Proceedings of the 7th World Congress on Recent Advances in Nanotechnology最新文献

Selective Detection of Natural Gas Odorants Using Microfluidic Gas Sensors with Embedded Micro- and Nanofeatures 利用嵌入微纳米特征的微流控气体传感器选择性检测天然气气味剂

Proceedings of the 7th World Congress on Recent Advances in Nanotechnology Pub Date : 2022-04-01 DOI: 10.11159/icnnfc22.163

Mahan Ghazi, N. Tasnim, M. Hoorfar

{"title":"Selective Detection of Natural Gas Odorants Using Microfluidic Gas Sensors with Embedded Micro- and Nanofeatures","authors":"Mahan Ghazi, N. Tasnim, M. Hoorfar","doi":"10.11159/icnnfc22.163","DOIUrl":"https://doi.org/10.11159/icnnfc22.163","url":null,"abstract":"Natural gas (NG) composition can change based on location and time [1]; however, it mostly consists of methane, ethane, propane, carbon dioxide, and small amounts of hydrogen sulphide [2, 3]. Because of this composition, NG is colourless, and odourless which makes it undetectable in the case of leakage [4]. These properties of NG have caused a few disasters such as the explosion of the New London school in Texas, US [4,5]. After this catastrophe, the odorization of NG became mandatory in Canada [6]. An appropriate NG odorization system requires a continuous monitoring system in addition to the proper injection setup to satisfy the odorization regulations while preventing over odorization. As other sulphur-based odorants such as hydrogen sulphide can also co-exist in the NG, selectivity is one of the main challenges for monitoring NG odorants. Microfluidic gas sensors are compact, fast, low-cost, and easy operated devices that offer selective and sensitive detection capabilities and have been recently applied for the detection of sulphur-based compounds [8,9]. These sensors generally consist of a gas detector and a microchannel [10]. In this study, we achieved improved selectivity for detection of NG odorants (mixture of tert-butyl mercaptan and methyl ethyl sulphide) by introducing micro-and nanofeatures to the microchannel of microfluidic gas In the first are into the and their and are using the Taguchi In the next step, the and are to introduce and increase the to volume ratio. The modified microchannel is by SEM, XPS, and water contact angle measurement. The responses of the modified sensor are recorded and compared to a plain microfluidic gas sensor. The modified sensor shows a selectivity value of 28.59, indicating a 32.54% improvement in the selectivity of the modified sensor towards NG odorants. These results show that the developed microfluidic gas sensor has a promising application for selective monitoring of the NG odorant in the ambient.","PeriodicalId":276715,"journal":{"name":"Proceedings of the 7th World Congress on Recent Advances in Nanotechnology","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121568775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PBPK Modelling for Intratumoral Biodistribution of Magnetic Iron Oxide Nanoparticles 磁性氧化铁纳米颗粒肿瘤内生物分布的PBPK模型

Proceedings of the 7th World Congress on Recent Advances in Nanotechnology Pub Date : 2022-04-01 DOI: 10.11159/nddte22.140

D. Mohamed, A. Howarth, I. Abasolo, M. Montanha, Monserrat Llaguno, P. Southern, Quentin Pankurst, Zamira V. Zamira, N. Liptrott

引用次数: 0

Influence of Diatomaceous Biosilica on the Properties of Composites Based On Dielectric Elastomers 硅藻质生物二氧化硅对介电弹性体复合材料性能的影响

Proceedings of the 7th World Congress on Recent Advances in Nanotechnology Pub Date : 2022-04-01 DOI: 10.11159/icnnfc22.159

W. Brzozowska, Izabela Izabela, M. Sprynskyy, Ewa Olewnik-Kruszkowska, B. Buszewski

引用次数: 0

Surface Plasmon Resonance Imaging For the Characterization of Dual-Targeting-Peptides Liposomes 表面等离子体共振成像表征双靶向肽脂质体

Proceedings of the 7th World Congress on Recent Advances in Nanotechnology Pub Date : 2022-04-01 DOI: 10.11159/nddte22.144

Francesca Rodà, S. Picciolini, A. Gualerzi, Valentina Mangolini, F. Re, Antonio Renda, A. Antoniou, P. Seneci, S. Pellegrino, M. Bedoni

引用次数: 0

On the Importance of Mucin Corona to prevent Nanocapsules Aggregation for Oral Delivery 粘蛋白冠在口服给药中防止纳米胶囊聚集的重要性

Proceedings of the 7th World Congress on Recent Advances in Nanotechnology Pub Date : 2022-04-01 DOI: 10.11159/icnnfc22.175

