Aging Medicine最新文献

{"title":"The Development of Acute Outreach Services in Aged Care Facilities (Nursing Homes): Using Telemedicine in Rural Areas","authors":"Daniel Kam Yin Chan","doi":"10.1002/agm2.70013","DOIUrl":"https://doi.org/10.1002/agm2.70013","url":null,"abstract":"<p>The world is experiencing rapid aging according to a report from the United Nations. The demography will shift drastically as the fertility rate falls and people are living longer. In 2021, one in 10 people globally were aged 65 or above. In 2050, this age group is projected to rise to one in six people worldwide [<span>1</span>].</p><p>This demographic shift increases the demand for hospitalization and emergency department (ED) services [<span>2</span>]. In the United States, the older population accounts for over 20% of annual ED visits [<span>3</span>]. This also means an increase in the complexity of acute care cases, with older patients experiencing more geriatric syndromes such as delirium, cognitive impairment, and falls [<span>4</span>]. Furthermore, older people visiting EDs often present with multiple comorbidities, polypharmacy, complex physiologic changes, and multifaceted social and physical needs [<span>4</span>]. These demands have put extra stress on the healthcare system.</p><p>To address this growing need, acute outreach services to long-term aged care facilities (or nursing homes) have been developed in recent years to help reduce hospitalizations and ED presentations from older people dwelling in these facilities [<span>5, 6</span>]. In Australia, these services have been found to be safe, accounting for no unexpected deaths and only 5.3% of older patients presenting to hospital for further investigation or treatment [<span>5</span>]. In one Australian study, ED presentation has been reduced by 10%, and during long-term follow-up, the hospitalization rate is reduced by 36% [<span>5, 7</span>]. Moreover, the cost-benefit analysis shows that the ratio is 1:5, meaning that one dollar spent on acute outreach service will save five dollars if a patient is to be hospitalized. However, the caveat is that adherence to safe inclusion and exclusion criteria is essential, and the experience factor plays a paramount role [<span>5, 7</span>].</p><p>During the COVID pandemic, the use of telemedicine has been accelerated, including for nursing home patients. The efficacy and safety of its use for the treatment of acute illnesses other than COVID in the nursing home setting are less clear in the literature. The first paper of its kind revealed that the safety outcome is comparable to face-to-face [<span>8</span>]. Importantly, the condition under which this is carried out needs to be considered, as the study was undertaken by an experienced team and in a single-center urban setting [<span>8</span>]. Furthermore, the use of telemedicine by geriatricians is accompanied by experienced frontline face-to-face nursing staff and is limited to the weekend service. Hence, the generalization to a rural setting, where recruitment of well-trained nursing staff is more difficult, is unclear. The implication will be of immense importance if telemedicine for acute illnesses is found to be equally safe and efficacious in a rural setting compared with an u","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 2","pages":"89-90"},"PeriodicalIF":2.2,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PseudoCell: A Multivalued Logical Regulatory Network to Investigate Premature Senescence Dynamics and Heterogeneity","authors":"Vinícius Pierdoná,&nbsp;Patrícia Lavandoski,&nbsp;Rafael Moura Maurmann,&nbsp;Guilherme Antônio Borges,&nbsp;Jose Carlos Merino Mombach,&nbsp;Fátima Theresinha Costa Rodrigues Guma,&nbsp;Florencia María Barbé-Tuana","doi":"10.1002/agm2.70020","DOIUrl":"https://doi.org/10.1002/agm2.70020","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Premature cellular senescence is a pivotal process in aging and age-related diseases, triggered by various stressors. However, this is not a homogeneous phenotype, but a heterogeneous cellular state composed of multiple senescence programs with different compositions. Therefore, understanding the complex dynamics of senescence programs requires a systemic approach. We introduce PseudoCell, a multivalued logical regulatory network designed to explore the molecular intricacies of premature senescence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>PseudoCell integrates key senescence signaling pathways and molecular mechanisms, offering a versatile platform for investigating diverse premature senescence programs initiated by different stimuli.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Validation through simulation of classical senescence programs, including oxidative stress-induced senescence and oncogene-induced senescence, demonstrates its ability to replicate molecular signatures consistent with empirical data. Additionally, we explore the role of CCL11, a novel senescence-associated molecule, through simulations that reveal potential pathways and mechanisms underlying CCL11-mediated senescence induction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In conclusion, PseudoCell provides a systematic approach to dissecting premature senescence programs and uncovering novel regulatory mechanisms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 2","pages":"145-155"},"PeriodicalIF":2.