Proceedings of the 7th World Congress on Recent Advances in Nanotechnology最新文献

{"title":"Functionalizing Gold Nanostars with Ninhydrin as Vehicle Molecule for Biomedical Applications","authors":"Swati Mishra","doi":"10.11159/nddte22.130","DOIUrl":"https://doi.org/10.11159/nddte22.130","url":null,"abstract":"In recent years, there has been an explosion in Gold NanoParticle (GNP) research, with a rapid increase in publications in diverse fields, including imaging, bioengineering, and molecular biology. GNPs exhibit unique physicochemical properties, including surface plasmon resonance (SPR) and bind amine and thiol groups, allowing surface modification and use in biomedical applications. Nanoparticle functionalization is the subject of intense research, with rapid progress being made towards developing biocompatible, multi-functional particles. In the present study, the photochemical method has been done to functionalize various-shaped GNPs like nanostars by the molecules like ninhydrin. Ninhydrin is bactericidal, virucidal, fungicidal, antigen-antibody reactive, and used in fingerprint technology in forensics. The GNPs functionalized with ninhydrin efficiently will bind to the amino acids on the target protein, which is of eminent importance during the pandemic, especially where long-term treatments of COVID-19 bring many side effects of the drugs. The photochemical method is adopted as it provides low thermal load, selective reactivity, selective activation, and controlled radiation in time, space, and energy. © 2022, Avestia Publishing. All rights reserved.","PeriodicalId":276715,"journal":{"name":"Proceedings of the 7th World Congress on Recent Advances in Nanotechnology","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124450210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Raman Spectroscopy for the Characterization of Multifunctional Nanoliposomes for Alzheimer's disease and Glioblastoma","authors":"Valentina Mangolini, S. Picciolini, Francesca Rodà, A. Gualerzi, F. Re, A. Antoniou, Sabrina Giofrè, Marzia Bedon","doi":"10.11159/nddte22.145","DOIUrl":"https://doi.org/10.11159/nddte22.145","url":null,"abstract":"In recent years, the ongoing growing and ageing world population has led to an increased incidence of neurological disorders. Despite efforts in researching innovative therapies against various brain diseases, the main problem that still exists today is the delivery of drugs to the brain. The blood brain barrier (BBB) has unique anatomical features that mirror its protective role in maintaining the microenvironment within the brain. Thanks to its special anatomical structure, the BBB regulates the exchange of substances between blood and the cerebral parenchyma. This is very important to protect the central nervous system (CNS), but on the other hand it prevents the passage of pharmacological substances that are useful for the treatment of brain disorders. [1] Among disorders, Alzheimer's disease is most form of dementia in the elderly population, while Glioblastoma","PeriodicalId":276715,"journal":{"name":"Proceedings of the 7th World Congress on Recent Advances in Nanotechnology","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116575000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solid Lipid Nanoparticles for Ocular Delivery of Posaconazole: Design, Optimization and Evaluation\u0000Assay","authors":"Ali Asram Sağıroğlu","doi":"10.11159/nddte22.116","DOIUrl":"https://doi.org/10.11159/nddte22.116","url":null,"abstract":"Extended Abstract Ocular drug delivery continues challenging due to the unique anatomic and physiological properties of the eye. Although the drugs are easily applied topically to the eye, different barriers such as the cornea, conjunctiva, blood-aqueous barrier, and blood-retinal barrier limit the reaching of the drugs to the target area [1]. In addition, due to some effective mechanisms such as blinking, tear turnover and drainage, the duration of the applied formulation in the eye area is very limited. For these reasons, drugs administered by the ocular route cannot reach the target area at the desired concentration and cannot remain in the ocular area for a sufficient period of time [2]. Conventional dosage forms cannot indicate enough efficacy since they are quickly removed from the eye surface by eyelid movements and tears [3]. Therefore, it is significant to design a suitable ocular drug delivery system to increase the bioavailability of drugs. To overcome the problem of bioavailability in ocular drug delivery, it was planned to prepare solid lipid nanoparticles (SLN) systems that are using for their penetration enhancer effect in different barriers of the eye SLN are nanometer-sized particles prepared with solid lipids at room and body temperature and stabilized with emulsifiers. The use of SLN in ocular drug delivery has been increasing in recent years thanks to its advantages such as not showing toxicity problems, having high penetration ability