Precision Radiation Oncology最新文献

{"title":"Anlotinib helps alleviate radiation pneumonitis: A case report","authors":"Jiazhen Chen, Cunliang Wang, Xudong Hu","doi":"10.1002/pro6.1139","DOIUrl":"https://doi.org/10.1002/pro6.1139","url":null,"abstract":"Radiation pneumonitis is a serious side effect of thoracic radiotherapy with no established treatment currently. Anlotinib is a small‐molecule tyrosine kinase inhibitor (TKI) with anti‐angiogenic effects. The effect of TKIs in the treatment of radiation pneumonitis remains to be elucidated. We investigated whether anlotinib could alleviate radiation pneumonitis. We report a case of a patient with esophageal cancer who received anlotinib for radiation pneumonitis following radiotherapy. We also reviewed related studies to address this issue. The results in this patient suggest that anlotinib may be a valid treatment option for radiation pneumonitis.","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48272919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Status of radiotherapy staff during the coronavirus disease 2019 (COVID-19) epidemic in China.","authors":"Hui Wang,&nbsp;Lulu Chen,&nbsp;Zheming Liu,&nbsp;Ping Li,&nbsp;Tangpeng Xu,&nbsp;Zhenmin Fu,&nbsp;Qibin Song,&nbsp;Hongxue Wu,&nbsp;Xiangpan Li","doi":"10.1002/pro6.1134","DOIUrl":"https://doi.org/10.1002/pro6.1134","url":null,"abstract":"<p><strong>Objective: </strong>In December 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) broke out in Wuhan, China. The pandemic has posed a great challenge to radiation oncology departments, as interruptions in radiation therapy (RT) increase the risks of cancer recurrence or failure of the therapy as a whole. This study aimed to elucidate the impact of COVID-19 on radiation therapy staff in China.</p><p><strong>Methods: </strong>As many working staff at different radiation oncology departments in China as possible were retrospectively enrolled from 23 January to 9 March 2020. They were then invited to answer a questionnaire, for essential data collection, from which their basic information, anxiety level, and workload were analyzed.</p><p><strong>Results: </strong>Seven (0.39%) of the 1 755 radiation therapy staff who answered the questionnaire had contracted COVID-19, all of whom were from Wuhan. The factors influencing susceptibility were not sex (<i>P</i>  =  1.000), age (<i>P</i>  =  0.480), or comorbidities (<i>P</i>  =  0.600), but geographic location (<i>P</i> < 0.001) and whether the respondent worked in a designated COVID-19 hospital (<i>P</i>  =  0.003). In terms of protection procedures, four participants carried out basic, one second-level and two third-level protection procedures. The difference was not statistically significant (<i>P</i>  =  0.720). The infected respondents' anxiety level related to the outbreak (average score 6.57) was higher than that of their counterparts in Wuhan (5.18), as well as across the country (4.79), and 71.43% of those infected expressed the need for psychological interventions. During the epidemic, departments of 428 respondents (24.39%) shut down, while 76.71% of the respondents reported workload reduction.</p><p><strong>Conclusion: </strong>The factors related to COVID-19 infection were the geographic location and whether the respondent worked in a designated COVID-19 hospital. The infected respondents experienced greater psychological pressure than their uninfected counterparts and, therefore, required more psychological interventions.</p>","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5d/17/PRO6-5-222.PMC8661947.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39839529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is gamma knife radiosurgery for skull base meningiomas with carotid artery encasement supported by efficacy and safety outcomes?","authors":"F. Ampil, A. Sin, Donald R. Smith","doi":"10.1002/pro6.1132","DOIUrl":"https://doi.org/10.1002/pro6.1132","url":null,"abstract":"Clinical outcomes were reviewed in 30 patients treated by gamma knife radiosurgery for skull base meningiomas with carotid artery encasement (SKBM‐CAE). The overall clinical improvement rate after treatment was 46%. At a median imaging follow‐up of 49 months, tumor volumes were unchanged, were larger, and were smaller or had resolved in 70%, 23%, and 7% of cases, respectively. The crude survival rate at 10 years was 20% and the complication (new cranial nerve deficit not accompanied by imaging‐shown tumor growth) rate was 10%. SKBM‐CAE is amenable