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors and Predictive Models for Sarcopenia in Older Adults","authors":"Shiyuan Zhang,&nbsp;Xue Yang,&nbsp;Nina An,&nbsp;Meng Lv,&nbsp;Lanyu Yang,&nbsp;Rui Liu,&nbsp;Song Hu,&nbsp;Weiguo Chen,&nbsp;Wenjing Feng,&nbsp;Yongjun Mao","doi":"10.1002/agm2.70012","DOIUrl":"https://doi.org/10.1002/agm2.70012","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Sarcopenia as an age-related syndrome is marked by a progressive loss of muscle strength and mass or reduced physical function. It is insidious in onset and presents a high prevalence. This study aimed to explore risk factors for sarcopenia in the elderly population and construct predictive models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients (<i>n</i> = 335) aged 60–93 years and received an examination by a dual-energy X-ray absorptiometry (DXA) or a body composition analyzer (InBody) between January 2020 and May 2024 were included. Clinical data and laboratory test results were collected from these subjects. LASSO and logistic regression models were constructed to identify and evaluate significant risk factors for sarcopenia. A nomogram and a decision tree model were established for the prediction of sarcopenia probability in the elderly. Random forest was employed to rank the importance of variables in predicting sarcopenia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The potential risk factors for sarcopenia in this study were body mass index, prealbumin, albumin/globulin ratio, serum creatinine, and phosphorus. A nomogram and a decision tree model were constructed based on the factors, showing a high discriminative ability and a high classification accuracy, respectively. Both models were effective in predicting sarcopenia in the elderly, and the nomogram showed a notably reliable predictive performance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study identified risk factors and developed predictive models for sarcopenia in older adults, contributing to timely intervention and treatment of the disease. The nomogram provided an intuitive way to measure the probability of sarcopenia in the elderly population, and the decision tree model made the assessment of sarcopenia simple and rapid. Both models are helpful for clinical staff in early screening and identifying sarcopenia.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 3","pages":"192-199"},"PeriodicalIF":2.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Blood Glucose Level and Cerebral Small Vessel Disease Markers in Neurologically Asymptomatic, Nondiabetic Individuals","authors":"Xinxin Ma,&nbsp;Fang Liu,&nbsp;Lei Qiu,&nbsp;Juan Chen,&nbsp;Wei Du,&nbsp;Jing He,&nbsp;Aizhen Sheng,&nbsp;Yinhong Liu","doi":"10.1002/agm2.70017","DOIUrl":"https://doi.org/10.1002/agm2.70017","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Cerebral small vascular disease (CSVD) is not rare in neurologically asymptomatic individuals. Glucose control and insulin resistance (IR) may be its risk factors. We aimed to explore the relationship between CSVD markers, glucose control, and IR in neurologically asymptomatic, nondiabetic individuals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 412 participants from the annual physical examinations population in our hospital who underwent brain magnetic resonance imaging from May 2019 to June 2021 were enrolled. We collected clinical data and blood test indices and calculated the triglyceride-glucose (TyG) index. CSVD markers were assessed, including lacunes, white matter hyperintensities (WMH), enlarged perivascular spaces (EPVS), cerebral microbleeds (CMBs), and the total CSVD score. Correlations between CSVD markers, clinical variables, and blood test parameters were analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median age of our group was 70.32 ± 10.27 years (45–103 years). The prevalence of asymptomatic CSVD was 43.7%. Lacunes were present in 8.3%, periventricular WMH (PVWMH) in 65.3%, deep WMH (DWMH) in 64.1%, EPVS in 87.4%, and CMBs in 31.3% of individuals. Glycated hemoglobin A1c (HbA1c) varied between PVWMH subgroups (<i>p</i> = 0.043). Fasting blood glucose (FBG) was higher in individuals with deep CMBs than in those without deep CMBs (<i>p</i> = 0.012). FBG was an independent risk factor for deep CMBs after controlling for multiple variables. However, the TyG index was not associated with CSVD markers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The prevalence of neurologically asymptomatic CSVD is common in the nondiabetic population. It may be beneficial for middle-aged and elderly people to pay attention to their blood glucose levels.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 2","pages":"117-125"},"PeriodicalIF":2.