Aging Medicine最新文献

{"title":"Research Progress on Idebenone in Neurodegenerative Diseases.","authors":"Yanqing Zhang, Yanhong Ren, Xiaoran Zhu, Tianhao Liu, Rundong Han, Yuqing Fang, Zhangning Zhao, Fei Mao, Yalin Wang, Xian Li, Xiuhua Li","doi":"10.1002/agm2.70047","DOIUrl":"10.1002/agm2.70047","url":null,"abstract":"<p><p>In recent years, significant progress has been made in understanding the therapeutic potential of idebenone (IDE), a synthetic analogue of Coenzyme Q10, in neurodegenerative diseases (NDs). This review comprehensively examines the pharmacological properties of IDE and its emerging applications in various NDs, with particular emphasis on Alzheimer's disease, Parkinson's disease, Friedreich's ataxia, and Huntington's disease. We elucidate IDE's multifaceted neuroprotective mechanisms, including its potent antioxidant activity that reduces reactive oxygen species production, its ability to enhance mitochondrial bioenergetics, and its regulatory effects on cellular metabolism. Additionally, we critically evaluate current clinical research findings and discuss the translational potential of IDE in ND therapeutics. The accumulated evidence strongly supports IDE as a promising mitochondrial-targeted agent capable of mitigating disease symptoms and modifying disease progression in multiple neurodegenerative disorders. This review highlights both the current achievements and future directions for IDE-based interventions in ND treatment.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 6","pages":"624-633"},"PeriodicalIF":2.5,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12793061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualization of OPN-Targeted Self-Assembled Micelles Encapsulated With an SIRT6 Activator and Doped Indocyanine Green for Attenuating Vascular Aging","authors":"Yan Fang,&nbsp;Wenyue Li,&nbsp;Cheng Qin,&nbsp;Mengqi Xu,&nbsp;Naiyuan Sun,&nbsp;Tingting Lu,&nbsp;Zhiyi Fang,&nbsp;Yan Ma,&nbsp;Linghuan Wang,&nbsp;Sulei Li,&nbsp;Xiaojing Wan,&nbsp;Hui Li,&nbsp;Renzheng Chen,&nbsp;Xiaoying Shen,&nbsp;Lei Tian,&nbsp;Jing Liu,&nbsp;Yi Hou,&nbsp;Feng Cao","doi":"10.1002/agm2.70045","DOIUrl":"https://doi.org/10.1002/agm2.70045","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objectives&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Sirtuin 6 (SIRT6) is a longevity-associated gene with recognized therapeutic potential for vascular aging through the regulation of vascular smooth muscle cells (VSMCs) senescence. This study aims to develop a visualized nanodelivery system for a SIRT6 activator to attenuate vascular aging in a mouse model.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The expression of the vascular aging marker, osteopontin (OPN), was detected by Western blot and histological staining in the aortas of naturally aging C57BL/6 mice. The SIRT6 activator MDL800 and the near-infrared (NIR) agent indocyanine green (ICG) were encapsulated by poly(caprolactone)–poly(ethylene glycol) (PCL-PEG), which was modified with OPN-targeting peptides, to construct OPN-targeting micelles loaded with MDL800 and ICG (OPN-MI). Particle size and zeta potential were assessed using transmission electron microscopy (TEM) and dynamic light scattering (DLS). The biocompatibility and in vitro NIR signals were evaluated in senescent VSMCs. NIR fluorescence imaging was then performed to visualize the temporal variation and biodistribution of OPN-MI micelles in aging vessels. After 8 weeks of intravenous injection into naturally aging mice, bioinformatics analysis, pulse wave velocity (PWV) measurement, pathological staining, and molecular biological experiments were conducted to explore the anti-aging mechanism of OPN-MI micelles.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The expression of OPN in the aortas of naturally aging mice was significantly higher than that in control mice (&lt;i&gt;p&lt;/i&gt; &lt; 0.001), confirming OPN as a target for vascular aging. The OPN-MI micelles exhibited a particle size of 107.008 ± 9.572 nm and a zeta potential of −7.293 ± 2.291 mV. These micelles demonstrated excellent biocompatibility, and their strength of NIR fluorescence signals increased proportionally with the concentration of OPN-MI micelles. In vivo and ex vivo NIR fluorescence imaging revealed that OPN-MI micelles accumulated significantly in the arterial walls of aged mice compared to MI micelles (&lt;i&gt;p&lt;/i&gt; &lt; 0.001). Bioinformatics analysis and validation showed that MDL800 reduced MMP9 expression by activating SIRT6 to deacetylate H3K9ac and H3K56ac. After 8 weeks of injection, the PWV of abdominal aortas in the OPN-MI micelles group decreased (&lt;i&gt;p&lt;/i&gt; = 0.031), the number of elastin breaks in the OPN-MI micelles group was reduced (&lt;i&gt;p&lt;/i&gt; = 0.016), and the intimal-medial