M. Collado-González, Gurmeet Kaur, Y. González-Espinosa, R. Brooks, Francisco M Goycooleai

{"title":"On the Importance of Mucin Corona to prevent Nanocapsules Aggregation for Oral Delivery","authors":"M. Collado-González, Gurmeet Kaur, Y. González-Espinosa, R. Brooks, Francisco M Goycooleai","doi":"10.11159/icnnfc22.175","DOIUrl":"https://doi.org/10.11159/icnnfc22.175","url":null,"abstract":"Extended Abstract Bacterial biofilms, that are multispecies colonies, provide bacteria with protection against adverse environmental conditions and lead to the appearance of multi-drug resistant strains. Inhibition of virulence by disrupting quorum sensing ( QS ), which is a cell-cell communication strategy, has been recognised for the fight against multidrug resistant bacteria. N,N’ -(Di-m-methylphenyl)urea (DMTU) can be used to fight against oral biofilms, given its QS inhibition capacity that blocks the expression of virulence factors in Streptococcus mutans [1]. NC), 24 lower than ~500 nm. Further increase in mucin content, at mucin: CS-coated DMTU-loaded o/w NC ratio equal to 0.67 w:w, mucin coated completely CS-coated DMTU-loaded o/w NC as seen the highly negative charge recorded immediately after their interaction (< -20 mV). After 24 h, the structures showed an hydrodynamic diameter of ~250 nm, which agrees with previously reported results that relate the decrease in the size with an increase in polymers flexibility Future studies will evaluate the stability of the mucin: CS-coated DMTU-loaded o/w NC in simulated saliva fluid. The results of this work offer new insights into the modification of the surface identity and stability of chitosan-coated nanocapsules which full potential in buccal delivery is yet to be realised.","PeriodicalId":276715,"journal":{"name":"Proceedings of the 7th World Congress on Recent Advances in Nanotechnology","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130809101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development FAP-Targeted Nanotherapy against Cancer-Associated Fibroblasts 针对癌症相关成纤维细胞的fap靶向纳米疗法的开发

Proceedings of the 7th World Congress on Recent Advances in Nanotechnology Pub Date : 2022-04-01 DOI: 10.11159/nddte22.141

A. Bonizzi, M. Truffi, L. Sitia, S. Mazzucchelli, Sara Negri, L. Sorrentino, M. Sevieri, F. Corsi

{"title":"Development FAP-Targeted Nanotherapy against Cancer-Associated Fibroblasts","authors":"A. Bonizzi, M. Truffi, L. Sitia, S. Mazzucchelli, Sara Negri, L. Sorrentino, M. Sevieri, F. Corsi","doi":"10.11159/nddte22.141","DOIUrl":"https://doi.org/10.11159/nddte22.141","url":null,"abstract":"Extended Abstract In the recent years, cancer research has largely focused on biology of cancer-related stroma. The tumor microenvironment (TME) is a highly heterogeneous milieu consisting of different cell types and plays an important biological role in cancer development and progression. In particular, cancer-associated fibroblasts (CAFs) are the major cell population in the TME which support tumor growth, metastasis formation and induce drug resistance, through the production and secretion of variety of growth factors and cytokines, as well as extracellular matrix components [1]. A biological hallmark of CAFs is the selective expression of fibroblast activation protein (FAP), a membrane-bound serine protease of the dipeptidyl peptidase subfamily, not present in healthy tissues [2]. FAP is important for remodeling in FAP-overexpressing cells. Finally, we evaluated biodistribution and tumor targeting of HFn-FAP in a mouse syngeneic model of triple negative breast cancer after intravenous administration. In vivo preliminary results demonstrated that functionalized HFn is able to recognize CAFs and enhance intratumoral retention of the nanoparticles. In conclusion, our findings suggest that FAP-targeted nanotherapy could be a promising strategy against CAFs to modulate the tumor microenviroment and provide new hope to fight the cancer.","PeriodicalId":276715,"journal":{"name":"Proceedings of the 7th World Congress on Recent Advances in Nanotechnology","volume":"211 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116153864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of the Biomolecule Corona in Determining Biocompatibility of Nanoscale Materials 生物分子电晕在确定纳米材料生物相容性中的作用

Proceedings of the 7th World Congress on Recent Advances in Nanotechnology Pub Date : 2022-04-01 DOI: 10.11159/icnnfc22.004

