Aging Medicine最新文献

{"title":"Craniectomy versus craniotomy: What can we do for acute subdural hematoma?","authors":"Shuo Zhang, Guoyi Gao, Weiming Liu","doi":"10.1002/agm2.12322","DOIUrl":"10.1002/agm2.12322","url":null,"abstract":"<p>Acute subdural hematoma (ASDH) is one of the common complications after traumatic brain injury (TBI) that warrants surgical evacuation. It often progresses rapidly and has a poor clinical prognosis, due to the mass effect caused by the hematoma and the invasion of the adjacent cerebral cortex and parenchyma. Although with the advancement of surgical techniques, the survival rate after ASDH increased from 59% in 1994–1998 to 73% in 2009–2013,<span><sup>1</sup></span> the surgical indications for hematoma evacuation and whether to perform decompression surgery are still controversial which depends on the patient's level of consciousness, pupil status, neuroimaging findings, and intracranial pressure.<span><sup>2</sup></span> Hematoma evacuation is required in a quarter of patients to save lives.<span><sup>3-5</sup></span> At the same time, craniectomy was performed in another 25% of these patients to prevent postoperative brain edema or intraoperative brain tissue swelling, this proportion can be as high as nearly 50% in patients with severe traumatic brain injury in China.<span><sup>6</sup></span> In most cases, the primary motivation for emergency hematoma removal is to save lives or the noticeable space-occupying effect on computed tomography (CT) images,<span><sup>4</sup></span> however, if the intracranial pressure during emergency surgery allows, whether to remove the bone flap is an essential factor that probably affect the prognosis of patients.</p><p>Recently, in the New England Journal of Medicine, P. J. Hutchinson and colleagues address the comparison of surgical outcomes of craniotomy and decompressive craniectomy (RESCUE-ASDH trial),<span><sup>7</sup></span> it is an investigator-initiated, international, multicenter, pragmatic, randomized trial of patent with a bone flap greater than 11 cm in diameter who accepted the hematoma evacuation. Extended Glasgow Outcome Scale (GOSE) was used to evaluate patients’ outcomes after surgery 12 months later. The mortality and prognosis of the decompressive craniectomy and craniotomy groups were compared at 1, 6 months, and 1 year after operation, and there was no significance in disability and quality-of-life outcomes between two groups. However, the craniotomy group may have to face re-surgery due to difficult-to-control brain edema, while the decompressive craniectomy group may face more trauma-related complications.</p><p>The key conclusions of RESCUE-ASDH trial provide an essential reference for the decision-making of whether to remove the bone flap during the subdural hematoma surgery, that is, if no encephalocele occurs immediately during the operation, reduction of the skull with brain tissue no higher than the plane level of the skull does not increase the risk of poor prognosis. The conclusions are consistent with the recent findings of Thomas A. van Essen et al.,<span><sup>5</sup></span> which pose a significant challenge to previous clinical practice.</p><p>Compared with intracranial","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"276-278"},"PeriodicalIF":2.2,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12322","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141343670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global research and scientific publications on PND between 1969 and 2022: A bibliometric analysis","authors":"Ruoxuan Liu, Duan Gao, Ning Yang, Yu Qiao, Zihang Zhang, Mingzhang Zuo","doi":"10.1002/agm2.12310","DOIUrl":"10.1002/agm2.12310","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>We hope to offer a comprehensive understanding of the advancements and patterns in research on PND. Methods: We performed a thorough search on the Web of Science Core Collection to locate relevant studies published from 1969 to 2022 and utilized four distinct tools, namely VOSviewer (J Data Inf Sci, 2017, 2, 1; J Am Soc Inf Sci, 1973, 24, 265; Amer Doc, 1963, 14, 10 and Scientometrics, 2010, 82, 581), CiteSpace (Scientometrics, 2010, 84, 523), Scimago Graphica, and R-bibliometrix which allowed us to examine various aspects. Results: We included a total of 6787 articles and reviews for analysis which described PND research, the sources, and the subfields; highlighted the significant developments in this field; identified three main directions in PND.Conclusion: This study highlights the rapid growth of research on PND in recent years and provided an overview of previous studies in the field of PND, thereby establishing the overall landscape of PND research and identifying potential avenues for future investigations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed a thorough search on the Web of Science Core Collection to locate relevant