thickness in the OPN-MI micelles group was alleviated (&lt;i&gt;p&lt;/i&gt; = 0.048) compared to the aged group. Mechanistically, OPN-MI micelles reduced MMP9 expression (&lt;i&gt;p&lt;/i&gt; = 0.001) through SIRT6 d","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 5","pages":"383-397"},"PeriodicalIF":2.5,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145399052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental Health and Aging: Identifying Risk and Protective Factors of Anxiety and Depression in Older Women","authors":"Guilherme Augusto Santos Bueno,&nbsp;Renato Canevari Dutra da Silva,&nbsp;Elton Brás Camargo Júnior,&nbsp;Stephany Kindorly de Oliveira Bueno,&nbsp;Anabela Correia Martins,&nbsp;Ruth Losada de Menezes","doi":"10.1002/agm2.70046","DOIUrl":"https://doi.org/10.1002/agm2.70046","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To identify risk and protective factors associated with anxiety and depression symptoms in older adult women, considering clinical, functional, and electrophysiological parameters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional observational study involved 91 women aged 65 or older. Assessments included EEG-derived valence and excitation levels, motor reaction time, body composition, and functional performance. Anxiety and depression were screened using the mind over mood anxiety inventory and the geriatric depression scale, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Anxiety symptoms were present in 28.6% of participants and depressive symptoms in 27.5%. Risk factors for anxiety included fear of falling (OR = 2.023, 95% CI = 1.554–2.944, <i>p</i> = 0.007), presence of depressive symptoms (OR = 2.254, 95% CI = 1.983–3.085, <i>p</i> = 0.008), and body fat percentage (OR = 1.543, 95% CI = 1.253–3.111, <i>p</i> = 0.011). Protective factors included valence (OR = 0.311, 95% CI = 0.272–0.544, <i>p</i> = 0.003), gait speed (OR = 0.674, 95% CI = 0.482–0.782, <i>p</i> = 0.023), and maximal expiratory pressure (OR = 0.755, 95% CI = 0.693–0.823, <i>p</i> = 0.027). For depressive symptoms, risk factors included fear of falling (OR = 1.983, 95% CI = 1.865<i>–</i>3.801, <i>p</i> = 0.023) and anxiety symptoms (OR = 1.765, 95% CI = 1.563–1.983, <i>p</i> = 0.008), while protective factors were cortical excitation (OR = 0.523, 95% CI = 0.425–0.693, <i>p</i> = 0.023) and expiratory pressure (OR = 0.635, 95% CI = 0.491–0.723, <i>p</i> = 0.021).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Functional and emotional parameters, particularly valence and gait performance, suggest a potential protective role against anxiety and depression in aging women. The findings reinforce the importance of integrated assessments to support early detection and guide intervention planning, while further studies are recommended to strengthen these observations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 5","pages":"412-422"},"PeriodicalIF":2.5,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145399083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in Medication Management for Older Adults in Low- and Middle-Income Countries: A Narrative Review","authors":"Christina Malini Christopher,&nbsp;Nabin Pathak,&nbsp;Zaheer-Ud-Din Babar,&nbsp;Sunil Shrestha","doi":"10.1002/agm2.70051","DOIUrl":"https://doi.org/10.1002/agm2.70051","url":null,"abstract":"<p>Artificial Intelligence (AI) has emerged as a transformative tool in medication management, particularly for older adults who are vulnerable to adverse drug events, polypharmacy, and medication non-adherence. This narrative review explores the utilization of AI-driven interventions in low and middle-income countries (LMICs) to enhance medication safety, adherence, and prescribing practices. The review synthesizes existing studies on AI applications, including automated drug interaction detection, machine learning models for adverse event prediction, and AI-supported decision-making tools for healthcare professionals. Findings suggest that AI has demonstrated significant potential in reducing inappropriate medication use and improving patient adherence through mobile applications and electronic health record (EHR) integration. However, AI adoption in LMICs remains limited despite its benefits due to high implementation costs, insufficient digital infrastructure, low AI literacy among healthcare providers, and ethical concerns related to data privacy and algorithm bias. Addressing these barriers requires strategic policy reforms, investment in AI education, and improved regulatory frameworks to ensure responsible and equitable AI deployment. Future research should focus on evaluating the long-term effectiveness of AI interventions in real-world settings and developing scalable solutions tailored to LMICs. With the right support, AI has the potential to revolutionize medication management, improving the quality of care and health outcomes for older adults globally.