I. Lynch

{"title":"The Role of the Biomolecule Corona in Determining Biocompatibility of Nanoscale Materials","authors":"I. Lynch","doi":"10.11159/icnnfc22.004","DOIUrl":"https://doi.org/10.11159/icnnfc22.004","url":null,"abstract":"It is increasingly recognized that interactions between nanomaterials and available biomolecules lead to acquisition of a corona of biomolecules around the nanomaterials that provides the particles with a biological or environmental “identity” and determines their subsequent uptake, distribution, localization and impacts on living systems. The nature of the acquired corona depends on the available biomolecules and thus will be different depending on the route of exposure (e.g., inhalation versus ingestion) and the organisms under investigation (e.g., mouse, daphnids, plants etc.). To date, there has been considerable focus on proteins, however, another important class of biological chemicals have been largely overlooked in the efforts to understand and predict the interactions of nanomaterials with living organisms, namely metabolites, which are also involved in signaling cascades and toxic responses in biological systems. Methods to explore both protein and metabolite coronas, and the protein-protein and protein-metabolite interactions involved in forming and stabilizing the corona are needed. Emerging research is also exploring the role of corona evolution, and shedding of proteins from the corona following uptake into cells is providing new insights into the indirect toxicity effects that can arise from nanomaterials, which can be viewed as another form of Trojan-horse effect. The role of the corona and its evolution in uptake and transformation of nanoparticles in a range of biological systems will be demonstrated in this talk, including in mediating nanoparticle transcytosis across an in vitro Blood-brain barrier model, in exploring toxicity and repair mechanisms induced in response to nanoparticle exposure in daphnia, and in mediating uptake and impacts of nanomaterials in plants.","PeriodicalId":276715,"journal":{"name":"Proceedings of the 7th World Congress on Recent Advances in Nanotechnology","volume":"2 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131349931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Room-Temperature H2S Gas Sensor Using Flower-Like Zno Nanorods 花状Zno纳米棒室温H2S气体传感器的研制

Proceedings of the 7th World Congress on Recent Advances in Nanotechnology Pub Date : 2022-04-01 DOI: 10.11159/icnnfc22.162

Sara Ghaderahmadi, N. Tasnim, M. Arjmand, M. Hoorfar

引用次数: 0

Fabrication of Nanoporous Hemi-Spherical Micro-Shell Array for 3D Cell Culture 三维细胞培养用纳米多孔半球形微壳阵列的制备

Proceedings of the 7th World Congress on Recent Advances in Nanotechnology Pub Date : 2022-04-01 DOI: 10.11159/icnnfc22.156

Byeong Hee Tae, E. Han, B. Kim, Se Hyong Lee, Y. Seo

{"title":"Fabrication of Nanoporous Hemi-Spherical Micro-Shell Array for 3D Cell Culture","authors":"Byeong Hee Tae, E. Han, B. Kim, Se Hyong Lee, Y. Seo","doi":"10.11159/icnnfc22.156","DOIUrl":"https://doi.org/10.11159/icnnfc22.156","url":null,"abstract":"Extended Abstract Many studies on co-culture with non-parenchymal cells to improve the function expression and activity of cancer cells have been reported.[1] In co-culture, a microwell array for 3D cell culture and a nanoporous membrane for exchange of biomolecules between cells while separating two kinds of cells.[2] Using nanoporous membranes, two types of cells were separated and their effects on the exchange of biomolecules between cells were identified. Previous studies have carried out co-culture with commercial polymer nanoporous membranes, with limitations of low porosity(less than 4%) and high thickness(more than 10 μm ). To overcome this, a thin nanoporous anodic alumina membrane(NAAM) was proposed using high purity aluminum sheet (99.999%) for cell co-culture. When NAAM was used to co-culture NIH3T3 cells and HepG2 cells, albumin was about 1.7 times higher than that of commercial membranes. Through this, it was confirmed that co-culture using NAAM is effective in increasing functional expression and activity of cancer cells.[3] Nanoporous hemi-spherical micro-shell array(NHMA) were made for 3D cell culture in order to apply the advantages of NAAM instead of the microwell array used in previous studies. Aluminum was etched because it had to be hemispherical in order to be","PeriodicalId":276715,"journal":{"name":"Proceedings of the 7th World Congress on Recent Advances in Nanotechnology","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117307484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exotemplate-based Fabrication of 1-dimensional Hybrid Nanostructures for Catalysis and Sensing 基于外模板的一维杂化纳米结构的制备及其催化和传感

Proceedings of the 7th World Congress on Recent Advances in Nanotechnology Pub Date : 2022-04-01 DOI: 10.11159/icnnfc22.173

Khaled M. Amin, Tim Boettcher, M. C. Scheuerlein, W. Ensinger

引用次数: 1