Aging Medicine最新文献

{"title":"Effects of a prior failed attempt on the outcomes of subsequent chronic total occlusion-percutaneous coronary intervention","authors":"Nai-Xin Zheng, Hu Ai, Ying Zhao, Hui Li, Guo-Jian Yang, Guo-Dong Tang, Xi Peng, Fu-Cheng Sun, Hui-Ping Zhang","doi":"10.1002/agm2.12350","DOIUrl":"10.1002/agm2.12350","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Patients undergoing a prior failed attempt of chronic total occlusion-percutaneous coronary intervention (CTO-PCI) represent a challenging subgroup across all patients undergoing CTO-PCI. There are limited data on the effects of a prior failed attempt on the outcomes of subsequent CTO-PCI. We aimed to compare the procedural results and 24-month outcomes of prior-failed-attempt CTO-PCI with those of initial-attempt CTO-PCI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients who underwent attempted CTO-PCI between January 2017 and December 2019 were prospectively enrolled. We analyzed the procedural results and 24-month major adverse cardiac events (MACE) between patients who underwent prior-failed-attempt and initial-attempt CTO-PCI. MACE was defined as a composite of cardiac death, target vessel-related myocardial infarction, and ischemia-driven target vessel revascularization (TVR) during follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 484 patients who underwent CTO-PCI (prior-failed-attempt, <i>n</i> = 49; initial-attempt, <i>n</i> = 435) were enrolled during the study period. After propensity score matching (1:3), 147 patients were included in the initial-attempt group. The proportion of the Japanese-CTO (J-CTO) score ≥2 was higher in the patients who underwent prior failed attempt than in those who underwent initial attempt (77.5% vs. 38.8%, <i>p</i> < 0.001). The retrograde approach was more often adopted in the prior-failed-attempt group than in the initial-attempt group (32.7% vs. 3.4%,  [<i>P</i>< 0.001). Successful CTO revascularization rates were significantly lower in the prior-failed attempt-group than in the initial attempt group (53.1% vs. 83.3%, <i>P</i> < 0.001). The multivariate analysis revealed that J-CTO score ≥2 [odds ratio (OR), 0.359; 95% confidence interval (CI), 0.159–0.812; <i>P</i> = 0.014], intravascular ultrasound procedure (OR, 4.640; 95% CI, 1.380–15.603; <i>P</i> = 0.013), and prior failed attempt (OR, 0.285; 95% CI, 0.125–0.648; <i>P</i> = 0.003) were the independent predictors for successful CTO revascularization. There were no significant differences in major procedural complications (2.0% vs. 0.7%, <i>p</i> = 0.438) and MACE rates (4.1% vs. 8.8%, <i>p</i> = 0.438) between the groups, mainly due to the TVR rate (4.1% vs. 8.2%, <i>P</i> = 0.522).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Compared with initial-attempt CTO-PCI, prior-failed-attempt CTO-PCI deserves more attention, since it is associated with a lower successful CTO revascu","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 4","pages":"463-471"},"PeriodicalIF":2.2,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11369334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and factors associated with low functional mobility in older adults","authors":"Fernanda Nascimento de Oliveira,&nbsp;Eduarda Pereira Damião,&nbsp;Lucas dos Santos,&nbsp;Lucas Lima Galvão,&nbsp;Helen Rocha Machado,&nbsp;Rizia Rocha Silva,&nbsp;Sheilla Tribess,&nbsp;Jair Sindra Virtuoso Júnior,&nbsp;Douglas de Assis Teles Santos","doi":"10.1002/agm2.12323","DOIUrl":"https://doi.org/10.1002/agm2.12323","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To analyze the factors associated with low functional mobility in older adults residing in Alcobaça, BA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is an epidemiological survey with a cross-sectional design, conducted in 2015 with 473 older adults (62.4% women; mean age 70.2 ± 8.2 years) from Alcobaça, BA. The interview script addressed sociodemographic characteristics, health, and behavioral aspects. Functional mobility was assessed using the Short Physical Performance Battery (≤6 points). Inferential analyses were conducted using the Mann–Whitney U test and Poisson regression (with robust variance and estimation of prevalence ratios and their respective 95.0% confidence intervals).