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 5","pages":"458-467"},"PeriodicalIF":2.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145398926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body Mass Index as a Potential Mediator of the Association Between Gout and Hypertension Among Chinese Older Adults: A Mediation Analysis in a Cross-Sectional Study","authors":"Jia Wang,&nbsp;Jian-bo Zhan,&nbsp;Lei Yi,&nbsp;Can Mei,&nbsp;Lin-wanyue Chen,&nbsp;Gui-ping Wang,&nbsp;Zi-jun Shi,&nbsp;Wei-ji Zhou,&nbsp;Chang-e Xiong,&nbsp;Jing Cheng","doi":"10.1002/agm2.70049","DOIUrl":"https://doi.org/10.1002/agm2.70049","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to investigate the role of the body mass index (BMI) as a mediator between gout and hypertension in older adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 33,778 older adults (aged 65 years and over) in Wuhan, China, were surveyed. The propensity score matching (PSM) method was used to control for confounding factors, and logistic regression was performed on the above three variables using the mediation package in the R language program.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The PSM method successfully matched 14,717 pairs. Mediation analysis revealed that, when controlling for the mediating variable “BMI”, the association coefficients of the independent variable “gout” on the dependent variable “hypertension” and of the mediating variable were statistically significant. This indicates the existence of a mediating association. Bootstrapping was used to quantify the stability of the observed indirect association, but temporal precedence or causality could not be established in this cross-sectional study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Gout is associated with hypertension, both directly and indirectly through BMI-related pathways. Therefore, monitoring and controlling the BMI of elderly gout patients to improve the progression of hypertension is of great significance.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 5","pages":"434-446"},"PeriodicalIF":2.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145398925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Outcomes in Pancreaticoduodenectomy for Elderly Patients Aged 80 and Above: A Retrospective Study Using Inverse Probability of Treatment Weighting","authors":"Tianxiao Wang,&nbsp;Yue Qiu,&nbsp;Yingjixing Luo,&nbsp;Ruili Wei,&nbsp;Li Xu,&nbsp;Jia Huang,&nbsp;Wenying Zhou,&nbsp;Hanchun Huang,&nbsp;Yongliang Sun,&nbsp;Zhiying Yang","doi":"10.1002/agm2.70048","DOIUrl":"https://doi.org/10.1002/agm2.70048","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>With an aging population, more elderly individuals are facing the decision to undergo complex surgeries, such as pancreaticoduodenectomy (PD). This study evaluates the safety and feasibility of PD in patients aged 80 and above.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective analysis of 422 patients who underwent PD between August 2011 and January 2024. The patients were categorized into three age groups: &lt; 60 years, 60–79 years, and ≥ 80 years. We adjusted for baseline characteristics using inverse probability of treatment weighting (IPTW) and compared postoperative complications, hospital stay durations, 90-day mortality, and long-term survival across the groups. A subgroup analysis identified factors associated with complications and 90-day mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After IPTW adjustment, no significant differences in complications or long-term survival were observed between the groups. However, the ≥ 80-year group had a significantly higher 90-day mortality rate (13.64%) compared to the 60–79 years group (2.00%) and the &lt; 60 years group (1.46%) (<i>p</i> = 0.002). Subgroup analysis identified hypertension, coronary artery disease (CAD), and nutritional risk (NRS ≥ 3) as independent risk factors for complications, while age ≥ 80 and CAD were associated with higher 90-day mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Age does not significantly impact postoperative complications or long-term survival following PD. While PD is safe and feasible for the elderly, those with cardiovascular comorbidities or poor nutritional status face higher risks of complications and mortality. A comprehensive preoperative assessment is critical to minimizing these risks.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 5","pages":"447-457"},"PeriodicalIF":2.