in different barriers of the eye, increasing the ocular bioavailability and being suitable for large-scale production In addition, SLN enables autoclave sterilization,","PeriodicalId":276715,"journal":{"name":"Proceedings of the 7th World Congress on Recent Advances in Nanotechnology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123313431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heteroatom-Doped Carbon Quantum Dots as Electrocatalysts for the Oxygen Reduction Reaction","authors":"P. Knauth, M. D. Vona","doi":"10.11159/icnnfc22.002","DOIUrl":"https://doi.org/10.11159/icnnfc22.002","url":null,"abstract":"The oxygen reduction reaction (ORR) is one of the most fascinating electrochemical reactions, especially for applications in alkaline fuel cells and metal-air batteries. Over the last few years, research steadily shifted towards anion exchange membrane fuel cells (AEMFC) that can perform without noble metal catalysts at the cathode with the perspective of a significant reduction of cost and use of strategic rare metals. The 4-electron ORR can be written in alkaline conditions: (1) In this work, we investigate metal-free catalysts based on heteroatom-doped carbon quantum dots (CQD) synthesized by a hydrothermal method from inexpensive and non-toxic precursors [1] and including anion-exchange ionomers. Ionomers contribute to lower aggregation of CQD and increase the catalytic activity by fast transport of OH - ions. We have examined the catalytic behavior of CQD for the ORR in alkaline conditions with various methods of electrode preparation, such as drop-casting and electrospinning","PeriodicalId":276715,"journal":{"name":"Proceedings of the 7th World Congress on Recent Advances in Nanotechnology","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127213987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aggregation-Induced Changes in Optical Characteristics of CdSe/ZnS Quantum Dots","authors":"T. Oskolkova, E. Kolesova, A. Orlova","doi":"10.11159/icnnfc22.157","DOIUrl":"https://doi.org/10.11159/icnnfc22.157","url":null,"abstract":"Extended Abstract Over the past decades, semiconductor quantum dots (QDs) along with their remarkable size-dependent optical and electrochemical properties have attracted considerable research interest. Modern studies have opened up the possibility of employing these nanomaterials in the variety of applications, ranging from bioimaging and fluorescent labeling [1] to new-generation solar cell and display fabrication [2]. The widespread usage of QDs has led to a necessity of understanding the factors that affect optical properties of these nanostructures. For instance, QDs, as well as colloidal nanoparticles of other types, tend to aggregate upon environmental changes [3–5]. The decrease in interdot distance initiated by the aggregation process promotes efficient QDs interactions and gives rise to the Förster resonance energy transfer (FRET) between proximal dots within the aggregate [6]. The FRET process is considered to be the reason of rapid changes in optical characteristics of aggregated QDs. The present study is focused on the effect of aggregation on optical properties of colloidal core-shell CdSe/ZnS QDs. The aggregates were formed by adding methanol to the QDs solution in chloroform. To monitor the process of aggregation, hydrodynamic diameters of particles were evaluated by Dynamic Light Scattering (DLS) technique. DLS measurements showed good agreement with the data obtained from scanning electron microscopy. Optical characterization of QDs was provided by photoluminescence (PL) and UV-VIS spectroscopy. The QD aggregation was accompanied by an 80% decrease in PL intensity and a red shift of the spectral peak by 10 nm, while the PL quantum yield reduced from 10% to 2%. As for the absorption spectra, QDs in both monodispersed and aggregated states were characterized by the same excitonic peak positions. The magnetic circular dichroism (MCD) measurements conducted at magnetic field strengths of +1.5 T and -1.5 T did not reveal any significant changes of MCD spectra upon the aggregation. The PL kinetics was examined using a time-correlated single photon counting spectrometer Micro-Time100 (PicoQuant). The characteristic PL lifetime was investigated as a function of recording wavelength. We employed 10 nm band-pass filters to selectively detect the emission in a wavelength range corresponding to the PL spectra of QDs. We observed that the QD PL decay time of non-aggregated QDs did not depend on the luminescence wavelength, while the PL lifetime of aggregates increased linearly with increasing the wavelength. Moreover, the slope of observed linear dependance increases, as the degree of QD aggregation becomes higher. We assume that obtained results can be explained by the energy transfer from smaller to larger sized QDs within an aggregate. As the QD colloidal state changes from monodispersed to aggregated, the FRET efficiency value increases up to 