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontiers in Nondrug Treatment of Sarcopenia: A Review of Pathological Mechanisms and the Latest Treatment Strategies","authors":"Qi-Fei Kuang,&nbsp;Yu-Qing Ni,&nbsp;You-Shuo Liu","doi":"10.1002/agm2.70011","DOIUrl":"https://doi.org/10.1002/agm2.70011","url":null,"abstract":"<p>Sarcopenia refers to the progressive decline and wasting of skeletal muscle function, typically linked to aging or as a secondary effect of various conditions, including systemic inflammation, oxidative stress, and mitochondrial dysfunction. Recent scientific research underscores that skeletal muscle function is regulated by multiple factors. These include not only physical activity, environmental exposures, and genetic tendencies, but also nutritional deficiencies. Currently, pharmacological interventions for sarcopenia remain a matter of ongoing debate; the recommended strategies for promoting muscle health center on nutritional support therapy and physical exercise. This review offers an insightful examination of the molecular pathways and Pathophysiology contributing to skeletal muscle atrophy and highlights recent progress in employing nonpharmacological approaches (particularly, nutritional supplementation and physical exercise) for its prevention and management. To provide new scientific evidence and effective strategies for the prevention and treatment of sarcopenia, help to bolster the preservation of skeletal muscle function, and improve the quality of life and health of the elderly.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 3","pages":"200-209"},"PeriodicalIF":2.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Anxiety Symptoms in Older Adults Attending an Outpatient Geriatric Service: A Cross-Sectional Study","authors":"Gianella Grajeda-León,&nbsp;Victoria Azurin-Gonzales,&nbsp;Zulema Mamani-Condori,&nbsp;Alvaro M. Ñaña-Cordova,&nbsp;Marina A. Bustamante-Ordoñez,&nbsp;Fiorella Neyra-Cordova,&nbsp;José F. Parodi,&nbsp;Fernando M. Runzer Colmenares","doi":"10.1002/agm2.70018","DOIUrl":"https://doi.org/10.1002/agm2.70018","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To identify the factors contributing to anxiety among adults aged 65 and older receiving care at the Geriatric Service of the Naval Medical Center.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An analytical study was conducted through secondary analysis of a database from a study carried out between 2010 and 2015 at the Naval Medical Center of Peru (CEMENA). The data from 1686 participants were analyzed, with anxiety as the dependent variable, measured using the Hamilton Anxiety Rating Scale with a cutoff point of 14. The analysis was performed using STATA software. Bivariate analysis was conducted using the chi-squared and Student <i>t</i>-tests, while Poisson regression was employed for multivariate analysis to determine the frequencies and associations between anxiety and the various variables.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the multivariate analysis, anxiety was found to be significantly associated with gait speed (PR 1.11; 95% CI 1.03–1.20), depressive symptoms (PR 1.97; 95% CI 1.81–2.16), polypharmacy (PR 1.14; 95% CI 1.04–1.06), and education level (PR 0.83; 95% CI 0.76–0.90). Additionally, marital status was found to be associated with the likelihood of anxiety: being married (PR 0.64; 95% CI 0.53–0.77), widowed (PR 0.54; 95% CI 0.44–0.66), or divorced (PR 0.63; 95% CI 0.49–0.83) were all linked to a lower probability of anxiety compared to being single.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Factors such as depressive symptoms, polypharmacy, slow gait speed, education level, and marital status were found to be associated with anxiety in older adults.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 2","pages":"99-106"},"PeriodicalIF":2.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patchouli Ethanol Extract Pogostemon cablin Benth. Against Aging Profiles in Doxorubicin-Induced 3T3-L1 Fibroblast Cell Lines","authors":"Teguh Santoso,&nbsp;Astrid Feinisa Khairani,&nbsp;Muhammad Hasan Bashari,&nbsp;Julia Ramadhanti,&nbsp;Enny Rohmawati,&nbsp;Monika Pury Oktora,&nbsp;Hesti Lina Wiraswati","doi":"10.1002/agm2.70014","DOIUrl":"https://doi.org/10.1002/agm2.70014","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This research aimed to investigate the potential of \u0000 <i>Pogostemon cablin</i>\u0000 Benth's ethanolic extract (PCEE) as an antiaging agent.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We treated 3T3-L1 cells induced by doxorubicin with PCEE and assessed them with antiaging markers such as <i>GLB-1</i> gene and telomere length with polymerase chain reaction (PCR), or reactive oxygen species (ROS) accumulation with 2,7-dichlorofluorescein diacetate (DCFHDA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This study demonstrates that PCEE can inhibit ROS accumulation, decrease the expression level of the senescence-associated β-galactosidase (SA-β-gal) <i>gene, GLB-1,</i> and maintain telomere length in doxorubicin-induced 3T3-L1 cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These studies reveal that PCEE is a promising antiaging agent. An in vivo approach should be conducted for further research.