to being effectively and safely controlled with the application of gamma knife radiosurgery.","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43372487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of refractory mycetoma by radiotherapy: a case study and review","authors":"Anil Gupta, D. Sharma, Somesh Gupta, Seema Sharma, T. Dev, Suvesh Singh, R. Mücke, O. Micke","doi":"10.1002/pro6.1125","DOIUrl":"https://doi.org/10.1002/pro6.1125","url":null,"abstract":"Mycetoma is a localized chronic subcutaneous infection caused by fungi. It is clinically characterized by a triad of tumefaction, sinuses, and discharge containing typical grains. Eumycetoma, a subtype, is characterized by a low cure rate. Long‐term medication and surgical excision are required to treat the infection. Radiotherapy, a less used modality of treatment, may provide a good salvage option for refractory eumycetoma. Herein, we present a case and a review of the literature of refractory eumycetoma of the foot where radiotherapy was used as a salvage treatment. In the present case, a dose of 17.5 Gy in five fractions was delivered, and the response was assessed as per the Response Evaluation Criteria in Solid Tumors 1.1, discharging grains status, and Dermatology Life Quality Index. The literature on the use of radiotherapy for mycetoma was found to be scanty. In the present case with radiotherapy, there was a partial radiological response, resolution of discharging grains, and improvement in the Dermatology Life Quality Index score. However, the benefit was short‐lived, but re‐irradiation and low‐dose radiotherapy resulted in sustained benefits until 15 months of follow up. The antiproliferative and anti‐inflammatory actions of radiotherapy can be exploited in the treatment of rare, medically difficult to treat mycetoma. This case report may serve as a basis for further evaluation.","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44945738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dosimetric validation of two different radiobiological models for parotid gland functionality of tongue cancer","authors":"S. Pramanik, S. Bera, Sanjoy Roy, A. Ray, S. Sarkar, D. Majumder","doi":"10.1002/pro6.1130","DOIUrl":"https://doi.org/10.1002/pro6.1130","url":null,"abstract":"The aim of this study was to investigate the normal tissue complication probability (NTCP) for parotid gland of ca tongue patients from two different radiobiological models and to establish a dosimetric validity.","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49442457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for radiotherapy of nasopharyngeal carcinoma","authors":"Rensheng Wang, Min Kang","doi":"10.1002/pro6.1123","DOIUrl":"https://doi.org/10.1002/pro6.1123","url":null,"abstract":"With the extensive application of intensity‐modulated conformal radiotherapy and the deepening of the concept of comprehensive treatment, the therapeutic effect of nasopharyngeal carcinoma and the quality of life of patients have been significantly improved. However, guidelines for radiotherapy of nasopharyngeal carcinoma in China are in short supply. Dozens of experts from the Radiation Oncology Physicians Branch of the Chinese Medical Doctor Association and the Radiation Oncology Branch of the Chinese Medical Association have developed the publication Guidelines for radiotherapy of nasopharyngeal carcinoma in China after discussion. The guidelines include the epidemiology, diagnosis, clinical stage, treatment principle, and treatment of complications of radiotherapy of nasopharyngeal carcinoma. Importantly, the procedure of radiotherapy for nasopharyngeal carcinoma has been developed, which covers the imaging of nasopharyngeal carcinoma, radiotherapy localization, target area delineation, dose limitation, and plan evaluation. The guidelines will help to realize the homogenization of the diagnosis and treatment of nasopharyngeal carcinoma among radiotherapeutic medical staff in different levels of hospitals in China, thereby improving the overall level of diagnosis and treatment of nasopharyngeal carcinoma in China.","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48994167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple severe late adverse effects after definitive chemoradiation for locally advanced cervical cancer","authors":"C. Danko, L. Hong, J. Slater","doi":"10.1002/pro6.1126","DOIUrl":"https://doi.org/10.1002/pro6.1126","url":null,"abstract":"Concurrent chemoradiation is the standard of