Aging Medicine最新文献

{"title":"Delta-like ligand 3: A promising target against small cell lung cancer","authors":"Xin Nie,&nbsp;Yu-meng Tian,&nbsp;Yue Yuan,&nbsp;Lin Li","doi":"10.1002/agm2.12311","DOIUrl":"https://doi.org/10.1002/agm2.12311","url":null,"abstract":"<p>This commentary highlighted the current knowledge about novel DLL3-targeting agents for refractory small cell lung cancer.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"283-286"},"PeriodicalIF":2.2,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12311","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First study with positive cardiovascular outcome in obesity: Reflections on SELECT","authors":"Qi Pan,&nbsp;Sijia Fei,&nbsp;Ting Xie,&nbsp;Lixin Guo","doi":"10.1002/agm2.12300","DOIUrl":"10.1002/agm2.12300","url":null,"abstract":"<p>At present, medications of the GLP-1RA class, such as liraglutide 3.0 mg,<span>²⁷</span> semaglutide 2.4 mg,<span>²⁸</span> and tirzepatide (GLP-1/GIP [glucose-dependent insulinotropic polypeptide] agonist)<span>²⁹</span> have been approved for weight management for adult patients with obesity or overweight with obesity-related complications. The previous study of semaglutide 2.4 mg in obese patients with heart failure, the STEP-HFpEF study,<span>²²</span> confirmed its significant improvement in clinical functional endpoints such as KCCQ-CSS score (Kansas City Cardiomyopathy Questionnaire clinical summary score) and 6MWD (6-Minute Walk Distance) for patients with heart failure and preserved/mildly reduced ejection fraction (HFpEF/HFmrEF), demonstrating the cardiovascular benefit of semaglutide 2.4 mg in patients with obesity. SELECT further confirmed that semaglutide 2.4 mg significantly reduced the risk of major cardiovascular events. As the first weight management drug with cardiovascular benefit confirmed by rigorous RCT globally, semaglutide 2.4 mg is of landmark significance and provides strong clinical evidence for the treatment of patients with CVD and overweight or obesity.</p><p>GLP-1RAs with proven cardiovascular benefits have been recommended by the guidelines as a first-line treatment for cardiovascular risk reduction in patients with T2DM and CVD or at high cardiovascular risk.<span>³⁰</span> The SELECT further provided evidence for the use of high-dose GLP-1RA in a broader population of patients with overweight or obesity and CVD without T2DM.</p><p>CVD remains the principal cause of mortality both in China and globally. Overweight and obesity are not only significant risk factors for CVD but also as an independent chronic disease. With societal economic progress and lifestyle alterations, overweight and obesity have increasingly emerged as major societal concerns. Effective weight management necessitates a multidisciplinary, multilevel, and long-term comprehensive strategy that incorporates political, economic, environmental, social, and personal factors. Presently, the availability of new management options for obesity and CVD is expanding, and it is expected that these evidence-based treatments will overcome current clinical challenges, thereby better fulfilling the demands of clinical care.</p><p>QP made substantial contributions to the design of the study and drafted the manuscript. SF and TX calibrated the format and language of the article, while LG critically reviewed the manuscript. All authors have read and approved the final version to be published.</p><p>The study was supported by National High Level Hospital Clinical Research Funding (BJ-2022-195).</p><p>The authors declare that they have no competing interests.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"272-275"},"PeriodicalIF":2.2,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12300","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in gynecological cancer incidence, mortality, and survival among elderly women: A SEER study","authors":"Subhadra Priyadarshini,&nbsp;Prafulla Kumar Swain,&nbsp;Khushi Agarwal,&nbsp;Diptismita Jena,&nbsp;Sourav Padhee","doi":"10.1002/agm2.12297","DOIUrl":"https://doi.org/10.1002/agm2.12297","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This paper aims to comprehensively analyze trends in gynecological cancers among elderly women in the United States from 1975 to 2020.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Surveillance, Epidemiology, and End Results (SEER) population data were utilized for the analysis. Annual Percentage Change (APC) and Average APC were estimated using join-point regression to assess trends in mortality rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study reveals an increasing pattern of incidence and mortality in all gynaecological cancer sites except cervical cancer among elderly. The incidence of cervical cancer decreased from 1975 to 2007 and then increased, whereas cancer-specific mortality decreased from 1977 to 2020, indicating positive advancements in detection and treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Despite progress in managing certain gynecological cancers, challenges persist, particularly evidenced by increasing mortality rates for cancers in other female genital organs. This underscores the necessity for sustained research efforts and targeted interventions to address these ongoing challenges effectively.