Aging Medicine最新文献

{"title":"Trends in age-specific incidence, mortality, and DALYs of female breast cancer from 1990 to 2021","authors":"Subhadra Priyadarshini,&nbsp;Kunja Bihari Panda","doi":"10.1002/agm2.12382","DOIUrl":"10.1002/agm2.12382","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Breast cancer is a leading cause of morbidity and mortality among women worldwide. This study aims to analyze the trends in breast cancer incidence, mortality, and disability-adjusted life years (DALYs) across different age groups from 1990 to 2021, and to project the mortality rate for the next decade.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Global breast cancer data were analyzed, focusing on three distinct age groups: 15–49 years, 50–69 years, and 70+ years. Joinpoint regression analysis was used to identify periods of significant changes in cancer rate trends (joinpoints). Age-specific annual percent changes (APC) and average annual percent changes (AAPC) were calculated to identify trends over time. Additionally, an autoregressive integrated moving average (ARIMA) model was employed to forecast future mortality rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The overall incidence of breast cancer increased significantly with an AAPC of 1.6% from 1990 to 2021. The highest increase was observed in the 15–49 years age group (AAPC: 1.3%), while the 70+ years age group showed the lowest increase (AAPC: 0.2%). Mortality rates exhibited a complex pattern, with a modest overall increase (AAPC: 0.8%), a slight increase in the 15–49 years age group (AAPC: 0.4%), and decreases in both 50 and 69 years (AAPC: −0.4%) and 70+ years age groups (AAPC: –0.3%). DALY rates increased slightly overall (AAPC: 0.7%), primarily driven by the 15–49 years age group (AAPC: 0.4%), while the older age groups showed a declining trend (AAPC: −0.4%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Incidence rates are rising across all age groups, with the highest increase observed among younger women (15–49 years). In contrast, older age groups (50 + years) are experiencing improvements in mortality and DALYs. These findings underscore the need for targeted public health interventions, enhanced screening practices, and ongoing advancements in breast cancer treatment to address the evolving burden of this disease across different age groups.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"770-780"},"PeriodicalIF":2.2,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive accuracy of comorbidity index models in assessing mortality risk among hemodialysis patients: A comprehensive single-center observational cohort study","authors":"Yanna Yu,&nbsp;Fen Li,&nbsp;Zhan Wang,&nbsp;Zhibin Ni,&nbsp;Shu Zhang,&nbsp;Weihong Zhao,&nbsp;Xiaohua Pei","doi":"10.1002/agm2.12384","DOIUrl":"10.1002/agm2.12384","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Comorbidity prediction models have been demonstrated to offer more comprehensive and accurate predictions of death risk compared to single indices. However, their application in China has been limited, particularly among maintenance hemodialysis (MHD) patients. Therefore, the objective of this study was to evaluate the utility of comorbidity index models in predicting mortality risk among Chinese MHD patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methodology</h3>\u0000 \u0000 <p>The MHD patients in the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine were taken as the subjects. Claims-based disease-specific refinements matching translation to ICD-10 and flexibility (CDMF-CCI) model and Liu model were selected as the candidate models for this verification research. Univariate and multivariate Cox regression calculations were used to analyze the independent predictive effect of the models on survival rate.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Annually, nearly 500 patients undergo hemodialysis treatment. From January 2019 to June 2022, a total of 199 patients succumbed, with a mean age of 65.2 years. During these 4 years, the mortality rates were 13.04%, 9.68%, 11.69%, and 6.39%, respectively. The leading causes of death were sudden demise (82 patients, 41.2%), cardiovascular disease (48 patients, 24.1%), pulmonary infection (33 patients, 16.5%), and stroke (19 patients, 9.5%). When compared to individual indices, the CDMF-CCI model displayed more accurate and predictive results, with an HR of 1.190 (<i>P</i> = 0.037). Conversely, the Liu model failed to identify high-risk individuals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The MHD patients face a significant risk of mortality. When compared to univariate parameters and the Liu model, the CDMF-CCI model exhibits superior predictive accuracy for mortality in MHD patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"737-743"},"PeriodicalIF":2.2,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Denture use and a slower rate of cognitive decline among older adults with partial tooth loss in China: A 10-year prospective cohort study","authors":"Xiang Qi,&nbsp;Zheng Zhu,&nbsp;Yaolin Pei,&nbsp;Bei Wu","doi":"10.1002/agm2.12383","DOIUrl":"10.1002/agm2.12383","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Denture use has been shown to improve nutritional intake and diet quality in people with tooth loss. Despite evidence linking tooth loss and dementia, few studies have examined the association between denture use and cognitive decline. We investigated the relationship between denture use and cognitive decline among Chinese older adults with tooth loss.