Aging Medicine最新文献

{"title":"Synthetic MRI Neuroimaging Correlates of Frailty: Correlations Between Frailty Scales and Brain Structural Integrity","authors":"Yuhui Chen, Fan Feng, Sicong Wang, Qi Wang, Hua Wang, Min Chen, Tao Gong, Chunmei Li","doi":"10.1002/agm2.70084","DOIUrl":"10.1002/agm2.70084","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Frailty, a common condition in the elderly, is characterized by a decline in physiological reserves and an increased vulnerability to stressors, leading to negative health outcomes such as falls, fractures, and prolonged recovery from illness. Despite its clinical significance, the relationship between frailty and cerebral health, particularly the correlation of frailty evaluation scales with brain structural integrity changes, is not well-defined. The study aims to investigate the associations between frailty and brain structure, focusing on the relationship between various frailty scales and brain volumetric and relaxometric changes as identified by synthetic MRI neuroimaging techniques.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective study initially enrolled 109 participants from the neurology ward. After applying exclusion criteria, 41 participants were included in the final analysis. Data on demographics, medical history, and physical examinations were collected. Synthetic MRI was conducted using a MAGnetic resonance image Compilation (MAGiC) with images processed using SyMRI 8.0 and SPM12 software for volumetric and relaxometric analyses. Frailty was assessed using the Clinical Frailty Scale (CFS), Fried scale, FRAIL scale, and Edmonton Frailty Scale (EFS). Statistical analysis was performed by partial correlation analysis, adjusting for age, gender, and history of stroke, to examine the relationships between global and regional brain volumetric and relaxometry parameters with frailty scales. To control for multiple comparisons, the false discovery rate (FDR) method was applied, with statistical significance set at FDR-adjusted <i>p</i> value < 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared to non-frail participants, frail individuals exhibited significantly lower gray matter volumes in the cerebellum, hippocampus, and thalamus, as well as reduced white matter volumes globally and in the temporal and parietal lobes. Brain relaxometry revealed higher hippocampal and thalamic T1 and T2 values in the frail group. The CFS and EFS were significantly correlated with global and regional gray and white matter volumes, indicating a link between frailty severity and brain structural integrity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study highlights significant correlations between frailty scales, particularly CFS and EFS, and changes in brain volumetry and relaxometry in specific brain regions. These findings suggest that the CFS and EFS may serve as sensitive frail","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 3","pages":"278-290"},"PeriodicalIF":3.1,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Early Postoperative Blood Pressure Variability and Hypertension Status on 90-Day Functional Outcomes in Acute Ischemic Stroke due to Large Vessel Occlusion Patients Treated With Mechanical Thrombectomy","authors":"Yunpeng Liu,&nbsp;Yiqi Liu,&nbsp;Zeping Jin,&nbsp;Jumei Huang,&nbsp;Yang Wang","doi":"10.1002/agm2.70095","DOIUrl":"10.1002/agm2.70095","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To investigate the impact of early postoperative blood pressure variability (BPV) on 90-day functional outcomes in patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO) undergoing mechanical thrombectomy, and to assess its interaction with pre-existing hypertension.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study included 144 AIS-LVO patients treated with mechanical thrombectomy between January 2022 and September 2024. Systolic blood pressure was recorded hourly during the first 24 h post-procedure, and BPV was calculated as the standard deviation of systolic BP. Patients were divided into low and high BPV groups according to the median BPV value. Functional outcome at 90 days was assessed using the modified Rankin Scale (mRS), with 0–2 defined as favorable. Subgroup analyses were performed according to hypertension status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients in the high BPV group had significantly higher baseline NIHSS and worse 90-day mRS scores (<i>p</i> = 0.021 and <i>p</i> = 0.007, respectively). Favorable outcomes were achieved in 29.5% of high BPV patients compared with 60% of low BPV patients (<i>p</i> = 0.007). ROC analysis showed moderate predictive ability of BPV for favorable outcomes (<i>AUC</i> = 0.743, <i>95% CI</i>: 0.662–0.840). The detrimental effect of elevated BPV was more pronounced among patients with pre-existing hypertension.