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The prevalence of low functional mobility was 9.6%, with associated factors including the use of alcoholic beverages (PR = 1.7, 95% CI: 1.01–1.13) and the number of repetitions in elbow flexion (PR = 1.01, 95% CI: 1.01–1.05). Additionally, older adults with low mobility had lower height, thigh circumference, and lower performance in handgrip strength tests, elbow flexion, and flexibility. They also spent more time in sedentary behavior and less time in physical activity compared to older adults with preserved mobility (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Older adults with low mobility exhibit poorer values in anthropometric parameters, lower performance in motor tests, spend less time engaged in physical activities, and more time in sedentary behavior.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"292-300"},"PeriodicalIF":2.2,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12323","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced vasorin signaling mitigates adverse cardiovascular remodeling","authors":"Mingyi Wang,&nbsp;Kimberly Raginski McGraw,&nbsp;Robert E. Monticone,&nbsp;Roberta Giordo,&nbsp;Ali H. Eid,&nbsp;Gianfranco Pintus","doi":"10.1002/agm2.12332","DOIUrl":"https://doi.org/10.1002/agm2.12332","url":null,"abstract":"<p>Arterial stiffening is a critical risk factor contributing to the exponential rise in age-associated cardiovascular disease incidence. This process involves age-induced arterial proinflammation, collagen deposition, and calcification, which collectively contribute to arterial stiffening. The primary driver of proinflammatory processes leading to collagen deposition in the arterial wall is the transforming growth factor-beta1 (TGF-β1) signaling. Activation of this signaling is pivotal in driving vascular extracellular remodeling, eventually leading to arterial fibrosis and calcification. Interestingly, the glycosylated protein vasorin (VASN) physically interacts with TGF-β1, and functionally restraining its proinflammatory fibrotic signaling in arterial walls and vascular smooth muscle cells (VSMCs). Notably, as age advances, matrix metalloproteinase type II (MMP-2) is activated, which effectively cleaves VASN protein in both arterial walls and VSMCs. This age-associated/MMP-2-mediated decrease in VASN levels exacerbates TGF-β1 activation, amplifying arterial fibrosis and calcification in the arterial wall. Importantly, TGF-β1 is a downstream molecule of the angiotensin II (Ang II) signaling pathway in the arterial wall and VSMCs, which is modulated by VASN. Indeed, chronic administration of Ang II to young rats significantly activates MMP-2 and diminishes the VASN expression to levels comparable to untreated older control rats. This review highlights and discusses the role played by VASN in mitigating fibrosis and calcification by alleviating TGF-β1 activation and signaling in arterial walls and VSMCs. Understanding these molecular physical and functional interactions may pave the way for establishing VASN-based therapeutic strategies to counteract adverse age-associated cardiovascular remodeling, eventually reducing the risk of cardiovascular diseases.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"414-423"},"PeriodicalIF":2.2,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12332","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with cognitive function in patient with Alzheimer's disease with newly prescribed acetylcholinesterase inhibitors: A 1-year retrospective cohort study","authors":"Pao-Yuan Ching,&nbsp;Cheng-Ho Chang,&nbsp;Chih-Chuan Pan,&nbsp;Yung-Chih Chiang,&nbsp;Hsin-ya Kuo,&nbsp;Tien-Wei Hsu,&nbsp;Che-Sheng Chu","doi":"10.1002/agm2.12324","DOIUrl":"https://doi.org/10.1002/agm2.12324","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We aimed to examine the factors associated with treatment outcomes in patients with Alzheimer's disease (AD) after 1 year of acetylcholinesterase inhibitors (AChEI) treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>We obtained electronic medical records from a medical center in Southern Taiwan between January 2015 and September 2021. Participants aged ≥60 who were newly diagnosed with AD and had been prescribed AChEIs were included. Cognitive assessments were performed before the AChEIs were prescribed and at the 1 year follow-up. Cognition progressors were defined as a Mini-Mental State Examination decline of &gt;3 or a Clinical Dementia Rating decline of ≥1 after 1 year of AChEI treatment. The relationship between the baseline