care for locally advanced cervical cancer and is commonly associated with mild to moderate toxicities. Severe late complications in multiple organ systems in patients without known patient‐ or treatment‐related risk factors are rare. A 42‐year‐old woman was treated with definitive chemoradiotherapy with external beam radiotherapy and brachytherapy. She had complete resolution of the disease, with no evidence of recurrence. However, she experienced late morbidity in multiple organ systems due to treatment, likely indicating an increased sensitivity to radiation. This case highlights the need for improvements in the identification of such patients.","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/pro6.1126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49106793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediastinal and neck follicular dendritic cell sarcoma treated with definitive radiation therapy using the volumetric modulated arc therapy technique: a case report","authors":"Adnan Calcuttawala, Nilesh Deshmane, Jaydeep N Pol, Sharad Desai","doi":"10.1002/pro6.1124","DOIUrl":"https://doi.org/10.1002/pro6.1124","url":null,"abstract":"Follicular dendritic cell sarcoma (FDCS) is a rare malignancy that affects the nodal and extranodal tissues. The mediastinum is a rare site for this tumor, with few published reports and series. Although surgery is the mainstay of treatment for this disease entity, in this report we present a case of mediastinal FDCS treated with definitive radiation therapy (RT) with a near‐total radiological response. A 28‐year‐old woman presented with chest tightness and neck swelling. Radiological findings were suggestive of a conglomerated nodal mass involving the mediastinum and extending superiorly into the anterior neck. Biopsy results led to a diagnosis of FDCS. The tumor was deemed unresectable, and definitive RT was planned as the treatment. The patient was treated with volumetric modulated arc therapy to a total dose of 54 Gy in 30 fractions over 6 weeks. Her symptoms had completely resolved at the first follow‐up visit, 3 months after RT completion, with a near‐total radiological response on a contrast‐enhanced computed tomography scan. Although surgery is the standard of care in FDCS, based on the favorable response of FDCS to RT, as in this case, the role of definitive RT needs to be studied in more patients to determine its efficacy in long‐term tumor control as an alternative to surgery.","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/pro6.1124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41827852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consideration of the target area of radiotherapy for lung cancer with 4DPET","authors":"Zhang Yanlan, L. Xianfeng, Huang Lingjun","doi":"10.1002/pro6.1131","DOIUrl":"https://doi.org/10.1002/pro6.1131","url":null,"abstract":"Through the study of 4‐dimensional (4D) positron emission tomography (PET)/computed tomography (CT) for lung tumor, the delineation of the lung tumor target area was analyzed, the accurate target area was received, and the radiation dose of normal tissue was compared .","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41552845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for radiotherapy of prostate cancer (2020 edition)","authors":"Gaofeng Li, Yexiong Li, Junjie Wang, Xian-shu Gao, Q. Zhong, Liru He, Chunmei Li, Ming Liu, Yueping Liu, M. Ma, Hao Wang, Xuan Wang, Hui Zhu","doi":"10.1002/pro6.1129","DOIUrl":"https://doi.org/10.1002/pro6.1129","url":null,"abstract":"In recent years, the incidence of prostate cancer in China has shown a trend of continuous growth. Prostate cancer has become a urinary malignant tumor that seriously affects the health of men in China. Radical surgery and precision radiotherapy are the main methods of radical treatment for prostate cancer. Standardized diagnosis and treatment via a multidisciplinary team should be the standard practice to improve cure rate. Rapid development in imaging, pathology and molecular gene diagnosis has significantly changed the management of prostate cancer. In radiation oncology, image‐guided intensity modulated radiotherapy has been widely adopted in the treatment of prostate cancer. The comprehensive approach centered with radiotherapy has achieved excellent curative effect while continuously reducing treatment‐related side effects.","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48971492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}