Amr Badary, Sarah Zuhair Kurdi, Yasser F. Almealawy, Sura N. Alrubaye, Vivek Sanker, Bipin Chaurasia, Oday Atallah
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Outcomes assessed were postoperative complications, recurrence rates, and functional status. Statistical analysis used SPSS version 26, with significance set at <i>p</i> < 0.05.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The cohort was predominantly male (87.0%), with a mean age of 27 years. Tumors were mostly in the fourth ventricle (82.6%), with an average diameter of 68.9 mm. Complete resection was achieved in 87.0% of cases. Postoperative radiotherapy was given to 91.0% of grade 2 and all grade 3 tumors. Recurrence occurred in 17.4% of grade 2 ependymomas, but none of grade 3. The seven-month mortality rate was 4.3%. Higher preoperative KPSS scores correlated with better outcomes.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Complete tumor resection and postoperative radiotherapy are crucial for improved outcomes in ependymomas. Higher preoperative KPSS scores and tumor location significantly impact prognosis. Tumors in the lateral ventricles are associated with higher recurrence risks. These findings highlight the need for aggressive surgical management and personalized adjuvant therapy to enhance patient outcomes.</p>\n </section>\n </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"679-688"},"PeriodicalIF":2.2000,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702391/pdf/","citationCount":"0","resultStr":"{\"title\":\"Intracranial ependymoma: A retrospective analysis of clinical features, treatment modalities, and long-term outcome\",\"authors\":\"Amr Badary, Sarah Zuhair Kurdi, Yasser F. Almealawy, Sura N. 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Statistical analysis used SPSS version 26, with significance set at <i>p</i> < 0.05.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The cohort was predominantly male (87.0%), with a mean age of 27 years. Tumors were mostly in the fourth ventricle (82.6%), with an average diameter of 68.9 mm. Complete resection was achieved in 87.0% of cases. Postoperative radiotherapy was given to 91.0% of grade 2 and all grade 3 tumors. Recurrence occurred in 17.4% of grade 2 ependymomas, but none of grade 3. The seven-month mortality rate was 4.3%. Higher preoperative KPSS scores correlated with better outcomes.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Complete tumor resection and postoperative radiotherapy are crucial for improved outcomes in ependymomas. Higher preoperative KPSS scores and tumor location significantly impact prognosis. Tumors in the lateral ventricles are associated with higher recurrence risks. 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引用次数: 0
摘要
目的:室管膜瘤是一种罕见的起源于室管膜细胞的神经胶质肿瘤,可发生在中枢神经系统,通常影响脑室或脊髓。预后受肿瘤分级、位置、切除程度和术前Karnofsky Performance Status Scale (KPSS)评分的影响。本研究评估颅内室管膜瘤患者的临床特征、治疗结果和影响预后的因素。方法:回顾性分析2018 - 2023年收治的23例颅内室管膜瘤患者的临床资料。数据包括人口统计学、临床表现、KPSS评分、影像学结果和治疗细节。评估的结果包括术后并发症、复发率和功能状态。统计学分析采用SPSS 26版本,显著性设置为p。结果:队列以男性为主(87.0%),平均年龄27岁。肿瘤以第四脑室居多(82.6%),平均直径68.9 mm。87.0%的病例完全切除。91.0%的2级肿瘤和所有3级肿瘤术后给予放疗。17.4%的2级室管膜瘤复发,而3级室管膜瘤无复发。7个月死亡率为4.3%。术前KPSS评分越高,预后越好。结论:肿瘤完全切除和术后放疗是改善室管膜瘤预后的关键。术前较高的KPSS评分和肿瘤位置对预后有显著影响。侧脑室肿瘤有较高的复发风险。这些发现强调需要积极的手术管理和个性化的辅助治疗来提高患者的预后。
Intracranial ependymoma: A retrospective analysis of clinical features, treatment modalities, and long-term outcome
Objective
Ependymomas, rare neuroglial tumors originating from ependymal cells, can occur in the CNS and typically affect the brain's ventricles or spinal cord. Prognosis is influenced by tumor grade, location, resection extent, and preoperative Karnofsky Performance Status Scale (KPSS) scores. This study evaluates clinical features, treatment outcomes, and factors affecting prognosis in patients with intracranial ependymomas.
Methods
A retrospective review of 23 patients with intracranial ependymomas, treated from 2018 to 2023, was conducted. Data included demographics, clinical presentations, KPSS scores, imaging findings, and treatment details. Outcomes assessed were postoperative complications, recurrence rates, and functional status. Statistical analysis used SPSS version 26, with significance set at p < 0.05.
Results
The cohort was predominantly male (87.0%), with a mean age of 27 years. Tumors were mostly in the fourth ventricle (82.6%), with an average diameter of 68.9 mm. Complete resection was achieved in 87.0% of cases. Postoperative radiotherapy was given to 91.0% of grade 2 and all grade 3 tumors. Recurrence occurred in 17.4% of grade 2 ependymomas, but none of grade 3. The seven-month mortality rate was 4.3%. Higher preoperative KPSS scores correlated with better outcomes.
Conclusion
Complete tumor resection and postoperative radiotherapy are crucial for improved outcomes in ependymomas. Higher preoperative KPSS scores and tumor location significantly impact prognosis. Tumors in the lateral ventricles are associated with higher recurrence risks. These findings highlight the need for aggressive surgical management and personalized adjuvant therapy to enhance patient outcomes.