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed data from the Chinese Longitudinal Healthy Longevity Survey 2008–2018, including 27,708 community-dwelling dentate and edentulous (i.e., who have lost all natural teeth) older adults aged 65 and older. Cognitive function was assessed using the Mini-Mental State Examination from 2008 to 2018. Linear mixed-effect models were employed to assess the association of denture use with baseline cognitive function and rate of cognitive decline, adjusting for sociodemographic characteristics, health-related behavior, and health status. Subgroup analyses evaluated differences in associations among dentate participants with varying degrees of tooth loss (1–9, 10–19, 20–31).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared to non-denture users, dentate participants who used dentures had better baseline cognitive function (<i>β</i>, 1.032; 95% CI, 0.813–1.251; <i>p</i> &lt; 0.001) and a slower annual decline in cognitive function (<i>β</i>, 0.127; 95% CI, 0.047–0.206; <i>p</i> &lt; 0.01). For edentulous participants, denture use was associated with higher baseline cognitive function (<i>β</i>, 3.063; 95% CI, 2.703–3.423; <i>p</i> &lt; 0.001) but not with the rate of cognitive decline (<i>β</i>, 0.011; 95% CI, –0.082 to 0.105; <i>p</i> = 0.818). Results remained consistent across subgroups of dentate participants with various degrees of missing teeth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Denture use may help protect against cognitive decline in older adults with partial tooth loss. This study highlights the potential importance of prosthodontic rehabilitation in preserving cognitive health. Further research is needed to establish a causal relationship between denture use and cognitive function.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"781-789"},"PeriodicalIF":2.2,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound blood–brain barrier opening: A new era of treatment for Alzheimer's disease?","authors":"Cuiping Wang,&nbsp;Junhong Ren","doi":"10.1002/agm2.12371","DOIUrl":"10.1002/agm2.12371","url":null,"abstract":"&lt;p&gt;The blood–brain barrier (BBB) plays an important role in maintaining the stability of the central nervous system (CNS). However, it serves as a formidable barrier that restricts the entry of therapeutic agents. Recent research shows that some pathways have the potential to reshape conventional drug delivery paradigms and address the limitations caused by the selectivity of the BBB. Innovative approaches to enhance drug delivery include intranasal delivery exploiting olfactory and trigeminal pathways, as well as techniques such as temporary BBB opening using chemicals and receptors, or focused ultrasound (FUS).&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; These technologies have their pros and cons. The intranasal delivery route is considered non-invasive, and drug transportation might proceed via the olfactory and trigeminal pathways, ultimately leading access to the CNS.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; However, nasal administration exhibits certain limitations, such as the lack of consistency in the administered dosage of the drug.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; Chemicals, such as borneol and alkyl glycerols, can enhance the permeability of the BBB, potentially revolutionizing drug delivery to the brain. However, consideration must be given to their potential toxicity and lack of selectivity. The second approach involves modifying tight junctions using adenosine receptor agonists, which has various advantages for drug administration across the BBB. Receptor-mediated modulation, owing to its inherent reversibility, has advantages of temporal regulation and adaptability during pharmaceutical administration.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; The limitations of receptor-mediated tight junction transition include the absence of suitable receptors within the targeted region, the potential for unintended consequences for unrelated biological pathways or tissues, the inherent variability in receptor expression across the BBB, and the requirement for meticulous adherence to regulatory and safety protocols.&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt; The third approach involves FUS to facilitate drug transport through the BBB. The application of FUS spans various domains, encompassing imaging, tumor ablation, neuromodulation, targeted gene therapy, and increasing drug delivery to the cerebral region.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; Magnetic resonance imaging (MRI) guided FUS uses focused ultrasound energy, delivered transcranially, to treat a variety of neurological diseases, such as essential tremor (ET), Parkinson disease (PD), neuropathic pain, and dystonia.&lt;span&gt;&lt;sup&gt;6, 7&lt;/sup&gt;&lt;/span&gt; A variety of neuropathic pain syndromes have been successfully treated using MRI-guided FUS central lateral thalamotomy.