studies published from 1969 to 2022. To perform bibliometric analysis and network visualization, we utilized four distinct tools, namely VOSviewer (J Data Inf Sci, 2017, 2, 1; J Am Soc Inf Sci, 1973, 24, 265; Amer Doc, 1963, 14, 10 and Scientometrics, 2010, 82, 581), CiteSpace (Scientometrics, 2010, 84, 523), Scimago Graphica, and R-bibliometrix. These tools allowed us to examine various aspects, including the yearly publication output, the contribution of different countries or regions, the involvement of active journals, co-citation analysis, publication status, keywords, and terms, as well as scientific categories. We hope to offer a comprehensive understanding of the advancements and patterns in research on PND. The insights gained from this study can assist researchers and clinicians in enhancing the management and implementation of their work in this field.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In this study, we included a total of 6787 articles and reviews for analysis. First, publication trends and contribution by country analysis described PND research. Second, a historical analysis described PND research, the sources, and the subfields. Third, an analysis of keywords highlighted the significant developments in this field. Fourth, an analysis of research themes identified three main directions in PND.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"368-383"},"PeriodicalIF":2.2,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12310","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141339868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory bibliometric analysis and text mining to reveal research trends in cardiac aging","authors":"Takahiro Kamihara,&nbsp;Ken Tanaka,&nbsp;Takuya Omura,&nbsp;Shinji Kaneko,&nbsp;Akihiro Hirashiki,&nbsp;Manabu Kokubo,&nbsp;Atsuya Shimizu","doi":"10.1002/agm2.12329","DOIUrl":"10.1002/agm2.12329","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>We conducted a text mining analysis of 40 years of literature on cardiac aging from PubMed to investigate the current understanding on cardiac aging and its mechanisms. This study aimed to embody what most researchers consider cardiac aging to be.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used multiple text mining and machine learning tools to extract important information from a large amount of text.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Analysis revealed that the terms most frequently associated with cardiac aging include “diastolic,” “hypertrophy,” “fibrosis,” “apoptosis,” “mitochondrial,” “oxidative,” and “autophagy.” These terms suggest that cardiac aging is characterized by mitochondrial dysfunction, oxidative stress, and impairment of autophagy, especially mitophagy. We also revealed an increase in the frequency of occurrence of “autophagy” in recent years, suggesting that research on autophagy has made a breakthrough in the field of cardiac aging. Additionally, the frequency of occurrence of “mitophagy” has increased significantly since 2019, suggesting that mitophagy is an important factor in cardiac aging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Cardiac aging is a complex process that involves mitochondrial dysfunction, oxidative stress, and impairment of autophagy, especially mitophagy. Further research is warranted to elucidate the mechanisms of cardiac aging and develop strategies to mitigate its detrimental effects.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"301-311"},"PeriodicalIF":2.2,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12329","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141343278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haste makes waste: Early nutrition prescription for critically ill patients","authors":"Siying Chen,&nbsp;Zhigang Chang","doi":"10.1002/agm2.12337","DOIUrl":"10.1002/agm2.12337","url":null,"abstract":"&lt;p&gt;The Nutrirea-3 study was an impactful, multicenter, open-label parallel-group randomized controlled trial (RCT) conducted in 61 intensive care units (ICUs) across France.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; The study included patients who were receiving invasive mechanical ventilation and vasopressor therapy for shock, with a median Sequential Organ Failure Assessment (SOFA) score of 10 (8–13) and a median Simplified Acute Physiology Score (SAPS) II of 60 (48–74 points, study group) and 61 (48–74 points, control group), respectively. In total, 3044 patients were randomized into two groups: the low-calorie, low-protein study group (6 kcal/kg/day, 0.2–0.4 g/kg/day) and the standard-calorie, standard-protein control group (25 kcal/kg/day, 1.3 g/kg/day). Enteral nutrition (EN) was administered continuously for 24 h at a constant rate to achieve caloric and protein targets on the first day. The primary outcomes were 90-day all-cause mortality and the number of days until the ICU discharge criteria were met. The secondary outcomes included the rates of secondary infections, gastrointestinal (GI) events, and liver dysfunction. There was no difference in 90-day mortality between the two groups, indicating that high or low calorie and protein intake during the first week did not affect the 90-day mortality rate. The patients in the study group met the ICU discharge criteria 1 day earlier than did those in the control group. Regarding the secondary outcomes, the low-calorie feeding group exhibited lower rates of vomiting, diarrhea, intestinal ischemia, and liver dysfunction, suggesting that increased feeding may be harmful.