40%. alters","PeriodicalId":276715,"journal":{"name":"Proceedings of the 7th World Congress on Recent Advances in Nanotechnology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125858013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double Layer Graphene Oxide Loaded With Propylammonium Nitrate for Selective Adsorption of Inorganic Salts","authors":"H. Abukhalifeh, I. Alnashef, B. Zhuman, I. Zuburtikudis","doi":"10.11159/icnnfc22.147","DOIUrl":"https://doi.org/10.11159/icnnfc22.147","url":null,"abstract":"- Due to freshwater scarcity, desalination process gains more importance. Developing a green and environmentally friendly solution for extraction of the salts from the seawater becomes a major challenge nowadays. Among all desalination processes, membrane desalination is widely used. About 80 % of total desalination plants are based on reverse osmosis (RO) worldwide. However, RO desalination is considered to be costly owing to the short lifetime of the membranes and high replacement costs. Membrane fouling is one of the main causes of this limitation. Membrane inorganic fouling can be easily affected by calcium and magnesium inorganic salts. Hence, it is important to develop an efficient adsorbent used in RO pre-treatment processes to address the problem of inorganic fouling. The great advantages offered by nanomaterials and green solvents allow the creation of new functional materials for inorganic salt adsorption. Ionic liquids (ILs) comprising of an organic cation and an organic or inorganic anion, exhibit superior characteristics and are used widely for different applications, including separation and extraction processes of salts and of several heavy metals in the seawater. However, ILs which have good solubility of inorganic salts are mostly hydrophilic. Therefore, cross-contamination of the pre-treatment water during the extraction process can occur. However, if ILs are supported on carbon nanostructures (CNS), as graphene oxide (GO) or other types of CNS, this can be avoided. As a result, this will reduce the operational costs of the plants by decreasing the amount of inorganic fouling in the membranes. Experimental findings showed that GO modified with IL can successfully adsorb CaCl 2 , MgCl 2 and NaCl salts. Physical functionalization has been confirmed using thermal gravimetric analysis (TGA) and Raman Spectroscopy analysis. Moreover, leaching of IL from GO has been studied using Total Organic Carbon (TOC).","PeriodicalId":276715,"journal":{"name":"Proceedings of the 7th World Congress on Recent Advances in Nanotechnology","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120981153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adhesion, Viability and Differentiation of Adipose Tissue Derived Mesenchymal Stem Cells onto Micro/Nanostructured Polystyrene Substrates","authors":"A. Kanioura, A. Zeniou, P. Petrou, A. Papadopoulou, E. Mavrogonatou, D. Kletsas, A. Tserepi, E. Gogolides, S. Kakabakos","doi":"10.11159/nddte22.135","DOIUrl":"https://doi.org/10.11159/nddte22.135","url":null,"abstract":"- Mesenchymal stem cells exhibit unique properties such as self-renewal and differentiation into different types of cells. To study in vitro these properties, micro/nanostructured surfaces that mimic the morphology of in vivo extracellular environment have been employed as substrates for stem cells culture and differentiation. In this work, micro/nanostrutured polystyrene surfaces fabricated through oxygen plasma etching were used to study the topography effect on adhesion, viability and differentiation of mesenchymal stem cells derived from rat adipose tissue (rMSCs). For this purpose, rMSCs were cultured on micro/nanostructured surfaces with average peak-to-valley height ranging from 50 to 500 nm, for 14 and 21 days, with either standard culture or osteogenic differentiation medium. Regarding cells cultured with standard medium, it was found that both their viability and morphology was negatively affected when cultured to micro/nanostructured surfaces with average peak-to-valley height ≥270 nm, while mineralization, as determined by Alizarin Red S staining, was slightly increased on the micro/nanostrutured surfaces compared to flat ones, indicating that micro/nanotopography did not affect osteogenic differentiation. On the other hand, when rMSCs were cultured with osteogenic differentiation medium on micro/nanostrutured surfaces, their viability and morphology were strongly affected, and a 30% reduction in mineralization compared to flat polystyrene was determined on surfaces with average peak-to-valley structures ranging between 90 and 480 nm. On the contrary, when cells were cultured with osteogenic differentiation medium on surfaces with peak-to-valley structures of 50 nm, mineralization was 1.7 times higher compared to flat surfaces. These results indicate that surface roughness ≥90 nm has a strong negative effect on viability, morphology and mineralization of rMSCs cultured in