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Elevated early postoperative BPV is independently associated with worse 90-day functional outcomes in AIS-LVO patients undergoing thrombectomy, particularly in those with hypertension. These findings suggest that maintaining stable blood pressure during the early postoperative period may help optimize recovery in this high-risk population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 3","pages":"309-315"},"PeriodicalIF":3.1,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Patient Health Questionnaire-2 (PHQ-2) in Detecting Depression Among Older Adults","authors":"Francesco Salis,&nbsp;Maristella Belfiori,&nbsp;Alessandro Ferrau,&nbsp;Eleonora Bernardini,&nbsp;Emanuele Concas,&nbsp;Anna Maria Lugas,&nbsp;Antonella Mandas","doi":"10.1002/agm2.70089","DOIUrl":"10.1002/agm2.70089","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Depression screening tools like the Patient Health Questionnaire-2 (PHQ-2) are commonly used to detect depression. However, its performance in elderly populations has been less extensively studied compared to its broader adult use. This study evaluates the PHQ-2's ability to screen for depression in older adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study was conducted by enrolling 320 elderly individuals (≥ 65 years) from a geriatric outpatient service from May 2023 to July 2024. The sample was randomly split into a validation group and a test group. The discriminatory power of PHQ-2 was evaluated by comparing it to the Geriatric Depression Scale (GDS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The PHQ-2 demonstrated good discriminatory ability, with a Receiver Operating Characteristic Area Under the Curve (AUC) of 0.802 (95% CI: 0.703–0.901) in the validation group. The optimal cutoff for the PHQ-2 was 3 points, yielding a sensitivity of 71% and accuracy of 78%. The model showed high specificity (80%) and negative predictive value (93%), suggesting that few depressed individuals would go undetected. These findings were consistent in the test group (AUC: 0.789).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The PHQ-2 is a reliable and efficient tool for screening depression in older adults, with strong diagnostic performance and ease of use. This study supports its application in primary care settings, facilitating timely referrals for further evaluation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 3","pages":"244-249"},"PeriodicalIF":3.1,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morbidity Among the Aging Population in Northern Bangladesh: An Epidemiological Study","authors":"Md. Abu Sayem,&nbsp;Md. Golam Hossain,&nbsp;Md. Mothashin,&nbsp;Md. Nurul Islam","doi":"10.1002/agm2.70092","DOIUrl":"10.1002/agm2.70092","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Morbidity is a prevalent public health issue especially among the aging population worldwide. As the risks of morbidity increase with age, aging populations increasingly become a socioeconomic burden on their families. However, studies on morbidity among aging populations in Bangladesh remain limited and under-documented. This study aims to determine the prevalence of morbidity and identify the associated factors among aging populations in Northern Bangladesh.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The cross-sectional study was conducted in the northern part of Bangladesh. Data were collected from 540 aging people; they were selected using multistage random sampling. Face-to-face interviews were conducted by 12 trained interviewers for collecting data, and it was done from June 5, 2022 to August 18, 2022. The outcome variable morbidity was measured by a question, “are you suffering from chronic diseases?” Based on the answer, the respondents were classified into three classes; (i) did not have any disease (0 = No), (ii) having only one disease (1 = single), and (iii) having more than one disease (2 = morbidity). Finally, (iii) was considered as morbidity (Yes, code 1), and (i) and (ii) together were considered did not have morbidity (No, code 0). According to the objectives of the study, we used descriptive statistics, the &lt;i&gt;χ&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; test, and multivariate logistic regression to determine the prevalence and to assess the factors influencing morbidity respectively.