characteristics and cognitive status after follow-up was investigated using logistic regression analysis after adjusting for potential confounders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 1370 patients were included in our study (mean age, 79.86 ± 8.14 years). After adjustment, the body mass index (BMI) was found to be significantly lower in the progressor group [adjusted odds ratio (AOR): 0.970, 95% confidence intervals (95% CIs): 0.943 to 0.997, <i>P</i> = 0.033]. The usage of antipsychotics was significantly higher in the progressor group (AOR: 1.599, 95% CIs: 1.202 to 2.202, <i>P</i> = 0.001). The usage of benzodiazepine receptor agonists also tended to be significantly higher in the progressor group (AOR: 1.290, 95% CIs: 0.996 to 1.697, <i>p</i> = 0.054).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These results suggest that patients with AD who receive 1 year of AChEI treatment and have a lower BMI or concurrent treatment with antipsychotics and benzodiazepine receptor agonists are more likely to suffer from cognitive decline.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"312-319"},"PeriodicalIF":2.2,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12324","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulse field ablation for atrial fibrillation: Is the curtain about to rise?","authors":"Junpeng Liu,&nbsp;Min Dong,&nbsp;Jiefu Yang","doi":"10.1002/agm2.12326","DOIUrl":"https://doi.org/10.1002/agm2.12326","url":null,"abstract":"&lt;p&gt;Catheter ablation has been validated as an effective intervention for atrial fibrillation (AF) patients, significantly reducing recurrence rates, improving prognoses, and enhancing life quality.&lt;span&gt;&lt;sup&gt;1-3&lt;/sup&gt;&lt;/span&gt; However, conventional methods employing radiofrequency or cryothermal energy suffer from a lack of tissue specificity, potentially leading to complications such as pulmonary vein stenosis, atrioesophageal fistula, and hemidiaphragmatic paralysis.&lt;span&gt;&lt;sup&gt;2, 3&lt;/sup&gt;&lt;/span&gt; Pulsed field ablation (PFA) has recently emerged as a promising alternative, utilizing the microsecond-scale, high-voltage electrical fields to induce irreversible electroporation and cell membrane destabilization, culminating in cellular necrosis.&lt;span&gt;&lt;sup&gt;4, 5&lt;/sup&gt;&lt;/span&gt; Its superior tissue selectivity minimizes damage to non-target tissues during ablation, positioning PFA as an ideal modality for cardiac ablation.&lt;/p&gt;&lt;p&gt;Preclinical experiments utilizing animal models have underscored the potential of PFA for achieving durable pulmonary vein isolation (PVI),&lt;span&gt;&lt;sup&gt;6, 7&lt;/sup&gt;&lt;/span&gt; highlighting the method's capability to form comprehensive transmural lesions devoid of adverse effects like pulmonary vein ostia stenosis or esophageal damage.&lt;span&gt;&lt;sup&gt;8, 9&lt;/sup&gt;&lt;/span&gt; Notably, PFA's application has shown efficacy in permanently neutralizing the atrial ganglion plexus without compromising atrial myocardium integrity or triggering inflammatory responses and fibrosis.&lt;span&gt;&lt;sup&gt;7-9&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;In 2018, Reddy and colleagues&lt;span&gt;&lt;sup&gt;10&lt;/sup&gt;&lt;/span&gt; pioneered the application of PFA for the clinical management of paroxysmal AF Their groundbreaking work revealed that an average of 3.26 ablations was sufficient to achieve complete PVI with an operation duration of approximately 67 ± 10.5 min. The procedure was characterized by minimal chest and diaphragmatic sensations, yet remarkably, it resulted in no complications. Follow-up studies involving 81 patients undergoing mono-phase and bi-phase PFA demonstrated 100% acute isolation of pulmonary veins, with the procedure taking an average of 92.2 ± 27.4 min and the ablation itself 13.1 ± 7.6 min.&lt;span&gt;&lt;sup&gt;11&lt;/sup&gt;&lt;/span&gt; Given the pivotal role of pulmonary vein reconnection in ablation recurrence, the stability of PVI post-procedure emerges as crucial. Notably, advancements in PFA waveform technology have significantly increased PVI durability from 18% to a full 100% at the 3-month benchmark. Aside from a single incident of cardiac tamponade related to the operation, no severe complications were reported within the first 120 days post-ablation. At the one-year follow-up mark, the rate of sinus rhythm maintenance impressively stood at 87.4%. These findings collectively affirm the efficacy of PFA in achieving swift and durable PVI, primarily through selective myocardial tissue targeting, while maintaining a commendable safety profile.