&lt;/p&gt;&lt;p&gt;In the past, there was a notion that early and adequate nutrition could improve outcomes, where “adequate” meant achieving sufficient energy intake goals in the early stages of critical illness. However, the publication of the EPaNIC trial in 2011 led to skepticism about this concept.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; In this trial, patients who received early supplemental parenteral nutrition (PN) had adverse outcomes that were initially attributed to PN itself. This interpretation led to a significant reduction in the use of PN in clinical practice and recommendations against the use of PN in guidelines.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; Since then, accumulating evidence has suggested that providing complete energy targets (i.e., managing nutrition to cover estimated energy expenditure entirely) is detrimental rather than beneficial, regardless of the delivery route. This suggests that clinicians may overestimate patients' energy needs, overfeed patients, or, conversely, encounter biological benefits associated with underfeeding in patients. Some studies have evaluated potential biological mechanisms underlying previous unexpected findings, such as an increased endogenous energy supply independent of the exogenous energy supply and the nutritional suppression of autophagy.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;In the Nutrirea-3 study, patients in the standard f","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"279-282"},"PeriodicalIF":2.2,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12337","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141343772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between advanced lung cancer inflammation index and in-hospital mortality in ICU patients with community-acquired pneumonia: A retrospective analysis of the MIMIC-IV database","authors":"Feng Yang,&nbsp;Lianjun Gao,&nbsp;Cuiping Xu,&nbsp;Qimin Wang,&nbsp;Wei Gao","doi":"10.1002/agm2.12334","DOIUrl":"10.1002/agm2.12334","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The objective of the present study was to explore the correlation between the advanced lung cancer inflammation index (ALI) and in-hospital mortality among patients diagnosed with community-acquired pneumonia (CAP).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data from the Medical Information Mart for Intensive Care-IV database were adopted to analyze the in-hospital mortality of ICU patients with CAP. Upon admission to the ICU, fundamental data including vital signs, critical illness scores, comorbidities, and laboratory results, were collected. The in-hospital mortality of all CAP patients was documented. Multivariate logistic regression (MLR) models and restricted cubic spline (RCS) analysis together with subgroup analyses were conducted.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This study includes 311 CAP individuals, involving 218 survivors as well as 93 nonsurvivors. The participants had an average age of 63.57 years, and the females accounted for approximately 45.33%. The in-hospital mortality was documented to be 29.90%. MLR analysis found that ALI was identified as an independent predictor for in-hospital mortality among patients with CAP solely in the Q1 group with ALI ≤ 39.38 (HR: 2.227, 95% CI: 1.026–4.831, <i>P</i> = 0.043). RCS analysis showed a nonlinear relationship between the ALI and in-hospital mortality, with a turning point at 81, and on the left side of the inflection point, a negative correlation was observed between ALI and in-hospital mortality (HR: 0.984, 95% CI: 0.975–0.994, <i>P</i> = 0.002). The subgroup with high blood pressure showed significant interaction with the ALI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The present study demonstrated a nonlinear correlation of the ALI with in-hospital mortality among individuals with CAP. Additional confirmation of these findings requires conducting larger prospective investigations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"350-359"},"PeriodicalIF":2.2,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12334","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141338939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of L-oxiracetam and oxiracetam on memory and cognitive