Chemosphere最新文献

{"title":"Unexpected nanoscale CeO2 structural transformations induced by ecologically relevant phosphate species","authors":"Tatiana V. Plakhova ,&nbsp;Maria A. Vyshegorodtseva ,&nbsp;Irina F. Seregina ,&nbsp;Roman D. Svetogorov ,&nbsp;Alexander L. Trigub ,&nbsp;Daniil A. Kozlov ,&nbsp;Alexander V. Egorov ,&nbsp;Maria D. Shaulskaya ,&nbsp;Dmitry M. Tsymbarenko ,&nbsp;Anna Yu. Romanchuk ,&nbsp;Vladimir K. Ivanov ,&nbsp;Stepan N. Kalmykov","doi":"10.1016/j.chemosphere.2024.143664","DOIUrl":"10.1016/j.chemosphere.2024.143664","url":null,"abstract":"<div><div>In the present study, the dissolution and microstructural transformation of CeO₂ nanoparticles (NPs) in a phosphate-containing milieu were investigated. The dissolution behaviour of 2 nm and 5 nm CeO₂ NPs in phosphate buffer solutions was found to differ markedly from that observed in 0.01 M NaClO₄. Through synchrotron X-ray diffraction analysis and X-ray absorption spectroscopy, the interaction between CeO₂ NPs and phosphate species was examined, revealing the transformation of the oxide into sodium-cerium double phosphate, with cerium predominantly existing in the Ce(IV) state. According to scanning and transmission electron microscopy observations, thus formed Na-Ce(IV) phosphate consists of spindle-like aggregates of nanocrystalline rods, presumably formed during phosphate anions sorption on the initial CeO₂ surface. Pair distribution function analysis revealed that Na-Ce(IV) phosphate has a three-dimensional framework crystal structure, similar to NaTh₂(PO₄)₃, as reported earlier, with large channels along the c-axis containing disordered sodium atoms. This study represents the first detailed analysis of phosphate-induced speciation and microstructural transformation of CeO₂ NPs, resulting in the formation of Ce(IV) phosphate. Similar processes may occur in natural ecosystems upon the introduction of CeO₂ NPs.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"368 ","pages":"Article 143664"},"PeriodicalIF":8.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms underlying mitochondrial dysfunction and intestinal damage induced by ingestion of microplastics in Leuciscus waleckii: The role of the NF-κB/Nrf2 signaling pathway","authors":"Si Ying Liu ,&nbsp;Deng Lai Li ,&nbsp;Rui Zhu ,&nbsp;Si Tong Meng ,&nbsp;Yin Tao Wang ,&nbsp;Liang Li ,&nbsp;Zhi Yong Yang ,&nbsp;Li Fang Wu","doi":"10.1016/j.chemosphere.2024.143676","DOIUrl":"10.1016/j.chemosphere.2024.143676","url":null,"abstract":"<div><div>This study investigates the impact of polystyrene microplastics (PS-MPs) on the growth, immunity, oxidative stress, mitochondrial function, and intestinal health of <em>Leuciscus waleckii</em> (3.00 ± 0.02 g) juveniles over 8 weeks. Our findings indicate that exposure to PS-MPs negatively affected the growth of <em>Leuciscus waleckii</em>, resulting in digestive disturbances. Furthermore, PS-MPs triggered immune dysfunction and oxidative stress through the activation of the NF-κB pathway and suppression of the Nrf2 signaling cascade. PS-MPs damaged intestinal tissue and compromised the intestinal barrier. Additionally, mitochondrial homeostasis was disrupted, activating endogenous mitochondrial apoptotic pathways, ultimately leading to cell apoptosis. High-throughput 16S rRNA sequencing disclosed that PS-MPs provoked shifts in the intestinal microbiota. Mantel analysis indicates significant correlations between growth parameters and the activities of enzymes related to antioxidant defense, immunity, apoptosis, and mitochondria, as well as with the gut microbiota. In summary, our study reveals that PS-MPs induce intestinal inflammation and oxidative stress in <em>Leuciscus waleckii</em> by activating the NF-κB pathway and the intrinsic mitochondrial apoptotic pathway while repressing the Nrf2 signaling, ultimately leading to cellular apoptosis, mitochondrial dysfunction, intestinal microbiota imbalance, and growth inhibition.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"367 ","pages":"Article 143676"},"PeriodicalIF":8.