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 2","pages":"179-188"},"PeriodicalIF":0.0,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12297","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140880921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between low handgrip strength and incontinence among Chinese middle-aged and older people: A cross-sectional study","authors":"Lin Li,&nbsp;Feilong Chen,&nbsp;Xiaoyan Li,&nbsp;Yiyuan Gao,&nbsp;Ning Wang,&nbsp;Tao Xu","doi":"10.1002/agm2.12309","DOIUrl":"10.1002/agm2.12309","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Incontinence seriously affects the lives of middle-aged and older people. Pelvic floor muscle assessment is very important for incontinence, and handgrip strength can be used as an auxiliary diagnostic tool. Our study aims to find new cutoff points of handgrip strength as early indicators of incontinence and analyze the association between low handgrip strength and incontinence among Chinese middle-aged and older people.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants were recruited from the 2015 China Health and Retirement Longevity Study. Receiver operating characteristic (ROC) curves were used to find the handgrip strength cutoff point. Logistic regression analysis was performed to explore other incontinence-related risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study included 10,229 middle-aged and older people. Compared with normal handgrip strength participants, medium strength participants had 1.510 [men, 95% confidence interval (CI) = 1.017–2.243] and 1.792 (women, 95% CI = 1.294–2.480) times greater risk of incontinence, and low strength participants had 2.420 (men, 95% CI = 1.787–3.277) and 1.516 (women, 95% CI = 1.130–2.032) times greater risk of incontinence. Trend test results showed that the risk of incontinence increased with decreasing handgrip strength in middle-aged and older people.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study suggests that handgrip strength &lt; 31 kg in men and &lt; 20.5 kg in women is significantly associated with higher risk of incontinence in Chinese middle-aged and older people. The risk of incontinence increases with decreasing handgrip strength. Handgrip strength should be measured in routine physical examinations in middle-aged and older people for timely assessment and intervention in incontinence.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"360-367"},"PeriodicalIF":2.2,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12309","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140656240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confronting health disparities: Lessons from the USA","authors":"Liming Zhang,&nbsp;Zhenyu Sun,&nbsp;Xueqing Jia,&nbsp;Ciyun Zhao,&nbsp;Jiening Yu,&nbsp;Xinwei Lyu,&nbsp;Joseph Tak Fai Lau,&nbsp;Na Li,&nbsp;Dongfu Qian,&nbsp;Zhihui Wang,&nbsp;Xi Chen,&nbsp;Zuyun Liu","doi":"10.1002/agm2.12303","DOIUrl":"10.1002/agm2.12303","url":null,"abstract":"&lt;p&gt;Reducing health disparities, generically referring to any measurable aspect of health that varies across individuals or social groups, has been positioned as a cornerstone of health care improvement and a priority for safety. Disparities in mortality, a fundamental manifestation of health inequality, pose complex challenges to the USA and China,&lt;span&gt;&lt;sup&gt;1-3&lt;/sup&gt;&lt;/span&gt; two of the largest health systems worldwide. In the USA, mortality disparities substantially exist across races, locations, and causes of death. Similarly, in China, these disparities are critical and vary remarkably across different sociodemographic contexts. The observed health disparities could be attributed to multiple determinants,&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; such as health care access, socioeconomic status, and environmental exposure. Identifying disparities through a sophisticated surveillance system for incident diseases and mortality and deciphering potential causes are indispensable prerequisites for promoting health equity.&lt;/p&gt;&lt;p&gt;In a recent issue of the &lt;i&gt;Lancet&lt;/i&gt;, the GBD US Health Disparities Collaborators conducted a county-level time-series analysis of racial-ethnic disparities in mortality in the USA.&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt; Utilizing the unique data acquired from the US National Vital Statistics death certificates and the US National Center for Health Statistics, the authors estimated age-standardized mortality from 2000 to 2019 by racial-ethnic group and county, describing the intersections between racial-ethnic and location-based disparities in mortality. The findings offer insights for future actions. First, they elucidated the temporal dynamic transitions of all-cause and cause-specific mortality in about two decades, providing a holistic insight into the evolving landscape of the mortality spectrum. This facilitates policymakers in navigating transitions in the primary goals of economic and health care policies with greater precision. Second, the non-Latino and non-Hispanic American Indian or Alaska Native (AIAN) and Black populations manifested higher mortality than the White populations across most causes of morbidity, which was