Aging Medicine最新文献

{"title":"Logistic Regression and Machine Learning Algorithms for the Risk Prediction of Perioperative Adverse Cardiovascular Events in Elderly Patients","authors":"Xiao Yan Li, Guang You Duan, Lin Li, Yi Yuan Gao, Li Wen Sun, Silin Zhu, Xiyezi Diao, Ning Wang, He Huang","doi":"10.1002/agm2.70037","DOIUrl":"https://doi.org/10.1002/agm2.70037","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Elderly patients with perioperative adverse cardiovascular events (PACEs) may have poorer prognosis and higher mortality. Early identification of patients at risk of developing PACEs is an essential step in preventing and controlling PACEs. To develop and validate models to predict the likelihood of PACEs and to clarify the specific classification of PACEs with different risk stratification for the elderly patients during noncardiac surgery by integrating clinical data, biomarkers, and established risk factors. Most importantly, they help to support clinical decision making and improve patient prognosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included elderly in-patients undergoing noncardiac surgery at six hospitals in Chongqing City, China, from March 2020 to July 2021. Logistic regression and machine learning algorithms were used to construct models, which were evaluated by receiver operating characteristic curves, decision curve, calibration curve, sensitivity, specificity, and F1-score were used to interpret the model results. The diagnostic criteria for PACEs encompassed delirium, major adverse cardiovascular events, myocardial injury after noncardiac surgery, new perioperative atrial fibrillation, perioperative acute heart failure, pain and infection, and other cardiovascular events that pose a threat to perioperative safety and influence patient prognosis. PACEs were identified by expert anesthesiologists in accordance with ASA classification on the day preceding surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 8309 patients included in the analysis, 1805 were suspected of having PACEs. The logistic regression model was chosen with the area under the curve for 0.895 (95% CI: 0.881–0.908). Pro-BNP, cardiac function grading, and creatinine (Cre) were the most related factors for PACEs, and a new composite indicator PCC was developed by combining the initials of these three indicators in the logistic regression model. The decision curve and calibration curve indicated that this indicator had respectable clinical value. In addition, a machine learning model was built to accurately predict PACEs of different risk stratification in the elderly. Precision-recall curves of the prediction showed low-risk precision was 0.86, and medium-risk precision was 0.870, and high-risk precision was 0.970. The F1 values are all greater than 0.850, especially for the high risk, the prediction effect reaches 0.970. The sensitivity and specificity of the prediction model were 0.736 and 0.973, respectively, indicating that it had the best predictive performance of risk stratificati","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 5","pages":"398-411"},"PeriodicalIF":2.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145398906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generation of Nonintegrative-Induced Pluripotent Stem Cells in Hutchinson-Gilford Progeria Syndrome: Enhancing Aging Research","authors":"Juned Kadiwala,&nbsp;Rameen Shakur","doi":"10.1002/agm2.70041","DOIUrl":"https://doi.org/10.1002/agm2.70041","url":null,"abstract":"<p>Heart failure and cardiovascular disease are the primary causes of mortality in patients with Hutchinson-Gilford Progeria Syndrome (HGPS), resulting from mutations in the LMNA gene. In this study, we investigated a familial pedigree of HGPS to derive induced pluripotent stem (iPS) cells using a nonintegrating Sendai virus method from both affected and unaffected family members. The goal was to create a comprehensive robust and reliable cellar model to study the accelerated aging disease's progression. The resulting iPSCs fulfilled all pluripotency criteria, demonstrated differentiation into all three germ layers, and retained the HGPS mutation. In addition, these iPSCs exhibited key HGPS characteristics, such as shortened telomeres, abnormal Lamin A (Progerin) expression, and reduced cardiac marker levels. Thus, our approach offers a robust, reliable, and accurate representation of the disease pathology for the aging community.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 5","pages":"493-498"},"PeriodicalIF":2.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145399078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Turn Impairments and Cognitive Function in Parkinson Disease","authors":"Shanhu Xu,&nbsp;Linlin Kong,&nbsp;Xiaoli Liu,&nbsp;Yue Lou,&nbsp;Luyan Gu,&nbsp;Qiuhan Xu,&nbsp;Xun Tan,&nbsp;Jiali Pu,&nbsp;Baorong Zhang","doi":"10.1002/agm2.70033","DOIUrl":"https://doi.org/10.1002/agm2.70033","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the association of turn parameters with cognitive status in patients with Parkinson disease (PD) and determine the value of turn performance in distinguishing PD-related cognitive impairment (CI) from normal cognition (NC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study recruited 168 patients with PD, including 102 patients with NC and 66 patients with CI. The participants performed 180° turn performance trials during the Timed Up and Go walk and 360° turn trials in place using the MATRIX wearable system. Four turn parameters, namely, turn duration, step count, mean turn angular velocity (MAV), and peak turn angular velocity (PAV), were evaluated. Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) were performed to evaluate cognitive function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In comparison with the PD-NC group, the PD-CI group showed significantly higher turn duration and step counts and lower MAV and PAV during both 180° and 360° turns. The four turn parameters were significantly correlated with MMSE and MoCA scores after correction for age and educational level. Regression models suggested that the risk of PD-CI was associated with step counts and MAV during 360° turns. The area under the curve values of the step counts and MAV during 360° turns for distinguishing PD-CI from PD-NC were 0.781 and 0.789, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings indicate that turn performance is associated with cognitive status in patients with PD. Assessment of 360° turn characteristics during routine clinic visits would provide a better understanding of CI status in individuals with PD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 4","pages":"286-293"},"PeriodicalIF":2.5,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spino-Pelvic Alignment and Surgical Outcomes in Chinese Elderly With Lumbar Stenosis Syndrome: A Prospective Study","authors":"Chong Zhao,&nbsp;Linyu Jin,&nbsp;Yan Liang,&nbsp;Haiying Liu,&nbsp;Shuai Xu","doi":"10.1002/agm2.70036","DOIUrl":"https://doi.org/10.1002/agm2.70036","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to systematically identify and quantify the acceptable spino-pelvic parameters for Chinese elderly patients with lumbar stenosis syndrome (LSS) following surgical treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>A prospective study of 165 LSS cases from July 2018 to June 2020 evaluated spino-pelvic alignment using PI, LL, PT, and SVA, categorized by SRS-Schwab classification. Quality of life was assessed via the Oswestry disability index (ODI), and parameter thresholds were determined by AICc and ROC analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No significant change in radiological parameters was observed postsurgery. However, clinical outcomes improved with lower grades of PI-LL and PT. The mean threshold for PI-LL and PT at baseline was 18.8° and 26.1°, respectively. At the endpoint, PI-LL was 17.7°, and PT was 26.1°, indicating optimal ranges for surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Spino-pelvic alignment significantly correlates with quality of life in elderly LSS patients. The study suggests that PI-LL and PT should be maintained within 17.7° and 26.1°, respectively, for optimal surgical outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 4","pages":"347-355"},"PeriodicalIF":2.5,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potentially Inappropriate Medications and Drug–Drug Interactions in Geriatrics Cardiac Patients Visiting to Tertiary Care Central Hospital of Nepal","authors":"Roshan Giri,&nbsp;Rajeev Shrestha,&nbsp;Aatma Rai,&nbsp;Gobinda Kandel,&nbsp;Punam Gauchan,&nbsp;Parbati Thapa","doi":"10.1002/agm2.70034","DOIUrl":"https://doi.org/10.1002/agm2.70034","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Potentially Inappropriate Medications (PIMs) and Drug–Drug Interactions (DDIs) among geriatrics are a prominent issue and place a considerable burden on the quality health outcome. This study aimed to assess PIMs and DDIs particularly among geriatric cardiac elderly patients attending the outpatient department of a tertiary care hospital of Nepal.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methodology</h3>\u0000 \u0000 <p>A prospective cross-sectional study was conducted on geriatrics patients (≥ 65 years) attending the cardiology out-patient department of Bharatpur Central Hospital, Nepal. Beers criteria were used to assess PIM, and Medscape software was employed to assess DDIs. Regression analysis was performed to identify the predictors of PIM and DDIs experienced by patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 140 geriatric patients were enrolled in the study. A total of 683 drugs were prescribed to them, with an average of 4.59 medications per patient. 23.6% and 65% of patients were found to be prescribed PIMs and encountered DDIs, respectively. Proton Pump Inhibitors (PPI) (66.67%) were the most prescribed PIMs and involved in identified DDIs. The removal of PIMs was calculated to reduce 11.72% of the cost of patients prescribed PIMs and 19.88% of identified DDIs. The number of medications prescribed was found to be a significant predictor for PIM (Odd Ratio: 1.352) and DDIs (Odd Ratio: 2.217) encountered.