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive multi-tiered approach to assessing weather penalties on O3 levels and exceedance days in Seoul using generalized additive models (2001–2019)","authors":"Min Young Shin ,&nbsp;Hyung Joo Lee","doi":"10.1016/j.chemosphere.2024.143687","DOIUrl":"10.1016/j.chemosphere.2024.143687","url":null,"abstract":"<div><div>Over the past two decades, ambient O₃ air pollution in Seoul, the capital city of South Korea, has increased. As a secondary air pollutant, O₃ is affected not only by precursor gas emissions but also by meteorological conditions. This study examined the influence of weather changes in Seoul for 2001–2019 on the long-term daily maximum 8-h O₃ concentration (MDA8 O₃) trends measured at 25 monitoring sites. As the relationship between O₃ and meteorological variables may not be linear, we used a generalized additive model framework to estimate O₃ trends, incorporating quantile and logistic regressions for continuous O₃ data and O₃ exceedance days (&gt;60 ppb), respectively. Over the 19-year period, the O₃ concentrations in Seoul increased by 14.7 (SD = 3.2) and 13.1 (SD = 3.1) ppb before and after adjusting for local meteorology, respectively, resulting in an average weather penalty of 1.55 ppb. Seasonal variations in the penalty were substantial, showing a greater penalty (4.5 ppb) during the warm season (May–October) than during the cold season (November–April). Furthermore, the increase in O₃ concentration was more pronounced on days with comparatively high O₃ levels. During the warm season, the weather penalties on O₃ trends reached 3.7–4.0 ppb on high-O₃ days (75^th, 95^th, and 99^th percentiles). From 2001 to 2019, the O₃ exceedance days started 2.66 days earlier and ended 2.30 days later per year, extending the peak-O₃ season by approximately 89 days in total. Weather changes accelerated the upward trend in the odds ratio of O₃ exceedance days by 3.8 years. Our findings indicate that O₃ exceedance days can occur in nearly all months owing to weather changes. The significant weather penalties on O₃ concentrations and exceedance days emphasize the need for a comprehensive O₃ air pollution mitigation strategy, considering non-emission factors that are increasingly being recognized in the context of climate change.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"368 ","pages":"Article 143687"},"PeriodicalIF":8.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards harmonization of metal(loid)s determination in conventional and compostable plastics: Comparison of acid digestion protocols in LDPE and PBAT/TPS blends","authors":"Stefano Carnati ,&nbsp;Andrea Pozzi ,&nbsp;Davide Spanu ,&nbsp;Roberta Bettinetti ,&nbsp;Luca Nizzetto ,&nbsp;Gabriela Kalčíková ,&nbsp;Ludovica Botta ,&nbsp;Gilberto Binda","doi":"10.1016/j.chemosphere.2024.143581","DOIUrl":"10.1016/j.chemosphere.2024.143581","url":null,"abstract":"<div><div>The determination of metal-containing additives in plastic materials via acid digestion protocols has attracted growing interest to address potential environmental implications. However, the lack of protocol harmonization hinders data comparability within the literature. Here, six acid digestion protocols were employed to determine the metal(loid) content in plastics: these included three different acid mixtures (HNO₃ combined with H₂SO₄, HCl or H₂O₂) for microwave-assisted digestion, with or without an additional room-temperature digestion step with H₂O₂.</div><div>Each protocol was first validated for seven metal(loid)s (As, Cd, Cr, Pb, Sb, Sn and Zn) using a low-density polyethylene (LDPE) certified reference material (ERM®-EC681m). Then, validated protocols were applied on end-use materials, including conventional (i.e., LDPE) and compostable (i.e., PBAT/TPS) plastics.</div><div>The combination of H₂SO₄ and HNO₃ with a further digestion step with H₂O₂ was the most suitable protocol: it successfully passed validation thresholds for all metal(loid)s (recoveries in the range 98.6–101.0 %) and yielded the highest concentrations in end-use materials. All other protocols resulted in a less efficient digestion of the sample matrix, leading to lower recoveries and the formation of solid residues. Notably, end-use plastics showed a great variability in metal(loid) concentrations, likely due to their additive-rich composition, in contrast to the minimal content of acid-soluble additives of the reference material.</div><div>This study represents an initial step towards the harmonization of acid digestion protocols and highlights new challenges in accurately analyzing end-use plastic materials, due to their complex additive composition.