attributable to the role of systemic racism on health and an increased risk of premature death. This racial disparity is evident in the socioeconomic status of minoritized individuals and populations. It is also reflected through various pathways, such as residential segregation, high rate of incarceration, chronic stress, and discrimination in health care, among other factors. In contrast, the Asian and Latino populations had lower mortality rates across most causes than the other racial-ethnic groups. It is well known that the USA stands as a prominent destination for immigrants, solidifying its position as one of the world's largest immigrant nations. With a staggering population of over 45 million foreign-born individuals, immigrants constitute a significant 13.6% of the country's total population. Undeniably, the Asian i","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 2","pages":"158-161"},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12303","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140689119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between frailty and inappropriate prescribing in elderly patients admitted to an Acute Care of the Elderly Unit","authors":"Mónica Zuleta,&nbsp;Inés Gozalo,&nbsp;Margarita Sánchez-Arcilla,&nbsp;Jordi Ibáñez,&nbsp;Carmen Pérez-Bocanegra,&nbsp;Antonio San-José","doi":"10.1002/agm2.12304","DOIUrl":"10.1002/agm2.12304","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim of this study is to analyze the association between the degree of frailty and inappropriate prescribing patterns at admission to an Acute Care of the Elderly Unit (ACE Unit).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Prospective observational study conducted in the ACE Unit of an acute hospital in Barcelona city between June and August 2021. Epidemiological and demographic data were collected during hospitalization. Comprehensive geriatric assessment was performed on admitted patients. We recorded frailty (FRAIL scale), extreme polypharmacy (10 or more drugs), central nervous system potentially inappropriate medications-PIMs (STOPP-CNS or group D), cardiovascular potential prescribing omissions-PPOs (START-CV or group A), and anticholinergic burden using the drug burden index (DBI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Ninety-three patients were included, of whom 48 (51.6%) were male, with a mean age of 82.83 (SD 7.53) years. The main diagnosis upon admission was heart failure in 34 patients (36.6%). Frail patients were older, with more dependence of activities of daily living and more comorbidity than non-frail patients. Additionally, frail patients demonstrated more omissions according to the START-A criteria. No statistically significant differences were observed in term of extreme polypharmacy, PIMs, or anticholinergic burden.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In the current study we found an association between frailty and inappropriate prescribing, specifically with regard to omissions using the START criteria for the cardiovascular system (group A). Notably, frail patients exhibited more omissions compared to their non-frail counterparts, and this difference was statistically significant.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 5","pages":"553-558"},"PeriodicalIF":2.2,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12304","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140695347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor neoantigens and tumor immunotherapies","authors":"Wang Jiani,&nbsp;Tan Qin,&nbsp;Ma Jie","doi":"10.1002/agm2.12295","DOIUrl":"10.1002/agm2.12295","url":null,"abstract":"<p>As a high-risk group of patients with cancer, the elderly exhibit limited efficacy with traditional treatments. Immunotherapy emerges as a promising adjunctive therapeutic approach that holds potential in addressing the needs of geriatric patients with cancer. Neoantigens, a unique class of tumor-specific antigens generated by non-synonymous mutations, are garnering increasing attention as targets for immunotherapy in clinical applications. Newly developed technologies, such as second-generation gene sequencing and mass spectrometry, have provided powerful technical support for the identification and prediction of neoantigens. At present, neoantigen-based immunotherapy has been extensively applied in clinical trials and has demonstrated both safety and efficacy, marking the beginning of a new era for cancer immunotherapy. This article reviews the conception, classification, inducers, and screening process of tumor neoantigens, as well as the application prospects and combination therapy strategies of neoantigen-based cancer immunotherapy.