&lt;span&gt;&lt;sup&gt;6&lt;/sup&gt;&lt;/span&gt; MRI-guided FUS ventralis intermedius (VIM) thalamotomy is now a well-established and federal drug administration (FDA) approved therapy in medication-refractory ET and for the motor symptoms of PD. The use of concurrent MRI allows highly accurate spatial and thermal guidance, with fine anato","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"673-675"},"PeriodicalIF":2.2,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive, preventive and personalized project of vascular cognitive impairment in China (P3): Study design and interim baseline patient characteristics of a Nationwide multicenter prospective registry","authors":"Linlin Wang,&nbsp;Jiwei Jiang,&nbsp;Yanli Wang,&nbsp;Gaifen Liu,&nbsp;Wenyi Li,&nbsp;Qiwei Ren,&nbsp;Shirui Jiang,&nbsp;Min Zhao,&nbsp;Huiying Zhang,&nbsp;Tianlin Jiang,&nbsp;Shiyi Yang,&nbsp;Mei Cui,&nbsp;Qiang Dong,&nbsp;Jun Xu","doi":"10.1002/agm2.12377","DOIUrl":"10.1002/agm2.12377","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To outline the design of the P3 study and serve as a summary of the interim baseline patient characteristics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>P3 study is a multicenter, prospective cohort study targeting 1000 acute ischemic stroke (AIS) and cerebral small vessel disease (CSVD) patients with a 2-year follow-up from 80 participating hospitals across China. Comprehensive multimodal imaging, neuropsychological tests, and biological samples were collected prospectively on admission and follow-up visits. Patients were interviewed face to face for 2 years and followed up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Until 30 December 2023, 642 patients were enrolled from 67 centers. In the AIS cohort, 219 patients (72.5%) were diagnosed with acute post-stroke cognitive impairment (PSCI). Compared to those without PSCI, the acute PSCI group exhibited significantly lower levels of education and a history of stroke (all <i>P</i> &lt; 0.05). In the CSVD cohort, 53 patients (41.4%) were diagnosed with cognitive impairment. Compared to those with normal cognitive function, the impaired cognitive function group had a significantly higher prevalence of hypertension and diabetes history (all <i>P</i> &lt; 0.05). All 642 patients completed 20 tests, as well as clinical information and blood sample collection. Nearly 95% of the patients underwent structural MRI and ASL, and 60% of patients completed fMRI and DKI or DTI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>P3 study aims to establish a comprehensive spatiotemporal profile of VCI. Through multidimensional analysis of clinical information, radiomics, proteomics, metabolomics, microbiomics, and genetics, provide a more comprehensive understanding of VCI trajectories and individual variability, enhancing early detection and prognosis management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"744-753"},"PeriodicalIF":2.2,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel hormonal agents in men with metastatic castration resistant prostate cancer and reduced performance status: Experiences of a specialized single center","authors":"Thomas Büttner,&nbsp;Philipp Lossin,&nbsp;Stefan Latz,&nbsp;Carolin Jacobs,&nbsp;Philipp Krausewitz,&nbsp;Stefan Hauser","doi":"10.1002/agm2.12372","DOIUrl":"10.1002/agm2.12372","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Attaining castration resistance in metastatic prostate cancer (mCRPC) represents a pivotal juncture in the progression of the patient's illness and treatment regimen. Within this therapeutic context, novel hormonal agents (NHA) constitute a fundamental component of pharmacological intervention. However, the efficacy of NHA therapy remains uncertain for patients with a compromised general condition, as indicated by an Eastern Cooperative Oncology Group Performance Status (ECOG PS) score of ≥2. Notably, most clinical trials excluded individuals with an ECOG PS ≥2, leaving a gap in our understanding of the potential benefits of NHA therapy for this specific patient cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted an analysis of fifty-three NHA-naïve men characterized by attaining mCRPC at an ECOG PS of ≥2 subsequent to androgen deprivation monotherapy between 2008 and 2023. Patients were then treated with either NHA or Best Supportive Care (BSC) based on individual decisions. Survival and adverse event (AE) analysis was performed to assess the outcomes of NHA therapy compared to BSC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the patients, 30 (56.6%) received NHA, whereas the remaining 23 (43.4%) choose BSC. No significant differences in baseline characteristics were observed between the NHA and BSC group. Median overall survival (OS) was 9.1 months in the BSC group and 7.0 months in the NHA group, with no significant OS benefits associated with NHA treatment. AEs and severe AEs commonly occurred, but remained indifferent between treatment groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings suggest that NHA therapy may confer reduced survival benefits in mCRPC patients with ECOG PS ≥2. While hope for NHA treatment persists, particularly given its oral administration and tolerability, careful consideration and discussion with patients regarding treatment expectations and palliative care goals are warranted in this challenging patient population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"761-769"},"PeriodicalIF":2.