impairment in mild-to-moderate traumatic brain injury patients: Study protocol for a randomized controlled trial","authors":"Tao Liu,&nbsp;Mingqi Liu,&nbsp;Meng Nie,&nbsp;Zhihao Zhao,&nbsp;Xuanhui Liu,&nbsp;Yu Qian,&nbsp;Yunhu Yu,&nbsp;Zhuang Sha,&nbsp;Chenrui Wu,&nbsp;Jiangyuan Yuan,&nbsp;Weiwei Jiang,&nbsp;Chuanxiang Lv,&nbsp;Liang Mi,&nbsp;Yu Tian,&nbsp;Jianning Zhang,&nbsp;Rongcai Jiang","doi":"10.1002/agm2.12335","DOIUrl":"10.1002/agm2.12335","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Patients with traumatic brain injury (TBI) often suffer memory and cognitive impairments, and oxiracetam-like drugs are considered to have a positive impact on these symptoms potentially. However, the efficacy and safety of <span>L</span>-oxiracetam and oxiracetam in TBI patients have not been sufficiently investigated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study adopts a multicenter, randomized, double-blind, parallel-group, phase 3 clinical trial design in 74 centers across 51 hospitals in China. A total of 590 TBI patients meeting criteria will be randomly allocated into three groups in a 2:2:1 ratio: <span>L</span>-oxiracetam group, oxiracetam group, and placebo group. The treatment period is 14 days, with a follow-up period of 90 days. The primary outcome measure is the change in the Loewenstein Occupational Therapy Cognitive Assessment score at 90 days after treatment. Secondary outcomes include changes in other cognitive assessments, neurological function, activities of daily living, and safety assessments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>There is no robust evidence to suggest that <span>L</span>-oxiracetam and oxiracetam can enhance memory and cognitive function in patients with mild to moderate TBI. This study has the potential to answer this crucial clinical question.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial registration</h3>\u0000 \u0000 <p>chinadrugtrials.org.cn, identifier CTR20192539; ClinicalTrials.gov, identifier NCT04205565.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"341-349"},"PeriodicalIF":2.2,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12335","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141343803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota in centenarians: A potential metabolic and aging regulator in the study of extreme longevity","authors":"Ivan David Lozada-Martinez,&nbsp;Luz Miryam Lozada-Martinez,&nbsp;Juan-Manuel Anaya","doi":"10.1002/agm2.12336","DOIUrl":"10.1002/agm2.12336","url":null,"abstract":"<p>Centenarians, those aged 100 years or older, are considered the most successful biological aging model in humans. This population is commonly characterized by a low prevalence of chronic diseases, with favorable maintenance of functionality and independence, thus determining a health phenotype of successful aging. There are many factors usually associated with extreme longevity: genetics, lifestyles, diet, among others. However, it is most likely a multifactorial condition where protective factors contribute individually to some extent. The gut microbiota (GM) has emerged as a potential factor associated with the establishment of a favorable health phenotype that allows for extreme longevity, as seen in centenarians. To understand the possible impact generated by the GM, its changes, and the probable causes for successful aging, the aim of this review was to synthesize evidence on the role of the GM as a potential protective factor for achieving extreme longevity, using its relationship with centenarians.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"406-413"},"PeriodicalIF":2.2,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12336","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141339085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The original scores of traditional Chinese medicine constitutions are risk and diagnostic factors in middle-aged and older adults with sarcopenia","authors":"Xin Nie,&nbsp;Chi Wang,&nbsp;He Zhang,&nbsp;Qianhui Liu,&nbsp;Lisha Hou,&nbsp;Yiping Deng,&nbsp;Wenbin Ye,&nbsp;Jirong Yue,&nbsp;Yong He","doi":"10.1002/agm2.12328","DOIUrl":"10.1002/agm2.12328","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Sarcopenia is a geriatric syndrome that occurs with age and is characterized by a gradual decline in muscle mass, power, and functionality. It serves as a prominent contributor to frailty, disability, and mortality among older individuals. Currently, no standardized global guidelines exist for the diagnosis of sarcopenia. This study aimed to establish the correlation between sarcopenia and the constitutions of traditional Chinese medicine (TCM), considering the connection between physical functioning and sarcopenia.