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 2","pages":"224-230"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12295","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140710012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The long-term effects of childhood circumstances on older individuals: A systematic review","authors":"Mst. Rina Parvin,&nbsp;Fateha Tuj Johra,&nbsp;Fazila Akter,&nbsp;Md. Wahiduzzaman,&nbsp;Khadiza Akter,&nbsp;Mousumi Das,&nbsp;Sujit Mondal,&nbsp;Mitun Debnath,&nbsp;Mohammad Ullah,&nbsp;Moustaq Karim Khan Rony","doi":"10.1002/agm2.12299","DOIUrl":"10.1002/agm2.12299","url":null,"abstract":"<p>Childhood experiences are known to shape individuals' development and can influence various aspects of life later on. Understanding the long-term effects is crucial for informing interventions and policies aimed at promoting healthy aging. This review aimed to explore the long-term effects of childhood experiences on older individuals. This systematic review comprised three distinct phases. Firstly, a systematic review was conducted, exploring databases such as Google Scholar, PubMed, EMBASE, PsycINFO, and the Web of Science. Out of the 2116 studies initially identified, 24 studies were selected based on the inclusion criteria. Secondly, these inclusion criteria were applied to ensure that the chosen studies specifically delved into the connection between childhood experiences and outcomes in older individuals. Finally, data extraction and synthesis techniques were employed to analyze findings, facilitating the drawing of conclusions concerning the enduring impacts of childhood experiences on the well-being of older individuals. The review's findings revealed how negative experiences in childhood continue to affect older individuals in various ways. These early-life events have far-reaching consequences, profoundly impacting their physical health, making them more susceptible to chronic diseases and weakening their immune system. Additionally, they affect mental health, leading to conditions like depression, anxiety, and substance abuse. Cognitive function is also affected, resulting in memory problems and cognitive decline. Furthermore, these experiences impact social relationships, affecting trust, emotional control, and social isolation in later life. This review highlighted the enduring influence of childhood circumstances on the health and well-being of older individuals. Policymakers and health care practitioners should consider these findings when developing strategies to support healthy aging and mitigate the long-term effects of adverse childhood experiences.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 2","pages":"239-251"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12299","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140708848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese expert consensus on diagnosis and management of gastroesophageal reflux disease in the elderly (2023)","authors":"Liu Fangxu,&nbsp;Li Wenbin,&nbsp;Zhang Pan,&nbsp;Chen Dan,&nbsp;Wu Xi,&nbsp;Xu Xue,&nbsp;Shi Jihua,&nbsp;Luo Qingfeng,&nbsp;Xu Le,&nbsp;Zheng Songbai,&nbsp;Chinese Geriatrics Society","doi":"10.1002/agm2.12293","DOIUrl":"https://doi.org/10.1002/agm2.12293","url":null,"abstract":"<p>Gastroesophageal reflux disease (GERD) in the elderly is characterized by atypical symptoms, relatively severe esophageal injury, and more complications, and when GERD is treated, it is also necessary to fully consider the general health condition of the elderly patients. This consensus summarized the epidemiology, pathogenesis, clinical manifestations, and diagnosis and treatment characteristics of GERD in the elderly, and provided relevant recommendations, providing guidance for medical personnel to correctly understand and standardize the diagnosis and treatment of GERD in the elderly.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 2","pages":"143-157"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12293","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140881105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scenario of unhealthy life cycle: The role of circadian rhythms in health","authors":"Manasa Chandramouli,&nbsp;Vrushabendra Basavanna,&nbsp;Srikantamurthy Ningaiah","doi":"10.1002/agm2.12301","DOIUrl":"10.1002/agm2.12301","url":null,"abstract":"<p>Circadian rhythms are oscillations in physiology and behavior caused by the circadian regulator. Cryptochromes, Periods, and Bmal1 are circadian clock genes that have been linked to aging and cancer. Human pathologies alter circadian clock gene expression, and transgenic rats with clock gene defects progress to cancer and age prematurely. In the growth of age-linked pathologies and carcinogenesis, cell proliferation and genome integrity play critical roles. The relationship concerning the cell cycle regulation and circadian clock is discussed in this article. The circadian clock controls the behavior and countenance of many main cell cycle and cell cycle check-point proteins, and cell cycle-associated proteins, in turn, control the activity and expression of circadian clock proteins. The circadian clock can be reset by DNA disruption, providing a molecular mechanism for mutual control amid the cell cycle and the clock. This circadian clock-dependent regulation of cell proliferation, composed with other circadian clock-dependent physiological functions including metabolism control, genotoxic and oxidative stress response, and DNA repair, unlocks new avenues for studying the processes of aging and carcinogenesis.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 2","pages":"231-238"},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12301","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140724968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}