both media, while surface roughness of 50 nm exhibits a ~70% increase in mineralization of rMSCs compared to flat substrates when cultured in osteogenic medium. Thus, micro/nanotopography could be a useful tool to promote MSCs differentiation in vitro .","PeriodicalId":276715,"journal":{"name":"Proceedings of the 7th World Congress on Recent Advances in Nanotechnology","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128517058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Scale Modelling Of the Formation of the Nanoparticle-Protein Corona","authors":"Ian Rouse, David Power, S. Poggio, Erik G. Brandt, H. Lopez, A. Lyubartsev, V. Lobaskin","doi":"10.11159/icnnfc22.172","DOIUrl":"https://doi.org/10.11159/icnnfc22.172","url":null,"abstract":"Extended Abstract A nanoparticle (NP) immersed in a biological medium does not remain in its native state for long, but instead rapidly acquires a corona of adsorbed proteins. This protein corona masks the original physical and chemical properties of the NP and is known to determine its biological fate, uptake by cells, and potential adverse outcomes [1]. Thus, the prediction of the corona content is crucial for the evaluation of the safety of novel biomaterials to avoid the requirement of experimentally investigating each of the large number of these biomaterials being introduced to the market. A given medium may consist of hundreds of proteins with the corona evolving over the course of several hours. With current computational tools, the simulation of the interaction between a single protein with an NP at an atomistic scale of accuracy is limited to at most a few nanoseconds of time and so clearly an alternate approach is necessary. The vast majority of proteins consist of only the twenty standard amino acids (AAs), suggesting that it should be possible to pre-compute these NP-AA interactions and use these to construct a model for the interaction of the entire protein with the NP, significantly simplifying the task of predicting the affinity of a given protein to the NP in question. Further coarse-graining of the system can then allow for modelling of the long-term adsorption and desorption of proteins, enabling the prediction of the content of the corona. Here,","PeriodicalId":276715,"journal":{"name":"Proceedings of the 7th World Congress on Recent Advances in Nanotechnology","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130566389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hamaker Constants for Bionano Interactions in Water","authors":"K. Kotsis, V. Lobaskin, B. Zhuman, I. Zuburtikudis","doi":"10.11159/icnnfc22.171","DOIUrl":"https://doi.org/10.11159/icnnfc22.171","url":null,"abstract":"Extended Abstract Bionano complex formation and interaction at the bionano interface are important features to understand in detail, so that a firm relationship between the nanomaterials (NMs) of any size, shape and surface charge and their biological activity in water can be established. The bulk of the NM interacts via the long-range van der Waals interaction, which is a major contribution in the calculation of the adsorption energies of biomolecules in water. Therefore, Hamaker constants are advanced descriptors of the bionano interface. We evaluate the bionano interactions through an atomistic Force Field (FF) approach. For metals we use CHARMM FF parameters [1], and for metal oxides and carbon materials as well as amino acids, lipids and sugars the FFs developed and reported [2]. All FF parameters have been applied in molecular dynamics simulations for many properties, including potentials of mean forces. In this work, we present a methodology to estimate Hamaker constants of the bionano interface in water or just the interaction of the NM with itself in water. The long-range dispersion interaction is calculated using the Lorentz-Berthelot rules for 𝜎 and 𝜖 [3], i.e. combining rules that provide the interaction energy between two non-bonded atoms. By summing up all atom-atom interactions to a single parameter, the Hamaker constant between two molecular entities of the same nanoparticle (NP) can be approximated [4] by: 𝐴 11 = 4 𝜋 2 (𝜌 where 𝜌 𝑁𝑃 is the number density of the NP, 𝜖 𝑖𝑗 is related to the induced dipole interactions between two particles,","PeriodicalId":276715,"journal":{"name":"Proceedings of the 7th World Congress on Recent Advances in Nanotechnology","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134447540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sample Preparation Effects on Surface Quality of Specimen Fabricated by Ion Milling Process","authors":"A. Cheesbrough, I. Lieberam, Wenhui Son","doi":"10.11159/icnnfc22.155","DOIUrl":"https://doi.org/10.11159/icnnfc22.155","url":null,"abstract":"","PeriodicalId":276715,"journal":{"name":"Proceedings of the 7th World Congress on Recent Advances in Nanotechnology","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131333218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}