&lt;/p&gt;&lt;p&gt;Nevertheless, the inherent challenge of high recurrence rates i","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"287-291"},"PeriodicalIF":2.2,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12326","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A hypothesis: MiRNA-124 mediated regulation of sirtuin 1 and vitamin D receptor gene expression accelerates aging","authors":"Poulami Dhar,&nbsp;Shailaja Moodithaya,&nbsp;Prakash Patil,&nbsp;Kellarai Adithi","doi":"10.1002/agm2.12330","DOIUrl":"10.1002/agm2.12330","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Specific miRNAs are evident to be overexpressed with age, lifestyle, and environmental changes. Previous studies reported miR-124 overexpression in different scenarios in aged skin, age-related cognitive impairment, ischemic heart disease, muscle atrophy, and fractures. Thus miR-124 was considered to be a reliable miRNA target to establish a hypothesis on aging epigenome. Parallelly the hypothesis focuses on the expression of SIRT1 and VDR genes as a target for this specific miRNA expression as these genes were believed to be related to aging. This study aims to derive facts and evidence from past studies on aging. The objective was to establish a hypothetical linkage between miR-124 with age-related genes like SIRT1 and VDR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An in silico search was performed in the TargetScan and miRbase databases to analyze the aging-associated miRNAs and their gene targets, the Python seaborn library was used, and the results were represented in terms of a bar plot.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Based on an in silico analysis and studies available in the literature, we identified that miR-124-3p.1 and miR-124-3p.2 targets 3′ UTR of VDR and SIRT1 genes, and hence thereby indicates that the miR-124 can regulate the expression of these genes. Further, few in vitro research studies have observed that miR-124 overexpression leads to the downregulation of VDR and SIRT1 gene expression. These results indicate that the suppression of these target genes accelerates early aging and age-related disorders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Overall, this study hypothesizes that the overexpression of miR-124 diminishes the expression of VDR and SIRT1 genes, and thereby advances the process of aging, resulting in the development of age-associated complications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"320-327"},"PeriodicalIF":2.2,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12330","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141336458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guideline for the cognitive assessment and follow-up in the Guangdong-Hong Kong-Macao Greater Bay Area (2024 edition)","authors":"Jialing Peng,&nbsp;Yingreng Mai,&nbsp;Jun Liu","doi":"10.1002/agm2.12325","DOIUrl":"10.1002/agm2.12325","url":null,"abstract":"<p>This practice guideline focuses on the cognitive assessment for mild cognitive impairment in the Guangdong-Hong Kong-Macao Greater Bay Area. To achieve the standardization and normalization of its clinical practice and generate individualized intervention, the National Core Cognitive Center of the Second Affiliated Hospital of Guangzhou Medical University, the Cognitive Disorders Branch of Chinese Geriatic Society, the Dementia Group of Neurology Branch of Guangdong Medical Association and specialists from Hong Kong and Macao developed guidelines based on China's actual conditions and efficiency, economic cost and accuracy. The article addresses the significance, background, and the process of the assessment and follow-up to realize the promotion and dissemination of cognitive assessment.