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study highlights the concerning prevalence of potentially inappropriate medication and drug–drug interactions among ambulatory cardiac elderly patients. Integration of regular medication audits and evidence-based prescribing practices is essential to optimize pharmacological management and enhance patient safety.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 4","pages":"303-311"},"PeriodicalIF":2.5,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced Masseter Muscle Area Predicts the 6-Month Outcome After Mild Traumatic Brain Injury in Older Adults","authors":"Liang Wu,&nbsp;Yunfei Li,&nbsp;Meng Sun,&nbsp;Nanyu Yao,&nbsp;Zhaofeng Zhang,&nbsp;Weiming Liu","doi":"10.1002/agm2.70040","DOIUrl":"https://doi.org/10.1002/agm2.70040","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Mild traumatic brain injury (mTBI) in older patients is a common condition in neurosurgery, often linked to poor long-term outcomes, especially when accompanied by frailty. Sarcopenia contributes to this frailty and can be assessed through transverse imaging methods. This study aimed to assess the prognostic value of the masseter muscle cross-sectional area (MCSA) as determined from admission CT head scans in older patients with mTBI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study identified older patients with mTBI who were admitted to our hospital from April 2013 to December 2022. The Glasgow Outcome Scale Extended (GOSE) was utilized to assess neurological outcomes at 6 months follow-up, which were divided into complete recovery (GOSE = 8) and incomplete recovery (GOSE ≤ 7). We measured the average MCSA using admission CT scans and evaluated the consistency of these measurements. Multivariable logistic regression was conducted to evaluate the association between reduced MCSA and 6-month clinical outcomes in older mTBI patients while adjusting for age, gender, and comorbidity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study involved 227 patients, 135 (59.5%) males and 92 (40.5%) females, with a mean age of 74.1 years. 92 (40.5%) had an adverse clinical outcome by the end of follow-up. The intra- and inter-observer reliability of the MCSA measurements was good to excellent (ICCs = 0.955–0.972 and 0.856–0.892). MCSA decreased with age (Pearson's <i>r</i> = −0.290, <i>p</i> &lt; 0.001). Males had higher MCSA than females (<i>p</i> &lt; 0.001). The optimal MCSA cutoff values for predicting 6-month clinical outcomes were 358.75 mm² for male and 263.25 mm² for female patients. Reduced MCSA was associated with 6-month clinical outcomes in univariate and multivariate logistic analyses (OR = 0.131, 95% CI: 0.063–0.273; <i>p</i> &lt; 0.001). The MCSA was linearly associated with incomplete recovery (<i>p</i> &lt; 0.001, P for nonlinear = 0.127).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>MCSA measurements from initial scans were reliable, providing prognostic information that supplemented existing predictors of poor outcomes in older mTBI patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 4","pages":"294-302"},"PeriodicalIF":2.5,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Type 2 Diabetes Mellitus and Chronic Kidney Disease on Bone Mineral Density in Elderly Patients With Fragility Hip Fracture: A Cross-Sectional Study","authors":"Debajyoti Roy,&nbsp;Jiashen Cai,&nbsp;Chee Yong Ng,&nbsp;Sreekanth Koduri,&nbsp;Chang Yin Chionh,&nbsp;Rehena Sultana,&nbsp;Wenxiang Yeon","doi":"10.1002/agm2.70035","DOIUrl":"https://doi.org/10.1002/agm2.70035","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Diabetes mellitus (DM) and chronic kidney disease (CKD) are prevalent conditions in the elderly population, increasing the risk of bone fractures due to their adverse effects on bone quality. This study aimed to assess their impact on bone health and propose interventions to mitigate fracture risk in this demographic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study involving 571 elderly patients (aged ≥ 65 years) with fragility hip fractures was conducted at a tertiary care hospital between June 2014 and June 2016. Patients were categorized into four groups based on DM and CKD presence. Bone mineral density (BMD) at the femoral neck was measured using dual-energy X-ray absorptiometry (DXA) scan. Statistical analysis included ANOVA with Bonferroni correction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean age was 79.5 ± 7.3 years, with females comprising 70.6%. Group 2 (No CKD with diabetes) exhibited higher <i>T</i>-scores than Group 1 (No CKD or Diabetes). Patients with DM had higher <i>T</i>-scores, with an increase of 0.2 compared to those without DM and CKD. Surprisingly, CKD and DM coexistence (Group 4) did not worsen <i>T</i>-scores. Higher HbA1c levels were positively associated with a higher <i>T</i>-score, but this was lost in concurrent CKD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Patients with DM had higher <i>T</i>-scores; the combination of CKD and DM did not worsen <i>T</i>-scores. However, the positive association