alzheimer's disease, physical activity, and cognitive impairment. Seven studies focused on the design and use of immersive technologies to improve Parkinson's symptoms and motor impairments resulting from strokes. Four studies focused on designing environments and games that could help elderly people engage in physical activity and exercise using immersive technologies. The quality of life of elderly people improved in line with the use of these technologies, and symptom weakness improved.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The metaverse can serve as a comprehensive and supportive platform for elderly people. The development of various digital applications or applications covering health, banking, financial affairs, shopping, and social media for performing daily activities from home via an online mode can assist elderly people. The metaverse offers innovative solutions to inspire and support elderly people in staying active. VR and AR technologies provide a dynamic platform for participation in exercise programs, recreational activities, and personalized health programs for elderly people.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 4","pages":"324-346"},"PeriodicalIF":2.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer Burden in Chinese Older Adults: Insights Into Incidence, Mortality, and Global Comparisons Using GLOBOCAN 2022","authors":"Yuanjie Zheng,&nbsp;He Li,&nbsp;Qianru Li,&nbsp;Siyi He,&nbsp;Yi Teng,&nbsp;Mengdi Cao,&nbsp;Nuopei Tan,&nbsp;Jiachen Wang,&nbsp;Tingting Zuo,&nbsp;Tianyi Li,&nbsp;Wanqing Chen","doi":"10.1002/agm2.70028","DOIUrl":"https://doi.org/10.1002/agm2.70028","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To summarize the latest cancer burden among Chinese adults aged 60 years and older and compare it with the global average and four regions classified by Human Development Index (HDI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Cancer incidence and mortality data were extracted from the GLOBOCAN 2022 database. The estimated numbers of new cases and deaths, age-standardized incidence rates (ASIRs), and age-standardized mortality rates (ASMRs) were analyzed for the top ten cancer types in Chinese older adults, categorized by sex and age groups (60–69, 70–84, and 85+ years). Descriptive analyses were conducted to compare ASIRs and ASMRs for all cancer sites combined and major cancer types among adults aged 60 and older across China, the global average, and four HDI-classified regions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In 2022, there were an estimated 2884.2 thousand new cancer cases and 1963.9 thousand cancer deaths among Chinese adults aged 60 and older. The ASIR (1211.8 per 100,000) and ASMR (857.2 per 100,000) for all cancers combined were 1.6 and 2.0 times higher in males than in females, respectively. Nearly half of new cancer cases and deaths occurred in the 70–84 age group, accounting for 48.4% of all cases (1395.9 thousand) and 53.3% of all deaths (1046.4 thousand). Lung, colorectal, stomach, liver, esophageal, prostate, and female breast cancers were the most prevalent cancer types. Compared with the global average and four HDI-classified regions, Chinese older adults had higher ASIRs and ASMRs for lung, stomach, liver, and esophageal cancers but lower rates for prostate and female breast cancers. The ASIR and ASMR for prostate cancer were comparable to those in countries with medium HDI. For female breast cancer, the ASIR was similar to that in countries with low and medium HDI, with a lower ASMR. For colorectal cancer, the ASIR and ASMR were close to the global average but lower than those in countries with very high HDI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Chinese adults aged 60 and older face a heavy burden of lung and digestive cancers, with incidence and mortality patterns reflecting characteristics of both developed and developing regions. Given the rapid population aging and limited healthcare resources, tailored, evidence-based strategies are urgently needed to improve cancer prevention and control in China.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 3","pages":"229-237"},"PeriodicalIF":2.2,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}