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 1441 participants in this study were diagnosed with sarcopenia. The Asian Working Group for Sarcopenia (AWGS) proposed a sarcopenia definition algorithm. To determine the constitution of each participant, classification and determination standards were used in traditional Chinese medicine. This study evaluated the demographics, lifestyles, and self-reported medical history of individuals diagnosed with sarcopenia through a self-administered questionnaire. The constitution of the participants was determined using TCM classification and determination standards. Subsequently, we analyzed the results of univariate analysis and multivariate regression and constructed a receiver operating characteristic (ROC) curve.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Participants who were diagnosed with sarcopenia had substantially lower original Neutral constitution scores (&lt;i&gt;P&lt;/i&gt; &lt; 0.050). In comparison to those without sarcopenia, individuals with sarcopenia exhibited notably elevated original Qi-deficiency, Yang-deficiency, Yin-deficiency, Blood-stagnation, and Qi-stagnation scores in contrast to those in the healthy group (&lt;i&gt;P&lt;/i&gt; &lt; 0.050). The identified risk factors associated with sarcopenia included the following: Neutral (OR = 0.903), Qi-deficiency (in males, OR = 1.126), Yang-deficiency (OR = 1.062), Phlegm-dampness (in males, OR = 0.833), and Blood-stagnation (in females, OR = 1.089). The highest area under the curve (AUC) was observed for the original neutral constitution score, followed by the Yang-deficiency and blood-stagnation scores (0.644, 0.613, and 0.611, respectively). Additionally, the AUC for the combined original scores of all nine constitutions among males reached 0.778.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In this cross-sectional study of older people with higher original Qi-deficiency, Yin deficiency, Yang-deficiency, Blood-stagnation, and Qi-stagnation were associated with sarcopenia. Notably, various TC","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"334-340"},"PeriodicalIF":2.2,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12328","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141344667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body composition characteristics and influencing factors of different parts of sarcopenia in elderly people: A community-based cross-sectional survey","authors":"Xinying Dong,&nbsp;Bingqing Bi,&nbsp;Yifei Hu,&nbsp;Li Wang,&nbsp;Xinying Liu,&nbsp;Wentao Li,&nbsp;Mingyue Li,&nbsp;Tong Xiang,&nbsp;Shugang Li,&nbsp;Hao Wu","doi":"10.1002/agm2.12327","DOIUrl":"10.1002/agm2.12327","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aims to describe the differences in body composition among different body parts of the elderly in the community and its relationship with sarcopenia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Elderly people aged ≥65 underwent bioelectric impedance analysis testing and were categorized into a sarcopenia group, possible sarcopenia group, and control group. The characteristics of body composition indicators in different parts and their relationship with different stages of sarcopenia were analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The sarcopenia group illustrated the lowest values of FFM, FFM%, BFM, BFM%, ICW, and limb PhA, along with higher ECW/TBW in the trunk and left leg compared to the control group. The possible sarcopenia group showed lower FFM% in limbs and trunk, and higher BFM% compared to the control group. Gender differences in elderly body composition were observed, with an increase in BFM% in various body parts posing a risk factor for possible sarcopenia in elderly males, whereas an increase in BFM% except in the left arm was a protective factor for sarcopenia in elderly females.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The body composition of the elderly in the community varied significantly in different stages of sarcopenia and genders, which correlated with sarcopenia.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"384-392"},"PeriodicalIF":2.2,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12327","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141340819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How can precision health care contribute to healthy aging?","authors":"Jean-Pierre Michel","doi":"10.1002/agm2.12333","DOIUrl":"10.1002/agm2.12333","url":null,"abstract":"<p>The future of medicine will be closely linked to technological progress, to the great benefit of aging adults. Increasing knowledge in fields encompassing biology, physiology and functioning of the aging process, combined with the early detection of non-clinically apparent but significant changes will make it possible to promote healthy aging.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"269-271"},"PeriodicalIF":2.2,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12333","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141354306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}