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The study revealed that the prevalence of morbidity was found 75.74% [95% CI: 0.719–0.793] among people. The significantly associated factors of morbidity included being male [AOR = 1.717; 95% CI = 1.109–2.657; &lt;i&gt;p&lt;/i&gt; = 0.015], living in a rural area [AOR = 1.758; 95% CI = 1.082–2.856; &lt;i&gt;p&lt;/i&gt; = 0.023], age above 70 [AOR = 1.926; 95% CI = 1.178–3.150; &lt;i&gt;p&lt;/i&gt; = 0.009], having prior disability [AOR = 1.932; 95% CI = 1.126–3.315; &lt;i&gt;p&lt;/i&gt; = 0.017], being underweight [AOR = 4.045; 95% CI = 1.568–10.438; &lt;i&gt;p&lt;/i&gt; = 0.004], and overweight [AOR = 1.957; 95% CI = 1.223–3.132; &lt;i&gt;p&lt;/i&gt; = 0.005].&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Morbidity is highly prevalent among aging populations, with over nourished individuals aged 70 and above, particularly those living in rural areas, being the most significantly affected. Targeted interventions should focus on improving nutritional status and raising awareness, particularly in rural areas, to help reduce the burden of morbidity among ag","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 3","pages":"236-243"},"PeriodicalIF":3.1,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers of Sarcopenia: Current Status and Future Perspectives","authors":"Bijin Luo,&nbsp;Wenhan Li,&nbsp;Yi Zhang,&nbsp;Mengchen Liu,&nbsp;Kemeng Zhang,&nbsp;Sui Huang,&nbsp;Ping He","doi":"10.1002/agm2.70088","DOIUrl":"10.1002/agm2.70088","url":null,"abstract":"<p>Sarcopenia is an age-related skeletal muscle disorder characterized by progressive declines in muscle mass, strength, and physical function, which profoundly impair quality of life in older adults. Although current clinical guidelines propose various diagnostic approaches and cutoff values, considerable heterogeneity among criteria and assessment tools continues to pose challenges for the accurate and early diagnosis of sarcopenia. In recent years, an increasing number of studies have identified potential biomarkers associated with sarcopenia, which can be broadly classified into biochemical, imaging-based, and physical performance–related categories. The identification of these biomarkers has improved diagnostic accuracy, provided additional means for monitoring disease progression, and opened new avenues for therapeutic intervention. This narrative review aims to summarize currently established and emerging biomarkers related to sarcopenia, with a particular focus on their biological relevance, clinical applicability, and limitations. Furthermore, potential directions for future research are discussed to facilitate the development of integrated, multimodal biomarker strategies for the early detection, risk stratification, and personalized management of sarcopenia.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 3","pages":"325-337"},"PeriodicalIF":3.1,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the Protective Effects of Long-Term Physical Activity, Exercise, Mental Health, and Employment on Sarcopenia—A Result of a Feasibility Study of a Registry","authors":"Mohammad Reza Shadmand Foumani Moghadam,&nbsp;Mostafa Shahraki Jazinaki,&nbsp;Sharif Etemadi,&nbsp;Kazem Eslami,&nbsp;Pegah Meghdadi,&nbsp;Parnian Pezeshki,&nbsp;Mohammad Amoushahi,&nbsp;Reyhane Bakhshipour,&nbsp;Majid Ghayour Mobarhan,&nbsp;Majid Khadem-Rezaiyan,&nbsp;Reza Rezvani,&nbsp;Zohre Hosseini","doi":"10.1002/agm2.70087","DOIUrl":"10.1002/agm2.70087","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Sarcopenia, an age-related muscle disease, is influenced by a variety of factors, making it essential to explore the associations of physical activity, psychological health, employment, and exercise with this condition in a healthy, well-nourished population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>This study was conducted with 766 healthy adults to assess these relationships based on EWGSOP2. Participants completed the IPAQ and provided a work and exercise history. Mental health was evaluated using BDI-13 and DASS-21.