between higher HbA1c and higher <i>T</i>-score was nullified in concurrent CKD. These findings emphasize the need for tailored interventions to mitigate fracture risk in elderly populations with DM and CKD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 4","pages":"279-285"},"PeriodicalIF":2.5,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tendon Aging: A Silent Enemy Revealed Strategies for Effective Treatment","authors":"Wenhui Gu,&nbsp;Guohua Wang,&nbsp;Haifeng Zhang,&nbsp;Yinxian Yu","doi":"10.1002/agm2.70027","DOIUrl":"https://doi.org/10.1002/agm2.70027","url":null,"abstract":"<p>Tendons have a special makeup and set of physiological characteristics that make it difficult for them to mend themselves after damage. Aged tendons are more prone to injury, and wounded tendons will also age faster than usual. This creates a vicious cycle that might cause an injured tendon to reach surgery standards earlier than necessary or cause a re-injury after surgery. Nowadays, the utilization of appropriate medications and exercise is the mainstay of tendon aging treatment. Due to their high potential for differentiation, tendon stem/progenitor cells (TSPCs) have drawn the attention of an increasing number of studies. The mechanism of tendon aging is outlined in this review, along with how it is caused by oxidative stress, hyperglycemia, inflammation, cell apoptosis, fatty infiltration, and its relationship to TSPCs. The goal of this review was to investigate the mechanism of aging and identify related treatment strategies that can effectively prevent further deterioration, slow down tendon aging, and minimize the risk of tendon re-injury following surgery.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 4","pages":"356-369"},"PeriodicalIF":2.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitude, and Practice on Atrial Fibrillation and Atrial Fibrillation Screening in High-Risk Population: A Cross-Sectional Study","authors":"Zhong Yi,&nbsp;Xinxin Yan,&nbsp;Shaozhi Xi,&nbsp;Lijuan Zhu,&nbsp;Rui Liu,&nbsp;Jing Li,&nbsp;Songwei Ru,&nbsp;Xiu Zheng,&nbsp;Jingxuan Qiu,&nbsp;Chunqi Wang,&nbsp;Na Guo,&nbsp;Yimin Wang,&nbsp;Dayong Gao","doi":"10.1002/agm2.70030","DOIUrl":"https://doi.org/10.1002/agm2.70030","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Atrial fibrillation (AF) is a common clinical arrhythmia. Failure to identify AF leaves patients at a considerably higher risk of disability and death, making its early screening and prevention extremely important. This study aimed to investigate knowledge, attitude, and practice (KAP) towards AF prevention and screening among the high-risk population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Individuals at a high risk of AF were required to fill out questionnaires between August 2022 and October 2022.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 863 participants aged 66.54 ± 11.00 years were enrolled. The median scores of knowledge, attitude, and practice were 9 (81.8% of maximum), 37 (64.9% of maximum), and 21.56 (86.2% of maximum), respectively. Only knowledge (OR = 1.159, 95% confidence interval (CI): 1.045–1.286, <i>p</i> = 0.005) was independently associated with better practice, while attitude (OR = 0.861, 95% CI: 0.817–0.908, <i>p</i> &lt; 0.001), reported poor sleep quality (OR = 0.529, 95% CI: 0.259–1.0788, <i>p</i> = 0.010), fair (OR = 0.234, 95% CI: 0.111–0.491, <i>p</i> &lt; 0.001) or fluctuating (OR = 0.321, 95% CI: 0.103–0.996, <i>p</i> = 0.049) emotional state, and acquiring the questionnaire through social media (OR = 0.419, 95% CI: 0.268–0.653, <i>p</i> &lt; 0.001) were independently associated with worse practice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Participats from high-risk AF population in this study demonstrated acceptable practice towards AF screening, mostly moderated by knowledge and attitude. Some gaps in knowledge could be improved by targeted health education, especially important in vulnerable subpopulations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 4","pages":"312-323"},"PeriodicalIF":2.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Theoretical Hypothesis on Comorbidity in the Elderly—The Disease of Sympathetic Overdrive (DSO)","authors":"Li Jie,&nbsp;Kong Jian,&nbsp;Yu Boxin,&nbsp;Li Hongyang","doi":"10.1002/agm2.70026","DOIUrl":"https://doi.org/10.1002/agm2.70026","url":null,"abstract":"<p>The coexistence of multimorbidity and geriatric syndromes is a big character and role target to manage for the clinic works in older age, but related theories still require innovation and exploration. The disease of sympathetic overdrive (DSO) is a new hypothesis, a disease full of characteristics of organics and emotion, multiple systems, and lifestyle illness. The hypothesis of DSO might be able to explain and improve the theory about the coexistence of multimorbidity and geriatric syndromes and even more!.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"8 4","pages":"370-374"},"PeriodicalIF":2.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.70026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}