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"367 ","pages":"Article 143581"},"PeriodicalIF":8.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142483119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A convenient reduction method for the detection of low concentration free available chlorine——utilizing sodium sulfite as a quencher","authors":"Meiyao Han ,&nbsp;Shiyue Huang ,&nbsp;Xiaoxiao Zhang ,&nbsp;Ke Zhang","doi":"10.1016/j.chemosphere.2024.143631","DOIUrl":"10.1016/j.chemosphere.2024.143631","url":null,"abstract":"<div><div>Chlorine, serving as the mainstream disinfectant, can react with dissolved organic matter (DOM) to form undeserved disinfection by-products (DBPs). Free available chlorine (FAC) concentration is crucial to ensure effective disinfection while minimizing the formation of toxic DBPs. In this study, we propose a convenient method using sodium sulfite (Na₂SO₃) to reduce oxidized chlorine in FAC. The molar concentration of reduced chloride ion (Cl⁻) was quantified directly by ion chromatography to reflect FAC concentration. Compared with common FAC detection techniques including DPD colorimetry, iodometry, and UV methods, this novel reduction method exhibits a lower detection limit and is more resistant to interference. Common water matrices, such as DOM and anions did not affect the method accuracy (&lt; 3.6%). Furthermore, carbonaceous DBPs (C-DBPs) like regulated trihalomethanes and halogenacetic acids, unregulated aromatic chlorophenols, did not interfere with the determination of FAC by using this reduction method. This lack of interference can be attributed to the low redox potential of Na₂SO₃, which does not readily react with these C-DBPs. However, nitrogenated DBPs (N-DBPs) like dichloroacetonitrile displayed slight interference (the effect of common dichloroacetonitrile concentration in water on FAC was less than 0.0007 μM). This suggests that this method is well-suited for determining FAC in chlorination processes where the C-DBPs predominated. Overall, the reduction method enables precise determination of FAC and proves valuable in assessing residual chlorine levels in both laboratory and real disinfected water samples dominated by C-DBPs.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"367 ","pages":"Article 143631"},"PeriodicalIF":8.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parabens, triclosan, and triclocarban in aquatic products from Shenzhen, China and the relative health risk","authors":"Qinru Xiao ,&nbsp;Xiaoqiong Xu ,&nbsp;Leyi Chen ,&nbsp;Bingyi Fu ,&nbsp;Jiajun Cao ,&nbsp;Jiayi Liu ,&nbsp;Han Zhang ,&nbsp;Shaoyou Lu","doi":"10.1016/j.chemosphere.2024.143652","DOIUrl":"10.1016/j.chemosphere.2024.143652","url":null,"abstract":"<div><div>The consumption of contaminated aquatic products may expose humans to residues of parabens, triclosan (TCS), and triclocarban (TCC). Despite its significance, empirical research on this issue remains limited. In this study, we employed high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to analyze extracts from 245 aquatic product samples collected randomly from local markets in Shenzhen, Guangdong Province. Our analysis detected at least one of the five parabens—methyl 4-hydroxybenzoate (MeP), ethyl 4-hydroxybenzoate (EtP), propyl 4-hydroxybenzoate (PrP), butyl 4-hydroxybenzoate (BuP), and benzyl 4-hydroxybenzoate (BeP)—in 88 samples (35.9%). TCS and TCC were found in 50.6% and 51.4% of the samples, respectively, with MeP being the most frequently detected paraben. Significant negative correlations were observed between TCS and MeP (<em>r</em> = −0.129, <em>p</em> &lt; 0.05) and between TCC and MeP (<em>r</em> = −0.176, <em>p</em> &lt; 0.05), indicating potential different sources for these contaminants. Residue levels varied among different types of aquatic products, with TCS and TCC concentrations being higher in fish compared to crustaceans and bivalves. The health risk associated with consuming these contaminants was found to be minimal for both males and females. This study provides valuable insights into the dietary risks associated with exposure to parabens, TCS, and TCC.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"367 ","pages":"Article 143652"},"PeriodicalIF":8.