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145398924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Frailty in Primary Care","authors":"Duncan Forsyth","doi":"10.1002/agm2.70050","DOIUrl":"https://doi.org/10.1002/agm2.70050","url":null,"abstract":"&lt;p&gt;As populations age, while those aged 65 years can expect to live on average around half of their remaining life expectancy in good health, the likelihood of their being disabled and/or experiencing multiple chronic and complex health conditions increases with advancing age. Thus, as life expectancy increases, so does the amount of time spent in poor health, which means the number of people living with complex and multiple conditions will also increase [&lt;span&gt;1&lt;/span&gt;]. Those living in deprived areas or experiencing poverty throughout life are more likely to develop frailty earlier than those from wealthier backgrounds [&lt;span&gt;2&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Although the risk of becoming frail increases with advancing age, frailty is not an inevitable consequence of aging, nor is it confined to the older population [&lt;span&gt;3&lt;/span&gt;]. Rockwood [&lt;span&gt;4&lt;/span&gt;] defined frailty as “a failure to integrate responses in the face of stress. This is why diseases manifest themselves as the “geriatric giants”….functions …such as staying upright, maintaining balance and walking are more likely to fail, resulting in falls, immobility or delirium”; in other words, frailty equates to poor functional and often cognitive reserve and is more related to biological than chronological age. The “geriatric giants,” also known as the 4 “I's: falls (instability), confusion (intellectual failure), immobility, and incontinence; to which might be added iatrogenic disease; may present as any combination of falls, confusion, immobility, and incontinence.” Particularly good markers of frailty are falls and delirium. Frailty is common, affecting approximately 10% of those aged over 65 years and 25%–50% of those aged over 85 years [&lt;span&gt;5&lt;/span&gt;] and leads to a higher risk of sudden deterioration in physical and mental health, often precipitated by a relatively minor event [&lt;span&gt;5&lt;/span&gt;] with a higher risk of mortality [&lt;span&gt;6&lt;/span&gt;]; and is distinct from living with one or more long-term conditions. Around 47% of hospital inpatients over 65 are affected by frailty [&lt;span&gt;7&lt;/span&gt;]; clinical frailty score [&lt;span&gt;8&lt;/span&gt;] correlates with increased mortality rates, with a 25% increase in mortality risk for each point increase in clinical frailty score (CFS) [&lt;span&gt;9&lt;/span&gt;], and with increased length of hospital stay [&lt;span&gt;10&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;So, as there is a risk of significant harm to those who are frail (those with complex needs), if healthcare systems and interventions are planned without consideration of their frailty, the purpose of screening for frailty is to identify: those at risk; what their risks are; and to implement what is necessary to minimize these risks, in order to reduce the risk of harm. That is, to do more good than harm! As complex frail older people have become major consumers of healthcare, there is a need for healthcare systems to move from single-condition disease-oriented care to individualized goal-oriented coordinated care and support; doing so should benefit ","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 5","pages":"379-382"},"PeriodicalIF":2.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145398919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mechanism and Potential Therapeutic Strategies of Vascular Aging","authors":"Wan-Zhou Wu,&nbsp;Xuan Wang,&nbsp;Fang-Fang Wu,&nbsp;Xiao-Tian Yan,&nbsp;Yong-Ping Bai","doi":"10.1002/agm2.70043","DOIUrl":"https://doi.org/10.1002/agm2.70043","url":null,"abstract":"<p>As we approach the mid-21st century, more developing countries are progressing towards becoming developed nations. Advances in medical technology have resulted in the prolonged human lifespan and a sustained decline in birth rates, leading to a growing proportion of the population being aged 65 and above. The aging process is associated with organ function deterioration, increased risks of age-related diseases, and a decrease in the quality of life for older adults. While there is ongoing debate about whether aging should be considered a disease or a natural physiological process, understanding the reasons for aging, identifying and measuring aging, and intervening in the aging process have become key topics in current medical research. Recent studies indicate that the rate of organ aging varies among individuals, with blood vessels being one of the organs that age first. Vascular aging increases the risk of cardiovascular diseases, overall mortality, and shortens lifespan. Therefore, in-depth research on vascular aging is crucial for understanding its impact on vascular and multi-organ function. In this review, we discuss the phenotypes caused by vascular aging, mechanisms of aging in various vascular cells, and potential therapeutic strategies for vascular aging.