Raman Spectroscopy for the Characterization of Multifunctional Nanoliposomes for Alzheimer's disease and Glioblastoma

Abstract

In recent years, the ongoing growing and ageing world population has led to an increased incidence of neurological disorders. Despite efforts in researching innovative therapies against various brain diseases, the main problem that still exists today is the delivery of drugs to the brain. The blood brain barrier (BBB) has unique anatomical features that mirror its protective role in maintaining the microenvironment within the brain. Thanks to its special anatomical structure, the BBB regulates the exchange of substances between blood and the cerebral parenchyma. This is very important to protect the central nervous system (CNS), but on the other hand it prevents the passage of pharmacological substances that are useful for the treatment of brain disorders. [1] Among disorders, Alzheimer's disease is most form of dementia in the elderly population, while Glioblastoma