</p>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"258-268"},"PeriodicalIF":2.2,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12325","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141336801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical biomarker-based biological aging and risk of benign prostatic hyperplasia: A large prospective cohort study","authors":"Qiao Huang,&nbsp;Bing-Hui Li,&nbsp;Yong-Bo Wang,&nbsp;Hao Zi,&nbsp;Yuan-Yuan Zhang,&nbsp;Fei Li,&nbsp;Cheng Fang,&nbsp;Shi-Di Tang,&nbsp;Ying-Hui Jin,&nbsp;Jiao Huang,&nbsp;Xian-Tao Zeng","doi":"10.1002/agm2.12331","DOIUrl":"10.1002/agm2.12331","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Chronological age (CAge), biological age (BAge), and accelerated age (AAge) are all important for aging-related diseases. CAge is a known risk factor for benign prostatic hyperplasia (BPH); However, the evidence of association of BAge and AAge with BPH is limited. This study aimed to evaluate the association of CAge, Bage, and AAge with BPH in a large prospective cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>A total of 135,933 males without BPH at enrolment were extracted from the UK biobank. We calculated three BAge measures (Klemera–Doubal method, KDM; PhenoAge; homeostatic dysregulation, HD) based on 16 biomarkers. Additionally, we calculated KDM-BAge and PhenoAge-BAge measures based on the Levine method. The KDM-AAge and PhenoAge-AAge were assessed by the difference between CAge and BAge and were standardized (mean = 0 and standard deviation [SD] = 1). Cox proportional hazard models were applied to assess the associations of CAge, Bage, and AAge with incident BPH risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>During a median follow-up of 13.150 years, 11,811 (8.690%) incident BPH were identified. Advanced CAge and BAge measures were associated with an increased risk of BPH, showing threshold effects at a later age (all <i>P</i> for nonlinearity &lt;0.001). Nonlinear relationships between AAge measures and risk of BPH were also found for KDM-AAge (<i>P</i> = 0.041) and PhenoAge-AAge (<i>P</i> = 0.020). Compared to the balance comparison group (−1 SD &lt; AAge &lt; 1 SD), the accelerated aging group (AAge &gt; 2 SD) had a significantly elevated BPH risk with hazard ratio (HR) of 1.115 (95% CI, 1.000–1.223) for KDM-AAge and 1.180 (95% CI, 1.068–1.303) for PhenoAge-AAge, respectively. For PhenoAge-AAge, subgroup analysis of the accelerated aging group showed an increased HR of 1.904 (95% CI, 1.374–2.639) in males with CAge &lt;50 years and 1.233 (95% CI, 1.088–1.397) in those having testosterone levels &lt;12 nmol/L. Moreover, AAge-associated risk of BPH was independent of and additive to genetic risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Biological aging is an independent and modifiable risk factor for BPH. We suggest performing active health interventions to slow biological aging, which will help mitigate the progression of prostate aging and further reduce the burden of BPH.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"393-405"},"PeriodicalIF":2.2,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12331","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141339995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abuse and other factors related to depression in older Ecuadorian adults","authors":"Brenda Lorena Pillajo Sánchez,&nbsp;Marcos Serrano-Dueñas,&nbsp;Diego Alexander Mendoza Panta,&nbsp;Juana Albertina Moncayo Vásquez","doi":"10.1002/agm2.12338","DOIUrl":"10.1002/agm2.12338","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To identify abuse and other risk factors associated with depression in older Ecuadorian adults using data from the 2012 Ecuador's Survey of Health, Welfare, and Aging (SABE).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study analyzed data from the 2012 SABE survey, which included 5235 adults aged 60 and above. The study evaluated residence, education level, ethnic self-identification, self-perceived health and memory, loneliness, cognitive status, and abuse. Depression was assessed using the Yesavage Depression Scale, short version (YDS-SV). Categorical variables were analyzed with the Chi-square test, differences between groups were calculated with the Kruskal–Wallis test, and multiple linear regression analysis was performed. A <i>p</i>-value of ≤0.05 was considered statistically significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean age was 71.39 ± 8.59 years and 55.10% of the sample were women. Abuse was absent in 72.1% (3.773) of the population. The Chi-square test indicated significant associations between depression and poor self-reported health (<i>P</i> = 0.000) and indigenous ethnicity (<i>P</i> = 0.000). Multiple linear regression analysis revealed that age (<i>P</i> &lt; 0.001), abuse (<i>p</i> &lt; 0.001), cognitive status (<i>P</i> = 0.002), and living alone (<i>P</i> = 0.034) significantly contributed to mood as assessed by the YDS-SV. No statistically significant association was found for perceived health status or place of residence (urban or rural).