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Result</h3>\u0000 \u0000 <p>Physical activity, both current and past, was significanly associated with a lower odds of sarcopenia. Employment status and type of work were also associated with odds of sarcopenia. Participation in sports and exercise duration were linked to decreased odds (OR = 0.687 (95% CI = 0.600–0.787), <i>p</i> &lt; 0.005), with specific activities like swimming and certain traditional Iranian sports showing strong associations. Psychological factors such as scores of depression (OR = 1.149 (95% CI = 1.112–1.189), <i>p</i> &lt; 0.005), anxiety (OR = 1.233 (95% CI = 1.176–1.293), <i>p</i> &lt; 0.005), and stress (OR = 1.084 (95% CI = 1.056–1.114), <i>p</i> &lt; 0.005) were associated with an increased odds of sarcopenia. The multivariable analyses confirmed the independent relationships of physical activity and some mental health components with sarcopenia. Predictive models highlighted the importance of physical activity, exercise, and employment status as key variables associated with sarcopenia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study revealed that higher work engagement, better mental health components (including lower stress, depression, and anxiety), higher levels of physical activity and, longer duration of exercise, and engaging in specific types of exercise may be related to lower odds of sarcopenia.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 3","pages":"265-277"},"PeriodicalIF":3.1,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymph Node Metastasis Pattern and Influencing Factors in Esophageal Squamous Cell Carcinoma","authors":"Yuheng Wang,&nbsp;Qingqing Ding,&nbsp;Lei Xue,&nbsp;Jinhua Luo","doi":"10.1002/agm2.70096","DOIUrl":"10.1002/agm2.70096","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To investigate the lymph node metastasis (LNM) pattern of esophageal squamous cell carcinoma (ESCC) and identify factors associated with LNM:</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective study was conducted including 388 patients with ESCC who underwent curative resection at the First Affiliated Hospital of Nanjing Medical University between January 2020 and December 2022. Clinicopathological characteristics and lymph node metastasis patterns were analyzed. Univariate and multivariate analyses were performed to identify factors associated with LNM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 388 patients, 144 (37.11%) had lymph node metastasis. The total number of dissected lymph nodes was 8546, with 341 positive nodes, yielding an LNM degree of 3.99%. Upper thoracic ESCC was more likely to metastasize to upper right paratracheal lymph nodes, while lower thoracic ESCC showed a higher rate of paracardial lymph node metastasis. Tumor differentiation, tumor size, invasion depth, age, and intravascular tumor thrombus were associated with LNM. Multivariate logistic regression analysis revealed that tumor diameter ≥ 3 cm (OR = 2.485, 95% CI 1.483–4.165, <i>p</i> = 0.001) and intravascular tumor thrombus (OR = 7.123, 95% CI 3.101–16.362, <i>p</i> &lt; 0.001) were independent risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Upper esophageal SCC tends to metastasize to upper mediastinal lymph nodes, whereas abdominal and paracardial lymph node metastasis is more common in lower esophageal SCC. Tumor size and intravascular tumor thrombus are independent risk factors for lymph node metastasis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 3","pages":"229-235"},"PeriodicalIF":3.1,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Spectrum of Biopsy-Proven Renal Diseases in Chinese Elderly Patients and Its Temporal Shift Over 20 Years: A Retrospective Cohort Study","authors":"Shasha Han,&nbsp;Lengnan Xu,&nbsp;Ying Sun,&nbsp;Fang Fang,&nbsp;Xin Liu","doi":"10.1002/agm2.70093","DOIUrl":"10.1002/agm2.70093","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To investigate the longitudinal pathological changes in the spectrum of biopsy-proven renal diseases among elderly patients over the past 20 years at a single center in China.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We retrospectively enrolled patients aged ≥ 60 years who underwent renal biopsy at Beijing Hospital between January 2005 and December 2024. Patients were stratified into four 5-year periods (2005–2009, 2010–2014, 2015–2019, and 2020–2024) based on biopsy date. The frequency and distribution of biopsy-proven renal diseases across these periods were analyzed.