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 5","pages":"475-492"},"PeriodicalIF":2.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145398917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Technologies for Blood Glucose Management in Elderly Diabetics: An Interpretation of the Guidelines for the Management of Diabetes Mellitus in the Elderly in China (2024 Edition)","authors":"Qingyun Cai,&nbsp;Peiyi Zhao,&nbsp;Xinda Chen,&nbsp;Shuyi Yu,&nbsp;Lixin Guo,&nbsp;Qi Pan","doi":"10.1002/agm2.70044","DOIUrl":"https://doi.org/10.1002/agm2.70044","url":null,"abstract":"<p>The burden of diabetes in the elderly is becoming increasingly severe due to the aging population. Elderly patients with diabetes face unique challenges due to multiple comorbidities, atypical symptoms, an increased risk of hypoglycemia, and limited self-management capabilities. The <i>Guidelines for the Management of Diabetes Mellitus in the Elderly in China</i> (2024 Edition) advocate for a stratified, individualized approach that addresses the heterogeneous pathophysiologic profiles of these patients. Recent technological advances, including continuous glucose monitoring, smart insulin pens, needle-free injection systems, and new insulin pumps, have significantly improved glycemic management. The updated guidelines systematically review evidence-based recommendations for managing diabetes in the elderly, emphasizing the benefits of modern monitoring and insulin delivery technologies. This article interprets the updated guidelines with a focus on the technical principles, clinical benefits, and application dilemmas to ultimately improve long-term outcomes among elderly patients with diabetes.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 5","pages":"468-474"},"PeriodicalIF":2.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145398916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose–Response Associations of Grip Strength and Gait Speed With Multidimensional Mental Health","authors":"Jiapei Wei,&nbsp;Liming Zhang,&nbsp;Shengyi Li,&nbsp;Xucheng Wu,&nbsp;Xingqi Cao,&nbsp;Liying Chen,&nbsp;Zuyun Liu,&nbsp;Yangzhen Lu,&nbsp;Xuan Ge","doi":"10.1002/agm2.70042","DOIUrl":"https://doi.org/10.1002/agm2.70042","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>We aimed to examine the dose–response associations of grip strength and gait speed with multidimensional mental health among Chinese adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Cross-sectional data on 661 adults from the ZheJiang longitudinal Study of Healthy Aging (JASHA) were utilized. Grip strength and gait speed were measured during physical examinations. Multidimensional mental health, covering cognitive function (the Auditory Verbal Learning Test (AVLT), the Montreal Cognitive Assessment (MoCA) test, and the Digit Symbol Substitution Test (DSST)), depressive symptoms (the Center for Epidemiologic Studies Depression (CES-D) Scale), and psychological distress (the Perceived Stress Scale (PSS)), were assessed via standard questionnaires. Multivariable linear regression models and restricted cubic splines were applied to examine these associations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We found linear dose–response associations of grip strength and gait speed with most dimensions of mental health. For instance, higher grip strength was positively associated with higher cognitive function scores (AVLT_N3: <i>β</i> = 0.084, standard error (SE) = 0.032; DSST: <i>β</i> = 0.246, SE = 0.073 for per unit increase in grip strength) and lower CES-D scores (<i>β</i> = −1.265, SE = 0.626). Similarly, higher gait speed was associated with higher cognitive function scores (AVLT_N3: <i>β</i> = 2.882, SE = 0.860; MoCA: <i>β</i> = 0.996, SE = 0.499 for per unit increase in gait speed), lower CES-D scores (<i>β</i> = −1.448, SE = 0.692), and lower PSS scores (<i>β</i> = −2.808, SE = 0.938). Notably, the associations were more pronounced in females and older adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In this sample spanning a wide range of ages, we found linear significant associations of grip strength and gait speed with most dimensions of mental health. The finding unveils the intrinsic connections between musculoskeletal function and mental health, highlighting the potential of preserving musculoskeletal function, such as via maintaining regular physical exercise, to prevent mental health disorders, especially for females and older adults.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 5","pages":"423-433"},"PeriodicalIF":2.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145398918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}