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the impact of residual low chlorine concentration on phytoplankton communities by flow cytometry","authors":"Marta Vannoni ,&nbsp;Alastair Grant ,&nbsp;Dave Sheahan ,&nbsp;Véronique Créach","doi":"10.1016/j.chemosphere.2024.143634","DOIUrl":"10.1016/j.chemosphere.2024.143634","url":null,"abstract":"<div><div>Chlorination is widely used to prevent biological fouling in power station cooling water systems. It may impact non-target organisms both within the cooling system and after discharge (primary and secondary entrainment). However, there is a lack of data on the impacts of the low chlorine concentrations that occur in the discharged plume on marine phytoplankton community structure and function.</div><div>We examine the impacts on natural phytoplankton communities of single and multiple exposures to chlorination at concentrations between 0.02 and 0.1 mg/L total residual oxidants (TRO). Low-level chlorination causes limited changes in diversity and has no impact on total biomass. However, changes in size structure and functional diversity quantified using flow cytometry do show a reduction in smaller cells, particularly eukaryote picophytoplankton.</div><div>These impacts are not detectable using chlorophyll <em>a</em> concentration alone, so flow cytometry provides important additional information over more standard ecotoxicological methods.</div><div>The effects are likely to be localised in the vicinity of the discharges (mixing zone) where the environmental quality standard (EQS) of 10 μg/L for chlorine is exceeded, but impacts on coastal food webs and biogeochemical cycles should be further evaluated.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"367 ","pages":"Article 143634"},"PeriodicalIF":8.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New insights into the improved contaminants removal in SBR by intermittently weak ultrasound","authors":"Jingshen Zhang ,&nbsp;Jinlin Wang ,&nbsp;Guirong Li ,&nbsp;Shengyong Jia ,&nbsp;Hongjun Han ,&nbsp;Fengchang Wu ,&nbsp;Yuanhu Pei","doi":"10.1016/j.chemosphere.2024.143674","DOIUrl":"10.1016/j.chemosphere.2024.143674","url":null,"abstract":"<div><div>The combination of intermittently weak ultrasound and sequencing batch reactor was thoroughly investigated to elucidate the relationship between enhanced contaminants removal and activated sludge characteristics, microbial composition, and regulation of differentially expressed genes (DEGs). At 12 °C, irradiation with an ultrasound intensity of 9.68 W/L, an irradiation time of 10 min, and an interval time of 24 h led to significant increases in COD, NH₄⁺−N, and TP removals with the rates of 93.10 ± 1.51%, 95.75 ± 0.76%, and 92.52 ± 0.95%, respectively. The intermittently weak ultrasound enhanced contaminants removal was primarily attributed to the stimulated microbial metabolism, in which the mechanical oscillation rather than free radical oxidation facilitated the loosening of activated sludge flocs and promoted microorganism proliferation. Elevating the ultrasound intensity or irradiation time could weaken the effect of enhancing ammonia−oxidizing bacteria activity and suppressing nitrite−oxidizing bacteria activity. The results revealed that intermittently weak ultrasound primarily affected the extracellular polymeric substances (EPS), with protein nitrogen playing a more significant role than polysaccharide within EPS against ultrasound−induced stress. Furthermore, ultrasound irradiation elevated the energy barrier in total−binding EPS interaction energy curves, thereby inhibiting activated sludge aggregation. Over prolonged operation, the relative abundance of the prevalent denitrifying genus <em>Thauera</em> increased by 90.3%, whereas that of the fully aerobic denitrifier and nitrite producer <em>Dokdonella</em> increased by 68.7%. The intermittently weak ultrasound induced enhancement of microbial metabolism−related DEGs pathways, which served as the main contributor to the improved contaminants removal. These findings provide novel insights into the mechanisms by which intermittently weak ultrasound enhances the effectiveness of biological wastewater treatment.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"367 ","pages":"Article 143674"},"PeriodicalIF":8.