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with hypercholesterolemia in older adults: A cross-sectional investigation","authors":"Maria Clara Alves de Oliveira,&nbsp;Júlia Perfeito Andrade,&nbsp;Ana Carolina Souza Porto,&nbsp;Gizelly Maria Torres Martins,&nbsp;Nurielly Monteiro Campos,&nbsp;Paulo da Fonseca Valença Neto,&nbsp;Claudio Bispo De Almeida,&nbsp;Saulo Sacramento Meira,&nbsp;Beatriz Cardoso Roriz,&nbsp;Débora Jesus da Silva,&nbsp;Victor Giovannino Accetta,&nbsp;Cezar Augusto Casotti,&nbsp;Lucas dos Santos","doi":"10.1002/agm2.12373","DOIUrl":"10.1002/agm2.12373","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the factors associated with hypercholesterolemia in older adults residing in a small municipality in northeastern Brazil.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a population-based cross-sectional epidemiological study conducted with 232 older adults (women: 58.60%; men: 41.40%) in Aiquara, Bahia, Brazil. Independent variables included socioeconomic, behavioral, and health-related factors. The outcome was self-reported hypercholesterolemia (yes or no). Poisson regression with a robust estimator was used to calculate Prevalence Ratios (PR) and their respective 95% Confidence Intervals (CI) in the inferential analysis. Gross models were initially developed, followed by a hierarchical multiple explanatory model (Level 1: socioeconomic variables; Level 2: behavioral aspects; Level 3: health conditions).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The observed prevalence of hypercholesterolemia was 34.50% (men: 21.90%; women: 43.40%). Additionally, a higher probability of hypercholesterolemia was observed in women (PR: 1.94; 95% CI: 1.27–2.97); participants with high sedentary behavior (PR: 1.47; 95% CI: 1.03–2.09); those with abdominal obesity (PR: 1.65; 95% CI: 1.06–2.57); and those with diabetes mellitus (PR: 1.54; 95% CI: 1.04–2.29).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The main results showed that female sex, high sedentary behavior, abdominal obesity, and diabetes mellitus were positively associated with hypercholesterolemia in the older population of the study.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"727-736"},"PeriodicalIF":2.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triglyceride-glucose index trajectories predict adverse cardiovascular outcomes in elderly heart failure patients with Diabetes: A retrospective cohort study","authors":"Hong Liu,&nbsp;Jian Wang,&nbsp;Zhi Luo,&nbsp;Ding Jia,&nbsp;Shixing Feng,&nbsp;Zhufang Yang,&nbsp;Zeyu Wang","doi":"10.1002/agm2.12374","DOIUrl":"10.1002/agm2.12374","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Evaluating the change trajectories of triglyceride-glucose (TyG) index calculated after multiple tests in elderly heart failure (HF) patients may have clinical implications for predicting long-term adverse cardiovascular events (MACEs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included 1184 elderly HF (LVEF ≥50%) patients with diabetes admitted to our center between January 2015 and January 2020. Based on the multiple TyG levels detected during the exposure period with annual measurements, three distinct TyG trajectories were determined using latent mixture modeling: low-stable group (TyG index &lt;8.26, <i>n</i> = 367), medium-stable group (TyG index 8.26–9.06, <i>n</i> = 613), and high-increasing group (TyG index &gt;9.06, <i>n</i> = 204). The primary endpoint was the composite outcome of MACEs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were significant increases in the prevalence of several cardiovascular risk factors and conditions, such as male gender, BMI, current smoker, hyperlipidemia, atrial fibrillation, old myocardial infarction, fasting glucose, triglycerides, and uric acid levels, from the Low-Stable Group to the High-Increasing Group (all <i>P</i> &lt; 0.05). During a median follow-up of 29 months (range, 18–46 months), 181 MACEs occurred. Kaplan–Meier analyses curve showed a significantly increased risk of MACEs in the medium-stable and high-increasing groups compared to the low-stable group (<i>HR</i> = 2.528, 95%<i>CI</i>: 1.665–3.838; <i>HR</i> = 2.706, 95%<i>CI</i>: 1.722–4.255, respectively). Furthermore, the rates of heart failure-related hospitalizations, nonfatal myocardial infarctions and non-fatal stroke were significantly increased in the medium-stable and high-increasing groups. Multivariable Cox regression analyses revealed that age (<i>HR</i> = 1.728), current smoker (<i>HR</i> = 1.385), old myocardial infarction (<i>HR</i> = 1.593), chronic renal disease (<i>HR</i> = 1.682), HbA1c (<i>HR</i> = 1.816), NT-proBNP (<i>HR</i> = 2.471), TyG trajectory (<i>HR</i> = 2.112) and SGLT2 inhibitors (<i>HR</i> = 0.841) were independently associated with the occurrence of MACEs during follow-up (<i>P</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The TyG trajectory is strongly associated with the risk of MACEs during follow-up in elderly patients with T2DM, suggesting that TyG trajectories may further optimize risk stratification model of cardiovascular events.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"717-726"},"PeriodicalIF":2.