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Risk factors associated with depression in older Ecuadorian adults include advanced age, living alone, cognitive decline, poor self-perception of health and cognition, and abuse.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"328-333"},"PeriodicalIF":2.2,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12338","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141341261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Craniectomy versus craniotomy: What can we do for acute subdural hematoma?","authors":"Shuo Zhang,&nbsp;Guoyi Gao,&nbsp;Weiming Liu","doi":"10.1002/agm2.12322","DOIUrl":"10.1002/agm2.12322","url":null,"abstract":"&lt;p&gt;Acute subdural hematoma (ASDH) is one of the common complications after traumatic brain injury (TBI) that warrants surgical evacuation. It often progresses rapidly and has a poor clinical prognosis, due to the mass effect caused by the hematoma and the invasion of the adjacent cerebral cortex and parenchyma. Although with the advancement of surgical techniques, the survival rate after ASDH increased from 59% in 1994–1998 to 73% in 2009–2013,&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; the surgical indications for hematoma evacuation and whether to perform decompression surgery are still controversial which depends on the patient's level of consciousness, pupil status, neuroimaging findings, and intracranial pressure.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; Hematoma evacuation is required in a quarter of patients to save lives.&lt;span&gt;&lt;sup&gt;3-5&lt;/sup&gt;&lt;/span&gt; At the same time, craniectomy was performed in another 25% of these patients to prevent postoperative brain edema or intraoperative brain tissue swelling, this proportion can be as high as nearly 50% in patients with severe traumatic brain injury in China.&lt;span&gt;&lt;sup&gt;6&lt;/sup&gt;&lt;/span&gt; In most cases, the primary motivation for emergency hematoma removal is to save lives or the noticeable space-occupying effect on computed tomography (CT) images,&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; however, if the intracranial pressure during emergency surgery allows, whether to remove the bone flap is an essential factor that probably affect the prognosis of patients.&lt;/p&gt;&lt;p&gt;Recently, in the New England Journal of Medicine, P. J. Hutchinson and colleagues address the comparison of surgical outcomes of craniotomy and decompressive craniectomy (RESCUE-ASDH trial),&lt;span&gt;&lt;sup&gt;7&lt;/sup&gt;&lt;/span&gt; it is an investigator-initiated, international, multicenter, pragmatic, randomized trial of patent with a bone flap greater than 11 cm in diameter who accepted the hematoma evacuation. Extended Glasgow Outcome Scale (GOSE) was used to evaluate patients’ outcomes after surgery 12 months later. The mortality and prognosis of the decompressive craniectomy and craniotomy groups were compared at 1, 6 months, and 1 year after operation, and there was no significance in disability and quality-of-life outcomes between two groups. However, the craniotomy group may have to face re-surgery due to difficult-to-control brain edema, while the decompressive craniectomy group may face more trauma-related complications.&lt;/p&gt;&lt;p&gt;The key conclusions of RESCUE-ASDH trial provide an essential reference for the decision-making of whether to remove the bone flap during the subdural hematoma surgery, that is, if no encephalocele occurs immediately during the operation, reduction of the skull with brain tissue no higher than the plane level of the skull does not increase the risk of poor prognosis. The conclusions are consistent with the recent findings of Thomas A. van Essen et al.,&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt; which pose a significant challenge to previous clinical practice.&lt;/p&gt;&lt;p&gt;Compared with intracranial","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 3","pages":"276-278"},"PeriodicalIF":2.2,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agm2.12322","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141343670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}