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of polylactic acid microplastics during anaerobic co-digestion of cow manure and Chinese cabbage waste enhanced by nanobubble","authors":"Peilin Guo,&nbsp;Tianfeng Wang,&nbsp;Jie Wang,&nbsp;Jiazi Niu,&nbsp;Cheng Peng,&nbsp;Jiabei Shan,&nbsp;Yu Zhang,&nbsp;Haizhou Huang,&nbsp;Jixiang Chen","doi":"10.1016/j.chemosphere.2024.143639","DOIUrl":"10.1016/j.chemosphere.2024.143639","url":null,"abstract":"<div><div>With the increasing use of plastic products globally, environmental pollution by plastic waste is becoming increasingly problematic. This study investigated the impacts of two types of polylactic acid microplastics, clear microplastics and aluminised film microplastics, on methane yield, microbial community, and volatile fatty acid accumulation during anaerobic co-digestion of cow manure and Chinese cabbage waste under different temperature conditions. The influence of the addition of air nanobubbles on microplastic degradation in the anaerobic digestion system we also examined. The results revealed that under thermophilic conditions, clear and aluminised film microplastics increased the methane yield, with the latter resulting in greater improvement. Conversely, under mesophilic conditions, the presence of microplastics reduced the methane yield, but the addition of air-nanobubble partially mitigated this effect. Microplastics also affected the microbial community, with specific species showing correlations with methane yield. <em>Methanothermobacter</em>, which is linked to lactic acid conversion, was positively correlated with methane yield, whereas <em>Methanomassiliicoccus</em> levels increased in the presence of microplastics, particularly in the inhibited state of the digester. These results suggest that, under thermophilic conditions, microplastics may increase the cumulative methane yield by facilitating the degradation of lactic acid monomers. Furthermore, the aluminised film on microplastics could serve as an electrically conductive material during anaerobic digestion, potentially increasing the methane yield.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"367 ","pages":"Article 143639"},"PeriodicalIF":8.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic potential & molecular mechanism of skin sensitization of cinnamaldehyde under environmental UVB exposure","authors":"Sunil Kumar Patel ,&nbsp;Apeksha Vikram ,&nbsp;Diksha Pathania ,&nbsp;Rashi Chugh ,&nbsp;Prakriti Gaur ,&nbsp;Gaurav Prajapati ,&nbsp;Sumana Y. Kotian ,&nbsp;G.N.V. Satyanarayana ,&nbsp;Akhilesh Kumar Yadav ,&nbsp;Atul Kumar Upadhyay ,&nbsp;Ratan Singh Ray ,&nbsp;Ashish Dwivedi","doi":"10.1016/j.chemosphere.2024.143508","DOIUrl":"10.1016/j.chemosphere.2024.143508","url":null,"abstract":"<div><div>Fragrance, a key ingredient in cosmetics, often triggers skin allergy causes rashes, itching, dryness, and cracked or scaly skin. Cinnamaldehyde (CA), derived from the bark of the cinnamon tree, used as a fragrance and is a moderate skin sensitizer. CA exhibits strong UVB absorption, its allergic potential and the molecular mechanisms underlying skin sensitization under UVB exposure remain largely unexplored. To investigate the allergic potential and molecular mechanisms of CA-induced skin sensitization under ambient UVB radiation, we employed various alternative <em>in-silico</em>, <em>in-chemico</em> and <em>in-vitro</em> tools. CA under ambient UVB isomerizes from <em>trans to cis</em> CA after 1hr of exposure. Furthermore, DPRA assay and docking with simulation studies demonstrated the enhanced allergic potential of <em>cis</em>-CA. Additionally, our study evaluated intracellular ROS levels and the expression of Nrf2, Catalase, and MMP-2, and 9 in KeratinoSens cells, showing significant upregulation under UVB exposure in the presence of CA. Moreover, our findings indicate that CA activates THP-1 cells co-stimulatory surface marker (CD86) via the activation of intracellular ROS, phagocytosis, and genes of the TLR4 pathway. These insights into the mechanisms uncovered by our study are crucial for managing triggers of allergic skin diseases caused by fragrance use and concurrent exposure to environmental UVB/sunlight.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"368 ","pages":"Article 143508"},"PeriodicalIF":8.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}