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of arthritis with functional disability and depressive symptoms in general US adults: NHANES 1988–1994 and 1999–2018","authors":"Xiaoting Liu,&nbsp;Yunzhen Huang,&nbsp;Jinjing Fu,&nbsp;Mayila Mohedaner,&nbsp; Danzengzhuoga,&nbsp;Gan Yang,&nbsp;Zhenqing Yang,&nbsp;Xueqin Li,&nbsp;Xinye Ma,&nbsp;Qiqi Zhang,&nbsp;Zuyun Liu,&nbsp;Xifeng Wu,&nbsp;Zhimin Ying","doi":"10.1002/agm2.12379","DOIUrl":"10.1002/agm2.12379","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to examine the associations of arthritis with functional disability and depressive symptoms among general US adults. Additionally, it explored the relationship between radiographic knee osteoarthritis (assessed by X-ray examination) and functional disability. Above findings seek to highlight the need for comprehensive physical and mental health management in individuals with arthritis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We designed a cross-sectional study utilizing multivariable logistic regression models to examine the associations. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were documented in a crude model and three adjusted models. Participants were from the National Health and Nutrition Examination Survey (NHANES) 1988–1994 and 1999–2018. Arthritis was self-reported or graded by the Kellgren–Lawrence score after an objective X-ray examination. Functional disability included disability in activities of daily living (ADL disability), instrumental activities of daily living (IADL disability), and mobility disability. Depressive symptom was assessed using the Patient Health Questionnaire (PHQ).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We included 22,566 older adults (≥60 years; 10,961 had self-reported arthritis) for functional disability analysis (2377 older adults with data on X-ray examination; 1012 had radiographic knee osteoarthritis) and 32,056 adults (≥20 years; 9175 had self-reported arthritis) for depressive symptom analysis. After controlling for all covariates, self-reported arthritis was associated with ADL disability (odds ratios [OR]: 2.677; 95% confidence interval [CI]: 2.499–2.868), IADL disability (OR: 2.064; 95% CI: 1.940–2.196), and mobility disability (OR: 2.954; 95% CI: 2.778–3.142), and depressive symptom (OR: 2.177; 95% CI: 1.979–2.395). In participants with data on X-ray examination, radiographic knee osteoarthritis was only associated with mobility disability (OR: 1.437; 95% CI: 1.183–1.744).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Self-reported arthritis was associated with ADL disability, IADL disability and mobility disability, and depressive symptoms. Among participants with X-ray data, radiographic knee osteoarthritis was only associated with mobility disability in general US adults. Appropriate managements of both physical and mental health are needed for individuals with arthritis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"705-716"},"PeriodicalIF":2.2,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family support and dementia screening participation among older adults: Evidence from a South Korea fact-finding survey on the status of older adults","authors":"Jieun Kim,&nbsp;Hooyeon Lee","doi":"10.1002/agm2.12380","DOIUrl":"10.1002/agm2.12380","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>South Korea is one of the most rapidly aging societies worldwide and the prevalence of dementia is expected to rise to 10.3% by 2025. Early diagnosis requires early access to support, information, and medication. Dementia screening is important for the success of dementia-related healthcare programs. We investigated the rate of participation in dementia screening and the relationship with family support.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used data from the 2020 “South Korea fact-finding survey on status of older adults,” a cross-sectional survey targeting adults aged ≥65 years. A total of 9558 respondents were analyzed. We used multivariable logistic regression to analyze the associations between sociodemographic characteristics, including family support, and dementia screening participation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 62.2% participants received emotional support from their family, and 20.6% received physical support with cleaning, meal preparation, and laundry, general care, nursing, and traveling to the hospital. Of the respondents, 41.8% had participated in dementia screening during the previous 2 years. Older adults with emotional support (OR = 1.41, 95% CI, 1.28–1.54) and physical support (OR = 1.46, 95% CI, 1.31–1.62) were more likely to undergo dementia screening than those without such support. Age, annual household income, education, reason for working, drinking status, exercise, emotional support, and physical support were significantly associated with dementia screening in older adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Older adults with low emotional or physical support from family should be considered a vulnerable population with respect to non-participation in dementia screening. Therefore, policies targeting these high-risk groups are needed to increase the dementia screening rate.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"754-760"},"PeriodicalIF":2.2,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}