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 2","pages":"156-163"},"PeriodicalIF":2.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Clinical Scores for Predicting Stroke-Associated Pneumonia After Acute Ischemic Stroke","authors":"Linlin Wang,&nbsp;Jun Xu,&nbsp;Xinyu Liu,&nbsp;Feifei Ma,&nbsp;Xingquan Zhao,&nbsp;Anxin Wang,&nbsp;Ruijun Ji,&nbsp;Yongjun Wang,&nbsp;CNSR III investigators","doi":"10.1002/agm2.70003","DOIUrl":"https://doi.org/10.1002/agm2.70003","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To compare the discrimination and calibration of six risk scoring systems in the assessment of patients with stroke-associated pneumonia (SAP) after acute ischemic stroke.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The validation cohort was derived from the Third China National Stroke Registry. SAP was diagnosed according to the criteria for hospital-acquired pneumonia of the Centers for Disease Control and Prevention. The area under the receiver operating characteristic curve (AUROC) and Hosmer-Lemeshow goodness-of-fit test were used to assess discrimination and calibration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 12,071 patients were included in the study and 606 (5.02%) patients were diagnosed with in-hospital SAP after ischemic stroke. The AUROC of the six clinical scores ranged from 0.660 to 0.752. In the pairwise comparison, the AIS-APS score (0.752, 95% CI = 0.730–0.773, <i>p</i> &lt; 0.001) showed significantly better discrimination than the other risk models, except the PASS score. The AIS-APS score had the largest Cox and Snell <i>R</i>\u0000 ² for in-hospital SAP after ischemic stroke. In the subgroup analysis, among patients over 61 years of age, all TOAST subtypes except small vessel disease, length of hospital stay longer than 8 days, male and female sex, different groups stratified by admission NIHSS score and time from onset to arrival, the AIS-APS score showed better discrimination than other risk models with regard to SAP after AIS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study compared the discrimination and calibration of the Kwon Pneumonia Score, A2DS2 score, PANTHERIS score, AIS-APS score, ISAN score, and PASS score in SAP identification; of these, the AIS-APS score showed the best performance.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 2","pages":"137-144"},"PeriodicalIF":2.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HDL-Apolipoprotein in Alzheimer's Disease Revisited: From Periphery to CNS","authors":"Yihong Huang,&nbsp;Jingyi Tang,&nbsp;Guohua Chen,&nbsp;Qiangqiang Wu,&nbsp;Yongfei Wang,&nbsp;Jianjun Chen,&nbsp;Simei Chen,&nbsp;Jun Liu,&nbsp;Xiaoyun Huang","doi":"10.1002/agm2.70008","DOIUrl":"https://doi.org/10.1002/agm2.70008","url":null,"abstract":"<p>High-density lipoprotein (HDL), as a crucial component of lipid metabolism, have roles in regulating Alzheimer's disease (AD) core pathology amyloid β (Aβ) and phosphorylated tau (p-tau) through its apolipoproteins, which are associated with brain structures, cognition, and risk of dementia. The pool of HDL apolipoproteins—in the brain and in the periphery—has its own distinct origin, composition, and regulatory mechanisms. It remains unclear whether these apolipoproteins in the periphery and CNS play distinct roles in the pathogenesis of AD. Specifically, this review focus on the distinct associations of apolipoprotein AI and apolipoprotein E—the major components of HDL in the blood and CSF—with pathological proteins, brain integrity, cognition, and dementia progression in AD. We summarize and examine the current state of knowledge on the values of these apolipoproteins in AD pathogenesis and clinical potential.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 2","pages":"164-177"},"PeriodicalIF":2.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Immunosenescence on Immune-Related Adverse Events in Elderly Patients With Cancer","authors":"Jiayi Gao,&nbsp;Yue Yuan,&nbsp;Xue Wang,&nbsp;Liuer He,&nbsp;Lin Li","doi":"10.1002/agm2.70000","DOIUrl":"https://doi.org/10.1002/agm2.70000","url":null,"abstract":"<p>Immune checkpoint inhibitors (ICI), have transformed the management of several types of cancers; however, immune-related adverse events (irAEs) may cause treatment interruptions, chronic toxic effects, and death. Elderly patients are at high risk of cancer. Compared with traditional chemotherapy, immunotherapy has become a better alternative choice for elderly patients with cancer due to its high efficiency and low toxicity. However, the emergence of immunosenescence accompanied by advancing age raises safety concerns for ICI. Therefore, we summarize the characteristics of irAEs occurred in elderly patients with cancer and the physiological characteristics of immunosenescence, which will lay a theoretical foundation for the safety management of immunotherapy in elderly patients with cancer.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}