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 594 elderly patients were included, accounting for 29.2% of all native biopsies in our cohort. The mean age was 67.9 ± 5.7 years, with a male-to-female ratio of 1.4:1. The proportion of elderly patients undergoing renal biopsy increased significantly across the four periods (19.1%, 22.5%, 33.9%, 38.9%; &lt;i&gt;χ&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; = 60.160, &lt;i&gt;p&lt;/i&gt; &lt; 0.01). Nephrotic syndrome (NS) was the most common indication for biopsy, although its proportion declined over time. In contrast, the proportion of biopsies performed for chronic kidney disease (CKD) increased substantially. Primary glomerular nephropathy (PGN), secondary glomerular nephropathy (SGN), and tubulointerstitial nephropathy (TIN) accounted for 54%, 39.9%, and 6.1% of all cases, respectively. The most prevalent cause of PGN was membranous nephropathy (MN), and the leading pathological types of SGN included diabetic nephropathy (DN), antineutrophil cytoplasmic antibody-associated vasculitis (AAV), and hypertensive nephropathy (HTN). Throughout the study period, the proportion of PGN decreased significantly (64.6%, 64.9%, 54.1%, 42.6%; &lt;i&gt;χ&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; = 18.5, &lt;i&gt;p&lt;/i&gt; &lt; 0.001), driven by a decline in MN (34.1%, 39.6%, 32.6%, 23%; &lt;i&gt;χ&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; = 10.015, &lt;i&gt;p&lt;/i&gt; = 0.018). Conversely, the proportion of SGN increased markedly (29.3%, 32.4%, 39.4%, and 49.2%; &lt;i&gt;χ&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; = 13.0, &lt;i&gt;p&lt;/i&gt; = 0.004), primarily due to rising trends in DN and HTN. Notably, during the period 2020–2024, SGN surpassed PGN as the predominant form of biopsy-proven renal diseases among elderly individuals.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The utilization of renal biopsy in elderly patients has increased significantly over the past two decades. While NS remains the most common indication, a notable rise in biopsies for CKD has been observed. The pathological spectrum has undergone a significant shift, characterized by a dr","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 3","pages":"258-264"},"PeriodicalIF":3.1,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"85-88"},"PeriodicalIF":2.5,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148076645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Disparities in the Prevalence, Trends, and Determinants of Later-Life Urinary Incontinence: A Disproportionate Burden on Women.","authors":"Xiyin Chen, Shaoxiang Jiang, Muqi Guo, Hao Zhang, Mouwang Zhou, Yao Yao","doi":"10.1002/agm2.70081","DOIUrl":"10.1002/agm2.70081","url":null,"abstract":"<p><strong>Objectives: </strong>Urinary incontinence (UI) significantly deteriorates the quality of life in the elderly, with a disproportionately higher burden among women. With populations aging in the USA and the UK, understanding the gender-specific prevalence, determinants, and future care needs in UI is critical for shaping gender-responsive health policies and care strategies.</p><p><strong>Methods: </strong>Data from the Health and Retirement Study (HRS, 2010-2020) and the English Longitudinal Study of Aging (ELSA, 2009-2019) involving participants aged 50 and older were analyzed. UI was assessed through self-reported urinary leakage during the last 12 months. The prevalence, determinants, and future care needs were estimated by gender.</p><p><strong>Results: </strong>The analysis included 111,049 and 52,972 observations from HRS and ELSA, respectively. The findings revealed a steady increase in UI prevalence during the 2010s in males (HRS 11.2%-15.1%, ELSA 7.2%-12.0%) and females (HRS 31.4%-36.3%, ELSA 21.0%-28.1%). Contributory factors included aging, higher education levels, and comorbidities. Projections indicate a rise in UI-related care needs in the USA (HRS Female: from 22.1 to 25.7 million, Male: from 7.8 to 9.8 million) and the UK (ELSA Female: from 3.6 to 4.2 million, Male: from 1.4 to 1.6 million) during the 2020s, with women accounting for 65% of this growth, among which the fastest growth was among those aged 80 and over.</p><p><strong>Conclusions: </strong>The rising prevalence of UI, particularly among women, alongside population aging in the USA and UK necessitates an escalation in gender-responsive expansion of care services. Gender-sensitive counseling on tailored prevention strategies and care services such as weight loss and Kegel exercises should be provided to support quality of life and healthy aging, especially in women.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"9 2","pages":"158-167"},"PeriodicalIF":3.1,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13163935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147933982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}